skysight-inc/HackerNews huggingface dataset:
Any thoughts on why they’d be using Rust rather than Swift for this work?
https://www.sanitainformazione.it/salute/scovare-i-positivi-...

In English:

https://mobile.twitter.com/andreamatranga/status/12397748625...

> According to Crisanti, the director of the virology lab of U Padua, as little as 10% of #COVID2019 carriers show any symptoms at all. He sampled repeatedly the entire 3k+ population of Vo ', one of the initial clusters.

https://grapevine.is/news/2020/03/15/first-results-of-genera...

> 700 have been tested. Kári says that about half of those who tested positive have shown no symptoms, and the other half show symptoms have having a regular cold.

https://www.repubblica.it/salute/medicina-e-ricerca/2020/03/...

> "The vast majority of people infected with Covid-19, between 50 and 75%, are completely asymptomatic but represent a formidable source of contagion". The Professor of Clinical Immunology of the University of Florence Sergio Romagnani writes
I don't think any of the top answers are good at all. I suspect part of the reason is how poorly we understand muscle fatigue.

Many answers talk about lactate and how it builds up in muscles but not the heart. However they don't say anything about how lactate is related to fatigue.

A lot of the answers talk about the high mitochondria concentration in the heart. This allows it to use more oxygen and produce more ATP. That's fine, but again, what is the connection between mitochondria and fatigue?

One example to show these answers are inadequate: You can walk or jog at an easy effort for a long time and eventually your muscles will get tired and sore, without ever going anaerobic or lactic -- i.e. without your leg muscles ever needing more energy than your mitochondria can provide or ever producing more lactic acid than your bloodstream can clear away immediately.

So mitochondria and lactic acid can't be the full story.

I don't know the true answer and I'm not a biologist, but I suspect the heart has evolved to never be the weakest link. Maybe exercise always strengthens the heart at a higher rate than the other muscles. Or maybe part of the answer is that we don't have nerves to feel soreness/tiredness in the heart? (I have seen research that the heart does experience temporary damage from e.g. marathons, so it does get tired in some sense. Of course then it gets stronger.)
10yr old, same topic

https://www.youtube.com/watch?v=Q5paWn7bFg4
I'm basing it off of this comment:

https://news.ycombinator.com/item?id=22643333

And this follow-up comment sort of agrees with my inference -- at least the first part of my inference:

https://news.ycombinator.com/item?id=22644577

Edit: I will add that I am also, no doubt, basing it off of background knowledge about cell function. For example, mitochondria change and develop greater capacity to process X if you consume a lot of it, which is part of the addiction process and part of why withdrawal is a thing. If you consume a lot of, say, alcohol, you need to ramp down gradually so that the body can make changes at the cellular level to adjust to the lesser amount of alcohol and this is part of why cold turkey is so very hard and it is generally recommended that you taper off.

I used to ask smart people with PhDs and the like a lot of questions about cell function and read what I could get my hands on that could be followed by a lay person because I have a genetic disorder that impacts cell function.
Not unless having vast amounts of mitochondria is a competitive survival/reproductive advantage favoring natural selection of individuals in their environments
Fair enough, I should have said, ”In some areas”. A little snippet from the CDC I have posted a bunch that I found useful -

”Pandemics begin with an investigation phase, followed by recognition, initiation, and acceleration phases. The peak of illnesses occurs at the end of the acceleration phase, which is followed by a deceleration phase, during which there is a decrease in illnesses. Different countries can be in different phases of the pandemic at any point in time and different parts of the same country can also be in different phases of a pandemic.”

So, we know not all the hospitals are experiencing the same levels at the same time. A big reason I wish we were more precisely targeting shutdowns and quarantines.

It doesn’t make sense to throw these blanket executive orders over entire states. As we can see from the slides, the economic consequence are dire. Why not target the cities entering acceleration only?

In the meantime, start building drive thru testing. Distribute thermometers. Practice social distancing & aggressive sanitation, but not destroy out national security in the process.

But this part,

”All of Italy’s victims under 40 have been males with serious existing medical conditions”

Sure it’s early, but even in Italy, in one of the worst places in the world for the virus right now, that information should be very illuminating to us I think.
I wonder if the hit from freezing debt is less than the gain from having the vast majority of the working economy get a de facto 2x raise. Lots of people are rent burdened which only hurts an economy driven by consumer spending.
> the ones with important jobs are often paid the least.

that's the wrong way to think about it, and also a misunderstanding of economics.

If a teacher is paid the way a CEO is paid, there won't be enough money for very many teachers. You'd find it hard to afford a teacher for your kids, let alone free education.

A doctor, back in the middle ages, is only affordable to the nobility. These days, doctors are still quite highly paid (too high imho), and that is one reason why medical services are expensive.

Imagine if you associate the "importance" of a resource with its price. Water would cost more than diamonds and gold! Water is needed for sustaining life - you die without it. Therefore, in theory, it's so important that you end up paying infinity amount of money to have it, under your system!

The fact that we have water so cheap (literally 0.000001 cent per cup), is a good outcome. Everybody can afford water.
For a vast amount of human history food has been much harder to obtain and less calorie-dense than it is today, so evolution has optimized for energy efficiency rather than raw power.
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not only energy expensive but free radicals do genetic damage, and a this requires the second budget for a set of enzymes to counteract the damages and scrub out FR's
Right, great consistency in customer experience from companies like Comcast, Google, United Airlines, Bank of America, Walmart, Best Buy, etc.
Crypto Adoption Takes a Step Back Amid Coronavirus Outbreak
Anybody: “what’s your primary OS?”

Me: “Emacs.” /s

Wanna-be hard-core Emacs user here. Tried this out today, worked beautifully. A few glitches (I’ll send a bug report if I can reproduce) but splendid by and large.

There is something to be said for using Emacs an application platform. It is the ultimate IDE, and a self-contained marvel of hackage that somehow works.

Thanks for posting this!
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software
I'm an Android user and don't see myself moving to entire apple ecosystem. So if I had a MacOS I don't directly see many benefits. (correct me if I'm wrong)
http://www.euromomo.eu/

The all-cause mortality rate in Europe has been dropping in the past few weeks and is now well below normal levels. To me this looks like people have been overdoing the whole stay indoors and avoid any sort of risky behavior.
My point was that a 1-month or even 3-month lockdown doesn't stop exponential growth permanently, it just pauses it. A permanent lockdown would stop it, but it's obviously not sustainable.

And I wasn't trying to dispute your claim that the "best endgame" is the goal, merely clarify it - and also point out that even then, we will still see our healthcare overwhelmed, and a lot of people will still die because they will be rationed out of the system. People who wouldn't have died if we locked things down when containment was still realistic - so I consider them all preventable deaths that we have failed to prevent as a society.

To be absolutely clear: a lockdown is still our best bet, and the lives it'll save are worth it.
Thanks for the tips. I'll fix those issues.
Nothing. The problem is, by and large they don’t. D is a fantastic project and an important step forward, but Rust has won the mind share game.

https://insights.stackoverflow.com/survey/2019
Sony has owned Lemmings since the early 90s. They have actually released Lemmings games somewhat regularly for their consoles. Most recently, in 2018, they did a version for iOS and Android: https://apps.apple.com/us/app/lemmings-the-puzzle-adventure/...

Unfortunately it’s a typical free-to-play mobile game where you buy gold to keep playing.
> rent should be free

What about property maintenance?
Because all known multicellular organisms, with the exception of a few (<10 out of millions) microscopic species, use the electron transport chain to produce ATP and the animals whose primary organ responsible for supplying the entire body's metabolism suddenly stopped all died on the spot.

Now, how those animals survived is a much more interesting question.
There have apparently been good effects related to pollution and therefore climate change.

Like you say, these effects don't counter the immense human suffering happening.
I mean ... none? This thing has been a disaster of information. The John Hopkins map was made by engineers and it's arcgis in a damn iframe. It has terrible visualizations. No one seems to remotely be displaying any of the data in ways that are helpful. No one knows the actual infected to confirmed rate or even has a decent guess.

We're told ~70% of people won't need to be hospitalized .. we're also seeing hospitals overrun in Italy with perfectly healthy people in their 40s dying.

We're in a wash of really bad information and panic and we have people criticizing those who are trying not to panic. And none of us are really talking to each other, because we can't.

It's a 1984 style cluster fuck.
It seems short-sighted to have focused all efforts on safety engineering, which is inherently boring to investors regardless of whether it’s the correct approach (I believe there’s a strong argument that it is).

Unfortunately it seems like they found this out the hard way. Would be genuinely interested to understand why they didn’t do some split, say 60/40, safety/flashy new AI features. If the goal was to extend runway, this may have just done the trick. Or perhaps the headwinds are just too strong and they would’ve crumbled around 2021/2022 anyway like they predict most others will.

Wish them the best, not easy to go down when you’ve given it your all, especially in this environment.
Do chimps/apes have a greater muscular power-density than humans?
Here is an open-source 3D mask model:

https://www.3dnatives.com/en/mask-against-covid-19-180320205...
I answered this question in the discussion at https://news.ycombinator.com/item?id=22643381.
Why would the US want to turn victory into defeat?
You can, but the passcode for my iPhone is super long. Easier to just take the mask off for a second.
Yes, it would. King County WA (where I live) has around 2 million people. Assuming half of that get infected and 15% require hospitalization. That's 150k people flooding the hospitals. That is way WAY above what the hospitals can handle. And I'm not only talking about beds and ventilators. Think about road accidents or coronaries which happen at a known steady pace when it's business as usual. These cases require ambulances and quick response times which cannot be met anymore because the system is overloaded with covid-19 patients. What do you do? Turn the 60+ patients away?
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Yeah that's a fair point.

Another point I forget to mention is mask wearing which certainly is cultural. In Australia and much of the West it's considered not normal whereas no one thinks twice in Asia.

I've seen Australians say they wouldn't wear one even if sick and we've had incidents of people abusing perfectly healthy mask wearers in Sydney demanding they self quarantine.

These attitudes within a society have pretty clear outcomes for anything contagious.
Sure, we’ve made huge progress, and are still making huge progress, but it’s just not enough.
Another part of the answer is that fatigue is largely in our heads. Your body wants you to minimize energy spending, probably because in cavemen days food was so hard to obtain. You will feel tired long before you hit real physical limits. If you've ever taken amphetamines, it becomes obvious. Suddenly, you can spend all night dancing more energetically than you ever did without feeling tired, work longer than ever, etc. Not suggesting that this is in any way sustainable long-term, it isn't, but for me, it really highlighted how my body is physically able to go several times beyond the point where I feel tired and uncomfortable. It's just that some core instincts really don't want me to spend energy liberally.
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I don't know how you do your financial planning, but when I invest my money, I expect to see a return. I expect most folks do. Everything else falls out of that.
Canceling things
The azithromycin was given to some of the patients with viral pneumonia as there is a chance of reinfection with bacterial pneumonia. Astonishing and unexpectedly, the covid19 virus was completely wiped out in all the HCQ+azithromycin patients but only in a bit over half the HCQ alone patients. So just as an antiparasite drug surprisingly once was found to also work as an antiviral, azithromycin has unexpectedly been found to have some sort of a complementary amplifying or catalyzing effect with the hydrochloroquine. Of unknown mechanism and no doubt this will be explored in great detail in future research. For now it's known that putting the two together looks to be a good thing to do.
He would have lost his sons college thition then. Mitochondrial _inhibition_ is actually more correlated with longevity than the other way around.

If more mitochondria meant more efficient working muscle tissue, then that's what we would have evolved, there's always a compromise. Are you sure you can keep the same power output for a given mass and volume of muscle if you keep increasing mitochondrial numbers? Even the reddit answer clearly says that the heart muscle is rate limited by oxygenation (they have more mitochondria but are also highly vascularized to power the mitochondria). More mitochondria===more power doesn't mean it's better for us, physiology is rarely that simple.
Same, loaded up disney+ and it caused the whole UI to lock up and eventually crash. Super weird.
> French Revolution?

Didn't even last a decade until they got themselves an emperor.

> Arguably the Russian Revolution if you accept the USSR as a step up from feudalism.

Considering that the USSR killed orders of magnitude more of its own people than feudalism under the Czars ever did, I'm going to vote "no" on this one.
Thanks for the tip. I've considered the original shipment of 200EUR (plus 60EUR shipping) a loss, and I've just ordered another 150GBP of lenses; with any luck those will reach me within a month. This whole mess is so unbelievably wasteful.

If they're not going to do away with them entirely, laws and regulations should have a "suspend_in_disaster" flag when passed, the same way they have giant carve-outs for bans of things for human beings that don't apply at all to the police.
Ugliest keyboard ever?
You don't need to go full luddite on this. I have a 10yo Prius, which obviously for the hybrid system has a pretty complicated computer system. I've only had to have a few software updates which were done when servicing. The infotainment system is garbage compared to modern cars - it has Bluetooth though, so it does what I need it to do - but the drive system works as well as it did when I bought it.

The only issue I've had is when the 12v battery needed replacing and it was -20c outside, half of the dash (the trip computer, efficiency and seatbelt display) wasn't working.

I'm not exactly sure what new features they could add with just a software change.
Free as in radicals, not free as in beer.
Is there any page that describes how to actually get VPN work end to end with tailscale?

I am a newbie and would like to understand.
> I was a poor kid who got into UC Berkeley based largely on my SAT II scores.

So did the admissions officer mail you a letter that said “congrats! Based largely on your SAT II scores, you’ve gotten in!”

If not, what enables you to discount the possibility that you still would have gotten in without the subject test?
> Why not target the cities entering acceleration only?

Because the long incubation period and the lack of sufficient testing makes it impossible to know which cities are infected early on.

And, to put more bluntly, because we have two models to look at and choose from: the Chinese one, with harsh containment measures that were very effective (if you believe their numbers) and the Italian one, with moderate containment measures and a lack of sense of urgency from the populace, which resulted in a downward spiral with more deaths than China despite having only ~58% the number of cases.

> I should have said, ”In some areas”.

And no, you shouldn't have said that, you should just wait another week.
Yes; Gopher is still in use, although not much. You could probably find a few Gopher servers still in use (I have found a few). I have my own Gopher server, too.
Is there an open source version of this?
As others pointed out, an increased output would not be sustainable long term within the normal body. The physiology behind action potential[1] and refractory period[2] explains how they compliment each other to make sure our system function properly and effective.

1:https://en.wikipedia.org/wiki/Action_potential

2:https://en.wikipedia.org/wiki/Refractory_period_(physiology)
Europe runs on 230V 50Hz.
Help stop the spread of Covid-19 with contact tracing – Singapore gov app
I don't think you can really get around linked lists having bad cache locality even if they're intrusive. The point of arrays usually being faster is that they're much more cache friendly, and fitting data in cache and avoiding branch mispredictions is usually much more important than o(1) insert/delete.
Works as well
> There's nothing wrong with people that are living together going for a walk together, it won't particularly increase their exposure.

And it might help to keep them from going stir crazy from being cooped up inside too long...
Honestly, what do you think is going to happen to these people if the economy totally shuts down? it's going to be easy to have a chronic & serious health condition? The same?

My feeling is that I'd rather be chronically sick in a good economy than in a depression. What happens when medicine becomes unavailable due to supply chains being cut off?
I hate to spread a wacky idea, but I ran across something on Facebook the other day that I initially wanted to disprove but then started to seem plausible. The general consensus is that the heart is a pump and generally the sole driver of circulation in mammals. There is an alternative theory, which seems easy to disprove, that the heart is more of a regulator and operates more like a hydraulic ram. I can post more links later. Curious if anyone has heard of that and if there is a rebuttal to the idea.

Edit: The paper I was thinking of, if anyone is interested, is here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215277/

Edit #2, from the paper: "Gladwin et al. estimated that 25% to 30% of basal human blood flow can be attributed to red blood cell-induced production of nitric oxide by vascular endothelium."
30 year old computers are worth some money.
The one credible source among your links talks about surveying a population and seeing of those testing positive for Covid are asymptomatic or have cold symptoms.

But this finding is not extrapolated to mean that the vast majority won't require hospitalization. There's a reason. When the virus is growing exponentially, most people have just gotten the virus and haven't gone the 2-3 weeks typical for becoming so sick that you require hospitalization. Exponential growth means 3-week old cases are rare. A weekly doubling time 1/16 of the cases of the cases are three weeks old. If 1/5 of those cases require hospitalization eventually, you will wind-up with only 1/80 of those cases seeming to require hospitalization if you're just taking a survey.

Some of my references are extrapolating things (correctly) but others are citing recognized authorities. Your entire argument is basically incorrect extrapolation based on not taking into account exponential growth.

This article widely read article summarizes the quandary we're in and how to extrapolate the current data.

https://medium.com/@tomaspueyo/coronavirus-act-today-or-peop...

People need to read it and stop with the destructive misinformation.

https://medium.com/@tomaspueyo/coronavirus-act-today-or-peop...
In Alberta too. No surprise really. Both Quebec and Alberta (also Ontario) have LOTS [1] of political influence from traditional engineering companies.

You know, not that long ago in Alberta, you could use "Software Engineer" without a P.Eng license.

Then the engineering society (APEGA) sued someone (Raymond Merhej) who did that [2]. But Raymond won in the courts.

So APEGA appealed. But Raymond won the appeal in the courts too.

So APEGA lobbied the Alberta Government to change the laws.

And APEGA won.

[1] An example from Quebec: SNC-Lavalin affair (https://en.wikipedia.org/wiki/SNC-Lavalin_affair ).

And from Alberta: "Kenney’s United Conservatives were elected last April on a promise to focus on oil and gas and bring jobs back to Alberta by reducing the corporate income tax rate and red tape" (Alberta government files red ink budget with focus on oil and gas, https://canada.constructconnect.com/joc/news/government/2020... )

[2] https://www.itbusiness.ca/news/it-industry-wins-round-in-eng...
Url changed from https://daringfireball.net/linked/2020/03/20/netflix-100m-co..., which points to this.

The site guidelines ask: "Please submit the original source. If a post reports on something found on another site, submit the latter."

https://news.ycombinator.com/newsguidelines.html
is anybody out there actually writing portable sql?
R0 doesn't change. R changes.

basic reproductive number vs effective reproductive number
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But again, follow the money. Where is that exact dollar that would have gone to that business had there not been any coronavirus?

The economy is a circular river system. If it stops one day, there is going to be areas of drought in places, as well as huge reservoirs protected by dams. Money does not disappear, it only moves. You lose money on stocks, someone else on the other side of the world made money with their short position.

Perhaps that dollar is held up in some whale's cash account after they closed their positions. You would tax that whale for that cash, and redistribute it to the working class to afford food and shelter.

In any recession, the big stall is capital being too skiddish to pay for labor, resulting in lowered consumer spending, justifying less demand for labor, and creating a worsened financial crisis due to even lower consumer spending levels. If you are able to keep the working class afloat, you can conceivably keep consumer spending afloat, and therefore keep the economy afloat, even if capital is fearful.
> if you want to have a superhuman composition

You responded to a bunch of claims the comment didn’t make.
Do no harm. This is the first line for a reason and when we deviate from strong evidence we will always find regret. If you've talked with your physician and understand the risks, be my guest.

Until we've done a double blind placebo trial we won't even be able to demonstrate efficacy.