skysight-inc/HackerNews huggingface dataset:
> Is it reasonable and the price worth paying?

It's a fair question, and it's one I considered before I called.

I don't know what happened in the end. Very possibly nothing. I had hoped that a uniformed police officer would stop by, talk to the partiers, mention that there was a complaint, also mention something about COVID-19, urge people to go home, and then depart.
I was looking at the Matrix clients yesterday, to set up a video chat room for elderly relatives. Everything seems just a bit too confusing or unpolished. I want something simple, functional and cross platform. At the moment I’m feeling Zoom with scheduled meeting times is probably the best bet. I’ll test this out, but does anyone have any other thoughts, or any non-proprietary recommendations?
>Note that there doesn't appear to be any evidence yet that chloroquine is effective in COVID-19 treatment. So far it has been studied only for other types of coronavirus.

Seriously? It seems like every few days a new study pops up here.

https://www.nature.com/articles/s41421-020-0156-0.pdf

https://www.mediterranee-infection.com/wp-content/uploads/20...

https://clinicaltrials.gov/ct2/show/NCT04307693

https://www.sciencedirect.com/science/article/pii/S092485792...

It seemed like there was no shortage of praise for this drug in the media, until president Trump mentioned it and then all the talking heads did a complete 180.
Do you suppose people who take prescription drugs without a doctor's supervision are letting emotions get in the way, or do you think they're acting rationally? And do you suppose it's possible their emotions are influenced by the glittering generalities they heard, even though your emotions are not so influenced?
There was a lot of resistance until Elon & Trump mentioned it.

The negative reaction to the French study has been pretty intense.
I’ve actually considered switching away from the default mail client partially for this reason. With multiple accounts it’s gotten pretty difficult to see which account received the email, moving multiple screens to see it. And often Apple Mail will get an email to one address but when you hit respond it will try to reply with a different email address. That last one has led to a couple embarrassing moments trying to email clients in a hurry and accidentally replying from my personal account.

It certainly doesn’t work like magic.
Chloroquine was banned years ago in my country due to its toxic effects (was making kids deaf amongst other things).

Are its downsides worth the upsides when used as a COVID-19 treatment?
> like most videoconferencing

Well, if there's only 2, maybe 3 of you – anything beyond that is going to use a server to host the call for reliability.
It's funny, I looked out my airplane's window earlier and saw a FedEx labeled package getting loaded with luggage. I thought it was curious and came upon this article around 15 minutes later. Makes sense now.
A 2009 paper shows that you can tell blank pages apart from one another by examining them closely under a scanner: https://citp.princeton.edu/our-work/paper/

So not only is there so much texture there, but even a single manufacturer's individual blank pages differ dramatically because of physical wood fibers within the page.
Actually they rarely translate.

Chloroquine is a particularly funny example because they have already tried it as an antiviral drug several times without any efficacy.
Bash should be recognized as the tech equivalent of asbestos.
This quote does not literally say or imply one should self medicate. This quote in context appears to misrepresent the lethal dosage of the medication.
Fair, that link points out the Kernel hosts some sandboxes directly. I had assumed they mostly had to be opt-in at the application level (opt-out in the case of the UWP platform), given the name, and those Panes are open third-party extension points and it does seem like sandboxes should apply to anything running in them as well, so it seems a fair assumption to believe that is where they were applied.
I'm sorry that you or someone you know ended up not receiving an offer. Twitter is indeed still hiring. While admittedly Twitter does hold a high bar for hiring, we put a lot of effort into making sure that our assessments are done fairly, based on the best we can tell about the candidate's current level of technical and nontechnical skills relevant to the role. Sometimes this may mean teams continue the interview process further with candidates who seem promising but risky. When that does happen, it's not because of a number of applicants metric (this isn't a metric I've heard about internally), it's because we want to give people a fair chance. Admittedly, there is a careful balance to be made between giving people the time to demonstrate how they shine and wasting candidates' time because it's not the right role. There's also cases where someone interviews for one role, doesn't have the right skill set there, is referred to a different role, and then does very well and is hired. I don't think any interview process at any company is perfect, but we are always trying to improve.

I'd also like to add that one of the ways we offer a level playing field for candidates is by strongly supporting remote work (which started long before COVID-19). We have multiple offices both within and outside of the United States, and many people who work from home in jurisdictions where we have the ability to employ people. Unlike the team in the grandparent comment, many Twitter engineering teams are currently particularly looking to hire outside of San Francisco (both to increase our geographic diversity and to reach the best candidates wherever they may be).

So if you're looking for something new, like Twitter, and see a role on https://careers.twitter.com that you honestly feel is a good fit, please apply!
I was (falsely it seems) under the impression that Hydroxychloroquine [0] was being considered as a treatment option instead of regular Chloroquine, which appears to be less safe.

[0] https://www.nature.com/articles/s41421-020-0156-0
I think that this happens if you change the send-with account for a given account (so if account X sends via the Y server, it will have Y's return address). Other than that, I've never had the return address for a reply have anything other than the address of the account it was sent to.
Location:Colorado

Remote:

Willing to relocate: Yes, thanks!

Technologies: Electrical Engineer EE A.a.s

Résumé/CV: Send email

Email: rweekscap@gmail.com

Grateful Day!
> "I got a counterfeit product on Amazon, therefore I won't trust AWS".

This is actually a good argument. I can easily imagine that this could become a problem for Amazon in the future.
There is absolutely evidence of effectiveness against COVID-19 in humans from China, South Korea & France.
Project Seems the Future of Language Learning
Packaging an app in Docker is work up front and then ongoing overhead to manage. If something I write is only going to ever run on one server, it may be easier for me just to install it on the base system, not in a container.
Related: I explored Facebook's physical network in https://nullset.xyz/2020/02/28/exploring-facebooks-network/.
My Macbook Air recently died and in a hurry (lockdown is tomorrow) I've bought a refurbished Dell Latitude which is a little bit more powerful (last week). Surprised that Desktop Ubuntu 19.10 still does not compress RAM (but easy fixable) although Windows and Mac do that by default. It is super necessary with Chrome (Apps).
Biggest downsite is that programs/sites like Slack, conferences or Youtube videos are not as smooth as on Mac although I have more horsepower now in sense of CPU.
I have the big feeling that the CPU scheduler on the Mac&Windows does a way better job than Linux on desktop environments. E.g. hitting the 100% CPU area (only with Chrome somehow) I can hear the crackling sounds on conferencing calls.
Who are you arguing with that you thinks we shouldn't be doing clinical trials? Why do you think these things are "insane"?
No more DSLs for deployment/config management tasks please. Too many already.
Covid-19: A Cocktail of HIV, Malarial and Swine Flu Medicines Cures 3 in India
> ... “The team of doctors under the leadership of Dr Sudhir Bhandari, Principal of SMS Medical College held consultations with the ICMR and tried a combination medicines given for malaria, swine flu (Tamiflu) along with drugs for HIV and it worked well. All three persons including the Italians were cured this way,” said Rohit Kumar Singh, additional chief secretary, health of Rajasthan government.

Source: https://www.nationalheraldindia.com/india/three-coronavirus-afflicted-patients-recover-due-to-innovative-treatment-by-doctors-at-jaipur-govt-hospital

> ... “After much thought, we decided to work on the antiretroviral therapy after getting approval from the Indian Council of Medical Research in Delhi. Within five-six days using the combination of medicines, we first cured the Italian tourist, who is 69 and then his wife who is 70. The magic medicine worked in the third case when we cured the eighty-five-year-old person of Jaipur who had contracted the disease in Dubai” said Dr Sudhir Bhandari.

> “But to begin with, the patients were given medicines that are given to the swine flu patients and thereafter drugs given to HIV patients were given. Luckily the cocktail worked wonders and the doctors saw sudden improvement in the health of the patients.” Said Rohit K Singh.

> The three persons who tested positive were administered a combination of 200mg Lopinavir and 50 mg of Ritonavir twice a day besides Oseltamivir and Chloroquine that are given to the swine flu and malaria patients.

> However, the doctors at the SMS Hospital warned that this was only an emergency treatment and the HIV medicines were used only as an emergency measure that could help in regaining normalcy.

Source: https://www.nationalheraldindia.com/india/covid-19-magic-medicine-of-jaipurs-hospital-cures-3-patients-draws-attention-in-medical-world
Maybe they shouldn't, but isn't that kind of the whole problem with overdose? People take a higher dose than they should?

Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year.Data from the U.S. Acute Liver Failure Study Group registry of more than 700 patients with acute liver failure across the United States implicates acetaminophen poisoning in nearly 50% of all acute liver failure in this country. Available in many single or combination products, acetaminophen produces more than 1 billion US dollars in annual sales for Tylenol products alone. It is heavily marketed for its safety compared to nonsteroidal analgesics. By enabling self-diagnosis and treatment of minor aches and pains, its benefits are said by the Food and Drug Administration to outweigh its risks. It still must be asked: Is this amount of injury and death really acceptable for an over-the-counter pain reliever?

https://www.ncbi.nlm.nih.gov/pubmed/15239078
Ackman goes all in, all longs, no shorts
Those without antibodies can get plasma with antibodies.

https://www.statnews.com/2020/03/05/how-blood-plasma-from-re...
Like this?

“I like this stuff. I really get it. [...] People are really surprised I understand this stuff. Every one of these doctors said, ‘How do you know so much about this?’ Maybe I have a natural ability.”

“Anybody who wants a test will get a test, that’s the bottom line. [...] The tests are all perfect, like the letter was perfect, the transcription was perfect, right? This was not as perfect as that, but pretty good.”
Yeah, which only establishes that the baseline understanding the common person has when taking drugs is to take the recommended dose. And nowhere was Trump saying "go crazy".
Looks like the aquarium version is likely not the same as the pharmaceutical one...

>Keep in mind if you decide to use the tablets, there are some inactive ingredients, which you may have to deal with, e.g., Camauba Wax, Colloidal Silicon Dioxide, Dibasic Calcium Phosphate, Hydroxypropyl Methylcellulose, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate 80, Pregelatinized Starch, Sodium Starch Glycolate, Stearic Acid, and Titanium Dioxide. And as mentioned earlier in this chapter there are occasions where some medicines are not in their pure form (100% pure), i.e., mixed with a substance called a 'carrier,' which should be noted on its label.

https://www.nano-reef.com/forums/topic/406204-chloroquine-ph...
Ferrum Health | REMOTE | Full Time | Senior Backend Engineer | https://ferrumhealth.com

Medical errors are the third leading cause of death in the US, and Ferrum builds AI-powered monitoring systems to help health systems detect and address mistakes before they affect patient care.

Ferrum is a fully remote and distributed company focused around the US and European timezones. Since launching its first offering for lung cancer errors two years ago, Ferrum now covers over 10 million patients at nine health systems around the world, including the US. The company is backed by multiple top-tier venture capital firms and is led by an experienced digital health founding team that includes industry leaders in enterprise healthcare, machine learning, and edge infrastructure security.

We are looking for Senior Backend Engineers with a strong understanding of distributed systems and Linux internals to help build out infrastructure that is deployed to healthcare systems. The backend stack consists of Go and containerized environments with deployments in cloud and bare-metal environments. You would be joining an engineering team of nine people who have proven track records delivering solutions in the networking, storage, and machine learning spaces.

Our ideal candidates has proven technical skills in addition to a passion for improving the quality of healthcare.

To apply, send an email to jobs@ferrumhealth.com.
Where are you getting the 5% from? You're just adding the 5% on and on prior to "What if's" that don't sound plausible to me. Although if you did quote experts there I would like to know, that could change my view. To my current knowledge it is more and more looking like its fatality rate is sitting around 1%. People, especially older ones, die, we often supress that thought in the western culture. And many die, everyday. If the economy crashes many more will die most certainly.
We have a lot of experience working with Jitsi Meet, if anyone has questions integrating Jitsi, free to send me an email john@taskade.com. Happy to help!
I'd rather more DSLs than more things with complex logic encoded into YAML.
I switched back in 2008 as the economy was headed down. I did not notice, just felt I needed to get out. New company laid me off after 11 months, as the market hit bottom. Company struggled with cash flow issues. To be fair, the new VP hated the director and manager who hired me. Director was let go after I was there 6 months. My manager and all her employees were let go when I was let go.

Had I stayed with the prior company, not sure what would have happened.
Sorry for what is probably a silly question, but are you saying someone can be infected through an open window?
Valora Digital | Head of Engineering | Full-time | Zurich, Switzerland | ONSITE

Valora Digital is the newly founded digital unit of Valora, a European retailer with 2700 stores across 5 countries. We are tackling interesting challenges in areas such as Autonomous Stores (think Amazon Go), Ecommerce & Delivery, Loyalty, Payments and Process Improvement. For this purpose we are building up a development team from the ground up. You will be one of the first engineers and will have a big part in shaping the culture as well as choosing our stack. We are looking to bring the startup ethos to the corporate world and get to combine the best of both worlds: ample funding, a huge customer base to deploy to and lots of freedom. I'm the head of this new unit and was previously a founder, CTO and CEO.

We are looking for a Head of Engineering interested in getting their hands dirty in code on a daily basis but also able to transition and grow the organization into something much bigger.

Please apply here https://recruitingapp-2538.umantis.com/Vacancies/9277/Descri... or get in touch directly at michael.wirth@valora.com
I view it as:

Explainable models = statistical models (regression / multilevel models).

Black box models = machine learning (tree based models).

AI = black box models for computer vision / NLP.
Anyone running around actively exploiting a zero-day Windows font parsing exploit likely also has a sandbox escape exploit too.
You got that wrong. Nitric oxide is a vasodilator, it relaxes smooth muscles in the blood vessels and lungs to increase blood and air flow. It has nothing to do with fighting coronavirus or any other kind of virus, it's supportive treatment so that the patient doesn't suffocate.
This is the first time I've seen an article on the front page of Hacker News that has the phrase “here are” in the title.

I’ve noticed over the last few years this trend to add a superfluous “here is” or “here are” to a headline. Doing so add absolutely zero information, e.g., from the top three current Duck Duck Go search results for “here are”:

1. “Here Are All the Major Concerts Canceled Due to Coronavirus” – could just be “All the Major Concerts Canceled Due to Coronavirus”

2. “Coronavirus: Here Are 10 Misconceptions Being Spread” – this listicle could simply be titled “Coronavirus: 10 Misconceptions Being Spread” or “10 Coronavirus Misconceptions Being Spread”

3. “Have Children? Here Are 3 Tax Credits You Need to Know” – this listicle could be “Have Children? 3 Tax Credits You Need to Know”

In two of the above cases, it’s also not just the headline but the text body also. I get the psychology behind listicles (and other clickbait phrases such as ”you need to know”) but I don’t understand the rationale for inserting these two wholly superfluous words that neither inform the reader nor embellish the prose.

It’s had the opposite effect on me and I now have an internal heuristic of associating this practice with low quality information and I rarely – if ever – click on such links. Going by the comments on this article, it seems I was right in this case but surely, that’s the opposite of what the publishers intend.
In the movie Contagion (2011) there's an influencer promoting an untested medicine during a global pandemic. It was quite scary and upsetting and all too real.

But now we have the president of the United States recommending you to make your own drug cocktail during a global pandemic. If someone had written that in the script it would've been thrown out as too unreal.
What part of stay home does Amazon not understand? People should stay home; the economy's crashed anyway, what does it matter if your stupid boss at your greedy company fires you?
WeWork directors prepare to take on SoftBank if it abandons rescue deal
> complex logic encoded into YAML

This should stop too.
Please let me and the CDC know of these well-conducted trials of chloroquine for COVID.

I take it you are not familiar with epidemiology, clinical evaluation of drug efficacy, or medical statistics. That’s fine! No one is saying you need to be. But you shouldn’t be extremely confident of your conclusions when experts are telling you that you’re wrong.

The French chloroquine+azithromycin trial was terrible and no one in the medical world believes it. There’s a reason no respectable journal would publish it. SIX of the people in the C+A arm died and were removed from the analysis, which is absurd. The outcome was viral titers, which were different for different arms. Just maddening.
compared to a name that invokes the church of the subgenius, or its competitor that invokes the alternative: discordianism?

jitsi seems quite tame compared to both of those.
I am not really sure why you think I was listing only OTC drugs. Chloroquine does require a prescription in the US, so comparison with other prescription drugs seems entirely reasonable to me.

Two points on the topic of OTC drugs in the US:

1. Unfortunately you can buy Lithium as a supplement in the US. I have seen bottles of it for sale on Amazon.

2. Having seen enough accidental (not to mention intentional) overdoses from Acetaminophen, I wouldn't be so fast to act like the therapeutic index is wide enough to be treated as "safe". Anything with a narrow therapeutic window needs to be weighed carefully before use. I hope your take away from my comment wasn't that I think chloroquine is "safe": merely that there are a lot of drugs with narrow windows, and there are trade-offs associated with their use. I included that paper because it discusses this very explicitly.
Iodine is approved for treating exposure to radiation. That doesn't mean it's OK to start drinking from a bottle of industrial-use iodine that isn't made for human consumption.
Pretty well. I am enjoying working from home and while I am very bored stuck at home, it is weirdly relaxing.

I am sure I will eventually get infected but I am not too worried. I am young and somewhat healthy, and I am never in contact with anyone old or particularly at risk.

The thing I am most afraid of is the impending economic depression.
Build applications based on a marketplace of customizable components
Ask HN: Career Advice for CS Researchers During an Economic Downturn
I work for a computer science research lab in Silicon Valley. My job is safe for now. However, I'm concerned about the effects that coronavirus will have on the global economy and its effects on my employment later this year.

I've noticed two trends regarding industrial computer science research:
1. There seems to be few companies investing in computer science research, and even fewer of them run research labs that are less focused on immediate productization and are more focused on medium- and long-term projects. The only lab I could think of that is run like the 1970's-era Bell Labs or Xerox PARC is Microsoft Research, and even there I've heard that the lab has more pressure to commercialize their results than in the past, though I may be wrong.
2. Companies typically expand their research labs whenever they are doing well, and they typically cut back on research or even abandon research entirely whenever they are not doing well (e.g., the shutdown of Apple's Advanced Technology Group in 1997).

I understand that in today's world people should not expect to stay with one company for their entire careers, and that people should be prepared to possibly change careers during their working years. I'm wondering what is some good advice for people outside of the tenure-track to stay involved in the research community even in the face of downturns. I have been laid off from a similar job a few years ago and it took a long time to find another job in a research environment.
Just came across this on HN too: https://www.8x8.vc
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Yeah, but can we quarantine war? People are dying out there, and we can't even get to people to stop going out to the bars! And you want to stop wars?
Note that a study in the New England Journal of Medicine on Wednesday stated that the treatment (with only the antiretrovirals, I presume) is not effective

Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2001282

A drug company whose medicine was used in the trial, and was deemed ineffective, contests that the medication was used too late.

Source: AbbVie's HIV drug Kaletra stumbles in COVID-19 trial, but one analyst begs to differ - https://www.fiercepharma.com/pharma-asia/does-abbvie-s-hiv-d...