skysight-inc/HackerNews huggingface dataset:
Only one thing is clear about our immune system: it's extremely complex and even after a century of prodding it, we still don't know it well enough to prod it in targeted ways and know what to expect.

Especially, suppressing the immune system is always dicey, since its not just one variable you tune up or down. However, there _is_ a magic bullet of sorts out there, Intravenous immunoglobulin (IVIG).

IVIG is just concentrated antibodies made from plasma of thousands of donors. Its original use case was to clear out a patients antobodies to suppress any antibody-mediated autoimmune response, but turns out IVIG can have global immunosuppressive effects through other mechanisms as well. Importantly, it's very "benign" - almost no known side effects, and your general immunity is still left intact. This has led to extensive use of this drug off-label for anything dealing with excessive immune responses.

The more and more I think and look, the more I'm convinced IVIG might help worsening covid patients. Indeed, a case study from China suggests it can be beneficial (3 of 3 very sick patients fully recovered) but of course a proper study is needed (IVIG is quite possibly the worst drug to try and ramp up production). On the other side, a pre-covid trial of IVIG on ARDS patients (already on EMCO) showed no effect, though I personally felt the study was too broad. More studies are also needed, because I'm sure any _new_ IVIG made, since it pools thousands of patients' plasma, is bound to have anti-covid antibodies as well, and this could have some potentially dangerous effects as well (Antibody-Dependent Enhancement). But I'm still cautiously optimistic and am hoping to write to some experts after gathering more data to see what they think.
duplicate, please check before submitting: https://news.ycombinator.com/item?id=22895784
Future of World is in the hands of better APIs and not better Products
Energy consumption is a function of how many people live and need energy. Sure we now have to fight to provide sustainable energy for 8 billion and soon 11 billion people.

At two or three billion it would not be an issue at all.
It also seems relevant that he is Iranian as he has notably decided not to play under the Iranian flag. Reading the article, multiple paragraphs are spent discussing this aspect of the story.
What is Bitcoin, and How does Bitcoin work?
2). If you include civil war and if you allow that civil war to be a war of factions within the CCP then you're wrong. There will be a new leader of the CCP, call him / her China's Gorbachev (and SARS2 is China's Chernobyl) and this will eventually lead, with assistance, to the de-Communization of China within at most 15 years but possibly just two.

update: possibly 6 months.
A good immune system is kind-of luck-of-the-draw; that aside, I’m exercising daily.
And an adjective. I'm shocked.
It's a virus that is completely unadapted to the human body, fresh off the boat from whatever animal it evolved on. It's like an early prototype medication: it already has the desired effect (reproduction in a body part that serves as a launch pad for transmission to other hosts), but it's chock-full off side effects. Unfortunately, it is so good at pre-symptomatic transmission that those side effects impose very little selection pressure.

At this point we have an interesting link to the topic of contact tracing apps: if we shift our countermeasures from wholesale isolation to fast, computerized contact tracing that is fast enough to overtake the infectivity/symptom last, it will increase the evolutionary advantage of less damaging strains (asymptomatic cases don't trigger a contacts cascade)
You haven’t missed anything and your skills are still relevant if you want to solve problems.

Laravel or Python with server-side rendered pages is still perfectly valid and will be better than the majority of websites today. People who say otherwise have their career at stake because they know nothing but React and need to use it everywhere (regardless of whether it’s necessary) to ensure their survival.

You don’t need Docker either. It helps in some cases but also adds an extra layer of abstraction and moving parts so I’d avoid it when possible. If your app just relies on a database and maybe a cache server it’s easy enough to install those locally without Docker.
These doctors have specialties. Fighting coronavirus wasn’t one of them
It gets really repetitive and boring to see this sort of comment (and often much nastier ad homenim attacks) every single time any of pg's writing is on the front page.

If you think his observations are mundane, then why not just move on to another link, hopefully one that you're interested in?
which part didn't you say exactly?
Yeah, that really is not enough for me to visualize what they meant.
>that's a biosafety level 3 or 4 facility
As dramatic as that sounds, you can get commercial and home aircons that will filter at the level to kill or remove viruses.

Though for COVID-19 you would want something that can filter at 0.125 micron as that is the size of this virus.
I thought the "remove two regulations to add one regulation" was an interesting hack.

Don't know if it's political rhetoric or even viable.
I'm from Denmark, but emigrated at an early age to the U.S, I always hated butter until I came back to Denmark, so if you had asked me 20 years ago I would have said hell no, but now I have managed to taste some really good butters and maybe it is worth that much, just like a good cheese would be.
https://github.com/pastpages/savepagenow

Please be mindful about request rate and content size, we don’t want to abuse the Archive.
The body you intend to complain about is not "the" NHS, but the government Department for Health and Social Care.

> The UK is now at the bottom of the world leaderboard for testing, because its 100% centralised and government run healthcare system has totally failed at scaling up capacity.

The NHS had capacity. The DH&SC decided that testing wasn't worthwhile. (I disagree with them, but they were saying that covid-19 is so contagious and testing doesn't affect the treatment someone gets so there's no point testing them, and when they made that decision we didn't have reliable antibody testing).

> One reason - it's actually refused and ignored testing capacity in the private sector.

That's not a decision for "the NHS" to make.

Testing the population for Covid-19 would be Public Health England, not the NHS. PHE has a central arm, but is mostly split out to local authorities.

But PHE can't make that decision if the minister has said not to test.

> because its 100% centralised and government run healthcare system

That's not at all how the NHS works in England. It's mostly not centralised. Most commissioning is done locally by Clinical Commissioning Groups. They buy services from NHS providers who, again, are mostly local organisations. There's some central commissioning, but that tends to be very specialised services. ("inpatient mental health treatment for deaf adults", for example.)
Hm, at $job we're already sending all git commits to a Bugzilla (no bug in commit comment => push is rejected). Parsing the comment or diff for these instructions shouldn't be too difficult.

Though we have several products + subproducts defined in Bugzilla (that's why we can't easily migrate to more modern solutions). Not sure if there is this can be easily mapped automagically.

Also, keeping track if the comment is moved around, especially if slightly altered with the same commit, might be less straight-forward. Also merges might be a pain.

Could also be done for those chancy subtask/checkboxes gitlab and github offer (and which I really miss in bugzilla).
I read speculation based on protein protein docking, that it could limit ability of hemoglobin to bind oxygen. On the other hand it can't enter red blood cells so it does not make sense.

But I think you would see high blood oxygenation even in a person with CO poisoning as it just measures whether something is bound to hemoglobin
I keep noodling my way around this

https://github.com/mikadosoftware/todoinator/blob/master/tod...

The idea is a sort of markdown approach to things todo in the code

[ ] Must foob the blah
[x] Rewrite for snoobs

It kind of works - I get a view of a codebase as it was when I last left it. It is rather like trying to serialise my brain state as Instop coding somIncannpick it up again.
You're quite right. Garbage in, garbage out. And if the cost of generating garbage goes down, we're going to get a lot more of it! There are definite risks in misinterpretation and complexity and cruft. As Genesereth quoted:

The Lord's Prayer is 66 words, the Gettysburg Address is 286 words, there are 1,322 words in the Declaration of Independence, but government regulations on the sale of cabbage total 26,911 words.

So, we will have be on our guard. The hope is that if the rules are open and machine-readable, we will be able to counter with software that sides with the user and helps to mount the sort of response that in the past was only available to corporations with very deep pockets.

One intriguing approach is to submit test cases: concrete scenarios, or traces of events, that should result in certain desired outcomes. A diverse range of people in different circumstances could be collected in a comprehensive test suite. If the contract/law passes the test suite, you're good! You can imagine two legislators from different parties with different constituents and concerns, each bringing their set of test cases; and when the negotiated compromise passes enough tests, they proceed, without ever actually reading the text of the bill, lol.
Depending on your viewpoint, this may actually be a boon for reverse engineering efforts to counter planned obsolescence.
I had never heard of an ACE score, it is interesting. I’m a 6 and my wife is a 9. We grew up poor too. We had a kid at 15 (heh, hi ACE score in action). She was an A and B student and I was nearly all A’s. I don’t know if the IQ test I took back then was legit, but I was 150 or 140. I don’t want to get too deep in the woods, but I want to say you are not your numbers. You have it in you to be happy, to be successful, and to have good relationships. My wife and I are still together since 14 years old. Three kids, a good home, I love my career and job, I have hobbies I enjoy. It is not all sunshine and rainbows and life has been HARD. The stats say we should have ended up one way, yet we ended up another. You are not your numbers.
I can’t really promise the “before”, but the e-book will be released when the current round of review and edits is complete. The physical books released when I can figure out the logistics of printing and distribution
The Post-Pandemic Style
Only ones who need to keep firmwares secret will be affected.

There are few companies I knew who transitioned from MCUs to FPGAs solely for their obsession of keeping their "IP" from leaking, hoping that FPGA will provide more obscuration than simple encrypted MCU firmware.
I’d rather he cram this letter up his arse and lead by example with a letter announcing deep investment in infra

Otherwise this is just someone with the freedom to sit around rambling at length trying to look woke

The model of investing he got rich on is part of the problem

Is he actually going to change that or peddle warm fuzzies and never follow up?

Academia knows where the problems are

States know where the problems are

Pay taxes and they can get on it right away

What is it with rich guys who think they’ve suddenly figured out exactly what societies already well known problems are?

What is it with sycophantic men who kowtow to rich daddy types? The professional world I live in is pretty disgusting with its reverence for wealth stolen from workers who do the actual manual labor to enable his creature comforted up the arse life
You'd be surprised. In law enforcement we'd get served with the craziest stuff from criminal targets that were attorneys. They'd literally try to bluff us into believing that whatever statute, evidence, or investigative methods relevant to the case were futile and would end up costing the agency millions in damages awards. In a case like the one in this article, if you can bluff a jury, you're golden. You could literally shoot someone in the public square and get away with it if you convince the jury it was reasonable.
Interesting read. My father-in-law died of Covid-19 last week. The thing that got him in the end after a 9 day battle was kidney failure. He had heart problems and diabetes already as underlying conditions.

There’s one thing I take away from all of this and that is to eat and live healthy to reduce the things working against you as you get older. Age is bad enough on its own.
Even if there was a more prominently stated, formal policy about when downvotes are appropriate, it would make no material difference; the overwhelming majority of downvote-inclined people will downvote any comment that gives them a negative feeling.

That said, some of the best comments are ones that carry an argument that most people would disagree with, but are worded persuasively and/or informatively enough that they attract upvotes. It's difficult to achieve but well worth aiming for.

Outside of encouraging that, I'm not sure what else dang is meant to do. Discussion platforms that try to enforce policies like requiring explanations for any downvotes don't seem to have substantially better quality discussions.
Who would gain? Politicians try really hard to pull in facilities. Look at the GLobalFoundries spending debacle in NY. Or the Panasonic/Tesla battery facility in NV at, what 2m in grants per employee. Or Foxxcon in WI.

These facilities aren't that economically beneficial. Capital investors aren't, as PMA implies, stupid: they don't build because there isn't much money in it.

Politicians bend over backwards all the time. Massive subsidies are the problem, not lack of interest.

The reason people go elsewhere is to play regulatory arbitrage. To avoid the inspections, the pollution rules, and the long term environmental costs. The Bay area is filled with Superfund sites. Same for the Puget Sound, Boston Harbor, and the Hudson. No one should eat too many fish...because worlrdwide Mercury levels are high.
From the paper:

> On these devices, the bitstream encryption provides authenticity by using an SHA-256 based HMAC and also provides
confidentiality by using CBC-AES-256 for encryption

> We identified two roots leading to the attacks. First, the decrypted bitstream data are interpreted by the configuration
logic before the HMAC validates them. Second, the HMAC
key is stored inside the encrypted bitstream
So can I use this hack to use open source tools on these FPGAs?
Or use the Windows SDK and the COM type library browser.
Watch the SICP video series:
https://www.youtube.com/watch?v=-J_xL4IGhJA&list=PLE18841CAB...
In this thread we have at least one person saying deaths are over-counted, and there are plenty of similar comments on HN.

I agree about the down voting.
This is unnecessarily snarky. Nobody is claiming to reinvent anything, just someone sharing their wisdom.
If the FPGA can be updated, attacker can take over the hardware and reprogram it.

If attacker gets access to the bitstream, the has complete control over the FPGA.
It's clearly labelled as an opinion piece.
I read a report on a GBS patient who recovered after getting immunoglobin

Edit:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4...
From the non-gatekeepers' perspective, the difficulty of policy implementation does not matter when the policies themselves are ineffective and only serve to maintain status quo financial structures, which benefit the wealthy often at the expense of the most vulnerable.

What specifically makes the president unpresidential as opposed to other presidents? Is it removals as a percentage of the estimated illegal immigrant population? The dramatic expansion of the power of the executive branch into the realm of national security? Number of U.S. citizens executed without trial? Those are all things which happened under previous presidencies.

> If the Republicans had done their job as well like usual

Is it really fair to argue that gatekeepers are effective if they failed to do what you view as their jobs? "If it wasn't for those meddling Republicans!"
Couldn't there be a million other things that change light absorption?
Self-sovereign identity is probably the most viable use case at the moment. No third party needed to manage your identity, replace keys, and broadcast updates to the world. Additionally adding the dimension of time, where you can differentiate between something signed while a key was active vs something signed after the key was retired.

Some argue this is the only data necessary on-chain — all other application data can remain in normal data stores while the identities interacting with that data are immutable and auditable.

Laying the groundwork for a lot of neat stuff
https://identity.foundation/working-groups/identifiers-names...
At this point in the essay, Andreessen is wondering aloud why more building hasn't happened in the United States to solve problems in fields like education, manufacturing, and transportation.

He asks what the reasons could be, and lists several rejecting each of them. One reason that he rejects for why more building hasn't happened is capitalism.

Andreessen thinks capitalism can't be the reason for us not building because the fields he mentions are places where it's profitable ("highly lucrative") for businesses to operate. Replacing capitalism with another system (say communism) wouldn't solve our inability to build, in Andreessen's view.
> this is of course because their offspring, the present working-age demographic, are busier than ever at work.

Even if I was retired, I wouldn't want to spend several hours of my day nursing someone. I'm not good at that, and I don't enjoy it.

> people would live in multigenerational homes

I would much sooner live in a small apartment with my wife than have either of my parents in my house. They aren't my friends, I don't enjoy their company, I would be constantly avoiding topics that my wife and I talk about freely like politics or sexuality.

One of my parents doesn't know that I'm transgender and the other one isn't thrilled about it. I would expect a lot of negativity about that.

> I’ve always felt they were essentially warehousing elderly people so that their families didn’t have to look after them.

Maybe they're a local maximum.

We've realized that taking care of seniors, especially when they live longer than ever in gradually worsening health, doesn't sound like a good use of our time.

But euthanizing them is obviously off the table. [1] So the nursing home evolved as a way to 'politely' live as though your parents or grandparents have already died.

Nobody really likes it, but the alternatives are worse.

[1] It might have been acceptable in a small farming village in the old days where the alternative was everyone starving.

But it's hard to justify when the only thing I might lose from a multigenerational lifestyle is my own happiness, my free time, my freedom, a lot of money, and my marriage. If I only stand to lose everything _but_ my life, it sounds selfish to say I want them to live somewhere else.
I chose not to get married and have kids. I like being alone. I dont want anything to do with kids. As far as I'm concerned you picked your bargain, i picked mine. I do not expect any sympathy when i die alone either.
Maybe. But there also seems to be a tendency not to admit that any exponential phenomenon in the real world (Moore's Law, economic growth, etc) is always the climbing part of an s-curve. Call it wishful thinking, or optimism, or self-delusion, according to your preferences :)
Opt-outs highlight the tension between privacy and revenue at Twitter
Isn't the original use of IGIV as a supportive therapy for people not producing antibodies (for whichever reason)?

In the case of COVID-19, plasma therapy (which transfers antibodies from a survivor to an infected) is one of the more promising short term mitigations.
Sure, just mailed it to you.
> If he did what he is proposing, he would be out of business quickly with no investor money to mess around. This entire post reads like a script for Gavin Belson to me.

But this is sort of the central complaint, no? "These people have to want it" is a good rallying cry, but it should apply to Marc and his peers and funders. They have enormously more influence on the direction of industry and infrastructure in our countries than I do, and it'd take a revolution to change that dynamic.
Only because Common Lisp has been around so long that people have forgotten what Lisp was like before it. Old school Lisp hackers like Rodney Brooks were not fond of the dialect, which they felt was bloated (see Brooks and Gabriel, "A Critique of Common Lisp", 1984).
I reject the presumptions that the only possible response is a unitary authority and that we shouldn't do anything in response because any such response is automatically going to be bad. Come, on, this is Hacker News!

Why do we have to have a single central authority? We ought to at least be willing to speculate about AI-mediated Blockchains of Truth that reward factually accurate reporting. Or about ways to smoothly tell users how accurate the source they're reading has been in the past, or how to implement smart filtering of information streams to protect our own minds so that we can avoid wasting time on cognitive hazards.

The point is that we have options beyond just sitting back and giving up. The problem is real, as are the risks to responding poorly. But that doesn't justify not responding at all.
success in one sphere subconsciously molds people to believing their opinion matters in other spheres - even if they are completely disjoint?
Can you provide some examples. I have no idea where I would get lectured on morality in my adult life.
I'm starting to think that this kind of idea is dangerous.

Chinese apps are left unchecked as long as they are loyal to the regime, but international companies would be held accountable back home for their actions in China, in an inevitable race to the bottom, this is competitive disadvantage and outsiders are doomed to fail.
>This limits you to .38ACP

FWIW, I don't think PPKs have ever been chambered for .38ACP; most PPKs these days are chambered in .380 Auto, though there are older variants chambered for .32ACP, a modern variant chambered for .22LR, and a few other oddball variants that use other cartridges.
No good DB UI on Linux?

You never heard of DataGrip then?
Pardon my ignorance about compilers, Haskell, and programming in general (I have no background in CS, please don't roast me :), but cannot the Glasgow Haskell Compiler (GHC) produce a (binary executable) package that could run in Linux/Windows without having Haskell?
The ticket serves as a communication point and a cost estimate tool. Even if the tasks are never explicitly assigned they are very useful. That's why I'd like a comment ticket linkage system. Support the positives of both usages by automating everything.
It's pretty cool. I probably won't use it, because it's rather "heavy," and I don't really need it, but I like.

I suspect that we'll be seeing a lot more of these kinds of things, coming out of this "house arrest" situation.
But they'll suffer from environmental pollution and disasters, not to mention a neofascist society - so the joke's on them ...
This is a much better version of what I was going to respond with, which was, "I dunno, Marc, you're the one with all the goddamn money, you fix it." I think we're on the same page.
Reduce the number of characters keeping the text understandable