skysight-inc/HackerNews huggingface dataset:
+1 the major advantage of RT-qPCR is it's a massively amplified test. Tiny amounts of virus can be detected. When you're detecting a patient's antibodies to the virus, the patient is producing massive amounts of it. That said, after clearing the infection that production will decline, but still should be detectable at least for a while.

Direct detection of viral particles is substantially harder because for N viral particles you basically get O(N) signal (to put it in CS terms). There are some caveats, your readout antibody can generate an exponential signal for example.

You still need to be presenting the right part of the capsid and have the right material. In the direct ELISA scenario, you need 2 antibodies. One to bind the capsid to your surface, the other to bind it again and either have a readout attached directly or be bound by yet another antibody with the readout (likely the latter). Fortunately, viral capsids are repetitive so you might be able to use the same antibody for both. You ALSO need those antibodies to have low cross-reactivity with sputum or whatever other rough sample you have. When you are looking for a patient's antibodies, the patient's immune system has already taken care of that for you. This is all tricky, obviously it's not THAT hard, but it's not trivial.

RT-qPCR is directly a O(2^N) signal. It's extremely sensitive, requires very little assay development, can be made very specific, can work with little sample prep, so it's a much better front-line, first-to-go test than direct ELISA. Still, we'd all love an ELISA, particularly to patient antibodies.
That may not go on forever.

If Euro governments want to do something real about antitrust, this would be a good place to start.
South Korea has done a good job of getting enough tests done to have meaningful data
Same in Bangkok, for what it’s worth, with Tesco deliveries
Good time to be a gamer.
One edge case to consider.

If you have stocks in a pre-tax retirement account like a traditional IRA in the US (or RRSP in Canada?), now could be a good time to sell them, move the money into a post-tax account like a ROTH IRA (or TFSA?), then buy the equivalent number of stocks there.

You will pay reduced taxes because the value of the stocks is relatively low, then pay no tax when you finally withdraw from the ROTH. (All else being equal and imho, the market is likely to recover over time)

That is, if you don't mind the risk that the market might massively rebound in the middle of the transaction.

There are a bunch of assumptions here. Do your own research and don't blindly believe a stranger on the Internet. Make sure you understand the taxes, fees, penalties, or whatever you will have to pay.
> Python, Ruby, and Perl

Oh, the irony! If the FBI released a lineup of suspects in the case of who killed Unix, those three names would be right at the top, with Perl as the ringleader* .

Besides, Unix isn't Perl, Python or Ruby. It's an OS turned API in the form of POSIX. BeOS was Posix compliant and could build and run Unix software. Even plan 9 can build Unix software using APE, the ANSI Posix Environment. Apple just doesn't feel like paying distro package maintainer.

* See #8: https://interviews.slashdot.org/story/04/10/18/1153211/rob-p...
These Norwegian ones are temporary and surrounded by a lot of regulation. Effectively the employer doesn’t provide any tasks nor any pay, but doesn’t end the employment. It’s a suspension of employment rather than an ending. Such a suspension obviously only has any meaning in a situation where being employed actually brings security. For example, the company can’t hire other people.
A netsplit still allows you to moan about it in company. I consider that an advantage over discord's "oops sorry".
Why, exactly?

If you have a healthy emergency fund in cash to cover your liabilities for 6 months (or even 1 year to be more conservative in this environment), what is the problem in throwing every bit of cash that comes your way (paycheck savings, ...) and you won't need for a few years, at the stock market as it goes down? Over decades the stock market has had an IRR or 8%+, and that IRR includes crashes like these.
Kyoto Protocol vs. Paris Agreement: Key Differences to Know
I have no bitcoin and would never give one red cent to the shabby, frequently fraudulent outfits that call themselves exchanges in order to obtain any.

You have fun now with all that name dropping. The track record of cryptocurrencies so far has quite thoroughly shown me and most of the world AFAICT that those points are a bust. It's worse than the systems we already have, in pretty much every way.

I note you don't actually address the points made either.
These goddamn liberals have gone too far this time.
The biggest one being that's it's available on xp, vista and 7. Had they back ported WinUI to at least 7 it wouldn't have been dead on arrival.
Fears and thoughts like that (and that yolo redesign of MacBooks) made me switch to Linux on Dell p5540 for work.
Questions about Covid-19 from different cities around the world
Ask HN: Can aquarium UV lights be used to kill coronavirus?
The below paper suggests that with approx 2.4mWsec/cm2 it's possible to inactivate 99% of viruses. No specific mention of coronavirus, but could we use 13W aquarium UV lamps (are they UVC?) for an effective solution?

https://www.researchgate.net/profile/Chun_Chieh_Tseng/publication/239392662_Inactivation_of_Virus-Containing_Aerosols_by_Ultraviolet_Germicidal_Irradiation/links/54f823b80cf2ccffe9dce501/Inactivation-of-Virus-Containing-Aerosols-by-Ultraviolet-Germicidal-Irradiation.pdf
IIRC PS4 relies upon (Free?)BSD, because of the permissive license, and there are probably other widely-used devices that do the same, so I'd imagine lots of people have a BSD or two in their home and don't even know it.
Coronavirus Live Updates
I think it's been for a while that "unix" == "linux". How many people install gnu tools on their macs using homebrew?
Do you have links to solid evidence? I saw an article from an expert (I'm blanking on the specific article right now) that other "cov" viruses are known to have a limited immunity that lasts for possibly several weeks or so.
message needed in this time. Please don't think about money in times like this. we need each other and we are all in this together. stay safe and let other's be safe too.
The trouble is not that he incidentally commits them. He simply has no idea what they are.
Ask HN: Kubernetes applicable to what domains?Web Infra, ML(Kubeflow)?What else?
I like Linux's decentralized approach.

That would work for Npm.
Npm has enough problems that its worth running your own mirror for business continuity.

Microsoft are likely to make breaking changes immediatly.
SF Bicycle Coalition is suggesting that it's fine:
https://twitter.com/sfbike/status/1239658920718643200
Microsoft has been firing UI, data access, etc. toolkits at people for the past 30 years.
Every 10 or 15 years there's an actually important one that people will end up using. You can't always know which one straight away, but basically that's Win32+MFC and then WinForms for GUI. And Qt, although that's not from MS.
It's possible that in a post-Catalina Mac world, Unix scripting languages -- at least the ones currently included with the system, e.g., Ruby, Python, Perl -- that Apple will use the same mechanism that they currently use for git and some XCode-specific command line utilities: when you type the command, you'll be told the application isn't installed and it'll offer to download it for you.

Even if that doesn't come to pass, I'm not super concerned about this. Which isn't to say that I'm serenely unconcerned, but as people have noted, there are ways to install and manage these without them being provided by the OS vendor, and probably most Mac users here have been doing just that for a long time.
Yes, it could. There is a hypothetical "stuck network" situation, but that really is dependent on a lot of network power disappearing. Before that you'd end up with a lot of idle hash power and ex-miners wondering what they could achieve in the way of an attack with it...
Here is my personal checklist:

* If in a loosely typed language go way out of your way to ensure conventions are in place to identify things by data type. TypeScript has completely changed how I look at JavaScript particularly its use of interfaces for defining objects and data structures.

* Limit your use of dependencies as much as possible. In my current personal project I am down to 1 dependency. Dependencies will weigh a project down and prevent nimble shifts of direction. This also includes frameworks and tools.

* Write good documentation and keep it up to date. Automate the authoring of documentation where you can so that it stays up to date with less manual intervention.

* Isolate concerns as much as possible so that a feature can be deleted and replaced with as little effort as possible.

* Keep things simple. This requires lots of extra effort both in planning and refactoring. When there are fewer pieces and everything is as uniform or consistent change requires far less effort and leaves far less dead code in its place.

* Don't abstract things for convenience or easiness. Abstractions are incredibly helpful when they result in simplicity (fewer pieces and fewer ways of doing things). Absolutely don't use abstractions as a means of being clever or for vanity reasons. Then you just have extra code and the larger a project gets the harder it is test and change.

* When other people want to impose their opinions on you push back until they come back with test automation and/or strong provable evidence of a better way of doing things. If they still try to impose their opinions on you, and this will happen, kindly tell them to go fuck themselves. So much of the stupidity in programming comes from baseless irrational subjectivity.

* Test automation. Its not about how you test, but about what you test. There is a lot of nonsense out there about how to test. In my current personal project I have automation in place for code validation, compile checks, command tests in the terminal, service tests. Soon, as I figure it out, I will be adding test automation for user interaction and user data storage. However you are able to execute all the kinds of tests you need just do it. The goal is to promise your software can deliver a feature and prove it with test automation and then add more tests later to cover for edge cases you did not consider.
How is OSX more unix-like than Linux?
By certification: https://en.wikipedia.org/wiki/Single_UNIX_Specification#macO...

FWIW, I think "Unix" as a philosophy exists (even mainly exists) outside the spec certification, but this is how you get there.
While eating a banana should most certainly not result in a banana-grease coat on your vocal cords, it will be all over your throat. Might just be a little bit like hand lotion for it.
Remote work: Microsoft Teams is experiencing some outages
This feels mixed. If true, it is more than just explaining how rapidly it spread, as the spread happened months ago. It also raises the question of why is it so severe some places, but less so many others?
Even with the same fare class, the tickets sometimes cost more through the change interface on United.com. We've added more detail to our post-- https://bookwithcarry.com/blog/united-cheap-flights-coronavi...

I can assure you that there was no intentional fudging here, and if there's something we're missing, we'd be the first that would like to know it. Due to all the discussion about fare classes, we've also included information in the blog post about problems in the change flow related to that.
GNU's Not Unix!
I think this is highly likely, actually, considering the verbiage that Apple uses to refer to these.
https://www.monterail.com/blog/famous-companies-using-elixir
Yes, this! I wouldn't be happy as a shareholder if this happened but if the last resort for a company is a government bailout the government should own the company and benefit from the recovery.
> this novel flu

COVID-19 is as much a flu as you are a fish. Probably less so.
Nope, because hacker news wants to believe that capitalists are adding more value than they take out.
True, the draft is not an ideal example. None the less, the court is hardly infallible: for example, it is odd that congress can not constitutionally require medical insurance but can institute taxes and even prohibit the consumption of anything deemed to be an intoxicant.

Or for more specific examples, given, Gore v Bush, when exactly does the court have standing to intervene in a presidential election? Given DC v. Heller in 2008, what does the word "militia" mean now? Why, to everyone's surprise, did maritime law suddenly limit punitive damages with Exxon vs Baker (2008)? Why did the court narrowly reverse 200 years of convention and the near universal understating of speech with Citizens United?
I use MacOS heavily for command-line heavy programming work

> Future versions of macOS won’t include scripting language runtimes by default, and might require you to install additional packages.

This sounds sensible to me. For ruby, python, node etc you need specific versions for different projects. I literally never use the OS's python -- that's a private matter for the OS and if it doesn't need Python any longer then fine. (rbenv, pyenv, nvm etc help with managing versions)

> What bothers me the most though is that Apple has removed the man pages from their online documentation.

I recommend installing the coreutils package from Homebrew and using that over the BSD Unix utilities.

I also (perhaps controversially?) would recommend using --help over man pages where possible for the simple reason that you are probably fallible, like me! Us mere mortals tend not to have a clue whether the man pages we're looking at are for the executable we're invoking or not, and staying on top of man pages involve staying on top of a bunch of environment variables and weird directories that date back to the hairier days of UNIX. With foo --help, you are always 100% sure that it is giving help for what the executable "foo" resolved to.
That's a retro thinking back to the era of the bond vigilantes. That's gone. There's so much stuatory purchases of t-bills that will outweigh any inflationary pressure from QE4. The demand for t-bills was almost insatiable _before_ this mess. Now, it's even more.

T-bills will do just fine despite any outward appearances of inflation. BTW, would rather load up on real estate than "precious" metals. Gold is a relic from a bygone era.
Patient 31 was told to take a test despite not meeting the criteria because her doctors had a hunch, as I understand it.
tru but at least if you search discord delete on github the top result is a pretty thorough script that nukes ur history
Citing testing after the CDC's failed initial test reagents is not painting a whole picture of care capability. The testing will catch up in the US. What isn't easy to scale is the critical care of patients who are hardest hit. That is a capability which the US excels in:

[1] USA has 34.7 ICU Beds / 100K
[2] Canada has 9.5 ICU Beds / 100K

[1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351597/
[2]: https://www.researchgate.net/publication/275101876_Critical_...
Correct. Let's wait and see where the path of least resistance takes us. It goes somewhere from the commercial paper market to anyone levered, all the usual TBTF suspects.
Fundamental to the Green New Deal is a program to create new jobs in the green sector, so we can get off fossil fuels without creating massive unemployment and hardship. This is what makes it reminiscent of the new deal. This is essential to making a politically and economically viable proposal and makes it a climate justice proposal rather than just a climate proposal.

What we have so far, is cutting fossil fuels without any of the support to prevent this from hurting those who are already struggling. It does give the earth a break, at least, but we need the other stuff to help people and make the change stick.
So put some aside like a real business, for unexpected contingencies.
Does this mean the mortality rate is, approximately, 10x less than currently estimated?

(86% of cases unreported, eg about 1 in 10 reported, assume that number of unreported fatal cases is 0)

Edit: closer reading suggests the optimism is sadly unwarranted, the headline under-reporting number of 86% is from the early pre-travel ban model, post-travel-ban estimates give a 65% detection rate, combined with the increased number of cases in this later period this implies that naive mortality estimates are more like 2x off than 10x off.
Because macOS is literally certified BSD UNIX.
> * I don't think there's anything about the term "server" that implies independence.*

Communication is perception.

Simian above, and myself grew up in an era where a server did indeed imply independence. Counterstrike servers, IRC servers, FTP servers, all independent things in these contexts.

For others the perception may be different as I assume it is with anyone young who primarily encounters the word server in their Discord use.
I don't see how anyone could find issue with that rule against political cartoons mocking people. If you don't respect someone, that doesn't give you the right to mock them. Take for instance Singapore, Singapore does not allow mocking or political cartoons of their public officials. Not only does this maintain a civil air around politics, it stops it degrading into a mainstream popularity contest. With the side effect that Singapore politicians are actually able to be seen as a respected figure.
Because GNU is not Unix
You also need universal mask wearing. South Korea had a huge cluster, but mask wearing practice saved it from spiraling out of control.
Amazon is! https://aws.amazon.com/jp/blogs/opensource/aws-sponsorship-o...
The Seattle flu study is an example of what you want.

As https://komonews.com/news/coronavirus/seattle-flu-study-alle... shows, the USA was refusing to test Americans in Seattle while COVID-19 was actually spreading. When the Seattle flu study tested they found that it had already been locally spreading for weeks. And in fact most people who think that they have COVID-19 in the USA are unable to verify whether or not they have it.
Which package manager has the scale of JS and isn't hosted by a commercial entity?
The estimates that I've seen have ranged from 330k to 10 million deaths in the US.. and that's just directly from COVID-19 alone.

An overwhelmed health care system and lack of medicines and medical supplies is likely to cause even more deaths.

That's not to mention other possible deaths due to the ensuing chaos and social and economic disruption brought about by the above deaths, global political instability, and reduced supply and demand from the rest of the world as it battles this pandemic.
So you expect the EU to force Apple to write software for another platform?
The article said the patient showed signs of recovery and then later on started showing signs of the virus again. I don't know if that means they conducted an exit test to confirm that she was negative for coronavirus after her first bout with it. Maybe it died down in her system, but wasn't completely gone when she was deemed healthy again and later on it flared up again for some reason.
If you're looking for a unix-based OS on which to develop software, and want a slick GUI on top of it for browsing the web, I encourage you to consider Chrome OS.

It is extremely secure, easy to use, and simple, and has allowed me to develop software on it like it is a linux machine.
That's the principle, but it doesn't reflect to the reality around us, or at least my reality.

I am in the tourism industry, owning a small-medium hotel.

If I stop paying any loans and generally I am left out of cash-flow I am pretty much screwed for the next few years, if not closing down.

I know though a few people around my area with massive resorts and a debt over 100mil that have already stopped paying quite a few loans themselvs and they are getting away with a slap on their wrist. The gov gets involved cause the debt is enough to damage a bank, and the people that are going to be left without a job are enough to cause a mini crisis. Then the bank itself... well for them its not just about ceasing the asset as its gonna be a hard thing to sell or manage.

Meanwhile the owners are taking out massive salaries + bonuses for their personal accounts and don't care about their balance sheet being a mess and their debts growing.
Except it's not, and the US is the literally best equipped to minimize fatalities: https://cdn.statcdn.com/Infographic/images/normal/21105.jpeg
Just go in and use hand sanitizer + wipes at the pump. No need to make it complicated.
Name 5.

Yes a "server" especially if you call it "my server" implies some sort of independence.
Well there’s nothing stopping you or me from picking a BSD and donating to the project monthly. It’s not the same as install base but probably way more important to them.

At this point the endpoint sphere is in transition. Someone could take a BSD and launch the next big thing on it if they had the right killer app. Netflix is a good example of this, or which ever consoles have ran BSD, too. I’d love to make my own startup with embedded or modded *bsd as well someday.
Not bothered at all, I never had any reason to believe it was a private system.
> inevitable for vehicles that carry cargo

But not for a vehicle that carries one person
And not just that. They're going to be tracking all these kids who are going to miss months of school as a big "natural experiment". Who knows how many other things they'll be able to get data on... Very sad times, but hopefully people can learn a few things while we're at it.
I really need a good track pad, on par with Macbooks. Any recommendations?
Unfortunately (or fortunately because other phenomena are based on this also -- see gossiping protocols), that is true. Once you have a critical population, related with the connectivity of the subgraph, the propagation is self-sustained, that is everyone is going to get infected in a SIR model or similar. One could argue that you might change the curve slope a bit. And I guess that is the bet here.
In the minds of people opposed to controlling CO2 emissions, your comment here justifies all of their worst fears of CO2 emission regulation as a means of social control.
to all those who are blackhat , this is not the time to commit crimes and give people reason to want to dissconnect services, if you are a criminal at least realize that you are overtaxing your bread and butter.
give it a break for a while until the system can handle the load of light and dark together
And audio.
I think this one is more about demand than supply. White-collar workers are of course being productive from home, but even manual work - in an employer-controlled environment - could conceivably be made safe. Amazon just announced that they plan to hire 100k warehouse and delivery workers.

Public spaces on the other hand (retail, restaurants/bars, travel destinations), are just totally infeasible to make safe until things are fully over with. That's a serious cut to demand that just has to be waited-out.
When Coronavirus Turns Every Sports Channel into ESPN Classic
Self selecting tests. Need the types of control data that polling companies use.
Eh.. there won’t be. But it’s not because of some altruistic motivations, it’s bad PR and the sheer numbers of lost customers would out weight the benefit of terminating for non-pay.
People don't buy bonds for yield any more.