skysight-inc/HackerNews huggingface dataset:
Well UK deaths from flu are about were 500 deaths per 66M for the most recent year of published cause of death statistics, which I understand (from a couple of papers on annual infection rates) represents about 500/13M infections.

Covid19 figures in the UK are 26,000 [hospital] deaths for 165,000 confirmed infections. Even if we assume the entire population is infected ... that makes it a minimum of 10x as deadly as flu. We're at a slowly falling ~5000 deaths per day; when care-home and other Covid deaths get added ...

I think perhaps you're down-playing it a little too much.
You're comparing the IFR of the corona virus with the CFR of the flu
For some, yes. It helps to have a budget for paid ads on IG though.
> What conditions would it need to be a new virus rather than a variation of the original one

The Carl Woese (Woesian?) [0] definition that's been taught for a while is that when a certain sequence within two organisms exhibits a similarity score of < 97%, then it's new species. The certain sequences is generally 16S rRNA. That definition has its problems, but it's even more complicated for viruses: I think it differs for each virus family (e.g., Filovirus [2]). I just messaged a virologist and they said it's too complicated to explain over G-chat.

[0] https://en.wikipedia.org/wiki/Carl_Woese

[1] https://en.wikipedia.org/wiki/16S_ribosomal_RNA

[2] https://www.ncbi.nlm.nih.gov/pubmed/21046175/
Former hedge fund and HFT quant trader here. There's a lot of papers to be found claiming some sort of strategy. I don't want to go to cynicism immediately. But we'll get there:

- Trading isn't just about deciding what to buy and sell, the sexy part that everyone thinks is great. I even had colleagues who thought they were special because they worked closer to the strategies, which meant that certain less glamourous parts were neglected.

- Less glamourous parts like coding the software to read in the market data and send out orders.

- Less glamourous parts like schmoozing with brokers to get them to lower your costs.

- And maintaining infrastructure, which somehow people think should come as part of coding.

Now I'm not saying that RL won't help you. It's just that focusing on the "intelligent" part of the trading system tends to lead to disappointment, as you discover some unknown restrictions on your model that you hadn't thought of. Things like when you find out short selling was prohibited during the period that your model backtest was shorting.

My main red flags when reading papers are:

- Choosing a dataset from a small market. Basically any market that isn't the US or Western Europe large caps. You'll discover both price impact and high fees quite late in the game.

- Choosing a very small subset of the market. Smaller n, more noise and overfitting.

- Short periods. N again.

- Long intervals between decision making. N again again.

That's not to say there's nothing useful to be read though. You might be inspired by something you come across.
I use !gsch for that.
I find this compelling:

> Strikingly, 100% of ICU patients less than 75 years old had VDI [Vitamin D Insufficiency]

Since mid-March I've been trying to keep track of Vitamin D/Sunlight suggestions and papers here: https://simonsarris.com/sunlight
Human body-on-chip platform could speed up drug testing
The reference does include the meaning as applied in this thread, you just have to read past the first couple sentences. You do understand that the same word can have different meanings depending on the context, right?

Edit: because I think you just won't be able to get there on your own, look under the heading "Defined benefit plans" on the Wikipedia page for Pension. If you need help defining the words in that section let me know, my spoon is ready to feed Chris Seaton, the Shopify Senior Staff Engineer that doesn't understand context.
Raspberry Pi Cluster Ep 1 – Intro to Clustering
I believe Lyft generally has a slightly wealthier clientele: more middle-class people choosing not to drive. Uber has more reach in the lower ends of the market. So when the stay-at-home orders flooded in, these middle-class people all stayed at home, while Uber was still serving essential workers.
SPAs are a lot of work to get right, if you want to stay within JS, node/express/postgres and Pug/html/css(with some sprinkled JS) would be faster and simpler IMO. You can still use Firebase's auth feature from the server.
Immunity will presumably last at least a few months, and the problem always reaches its greatest severity in the winter months because people are indoors more. We will just default to the influenza model, where there are circulating betacoronaviruses every season and we try to predict and vaccinate against them. The Middle East deals on and off with MERS.
Everyone's an armchair virologist all of a sudden in this crisis. Heartening to find we had such expertise just lying around, waiting!
>Less gets done means the country gets worse and people get more radicalized trying to improve things.

This opinion requires a great deal of justification.
Open Source Spatial Analysis Tools for Python: A Quick Guide
We put together a list of free spatial analysis tools for Python. Please let us know your comments and/or ideas.
Small arms and asymmetrical tactics have quite substantive results in places like Afghanistan, Yemen, and Iraq. Let's not write off potential danger because of lopsided resourcing.
You could ask the same question about many government contractors. I would dispute calling what they've done "nothing," though. Building a facility of that size and complexity is obviously a non-trivial task, especially when they're having to solve multiple large-scale problems that have never been solved before.
Sounds like it (I've also heard of zinc being added in with HCQ and the z-pak as part of that treatment protocol, sometimes called the "Raoult protocol" and referred to hereafter as such for brevity).

Both the Raoult protocol and remdesivir appear to help if used earlier in the disease progression; neither seem to do anything if the disease has progressed past a certain point.

If early use is the key to efficacy (and if both demonstrate the same degree of efficacy, as it seems currently), the Raoult protocol is the only one that makes sense to scale up. The ingredients for the Raoult protocol are much more easily mass-produced and administered, whereas remdesivir is proprietary, very expensive, and IV-only (as other posters have noted).
Their high GDP per capita is not going to fix their insolvent pensions or runaway spending. Illinois has a BBB credit rating (just above junk!). Are you really just going to ignore that because of high GDP?
https://en.wikipedia.org/wiki/List_of_U.S._states_by_credit_...
Phones are multi purpose. You do a lot with it and having every piece of information crammed into layers of applications is not the best design.

Some pieces of information, specially those regarding productivity like calendar or a kanban board are better delegated to solutions designed just for that. A whiteboard, a dedicated LCD screen, an eink dashboard controlled by a raspberry pi... Take your pick, as long as it is always visible.
Ok, overwhelming market leader then.

The rules for it should be carefully considered, since it is a unicorn.
I've heard plenty of comments like that. People often trivialize things they don't understand. As a developer I tend to focus on that one feature I know how to build and ignore the rest.

Or in other words - it's easy to bake a bread loaf but running a bakery is much more complicated.
I've been using Firebase in production since 2016 and I would not recommend it.

Once you learn how it works, Firebase will get you from 0 to 10 really fast but will slow you down as you struggle to go from 10 to 100. By then your app/product will have so much Firebase specific code that you will need to rewrite a significant portion of code to move out of it. Let me know if you want me to expand with specifics on why Firebase is bad.

If you need something easy to start fast I'd say go with Hasura. It will give you one-click GraphQL API over Postgres. Your front end will simply use standard GraphQL so you can change your backend without touching the front end. And Postgres is still Postgres. Even if you decide to completely rewrite your product you could keep using the same database.
I love Airbnb, but don't have a lot of sympathy for the property owners and speculators in this situation.

There is nothing wrong with owning a rental property, but the answer to loss of income is simple - sell the property and cash out while ahead.
> we will continue to see pandemics until unsanitary practices like wet markets with exotic animal products are outlawed

I'm really no expert and don't know what to think, but Wikipedia asserts that as of April 2020 investigations are still trying to determine whether the Huanan market was really the source of COVID19. Even if it was, can we even conclude getting rid of these markets would solve pandemics as a general problem?

So at this point we can't really say the "fix" is to remove these markets, can we?
Mostly congressmen, not senators. And that's what earmarks are.
The parent suggested a degree of change along a spectrum, you list possible consequences that might occur only if one takes the most extreme form.
Make the Game Easy
Since, things are slow, my notes....

Misc:

- Fremont plant idle since March 23rd

- raised 2.3B in February, which seems really well timed now

- Musk venting with "FREE AMERICA NOW" tweet makes him seem almost crazy

- can see why Elon is going crazy on twitter, he'd almost turned around Telsa and now they may be in the worst cash crunch of their long life

- Shanghai Giga reopened on Feb 10th, showing the importance of multiple factories around the world( around 150,000 in capacity once they get going for Model 3, Model Y not yet and should be incremental on top of Model 3 number)

- Berlin Giga scheduled to start producing Model Y's in 2021, so capex drain for rest of year and probably into 2021

- TSLA trying to run an amazon HQ2 like process for Truck and Model Y factories, look for small, southern, and poor cities to bid and probably win

Numbers:

- 1Q Revenue $5.99B vs Estimate $5.81B

- 1Q Free Cash Flow ($895M) vs Estimate ($604.4M)

- GAAP net income of $16M for 1Q

- sale of ZEV in 1Q $354 million vs $133 million from Q4, not going to have this to bail out their quater in 2Q

- 35 Megawatts of solar( down by about a third Q/Q)

- sitting on $8.1B of cash, sweet!! but burn rate is approx ($3-4B) a year

After:

- semi not until 2021

- not reaffirming numbers, will check in again in 2Q, makes sense

Want to know:

- Solar roof? give up or start committing, hard to sell to consumer during shutdown

- battery storage for energy, growth area or sign of lack of focus and minor distraction to core business?

inventory growth? Building cars no one is buying or still not able to keep up with growth or finally found balance between the two?

- Will Elon stop with tweets that hurt Tesla? Appoint a CEO, or COO to run things to take pressure of Elon?
A certain set of people take enormous pride in using unstyled HTML like this. (See "Motherfucking Website" [0])

The problem is it's not 1994 anymore, monitors are no longer 800 pixels wide, so it looks like shit and is impossible to read. It's well accepted that 70-90ish characters per line is best for readability, and instead now on an average monitor unstyled HTML gives you like 250.

[0] https://motherfuckingwebsite.com/
I didn't think "do without" was a legal option anymore.
Kylin is a really cool project, and how it's using OLAP for faster analytics on large datasets/big data is interesting - especially given how old the technology is. The Kylin community has found some creative ways of breathing new life into OLAP. If you'd like to join the project you can learn more here: http://kylin.apache.org/
I don't think we have any reliable evidence of post-recovery immunity at all. I wouldn't expect to have any until we've seen multiple cycles of this virus, and analyzed the data carefully. Press-release-science during an emergency is close to worthless.
Ooh, sweet false dichotomy!
If you're concerned, this belongs in an email to hn@ycombinator.com, not on the thread itself; the guidelines ask specifically for us not to have discussions like this in threads.
This was a mistake on our website, which as since been removed.

1. We'll be open sourcing our client in the coming weeks so you can check out our code yourselves.

2. We will be offering a self-hosted version which will decouple you entirely from our infrastructure and you can provide you own SSL certificates.

3. Lynk can forward traffic to your encrypted services - which of course would mean losing out on compression benefits, but Lynk is designed primarily for quick development work like testing out a Stripe or Github webhook on your local machine, or demoing your webapp to a remote client. For production use we recommend a reverse proxy or self-hosting Lynk.
Off-topic: after years of struggling with obsolete Python versions (like author here with 3.5) I have recently discovered pyenv. Never again will I be left without f-strings! Kudos and thank you to authors.
Supporting the the continued lockdown is not only unamerican and illegal but it is also RACIST.

All the H1-Bs in California are going to be screwed within another month. Hope you like being racists you liberals!
I knew someone would come in with "liquidity".

Many HFT jump out when things get volatile, when liquidity is actually required.

Ultimately HFT is doing nothing of societal value, the race down to zero is never-ending and we are wasting huge amounts of resources on a totally pointless march towards zero. Exchanges should introduce random delays to allow market participants who really want to hedge / buy / sell, then we can shift some of the resources to the real world. The costs required to compete at the lowest latencies are large, and forcing small/medium players out the game, as the investment cost is large, which is also bad.

The system is hugely inefficient. The costs as latencies get lower are ever higher, for an extremely similar end result. The law of diminishing returns.
I ran a curl test and noticed that the TCP connect time is where things are getting hung up, taking over 80 seconds! Does anyone know if this is indicative of deliberate rate limiting or just a bad peering connection?
Something feels almost PR spin about this. “No, look, see, billionaires Are doing good!” I can’t help be feel suspect about this website.
DDG is not in the index-all-the-web business. For the most part they are just serving Bing's results, that's the only reason why they operate with so little funding - it doesn't take much to operate a glorified proxy. Microsoft's footing the bills for the actual web search operation and I'm sure it's way above 13M.
Paper from Plant Waste Can Replace Plastics: Varden Startup Receives $2M Boost
My thoughts are that amidst the fear, the thing is, this economy was slowed solely due to the lockdown. If there was a bubble, it hasn't popped yet. There really is no reason for the economy being in the position its in except for the virus. I doubt there will be 3rd order effects that are too devastating. The lockdown will end soon enough and the economy will thaw and start moving again, maybe even to the roaring pace it was at before all this happened ... and after all that is when we will likely see the actual once-a-decade market-correction/recession/depression.
Sigh. I was waiting for the "Govts have overreacted" message. This is a ridiculous criticism to have to the response to this pandemic. We NEED to overreact so we don't underreact.
The "User in DnD?" box made me chuckle.
This is, unfortunately, standard practice for the ASF. After Google shut down Wave in late 2010, they donated the code to the ASF; the project [1] sat largely inactive in the Apache Incubator until finally being shut down in 2018.

If you poke around in Apache's project list [2], you'll easily find other projects which followed a similar trajectory -- a few months, maybe a year of activity, followed by years of neglect.

[1]: http://incubator.apache.org/projects/wave.html

[2]: https://www.apache.org/index.html#projects-list
Because the demoscene culture doesn't mix with FOSS one.

Back in the day we wanted to have the cool demos at the parties to show off how we managed to do something that others deemed impossible.

Part of the challenge is to match what others did and out win them, without having access to how they achieved it in first place.

Older Macs were never a thing in Europe given how expensive their were, Comodore, Atari and Sinclair machines ruled Europe.

While UNIX and demos never were a thing, those were more the domain of cracking competitions. Trying to gain access to some random university server.
i think it’s just because they want to publish, and as you say it’s not easy to find a really good publicly available dataset or simulator. I think if these were publicly available and there were a Python package, people would rapidly get interested in RL for trading. (if it even works for trading — i don’t know much about it but maybe simpler techniques work best, in which case there would be little chance of producing a publishable paper.)
Higia Fever Detection
As I know well as a KA-10 MACLISP programmer!

But most people these days have a hard time realizing what it was like to program a machine with only a few K of memory. PL/1 (the Multics implementation language) had bounded strings. C did not as it was believed the PDP-7 couldn't afford it. Of course by today's standards the GE 645 is an absurdly tiny machine.
A lot of the reports you're citing are just press-release-science being turned into breathless headlines.
"No. As the person you're responding to pointed out: "The viruses that cause colds, many of which are also coronaviruses, are pretty adept at hitting people throughout their life.""

Yes. I'm talking about the question of immunity, not whether or not it's possible to get re-infected by new strains of the same virus, or whether or not immunity fades over time. It would be unlikely that this virus didn't confer at least short-term immunity to the host.

The viruses that cause colds primarily re-infect because they mutate at a very high rate. We aren't seeing that with this particular virus.
No, but he'd let New Mexico fail (it's blue) and ram through a bailout for the rest out of political patronage, and the legislature would go along with it, since the Democrats seem to be allergic to actually opposing Trump policies.
Hi!

I've written an analysis of Lynk's performance vs. Ngrok here: https://medium.com/@shivanshvij/building-a-better-ngrok-dbc1... and our documentation stating "SHA-256 Encryption" has been since removed as a mistake.

The client side will absolutely be open sourced probably by the end of next week once I've cleaned up some spaghetti code.
Someone just pointed out to me that some source code was recovered from an old tape using a baking method. Interesting!

https://strandgames.com/blog/magnetic-scrolls-games-source-c...
Just curious -- if a country didn't want a site to be seen, why would they rate-limit it instead of just blocking connections completely?

Is that a thing countries do, like if they want to "punish" a site while retaining plausible deniability?
Presumably immunity goes away once the antibodies are gone, but does the body remember the virus for next time? Assuming the virus does not mutate too much from year to year, at what point will it not be novel anymore to the human body? Will subsequent infections be easier for the body to fight?
Zero-sum in wealth, but not zero-sum in utility. Otherwise, people wouldn't trade at all.
I wholeheartedly agree, to a point. Sometimes hideously complex things look so easy because really smart people came up with a particularly elegant solution, so any rando off the street sees it and figures they could reproduce the thing.

However, I worked for a company who had a whole team of engineers and QA people working for months on what was basically a Django CMS, but with a large dose of "not invented here"-driven writing of everything from scratch. I'd finally gotten tired of it, so I spent a weekend at home implementing it in Django and being done with it.

I did learn two very important lessons, though:

- The other stakeholders really did not like someone demonstrating a working prototype of something they'd been doing unsuccessfully for months, and I got a thorough chewing out for disrupting their processes.

- I really didn't want to work for such an organization, and was much happier after moving to a smaller, more nimble company.
If it does indeed turn out to be useless (which is far from obvious at the moment), it'll be dropped, and not much money will have been spent.

It's unfortunate, but a lot of what we're trying right now will turn out to be useless. One or two recent analyses suggest that the (far more expensive) lockdowns might turn out to have been almost useless. That doesn't mean that trying them was the wrong thing to do.

We're living in unusually uncertain times.
Juul is reportedly laying off 800 to 950 employees
Technology Innovation Open Call via Technologycatalogue.com
Good analysis but as the author knows: M D 5.

> While MD5 hashing is no longer a good choice when considering a hash function, it is still being used in a great variety of applications

Such as? I wouldn’t want to know who is still using this algorithm unless you need to maintain compatibility with old software perhaps.
The way people use OOP causes them to move the complexity in a particular way. That's why the distinction doesn't make a difference in this context. You're right, technically it wasn't OOP that was writing the code, it was the person. We would have never figured that out without your guidance, we all just though OOP was banging away on the keyboard.
Looks cool, anyone got any good use cases for it?
> Following an old gradient and only updating when it becomes clearly obsolete

This sounds exactly like a linesearch https://en.m.wikipedia.org/wiki/Line_search
One of the currently popular mutants of the virus has a mutation in the proof-reading exonuclease that causes the virus to mutate much more often than the original strain.

https://translational-medicine.biomedcentral.com/articles/10...
> The viruses that cause colds, many of which are also coronaviruses, are pretty adept at hitting people throughout their life.

Yes, but you're almost always immune for at least a year. By then, we should be getting close to a vaccine.

And when you do get one of those viruses again, it's significantly less severe the second time.
Yes, it was and this has since been removed.
Does make me wonder how much of this is VDI and how much of this is the general population having VDI.
Better than hardcoding some fixed or percentage width, leaving 5 inches of wasted blank space on the left and right side of the page, like many web sites do.
I never have this problem because it always takes me solid weeks to properly design and implement a single new feature in my photo editor's user interface. Sure, I could slap something shitty together in a weekend, but then you have a shitty UI and people complain about open-source software UI enough already.
> The Cello approach would require me to modify the interface to accommodate the new size header that is packed with the array. ABI break, not compatible with existing C code and libraries.

Isn't the entire point of the article that this is not the case?

My understanding is that a Cello array is laid out like this:

<metadata header>.<actual payload data in standard C format>
^
|
this pointer is what you pass to existing C code

The existing C code gets a pointer to data exactly as it expects. It does not get a pointer to the metadata. It could access it by subtracting an offset from the pointer it's given, but it will not do that since it does not expect anything meaningful to be there. "This pointer is fully compatible with normal pointers".