skysight-inc/HackerNews huggingface dataset:
Northern Italy here, we're entering the third week of school closure. We have a platform that is usually used by teachers to record marks and other communications to parents, and they're using it to put homework. But it's barely an hour of work everyday and only ensuring that the kids do not forget the last things they did in class. They will not manage to finish all topics for their grade.
The FDA should not require efficacy testing. If it’s safe let patients and their doctors do what they want. In practice that’s what they do anyway, see off label prescribing which is around one fifth of all prescriptions in the US. Removing efficacy testing would double or more the number of new drugs available.

Fraud is already illegal. Doctors can already be sued for malpractice. Testing for efficacy makes no sense in a world in which off label prescribing is routine.

> Assessing the FDA via the
Anomaly of Off-Label Drug
Prescribing
—————— ——————

> Once a drug has been approved for some use, the FDA has almost no control over how that drug is actually prescribed. The prescribing of drugs for non-FDA-approved uses, called “off-label prescribing,” is widespread. Drugs prescribed off-label have not met the FDA’s requirements for proving efficacy in the off-label applications. The practice of off-label prescribing therefore raises interesting questions. Why does the FDA, in effect, require that some drugs be tested for efficacy but not others?
If there are good reasons for the FDA to have strong pre-approval powers regarding efficacy, shouldn’t FDA post-approval powers be commensurate? Alternatively, if there is good reason for widespread off-label prescribing, doesn’t this call into question the FDA’s pre-approval powers?

https://www.independent.org/publications/tir/article.asp?id=...

> There are also scientific reasons to replace Phase 3. The reasoning behind the Phase 3 requirement — that the average efficacy of a drug is relevant to an individual patient — flies in the face of what we now know about drug responsiveness. Very few drugs are effective in all individuals. In fact, most are not effective in large portions of the population, for reasons that we are just beginning to understand.

> It’s much easier to get approval for drugs that are marginally effective in, say, half the population than drugs that are very effective in a small fraction of patients. This statistical barrier discourages the pharmaceutical industry from even beginning to attack diseases, such as Parkinson’s, that are likely to have several subtypes, each of which may respond to a different drug. These drugs are the underappreciated casualties of the Phase 3 requirement; they will never be developed because the risk of failure at Phase 3 is simply too great.

http://www.washingtonpost.com/wp-dyn/articles/A43257-2003Nov...
Invite Anyone to Your Shared Web Experience with a QR Code/URL
For the innocent, being falsely accused sure is scary. The consequences of being wrongly declared guilty, or even just accused, can be severe.
Porn, gore, and gambling habits aired in Virgin Media breach
Show HN: Privacy focused infrastructure for your web app
I don’t know enough about this space to parse this article without lots of effort - what is the current state of the art for solar cell efficiency and how scalable is the manufacturing process? Is the printable part the significant advancement?
And there have been no deaths or major riots since the ban, perhaps this was an effective way to control the situation during the change of guard. Now it's back to normal and the Kashmir economy is right on track, integrating with the rest of India.
A Transactional Memory System for Parallel Python
> If you actually had any inkling of which way the markets would move... you'd be retired already.

Yeah, this is exactly what my sane, smarter wife says. I briefly worked in a startup that built tools for professionals in the finance world. What I mostly learned there was that I knew nothing.
Indeed. I would like to see further reading on the methodology of adjusting your spend to maintain adequate levels of conversion while hitting your budget.

Of course, many agencies can quite quickly find places to spend money beyond AdSense :)
Really, you're going to use a logarithm because it fits one data point better?

Besides you might as well just use all your datapoints directly. There's no real need to interpolate between them (and if you really want to optimize your ad costs that finely, don't use a function that predicts -infinty gross profit if you don't use ads).
> Intel processors are supported for production workloads. Support for AMD and Arm processors is in developer preview.

Firecracker looks very promising from a server-side technology stand-point but the support for AMD, RISC-V platforms couldn't be stressed more enough.

Amazon better find a way of supporting AMD processors since Intel's CPU bugs are being brought into the sunlight and exploited in all directions by security researchers which have cataclysmic implications for users and server providers these days. This is demonstrated by a ridiculous Intel vulnerability which rendered Apple's FileVault encryption facilities completely useless which is absolutely unacceptable to Apple. There are many other CPU vulnerabilities waiting to be found and it could be the next Meltdown-like candidate.

The sooner the move to AMD or RISC-V open technologies, the better for developers and users.
> school staff trend older and are at highest risk.

This part doesn't sound right -- the highest risk groups are 70+ years old. Hopefully the school staff retires before then. The mortality rate for people below 60 is only around 1%.

The worry with young kids is that they may still be able to spread it, putting e.g. their grandparents at huge risk.
I wasn't a good self-directed learner until my late 30s :P Good luck with the remote schooling! Part of the world's biggest remote work experiment.
It's sneak, he's always complains about things like this in, at least my opinion, overly dramatic fashion[1][2].

[1] https://sneak.berlin/20190929/keybase-backdoor/

[2] response from keybase https://github.com/keybase/client/issues/20022#issuecomment-...
Paper here:

https://bitbucket.org/pypy/extradoc/src/extradoc/talk/dls201...

(Click on "View raw")
This might run afoul of the Carpenter decision, right? It basically held that asking for cell tower location data is a search of the person rather than a subpoena of records.

EDIT: maybe not. This one had a warrant rather than a subpoena. I'd still be interested in the interaction though.
Yeah I had that though while writing up my first follow up, but the compositing here is between multiple, small endpoints and GraphQL is subsetting one large endpoint.

Maybe you could model kernel calls as a single large subsystem that allows multiple questions, but GraphQL seems a lot less imperative that syscalls so I’m having trouble picturing how that would translate.
This is a good point, and you're right that some brands work this way.

I've worked agency and in-house, and most of time I've worked without budgets, just trying to maximise volume at a particular CPA. More brands are moving this way, but a few do still just stick to fixed budgets.
Polichombr: Collaborative Malware Analysis Framework
better link. sorry > https://www.nytimes.com/2020/03/06/world/middleeast/saudi-ro...
It would be nice if every JS statement had an expression equivalent.
advertising the benefits of seatbelts has saved thousands of lives.
That's just a visual filter (DOM level). uMatrix and uBlock lists block network requests.
>Virgin Media said in a post that unauthorized access was to a marketing database that included “limited contact information such as names, home and email addresses, and phone numbers” for about 900,000 subscribers.

If I have your name, address, email, & phone number, my efforts to contact you won't be "limited" in any way.
So marginal revenue = marginal costs, aka Econ 101 lecture 1?
State’s predicament in Flint is how to dispose of 76,000 bottles of water
My sister is a lawyer who works with poor clients with criminal cases (though not a defense attorney). She believes strongly that most people are better off with their public defender than with private council. I asked her if she could square this with the general perception that the criminal justice system is stacked for with wealthy, she answered that the, most of the time, the connections matter more than the actual money. There are a lot of bad private lawyers out there, and it's hard for most people to tell them apart from the good ones. For a lot of us here, if we suddenly need a lawyer, then we'll ask our friends and family to help us find a good one. But if you don't know anybody who knows anybody who knows a lawyer, what do you do? Look at online reviews? If I were freaked out about criminal charges, needed a lawyer now, and didn't have my connections, it'd be up to blind luck. That's the reality for most criminal defendants.

They'll hire private council and think that because they're paying for it, it's better. But it's often not. For a typical defendant with an aggravated assault charge, a public defender has handled dozens of similar cases before. Moreover, they'll have done it with your judge and your prosecutor. A private lawyer probably won't have that. Granted, this probably holds a lot less for the HN comments section.

I'll add that there is no right to defense council for civil cases. These can have consequences just as dire as a criminal case, as in immigration or eviction proceedings. An indigent defendant with no lawyer has a very poor chance. There's a movement to create this right [1]. The current Supreme Court, however, seems more likely to weaken Gideon v. Wainwright than expand it.
I doubt better surveillance tools will lead to more accurate prosecutions unless individuals also have direct access to the tools.

Police and prosecutors in the US are notorious for leaving out evidence that exonerates the accused, even though they are supposedly required to provide the defense with all evidence relevant to the case.

Also, well-connected victims’ cases are investigated much more carefully than normal victims.

For instance, some SFO luggage handlers were stealing stuff from bags. People repeatedly reported them to the police, but nothing happened until they stole from a retired cop. An investigation was launched and they were arrested the next week.

Similarly (based on personal experience with multiple incidents in multiple cities with multiple victims), they normally won’t bother to pull location database records for successful burglaries, even if they have exact timestamps of the incident (up to and including video), even in remote areas in the middle of the night involving literal truckloads of loot (where the location records would be a slam dunk, and the evidence would take a while to dispose of).
This is a decent article explaining how things have gone wrong in various ways:

https://www.washingtonpost.com/health/what-went-wrong-with-t...
From your links I guess you're in the UK, in which case check out the Monevator site. It's UK specific financial advice, with an emphasis on FIRE.
I am no expert on the subject, so please bear with me if I am missing something. But it looks like back then, people really believed the invisible hand will take care of things, and it didn't, and I would be surprised if it does in our case.

From Wikipedia:

The new Whig administration, influenced by the doctrine of laissez-faire,[11] believed that the market would provide the food needed, and they refused to intervene against food exports to England, then halted the previous government's food and relief works, leaving many hundreds of thousands of people without any work, money, or food.

Charles Trevelyan, who was in charge of the administration of government relief, limited the Government's food aid programme because of a firm belief in laissez-faire.[98]
That really leaves the random victim out to dry. You cant get that kind of money out of most shoplifters no matter how hard you sue them. Would you hold this same position if it was your house the police bombed?
I think you wholly misunderstand that the fingerprint is randomized on every restart of the browser.

That is so much noise that it renders fingerprinting as a strategy utterly useless.
SWAT are trained and equipped to do a siege. Cut off the utilities. Wait it out. What's the guy going to do?

If you read the articles, yes, it was triggered from a shoplifting incident.
Australian Associated Press announces closure
Firstly, I'm 100% against torture and agree its ineffective. But your rejection of the logic here is incorrect.

> In this situation there's no reason the person isn't going to lie for an extended period of time about A, B, C and D. So why wouldn't they then lie about E?

You seem to be thinking about this in chronological sequence, as if we ask about A then B then C then D then E. If that was the case, then yes, your logic would work. They might have lied about A for a long time, then B for a long time, then C for a long time, then D for a long time, then E for a long time and you'd never know if they were telling the truth about E.

But that's not what is being proposed. We ask about A, B, C, D, and E altogether. As in you have conversation and asked them about A, B, C, D, and E before doing any torture. If they lied about A, B, C, or D we torture them. Then we have the same conversation again, and torture them again. Eventually, they start telling the truth about say C. Why C? They are just choosing something at random to tell truth about in hopes of making the pain stop. But nothing changes, we keep torturing them because we know they are still lying about A, B, and D. Eventually they also start telling the truth about A, then E, then B, then D. Then we stop torturing them because they are being honest about everything we can verify. They can escape without divulging the information only if they keep E until last.

The key assumption here is that the person being tortured reveals the truth in a random order. It is improbable that they happen to keep the one thing we cannot verify until the end.

This is not to say that this procedure would be effective, but its not ineffective for the reason you suggest.

On the theory side, the probability of keeping E until the end is 1/5, which isn't that low.

On the practical side, this requires that the person being tortured has no idea what you can and can't verify. If, instead, they have some idea of what you can and can't verify, they'll be able to keep the hardest to verify information till the end preventing this scheme from working.
Show HN: Karaoke for any song in any language
Relatedly it was announced today that a faculty member at the Stanford school of Medicine tested positive:

https://www.ktvu.com/news/stanford-educator-tests-positive-f...
Not to mention that they have armored vehicles and so forth.
Trying to "explain" things to the police is a very bad idea:

https://www.latimes.com/opinion/op-ed/la-oe-duane-dont-talk-...
I think you’re confusing monopolistic behavior with unethical behavior. As the parent said, the existence of a strong (larger!) competitor means Wal-Mart isn’t a monopoly. My local Wal-Mart has a Super Target and Kroger right across the street, for goodness sakes. It’s not a monopoly.

Undoubtedly, and the examples are numerous, Wal-Mart has used its market position to exploit its suppliers and to use their suppliers to creatively sell their own products.

But these scenarios aren’t the product of Wal-Mart exercising monopoly power, but rather exploiting those suppliers who violate rule #1 of manufacturing: don’t be dependent upon a single customer or that customer effectively owns you.
Awesome.

"Our error is not anthropomorphism, but the opposite. We refuse to believe, to the point of absurdity that we and they are first animals, that there is no us and them in this regard, only us, all of us."

I raise chickens (and various other animals) and more and more this is exactly how I feel. All higher lifeforms (and I don't care to speculate where "higher" ends) are conscious, and all conscious life is essentially alike... there is "I" and the "the other" and we all have desires and fears and relationships and curiosity. What else is there to life?
That means one of two things; the slots aren’t worth that much or they were sold for less than they were worth. If they’re almost worthless, as not using them suggests their not being used is no great loss. If they are worthwhile then either they’ll be used, someone else will buy them or the owner is setting money on fire by not using a valuable asset, in much the same way as someone who uses a vacant lot in Manhattan as a planning lot instead of building a skyscraper on it.

If you want a slot to go to its most valuable use sell it to the entity that values it most, whether permanently or by auctioning it yearly.
Yes, you can install uMatrix, and it works normally. Writing from one.
Lets be real here. They didn't track his bike. They tracked his phone. Your phone is how you are tracked.

It doesn't matter if you're using an application where you didn't read the TOS and opted in or what. The basestations are always going to be collecting years of aggregate multilateration data on your habits of movement and saving it.
US police can rape women on the job and walk with a suspended sentence: https://www.elpasotimes.com/story/news/crime/2020/01/31/-/46...

That shapes the culture. It's kind of anti-Spiderman. With great powers comes no responsibility at all.
Hasn't happened here yet. The issue in the US will be dual income families where mom or dad HAVE TO GO to their pleace of work. This is going to make a mess for many, many families.
We did some remote learning out here (Gwinnett county - north of Atlanta) during weather closures. The software was awful and crashed the first day under high load.

They used it again during a single day closure and the software worked fine that time. However, many students didn’t do it, opting instead to play in the snow. Or, some children had to go to day care since their parents weren’t staying home. When they returned to school the teachers just repeated the same lesson since not every one was on the same page.

I think remote learning is possible, but we are a far way from having the kinks worked out.
Am I missing something? If you take your license plate off your car, you will be pulled over by a cop. It's not practical for most people in the U.S. to give up driving.
I heard a presentation on Jini when it was young and this something they very much wanted to do, but I believe it got watered down to mostly sending code from the server to the client and not so much the other way around.

This is reminding me of a research hardware project from the same era where they took NUMA design about as far as you could go; they embedded simple (vector?) computing directly onto the RAM chips, so the code goes to the data instead of the other way around. One of their demos was splitting the screen up into cells and calculating pixels in parallel directly on the memory chips.
There was an old ax they used instead. Its head periodically flung off, each time narrowly missing someone.

Perhaps before someone gets killed or maimed, we can learn how to hammer a wedge into an axe handle.

It’s a mentality that I have difficulty grasping. That doesn’t make it bad, I just fail to “get it” (and I spend plenty of time in the woods). For example, the angst of not having a cell connection: that tells me this isn’t aimed at me. But it also says some folks have a need for such programs.
There are plenty of teachers in their 60s, where the death rate is 3.6%. If 30 teachers in their 60s get it, one of them will die on average. Even for people in their 50s the rate is still 1.3%, huge compared to the flu.
Pretty certain he described his generalized perception - I doubt he'd stand by it as an absolute.
Ok but let's be honest: Unix is at it's core still a teletype emulator no matter where you use it. It's the central metaphor for the system.
There Are 2 Seats Left for This Trip to the International Space Station
They announced today that a faculty member of the Stanford School of Medicine tested positive:

https://www.ktvu.com/news/stanford-educator-tests-positive-f...

Don’t have the link on hand but there was a study floating around showing something like a 10x difference in impact for every week early a school closes during a virus outbreak. Seems pretty obvious that closing before a positive case, at which point the cat is kind of out of the bag, is much better than reacting. Especially in the situation we’re in now where the trend is obvious.
Kids are at lowest risk of serious infection [...]

Also kids might get infected and infect other members of their household.
Depends. Farmers can't live with that illusion, they prefer something they can fix themselves (that is a recurring topic on HN.). It's possible more enterprises will end up like that as the current wave of outsourcing everything will ebb.
It doesn't solve the problems that led to the embrace of inflationary currencies at all. These are among others price inelasticity and the very powerful psychological "number going up is good" factor.

Try explaining to an employee that their paycheck is smaller because currency has appreciated in value, or to a bank that the principal of a loan should be written down for the same reason. "But number go down bad!"

Inflation hides these things. It's a hack around these problems.
> Bonds are almost like a future of expected return on capital.

I would argue this is true for all investments that are judged by their ability to make money.
Are Apple products any safer on this issue, or not at all?
For the love of God why does TechCrunch hijack the browser back button.
The Dutch and German, Van, von, de, Vanders of the world comiserate.

jVM :)
Healthy soils lead to healthy food and added value for all
The mysterious case of the unexplained downloads spike
News PDF Online – Download All Indian Newspapers
Something tells me that if the end of the world comes, this sort of article will be a moot point. The Earth just can’t handle that many subsistence farmers and hunter/gatherer types. So most of us won’t make it.

Besides that, this is a strangely American fixation. You never seem to hear about doomsday sort of things in the same vein from Europe’s news outlets. China’s culture has endured the collapse of centralized authority many times over (most recently in the 19th and 20th centuries). Western Europe eventually came back from the collapse of the Roman Empire. If things really fell apart in North America, you can bet that the EU and China would figure out a deal to maintain some semblance of stability near the coasts, for the sake of protecting economic interests.
The App That Reveals Who’s Tracking You on Your iPhone
For casual users, out of the box experience - the default - is way more important. I can not recommend Firefox for my relatives. Brave I can and I do.
You don't own your license plate.
The world doesn’t owe you compensation for every bad thing that happens to you.
If it were (literally) "the complete end of the world", I don't think you'd need to prepare -- I mean, I know this is just semantics, but the end would be just that.

And I get that's not what the article is actually saying, but the title is very clickbaity.
Wow, this is so inspiring.

I’m a lot younger, but this is something I’m going to try to remember and keep in mind going forward.

My aim is to be creative and productive through my nineties, to the age of 100.
I don’t think I was meant to get a giggle out of this. Can you explain using other words? Of course a painted surface isn’t bare. It’s got paint on it.

Did you mean it’s not aluminum? Or a different grade?
Real: software development.
Parasitic: everything else.
He didn't have to fight them getting his location data. It was a choice he made.
My bad, it did not break records outside the 1987, dot-com and GCF crises, made a mistake there. However, I don't agree with the theory of infinite economy growth (as you said "constantly be broken in the future").