skysight-inc/HackerNews huggingface dataset:
To succeed in social, you need to exploit network effects to scale your user base. You might get a flash in the pan with some seeded content or go viral for a brief second. In the long run, you need to spend big and more than established competition even in niche markets if you want to create a beachhead. Even if you had the capital to do it yourself, you probably shouldn't since that's not smart in terms of risk. So then you will need to resort to investment from VCs (even angels can't fund a social product beyond seed). At that point, you have conflated your purpose from a do good-social enterprise to a venture that needs to provide 50x return for your investors.

Remember the value per user that acquiring companies pay for when they acquire said company and compare that to how much you will need to spend to acquire them from scratch. If you can't nail the distribution (sales & marketing) side of the equation, the product won't have a chance to get off the ground let alone survive.
That's odd. My experience with Firefox on Windows is that I can't get audio to work with Zoom. Jitsi, on the other hand, works perfectly though there is a small yellow box that warns me that I should use a "fully supported browser"
I was asking "robocop2018". Are you him?
Well, from the perspective of the client, yes.
T-Mobile, Sprint took a risk by finishing merger without Calif. approval
Note that they're carefully dancing around the elephant in the room: As far as I know, no one has ever demonstrated that Lyme spirochetes survive a course of standard antibiotics (Emphasis mine):

> Standard treatment of Lyme disease is oral antibiotics, typically doxycycline, in the early stages of the disease; but for reasons that are unclear, the antibiotics don't work for up to 20% of people with the tick-borne illness. One possibility is that drug-tolerant bacteria cause the lingering symptoms.

Many people experience lingering symptoms after contracting Lyme disease. Officially, this is known as "Post-Treatment Lyme Disease Syndrome". The CDC page for the PTLDS has more information: https://www.cdc.gov/lyme/postlds/index.html

These PTLDS symptoms are definitely real, but the idea that persistent lyme infection is the cause of the lingering problems is more of a hypothesis at this point.

It will be interesting to see if this new antibiotic produces different outcomes in PTLDS patients, but it's misleading to claim that this is the only antibiotic known to act on the Lyme disease spirochetes. The original study specifically explored the action of Azlocillin on Doxycycline-resistant spirochetes. From the study:

> Our results also demonstrate that azlocillin and cefotaxime can effectively kill in vitro doxycycline-tolerant B. burgdorferi.

The authors point to indirect evidence suggesting that spirochetes might still be present in PTLDS patients, but acknowledge that no one has yet been able to culture a viable spirochete from PTLDS patients:

> A recent study in humans demonstrated that B. burgdorferi DNA was identified in PTDLS patient by xenodiagnosis but unable to culture viable spirochete17. In about 85% of Lyme arthritis patients, B. burgdorferi DNA was detected in synovial fluid by polymerase chain reaction (PCR) testing

It would be great if this antibiotic could produce positive outcomes for PTLDS patients, but I wouldn't get too excited until we see some human studies. PTLDS (aka "chronic lyme") has a long history of promising treatments failing to produce results in patients.
"I didn't bother to listen, but I think it is wrong so there" is never really a useful discussion position.

The linked page describes a fairly specific set of needs that the claim is effectively true for, though only from the client's point of view.
Hmm, I think I own this book. rummages Indeed, here it is.
Exercise by club swinging in the 19th century
The second figure could have shown the client receiving the HTTP response to its request. Also, isn't HTTP/3 (QUIC) already supporting something like this?
Saw many similar request on twitter as well. Hopefully the two things ( Being Down and Phishing ) are coincidence.
"but for reasons that are unclear, the [traditional] antibiotics don't work for up to 20% of people with the tick-borne illness"

This is very exciting for a group of people that have felt forgotten and ignored by the medical industry
It was on purpose because TOML has not reached 1.0 yet and breaking people using a module in the stdlib for parsing TOML because TOML itself changed would be an absolute mess. Plus not a single packaging project said it was an issue to either depend on or vendor a TOML parser.

Once TOML hits 1.0 I plan to work on getting a TOML parser into Python's stdlib.

(disclaimer: I am one of the co-authors of PEP 518 that apparently handled things in way that was "a little absurd" .)
Or Linux Red Hat, iText Lib ( open sourced but under AGPL) etc. There is tons of open-source out there under commercial terms.
Browser automation isn't always strictly for testing... sometimes you need to perform a couple actions, to do a little scraping in order to facilitate an integration between two systems you don't control.

I really like puppeteer because it's generally much faster and more responsive than selenium and other alternatives I've used. Also, it's crazy easy to pass an async function, and it will serialize and run it on the client browser and return the result to you in your automation script.

If you're familiar with JS, it's so much closer to second nature in terms of the types of control you can acheive.
When I got Lyme as a teenager I was very lucky to notice a bulls-eye pattern (which not everyone gets) and quickly get treatment, with no complications after. I wonder if this new drug, or any future drugs, that work for the 20% of the people that doxycycline doesn't help, will also help people who figured out they had Lyme very late after being infected.
> This is the moron

You heard it here first folks. The guy who created the largest hedge fund in the world is a moron. You can't build a $160 billion hedge fund by being a moron. You have to be smart, ruthless and well connected. If you want to call him names, then call him greedy, sneaky, etc. Don't call him a moron because it's obviously not true.

> 'Cash is trash' just few weeks before market sellout...

There was also talk of a large short positions to guard against market sell offs.

https://www.cnbc.com/2019/11/22/bridgewater-associates-bets-...

https://www.bloomberg.com/news/articles/2020-03-16/bridgewat...

> and his alpha strategy is to sit out the losses

You do realize that his fund has performed much better than the market right? His "losses" are much smaller than the overall market "losses".

Also, his investment performance has nothing to do with his article about history/geopolitics/wealth/etc.
I always thought the "flightosome" picture was a great way that biologists can demonstrate just how complex biology is.[1]

When you see a biologist draw a system in biology, say, how a protein interacts with a cell membrane and then causes a change in expression within the nucleus, it can look relatively simple.

Well, it's about as simple as drawing how an airplane works. In this example, you have the "flightosome", which is made up of fuselage, wings, cockpit and landing gear. That's what transports passengers from one airport to another.

Simple right? Well even the landing gear component is complex and with biology, we have very little understanding of it at all.

[1]https://blogs.sciencemag.org/pipeline/archives/2017/02/01/th...
That looks cool.

I have two nanopressos which are also very good. One for home and one for work.

https://www.wacaco.com/pages/nanopresso
(Hint: Refactoring is usually an inefficient way to write a second system, with all of the downsides of the second system effect.)

Sounds like you are saying that refactoring is usually incompetently done to me.
Yes, but only for a specific set of circumstances (when you can live without reliable & timely delivery, and do not need any sort of response) and only from the PoV of the client.

The claim seems correct with those caveats, though is a bit "click baity" without them.
Do you have some organizational mechanisms in mind to prevent such an institution from eventually evolving gatekeeping and seniority (or to dislodge it from power if it does)?
To be blunt, as a long-time privacy advocate and former supporter of EFF, I'm pretty disillusioned by them. I think got compromised by FAANG.
I like how he formalized future state into propositional logic so you could reason about a system across time.
Peru, Panama limit men and women to alternate days out to stall virus
When not running my software biz, I make exercise machines which use flywheels for resistance. The difference compared to traditional weights is you get constant resistance at all angles throughout the entire range of movement.
Plus it allows many exercises in a compact package, and the resistance can be variable based on how hard you work.
It also includes an app + sensor (Electronic hardware is a complete PIA, but we got there in the end)
https://exerflysport.com
Aside from the fact that you're wrong, I think you need to take a break from the internet. You seem stressed.
On one hand women have innately different traits than men (but only good ones, except being physically stronger).

On the other, women and MTF trans are the same because it’s all about how you feel and any differences are because of the patriarchy.

Which is it? You can’t have it both ways.

Hopefully such junk science stops being published. If there is a way of communicating that’s better for both guys and girls, and some of both are capable of doing it, then it can be taught to both with most learning it.

Unless you’re going to claim most guys are simply incapable of reading social queues, or female social queues (excluding sexual attraction, where intent is often hidden).
Reducing tail latencies with automatic cooperative task yielding
I hate voicemail so much.

I wanted my phone number to "ring forever" if I didn't pick up, and here is the Twilio twiml bin that does that:

<?xml version="1.0" encoding="UTF-8"?>
<Response>
<Pause length="600"/>
<Hangup />
</Response>

OK, actually ring for 10 minutes, but that might as well be forever ...
It’s hard to disagree with what your saying, but analogies are fun.

I think the best analogy is DNA is a series of automated assembly lines. The workers, raw materials, and signals to turn sections on or off are separate. Each nucleotide station is called A, T, C, or G and adds a single element at a time to long chains which then get folded up into useful tools. DNA can also be used to manufacture either more stands of DNA or to do very simple repairs.

Alternatively, a stack of computer punch cards with a program on them. In that it’s a standard format for information transfer that is physically altered by the message it carries. Further, on it’s own nothing happens but connected to the right machinery it’s useful.
Twitter removes accounts linked to Egypt, Saudi Arabia, other regimes
Can someone tell the kids to use the actual website: http://www.meetgraham.com.au/ ?

This popsci article is dreck.
I don't think it's true that the existing pay per copy regime is actually forcing anybody to pay who doesn't want to. Everyone knows how to get media for free. The choice not to is already mostly an expression of voluntary donation.

As such, I think if every such work was instantly converted to a pay what you want model with a default asking price set, below which you're presented with a bunch of ads and an annoying email harvesting form or something, the majority of people would still pay the default price out of a combined desire to avoid annoying ads, avoid annoying forms, and to support the author.

Some would pay more if given the option to increase the amount paid in exchange for relatively trivial perks. Even I—defender of piracy extraordinaire—have voluntarily paid for luxury tiers for freemium content on numerous occasions.
Well obviously you don't need to maintain a background thread and a connection so you would be able to send out much more data using the same resources by offloading the TCP workload to the proxy.

If the service you are sending data to is unavailable, you wouldn't get any backpressure from it.

Think of a monitoring or log system where you might want to send out millions of datapoints but you can afford to lose some, in return you don't have to worry about the system not being reachable.
Anyone know how privacy-focused providers fare with this?
BMW uses blockchain to increase resource transparency
I agree! It’s a very interesting distributed system problem and honestly, I might end up doing some sketching tonight.

Right now it’s easy to know whom to tell about the coordination though: the Canadian government :).
I don't have any knowledge beyond what's in this article, but it appears that there is some evidence of Lyme bacteria surviving antibiotics, and the reason why this can occur:

"According to the recent study, azlocillin shows promise because it appears to be able to kill the two morphological forms of the Lyme bacteria -- the actively replicating spiral forms and the semi-dormant round-body forms.

Azlocillin also appears to kill drug-tolerant persisters very effectively. These protective persisters form when the bacteria are threatened with defensive immune system biochemicals or antibiotics. After the threat has passed, the bacteria can reemerge to cause active disease. Many researchers believe that doxycyline's inability to clear the persisters may account for the ongoing symptoms of some Lyme sufferers."
Show HN: Coronavirus in US Near Me
Have yet to learn Perl, but I've frequently not seen it preinstalled on systems, and additionally you sometimes need CPAN to be able to run scripts. awk might not be as powerful, but at least you know it's small, self-contained, and likely to be available in some form on most systems. That's part of its value I think... likely a consequence of not trying to do as much.
I don't think this solution is doing what you are looking for. To detect tables reliably in PDF you need some heavy-duty AI like https://www.pdftron.com/pdf-tools/pdf-table-extraction/
We put together a website to help you closely watch the Coronavirus cases near you in the United States and be informed.

Though there’s a lot of extremely well put together dashboards that have an array of data points and a ton of illustrations, many people especially the aged who are unfortunately the most vulnerable were looking for something a little less overwhelming, clean and simple that just puts out the numbers in perspective.

Get the details of COVID-19 cases in the 3 nearest infected counties near you alongside the numbers of the country and the world.

We're just a couple of programmers trying to do our bit to help keeping people informed on the latest coronavirus updates near their location. Just added a new feature to put in a zip code in the search box on popular demand for users to check stats where their loved ones are at!

Please share this with your friends and family if you think this could help someone be informed and vigilant.

PS: If you felt this was of some use to you or if in general you want to contribute to the WHO’s efforts in fighting this pandemic please consider donating to the COVID-19 Solidarity Response Fund for WHO by clicking on the Donate to WHO button at the very bottom of our website.

Stay Safe!

-Brogrammers
New Habits Time
Isn't that how SMTP has worked for decades?
Did the Gang of Four Thoroughly Explore “Pattern Space”?
I'll bite.

> Controlling someone else’s language and implying they are selfish for not changing is a lack of the social skills this framework purports to instill.

This is explicitly false. Please tell me where in the NVC book this is recommended. It never suggests criticizing someone else's language. In fact, quite the opposite - it puts the burden on you not to be upset at how people phrase things - even if they're shouting at you. Of course, if you are upset at the general communication approach with a coworker, it does give you a way to express it. It doesn't mandate it, though.

The NVC book is quite clear that there should be no judgment from you if the other party doesn't change. To the extent that part of NVC is defined that way. I mean, you can dislike it and disengage with the person (quit, divorce, etc). But blame the other person for not changing after asking them to? That's a clear no-no in the NVC book.

> You do not need to control someone’s language with a framework to enquire about their feelings.

You and the NVC author are in complete agreement.

> This NVC is fundamentally predatory on another’s mindset by controlling language under the guise of caregiving. It is an attempt to prime people for being heavily micromanaged in a few years by clogging up language with identifying feelings whilst real decisions are made by the nvc practitioners.

I must mirror a sentiment expressed in another comment. Has anyone who is critical of NVC over here actually read the book? The impression we who have are getting is that this thread is full of people who have little to no understanding of NVC and yet are quite critical of it.

None of what you wrote here is advocated for in the NVC book. There is an NVC cult out there who take things further, and while they annoy me, I have yet to hear anything like what you say from them either. It's certainly quite possible there are manipulative managers (i.e. assholes) at work who exploit it for their own gains, but a more likely prior is that people are entirely misinterpreting their efforts and in those people's world view such language is triggering.

I cannot alter a person's world view if he is not willing to discuss it. I do wonder which alternate universe these people are from where NVC is about labeling people for their refusal to change. It's like criticizing Gandhi's nonviolence movement for aiming to increase beheadings. It's just so antithetical to the concept that the criticism is so ... bizarre.

I stand by my comment above: It's totally OK with me if you don't like NVC. However, in a thread of over 100 comments, no one has pointed to an alternative that works when dealing with a wide variety of people. Sure - you can always filter people for "culture fit" and get a group where such language is not necessary. As your company grows in size, though, this becomes impossible.
Straightforward and amusing, yes. Honest? Well, they are paid to be "honest". Excuse while me while I go buy some hook and loop.
As someone who is a very active camper (pre-zombie-apocalypses summers) a human vaccination would be wonderful. When our kid was bitten, she had the same textbook bulls eye pattern so it was easy to see a clue. They use to have one, but it was pulled off the market.
Did a 6 person meet last night, all with video, and I was on firefox, worked fine.
vs code, webpack thumbs up emoji
I don't think this thread is about capacity. The comment I was replying to was about general service availability.
If only Vonnegut was still around to spin a tale about our current predicament.
Re: As I mentioned in my comment, JS frameworks by adopting a reactive model are getting closer to how desktops apps function. That has always been the goal

And they keep failing because they throw layers at the problem: chicken-wire is used to fix problems caused by the duct-tape on the prior layer, etc.

It's becoming pretty obvious that Yet-More-Layers only exacerbates the problem. It may get "solved" by having fewer browser choices, but then the evil of oligopolies will kick in and we'll be back to the IE-esque problems, one of the most hated browsers.

Re: I've developed VB and cross-platform stuff like Qt and wxWidgets, and that stuff is no easier than the stuff I'm building with JS every day. HTML templates + automatic reactive bindings via Vue and a Redux/Vuex 'backend' are very simple.

My experience is different, and I observe similar bottlenecks at various orgs. Those JS-centric frameworks are harder to trouble-shoot when things go wrong, and different browser brands/versions render them different and/or wrong. With the VB/Delphi-esque tools, things show up exactly on the screen where I tell them to go: there is no if, ands, and buts. They follow my exact commands like dutiful robots. The technology is MY slave instead of the other way around: Thou Shalt Go At X=37 and Y=200. My Will Be Done! (Cue thunder clap.) React/Vue et. al. often go, "Sorry Dave, I cannot do that, but I'll do it my way anyhow." (I recommend GUI's use vectors instead of pixels these days, by the way. They are potentially equivalent when needed.)

Further, the quirks in pre-web GUI tools were getting ironed out over time: they got better with age. The web seems to get messier with age because of the layer-to-fix-layer problem above.
Also recommend "Mao II" and "White Noise".
> how large your team is?

https://github.com/PDFTron/webviewer-ui/graphs/contributors
Great news! Let’s hope the FDA doesn’t hold this up for years.
Ask HN: What traits of senior engineers do you find most valuable?
I'm curious to know what non-senior engineers (juniors, mids, managers, CTOs etc) see as valuable traits in their senior engineers (and "above").

Some observations of the seniors on my team I really respect:

Patience in many forms. Patience to read docs and understand beyond surface level, to not jump to conclusions, to think about a problem abstractly before diving into implementation, etc

Strong communication. Whether translating a difficult problem to juniors, management, or non-technical folks. This also includes a significant amount of EQ (i.e. they're just nice people). Plays a role in mentoring and also arguing "up" for support on engineering priorities.

Willing to let go. This is a harder one to grasp - but basically being okay with scratching a project or area of code when it makes sense to, willing to set aside an opinion or lose an argument when it makes sense to, etc.

What else?
Well, Cloudflare's free tier costs money, but it was a good way to get people using the service, and now it's part of the ethos and culture people expect from Cloudflare.

By the time Akamai was being challenged by Cloudflare, they already had such a marketshare it probably wasn't worth racing to the bottom. Until Cloudflare is actually taking Akamai customers, I don't think they'll change.
The article mentions the same artist's Skywhale, so in case you haven't seen it majestically grace the skies above the Australian capital Canberra:

https://www.bbc.com/news/av/world-australia-51797186/skywhal...

https://en.wikipedia.org/wiki/The_Skywhale
Has anyone tested hydroxychloroquine against Lyme disease?
One thing to note is that even without this virus many economics still thought we would be heading into a recession this year. The underlying causes of that prediction would still exist (if not worsen) after we have hit the peak of this virus.

And the whole world needs to re-open. Our economy would still take a hit in the hypothetical event where our epidemic peaks without a vaccine or treatment (so if ~50% become infected with the live virus) yet China continues to deal with suppression efforts due to their order of magnitude larger population.
Yes, but note that they also admit that we only have some indirect suggestions that persistent infection is the cause of PTLDS symptoms:

> Many researchers believe that doxycyline's inability to clear the persisters may account for the ongoing symptoms of some Lyme sufferers

"Many researchers believe" is not the language you use when you have concrete evidence supporting the claim.

To date, no one has been able to culture these supposedly persistent bacteria from a PTLSD patient. Researchers are relying on indirect evidence, with no explanation for why the spirochetes can't be found in PTLSD patients.
I wouldn't be shy about betting the reason they haven't done this is because they don't want the ids to be longer/have a larger character set than they have to be, because they'd take longer/be more error prone to type/say out loud. Lowest possible friction: the reason for most of their flaws thus far.