skysight-inc/HackerNews huggingface dataset:
> A common problem when you’re trying to transform a human stem cell into an insulin-producing beta cell — or a neuron or a heart cell —is that you also produce other cells that you don’t want

In my world this is called cancer. So yeah interesting how they're actually able to tell cells how to grow. But you don't want liver cells mixed into your pancreas, do you?

> But if a quarter of the cells you make are actually liver cells or other pancreas cells, instead of needing a billion cells, you’ll need 1.25 billion cells. It makes curing the disease 25% more difficult.

I'd assume the reason they try to get clean cultures is that otherwise they'd be implanting tumors. Optimizing by 25% sounds like something they'd do after having proven it on the human model.
Dozens of labs came up with diagnostic tests in February, but the FDA+CDC placed huge bureaucratic roadblocks.

https://www.theatlantic.com/health/archive/2020/03/why-coron...

Several states like Colorado use these alternative tests calling results 'presumptive'.
The Roche machine is a welcome addition.
Are you using Jenkins or Jenkins X for the deployment?
Huh? Both ways of typing that are completely fine. Especially since the 'correct' way of using the opposite-hand shift key is probably the worst way to type an acronym by a significant margin, since it requires so much shuffling back and forth while coordinating chorded keys.
UPS CEO stepping down [1], president of US Soccer steps down [2], Juul cofounder steps down [3].

1: https://www.usatoday.com/story/money/2020/03/12/ups-ceo-davi...

2: https://www.cnn.com/2020/03/12/us/president-of-us-soccer-ste...

3: https://www.buzzfeednews.com/article/stephaniemlee/juul-jame...
> the Voodoo magic is in the scheduling and code generation

Yes, for the code generation one needs to well understand semantics of the target language. And when it's a low-level language (Assembly), the "voodoo magic" mainly relates to generic understanding of the lower-level architectures. However, there might be compilation to another high-level language (in case of a transpiler), and by itself code generation at this stage is not that hard, simply because a target language is more understood in this case.

Instruction selection topic, and where to place the data -- on the stack, or into registers (and how a register allocator works) also mainly relates to the lower-level.

> until you get into the backend

Yes, and that's why I think it should be a separate class, specifically for higher-level compilation, and a low-level compilation.

We'll be covering this in "Essentials of Compilation".
You also get past a lot of the GDPR stuff
I agree with the article that labels are an incredible feature of Gmail, but over time I find the filter rules a bit too simply. There are certain rules that I would like to create and is not possible.
@airdeck thanks for being the #1 Creator and early adopter!
I mean like a 5 day fast to clear out the crap in your pancreas and what not. I remember reading some article on Scientfic American over 5 years ago something akin to this.
It’s worth noting that many diseases don’t converge to herd immunity except through very high vaccination rates. Examples include polio, small pox, chicken pox, etc.

So their assumption about outcome seems flawed.
Yeah, it will make Britain Great Again as it gets rid of the old population and increases its competitiveness. It almost feels natural that after getting rid of the migrants it's time to get rid of some less desired locals as well.
The impacts of Brexit are relatively abstract; COVID-19 is piles of dead bodies and 1 in 20 families losing a grandparent. Spinning that positively is mighty challenging.
How does this compare with results published by DeepMind?
I turned 31 this month, so I can say this: grow the fuck up.

If you willfully ignore science and assume that you alone can maintain your lifestyle through a global crisis, you lose your right to blame boomers for climate change.

This is our moment to show how to be different. If we fuck this up, we own whatever happens next. You selfish god damn child.
Very cool. I'd love to work with you to bring interesting apps to it.

Also, not sure if you have put much effort into trying to synch YouTube very accurately (down to the 20th of a second or better), but if that is interesting or important to you, I've done a good bit of work with dealing with the inaccuracies of YouTube's timer via the API and I'd be glad to share my code as well as ideas for this. I've found I can get it very accurate by using a bit of smoothing combined with looking at the system time. (I haven't yet done cross-internet synching and dealing with latency, but I have a plan for it)
You’re absolutely right, but larger developers and publishers have been slower to adopt.

P4’s GUI/model is also intuitive for non-programming roles to learn and use historically compared to git, so a team with wide skills can ramp up quickly with a unified toolset. A less-technical manager gets a GUI that has versioning across changes from a multidisciplinary team. You can probably guess what inertia that has in a space with higher turnover compared to other industries.

As mentioned, things are changing though. git and GitHub have become a mainstay and are what new programmers likely learn in schools. This has a trickle effect on new projects with smaller teams and results in more investment into git setups. I use git in a AAA context at work, and it’s not uncommon to find sentiments from more seasoned game programmers on git that are similar to HN comments about the latest fad in web frameworks.
Minecraft library has censored newspaper articles online
> Not really enough though, which is how they lost all the F117s over Serbia in the 90s. One of which I have a framed picture of on the wall along side an original "sorry we didnt know it was invisible" flyer. <

Only a single F117 was shot down over Serbia.

https://en.wikipedia.org/wiki/Lockheed_F-117_Nighthawk#Comba...
I read my wife the headline and we both thought of the same thing - https://www.youtube.com/watch?v=co_DNpTMKXk - which this article skips over completely. Disappointing.
Vel gert, til hamingju! / Well done, congratulations!
As far as I know, they did not communicate an overall strategy or comprehensive action plan. The basis of this thread are a series of tweets making assumptions about what the government strategy could be (given a lack of measures taken as a basis).

I do not understand how not communicating a comprehensive action plan is meant to be the harder choice ("a decision many other countries [...] not able to make") when contrasted with messures such as declaring national emergencies and widespread lockdowns of public life.
How does one detect ownership bottlenecks in Rust?
The lion's share of the test volume is done by commercial labs like LabCorp and Quest, who don't care that much about designing their own tests, they just want to maximize patient volume.

One of the companies I used to work for had a large chemistry system that could be run "open" but only a few customers used it that way, a couple research laboratories and I think a winery. Thousands of other instruments were used for plain ol' medical testing.

Even if you designed a sufficiently open system that could run Roche or Siemens reagents or whatever, any problem with the reagents and the company will just shrug and say "it's not our instrument, no guarantees."
It really depends on the type of file. ("Other large blob types" is a rather broad category.)

One obvious example where you could have a lot of common blocks (even following the offset where a change was made) is zip files. The zip format basically compresses each file individually and then concatenates all that together.

Let's say you have a build and it packages the results up as a big zip file. (Java builds often do this. A jar is a special type of zip file.) If you change a few source files and rebuild, and if your build is deterministic (and/or incremental), then the new zip file will contain a lot of the same stuff as the previous version. And if your zip archiver is deterministic (pretty safe assumption), it should produce a zip file that is mostly the same sequences of bytes as the previous zip file, even if there are changed files in the middle.

If you write a .tar.gz archive, then one change in the middle will throw everything off from that point on because it compresses the whole archive instead of individual files. In theory a binary diff can work around this by first undoing the gzip that was done to create each large blobs, then doing a binary diff on that, and then arranging to be able to recreate what gzip did. Obviously that's messy.

Of course, not every file is an archive. Some are filesystems. But any writable filesystem (notably not including ISOs) that is capable of being used on a hard disk will of necessity not rewrite everything. If it did, changing on one file on a filesystem would take hours because the rest of the partition would have to be rewritten.

Another obvious type of big blob is multimedia. I don't know a lot of specifics, but I would think file formats meant for editors would keep changes localized for reducing IO (for example, so that changes in a non-linear video editor don't need to write a giant file), but formats meant for export and delivery might change the whole file since they're aiming for small size.
There's always side effects to everything you do, but if we're being picky about the fire analogy (maybe I'd rather go to the beach than putting out a fire right now), I'd agree I should have used a gangrene one.
Let a=12 then
(a-2)^2 + (a-1)^2 + a^2 + (a+1)^2 + (a+2)^2 /365

and a binomial a+b squared yields a^2 + 2ab + b^2 so

a^2 + 4 + a^2+1 + a^2 + a^2+1 + a^2 + 4

add up all those a^2 's to get
5a^2 + 10

replace a by 12 and
720 + 10

yields 730

Divide by 365

2

That's what the sharp kid in the foreground is doing at the moment of the painting.
Buying 6 months of toilet paper is not preparing themselves to have food for 2 weeks. Your argument would be good if they were buying food, but they are not.
They are trained on a ton of non-public data though, and I’m not sure if pre-trained models are around.
Until late Feb, it was mainly CDC, but in March many more states came into the picture:

https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/test...

Depending on one's view of 'widespread' testing, we have currently about 20K tested, and around 2.4K positively diagnosed.
Or just get one of those carnival weight guessers. They get surprisingly good from practice.
Everything in moderation, including moderation.
EVs are going to be fantastic for this. Most of the buses in London are hybrids now (they have an engine, but it only charges the batteries), and it'a made them much much quieter than they used to be.
I think they’re taking more or less the right approach. I do think they could have gone further and banned big events and told anyone with cold or flu to stay at home for 7 days (instead of with specific symptoms).

It’s already too late to ban travelers, and will do more damage than benefit. Well it’s possible to score political points by closing borders, the damage it will do the economy is not necessary.

Countries like New Zealand and Israel are so isolated from their neighbors they may benefit from closed borders, but tbh it feels like more short term planning when what we need is long term thinking. What happens in 2 weeks when the crisis is still unfolding?

I wouldn’t be surprised if more cases pop up in China in new locations because of the nature of this virus (delayed feedback system)
Wow, Tomas Pueyo is a self proclaimed „growth hacker“ with no experience in epidemiology. I would prefer to have people weigh in on the issue that actually have more than two weeks experience in this. Everyone can have good ideas but giving people like Pueyo a platform for their self marketing must be an insult for all real experts that work on these issues.
I had limited luck using the provided language model, but very good results when providing my own. So if you feel the results are poor, try building your own language model.

AFAIK DeepSpeech works by using the neural net to detect characters from speech, and then the language model is used to try to make a sentence out of the character stream, by doing a kind of graph search. Thus if the language model doesn't contain the words you want it to recognize, it'll have a hard time giving good output.

Anyway, I used the following tutorial[1] as a base to build the language model. For the kenlm tools I used Ubuntu WSL, and the generate_trie executable was part of the DeepSpeech native tools package for Windows.

[1]: https://discourse.mozilla.org/t/tutorial-how-i-trained-a-spe...
I’ll take the guy who has dedicated a significant amount of his life to being an expert in the relevant area.
Cool we can build our own radar!
This startup got a meeting with Mark Suster by getting clever with Google ads
There is already a therapy that transfers beta cells from healthy people to T1 patients. The trouble is that the patients have to take immunosuppressants ever after to prevent the immune system from killing the cells off again. And I don't think that cells grown from stem cells would fare better, because it was the patients immune system that killed the beta cells in the first place.

Your typical T1 will prefer insulin therapy over immunosuppressants.
This is a great intuitive set of models. It also suggests scenarios where a poorly implemented quarantine could make things worse by intensifying contact and increasing spread between those isolated together, and then releasing everyone while still contagious. It drives home that if people are forcibly kept in close quarters for quarantine, its essential to see the full time period through. If resources might eventually wear thin enough that a quarantine may not be sustainable, it's probably better not to do it at all.
may be a conspiracy theory, but as the uk gov is injecting only 30 bil in the economy while germany is injecting 600 billion shows the uk is financially in a weak position. if the country stops working the economy is bust. the uk _needs_ to be ahead of europe to stay afloat, so that these measures as a state of war, in which economic sovereignty can be lost unless some people die on the battle front.
> Again really interesting claims you make, but please provide credible sources to back it all up.

It's called reality and human evolution. Do me a favor and find me a single vegan society that has existed anywhere on earth? You won't because a vegan diet in nature is a suicide diet.

> The Physicians Committee for Responsible Medicine[0] recommends a more plant-based diet, the opposite of what you claim

How is that the opposite? A more plant-based diet isn't a vegan diet. Otherwise, it would say an "all plant-based diet". Typical sneaky vegan m.o. I'm for eating veggies, fruits, etc. I'm also for eating meat. Because humans are omnivores and that's the best diet for humans. No amount of vegan paid propaganda sources is going to change that reality.
Happy Pi-Day!
What happens if you're not around to drive the process? What about if you don't have the organizational backing to drive the process? What if a team goes AWOL or isn't bought in to your process? I've seen variants of all those happen in production in one form or another.

At the end of the day humans make mistakes, especially when involving communication. I'd rather have a physical system that prevents breaks instead of requiring cross-team/cross-discipline coordination.

Maybe gamedev is much more coupled than film(we regularly had design, animation, art and code touching the same common core packages). Look at Unreal or any other gamedev pipeline and you'll see a bias for locking source control solutions.
There's a ton that could be done to improve this problem. If you ever want to pitch in, come join the mailing list or the Slack group.

https://groups.google.com/forum/#!forum/onebusaway-developer...

https://onebusaway.herokuapp.com
I quite like that phrase tbh! The thing is that I've met some people in my life who only did office jobs and they know nothing if it's not on a computer. People don't know how to put a nail in a wall or how to assemble a simple IKEA shelve. They get so surprised when you tell them some basic stuff that you'd think anyone should know at their age. Sometimes it gets so bad that you can't find words to describe it.
I'm not sure that having a liver cell living in the pancreas equals cancer, unless it starts replicating uncontrollably into more liver cells, and ignores normular cellular signaling.
I don't think mentioning your smart home startup in response to someone asking for recommendations for their smart home is unappreciated "corporate shilling".
You're right, the security guard is also a banker by your definition.
> It's been my breakfast for decades, I'm quite healthy, and eat a diet almost entirely composed of raw produce. The rest is nuts/seeds/legumes and canned fish.

You get virtually all of your macronutrients from the nuts, seeds, legumes and the fish - not the produce.

> I rarely ever cook, and if I didn't go for organic produce this would be a very cheap diet except for the nuts.

So it would be cheap if it was something else, but it's not.

In any event, I consider any diet high in grains/legumes a science experient which may or may not work out. I don't consider it a healthy diet.
the uk is bust - germany is injecting 600 billion in the economy, while the uk a mere 30. the uk NEEDS people to work so they keep the country afloat.
Until that response time is expected nights, weekends, holidays, and while on vacation.
That Nissan is also turbocharged, so 280 isn't the right comparsion. you should compare 400hp/1.5L to 600hp/2l. Or perhaps 500hp/2l on regular gas - either way they are similar.
The economy is a tool to get people goods and services. It is less important than life & death on a mass scale. 0.1% to 1% of the population unexpectedly dying is huge.

If the government was implementing a plan that they had considered and prepared over a number of years, carefully assessed the evidence and weighed the options? Costs and benefits have been weighed and it is hard to ask for more.

Government has no idea what is happening and it decides to go in and see how bad it is? Not a great time to prioritise the non-essential parts of the economy.
McLaren Elva (No windshield)
Sure, maybe just one week is too short and it needs to be longer. But that just makes my point stronger, doesn't it?

Using the total number of people infected today means they're including a bunch of people who may go on to die, but they're not including those deaths yet. So they're making the death rate look smaller than it is.
There are no speed limits on sidewalks, at least in my state.
Well yeah, because when we're storing structured data we don't think of that as "logging". But the point isn't to throw that information away, it's to store it properly.
There is, but there are significant barriers to entry. You sometimes see commercials for it on TV, and notice they all feature well-off 60-somethings enjoying their retirement savings and government benefits with their grandchildren. That's the target demographic for the free phone providers.

The adults I deal with have an average of a fifth-grade education. They can't fill out forms. They don't know about government programs. There is sometimes a language barrier. And to them, a phone is a precious, expensive thing and they worry that if it breaks, they'll be cut off again and owe some giant telco money that they don't have.

We have people on staff who try to help them with this sort of thing, but it's an uphill battle.
Incentives and Metrics
From the site guidelines:

> Please don't post insinuations about astroturfing, shilling, brigading, foreign agents and the like. It degrades discussion and is usually mistaken. If you're worried about abuse, email us and we'll look at the data.

Besides, the commenter was upfront about their affiliation and offered insights that appear helpful to the discussion.

From elsewhere in the site guidelines:

> Assume good faith
>Was there a reason why ML was in Florida?

They've been building pyramids in Ft. Lauderdale for a very long time.

Usually with not enough enough scale to be noticeable very far from the Everglades.
How could they understand how things work? The technology, the computer itself is hidden behind user experiences.

http://contemporary-home-computing.org/RUE/

> This approach leads to some great products on screen and IRL, but alienates as well.

> Robotics doesn’t give us a chance to fall in love with the computer if it is not anthropomorphic. Experience design prevents from thinking and valuing computers as computers, and interfaces as interfaces.

> It makes us helpless. We lose an ability to narrate ourselves and—going to a more pragmatic level—we are not able to use personal computers anymore.

> Every victory of experience design: a new product “telling the story,” or an interface meeting the “exact needs of the customer, without fuss or bother” widens the gap in between a person and a personal computer.

> The morning after “experience design:” interface-less, desposible hardware, personal hard disc shredders, primitive customization via mechanical means, rewiring, reassembling, making holes into hard disks, in order to to delete, to logout, to “view offline.”
Now that is an interesting surprise! Is that a cultural/knowledge issue, or is it poverty doing that?

In my estimation, it's just poverty. They know that other families have a phone for each person. They see the billboards, they see the TV shows, they have children who go to school with kids that have their own phones. But some of these people are working two full-time jobs, or even three part-time jobs, and still struggling.
And now more details of the plan are trickling out - over 70s being advised to stay at home (but not yet), etc.

At every point people will ask, "if cancelling large events/closing schools/WFH would have helped, why didn't you announce it weeks ago instead of now?"

Plus, it isn't as if people are actually keeping calm and carrying on. Their shopping has been disrupted, half their friends are staying home (despite no government advice to do so), they can't visit their doctors in person any more, and everybody is stuck to the news. Productivity in offices has dropped due to the anxiety and uncertainty, and I don't think Boris' "life goes on as normal for now but that may change later" speech late Friday has done anything to prevent that.
One man lost his life savings in a SIM hack
You can still today declare a function without a return value like this: "a() { return 1; }".

GCC only outputs a warning by default: "warning: return type defaults to ‘int’ [-Wimplicit-int]"
I think in terms of game production, software licensing usually isn’t the largest cost center for a project. Proprietary software isn’t a concern as much, given that games traditionally are “shipped” and then completed. (Note that this changes as games that are more online service-based with live operations, rather than a specific release date and a “final” copy sent for production; the internet has changed things a lot)

You’re more right than you think about multiple versioning systems, although keeping synchronized becomes an issue. Perforce is a bit of a boon for management, as they get a GUI for versioning across a multidisciplinary team.
You can. If you give it on a compassionate use basis to folks who are dying and if 50% more live vs. comparables then there's your study.
not sure how fragile it is, frankly logistics is very robust (and has been since the middle ages). Even with centralization it survives multiple trade wars at this moment. And it depends a lot on information tech which is also robust.
It is still linked on all of the relevant sites. https://www.gov.uk/guidance/coronavirus-covid-19-information... is a page with more frequent updates.

Specific local health authorities probably have the most up-to-date information for any given geographic area.