skysight-inc/HackerNews huggingface dataset:
Correct me if I'm wrong, but this used PCR testing to determine the number of _currently_ infected people. It says nothing about the number of people that _were_ infected, but fought off the virus and are now potentially immune.
Can anyone explain what a "genetically transmitted neurodegenerative prion disease" is? I thought prions were misfolded proteins found in the wild that had to be ingested in order to cause disease. How can they be genetically transmitted?
Market rate for junior + training while he/she is junior is not more expensive.
You just need an older version of the Kindle desktop app that doesn't support the newer (uncracked) DRM. Then you just download the books you've purchased in the app, load them into Calibre, and De-DRM them.
I get this reference.

But it seems unlikely unless the correlation between preventative measures and drops in cases is coincidence.
Ghidra and IDA's decompiler are fairly similar in my experience. There are some specific situations when one is better than the other, but overall both do a really good job at recovering the control flow. One thing IDA has that I miss from Ghidra is a way to split/merge variables from the UI. In IDA, I can tell the decompiler that two variables are actually the same, and it will merge them.
And perhaps ditz¹ [+ pyditz²], BugsEverywhere³, git-issue⁴.

As someone who -- I guess obviously -- cares about distributed issue tracking, I really like the direction and implementation of git-bug. The termui subcommand is really cool, and it appears to be enough to push co-workers to try it when they normally push back on "weird" tools.

I think the closest we had to user friendly before was the read-only web interfaces in ditz and BE, but user friendly isn't all that friendly if it is read-only.

1. https://rubygems.org/gems/ditz

2. https://pypi.org/project/pyditz

3. http://www.bugseverywhere.org/

4. https://github.com/dspinellis/git-issue
The inconvenience of using a distributed bug tracker all year round must be much worse than taking a small break when Github is down.
For $1500 you could hire someone to come over and put a new newspaper into the frame from time to time.
I'm not the person you replied to, but you might want to check out The Mind Illuminated by John Yates, a modern meditation guide (based on Buddhist practices) that delves deeply into mind's systems of attention & awareness.
Covid19 free and open datasets of patent documents and scholarly research works
"Provably less qualified" means a cheaper hire so yeah many reasonable companies would choose that option. It's good to remember that you can easily be overqualified.
A code formatter knows, so your editor and other tools can also know.

Most editors have code structure parsing of some kind built-in for tabbing already. E.g. pressing the <tab> key indents the current line to match the structure of surrounding code (or cycles between valid indents for something like Haskell or Python). So they know the difference between initial indentation (that people want to be able to configure visually) and alignment.
Spread rate would also need to stay in a certain range for a virus to stick around. Spread too fast and there won't be a second wave. The herd immunity effect gives this system some self-balancing properties, but there's surely a tipping point where even that won't help a speeding virus to survive.
like many folks have already shared...

... the process is sometimes the real lesson-learned.

don't beat yourself up about NOT finishing stuff. sometimes, that's just as good as finishing.

the goal is learning, not necessarily profit.
The Boox Max 3 seems to be a better option for the OP. [0]. It has a 13.3" screen, runs Android, and also functions as a monitor for your computer. The refresh rate doesn't seem to be the best, but it looks like a pretty good solution given what is out there so far. I've been looking at it for a while, but I haven't bought one yet. I would love to hear opinions by people who have one.
[0] - https://www.boox.com/max3-3/
i actually like middle-click paste, but there's no denying that having two distinct OS-level copy/paste buffers with subtly different semantics is a rough edge.
The price filter does not seem to work (maybe the minimalist one neither, but not totally sure). I selected <1200$, saved it, the page says <1200$ but I see 7000$+ paintings.
I know it's in bad taste to get political on HN, so I won't say any names, but yes, this is very true of every "Make X Y Again" thing I am aware of.
My last job involved a little bit of react, my current job is mostly react.

For my side projects I am using Vue and Vuex. One of these days, I am going to find a reason to start using MobX at work.

I think lessons learned are transferable between these frameworks so that picking one and doing something with it is more important than which one you'd pick, but I would stick to something in the React-Vue-Svelte family.
According to the Heinsberg Study in Germany, the infection rate was as high as 15% and the mortality rate in the town would be as low as 0.37 per cent.

Germany launched the Heinsberg Protocol study to examine the rural town of Gangelt in the region of Heinsberg, where the first virus fatalities occurred.

https://www.thenational.ae/world/germany-s-wuhan-has-15-per-...

During recent weeks, his team completed substantial research conducted through surveys and investigations in homes across the Heinsberg region - where more than 1,400 confirmed cases had been reported. Heinsberg has an approximate population of 250,000 inhabitants and has confirmed 46 coronavirus-related deaths.

These research findings have already provided some indication on how the virus works, as Streeck clarified:

“There is no significant risk of catching the disease when you go shopping. Severe outbreaks of the infection were always a result of people being closer together over a longer period of time, for example the après- ski parties in Ischgl, Austria.” He could also not find any evidence of ‘living’ viruses on surfaces. “When we took samples from door handles, phones or toilets it has not been possible to cultivate the virus in the laboratory on the basis of these swabs….”

“To actually 'get' the virus it would be necessary that someone coughs into their hand, immediately touches a door knob and then straight after that another person grasps the handle and goes on to touches their face.” Streeck therefore believes that there is little chance of transmission through contact with so-called contaminated surfaces.

https://today.rtl.lu/news/science-and-environment/a/1498185....
Please note that how useful the results of that study are is widely debated. Not much detail about the process has been published, it's unclear how reliable the tests used are (other experts say they will likely also trigger for other Corona-viruses) and how representative the sample is (e.g. they did look at individuals, not households).
The Race to a Billion Users: Investing in the Indian Blockchain Ecosystem
+1. One of the best courses I took in Coursera, especially because my background is in Engineering, not Social Sciences.
If B2 and D4 are positive, then in the marginals B,D,2,4 will show positive, but you don't know which of B2, B4, D2, D4 are positive.
The paper is comparing to "clinical estimates", probably those estimates already tried to take this into account?
Defold – The ultimate game engine for web and mobile
SIMD instructions
But Chrome already has a stranglehold on the majority market.

In my opinion, Mozilla should put the vast majority of their energy and resources towards targeting power users and developers - they've already lost the other battle.
I'm quite interested in the subject matter here but jesus that was long-winded...
Stimulus Reflex 3.0: Build reactive applications with the Rails
Braid – A team-chat app with a novel UI for better conversations
Examples or they don't exist. :)
This is neat, but a little scary. If I'm understanding it correctly, they are checking sewage for evidence of the virus, and estimating how many people have it based on that. This would be really cool if it were common place, and tested for all known viruses, drugs, fungus, bacteria, lead, whatever they can find. This could be used to track the health of the population over time and as it spreads. If it were publicly available this would be a great resource.

The scary part is what if they start making the sewage sites smaller and smaller, or even just the collection locations to where its testing fewer people. Then use that information to enact quarantines or investigations.
I was just having trouble focusing on the screen. My eyes would drift out of focus. It was physically uncomfortable to force my eyes to focus. So I wouldn't. But for my work I would feel like I had to at least try.

For context, I had been going through some burnout. So some part of this was probably psychological. But I would look at the screen and just feel overstimulated. Like my brain wouldn't let my eyes focus on that bright little rectangle any more.

This thing is just much more gentle to look at.

The sense of physical relief is very similar to the sense of relief you'd feel when moving from a bright screen with no blue light filter to a nice warm screen.

(Assuming you have comfortable lighting in your environment, of course.)

You can try this at home:

1. Stare at a page of a book

2. Stare at a light bulb while it's turned on (just kidding don't actually do it it's not worth it)

Which one would you rather do for 8 hours a day? I don't blame you if you say "neither one".
Traditionally middle managers are added to facilitate coordination. Today we can expect more of our people, and we have great tools. When moving towards higher autonomy and transparent shared communication most of the coordination and communication traditionally done by middle management is no longer required, and will instead run p2p between the devs while being shared and documented on the asynchronous shared communications platform (not email!).

Many middle managers have been moved into that layer from technical roles. They are often happy to return to more technical work.

In my projects I don't use a middle layer. I have the technical people who have the core scientific/development/production skills and I have a final decision layer of those who by reality have the final say over how money is spent and which goals to prioritise.

This has worked very well up to about 50ppl with exceptionally low overhead. That said, would not try this with people I can't trust. But I would never hire people I can't trust.
On the graphic it's "29% of todays tests were positive", not of overall tests which indeed stands at 19.94% positive (18941/94958). The graphic is incorrect with 16% of all tests positive.

EDIT: Creator of the graphic is /u/oldgrimalkin who posts these each afternoon in /r/CoronavirusMa
@flarg, just curious, why do you need a Plant UML replacement? I just used it to make a bunch of séquence diagrams, component diagrams and wireframes :)
The Anxiety of Learning (2002)
It can't run in the browser which makes this a non-starter.

It also can't make efficient use of resources, which explains it's lack of prevalence in embedded/back-end apps
I would refer you to New Zealand which has, last time I checked, had one infection and zero fatalities. Sure this is not "preventing any infections" but I would argue that the rounding error on this is sufficient to make the claim that some governments have reacted well and the United States government has not. Of course NZ has several advantages geographically, but they also have a competent government that was willing to take proactive action.
Maybe it works for only the chosen ;-)
I think that requires an antibody test
This is exactly how it worked in Photo Booth on OS X over 10 years ago. It was good enough for short clips, but not reliable for long sessions.

Random example clip: https://youtu.be/T5uqB1Kqukw
Same concepts for the most part. I think K is a bit easier to understand and if you're lucky enough to work with a kdb+ system, I'd focus on k & q to be honest.
I don't see how this theory would be compatible with the rapid rise in hospitalizations and deaths that was observed in the last weeks. If many people had been infected a long time ago, why are they only now starting to get sick?
If you want classes that are more advanced or that go into greater depth, I recommend the courses offered by edX or Stanford-online or MIT OpenCourseware. These are full-term for-credit courses with video lectures at top schools that you can 'audit' for free, though few or none will grade your homework or projects unless you pay full tuition. By contrast, 95% of Coursera or Udemy courses are much shorter and more introductory.
US officials knew of Wuhan health crisis in November, a second report claims
As is often the case, this review can be recommended instead of the book; anyone who still wants to read the book after the review, is quite likely to enjoy it.
Also a plug for https://nbdev.fast.ai/ which lets you run tests, produce documentation and version control notebooks.
So the decompiler is not included?
Google Stadia is now free for everyone
Safety data can be gained from epidemiology studies. There is more than one way to work out if a treatment is safe and effective.
I realize that your comment is tongue-in-cheek, but if the situation were so (or just if there are a great many asymptomatic cases), then the continuing rapid increase of symptomatic cases would indicate something rather unusual, including, if I am not mistaken, little immunity, in many cases, from a first infection, and second infections being more serious than the first. I vaguely think that there are some diseases like this (or perhaps I am just thinking of allergen sensitization.)
Ghidra is better than IDA for almost every use case I've found. I was working on reversing a bunch of mipsel binaries; Ghidra's decompiler worked, IDA didn't. I also tried r2 with Cutter, which did a decent job and had by far the slickest UI. Just my two cents.
You’re fairly hard to get in contact with directly. Would you mind sending me an email? I don’t think I’ll be a your “middle hop”, but I’ll try. My email is lyndsy@<my_HN_username>.com

My username here is my real name, and I should be easy to find. It’s also my username on Twitter, Keybase, and most other popular platforms.
Great read!
I am curious then why the Linux client doesn't supports this, if all it takes is to send out our webcam stream data to be processed server-side?

P.S.
What happens when they do e2ee on the webcam stream?
Any previous solution to do UI: QT, GTK, WX, etc were cross plateforms.

I don't think that's it.

Electron make it easy, if you know front end dev, to do an app. It's easy to package as well.

I don't know if you tried to design a beautiful QT app, but it's hard. A beautiful QT app with medias capabilities ? Extra hard. Packaging that? A royal pain.
What is funny is I had spent more than half of my career working in the SEO space building "efficient," "high-scale," "single server" web applications, because people don't want to have to hire teams of people to manage all the different "-ops" that go along with the modern, micro-service, distributed architecture that is unnecessary 90% of the time.

All of those quotes were because they are all relative terms. Like high-scale meaning 10,000s of concurrent users; and single server for the web app (separate database server, or utilities server for cron jobs, offline processing, etc); and efficient meaning nothing really.
1-Day Smart Contract Security Reviews
I submit this for discussion for I worry that in our current self-isolation due to the endemic, could we self-impose coersive persuasion that make us even more isolated from the society and the reality?
SwiftPlayground-Pharo: Interact with Swift on Pharo
There are so many things conflated here that there's no reasonable way to say that these are the things that prevent 'parallel processes' (which it itself is a misnomer, processes are how to get concurrency with python).
Also, according to [1], only a third of throat (pharyngeal) swabs from patients known to have the virus were positive.

1: https://www.jwatch.org/na51116/2020/03/17/pharyngeal-and-nas...
Ah sorry, I did not catch that you were talking about pure cloud storage solutions.

Yes, I have a remote VM where I can ssh and use it as a borg server.

The advantage I see in this vs a copy of the repo is that I have two independent backups. If one fails for some reason (defective disk for instance) then I do not copy a faulty backup further.
There's some places doing blood testing and it looks like it is going to be about the same:

https://www.sanmiguelcountyco.gov/590/Coronavirus

Very few positive PCR tests, very few positive blood tests, so not as interesting as blood tests in a region with more positive PCR tests, but it demonstrates there's not a big group of people in the county that have immunity.
Not exactly, but the rebuttal includes:

"As of 2nd March 2020, there are 111 nonsynonymous mutations that have been identified in the outbreak, these have been catalogued here in the CoV-GLUE resource 504 and can be visualised in Figure 1. At current, there is no evidence that any of these 111 mutations have any significance in a functional context of within-host infections or transmission rates."

The premise that there is an "asymptomatic strain" is still theoretically possible but unsubstantiated, despite ongoing investigation.

> "I can’t believe that a month later, this bad science is still being circulated, by a purported PhD and former professor. "

That strikes me as a bit harsh, given that the posted article doesn't actually rely on two-strain to make its case, just the idea of functional variants possibly being out there somewhere. MacLean's rebuttal didn't definitely exclude the possibility that there's some functional variants out there somewhere, we just don't know, haven't seen it in anything we've catalogued so far.

Science is often about calibration. I wouldn't say a search for functional variants is completely worthless. That's why researchers continue to look at variants. On the other hand, completely agree it's overselling to pitch this as a silver bullet for the whole crisis though. Research can be important even when it doesn't solve for everything.
Indeed PCR tests only test for the presence of the virus itself. Their big advantage is an extremely high specificity. Antibody tests are plagued by large numbers of false positives.
Show HN: Developer friendly note taking PWA
It was the panic from the rest of the world, at the beginning of March it was business as usual. It became real when Italy locked down its people.

During SARS-1, I was in high school, and there was no major panic outside of downtown. I don't know about internally, so perhaps the hospitals were better prepared because of it this time.
It is somewhat, yes. Or I could cause gradual cell death in someone's brain. Same idea.
I have suffered with a fair bit of general anxiety my entire life. I'm 39 and while I'd say that I am significantly better at coping with it... it's still something that I struggle with and am still learning to deal with better.

I am not quite sure if you meant this post from a general "world at large", or from a "professional having a hard time with work" perspective. Or both? So the things I am about to say are from the "professional having a hard time with work" perspective as it's the one I personally struggle with. I'm sure some of this is applicable to the other category too.

1) Form routines, especially for stuff that generally spikes some anxiety for you. Figure out a process and just do it each and every day. I find that this helps with confidence.

2) Learn to say "fck it". Weird as it sounds, but learning to let go is an amazing tool. "You know, this situation could be better. But you know, fck it! It could be worse, so It can't be that bad"

3) Organize and plan things out. Prioritize things. Accept that you can't always tackle all issues. Use a todo app and list out everything you have going on for the day. As new things come up, add them as a todo. Keep the list prioritized and just focus on the highest priority item at the moment.

4) Learn to tell people you can't help them right now if it's not a higher priority than something you are currently doing. I struggle the most with this one. I always end up feeling really bad if I don't immediately drop everything and do whatever I can to help.

5) Close all those dang browser tabs. I'm sure you meant to come back to X thing 3 days ago... but honestly, it's just a distraction. Close all your random applications down. Open a fresh browser window and only have the stuff you need to focus on for the day. If something is really important, use a bookmark or otherwise take note of the page so you can come back to it later.

6) Medications are often useful tools and can help with improving your quality of life. It could be worth talking to your doctor. Medications generally don't solve problems, but if it can help improve your quality of life, it can be worth considering. It's also worth pointing out that it can potentially take a very long time to work out which medications are best for you. I take medication for high blood pressure for example. Having a lower blood pressure has also helped with my anxiety and just generally feeling better. This has also helped with my anxiety.
>You need to reconcile...

No, actually, I don't need to reconcile anything. I'd prefer to stick to the OP assertion. If flu deaths are similar to C19 deaths during mitigation, it is abundantly obvious that we've made a terrible mistake. You seem to want to litigate something. I want to do a t-test.

Of course if C19 deaths are 10x what the flu is during mitigation, and overall pneumonia deaths are much higher (aka we're not mistaking flu for C19), then shutting down the world economy was a good idea. I have no idea which thing is true. Your statements above indicate you don't either.

Are total pneumonia deaths (aka flu and covid19 summed up) bigger or smaller than in previous years? Presumably someone's tracking this?
You don't need a raspberry pi to run pihole...

I have it running in a vm on a machine that is on 24/7 anyways.

I installed dietpi as the OS and selected pihole in its install options. 10 min later it's up and running. No issues!
I was slightly younger than fourteen when my fifth-grade teacher staged a bridge-building competition in the class. She priced the raw materials (mainly toothpicks, glue, and string; I can't recall what the various exotic items were), and graded us based on ineffables such as teamwork and empirical metrics such as how much we spent on materials and how much weight the completed bridge supported.
I was thinking the same thing. Or you could get 10-15 annual newspaper subscriptions, delivered to your door/mailbox.
The articles author doesn't claim there are two strains. He claims there are many mutations. The link shared by the parent notes, "As of 2nd March 2020, there are 111 nonsynonymous mutations that have been identified in the outbreak". This seems to agree with the original article.

The article seems to work within the current findings of many mutations and different mutations have varying degrees of impact on people.
Just to add a bit more context regarding the now often cited study of Gangelt (some questions where raised re methodology and esp the policy conclusions):

https://www.sueddeutsche.de/wissen/heinsberg-studie-herdenim...

it is a good start & germany is doing now many more serological studies (also to monitor over time) and hopefully we'll soon gain more confidence re status quo and what it means
I can’t believe you think I am arguing for the “two strain” theory. My proposal has absolutely zero to do with two strains.
This behavior long predates Chrome and has been this way on other platforms IIRC since the browser was still called Phoenix, and probably inherited from Netscape at that; the change here brings Firefox's behavior on Linux in line with its behavior elsewhere.

I can understand how the people who develop Firefox think that's a good idea, but not how they imagine anyone wanting it other than themselves...