skysight-inc/HackerNews huggingface dataset:
This is an increadibly potent drug with serious side effects according to anything I read, its not first-line treatment its last-line, when everything else fails. You can go blind, irreversibly.

Please people, speak to trained medical people before reaching to the drug cabinet.

I am not a doctor. This advice is not meant to contradict the rule of only taking medical advice from medical professionals.
Could you talk about what breaks in k3s/k3d ?

We have been considering having a desktop -> production cluster on k3s.
Anything that generates a feedback loop where politicians give you tax money to spend on politicians has an instant smell to me. There may be other ways to accomplish this, but that feedback loop stinks to high heaven on initial examination.
Watch out for Chloroquine retinopathy
New kind of CRISPR technology to target RNA viruses like coronavirus
Uhh the last 200 years of IP law is proof regulation doesn't work, the corporations won every battle.

https://en.wikipedia.org/wiki/Copyright_Term_Extension_Act#/...

It was a blow out, the average person like yourself is too politically uninformed to know what to do. The only way out would to get rid of DRM entirely and reform IP law so that we owned our machines and software, you can't have privacy if every piece of software is client-server oriented like PC games have become over the last 20 years.

The videogame industry has been stealing PC game software since the late 90's starting with them rebadging PC RPG's they had in development as mmo's to confuse a lay public, after the early successes of Ultima online, everquest and guild wars 1, that lead us to Valve dropping steam in 2004, a piece of corporate malware wrapped around games. From 2004 to 2009, was the game industry cleaning house as PC games they had in development were either rebadged mmo, or were given steamworks integration, this lead to EA and ubisoft to make Uplay and Origin, more malware, client-server oriented bs.

IF you don't own the software you have no rights to your machine and your software can now be disabled remotely.

Going from dedicated servers, complete software ownership in teh 90's to this locked down dystopian hellscape of steam, Epic game store, Ubisoft Uplay, Bethesda launcher, EA's origin, and Battle.net launcher for activision games.

I have to wonder what you are smoking to think regulation will work this time, when everytime IP law came up for reform it was expanded everytime to remove basic rights of the citizens.
Damn, another hydroxychloroquine user here.

Maybe that'd ameliorate the <70 factor.
Literature for a Lockdown
Amazon is only as good as it’s suppliers. If people can’t get to work to make things, Amazon doesn’t get new stock and they have nothing to sell you.
Thanks for the citation from CIDRAP. I haven't watched the Joe Rogan podcast, but I did read an interview [1] where Dr. Osterholm gave reasoning, basically saying that the science is not in yet on the role that children have in the transmission of the virus. That's fair, though I think that is starting to fill in. For example, in the Imperial study [2] (one of the most important documents of the day), their modeling shows a fairly substantial improvement in deaths from closing most universities and schools compared with not doing so (I'm looking at PC_CI_HQ_SDOL70 vs CI_HQ_SDOL70 on the chart on page 9 in particular). I think we'll have an increasingly solid scientific basis for this decision soon.

The discussion on authoritarianism is one too deep for this comment thread, but I would like to leave you with a question, now hypothetical, but might be less so soon. This virus is a bit of an uncontrolled experiment on the ability of different countries and regional governments to handle crisis. What if the evidence provided by this experiment suggests that authoritarian systems are better able to suppress the virus because they can actually get people to avoid harmful behavior, where in freer systems it's just not possible to get the rate of selfish behavior down to the point of being effective?

[1]: https://www.postbulletin.com/life/health/this-is-not-going-t...

[2]: https://www.imperial.ac.uk/mrc-global-infectious-disease-ana...
That's not how the adult world works. Sorry.
Social Distancing Festival
At ~65 years old, there isn’t much in the way of bootstraps for them to pull up on.
> In CDE there is no really XFT font rendering

Doesn't CDE rely on Motif for font rendering? Motif itself supports Xft for a very long time now.
Keen to know this too. Hydroxychloroquine is the only common -quine drug in East Africa; odd but true, I think malarial chloroquine resistance has something to do with lack of demand/supply.

Additional possible drugs are alluvia, actemra. I think there's a study out for alluvia.

Things to avoid are aspirin (suspected basses on [1]) and ibuprofen (French govt recommendation).

Someone should come up with a summary page of the potential therapeutic drugs and their current state (suspected/in study/recommended)

Sorry for the brevity. On a phone.

1. https://academic.oup.com/cid/article/49/9/1405/301441?fbclid...
Might take a look at the native systemd-machined if you want full blown OSE’s.
It's ironic that the presentation is not very see-through.
Scientists draw inspiration from shark skin for novel new smart material
(NOTE: I am not a medical practitioner, I'm just parroting what I was told in a video)

The Medcram video shared elsewhere in this thread (https://www.youtube.com/watch?v=U7F1cnWup9M) does mention that hydrochloroquine is a relative of chloroquine and is also being administered in some places when chloroquine is not available (at a different dosage). They take pains to point out that they should not be administered at the same time as that can lead to a fatal complication, and also that chloroquine as a treatment overall has not been subjected to a rigorous medical study.
> So is a hotel denying you a refund during an epidemic.

No it isn't. They're not your family, they don't owe you a refund, you agreed to the cancellation policy at purchase time. Abide by the terms or you are the one in the wrong.
AI Is Rapidly Revolutionizing the Healthcare Industry
God forbid people get money to take care of their lives. Because we can afford it.
Hey... things have gotten better in the states in the last few years. Not great, but metropolitan areas have fiber. My old building that was built in 1965 got wired with AT&T fiber about a year ago.
They haven't mentioned effect sizes or confidence intervals. Hopefully it is statistically significant - in which case the effect size has to be large to achieve statistical significance. I hope that is the case!
For reasons beyond my understanding, the internet (or maybe just HN) has been in love with cytokines storms for a decade or so. Far more than warranted by the actual significance of the phenomenon relative to others.

It’s like quicksand in 19th century pop culture.
Yeah, they check my retinas at six month interval.
I see a lot of law on Force Majeure being clarified over the next 12 months: https://en.wikipedia.org/wiki/Force_majeure

Or Frustrated Contract Law: https://en.wikipedia.org/wiki/Frustration_of_purpose

And it's not just for businesses to use against consumers.
No, non-refundable means non-refundable. You don't have a right to expect your money back under any circumstance.
Singapore scientist just published a result on bioRxiv. They have found a 382-nt deletion during the evolution of this coronavirus. https://www.biorxiv.org/content/10.1101/2020.03.11.987222v1
IIT Delhi startup Fabiosys Innovations developing infection-proof fabrics
Video of paper-based bioluminescence detection (Wyss Institute)

"If the sample contains the RNA of the Zika virus, the test area turns purple."

https://www.eurekalert.org/pub_releases/2016-05/uot-rld05061...
Clearly this didn't go the way you suggest in the red zones in Italy.
I switched my local "lab" setup from minikube (which was in use for a long time) to kind recently. The main reasons were

None of us run on Linux which means we're all using VMs for our containers and we all use Docker Desktop for various things. That meant we're running extra local VMs for no good reason. With kind I can just use the one vm for all the container things.

But the real reason for the actual switch was I just kept running into things that minikube couldn't do and Kind could, as well as having things I had decided to ignore like the fact that minikube does everything on one node which is 100% unnatural for kubernetes and I had multiple cases where this setup blinded me to problems that would occur in a real cluster.

3) I've also found I prefer the configuration/customization approach of kind over minikube though admittedly that's kind of a small thing.

Ultimately I find kind is a better simulator for the purpose of prototyping future cluster changes as well as use as a local "lab" for diagnosing services in a "production like" environment 100% under your control.
Then you'd expect the situation to get better in denser areas of Australia far more than it does.
You might want to try a neti pot, because you seem to be missing the smell of the government giving billions to large corporation in a way that accomplishes the same feedback loop you're mentioning.

That is the way the system has been working for decades. For example, airlines have been doing stock buybacks with all their profits for the last several years, and now they don't have the money to weather 2 months of coronavirus, so they'll need a bailout. Then, watch for more stock buybacks and executive bonuses.

You're right it smells, but it's time that graft was extended to the people of this country, who will actually spend it and help the economy a bit, rather than sending it indirectly to the bank accounts of the wealthiest people in the country.
New iPad Pro coming? Four new models appear on Apple China website
There is a demand for air travel obviously but no absolute need. We don't have to stop it completely, just most of it.
It's a model, and a lot can change. In that time frame, it's actually quite reasonable to expect we'll develop effective vaccines and treatments. We might be able to roll out comprehensive and fine-grained testing (as has been done to some extent in countries like South Korea and Singapore).

The alternative is to just let it burn through the population, hoping it takes out mostly economically unproductive people (the sick and elderly), and letting business as usual go on. Some might find this an acceptable policy, but I do not.
If we move to a lockdown the factories are churning 0%.
When administering chloroquine, the hydroxy- form is a very long-lasting metabolite.
These tools are worthwhile additions. Vscode is a important toolkit item for many. Just having it on multiple platforms is a useful common denominator that reduces friction.
The National Center for Medical Intelligence, an obscure patch of the spy world
The test only finds active infections, note.
"Hydroxychloroquine (EC50=0.72 μM) was found to be more potent than chloroquine (EC50=5.47 μM) in vitro. Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-CoV-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance."

https://academic.oup.com/cid/advance-article/doi/10.1093/cid...
Hydroxychloroquine has been used in ShangHai for COVID-19 treatment since February 6, 2020:

https://clinicaltrials.gov/ct2/show/NCT04261517
Top WhatsApp Status Video Downloader Applications for Android Users in 2020
I assume you misread what I wrote, or implied some opinion that hasn't been stated.

I want people to have enough money to live reasonable and modern lives. What I DO NOT want is for UBI to become a political weapon and for the people who rely on it to have it taken away suddenly.

That is a serious risk to that system that doesn't get enough attention. It could happen due to financial collapse or for political reasons. But no matter why it happens, the damage would be absolutely horrific.
> Also NPM is quite a bit bigger than both the Ruby and Python library spaces.

I don’t know, so I have to ask, what’s the metric here?
Yes, his idea of Democracy Dollars is great. Wash out the lobbyist money and allow politicians to run a campaign on popularity without pandering to donors or special interests. Not sure why this idea hasn't gained more traction tbh.
In the US tonic what is only allowed to have very low levels of quinine. The old imperial British stuff might have been effective.
Didn't know that fossil let you take everything. That's worth having.
The Washington Post said 5m out of 35m masks were expired.
Tonic was invented to make quinine palatable to British soldiers in India. About three minutes into the scheme, someone added gin.

So quinine is indeed arguably the original “active” ingredient, sugar was second (to mask the flavor), and alcohol “let’s just pretend this isn’t happening” was third.
You realize the top 1% already pay for a disproportionate amount of the taxes? Also they own businesses that employ hundreds of thousands of people.

To tax people's wealth on top of the standard tax is plain evil, and will end up driving all the wealthiest people out of the country...
Let 'em play!
The retinopathy happens only after years of use (like a decade). Also, as an immunosuppressant, it is pretty slow acting in that it takes two three months to even start working. The currently prescribed dosage for the viral infection is for 5-10 days (albeit at slightly higher dosage than used for malaria/lupus etc.).
It is, force majeure is a legal concept in many jurisdictions and was not invented by toddlers.
Reality is that peak usage (at least in Canada) is in the evening hours. Impact from WFH during office hours will just use excess daytime capacity.

WFH (RDP/Webex/VPN) uses much less bandwidth than streaming Netflix.

But the kids being at home might make a big difference.
Ask HN: Why can't corona testing be done in bulk?
I have often wondered why it isn't possible to combine swabs from large numbers of people and PCR the soup to check for the presence of a virus. In the best case, one can eliminate large numbers (dorms, hospital janitorial and nursing staff) at one shot, and makes frequent (daily) testing possible for people at risk). If the sample tests positive, then perhaps (perhaps..) it is possible to figure out the affected subset in a log number of further tests. Am I missing something?
>the streaming companies will come out alright

Production on new content is shutting down everywhere. Streaming companies will do ok until they run out of new content.
Except a vaccine won't be ready until long after everyone is either dead or recovered.
I agree with what both of you are saying, and if someone is willing to extend credit at ~$60 to the frackers again, it will happen. The question is who… banks aren't doing so well right now (else why the need for JPM at the discount window, more pomo, more frbny broker-dealer repo, and equity on major us banks testing 5 year lows, whos ficc revenue growth at ZLB will be pretty much non existent or even contracting more than it already has).
People generally don’t choose daycare. It’s a requirement because they have to work.
Usually takes years to develop. This is really a non issue for the 5-10 days use in this case.
UBI still does not provide health care.
If there are sectors where UBI gives businesses an opportunity to raise prices, then it follows that there is room for competitors to enter.

Competition will eventually drive prices down and lead to more consumer choice.
This is an old paper, FYI. Published on Feb 20, which is eons ago given the state of things.
From wikipedia.

One of the most serious side effects is a toxicity in the eye (generally with chronic use).[11] People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. The daily safe maximum dose for eye toxicity can be computed from one's height and weight using this calculator. Cumulative doses can also be calculated from this calculator. Macular toxicity is related to the total cumulative dose rather than the daily dose. Regular eye screening, even in the absence of visual symptoms, is recommended to begin when either of these risk factors occurs.[12]
For everything but OTC meds, it takes both a doctor’s and a patient’s consent.
Pointing out the type of argument doesn't negate that argument. While I don't think it's ok to simply commit fraud because I think the company is committing general fraud in most areas... If someone runs up and steals my phone but drops their own, I'll be keeping their phone until they make things right.

The same goes especially for multi-billion dollar corporations.

You cheat me out of something, I will first attempt to right that wrong through the proper channels. If I am unsuccessful, I will right that wrong through unofficial channels. Within reason, of course.
You mean the entirety of corporate America? All those tax loopholes? Agreed, I think they stink as well.

Good thing Yang's Democracy Dollars idea has no strings attached unlike that sticky lobbyist cash.
On a related note, UC Berkeley is looking for volunteers to help them set up a test center using these techniques - https://innovativegenomics.org/covid-19/
I think something similar has happened with minimum wages. It appears to me that the natural next step is to make the minimum wage grow with inflation.

Unfortunately, this hasn't happened, so we're stuck with various government-mandated minimum wage levels that are tied to the value of money from several years before.

Companies can now point to the law, and use this obsolete number as a metric by which to set their own salaries. What was intended to protect the laborer is therefore perversely being used to protect their corporate employer.
"The pharmacological activity of chloroquine and hydroxychloroquine was tested using SARS-CoV-2 infected Vero cells."

https://academic.oup.com/cid/advance-article/doi/10.1093/cid...
Do we know what assets increase with quantitative easing?
Not to mention, conducting a good online course takes preparation and practise (on the part of the teacher).

All these online courses are probably going to be setup over the course of like a week. I don't imagine they will be well run online courses.
Right. The Zinc is already present intercellular, unless the patient is Zinc deficient.
Why, what happened to yarn?
Airform: Functional HTML forms for front-end developers
Do you plan for an ios release anytime soon?
Signing in with Google fails in the app:

403. That’s an error.

Error: disallowed_useragent

Google can’t sign you in safely inside this app. You can use Google sign-in by visiting this app’s website in a browser like Safari or Chrome.
Honestly shocked that people don’t see that as being obvious sarcasm.
A rational move would be to lock everyone down until a vaccine is proven safe and efficacious can be delivered to enough people. Since no one other than indigenous people living near bats have any immunity to beta-coronaviruses, it doesn't make sense to expose billions of people to unnecessary risks when we can pause nearly all social- economic activity until immune defense is possible or supplies run low.

The vaccine, once developed, should be free for everyone to encourage high uptake herd immunity.
Thanks for the article link and the reference to CIDRAP. I'm trying to take in a lot of information, especially views dissenting from the mainstream. These are useful resources.

> It is not the case that "many experts are citing numbers in the high hundreds of thousands to a million people".

You are objectively wrong on this. The UCSF panel on 3/10 presented an estimate with a range of 1.5 million on the high side. Dr. Osterholm said on the Joe Rogan podcast,
"We conservatively estimate that this could require 48 million hospitalizations, and over 480,000 deaths over the next 3-7 months." The Imperial report warns of up to 2.2 million in the US, and even with mitigations in place a large number of fatalities. Not one of the epidemiologists I follow on Twitter has called this estimate into question, and many have praised the report.

Nobody has the real answers, and we all have to do our best interpreting the evidence that's out there, but making shit up is not helpful.

ETA: I found a working link to the 3/10 UCSF panel: https://tincture.io/an-expert-covid-19-panel-from-ucsf-664a3...
Well, it's a new computer so there's no notion of compatibility.

But yes, I'm proposing to rely a lot less on compatibility going forward. A big reason for building a new stack rather than building atop existing interfaces is precisely to avoid backwards compatibility. A big reason to keep the codebase comprehensible is to shift the social contract, so that people can fend for themselves in the face of incompatible changes. By the same token, a big reason to avoid compatibility is so that we don't have to indefinitely make the task of future readers more difficult.

I think the age of computers is just starting. 99.999% of computer use is yet to happen. It seems shortsighted to hamper the future for the sake of the miniscule past. You wouldn't want to force the adult to hew to the short-sighted decisions of the toddler.
What's your useragent?
Senate Leadership Is Pushing Through a Dangerous Surveillance Bill As
Ohh, but then the UBI recipient may use it to purchase something that Big Brother doesn't want them to buy... like using SNAP to buy hot food.

On a more serious note, yes. Beyond basic necessities like healthcare and education, that the government would like to micromanage lives of welfare recipients feels demeaning in the extreme.
> Buybacks are an accident of tax law and ought to be taxed the same way as dividends.

The problem is it's really the other way around -- reinvested dividends should be taxed like buybacks, i.e. taxed when the purchased shares are sold.

By contrast, taxing buybacks like current dividends would create a really grisly incentive for corporations to hoard a giant pile of money, since that would be the remaining way to defer the tax. This is already what international corporations do with offshore profits because of a similar incentive to defer corporate income tax, and it's a huge problem.

We have a policy of allowing people to avoid tax on investment gains until the investments are cashed out -- this is what a 401k is all about. We might as well make it consistent across the board so it stops creating all of these perverse incentives. (That would reduce the amount of tax collected, but it would also remove most of the justification for taxing capital gains at a lower rate than earned income, so changing both at once would about balance out.)
Is wrong to do?

That's a question of morality. Canceling a hotel stay by giving them an acceptable reason doesn't feel wrong to me. They can use that reason to claim government to rebuild money after all of this.

Lying is a legal sense is very different to just lying or not telling the truth. Not sure many judges would side with the hotel. Not sure the hotel could prove bad faith. I'm very sure the cost of a suit would be higher than the cost of the refund.
Can you explain like I'm five how you plan to perform this tax loss harvesting for years to come?
more samples together increases offchance of crossover contamination producing a false indication.

under the assumption that a corona virus case displays symptoms around day 5 it doesnt make any sense to test if the results come through at the same time as symptoms would arise in positive case.

in my area there is a claim of 3 days shipping of a sample before tests are performed and results submitted.

if you have a lot of samples, abunch of 96 , and 48 well sample trays then bulk testing is efficient if you are careful. If you have to wait, to accumulate samples for a batch, that is not soon enough.