skysight-inc/HackerNews huggingface dataset:
I understand the staff and equipment part, but the plans & researchers were there already in the Chinese study that was cancelled because of lack of patients in China (BTW I haven't seen any news about the cancellation of the trial, which is very sad news).

In this research it looks to me like Gilead doesn't really want to show how (in)efficient remdesivir is in reality.

From 2400 participants there would have been enough for a control arm.
I'm not sure though which would be weirder:

That this very widely used drug is actually effective against coronaviruses and we never noticed before.

OR

That this drug isn't effective against other coronaviruses but just this one specifically.

Ivermectin is a worm treatment. A variety of human diseases (and some non-human diseases) that involve parasitic worms can be treated with this relatively cheaply (but not Guinea Worm interestingly). It's basically poison for the worms but mammals mostly seem to tolerate it very well. Because it's so cheap it's a go to option even in cases where maybe another drug would be better if money was no object.

So it'd be weird if we never noticed it cures the common cold for example. When its given out as a mass intervention in places that have endemic worm infection, the population report the expected upsides like they feel healthier or they have better sex (likely placebo effect) plus some things connected to worms (it cures other worm infections they had, because the drug doesn't care which worms you were targeting) but we don't get people saying "Oh my cough cleared up" or "That's weird, now I don't have a fever" in data I've looked at.

Now if it doesn't work on other viruses from this family but it does work on this one that's one hell of a coincidence.

Maybe I'm missing something, it could be that over in some corner of the world they've found that this drug has some very particular effect that exactly matches what you'd want from something to treat COVID-19, but otherwise this is a pretty crazy thing to find.
Criminals and scammers sure like that though.
Chiming in to say ThisOldTony is alright.

https://www.youtube.com/user/featony

Stefan Gotteswinter: https://www.youtube.com/user/syyl

Keith Rucker: https://www.youtube.com/user/ksruckerowwm

Richard King: https://www.youtube.com/results?search_query=Richard+King
You should support ACME.
Did you miss the quote literally starting this (sub)thread?

Senior Defense Department officials were barred from answering questions on the subject during interviews
> Incidentally, this is the real reason manholes were round.

This doesn't pass the sniff test to me. A manhole lid fits loosely in its frame, and is simply cast. The round shape is used ecause that way the lid cannot fall into the hole (frame is a slightly narrower diameter than the lid is in any orientation)
Michigan Protesters, You Know Nothing of “Nazi Germany”
You would remove the 50% charge limit prior to undocking so that it's at 100% right on time. Calendar integration could easily automate the limit-removal time (maybe 30min before you have to leave, or whatever is needed).
>And, unless you are someone like Edward Snowden with huge secrets to reveal, probably no one will be willing to expend the effort to hold an encrypted email conversation with you.

Not to mention even Glenn Greenwald did not expend the effort to learn GnuPG, even when Snowden sent him a 10 minute tutorial.
> Almost everything starts with a "gotta do something".

Not in regulated industries in 2020. Anything that resembles a medical device will need approval, and gobs of cash.

So far I don't think DIY ventilators or containers make any sense (ie. meet FDA approval), but homemade face masks seem ok.
OK, slow down. What FDA actually said was "do not use ivermectin intended for animals on humans": https://www.fda.gov/animal-veterinary/product-safety-informa...

Physicians can and do use drugs off-label at their discretion all the time; the FDA is not charged with regulating that. (They do, however, regulate the advertising of a drug with claims which are unsupported by clinical trials.)
It's a nice idea, but I think the final statement is overly-optimistic.

The U.S. has bungled its response to this (ongoing) crisis much harder than China did, and I think our economy is going to suffer more. For all the corruption, China's bureaucracy displayed a reasonable level of competence in tackling the issue once they actually got rolling.

The U.S. response continues to be a complete circus of organizational failures, lack of leadership, careless misinformation by our own chief executive, and a free-for-all of independent state action (and inaction).
I worked for a company (startup) that built a very unique engine. It was SQL on top of anything - literally.

It fell into the domain of "data federation" or "data virtualization" - something that is quite overlooked by the new generation of tools such as GraphQL - but they are starting to realize that federation/virtualization of data is exactly what these tools provide. One need look no further than Apollo GraphQL to find language showing they are starting to understand it better.

Anyway, Calcite is great for building a SQL engine (parser, lexer, planner, optimizer) because it's a framework independent of any backend system and storage engine.

That said, other people have taken the approach of using any open source SQL database, including Postgres, Apache Derby, SQLite - and basically tearing out the SQL engine, wire protocols, JDBC drivers, and removing the storage engine piece and making that pluggable.

As some others in the post have mentioned, SQL/MED is a feature built in to a number of databases, but if you really wanted just the SQL engine without the rest of the DBMS, the approach above is the one I have seen - deconstruct the database into just the SQL engine and just use that.

These days you can also try to use things like Apache Spark as a programming framework to build such an abstraction as well (with dataframes and SQL over those).
That sentence seems purpose-build to be so obviously trying to hide the truth as to be giving it away.

It means the "DoD personnel who evaluated proposals" were not pressured by senior DoD leaders, but by White House officials directly.

Or why would the statement explicitly mention "DoD leaders more senior to them"? If they were not pressured, why not simply say "DoD personnel were not pressured to award..."? And why would they be barred from testifying?
I wish he could have cured RadioShack. It was nice to have a local store for electronic components.
Yep.

1) It's against human nature - in aggregate - to prefer working in solitude at home. WFH may increase, but remote won't anywhere be the "mainstream"

2) No, the position of China in world economy will ironically grow. Getting supply chain out of China will introduce unwanted inflation into developed nations in EU and US - that's not what these countries need after printing many trillions of dollars.
Striking Protest Photo Wins World Press Photo of the Year
There is a key area where mail is central: The "I lost my password" feature of websites. Apple ID, Google+ (or whatever they call it now) and Facebook login replace it to some degree (especially on mobile device apps) but for far most websites newly created passwords or activation links are sent via regular mail unprotected.
Surely that's purely subjective. I look at a lisp and gasp, but that's because I've never really used it and am not used to it.
I don't use humor in scientific presentations
Many laptop manufacturers seem to be doing this already. For ASUS laptops, there is a Windows store app that lets you control the setting:

https://www.microsoft.com/store/apps/9NKCLN5X4RR9
"Before we can close you up, what is your name, address and phone number for the form?"
It would be great if they made this available for Mojave... Catalina seems like such a shit-show that I have yet to upgrade.

God knows my laptop is spending alot of time on its charger at the moment.

Given 10.15.5 is likely to be the last version of Catalina before whatever comes next... maybe it will be time to jump in?
> Practically Signal offers little advantage over any messenger with transport encryption (e.g. Facebook Messenger): in both cases you pretty much have to trust the organisation itself.

There's a critical difference you're papering over: the level of trust that is required is very different. With transport encryption you have to trust that the infrastructure is secured on an ongoing basis. With end-to-end encryption implemented in a real-world app (i.e. distributed through a walled garden) you need only trust that the version of the app delivered to you is based on the code it claims to be.

> Signal does do a few good things that PGP-based cryptosystems don't. But the downsides massively outweigh the upsides in my book.

One of the things Signal does well that PGP systems don't is actually being usable by real humans, which for a security system is everything.
Please be careful with anointing winners, that stops people from exploring and evaluating all the options, and encourages force feeding whatever is “in” into their projects.
Is GitHub really free for teams? Should you go for it?
"alternative schooling methods (e.g. AI remote teaching, virtual classroom environments)"

My bullshit indicator went far into the red...

Let my try:
"alternative schooling methods (e.g. AI remote teaching, blockchain enabled holistic virtual classroom environments)"
They are only strong at specific points, namely the corners and to a lesser extent, the edges. If you have a load on top, or an impact on the sides, they deform easily and that can cause structural collapse.

In situations where people bury the containers, they often have to weld in additional squarestock steel pillars and ceiling joists to improve the structural integrity of the roof, and the pillars often add needed support to the walls that face substantial forces from the weight of the earth
Why “Ketchup”?
The core thermal management of macOS seems to be better than Windows:

https://youtu.be/LGOmbNRlZdM?t=495 (8:15)

And I've always gotten better battery life on average on MacBooks than other laptops, and in macOS than in Windows on the same Mac.

The problem is when there are bugs (of which there are many) in the other higher-level daemons and third-party apps that get stuck in some task and cause the CPU to unnecessarily shoot up.

For example I try to do things like renice +20 for every Steam process, because it's a bad macOS citizen and suddenly shoots up to 100% CPU for no reason, but it doesn't help until I terminate them. Even the TextInput etc. daemons get randomly wonky and have to be terminated.
What is your basis for claiming that the typical incubation period stated by the WHO is wrong?

https://www.who.int/news-room/q-a-detail/q-a-coronaviruses
Hi Patrick.

I am the person who asked the question that Nick responded to.

I understand PayPal has stronger network effects that may give it more leeway in handling the banks that a smaller competitor may not have.

I do agree with Nick that Radar should be a free service for all users. It reduces headaches for everyone involved. Why charge for it?

(Post to my above post if you reach HN's post limit.)
I don't think so. This is the nature of software.

The first version jumped right in and solved an immediate problem. Even with the best foresight possible the designers simply could not see all the problems they would run into.

Or even if they did, sometimes pragmatism forced fixing issues down the road.

After doing this for over 20 years (I build software coders/designers/laymen use) I am really impressed with how well Vue was designed to start with, and the migration path (at a glance) looks nearly painless from v2 to v3.
I'm calling it now, I bet many people (>20%) have had it, whether they realize it or not.

To be honest, I think it was all over the Bay Area in late December, Early January (when I'm pretty sure I had it) and Feb.
Doesn't help on the intranet that easily, when the application runs on a domain not on public DNS. Also ACME can be problematic from policy POV.
I'm pretty sure Tom Nook is one of the most powerful and merciless authorities on the planet.
Ask HN: Do you avoid PHP jobs when job searching?
I find myself doing so unless I really like the rest of the job and/or company enough to offset the PHP requirement. I don't totally hate PHP, but I just don't enjoy developing with it. And there still seems to be a stigma associated with it that it can't shake despite much progression and improvements.

Is this PHP job aversion irrational? Just curious if anyone else here would also skip over a job posting if it involved PHP development.
It's important to remember that there are still a lot of front-end folks who aren't interested in application engineering, but still might find these frameworks useful. For those kinds of people, static typing is a harder sell.

For anyone else, yeah, they should probably be using TypeScript in 2020.
There is a De-motivational Poster from back in the day with a picture of a skier doing an airborne yard sale. Captioned with 'If you can't learn to do something well, learn to enjoy doing it poorly'

A diamond right there.
During this recession, CTOs should look at saving money on Cloud
You're welcome to not use it.

The whole reason this exists is because "these grocery store features" don't exist.

Sites should be implementing their own waiting list, but that hasn't happened, so here we are.
Probably not. The numbers I’ve seen suggest that far less than 5% (I think it was 2%) of websites use a library like react, Vue, or angular. Of course, you can use Typescript on its own, but if you are using Typescript, chances are you are also using one of the big 3.
Such access is FAR LESS secure for most real humans' threat models.
The humble phone call has made a comeback
Giant viruses aren’t alive. So why have they stolen genes essential for life?
FaceID is dead until a coronavirus vaccine is developed.
I doubt you're really at 100%... if you go to "Apple menu > About This Mac > System Report > Power > Battery Information" you can look at "Health Information > Cycle Count" and see how many cycles you've been through... see "Cycle Count Limits" at https://support.apple.com/en-us/HT201585 for expected lifetime. You could also look at "Charge information > Full Charge Capacity (mAh)" and compare that to whatever the original capacity was for that model.
ACA requires insurers to refund premiums if they do not spend at least 80% of the premiums on healthcare. See here for more details:

https://www.cms.gov/CCIIO/Resources/Files/Downloads/mlr-repo...
Hopefully nobody actually throws phones out. That bundle of molecules does not belong in a landfill.

My library has a dropbox to refurbish old ones for blind people, for example, but I'm sure dozens of places will be happy to take them off your hands.
I guess that would point to generational territoriality driven by pop growth, i.e, each new generation has to expand into new territory with occasional infill when the initial settler generation fades out.
> you give a correct and complete answer

The article asserts no answer; that they were forbidden to answer those questions. Written or otherwise.
It's now up 13%, and was up by 16% when NBC reported.

https://www.cnbc.com/2020/04/16/gilead-stock-surges-after-re...
I've written difficult and complex SQL, over a 20+ year period, along with taking a deep dive into relational theory via Chris Date. I'd say I fully grok SQL; well I'm still learning as are the majority of us who are not Chris Date. It's a vast and comolex topic, enough that there are experts specific to it for an entire career. Graphql is great because it's far simpler. I learned how to use it on the front-end in a matter of hours. And learned how to implement it on the backend in a few weeks. It's a different level of abstraction, and shields our front-end devs from many underlying complexities, including but not just the SQL.
Running at 95C all the time is not "better".
TL;DR: not much.
How to Use Random Seeds Effectively
I´m interested in benchmarks, but could not find any. During the development they promised some serious optimizations.
FWIW you do not need to 'sign up' on IRC, just pick up an unused nickname and you're in. No registration or anything necessary.
really, the issue is no one wants to admit they were wrong.
Aren't an absurd number of websites made with WordPress still?
OK that's good to know. Is their government handling it any differently than other countries? Or has it in the past?
> A central premise of the federal procurement system is that “full and fair competition“ on a “level playing field“ means that competitors are asked to make their best bids without knowing what the other has bid or will bid. That principle ensures that companies seeking to do business with the federal government offer their best price from the beginning.

No, it doesn't. This is known as a first-price sealed bid auction. It guarantees they will roughly speaking offer the government the highest price they think they will win at, not their lowest price. For a more detailed analysis see the wikipedia aritcle: https://en.wikipedia.org/wiki/First-price_sealed-bid_auction

The "standard" (mathematical) answer to getting this property would be to run a second-price sealed bid auction, where the winner is the player with the lowest bid, but they get paid the amount of the second lowest bid, https://en.wikipedia.org/wiki/Vickrey_auction

I'm not sure how you would best adjust this system for non-identical goods.
Same, I had it starting January 4th in the SF (North) Bay Area, I'm about 90% sure.

I was probably basically a super spreader too, tbh. I went to work every day, 'cause I tend to power through whatever is thrown at me. At least I avoided shaking hands.

People were even talking about it back then... they didn't know it was Corona, but friends I know who are nurses were saying there is a "weird, bad respiratory infection" going around, and a lot of "atypical pneumonia" and a "really bad flu season but it's a weird flu".

We already had it weeks and weeks before the shelter-in-place in the Bay Area, I'm very sure.
> then winning that bid by offering a better product at a lower price, and faster,

Did you actually deliver on time and on budget?
Yeah... he's right.

I'll refrain from elaborating but we're dangerously close to seeing guillotines being assembled again and have been for quite awhile now. It'd be a lot easier on everyone if we moved wealth downward and worried less about about ROIs on Big Money investments for a bit.
The cells that generate the antibodies may die later.
I adopted typescript shortly after it’s release and went through growing pains in the first couple years. I don’t use it often now. And it ALWAYS comes back to bite me in the butt when doing any decent sized project. If I had to guess time spent fixing things that would have been caught out weights the cons of using typescript
Release too many feature updates on Mojave and they'll just risk customers saying that Mojave is a shit-show.

When 100 million users use the product, every patch breaks something for somebody.
> But death numbers and hospitalization numbers don't lie.

Well... there is some indication hospital staff are being directed to assume all cases are COVID19 until proven different. Patients that die with presumptive COVID19 are reported as COVID19 deaths.

So agree, numbers don’t lie. But... handling emergencies effectively can lead to problematic numbers.
It was the contention to which you were responding, in a conversation which was similarly challenging the WHO (and everyone else's) estimate on the severity. And I was pointing out that you can't do that, logically your argument was a tautology. The same effect you were arguing against would argue against your evidence.
I'm using Go with Redis for various aggressive caching needs. I batter Redis and Go performs very well. A few other languages will work mostly fine for my purposes, however I like working in Go and have always had a great experience with its performance.

No traditional testing. Standard library and Redigo. That's it.

No pain points for what I'm using it for. I usually try to avoid complexity in anything I build. This is a rather simple system that is only meant to take a high volume beating, cache to Redis (content later retrieved & presented by another part of the application via another language) and be reliable.
And that's not to mention compliance enforcement required on the government's side, which I imagine isn't so easily scaled up at a moment's notice.
I think the original plan was to eventually phase out the Options API, but the community pushed back during the first RFC phase resulting in the dual API solution.

Although the benefits of the Composition API are clear-cut, the Options API is beloved by the community for its ease of use and clarity. For me personally, it will be hard to switch since I'm not a heavy user of mixins and I don't venture too far beyond simple components. However, I still need to learn the Composition API in more detail so I can make a more informed decision. Evan and the Vue team worked very hard on v3 and I trust them to make the right decisions.
Forgive me, but I’m having trouble parsing this. Are you saying you recommend using Typescript, or not?

If yes, why do you not use it often now?
It's popular.

26%, 33%, or 36% are some estimates.

1. https://managewp.com/blog/statistics-about-wordpress-usage

2. https://trends.builtwith.com/cms/WordPress

3. https://w3techs.com/technologies/details/cm-wordpress
The tooling for Typescript still isn't good enough to claim that accolade. There are still combinations of libraries, linters, editors, and frameworks, that throw opaque errors that will roadblock students and junior developers significantly. Ultimately until browsers can accept Typescript directly without a compilation step it will remain a second-class citizen. Until then, all of Webpack, gulp, parcelJS, problems and inefficiencies are Typescript's problems and inefficiencies.

It's not fair - Microsoft and co. have done a tremendous job with the implementation and documentation of Typescript. But the reality exists nonetheless.
My working theory is that the Venn diagram of organizations self-hosting software on an intranet with private DNS and organizations that don't have an internal CA is almost entirely disjoint.

Are the policy concerns you raise related to the above, or something else?
I really wish that they make the transition from 2.0 as seamless as possible.
Of course. It’s one patient with no control.

Still, that seems like a quick recovery drug or not.
even those who aren't..
Well, it's pretty clear in this case. Typescript has even more traction and better integration (like VSCode's magical definition fetching) than I think anyone could have imagined. It dominated its reasonable competitor, Flow.

It's kind of a freak win. I think we can say confidently that nothing is going to usurp it.

Not like any compile-to-JS language has come close even when JS was at its worse. Now JS is so good I don't even know why I'd use another dynamically typed language.

We rarely get blindsided by what actually gets traction because almost nothing does. Something that looks like Typescript isn't going to beat Typescript. Something that's more foreign looking certainly isn't either.
Any important grid data and control signals go on a hardware VPN network run by, I think, at&t. There's no way to get on that network unless you're authorized.

This is for caiso utilities, other regions might have less or more security.
AMA with the citizen-scientist who shared America's first Covid-19 serum survey
Thanks for sharing the story. I am curios if you applied both for MD and OD schools? Anecdotally, I heard opinion, that OD is more tolerant to people, who choose medical field as a second career or older applicants.