skysight-inc/HackerNews huggingface dataset:
This study is specifically about patients sick enough to be put on oxygen. The top ranked comments don't seem to address that detail.

Some thoughts:

My understanding is this is a powerful alkaloid. My experience has been that similar compounds can help combat inflammation. They also can work to help kill infection at times.

By the time people with Covid19 need oxygen, inflammation doesn't seem to be the primary problem. So I wouldn't think it would be particularly helpful at that point.

Ventilators get prescribed in part on the assumption that inflammation in the lungs is a major impediment to getting sufficient oxygen. Ventilators are failing at a shockingly high rate, with a death rate up around 80% or so. Some doctors are moving away from ventilators because the death rate is so high.

I spoke recently with a researcher who suggested impaired vasodilation was a possible explanation for the reports of low oxygen combined with a surprising lack of pneumonia and inflammation in some cases and that makes a lot of sense to me. The mechanism causing low oxygen does not appear to be the obvious answer of "lung inflammation and pneumonia."

That doesn't mean this drug can't play a meaningful role at some stage. It mostly means it's not the magic bullet solution for advanced cases that they were hoping for.

This in no way surprises me because the things it actually treats do not appear to be the cause of low oxygen in advanced covid19 cases.
More like a big ad for them, because everyone is going to hate the state here, when there is one more month of lockdown and many people rely on amazon for distraction.

Also, there is no "real" competitor, and even if there was they would also need to limit their offerings the same way.
Next generation smart HDR is a big upgrade. The new chip will be able to run the new image processing algorithms based on deep learning which gives you photo quality bump similar to a better camera
One common beginner mistake is attempting to modify files in the immutable store directly. Don't do that. The system is read only for a reason.

Also make sure you allocate enough space on your root partition so you don't have to run garbage collection all the time.
Heh, I felt bad after it is clear you are trying very hard to be fair yet firm. Kudos for all you do!
This isn't left vs right; it's an unqualified politician vs pretty much all of the scientific community.
Probably a lot less:
141 million tax filers * 92% under 130k * 2000 = ~$260 billion
How to Get Him to Treat You Like a Priority
Notably on Feb 4th China announced their researchers were recommending testing chloroquine, about a month and a half(?) before Trump mentioned it:

http://www.whiov.ac.cn/kyjz_105338/202002/t20200204_5497136....

https://www.nytimes.com/2020/02/06/health/coronavirus-treatm...

https://www.nature.com/articles/s41422-020-0282-0

This was the original study which I believe influenced the French study and Dr. Zelenko (who seemed to be the nexus to Trump).

The UK banned export of CQ around Feb 26th (I believe the first country to do so):

https://ihsmarkit.com/research-analysis/uk-bans-parallel-exp...

From Google's custom date searches is looks like Trump first mentioned it in a press conference on March 19th:

https://twitter.com/cspan/status/1240672025989001221
You're right. In practice I usually C-/ (undo) C-g / (redo) to get back to where I was; which is something you can do after you've lost your place in the file, but it assumes to previously made some change in that location.
I just read his wiki, what influence did he have over pricing? Like, design wise this all seems on brand but it feels like maybe it be a different part of the business for pricing. But, i have no hardware experience or knowledge
https://grahamc.com/blog/nix-and-layered-docker-images
Not a clue yet. The Pixel 4a looks promising, but is once again huge. It's for my wife, so it might come down to whether she prefers that jack or something that fits in her hand, but I'm in this thread to google the other phones here and hopefully find something that checks both boxes.
Probe unable to rule out influence on Jedi contract awarded to Microsoft
On the SSD side of the storage market, I know it's becoming more common over the past ~2 years for manufacturers to change drive internals without changing the model name/number (for consumer drives only). In the past year, I've had one brand proactively bring it up as part of a product announcement presentation and two other brands have mentioned it in the course of an extended conversation about their entire product line. For the one company that mentioned the hardware update in their press release, I asked if they could get me a review sample of the new revision, but the drive that arrived a few weeks later was the old version.

Most of the updates like this in the SSD market are actually pretty harmless—switching a SATA drive from 64L to 96L TLC generally isn't going to change the performance or power characteristics enough to care about, and is more likely to be beneficial than harmful. But when they start introducing QLC NAND into a product line that originally was TLC-only, that's a problem.
I agree, but I would put it differently. It is a lot easier to advocate a conclusion with full control over the assumptions, than discovering the boundary assumptions where the opinion no longer holds.

For example, it is easy to argue for "HTTPS is more secure than HTTP". But what I am often interested in -- as a curious and skilled IT person, and not a lambda user -- is what attack models does HTTPS defend against. Remove assumptions one by one, when does HTTPS offer equivalent security to HTTP.

This is not just nitpicking, but extremely relevant for our profession. TLS has gotten under quite a lot of fire lately, so sooner or later, someone somewhere will discover those hidden assumption. I rather it happens on a public forum.
There is a well-known piece of software (JSLint) whose license says that it shall not be used for evil.

The author wound up having to give an exemption to IBM or its minions. See https://web.archive.org/web/20170722132351/https://dev.hasen....

Before you laugh too hard, remember that IBM's tabulating machines were used by the Nazis for the holocaust. And IBM's customers include a variety of dictators who are trying to keep tabs on their population. As an institution they have extremely good reason to believe that their work will be used for evil.
I don't get why you would spend time leaving this comment.
According to Donald Trump cloroquine can also be referred to as hydroxy chloroquine. You can watch here https://youtu.be/3GuNbGC2D_8
fictional -> fiction
During the H1N1 crisis France made a strategic reserve. Latter governments reduced the inventory. It was not renewed in the end.
Main thing for me is size in the hand and squared off sides. I find anything with rounded edges I can't hold on to and just hits the floor constantly... little better with a case, but that makes the phones just that much bigger and less comfortable. I can't bring myself to let go of the old SE's.... of which I keep two around just in case.
The post covers all the points you mention. The benchmark only covers Redis forks so it doesn’t get a whole lot more apples-to-apples than this.

> So there are 3 offerings by 3 companies, all compatible with eachother and based off open source Redis: Elasticache is offered as an optimized service offering of Redis; RedisLabs and Redis providing a core product and monetized offering, and KeyDB which remains a fast cutting edge (open source) superset of Redis. This blog looks specifically at performance, however there is a section at the end of this blog that also outlines other key differences.

The last paragraphs give a good overview of the differences.
I have met people who are so focused on business/money that I find them repulsive. At the same time, I know some geeks who are the most bitter and angry humans ever. Even when they consider you smart and let you in their inner circles, all they do is complain about un-worthy developers or managers. It gets draining.

I am too old to hang out with negative people, also too old for people who are only interested in making money. So I searching for a new tribe, I think outdoors people are the happiest bunch. I just don't know what can I do.
Ah, I see. Is it true that these tests are a work in progress and the false positive rate will drop in the coming weeks/months? If so, it seems like we should start doing random sampling and saving the samples for future testing (so we can see how infection rate trended). This could be invaluable data that we're losing.
Neutrinos could shed light on matter-antimatter imbalance
[can't add comment to your old post]

1. org-bullets
2. it seems like a bug with performance for long lines in emacs
(at least it was in my case)
3. there is no size fits all: my org file are header, code blocks -heavy
lots of hierarchy, tags, properties; yours may be completely different
4. refilling works via narrowing the list of candidates using ivy
(it the same interface used for switching to a project, opening a file, switching to a different buffer, running a command, etc)

5. https://emacs.stackexchange.com/questions/5889/how-to-highli...
also put sugar in, amount to taste!
Show HN: Animal Crossing marketplace built with ReasonML and Dark
Unfortunately, COVID may also be associated with hypokalemia, so even patients without comorbidities could be at risk for TdP. HCQ may have therapeutic or prophylactic benefits, but it’s definitely not without serious risks.
I actually thought it did say "Nutshell" when I read the title. When I clicked through to the actual page and saw it was "Nushell" I came back here to verify. :)
This was what made it all make sense for me:

https://perl.plover.com/Regex/article.html
Nah, the idea that "one that's mentoring those around them to do their job well" can lead to promotion is also just an example out of many.

My experience is that the biggest promotion driver is always the product success. And the product success also vary between organizations. I've seen a huge project promoted people in the process, but in the end was entirely canceled and delivered minimal value, while the promoted folks wisely left the team. While in other places, if the product ends not getting their customers happy, execution excellence is not rewarded much.

If product success is not easy to get, the team can be very excellent, but wont have much growth space in seniority. That has nothing to do with their personal skills etc.
Ah shoot, I wish I had known they were bringing touch ID (and the home screen button) back. Not a fan of Face ID.
If anyone pays a million less in taxes then someone gave them a million dollars back. so yes, you are giving them something. One can argue in some irrational way that taxes are theft so you never 'give' someone something if you reduce their taxes. At the end of that game, you have more money than you had before, gift or other political arguments aside.

Someone who was going to pay a million in taxes and now has 1 mil less is not going to put their money into the economy the same what that 1000 people with moderate income, like say restaurant workers getting $1,700 would. Those people poorer will spend all that money. I'm fortunate to be a well compensated software engineer, and I pay a huge amount of taxes. I'm not out there begging for more money (via tax reductions) and then claiming it was already my money, not a gift. That's a dishonest argument.
Pstress: Database Concurrency and Crash Recovery Testing Tool
That is a good point. The uptick in downvotes I see could maybe explained by the topic's high profile and divisiveness, instead of astroturf. But, that still leaves the question as to who is in favor of the CCP? Or is it just a reaction to short, dismissive posts on the topic? Must be interesting as a mod to get to quantitatively analyze these questions!
Both, I guess. For repeated tasks, there are times when I need to take over something unexpected. Are you accounting for all calendars in the view or just the logged in account?
you can make that salary at a big tech company
> The marketing around Product Red are that you can buy the same product you want in a color that you want

So you can buy a space grey iPhone from Apple and support Product Red? This I was not aware of.
Great question, and the one I struggled with a lot. When I finally saw the light it was like find the glasses I have misplaced three days ago. Here:

1. Efficacy of a test can only be judged against specific priors, not any possible circumstance.

2. Likewise, the goal of a test is to assist in making a particular decision, not all possible decisions.

Specifically 9% false positive rate is not useful for testing general population where effect size is expected to be on the order of 1-10%. However it is very useful in testing groups where expected effect size is much larger for example "all symptomatic people who came to hospital" at 50% or "all contacts of a known case" at 20%. The numbers are made up to illustrate the math.

Importantly our goal is not to detect all infected people ending the epidemic in XYZ days flat, it is to reduce the viral spread factor below 0.5, halving the epidemic every XYZ days. Thinking in absolutes is counter-productive.

Bearing all this in mind, the test can be useful. For example let's take a pool of people who are symptomatic, and say we expect 50% were in fact infected. The false positives (9% of the healthy 50% == 4.5%) will be outnumbered by true positives (* 99% of the infected 50% == 49%). So now you're looking at 49% vs 4.5%, a respectable 11:1 accuracy under the given priors. Not bad, for some applications.

And here's one good application: test a group of people from the pool of the currently symptomatic, quarantine them for two weeks, then release them into the wild without self-isolation rules. They will all be healthy due to quarantine, and 10/11 will be immune. If we keep releasing 91% immune groups of people into the general population the virus will die off.

* the antibody test I was referring to has 99% true positive and 9% false positive rates.
For one thing, with Oh My Zsh, you can use nice themes like this: https://github.com/agnoster/agnoster-zsh-theme

Zsh have a long list of nice features that Bash lacks. Two of my favourites:

1. Imagine you are in a directory with file1.ext and file2.ext. You type f[TAB], it autocompletes it to file. So far, Bash and Zsh are the same. If you continue pressing [TAB], bash prints a list of files so you can complete typing the name yourself. Zsh starts cycling through filenames.

2. In Zsh, you can type for example /u/lo/b[TAB] and it automatically expands the path to /usr/local/bin. If multiple paths match the original expression, it shows a list and pressing tab cycles through the options.

Zsh is quite feature-rich, and for the most part a drop-in replacement for Bash. See this slide deck for more Zsh awesomeness:

https://www.slideshare.net/jaguardesignstudio/why-zsh-is-coo...
People also argue that the earth is really flat, that tax reductions always pay for themselves, and your comment is equivalently powerful to those.
It could be something physical. My sense was it was something else in Lee's case: a change in his routine. I think the routine of coming into work kept him in a pattern that kept him from deteriorating quickly (or, at least, kept us from recognizing his deterioration). When he had heart surgery, he took several months off to recover. When he returned, he seemed dramatically different. I also noticed a dramatic change immediately after he took time off for his wedding/honeymoon. And, after he left Cloudflare, the article talks about how it seemed like the effects of the disease accelerated. I'm not a doctor, and there very well may be some other connection, but my sense in this case was the routine of work actually allowed him to hold the effects of the disease off and, at those times when he didn't have it, those effects accelerated.
How to manage Slack and email for laid-off and furloughed workers
Very well put (deliberately using the exact terminology used in the standard)!

Can we just make that binding again? After all, it used to be.

It should be obvious to compiler writers what the intention of the standard is, because it says so in the dang text, but since this was downgraded to a note and you are technically not in violation if you do something different, everyone now acts as if doing the exact opposite of what is written there is somehow OK.

The downgrade to note-status seemed to be predicted on the idea implementors can be trusted to do The Right Thing™ in these cases. It is now evidently clear that they cannot, so we have to force them.
Analyzing the 8051 USB firmware of a gaming mouse
I’d never used a case until I got the iPhone 8 and had to buy one because of how slippery it is! Unless you put it on a perfectly flat surface it will just slide off on to the floor.
Meh, it's been my experience that those charts are borderline worthless. The truth is promotions are probably only fractionally about performance. A lot of it is budget, creating pr/"buzz" [even if it's proportional to impact], did you happen to be on a revenue-generating team, is there any political risk to promoting you (e.g. would you say the type of things I'm saying right now?).

Maybe google or something is different (and I doubt it), but that's less than 1% of engineers.
I would like to add Nhost to the list (https://nhost.io). You get GraphQL API (hasura), PostgreSQL, authentication, and storage. Everything managed for you.

We started just a few months ago, but are already getting very good feedback from our customers.

BTW, we just released a CLI to make local development easier, check out the companion blog post here https://nhost.io/blog/announcing-nhosts-cli.
"What do you have to lose? Take it,"

"I sure as hell think we ought to give it a try."

"one of the biggest game-changers in the history of medicine"

"I want people to live and I’m seeing people dying and I’m seeing people who will die without it,"

These statements are just the tip of the iceberg when it comes to endorsements by Trump.
Well know quack Dr Joseph Mercola has been pitching this for a couple weeks now.
This is a pretty reasonable thing to suspend at a time when landlords are essentially forgiving huge amounts of rent. It's super reasonable that they be able to deduct those losses on their taxes in an unlimited fashion.
> A proven successful use of this drug would be very inconvenient for multiple media outlets who jumped at the (described as) unfounded claim.

Eh? Even if it did turn out to work, it would still have been an unfounded claim for Trump to claim it did without evidence, and a stupid and dangerous thing to do. That's what 'unfounded' means.
My mother, a pharmacist by training, has repeatedly communicated her impression that "this whole coronavirus thing would be gone in a week if we just gave everyone HCQ!"

She got that impression from somewhere, but certainly not from any of the studies I've read, leaving the conservative news sphere as the likely source. Whoever is making the exaggerations, they're egregious.
The history of rushed vaccines is not good. The first attempt at a polio vaccine was rushed through with inadequate safety measures and resulted in 40,000 children getting sick, some with permanent paralysis.

There are good reasons vaccines take years to be approved. I’m very worried we’ll see a repeat of historical mistakes in the current rush.

https://en.m.wikipedia.org/wiki/Cutter_Laboratories#The_Cutt...
We currently look only at the logged in account, but we have been toying with the idea of looking at both your personal & work calendar -- especially during the current WFH times.

Out of curiosity, how do you currently handle the case of your calendar being open, but not being free? Do your colleagues book the meeting anyway and then you let them know that they should reschedule because you're busy?
I think it's a little unfair to blame developers.

I see the problem that our tooling is diverse and assembled from parts. You can pick a compiler from column A, a version control from column B, and GUI framework from column C, a message queue from column D, etc. And somehow, it's is possible to make them all work together. We love having that flexibility and choice.

But we pay a price in the added complexity of making all the pieces play together. A sibling comment mentions Turbo Pascal, as a contrast to today's programming environment. Yeah, Turbo Pascal was great, but it was also an all-in-one kit: you couldn't even use your own linker, you had to use the built-in TP linker. In a sense, it was a walled-garden Apple-style development environment. But it worked, it was easy, and it was fast.

The closest we have to that today is Visual Studio. I'd argue that the (mostly) all-in-one nature of Visual Studio and C# relieves a lot of the headaches of the more traditional open source toolset, at the expensive of less flexibility.

This is not an argument in favor or against the Microsoft world, just an observation.
In 6 home classrooms, families try to keep coronavirus learning alive
> The full cycle was 18 hours, which meant the timing of our circadian cycles were constantly changing.

Living on an 18-hour day is rough, but I always felt that the worst part was changing back and forth between a 24-hour day and the 18-hour day. There are a couple of strong feedbacks to help you with the 18-hour cycle.

> The bunk rooms are sanctuaries where silence is observed with monastic intensity.

Not merely silence, but also lighting. The bunk rooms are always lit with dim red lights, and the working spaces are lit to nearly full daylight. On the older boats you would also operate the control room at periscope depth with dim lighting, but newer ships with electronic masts probably don't.

Diet-wise, the ship serves four meals a day, every 6 hours. Midnight rations or midrats is the fourth meal. So in a good rhythm you can eat when you wake up, go on your 6 hour watch, eat once more, work/train for 6 hours and sleep/personal for 6 hours. Eating your prior meal about 12 hours before you wake up also helps keep a decent body clock.
I think this is a great example of how to take a fairly complicated topic that goes deep, and progressively build an understanding with successive refinement of examples. They way the paper goes from the "what" to "why" is really well thought-out.
> I honestly didn't follow your Google search/wifi example.

Sorry, wasn't clear there. I generally don't think the 'match' thresholds need to be that high for effective (in terms of dollars earned vs spent) targeted ads.

In the google example: if a friend comes over a searches for designer watches odds are the whole IP/home is a decent enough target for designer watches.
It's more complicated than that: Emacs packages should be thought of the same as any other language's packages. They might comprise multiple files, and it's possible that their performance will be noticeably compromised if they are not byte-compiled. Installing Emacs packages should be done with the package manager.
> One approach to saving weight while increasing telephoto reach is to use a smaller sensor

I make a 'soft' change to the the sensor size on my Nikon D850 by switching between FX (full frame) and DX (crop) mode. DX gives me a 1.5 effective multiplication of the focal length, but a still very good resolution of 5408x3600 pixels (uncropped FX is 8256x5504).

In some shooting modes (e.g. slow motion video at 1920x1080;30p x4) the camera automatically switches into DX mode, presumably to maintain a high framerate for a sustained period. I've now learned to select a DX crop in advance if there is a chance I might need slow-mo so that I don't get a jarring change in effective focal length mid-way through a shoot.
> For a quick start we recommend you to read our book

That... is not a good way to entice me to try something.
Which is why employees are disincentivized from trusting those managers.
Shameless plug: https://github.com/rmpr/atbswp, is a mouse and keyboard macro recording and playback tool, think about it as some kind of frontend for pyautogui.