skysight-inc/HackerNews huggingface dataset:
So it's "locate someone by seeing what's in the background of his pictures and tweets" but make it sound sophisticated? IMINT? Geoprofiling? Pretentious much?
TL;DR for DRACOs

What it is: they made a poison which will kill a cell when two-parts of the poison touch each other in a certain way (think bubble gum in mission impossible). They've designed the parts of the poison so it should only trigger when a virus is present.

Here's why no big pharma compnay will touch it: the criterion for "virus present, KILL CELL" is potentially highly highly error prone, could easily go haywire killing all the cells.

Contrast to Immunotherapy -- the state of the art in clinically approved cancer treatments which uses the body's own immune system to selectively kill cancer cells (which also faced significant financial barriers to its development), even if the signal goes haywire, the body's immune system still has fail-safes to not killing all of its own cells.

disclaimer: i am not a biologist, but i took some basic college bio courses

From wikipedia: "Differentiation between infected and healthy cells is made primarily via the length and type of RNA transcription helices present within the cell. Most viruses produce long dsRNA helices during transcription and replication. In contrast, uninfected mammalian cells generally produce dsRNA helices of fewer than 24 base pairs during transcription. Cell death is effected via one of the last steps in the apoptosis pathway in which complexes containing intracellular apoptosis signaling molecules simultaneously bind multiple procaspases. The procaspases transactivate via cleavage, activate additional caspases in the cascade, and cleave a variety of cellular proteins, thereby killing the cell."

From the DRACO paper (http://journals.plos.org/plosone/article/asset?id=10.1371%2F...) :

"In its simplest form, a DRACO is a chimeric protein with one domain that binds to viral dsRNA and a second domain (e.g., a procaspase-binding domain or a procaspase) that induces apoptosis when two or more DRACOs crosslink on the same dsRNA. If viral dsRNA is present inside a cell, DRACOs will bind to the dsRNA and induce apoptosis of that cell. If viral dsRNA is not present inside the cell, DRACOs will not crosslink and apoptosis will not occur."
Germany is confiscating medical transports intended for other EU countries at the border.
from the FAQ:

>
How will you protect my privacy?

>We are committed to maintaining high privacy standards and keeping your data safe. Project Baseline follows federal and state regulations governing the collection and use of an individual's data, including the Health Insurance Portability and Accountability Act (HIPAA). Data is stored in advanced systems with best-in-class security and privacy protocols.

https://www.projectbaseline.com/faq/
Without work, I can’t make hours to keep my health insurance, so I’ll be forced to buy COBRA, which is just as expensive as rent.

(Or I could risk going without, while living at this continent’s ground zero for a pandemic.)

Entire industries are being shut down. There are no easy answers here.
The US is the free country, because we have no lockdown.
Those numbers are atrocious. But if SBA is offering that I wonder what small business loans from banks will look like, 1-1.5%?
I'm curious how this works in practice? Rent pays for groundskeepers, repairs and maintenance, your landlord's income, insurance, etc. Mortgages seem more straightforward. You would still owe the original amount and are likely still accruing interest.
"as well as the incubation period being so long that it’s unrealistic to contain it, is enough for me not to worry about it."

Remember that low-risk people still get infected, and still infect others. The evidence is fairly conclusive at this point that you're infections even if you lack symptoms, so you can easily be putting the at-risk people in your life (or in communities around you) in significant peril by being careless and thoughtless.

Please be extremely careful with this disease. If you're not going to self-isolate or be more cautious and normal, please do not visit any at-risk people in your life
Not sure about oxygen respirators, but some civil organizations in Hong Kong have been 3D-printing filter cans for 3M 6200 face-piece respirators since mid-February, amid shortage of surgical face masks. The designs of the filter cans are modified so that, instead of using 3M's particulate filters, one cuts a surgical face mask into many smaller pieces and inserts only one piece of them into the filter can in each use.
There may be no underlying financial issue, but percentage wise we're going down much faster. September to Oct 2008 was a 9.5% drop (steepest month drop). Past 30 days was a 20.5% drop. Tracking s&p 500.
FWIW, Ethereum WASM (ewasm) has a cost (in "particles" ("gas")) for each WebAssembly opcode. [1]

Opcode costs help to incentivize efficient code.

ewasm/design /README.md [2] links to the complete WebAssembly instruction set. [3]

[1] https://ewasm.readthedocs.io/en/mkdocs/determining_wasm_gas_...

[2] https://github.com/ewasm/design/blob/master/README.md

[3] https://webassembly.github.io/spec/core/appendix/index-instr...
Great tool for managing Kubernetes
"Your analysis is too simple.
Different consumers place different amounts of value on goods. "

My analysis is not 'too simple' because the 'averaging assumptions' I made are valid in the context of illustrating my point.

Obviously, there are 'supply and demand curves' and that everyone is going to gain different surpluses - but it doesn't matter, and just confuses the issue.

.. which is why I used an 'average consumer' with some arbitrary, made-up price points.

Your example is flawed:

"the likelihood of the product going to the consumer who values it more goes up by a lot."

This is not true, in fact, just the opposite (given the same supply/demand curves), when a middleman 'buys low and sells higher' there is definitely a lower chance that consumers will yield greater surplus on any given transaction, all things being equal.

Now - in any given random transaction, sure there will be greater/less surplus, but that's beside the point.

In fact, when the market clears fully there's a 100% chance that fewer surpluses are going to consumers with a middleman.

There is a special assumption in your example that's not overt which is 'when prices don't move' - I suppose you're hinting at a change in the demand curve, given the 'new calamity' of coronavirus. Whereas people valued Purell 'less before' and 'more now' there's the possibility that a 'middleman' has created 'value for society' by buying up Purell when the did not need it a lot, and selling it when they really did need it a lot more.

The problem with this argument is 'inventory'. There was already quite some inventory of Purell 3 weeks ago. The 'middleman buying it all' would have only decreased usage of Purell during 'nonessential' times very marginally, the overall supply really wouldn't change.

So even with a shifting demand curve, it's still no material value creation by a middleman.

If you were to expand this activity across time - for example, the US stockpiling of Oil reserves etc. - I would say this isn't really arbitrage, and the US is not acting as a 'middleman' - there are very real working capital costs involved in doing this, with measurable strategic advantages.

Finally - your note about 'queuing' is flawed as well:

"that price will mostly be made up of wasteful queuing"

No - it's not 'wasteful queuing' - they are queuing because they get better prices! They are 'playing with time' instead of 'paying with money' which is absolutely a choice many people might take, depending on how they value their time.

Again - pure arbitrage doesn't 'create value' for society, small caveats aside as illustrated in my previous note.
"There’s nothing false about it."

Actually many of the statements from your post were absolutely false.

"Fatality rate for 50 and below is a paltry 0.2%"

For a typical seasonal influenza, the fatality rate for that age bracket is around 0.01%, so this is much more lethal to those people than the flue.

https://www.businessinsider.com/coronavirus-compared-to-flu-...
This car has 3 electric motors and one of the smallest combustions engines ever in a hypercar while also running on carbon-neutral/clean fuel. Plenty of other hypercars also have electric assist and advanced engine management that gets them higher fuel efficiency and lower emissions than your average family SUV. Your concern is entirely misplaced.

Also you should focus on industrial uses like container ships and coal power plants that create 1000x more pollution if you're really that serious about it. The world is moving as fast as it can, but oil is used for more than just transportation and it's not changing overnight.
Helicopter money to small businesses.
Virtual Religion in Iran
Faced with public pressure, Iran's clerics acquiesce to holding virtual prayer meetings. https://en.radiofarda.com/a/iran-second-largest-city-at-risk-of-coronavirus-disaster-/30487795.html
Not exactly a prediction market in the strict sense, since there's no buying or selling. It instead uses internet karma points.
Lives and dollars are not totally different things. How many lives will be ruined by total financial destruction? How many will commit suicide in the months and years after due to financial issues?
Oregon announcement expected Monday: https://www.oregonlive.com/coronavirus/2020/03/oregon-gov-ka...
What would be a reputable source for education? I've been reading reports from the CDC and the WHO, as well as listening to microbiologists I know personally who have been studying coronaviruses for some time. I'm seeing lots of fear here, but nothing concrete. Please, educate me: what am I missing in my information feed?
The federal government regulates firearms under the commerce clause the same whey they regulate pharmaceuticals under the commerce clause. The difference is they can outright prohibit marijuana and not rifles because the latter prohibition would violate the second amendment.

The commerce clause doesn't override the second amendment (or any other part of the bill of rights), there are only cases where a particular amendment was found not to apply.

What you're looking for is emergency powers, but they're not actually in the constitution. In practice what has happened is that Presidents do whatever thing in an emergency and then get sued over it after, and typically lose, but by then it's years later and whatever temporary measures they ordered in the middle of the emergency are long since discontinued.

It's kind of a kludge, but it also kind of works, because it keeps the emergency measures from extending longer than it takes for the courts to catch up to it, and also gives the victims of rights violations the ability to get compensated after the fact for being done wrong in the midst of a big mess.
So I'm getting down votes because the post I'm replying to changed the link from https://en.wikipedia.org/wiki/Classical_period_(music)

On that page the second sentence is "For an article about Western art music from the middle ages to the contemporary era, see Classical music", and Classical Music links to https://en.wikipedia.org/wiki/Classical_music
The depth and breadth of topics and examples is amazing. Well done!

My only nitpick would be the formatting of some of the equations. Instead of

$$ E = hf $$
$$ E = (6.626 \times 10^{-34})(10^{9}) $$
$$ E = 6.626 \times 10^{-25} \, \mathrm{J}$$

I think it would be clearer to use

$$\begin{aligned}
E &= hf \\
&= (6.626 \times 10^{-34})(10^{9}) \\
&= 6.626 \times 10^{-25} \, \mathrm{J}
\end{aligned}$$

which is the KaTeX-recommended approach for emulating \begin{align} ... \end{align}.

I would also throw in a word or two of explanations in there, so it's not just equations, e.g., explain "Using the formula for the energy of a photon, we find: <eqns>". I guess it would end up being more work for you, but would be worth it for the benefit of students learning that it's not just about the numbers, but knowing what you're doing (like you do in the strategy sections).

On the other hand the current format of line-by-line-show-only-the-equation-steps is very practical too --- from my experience certain students prefer to see just the practical steps they have to do on the exam, rather than the blah blha blah around them, even if it can be educational.

It would be interesting to see some of the questions/examples converted into self-test quizzes. Show a few examples, then ask readers to solve some problems on their own. I know the idea is they will try to solve on their own an only reveal the solution after they've tried, but realistically speaking more likely they will click that arrow ;) So maybe just a delay to force them to try?

This is getting into the realm of the fancy, but you could maybe make the reading with a "customizable difficulty level." Beginner = info (maybe hides certain more advanced topics), all questions solved as examples. Intermediate = some questions solved as examples, but missing final steps so reader has to complete them to get the final answer. Advanced = most examples show as quiz questions reader has to solve on their own...
There are far bigger things to worry about than a limited run hypercar from a boutique manufacturer that uses the smallest gas engine, advanced engine management, and 3 electric motors to improve fuel efficiency and exhaust vastly beyond your typical family car.
IIRC, most Kiosk machines have physical buttons for accessibility purposes. You could use that interface as opposed to the touchscreen (be sure to sanitize the buttons first).
We already have these limitations in place now don't we? I mean we can't go into private property, because it's someone else's property. Your right to swing your fist ends where my nose begins kind of deal.

If you're free to move around while sick, doesn't that in essence limit my freedom to go to the same place? If you're infected you are in fact a danger to those around you.
If he'd stockpiled a year ago, it wouldn't have been in a state of emergency for one. If he still gouged after the declaration of a state of emergency though, he'd still be liable for breaking the law.

It is not that hard to be a responsible member of society and to not jeopardize the well being of widespread geographical areas in the hopes of profiting off a crisis.
It does infect cats, dogs, and bats (at least). And it seems money/interest was the problem:

https://www.nbcnews.com/health/health-care/scientists-were-c...
Why does it take 4 seconds to load each page? Is that just me?
> I looked for "HIPAA" and didn't find it anywhere.

There is an on page link to the applicable privacy policy: https://www.projectbaseline.com/covid-19-privacy/
At least in California, there will be guidance about evictions and the plan is to provide housing for all 108,000 homeless people. Italy has frozen many financial/property/contractual relations and it's likely that this will spread to other jurisdictions.
It's a limited-run hypercar capable of 250mph+. Weight makes a massive difference in performance and effiency.
They had 1700 engineers working on it, what'd you expect?
But it does sound like if there's priority and fear, much time could be saved. For example, "6 months to recruit 1000 people". I suspect in this case, a week can work.

> Then you need to analyze all the data you collected, so another 3 months.

Help me understand this. You vaccinate 1000 people. In 6 months, the number of them that get sick is 10% of the rate of the unvaccinated. 0.1% have a bad reaction. How much more analysis do you need?

> the FDA takes 3 months to review and approve

How much time if that is moved to the front of the queue and all hands work on it? Given how enormously disruptive the coronavirus is, we cannot afford to not have all hands working on it.
> No precedent for it, and a lot of Supreme Court precedent against it

Could you cite some of that precedent? When I did my research around quarantines, the things I found said that precedent was very thin. What precedent there was typically was extremely deferential to government responses during emergencies and pandemic outbreaks.

I didn't find any SCOTUS cases myself, so I would be very curious to read the SCOTUS precedent against it.
reedx8's post is about reedx8's level of worry and personal risk assessment, which is 100% about reedx8.
It’s more OK, because the pool of customers is constantly rotating while the pool of line cooks is mostly static. Incidental contact from picking up food is much less infectious than breathing the same air for an hour.
A license needed for delivery/takeout? How is that justified?
We've banned this account for repeatedly spreading flamewar on HN. Could you please stop creating accounts to break the site guidelines with?

https://news.ycombinator.com/newsguidelines.html
Note that this text only appears under "How will you protect my privacy" _under the FAQ page_. If you look at the question with the same title on the landing page, HIPAA is not mentioned
No, people stockpile bottled water in emergencies with the assumption that it will NOT be easy to replace, i.e., the tap might stop releasing water.

I've seen way too many comments like "Why would you need bottled water in a pandemic?" with the assumption that municipal water systems won't fail.

My (US) small town's municipal water system fails a couple of times a year in the best of circumstances, usually just resulting in a "boil order" for a few hours until repairs are made.

But imagine half of our six water filtration workers are home sick or caretaking family, or the trucks that bring the spare parts are sitting idle at a depot four states away. Now our town needs 4000 gallons a day just for human survival.

To finish the thought experiment, note that there are over 150,000 water distribution systems in the United States.
MA: https://www.nbcboston.com/news/local/26-new-coronavirus-case...
> Why develop (...)

To get more research, obviously.

Also - epidemics are tail risks. You cannot just leave them to the market to be priced on the expected value basis, that will leave them grossly underpriced.
That's the general project baseline FAQ, the COVID-19 project FAQ has a similar question which does not address HIPAA: “We are committed to maintaining high privacy standards and keeping your data safe. Project Baseline follows federal and state regulations governing the collection and use of an individual's data. Data is stored in advanced systems with security and privacy protocols.”
Noting that the comment you are replying to has changed the link from https://en.wikipedia.org/wiki/Classical_period_(music), presumably because that page points out that "Classical music" includes music from the Baroque period as well as the Classical period.
For some reason, the text under https://www.projectbaseline.com/faq/ is different than that on the COVID-19 page. The FAQ page does explicitly mention HIPAA compliance
Well the (in my opinion flawed) idea is to remove the incentive for buying that much in the first place.

Say what you want, but someone receiving this enormous an amount of social shaming on top of a painful economic loss, sure is going to disincentivise people from pulling similar stunts in the future.
I'm going to go ahead and call you a cynic here.

Do you really think there's any way that the State of Washington will be permanently banning events over 50 people?

Do you really think there's any way that the State of Washington will be permanently preventing the operation of bars, dine-in restaurants, and entertainment facilities?

I'm generally pretty skeptical of creeping government powers myself, but this just...doesn't seem like a place where the government is going to keep these things shut down permanently. Which of these enacted bans are you concerned about becoming permanent?
You might want to reference what actually causes the most pollution. Massive container ships, coal power plants, and manufacturing facilities make consumer ICE vehicles insignificant in pollution potential.
This is good. You can find in this thread that other states are following the suit. This might, just might if we're lucky, that the curve will start becoming quadratic and then logarithmic.
That's because one is about Project Baseline in general (the one that mentions HIPAA) and one is about the special COVID-19 project (the one that does not.) They are different FAQs about different efforts.
>On December 16, a one-month suspension of the vaccination program is announced by CDC head Sencer. William Foege of the CDC estimates that the incidence of Guillain-Barré is four times higher in vaccinated people than in those not receiving the swine flu vaccine.

The rushed vaccine apparently substantially increased the risk of Guillain-Barré syndrome in those receiving it. The syndrome is fatal in up to 5% of those that contract it and can cause permanent damage to the peripheral nervous system.

First, do no harm.
Creditors can experience some of the pain that they normally inflict on others. They are not sacrosanct and are the least important parties in economic relations during an emergency. As normality is restored, they will have new opportunities during the ensuing large scale financial restructuring.
Becaue gold (and silver) is the Constitutionally mandated legal tender the US dollar is supposed to be based on, and it was still true when the Model T got started.

That's the exact form of compensation, whether wages or bonus, that American wage earners had simply been working for up until that time.

There was extreme ambition for gold in particular continuously since before ancient Roman times, and few substitutes had yet been well accepted.

The degree of undue trust in politicians as beneficial economic influencers was not as strangling.

Some American workers actually often earned decent amounts of gold while others worldwide usually earned much less or none for similar effort.
I’ve been using Infra.app for over 3 weeks. Love it.
Made by the founders of Kitematic and Docker for Mac and Windows.
Their care shows in the product.
Uh well it causes bilateral interstitial pneumonia which is inflammation that causes irreversible scarring around the air sacs. If you get it you will have scarring. If you get it badly you will have bad scarring that will impact your future health. If you have an underlying health problem esp if it involves your respiratory system you are fucked. Combine all of this with thousands of your neighbors Unable to breath creates a very interesting union in the ER.

Maybe the Wikipedia article on bilateral interstitial pneumonia will change your mind?
What an excellent resource!

https://landgreen.github.io/physics/notes/relativity/special...

The speed of the photons from the headlights on a moving vehicle is not `velocity_of_vehicle + speed_of_light` (`v+c`) !? Anywhere?
Because despite using the Project Baseline webpage, the Verily COVID-19 effort is distinct from Project Baseline and operates under different processes, probably.
I remembered your comment today because we had a doctor call our pharmacy to order +1000 hydroxichloroquine tablets for everybody in his assisted living facility, requiring 12 tablets per patient for prophylactic use. Our Pharmacist in charge referred him to literature and informed him they would need an Rx for each patient even if we had that kind of supply, but overall this was not an appropriate practice without a full list of all medications that patients are currently taking. Anyway I thought you'd find this interesting.
It's probably not worth having a big thread about one use of the word "may", especially since there is a flood of this kind of story right now. On HN, there's no harm in waiting until a thing actually happens, and an announcement of the possibility of a future announcement is off topic.

https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu...

https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu...

(I don't have any information about this, having just read about it here like everyone else.)