skysight-inc/HackerNews huggingface dataset:
Checkout this book [1]. It contains myriad of sources and footnotes about how the developed world, WTO, World Bank etc function when you live outside. I.e. Undeveloped countries are slaves to keep the rich countries rich.

[1] https://www.amazon.com/Aid-Other-Dirty-Business-Intentions/d...
Looking at the assay - it uses a dual labelled probe. That gives the specificity in addition to the PCR primers. Primers themselves presumably aren't selective enough.
It does not follow that because all people are flawed that she was a monster nor does it follow that since some people have been portrayed inaccurately that she was.

>The true heroes are the ordinary people who labor away in anonymity. There has never been a truly good person on the BBC or any major "news" site.

This is fetishizing following different biases as being an individualist.

If the mainstream press reports 2 + 2 = 4 saying it's 17 isn't brave its a failure of analysis.
> Agree it's trivially easy to do, but as anyone you does a lot of qPCR knows, they're rife with false positives.

Honestly we'd be better off having a widely available test that gives 50% false positives. Worst case, a bunch of people quarantine unnecessarily, but we at least catch all the infected. The alternative is what we have now: widespread community transmission with no end in sight.
Housing courts will likely not be processing evictions. You'll be incurring some nasty debt (and so will your landlord, probably) but not physically transferring possession.
Just my 2 cents: I tried using Couchpotato for a while and it was one of the worst pieces of software I have ever tried to use. Confusing UX/UI, I never could understand how and when it was actually searching for movies etc.

I switched to radarr[1] and I never looked back. Although I hate having mono installed in my server, at least I can manually perform searches to check if it works until I was satisfied that the "Monitoring" feature actually works. And I find the UI much more understandable too.

I also use sonarr[2], which is also pretty satisfying for me. Although SickChill looks much better and more feature complete; I will look into it when (if?) I manage to get back home.

[1] https://github.com/Radarr/Radarr
[2] https://github.com/Sonarr/Sonarr
Docker for WSL2 will be supported with windows home edition. There was an announcement recently : https://www.docker.com/blog/docker-desktop-for-windows-home-...
Your inability to put a price on human life is precisely what is leading you to discount future lives.

Economic downturns lead to deaths of despair - long-term unemployment causes spikes in suicides, drug overdoses, even domestic terrorism brought on by a potent mixture of sheer nihilism and depression. Just because it's more difficult to count those future lives (more likely to be young) against a current model - who are you to discount them?
It's weird, right? I spent some time last night trying to figure out exactly what the mechanism is that chloroquine has when it works. It looks like there may be more than one mechanism in place.

In the malaria parasite, it kills the parasite by hitting up the lysosome (or something intracellular at least - interaction with a protein, can't remember details).

In humans, things get a little bit more fuzzy. It accumulates in lysosomes, and then how it stops Coronaviruses or is effective in lupus treatment isn't very clear. I've seen arguments that it changes pH, or the caspases can't work any more, but that doesn't explain very much.

My bet is that it's screwing with the organisation of the secretory system, which means that virus can't get out properly (maybe budding is broken).

The ABO blood system link is something else altogether, but probably hints towards other functions of blood type in regulating something other than self/other recognition (although virus itself may carry ABO epitope).
Yes, that's correct, all distros use ip and have for about 15 years.
Google is removing bad Zoom reviews
I just rated the app and wrote a short review which was a bit critic towards its high battery drain and resource usage. And suddenly it was removed! After a short search it obviously something Google do now...

https://www.androidpolice.com/2020/03/19/zooms-android-app-rating-has-been-absolutely-destroyed-by-coronavirus/?amp
"Americans are a unique people, our spirit cut from a different cloth than that of other nations."

How rich and deep thought! :)
Possibly because you forgot to reduce the R factor. If you infect people over 1/2 the time, perhaps you need R to be 1/2 what it was before.

I assume that the model is spreading the people you infect across the time you are infectious.
This will go back and forth for years.

The truth is the world is too complex and both sides will make mistakes.

Thanks to complexity, the solutions will be incomplete and half baked. Such solutions will create their own issues that can compound the original issues.

The CHOICE will always be to spend time highlighting each others weaknesses, mistakes, indulge in blame games OR to admit certain problems are above everyones pay grade and should not be touched until simpler subsets of such problems are handled.

As anyone anywhere in the world who has lived in a dysfunctional family knows, hard problems cant get solved when mom and dad don't trust or respect each other.
I remember as a child our school were offering £20 to student teams wanting to run a business for a week, with the team that turns over the greatest profit being the winners. Unfortunately as we were limited in skills and ability, the best project was a car wash.

I wish they run these types of projects in Colleges and Universities, where students are more skilled and motivated to work further out of the box. I would have loved to have been given £20 to buy a little server, a domain, etc, to build some small product over the course of a month with some friends. Hell, turn it into a coursework for programming, project management, etc.

This kind of thing seems like a low-cost, high-value exercise for students to begin to understand the difficulties of business (most will fail - but that's okay).
People are in shock. Shock doesn't last two months. And don't forget all the people you don't see at the supermarkets.
Comparison is flawed.

Getting demand is harder than scaling.

In this case the demand already exist and the money to scale as well.

In short, the question remains. If there is a will to scale, what is the holdup? People with experience?
Wow 30 passes in 19 seconds
That's about 14 days of people dying at normal USA death rate. Do you think people notice that happening and adjust for it?
> I do know what a plea is. Legally, this calendar is the only thing he stole.

In the criminal trial yes.

> I understand Google made many claims but apparently the evidence was only strong enough for this one minor article to make through the plea negotiations.

Google isn't (officially anyway) involved in this plea deal. It's between levandowski and the DA who is charging him with a crime. Google won 170 million in damages in the civil suit/arbitration.
Daniel also addressed this some, but I want to highlight that sorting one array of size 2n faster than two arrays of size n does not imply per element time decreasing to zero. E.g. if the runtime were n-2^(-n) you would have that property even though the per element runtime tends toward 1.

<rant>
That kind of phenomenon (reading too far into an infinite process) is ubiquitous once you start noticing it. Infinitely many universes don't imply the existence of every possible universe (if you subscribe to such theories), pie having infinitely many digits doesn't imply that it encodes every possible message somewhere in those digits (most real numbers have that property, but iirc it's still an open question for pi), and so on.
</rant>
Simple, check this log scale chart of COVID-19 cases excluding China: https://pbs.twimg.com/media/ETgWL8rU8AA3OML?format=png&name=... They multiply by 10 every 14 days. So assuming governments did not take any action to change this trend, cases would multiply by 10^4 = 10,000 over 8 weeks.

There are urrently around 675 cases in California according to the CDPH (https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/Immunization...). So this trend would lead to 6 million cases in 8 weeks. The governor probably assumes there are 4 times more cases than detected. So 6M × 4 = 24 million.
Not zeros, but time.
That's a valid idea, but it's unfortunately not something she's in control of. All the PPE protocols are coming from people higher than her.

They're also not getting eye protection at all so she's taken to wearing her glasses instead of contacts. Not as good as actual eye protection, but it's better than absolutely nothing.

In short, they don't have what they need.
Apple limits online iPhone purchases to two per person amid coronavirus
This is an interesting tradeoff to consider. Under many many circumstances I could see that rate of false positives being awful and intolerable.

In the context of a bona fide pandemic with a massive shortage of desperately needed testing, however, this would be a palatable improvement upon the status quo.
> Then you're out of step with what users want these days.

Two things:

1. The person you respond to is also a user, no reason to dismiss their point of view

2. I don’t think browsers asked users for what they want! It’s a bit disingenuous to say “that’s what users want” when the communication is one way only.
But can this be done without abandoning capitalism as a primary driving economic model? It would require a reversal in economic steering (tariffs, government intervention, etc) of enormous scale. The only thing that has come to matter is the hunt to squeeze every penny, we have forgotten to do anything else.
What would happen if all internet access was cut off, especially now
Suspend/delete accounts (and all listings) for anyone with a single violation.

Problem solved.
I thought the same, the JSTOR incident initially brought me to HN. Discussed at the time:

https://news.ycombinator.com/item?id=5046845
Shibori (絞り, also 搾り) is, first and foremost, simply the noun form of the verb shiboru (絞る, 搾る): to wring, squeeze, press, extract, strain out, contract ....

A camera's or eye's iris/aperture is also "shibori", because it contracts to constrict light.

But the most important shibori, vastly overshadowing quaint tie-dying art forms and camera apertures, is "ichiban shibori": the first press of the malt in beer-making.
"When in trouble, or in doubt, run in circles, scream and shout."
Deploying NixOS to Amazon EC2
Looks like they took down the link, is this still in effect?
That was the case for Italy until 4-5 days ago and I think it still is for Spain, definitely for Germany.
Companies Retool Operations to Assist in Coronavirus Fight
It's best to assume that as a rule, people don't get meaning from work that can easily (if not inexpensively) be done by a robot.
It's usually quicker and easier to determine how much each person reasonably needs to get them through an emergency situation, than to predict how high the price could be driven by hoarders and scalpers. And handouts to poor people to cover the scalper's surcharge will quickly result in the scalpers charging that much more—cf. college tuition, for a non-emergency example.
It is a fascinating art form. You can learn more about the different techniques here - https://www.hilarylhahn.com/blog/3-shibori-techniques
We've been running a longitudinal self-reported diagnosis, conditions, and risk exposure study. There are many challenges in this [0, 1], but plan to keep collecting into the foreseeable future. Currently operating on a global scale, but could be targeted to a specific geographic region.. - M (max@generalresearch.com)

[0] https://www.bmj.com/content/351/bmj.h3480.full
[1] https://bmjopen.bmj.com/content/1/2/e000234
I doubt it's the lab techs that are in short supply. It's probably the consumables and reagents that go into the test that are out of stock. Lab procedures scale pretty well (to an extent - not the scale of the pandemic). Lab work is often feast or famine in terms of sample volume. During normal times, spikes usually just means the folks running the assays will be particularly busy.

With all that said, there's still a lot of specialized skills required to competently run these tests. You'd still need significant training if starting from nothing. But there are enough un/underemployed lab techs out there that finding more techs won't be the bottleneck.
Everywhere in the world but China, flu caused pneumonia is posted as flu cause of death. But China would list it as pneumonia, so you have to guesstimate flu deaths by a fraction of pneumonia deaths.
How do you engineer around a backhoe operator cutting through a backbone fiber and knocking out the cell towers for an area?
There are also not nearly as many tests being run as there are patients with suspect symptoms. Yes, the number of confirmed COVID-19 patients may be low, but that doesn't mean that the number of people with the disease is low.

According to the CDC[1], you can contact your healthcare provider for the possibility of a test if (and only if) you are in close contact with someone with the disease or if you're in a community where there's ongoing spread. That's still a very limited subset of people who might have the disease.

There's very limited insight into who does or does not have the disease in the US.

[1]https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/t...
The only real facility for high volume production in the US is 3M in Minnesota, I believe. Current estimates place supply chain matching demand in 80-90 days (though I don't know if that's domestic or worldwide).
Dude take a breath, millions die in the US every year
The article mentions a `duct` abstraction several times but I've never heard of this nor been able to find anything relevant through some searching. Does someone have some insights on it?
Due to the outbreak global supplies will be disrupted also there are people that take it as prescription medicine for arthritis, its relevant people to have access to the synthesis of it. Here is a paper describing cost effective way to synthesis it [1].Its not trivial task but good information to have access to. Had a quick look at the precursor chemicals used in this synthesis they are sold from global chemical suppliers and doesn't seem to have any specific restriction for sell.

[1] https://www.beilstein-journals.org/bjoc/articles/14/45
Tariffs result in domestic industries that can't compete. Germany has an export oriented manufacturing sector that employs lots of people and the US doesn't not because of Chins but because of US management.
WHO global influenza preparedness plan [pdf]
Wikipedia links for disassortative immunological mating:

https://en.wikipedia.org/wiki/Major_histocompatibility_compl...

https://en.wikipedia.org/wiki/Genetic_matchmaking
Scammers scamming scammers, what could be more delightful to watch? But sadly this is nowhere near Madoff’s heist, it had a promising beginning but the protagonist soon got sidetracked by drugs and a lavish lifestyle. Why is this even news? This is the price of doing this type of business
Look at farming subsidies as an example.

The government funds some percent of our food production by putting in place limited price and production controls for American-produced goods.

The hand of the market is not completely removed: producers still want to be as efficient as possible. The cost of food has gone down over time. And inefficient producers still go bankrupt.

Is this a good model? I have no idea. It certainly has drawbacks. (Ex: we subsidize too much corn and wheat.) But the US can feed itself without China or OPEC, so that's nice.
As a software engineer, permanent WFH sounds great. As a young adult thinking I should build more cooking skills, this is the perfect opportunity. But as a household of one, isolation is terrifying. I'm not sure how long literally zero human contact is sustainable. I hope we can at least re-enable 1:1 social visits at home before too many months pass.

It's also hard to imagine that couples who live apart are actually going to stay away from each other until the vaccine.
The 2:1 setup was used to save lives after a mass shootings in Las Vegas a few years ago. They paired patiets of similar size, put them on the same ventilator and double the flow rate.

It was mentioned in a blog post by an ER physician linked from hn back then.
US stock market falling faster than during the Wall Street Crash
GroupMe is still extensively used at universities. I only know a few undergrads who prefer to use it, but most seem to use it as a compromise. I personally hate its UI.
> Again severe failure on the govt’s part.

Just imagine how bad it would be if we turned industry over to the government to run, too.
(physician here) Vents can be quite tricky to get right; primarily because as disease progression continues on many things change. We are always trying to balance the deleterious effects of the intervention (in this case, the vent) with the goals of care.

What most people don't know is that vents cause a lot of injuries on their own. (See ARDS). Hypoxemic respiratory failure is serious stuff, and it's almost always not the only insult we're dealing with. So, it's about balance.

In the feedback loop is a lot of things. Certainly, oxygen saturation is a core measure, but we are also thinking about things like hypercapnia (and acidosis); overall perfusion status (blood circulation); infection management; etc.

Gas exchange is important, but there are a lot of things that have to go right for the lungs to take oxygen in, get it into the right transport, and get carbon dioxide back out. You can over-optimize for any of those at the expense of the other (see: hypercapnia).

In short, it's complex and there isn't a solid formula that will work for every patient. It's actually the subject of a lot of debate on details (some of it quite passionate in our Critical care / pulmonology community). This is why we call it PRACTICING medicine ;)
I drive passed it regularly.
I’ve pondered lining my entire bathroom with aluminium-bronze sheet.

It keep itself fairly clean!
Covid19 Open Datasets
Well, my wife is an exception to that. She installs all kinds of crap apps on her phone.

And we got our phones through our daughter who works at Verizon, so when my wife moved from an Android to an iPhone they called me up and asked for my iCloud password which I, like a dumbass, gave them.

I just checked and I've got four more bullshit apps on my phone I need to delete :D
What 2007 Lil Wayne can teach entrepreneurs today
CDC 2019-Novel Coronavirus (2019-NCoV) Real-Time RT-PCR Diagnostic Panel [pdf]
Ignite 2.8 Released: Less Stress in Production and Advances in Machine Learning
I admire your optimism that the economy will not shut down when people are found dead at homes because hospitals are full. Which is what's going to happen if we let it spread now.
Not really. The similarity of the shibaru and shiboru verbs is probably not accidental. One refers to tying or binding, the other to wringing, squeezing. And in fact, shibori is something we might call tie-dying, a literal translation of which would therefore like to go to shibari.
This is what people were talking about in the beginning of the pandemic but, if anything, all this has taught us is we should invest even more deeply in global supply chains. If US made most of the masks that the US needed, then we would be shutting down all of our mask making factories right when we needed them. Because China makes our masks, China can buy global masks while they were locked down on a pandemic and now they can turn around and be the factory for the world while everyone else desperately needs masks.

What we should be wary about is Single Points of Failure but we should be worried about that regardless of what the supply chain looks like.
But that radical is "thread", and both have to do with actions that can be done with cloths or ropes.
This is the most excellent description of South Korea’s efforts I have read so far.
GameStop tells employee it's 'essential' and can stay open during lockdowns
What I'm getting at is that if you're talking tens of thousands of dollars for an order there's a far greater number of people who can put an advance towards that than if you're talking hundreds of thousands or millions per order.

Hospitals (public and private) in the Bay Area are publicly talking about sourcing PPE from non-medical vendors (e.g. construction companies) and nurses are protesting in front of hospitals. Seattle area hospitals are making their own. All of which is to say I think that procurement guidelines will be dramatically relaxed.

If you can ballpark it I'll ask around.
It isn't?

https://en.wiktionary.org/wiki/academical

https://www.collinsdictionary.com/us/dictionary/english/acad...

https://www.merriam-webster.com/dictionary/academical
Ok, grammar nazi alert. Who uses the word academical? I had to google it just to confirm it is indeed a word, albeit a rarely used one that is indistinguishable from the simpler, and in my opinion, the proper word, “academic”.

A bit like saying “that’s nonsensical” vs “that’s nonsense’. https://wikidiff.com/academic/academical
This is why their stock market is the best performing in the world this year...
> But it’s also the optimal solution to handling demand for numerous other reasons. See https://fee.org/articles/let-prices-rise-to-combat-the-coron....

Markets are not efficient. Especially not on short timescales where even FedEx deliveries aren't quick enough to reallocate supplies and keep shelves from going bare. And especially not during an emergency that is very obviously triggering widespread irrational behavior. And especially not when consumers are working with insufficient information, because literally nobody on earth knows to a high degree of certainty or precision just what degree of risk we're facing.
There is a huge difference between confirmed infections and total infections because it is estimated that around 18% of the people never notice that they are infected.

But those that get sick get very very sick. And this will put much pressure on health care.

The fear is real. Take a look at the footage of Chinese hospitals and doctors.

Without lockdown the numbers will go up in 8 weeks.
The funniest thing to me is that the twitter account complaining is a Microsoft employee and Github is owned by Microsoft but the only way he could complain and be heard is via twitter? Amazing!
Why don't they just charge a higher price to buyers who don't pay cash now? I understand there is a lot of demand, but this does not compute with me. My spidey senses would be going off.
Instagram is testing self-destructing messages too
You seem to be talking about voting patterns while I'm talking about cognitive biases leading to bogus generalizations. Those seem like two distinct "it"s.

As for voting patterns, I'm not sure I agree. For example, it's not true that downvotes used to be reserved for something factually incorrect. The voting mechanisms are subject to the same psychology as they always were.

Your comments often argue in edgy ways that are not exactly in keeping with the spirit of this site. From my perspective that's more likely why they're getting downvotes. I took a quick look and your comments that I saw which were upvoted don't seem to have this quality. Usually, when people complain about downvotes, there's something in their comments that they're not aware of, but which is apparent to readers. Of course there are also downvotes simply because of disagreement, but all comments get those, and they usually get fixed by corrective upvotes if there's nothing else in the comment that has a downvoteable quality.