skysight-inc/HackerNews huggingface dataset:
It seems like the title may be misleading:

"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients."

This seems like:

a. This would have no prophylactic benefit (to avoid infection or reduce early symptoms)

b. The benefit would only apply to people who are already in the late stages and experiencing a cytokine storm

As hydroxycholoquine is immunosuppressant, I might suspect that its use in non-critical cases could actually worsen outcomes by suppressing the functioning immune response. As someone who was looking into it as a potential tool in the prep kit, I think this is likely a drug that is best administered only at the discretion of a doctor.

Would love to hear opinions from others who are more knowledgable though.
https://factcheck.afp.com/chloroquine-has-not-been-approved-...

Some enterprising Nigerian has apparently been trying to illegally sell it in the UK at least.
Yeah, almost. That's essentially my current preferred stack already. But "almost" is the key word: sometimes there seems to be some overlapping duplication of functionality, if not necessarily code, and the handoff between Rails-world and Vue-land is still a kind of purgatory which can be solved and navigated with experience and knowledge of the ins-ands-outs of both frameworks / webpack / package management / etc., but it'd be _nice_ if all those options were solved in the first place, rather than having to work to cleanly and sustainably get two frameworks to talk to each other nicely.
The city probably didn't plan that someone puts a hotel in the middle of a residential area. This is exactly why airbnb hosts tend to get into legal trouble in some countries.
The way it works best is when you have multiple accounts ,you have a single Identity account, which is where your user accounts live. This account basically allows sign in and assume role - oh and you can't assume unless you have authenticated with MFA.

Then, all your other accounts - dev, prod, service, whatever - simply have roles and no user management overhead - i.e you aren't duplicating users in a bunch of accounts and having to deal with a bunch of different identities.
For holidays booked without too much time ahead that's fine, but for work which is easily cancelled or postponed, it's impractical. I'd like to see a premium price offered with more flexibility on date changes.
You just described every single investment.

:)
For a slightly more balanced perspective, try this paper: https://www.sciencedirect.com/science/article/pii/S016635422...:

Highlights from that paper (all of which look quite reasonable to me, as a non-expert):

• In vitro data suggest that chloroquine inhibits SARS Cov-2 replication.

• In past research, chloroquine has shown in vitro activity against many different viruses, but no benefit in animal models.

• Chloroquine has been proposed several times for the treatment of acute viral diseases in humans without success.

• The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data.

• Peer review of the results and an independent assessment of the potential benefit for patients are essential.
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This is irrelevant to what I am saying. I am not talking about whether what he did was illegal, I am just saying that he did nothing wrong. After all there is nothing wrong with a lot of things that are or were illegal.
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You think the internet is going to be compartmentalized before USD is devalued?

Fed is printing $4T this week!
What kind of program requires that much ram?
I prefer to have an additional layer that is usually called the service layer. You use it to express and orchestrate the actions of your application without hard dependencies on specific tech.

So the application layer is the one that manages specific dependencies and injects them into the service layer and the service layer then goes:

- okay, when asked to disburse a loan
- I construct a domain object for the loan
- If the object is valid, I make a sync call to deposit the money
- I then persist the loan
- I then send a notification that a loan is disbursed

And it doesn't really know how the RPC, the notification, or the persistence layer actually work.
$11.5 trillion dollars has been wiped off the stock market in the past few weeks[1]. That's not just the virus because there's an oil price war going on too, but it does seem like suggesting it'll be back to normal in 6 months implies you don't understand the scale of the problem.

[1] https://markets.businessinsider.com/news/stocks/stock-market...
I have a number of cloud enabled cameras now, but I’m also building my own system to keep everything local-only.

If you want to sell me an ML-based system, you’re welcome to train the models in the cloud, but they have to run on local-only assets. And you have to give me complete control over downloading new models periodically to a machine of my choice, and the updating my local devices.
At some point all that "nah what's the advantage of knowing that exactly?" would pile up and we throw away to many questions of how things work, limitting progress. I think that these kind of things are what scientists want to know. "We" want to know everything and how it works, no?
All this talk of iPhones, but what about Android? Is it trivial (or possible) for a nation-state to access the data from an encrypted android device?
One of the main characters (Aaron) fled the country and is seen with the people in the warehouse presumably making a bigger version of the machine for unknown reasons.

The other one (Abe) stayed back and kept on trying to travel to the past and messing around with the machine so that his (and Aaron's) past selves will eventually give up assuming that the machine doesn't work. But this seems to have been thwarted by one of the future-Aaron's as he has sent a recording detailing the whole scenario to some unknown recipient (this recording serves as the narration of the movie).
Just because that’s your model today, that doesn’t mean you won’t get bought by another company whose sole purpose is to use all assets for gathering as much private data as possible and using it for their own purposes.

If you want to sell to people who actually care about privacy, then you have to build your systems so that it is impossible to abuse them or use them in any other way. Or, at the very least, it is extremely difficult to abuse them.
It sort of does. Please have a look at the Infektionsschutzgesetz: https://www.gesetze-im-internet.de/ifsg/BJNR104510000.html (infection safety law).
Yes I think that makes sense. If you have real economic growth that can cause E to rise and through that mechanism P to rise. But even without economic growth, by reducing expected returns, you can keep E constant and get P to rise by increasing the P/E ratio. My sense is that historically the first mechanism was more important, but in the last 10 years the second played an important role.
To me decoherence always seemed so obviously the solution to these 'problems in QM' that I genuinely don't understand why are still having these quasi-scientific discussions. Am I missing something or is there a ton of uninformed arm-chair science going on?

What are the scientific arguments against decoherence?
What do up-to-date theoreticians think?
> I hope that whoever created int max(int a, int b) is benevolent because just about every programmer has reinvented that at some point. What about Response get(String url) which returns an HTTP GET response. We have probably all written that at some point and most HTTP libraries implement it.

FUD. You're using extreme arguments that traditional copyright law handles them well. API functions like "max" or "get" are so basic and general that they would not be protected by copyright law because they are not original "creative" works... a "max" function can only be written in a few ways that don't really rise to the level of creativity.

However, a massive amalgamation of functions and classes, could be protected. I don't see any theoretical reason why they shouldn't, just practical ones based on what the software industry has expected as standard behavior.
Show HN: Added a leaderboard to my old iOS game
If you also sell the optional local storage device (a network video recorder), then at least you give your customers the option.

Otherwise, you are not materially different from Ring or Google.
You might find this long-form article attempting to make an argument against “bitcoin has no intrinsic value” skepticism:

https://medium.com/coinmonks/bitcoin-has-no-intrinsic-value-...
California can seize hotels in Newsom’s new coronavirus order
Where is "around here"?
That may very well be. So correct me where I'm wrong here.

The Fed prints (or issues) currency, lends it to "the state" at interest.

The state eventually pays at least a part of that money back.

All I'm assuming is that if that paid money doesn't vanish, then the Federal reserve will have a Federal reserve containing that money.
I use Postgres + PostgREST.

PostgREST is an amazing tool for cutting down all the middleware you’d normally need to build.

A bit of a plug but I’m also building supabase.io which gives real-time functionality to Postgres (like Firebase)
> suggesting it'll be back to normal in 6 months implies you don't understand the scale of the problem

No one knows the scale of the problem. It's the uncertainty that's driving the volatility.
The foundations of mindset theory appear to be overstated
Romania, which is also severely underprepared for a real outbreak. At least they're locking down borders and checking people, there's a lot of them going to/from work around the EU.
Y Combinator: AtOmXpLuS
Epic Games buys facial animation company Cubic Motion
Well, the determinist would argue, that, if you cannot predict the result reliably every time, you do not actually know all the variables, even if you think you do.
Many would argue that a "better" digital currency has already been created, yet Bitcoin remains at the top. I don't have much in the way of opinions here it's just an interesting aspect of what makes a digital currency more or less valuable (that is, it doesn't _seem_ to be how much better the tech is)
Absolutely, same goes for anyone else who comes across this and is interested in kernel development.
It’s not only in Canadian politics but in most parliamentary republics.

The US doesn’t have a direct equivalent but the closest one would be the minority leader.
I understand your comment has and smiley indicating you are not completely serious, but I think I still need to point outthat your comment is blatantly untrue.

For example, see fixed income and dividend paying companies.
Everything in AtOmXpLuS.CoM/X
> look at the proliferation of desktop GUIs in the late 80s and into the 90s. Everybody was throwing in gratuitous differences in the hopes of making their look and feel "different enough" to avoid a lawsuit. So we ended up with a mess: swapping the location of "OK" and "Cancel" buttons, every platform's scroll bars behaved differently

I don't see this as a mess at all. I see this as very positive experimentation and eventual consolidation. Would it really be better if one company came up with a GUI and everyone latched on to it?
RediSearch Version 1.6 Adds Features, Improves Performance
> people who think that people cannot grow

I don't believe that these exist, which was the point. Everyone knows that people can learn things and become more skilled, claiming that some people don't believe this is straw-manning and hence bad science.

It is true that some people give up and stop growing, but I don't believe at all that it is related to "growth-mindset". More likely they just feel that the growth isn't worth the effort, they are happy enough where they are. Claiming that these people lack "growth-mindset" is like claiming that people who fail to reach their fitness goal lacks "growth-mindset" instead of just lacking motivation to work hard but still having enough motivation to talk constantly about it.
Not really. Many types of investments also return value through investments or dividends.
Madrid has cold weather up until Tuesday - https://www.accuweather.com/en/es/madrid/308526/march-weathe...

It’d be interesting to see if the warmer weather since Tuesday will reduce the number of new cases. If we assume a week between exposure to getting diagnosed, we would start seeing lowering rate of new infection starting from mid next week.
You missed the point.

Holders of gold maintain custody at risk of physical confiscation.

Holders of Bitcoin maintain custody (of the password that allows spending said Bitcoin) and are cannot he compelled one way or another. The bitcoin moves when they say so.
That's the point. The people making the above arguments are unsympathetic racists. The fact that a subset happen to be members of the group they attack is quite odd but still just as wrong as others making those arguments.
How are the two things related?
From the Association’s website:

> The Copper Development Association Inc. (CDA) is the market development, engineering and information services arm of the copper industry, chartered to enhance and expand markets for copper and its alloys in North America.

So, it is a marketing arm. I don’t see how this would be any more reasonable a source of info than the Egg Council for eggs.
There are existing commercial solutions that can address the HoA use case you describe here. Lots of smarts in the local NVR device on the network, or in the admin station that connects to the NVR device — follow the person in the yellow jacket, ALPR, and so on. Then you can easily add off-site storage, or whatever.

The problem is that these commercial solutions are expensive.

You could try to build your own with OpenCV and other tools, but that’s a really hard task if you’re not also selling for the same kind of money.
I can't find a simple historical total return index on a free source but here's a calculator[1]. It says to me that 100% dividend reinvestment in the nikkei since 1974 would give you a total return annualised at 3.2% in yen and about 3.6% in dollars. Most people would have significantly better hurdle rates than that. So investing in the nikkei if you're a yen or dollar investor has been pretty average over the long term no matter how you slice it.

[1] https://dqydj.com/nikkei-return-calculator-dividend-reinvest...
Open Source vs. Basic could not be more confusing. This seems to be a Basic licensed product, which I guess means hosting companies can’t host ECK on behalf of anybody?
For reference, this is the site I found that went back farther. Milan is not constant days of 150, as Hubei is. That said, it is littered with many high value days. Contrasted with Seattle, which has been steady below 60 for the time period.

Take this over to Australia [below], and you can see that even they had terrible air as recently as mid January.

Contrast to Norway [also below], which has hovered on fine air quality for the entire time. Same for Japan, all told.

Basically, the worse your air quality, the more severe cases you are seeing. To a marked degree.

Edit: Just eyeballing, Milan is worse than Seoul. Agreed not as bad as Hubei. But between.

Seattle: https://air-quality.com/place/united-states/seattle/9e80e347

Hubei: https://air-quality.com/place/china/hubei/7991f3c2

Milan: https://air-quality.com/place/italy/metropolitan-city-of-mil...

Australia: https://air-quality.com/place/australia/victoria/def9c265

Norway: https://air-quality.com/place/norway/troms/a70875e7

Japan: https://air-quality.com/place/japan/tokyo/c8969bc2
The cost is significant: introducing one more level of indirection (for tagging) is not cheap.

However, Maybe can be implemented without tagging, see[0] for example.

[0] https://hackage.haskell.org/package/unpacked-maybe
>lots of patients get sent to the ICU, seem to do better on "flolan" then die of cardiac arrest

Didnt doctors in Wuhan discover the same thing? Why is Italy repeating this mistake?
Read “The Hot Zone” by Richard Preston. Great book about the origins of Ebola that culminates in an outbreak in Reston, VA that was primarily handled by the military. (The only reason you haven’t heard more about his particular outbreak is that it turned out to be a strain that only affected monkeys (450 at a scientific research holding facility in this case).

https://www.amazon.com/dp/0385479565
Complex solution for a simple problem. I'll sound naive, but I think that quantum entaglement is a very simple thing: it's a link, like an edge in a mathematical graph, between two particles. The length of the link is 1. Not nanometers or something else, just 1. The particles rapidly change their state, but they are synchronized via this link and at any moment they are in the opposite states. Measuring one particle is done by bombarding it with another particle, which stabilizes its state, and also the other particle, via the link. In other words, our world is just a mathematical graph that appears to have continuous properties at scale.
sorry that you had these experiences, i can relate to aspects of them as well.

each meeting can be quite different. i had to try 10-20 of them in my city to find a few that were on my wavelength.

i don't attend aa meetings as often as i used to in early sobriety, but i still go if i have a friend that's struggling and want to open this resource to them.

at every meeting, there are things that people say that resonate and things that are cringe-worthy or even inflammatory.

part of the meditation and process is being able to be hear and react to everyone's words with equanimity.
SARSCov2 is the virus. COVID-19 is the disease.
Yes, that's how one studies these things. The models we have in simulation are far too crude, so scientists are forced to make the real versions. I have a friend who does this with tuberculosis to study how it develops resistance to drugs. Part of it was trying to enhance or block certain genetic pathways, and yes, sometimes it results in tuberculosis strains with much higher adaptivity than normal. This is how we learn what the pathogen uses, and, hopefully, how to stop it, or at least how not to make the situation worse.
I think they also rightly recognize that Congress exercising its extremely rarely used right to use force could be the first step into either civil conflict (escalating to war) between the Executive branch and Congress or the further neutralizing of congress leading to one-man-rule of President as Emperor.

There are many who hear me talk about such things and think I'm absolutely crazy, but I think people have such faith that things will always end up fine (because America has been stable for so long) that they will ignore every sign until it is all but complete. History may see this week as one of a select number or crises that lead to ... something.

I fully believe that Barr actually in his heart and mind wants and is acting to further it. Trump as well. The cowardice of the House and the politeness of the Senate are just as culpable.

The Democrats meanwhile now have a choice between an out of touch old man who was the conservative VP to make Obama a little more palatable and a near communist who promotes himself with plans which don't represent the interests, philosophies, or desires of a large majority of America and could never, ever pass into law.

If we are lucky, the current pandemic will infect the three of them before the election. If we are unlucky, I believe we are very close the American Republic on the path to fall within 40 years into... something.
Beginner's Guide to RxJS and Redux Observables
Recruit an expert to train your AI/ML models
Ask HN: Are people considering Corona parties (a.k.a. Pox parties)?
https://en.wikipedia.org/wiki/Pox_party

It would allow much safer control measures for yourself and the community rather than something that's predicted by some to happen at a 70% chance at a random time.
EEPROM. And there has always been a reflash method for bricked firmwares for all AMI and Phoenix BIOS' as well. Insert disk with firmware, Hold a key, power on.

Once upon a time we got somewhere in the neighborhood of 1200 dell workstations and not a single one failed the bios upgrade. 10/10 would do again
https://news.ycombinator.com/item?id=7656282
Covid-19 Health and Wellness Supplements
Total return on the nikkei in dollars since 1974 is 3.6% annualised. So that's including exchange rate and dividends. That gets you to about double today in nominal terms what it was back then (yay compounding!) but is still a pretty terrible rate of return for having your capital tied up over a very long period of time.
Citation needed. Don't be sour that you didn't invest in at under 100.
How apropos to current events.
I am glad you mentioned Churchill here. I recently read a few biographies about him, and he appears to have had just the leadership capabilities needed to win the war, but those same leadership capabilities didn't make him as successful a leader during peacetime.
Remote Working Playbook
I would definitely set that up for some time waster sites for myself, especially if I could borrow OP's idea to adjust the delay based on progress towards other goals. In my experience, Apple's Screen Time limit is just too easy to ignore, but on the other hand I'd be worried that mucking with DNS would disrupt me when I really need to get something done urgently.
> many variables and factors also influence how things happen, but the fundamental idea that people actually do limit themselves for no good reason is also frequently seen.

There are a ton of reasons why many "average" people don't become "exceptional". But the idea that many folks make an affirmative choice not to seems pretty far down the totem pole.
Coronavirus Matters, The Stock Market Doesn’t