skysight-inc/HackerNews huggingface dataset:
The researchers gave whopping doses of chloroquine to both groups:

(a) high dose chloroquine (600 mg chloroquine twice daily for 10 days or total dose 12g);

(b) low dose chloroquine (450 mg for 5 days, twice daily only on the first day, or total dose 2.7 g)

In addition, all patients received ceftriaxone and azithromycin.

So group (a) got 1200 mg chloroquine the first day and group (b) got 900 mg chloroquine the first day. No wonder they had irregular heart rates! Luckily a review board stopped group (a) treatment before they killed all the patients.

In contrast, the regimen for Covid-19 successfully used by Dr. Zev Zelenko on ~700 patients is:

1. Hydroxychloroquine 200mg twice a day for 5 days,

2. Azithromycin 500 mg once a day for 5 days,

3. Zinc sulfate 220 mg once a day for 5 days.

https://www.freerepublic.com/focus/f-news/3829492/posts

The zinc sulfate is _important_ because it raises the blood level of zinc (Zn++ ion). Chloroquine is a zinc Zn++ "ionophore" which marshals Zn++ across the cell's outer wall into the cytoplasm where the Zn++ can halt viral replication.

"Chloroquine Is a Zinc Ionophore":

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/

(PDF) https://journals.plos.org/plosone/article/file?id=10.1371/jo...

Some researchers seem to be missing the point that chloroquine and its analogs may play a different role here than in malaria, acting not directly against covid-19 but as a facilitator for Zn++, which then halts covid-19 replication.

Zelenko's use of an antibiotic(azithromycin = Z-Pak) is a prophylaxis against potential secondary bacterial infection; the antibiotic would not likely play a role against the viral infection directly.

Once again we see that randomized, double-blinded clinical trials can be more deadly and less informative than ad-hoc studies performed on the battlefield of medicine.
Have they been told they have to close? In the UK half the population is under the errant belief that unless you are a nurse you shouldn’t be working.
If they could hire someone full-time to do it, they would, I think. I say this because every single company I've consulted for has tried to pressure me into coming on full-time. I always politely decline, but it is exhausting sometimes. I remind myself that I'm fortunate and that I should be grateful for the opportunities.

Either they can't hire fast enough, or they can't have the employees deliver fast enough.

Anyway, I don't know if there's a clear pattern.

Let me just list a few examples:

1. Large company. New CTO wanted a proof-of-concept. Big company with slow teams and processes. He got me to build it fast, and demoed it to the board, and got the leadership team excited.

2. Startup. CTO and the 3 engineers were mobile devs. They were raising their next round and wanted a web version of their product. Ended up building a full product that got them much bigger traction than they expected.

3. Startup. CEO and the investors thought that the team needed to focus on X. CTO thought that Y will actually get them product-market-fit. CTO asked me to build Y, and the CEO agreed, to preserve optionality. Turns out the CTO was right.
> There comes a point when so much is broken or in need of changes, especially when most of it’s essentially in one area (in this case, the win32 GTK theme it’s using) that that traditional wisdom (which I normally follow) ceases to be true.

I think it's even more true for cognitive behavioural reasons. A volunteer-driven project in particularly works best with small, easily digestible problems that can be individually doled out to (or accepted by) people with limited time. It's beneficial because it shows progress to participants and issue submitters.
Sad to see this is dependent on an extension to WebRTC that’s (currently) Chrome / Chromium-only. It’s still a proposed API, and I don’t see when this will be supported by any other browsers.
I think the GP suggested modifying the game design as seen by the players, not trying to implement the same games by doing (impossibly?) clever things under the hood.
College advice for people who are like me
"If that means fewer flights available and higher prices in the future, that's a net positive for the planet as people will have to be more selective about travel."

I've lurked near daily on HN for over five years - and this is the unfortunate comment I finally feel the need to make an account to reply to.

I presume you're living in the U.S. based on your comment.

I too live in the U.S., with severely debilitating health issues. I've been chronically ill for over half of my life now, and only just recently could I legally consume alcohol.

I'm in the MidWest, and have to somewhat regularly fly to California and Massachusetts for medical treatment. I have no parents, and haven't throughout the duration of my illness. I receive no government assistance financially, because our medical system is shit on recognition of many musculoskeletal illnesses. My insurance is also shit in general, because medical care availability is shit in the U.S.

Anyways, I'm practically only alive/still somewhat sentient because of availability of cheaper airline tickets to get to my care.

Don't advocate for making accessibility even more expensive unless you're going to also make sure that people like me (which there's a surprising fuckload of) don't have to rely on it.

Check your privilege, or something like that. Or maybe I should, and just let my body die ^__^
> Scaling back civilization is not the solution. Technological progress and smart regulations are.

Scaling back tech is definitely a solution. Especially a modern spin on "older" tech (e.g. bullet trains, passive solar heating). You speak so matter-of-factly yet there's no evidence that more "progress" is the solution, when there is no way to be sure (its a gamble), whereas its a fact that scaling back our reliance on more tech is a known solution.
Thx ... I've added it to the title.

Pretty much a timeless war story, though.
I've actually been buying food through Amazon (canned goods, protein bars, nuts, etc). Normally, I order online from a local grocery store, but the local grocery store, every time I go to the website, tells me that there are no available delivery slots in the next two weeks.
> intellectually disingenuous...

Given poor testing/tracking, it probably was floating around in the USA 3 months ago. I am not saying that COVID-19 is not deadlier, but that food-borne illnesses are serious and rife in the food supply, and can lead to death for compromised individuals, yet we have not shutdown our markets or meat processing facilities despite outbreaks of food-borne illnesses being somewhat common. Those illnesses can indeed lead to death for thousands of people each year, especially those with pre-existing health conditions.

Also the cruise industry is notorious for food-borne outbreaks of Norovirus. These cruises typically have multiple incidents every year, and are great vectors for spreading viral infections, yet the cruise industry has never been shutdown.

You think eating bats and going to church are not comparable, because that's your opinion on what's culturally normal. Others might say eating a bat is delicious and going to church is dumb. Both have risks and I am not a fan either. No one should be eating bats or going to church right now, but that's going to offend people on both sides.
If only we could have financial markets. I mean real ones, without massive money printing and similar manipulation by central banks.
Large drive on one machine in my house, every computer in my house backs up to there using Restic. I keep hourlies for 2 days, weeklies for 2 months, monthlies for a year, and one extra year.

I also back up to Backblaze B2 using Restic and do the same thing except no hourlies.
Double checked to be sure that "KILL ALL HUMANS" is not among them
Maybe it's just the way I look at the world, but I find it ~beautiful in a way when instances of the very phenomenon discussed in an article can be found within discussions on the article.
Citation(s) needed.
Where I live, all delivery and pickup slots are booked and none of the stores are willing to commit to a date and time.
I have avoided to install Everything after I have witnessed the chaos that results from its use in everyone's folder structure. People use to leave files everywhere without any organization criteria and simply rely to use Everything to find everything.
I still remember my first program!
Hello world!
I'm comparing it to JavaScript, which you can simply run in the browser or in NodeJS without requiring anything else but your code. You can't just use TypeScript, you have to compile it to JavaScript before, as the runtime is still either the browser or NodeJS.
One of the bigger issues with COVID testing is false negatives. I wonder how an even smaller sample of viral load will fare with that.
Machine Learning Template that saved me hours of head-scratching
Banking software developer here. Cobol is specialized and mainly for maintenance. In banks. Has been mainly phased out, if it can be.

It is an investment in a dead/dying language. Why is that worth your time and effort? Have you tried Cobol programming? Do you like it? I dropped out of my Cobol class in college. Was mind-numbingly boring and archaic to work with.

Are you trying to find a viable alternative to JavaScript? That pays 6 figures? You could pivot your javascript skills into something like react-native... mobile app development.
No, I said no such thing. If you happen to be in a dynamic environment, then yes, I see no foul in describing inputs to a function inside a comment above function declaration. Use comments to describe your intents on non trivial parts of your code. There is no amount of code readability that will help your colleague, if she doesn't understand your thought process at the time of writing the code.
How does this hedge fund (or even the existance of such a fund) provide such signals to an inventor or business founder?
Instead of throwing, you just abort the program. If you are running part of a backend service this is reasonable, under some assumptions.

If you fail to allocate memory, there’s a good chance that your process can’t continue servicing requests anyway. So, it’s a good tradeoff to abort. The client can retry later or with a different backend, and the job scheduler can start another instance of the process.
Scratch has been great for my 10 year old daughter. She was off last week for spring break and started learning it on Saturday. By the following weekend she had written 4 or 5 games and was so proud of her first platformer game.

It teaches some solid programming concepts and the ability to easily "remix" (aka fork) someone else's code is a great feature.

The only downside is that now she's obsessed with how many likes she is getting on her games once she publishes them.
Track The Corona virus stats from your terminal using CURL
I should have been more explicit, but by other platforms, I meant ESEA/Faceit that provide their own anti cheat systems that run independently of VAC. I'm not sure I'm really seeing many people go to ps4/xbox simply because of some cheaters on PC?
A Comic Strip Tour of the Wild World of Pandemic Modeling
I have been following the progress of this project on Twitter for months. However I'm very skeptical to see this project used in a production app.

Re-implementing the entire JS toolchain for a modern SPA is a HUGE task, just checkout CRA dependencies : https://github.com/facebook/create-react-app/blob/master/pac...
You're fixated on it being about you specifically and your devices and direct benefits. If your phone's WiFi detects an SSID at a location and 10 other devices confirm your findings, then when I come along and connect to that SSID, with my non GPS enabled Tablet,my experience can be enriched with coarse location contextualized information. The same is true of IP addresses.

> SSID even though I have it "hidden?"

A hidden SSID is only hidden when it's not being used. That is to say if you setup your AP to not broadcast it's SSID then it's only invisible so long as you have no clients connected to it. As soon as a client connects to your "hidden" AP then it's SSID is broadcast to everyone and their mother.
Philosophical question: if humans are gone, does it really matter what happens to the earth?
It does, however, reward content creators for their efforts (at about 100x the value of an ad view). That makes it far superior to NewPipe and ytdl, to me.
Mainly iCloud sync, tabs, and larger previews where more than one is visible at a time
> most do not likely return the item for a broken resealable package

I am and I encourage everyone else to do the same. I bought a package of matcha tea from Costco that has this problem and the quality of matcha degrades quickly when exposed to air.
But do you have a way to migrate to new hardware when the time comes?
And really, a VAT might be slightly regressive in practice because poor people tend to spend a larger fraction of their income but it's still pretty close to being a flat tax. If you were to try to fund a UBI with a head tax that would indeed be pointless. As long as rich people tend to spend large amount of money, in absolute terms, than poor people a VAT+UBI combo is going to be progressive.
Zwift breaks participation record for virtual cycling event
Various folks working on C++ tooling at Google and e.g. Abseil have commented in talks—no, the standard library is not required to support exceptions. They are in fact disabled. Code which would throw an exception instead aborts the program.
Where "next day" can mean 4 days later if you initiate the transfer on a Friday afternoon.
You do know that the bear population hasn't quadrupled in the park since the covid-19 shutdown, right? Bears don't have a gestation period of a month.
It doesn't for me, and hasn't. Perhaps this is a browser or addon behavior?
Extension authors were asked to update their extensions to the new API, so that is one of the breaking changes.

I've updated my simple extension¹ for applying matrix transformations to create drawings in an isometric perspective accordingly. The 1.0 beta's of Inkscape gave quite adequate feedback to help transition my Python code, so it was quite straightforward to do.

1: https://github.com/jdhoek/inkscape-isometric-projection
Happy ending to my YouTube video on where all the code came from in The Terminator. I tracked down the author of one piece and emailed him out of the blue.

https://www.youtube.com/watch?v=YRnnjoiSV-U

Here's the code: https://gist.github.com/jgrahamc/9a90399f39926857b19e8635b30...
Ask HN: Indoor Gardening – What to Grow?
I live in a small NYC apartment with plenty of natural light. What are some things I can grow indoors (food-wise)?
Excellent. Thanks for the link. They are in Beta so I can't evaluate yet. If they're doing what I think they're doing, that's exactly what I'm looking for. However, if the original newspapers only allow Blendle access to a subset of their material, this won't cut it. I need to be able to go directly from a HN link to any NYT article, or at least access the same article through my Blendle subscription.

Time magazine failed in this respect with Roku. I got all excited until I saw what dreck Time was restricting us to.
Politicians right now are in, "it doesn't matter if we do the right thing, it matters that we look like we're taking authoritative action" mode. This happened after 9/11 too.

Right now, 0.1% of the US has had Covid-19. For heard immunity we need that number to be at least 500 times larger.

So, what's the plan here? Wait for a miracle that isn't coming? Stay in quarantine for a year and risk societal ruin?
> What about the massive increase in views from people being stuck at home ? wouldn't that lead to a higher ROI when people eventually spend ?

That would lead to lower ROI as operating costs are increased to serve those extra users. Sure, with more users they'll serve more ads, but as total spend by advertisers is shrinking those ads will go off at bargain prices, it's simple math.
Sure, they're leaders in different disciplines which seem to overlap in the zeitgeist. I doubt Zizek would be able to match Peterson when discussing practical psychiatry.

IMHO, after a brief fascination I've found my enthusiasm for Zizek fading. He seems to know his quotes very well and spits them out like a rapper on speed, but as a career philosopher and author I haven't seen his work leading to positive change in people. Peterson on the other hand has a growing cohort of I regret to say 'followers' who are purportedly cleaning up their acts.

IMHO the group (and subsequently the ideology) is the wrong level of analysis to diagnose and then treat our contemporary woes. Groups cannot be addressed simultainously, cannot be held accountable, and most of all are never clearly delineated (what is 'race'?). The individual CAN be held accountable, that's how every law system on Earth is engineered. The individual can be addressed. That's how almost every communication system in the world works (except public PAs, radio, and the like). And most of all individuals are trivial to delineate. An individual human is unlike anything else in the universe except other humans and each has their own unique history.
Show HN: Lozya – Spatialized Jitsi Meet
How that could work with suspend/hibernation when one doesn't do reboot for weeks?

I rarely shutdown Linux desktop. I also keep desktop VMs with project context suspended to just reopen it next day or in a month to be at place where I stopped the work.
Not sure I agree with this thesis. I think after this, people will see Amazon in a new light. More like a railroad (of days past) or electric/cable company. A utility. People have very few places to turn to during this crisis, and Amazon happens to be there.
Reuters is restating the "April 13" update at Amazon's press blog post here (which is updated each day without changing the URL):

https://blog.aboutamazon.com/company-news/amazons-actions-to...
I just set up Tessaract for screenshot OCR purposes following below post and gotta say it's super easy and great. https://apple.stackexchange.com/a/354036
In this scenario, Walmart has both an "Amazon" (warehouse+delivery) part and a local grocery store part. The warehouse+delivery part should stay.
Show HN: I made a free mobile game to raise money for Corona relief, feedbackpls
I'm not suggesting not trying. I'm just saying this won't be the final nail in the coffin for cheating.
Does it work with Deno? I'd love to burn down the existing JS world and move to a better one.
> This does NOT close out of "hard" blockers that require payment to view content because that is illegal.

This implies that "soft" blockers like this aren't illegal, which is a topic of debate and to my knowledge hasn't been legally tested.

I dislike paywalls as much as anyone else, but I wouldn't assume that paywall bypasses are kosher. It's not analogous with ad blocking.
The golden recipe: neovim, tmux, rg, fzf, i3/other tiling wm on nixos/arch

Fzf all you can, not just inside vim, but also use it to switch between tmux sessions in an instant. I have a tmux manager on top of tmuxp that is able to start / switch to already started sessions via fzf.

Identify patterns you use a lot and make snippets out of them. Create project templates.

Have a folder where you dump reference / things that need to be really easy to find, and set up vim to search into that instantly, no matter where you are.

Keep an inbox file to throw things in, make a wm bind a script to prompt for text and append it there via zenity. Don't throw links into it, it's gonna be a bookmark dump.

Make sure your todo system is a keybind away at all times.

Review your way of working, challenge, and improve it. Be lazy, but only when you afford it.
Video Archive from MIT Media Lab
Removing? Hardly. I'm just saying that as a feature, it's not on the critical path to mass-adoption without solving the key-tracking UX.
I would be outright shocked if Google is unable correlate video viewing habits via direct downloads to a Google account. Especially since they (google, facebook, et.al) have already demonstrated the ability to strongly correlate IP traffic with an account (active or shadow).
This is a lie: no you don't need to use old hardware. I use a Thinkpad X1 Carbon (5th gen) and everything sans-fingerprint-reader works perfectly with FreeBSD 12.1, entirely built from source and ports. The trackpad even works buttery smooth, with inertial scrolling using the Synaptics X driver.
"Make Food Delivery Service Sucks Again"

Socialists.... Last year they were complaining how delivery people weren't getting paid enough. Well, I can tell you they certainly won't get paid more now.
Tell that to companies like Netflix: https://www.phoronix.com/scan.php?page=news_item&px=Netflix-...

Not all applications require Docker.
> gaming for one, requires the source to be secret, or else you'll allow anyone to build and release the game easily and thus not recuperating costs of production.

The engine is not the game, it's missing all the assets (3D models, textures, audio, scripts, etc). The assets don't need to be GPL-licensed.

Most games use one of the few popular game engines: Unreal Engine, Source or Unity, which while not being open-source, are available to anyone and make it possible for anyone to build and release games with them. That doesn't stop them from making money.
As more of them die, grocery workers increasingly fear showing up at work
Smallpox may have gone but I'm fairly sure that there was a vaccine for that a very long time ago.
As regards extreme poverty, I don't know that the situation in sub-Saharan Africa has improved, it may even have become worse.
But I'm not doubting that there have been massive improvements in a qualitative sense to such an extent that in some ways they are revolutionary.

The 50 or so years from about 1895 gave us powered flight, radio and television, the first antibiotics, nuclear energy, rockets capable of escaping earth orbit, the big bang understanding of the origins of the universe, motor cars and even car phones. They also gave us two world wars which may be significant. By comparison the last 50 years appears rather dull, from this layman's perspective.
For me, Prime Now's been dead for days.

Instacart? INSTANT order assignment and food within 2 hours. I was stunned. Also no item limit like in Prime Now. I got 8 cheeseless pizzas. '<'
Exactly. People are learning to use Amazon for things they may have not used it before. And it's not just Amazon. HN users are by and large very technical and early adopters of tech services. The pandemic has forced the general person to learn how to use/try out these services.
If "collect data about users" is supposed to mean "how many users", then maybe amend it to say "collect data (only) about the number of users"?
Anyone know what mechanism this test uses? I didn't see it in a skim of the article.

Saying this because viral load seems to be peaking in the upper respiratory on _day one_ of symptoms, and quickly decreasing from there as it moves to the lungs.

But maybe if this is an antibody test, that won't matter?
GCC doesn’t enable -fdelete-null-pointer-checks until -O2, so even -O1 might work fairly well.
The problem is not availability of cheap airline tickets, it's availability of healthcare.

The point (the transportation/energy use issue cannot be tackled without also working on the social problems) is an important one though.
It asks you during setup if you'd like to disable it.
>> More like a railroad (of darks past) or electric/cable company. A utility.

If people take this literally then there will be strong push to nationalize it or break it up. I'm not sure Amazon wants that feeling...
I have crappy wi-fi in my bedroom, but I'd still prefer that apps update themselves while I'm asleep.

The 5 am thing is actually perfect for me. I get to use LTE when browsing around at night, but it still downloads app updates over (slow) Wi-Fi in the early morning. By the time I'm awake around 8 am, it's all updated.

If you don't want to auto-join your wi-fi network you can change that in Settings for your network.