skysight-inc/HackerNews huggingface dataset:
What these measures seem to overlook is that there have been cases where people looked and felt fully healthy, didn't have fever or cough symptoms, but still had the virus in their blood.

As such, quarantining only the people that are visibly sick is not enough to prevent the virus from spreading.
Clair Cameron Patterson
I half agree and half disagree.

I’m assuming that by architecture you’re referring to system/enterprise architecture and not eg CPU architecture. For a given system, the viable solution space is massive, and the decision on which approach to use is a mixture of science (analyzing and meeting numerically-defined requirements), art (meeting soft requirements), politics (making everyone happy about the unquantifiable choices), and taste (choosing between different similar solutions when no other constraints makes one better than the other). Two organizations facing the exact same problem can come up with two vastly different solutions that both effectively solve the same problem.

How those decisions get made is, I believe, an extraordinarily interesting social sciences question!

There are huge seats of computer science that do, to me, fall under the umbrella of “hard science”, but not all of it. Philosophy, taste, and social dynamics play a huge role in “industrial computer engineering”, and to try to pretend that’s not the case is setting ourselves up for failure.
Yep thanks for pointing that out! It's the last of 3 main topics in the post
I've got a teenager. This is very, very not the case.
20 years ago before digital cameras were useful (they existed but where poor quality) all pictures were by film which was somewhat expensive if you took a lot of pictures. (figure $.75/picture) It made sense to take care to get each picture perfectly posed as if anything was wrong it cost money. Now when have digital cameras where the marginal cost of each photo is 0.

People have adjusted to free photos by taking more. However they have forgotten that they should also adjust by not spending as much time to pose perfection and instead just get the moment.
Am I missing something here?

"On the surface, vast quantities of hydrocarbons in solid and liquid form lie ready to be used for energy. Although the atmosphere lacks oxygen, water ice just below the surface could be used to provide oxygen for breathing and to combust hydrocarbons as fuel." [my emphasis.]

They are proposing splitting water to get oxygen for burning hydrocarbons to produce energy - but splitting water itself takes a lot of energy, and low-entropy energy at that. Could this process possibly result in a net increase in useful energy?
You just wrote 500 words that firmly establish that DNSSEC is controlled by world governments, and concluded as if you'd said something else. Wild.
But the title sounds better that way. Why resort to calm, fact base reporting when clickbaiting is the alternative?
What specific measures have they taken in South Korea? It seems to have been fairly effective. Lots of tests is the thing I know about. What else?
Worker safety net measures get attention as coronavirus outbreak grinds on
Open-Floor Offices Could Help Spread Coronavirus
... after I turned on translate, and clicked on "Accept" (Akzeptieren).
SARS-CoV-2 is the later, official name of 2019-nCoV.
“Bad faith” research might be more appropriate, since it sort of acknowledges bias
Interesting about the meal storage - what are the arrangements that places like Italy are making for food distribution?
Disingenuous effort.
Do capitalist organisations not have a vested interest in lying about socialism?

It's very frustrating that the economic system that vastly improved the material condition of my ancestors is casually slandered by Westerners. Capitalism was imposed on Eastern Europe and now my country is worse off than when my parents were my age. Capitalism is only good for the exploiter, but a disaster for the exploited.
Sounds like you are mistaking gallows humor for sincere intent. I've heard the same jokes but I'm 100% sure none of the people making them actually intend to spread disease.
No idea. Only other context I've come across this as a lay person is in describing gain of function research.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996883/

Not sure that's what the other intended though, would appreciate someone with technical understanding interpreting.
A Peek Into Graviton2
It should also be a law that customers can not be opted-in by default, or through consent buried in a 100 page TOS agreement. There should be a requirement that the question is presented to the user in a clear way.
All true, it is also to buy time to develop medicine. Every month we can push the worst cases into the future the more likely we have an efficient response.
Nope, that won't work. Facebook will ask you for a phone number and for a selfie. It will then match both against their databases, and ask you for an ID if there is none.

You can get a "burner" phone number and even a physical phone (that's what I do for whatsapp), but you can't have a burner face to make selfies.

...so now I don't have a FB account at all, and it is very inconvenient.
> In Poland most shops allows you to scan and pay for products in matter of seconds without any help. No lines, no hassle.

In my part of the US this is common as well, but there's almost always a line to use the scanners that is about the same as the line for the a human checkout clerk. So I almost always opt for the human.
Fast and early compared to whom? We knew it was coming and it seems like we’re still making preparations and only started after we unloaded a ship of sick passengers without proper planning.
You'd need a lot of monoliths.
Couldn't agree more. Open default links in separate container + delete all data from this container would make the desktop experience like Focus on mobile.
Detroit is right next to Lake St. Clair and Detroit River.
I know someone that had the bright idea of watering his garden by taking water directly from Lake St. Clair. He bought a large 3x3 foot plastic water container, put it on the back of his the truck. When he tried to fill it up, got stopped by the Police. What's the legality of taking water directly from the Lake?

Living off the land, is not really an option if its illegal to take water. And outside of the mountain regions, very little public land. Not that you could take trees from public land either.
What happens to your brain on the way to Mars
I have worked a lot of jobs before I got into sent where that was the expectation. Being sick was a matter of “pushing through” and “not being a burden”
Having negative numbers for when water is in a different state is quite a convenient representation, especially for weather. To follow your scale, -50ºC is really cold (polar weather) and +50 is really hot (desert weather). Yes there are places hotter and colder but it's a continuum with convenient points that stick out less than a phase change of the liquid which is so integral to life, be it human, fauna or flora.
Looks like it can reconcile this automatically.

https://keepass.info/help/v2/sync.html

Probably better used with a filesystem that has strong guarantees though.
Super Bernie World
That's a very confusing page layout with not so good news design. I'm sure the content must be nice, but I couldn't focus at all.
It's not the experiment that was dishonest, though - it's drawing conclusions from it as if it was conducted correctly that's dishonest.
Might be in a somewhat jokey fashion, at work I've already heard some jokes in the region of "corona will take care of the last-time voters" (Letztwähler, German word that inverts 'first-time voter')
Show HN: GitHub Action to enforce minimum review times
Helping local small businesses through the impacts of Covid-19
Right, the desktop GPUs have support for float64, but it's not exposed in HLSL/GLSL to the best of my knowledge. "precision highp float" in GLSL will get you 32-bit on all vendors AFAIK, you have to use OpenCL/CUDA for 64-bit floats, but it's way slower and actually sometimes emulated.

None of the mobile GPU vendors (Apple, ARM Mali, Qualcomm, PVR, BroadCom) support it. You can see that here, where the only vendors supporting shaderFloat64 in Vulkan are desktop GPUs. http://vulkan.gpuinfo.org/listdevicescoverage.php?feature=sh...
If the alternative is being slowly eaten by the beast....
> Medicare could also be expanded slightly to automatically cover an annual physical and age based cancer screenings.

It doesn't even have to be Medicare. Just give everyone a $100 voucher for a physical every year and let them take it to any licensed physician. Then there will be some who do it for the $100, others who charge $120 but maybe it's worth the extra $20 from your HSA because it's 3 miles out of your way instead of 30 (and has to charge more because real estate costs more there).

The way Medicare "negotiates" prices involves a lot of wrangling and distortion and politics. Vouchers solve the same problem while still allowing people to choose to pay a little more for something they find to be worth a little more.
You should use this: https://pleasantsolutions.com/passwordserver
I could imagine that not causing symptoms would probably be ideal if the virus could survive endlessly and not get eventually killed by our immune system.

But anything that does get killed by our immune system is kind of on the clock and needs to spread relatively quickly.
Sure, but chroma is absolute in LCh, which makes it hard to use for color generation. 100% chroma in HSLuv is the highest value of a particular hue in LCh.
Carne Asada and Forms: Why Quality Matters for Both
1) Slow, confusing and rarely updated (any any updates are just as likely to be a regression as an improvement in my subjective opinion) UI. The browser extension is terrible and up to last year, their hacky password-field-finding javascript slowed down several pages to to point it was unusable. It's still not great.

2) The business model of LastPass worries me. Unlike a 1Password (I tried it for a 3 month trial, don't use them or have any skin in the game for them) charges a lot more than LastPass and in addition to having a more smooth, speedy and performant application, they are charging enough money to feasibly be profitable just storing passwords.

LastPass has has more data breaches than the others (google). It's run by a domain register. In my opinion this influences how the password business is run, leading to a marketing-forward rent extraction password manager vs a good one.
You can totally design a CLI around that kind of data model without resorting to jq
My wife and I watch Price is Right... our favorites when they describe the car is the paint and fabric protection. Also, a few weeks ago, they had one of the Canam trikes - it had reverse!
Buried underneath this discussion is a lesson in incentives.
A Peek into Graviton2: Amazon's Neoverse N1 Server Chip First Impressions
This is awesome for students from poorer districts who have no access to the internet when COVID-19 keeps them from school. A fairly good move for education equality. Besides, it would be better if free (cheap) tablets are also offered.
> But I wonder: why has China succeeded in (maybe only temporarily) stopping and reversing the exponential growth?

I heard rumors that Chinese doctors got quotas of max cases they can report, then they have to make something else up.

Plus all other stuff that they enforce there, like mass spraying, presonal lockdowns etc. That must play role too.

Problem with China is that you can never trust what they report, as they are not allowing any outside org in to check /help/advice.
Some proteins are inactive first after they have been synthesized. Furin is an enzyme that targets certain sites in certain biomolecules and cuts a piece off, activating these proteins. Apparently some furin is floating around in the human body for this purpose. The article suggest that there is a furin target site (binding site) in the surface "spikes" of the coronavirus. And when furin cuts piece off the spikes, the resulting, or remaining, part then assists the entry of the virus into cells.

Here is a review article from 2019 on furin. Apparently several viruses use this "trick" as part of their entry mechanism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682551/

(I have some biology studies from long ago, I am not professional in molecular biology.)
"Beat them to this concept"? I can't even remember the first time I heard about this idea. 2003? 1995? I half-suspect I read about the idea in OMNI Magazine.

It's always been a question of when the supporting technology was going to be good enough to make it work. The idea has been around long enough for most of the early patents to expire.
I think the POTUS should be held to a higher standard than this meme tier tweets. But hey, it have been almost 4 years, I guess we should be used to.
Plain English Overview of Machine Learning and Deep Learning
I hope your wrong. That the spread is somewhat contained and that a vaccine is developed before 2.5% of us die.

But I hope that someone in government is thinking like this and taking actions accordingly.

Being pessimistic isn't and overshooting your precautions is probably smarter than thinking we are going to have a "cure" in a few weeks, like POTUS said.
Robinhood’s third outage may point to deeper problems in its tech stack
The cleavage site is the target that gets cleaved, not the part that does the cutting. So in this case the virus has a site that can be cleaved by certain enzymes like Furin.
Show HN: Donttouchface.com – Uses ML to notify you when you touch your face
Yes, and here is a good overview of it in the context of some contentious research [1].

[1] https://journals.sagepub.com/doi/abs/10.1177/030631271666642...
From the Wiki page for Furin

> ...must be cleaved by furin or furin-like proteases to become fully functional. Anthrax toxin, pseudomonas exotoxin, and papillomaviruses must be processed by furin during their initial entry into host cells.

From the sound of this:

- the site on the virus gets cleaved
- Furin enables the cleaving
- Furin exists in hosts cells

What I think I understand is, the cleaving makes it easier for the virus to reproduce inside the cell?

edit: turns out I have no idea how to format things on HN
What does LCS stand for? low carb sugar?

one more q, is the insulin spike level of fake sugar similar to that of a regular sugar?
It is. The consent has to be explicit and informed.
When will world governments finally admit we are dealing with a bio weapon engineered in a lab by a rogue group or nation.
An idiot’s guide to animation compression
Agreed it's not a trivial problem. That was my point, that we need to show the cases of worst behavior often, loudly, and broadly so that people are informed and have the option to make choices.

Got a bone to pick about BG, gotcha.
This is the best informational page layout that I've seen in a while. Many products/services would benefit from following suit.
It's funny that the old point-and-shoot film cameras everyone used in the 80s and 90s were perhaps the best way to actually capture what's going on rather than turning a photo into a big production.

You'd hold the camera in your right hand and prepare for the picture by cranking the film with your thumb. When you wanted the picture, you'd quickly raise it to your eye and take the shot. There was no waiting for focus, because they were all set to infinity focus. They used simple analog light sensors to set the exposure the instant you pointed the camera.

With a phone, you might raise it to your face so FaceID will unlock it, then you look for and open the camera app, then you're using both hands to hold the phone out in front of you and wait while it focuses and figures out exposure; if you're using a cheaper phone, this could be several seconds. Then you take the picture and, again, if you're not using the freshest iPhone it might take 1-2 seconds between tapping the shutter button and actually being sure the picture has been taken. It's intrusive and slow.

Photos from my childhood often feature me either looking at something else or having just turned my head to look at the camera because my mom called to me. Photos today often seem to have a more posed and unnatural feel to them, because it's difficult to take a good picture stealthily; "hang on, I'm going to take a picture" is the common refrain.
EEStor was lying through there teeth and never allowed anyone outside the company to directly measure ED, just gamable proxies for ED (such as capacitance).
> I have tried to recruit too many smart people who are wasting their prime years of productivity working in Big Tech because ‘the pay is too good’.

This is the most honest sentence in the entire piece: We should remove the choice of individuals to work at Big Tech Cos because I want them to work on something else for less money. This whole essay is embarrassing for Chamath.

Edit: Almost unbelievably, he closes with this: "Take the advice of others but carefully consider how it applies to you. What works for others may not work for you."

Also can't help but laugh that he compares Social Capital performance to Berkshire. Social Capital outperformed the S&P by 19%, BH by 155%
Everyone is wearing a mask, whether or not they are showing symptoms. SK gov has a mask delivery program through the post office. This helps limit the spread. While the US gov tells everyone to not wear a mask, unless they are showing symptoms.
Apple is pushing back on that wording. https://github.com/gpuweb/gpuweb/issues/582
tl;dr any unique feature of this virus may be explanatory for its demonstrably increased virulence, and may be targetable by existing therapeutics as well. This particular feature is a candidate finding of this type — the specific molecular biology involved isn't particularly important for non-molecular biologists (I was one in a past life).
https://eur-lex.europa.eu/legal-content/EN/TXT/?qid=15288746...

Article 7 is the key bit, specifically entry 2: "...the request for consent shall be presented in a manner which is clearly distinguishable from the other matters, in an intelligible and easily accessible form, using clear and plain language."

(edited to remove superfluous GDPR reference)
Markets look a bit better today, because hope springs eternal
I guess following a link that goes to a different container will break session cookies, and such, which for some/most is going to be annoying.
Fair point, I am sure they have people much smarter than me in charge of making decisions like that. I am purely speculating at this point but that route could also lead to just being dragged out (if the offer was made public).

There might be a lot of reasons, and I am sure there would have weighed all their options and gone with this decision.
A Doctor's Life on Coronavirus Front Lines- If We Fail, What Happens to You All?
I'm not sure why this is circulating HN.

Most of us here are not medical or epidemiological experts at all, and most of the comments here are just people asking for an layman's explanation of this paper. Trying to ascribe meaning to highly technical results seems futile (at best) or irresponsible (at worst).
Appears to mean Low Calorie Sweetener
Great comment. Real life is HD as fuck!
oh right that makes more sense thanks!
> I always end up feeling ... could have been done ...

Stop it. Stop it. Anyone can feel that about anything, anywhere, and at any time, and it's only destructive.

Yesterday is history,

tomorrow is a mystery,

and today is a gift...

that's why they call it present

---

I mean, it's good you want to do better. So, do better.
Just a couple of years ago, Google was one of the major tech companies who were strenuously defending the use of third-party cookies. They're shifting to eliminating them (someday) solely because they were forced to. The other major browsers were committed to doing it, and it became clear that this could pose a threat to the dominance of Chrome if Chrome didn't follow suit.

But at the same time, Google (as well as the rest of the marketing industry) is working on replacing the functionality of third party cookies without having to use them -- thus negating the entire reason to restrict third party cookies.
I did not know that, nor do I have dogs - but might have one again in the future. Thanks for the note.
I like the terraforming idea better, and we could get it started with todays technology, it would just be really expensive - simply build a bunch of solar shade cells and assemble them in L1 orbit between Venus and the Sun, and keep expanding the network until you cover Venus in night. Then let the planet cool for a couple hundred years - a lot of that thick sulphuric atmosphere might solidify and fall to the ground and get the atmosphere down to workable levels.
I came to read the comments to find out what this means.
Is there anyone who can translate this into something more understandable?
Of course they can, but this is just click bait is my point.
This particular study though doesn't have any impact on how we personally react to the virus though, so it falls into the realm of intellectually stimulating.
As I just replied to a sibling comment, I'm not sure this is entirely true. If I look at old pictures my parents took on film, a lot of them are frivolous and unposed--and enjoyable, because they're not a row of people standing with picture-smiles on. The pictures were expensive, but the attitude to taking pictures was also different. You'll find out if the picture was good in a couple weeks; no sense taking another.
Indeed: https://en.wikipedia.org/wiki/Furin
> If the underlying premise is flawed, who cares if the methodology is correct?

The post you're replying to includes an explanation addressing that point.
there is a protien on the virus that is called S [spike].

there is a protien [protease] in the extracellular space of your tissues that cleaves other protiens these are called Furins.

Furins activate enzymes where they are needed by cleaving [cutting away all the shipping wrap].

The S protien of the nCoV SARS 2 virus has a cleavage site that is cut by the furin class of protiens.

this seems to be a modification as the SARS CoV does not have this cleavage site as far as can be seen for the time.

so what does this do?

the S protien is specific to a binding site [ACE2] and that will be found in high prevalence in the lungs, but is found elsewhere. the corona virus does not seem to shed through the skin but through mucous and sputum so the virus that is efficient at lung infection will win when this is its transmission mode.

if the virus doesnt make it to the lungs it is in a less than optimal place for survival compared to the lungs.

so the virus has a specific tag recognition sequence to find ACE2 and stick.

this is where the Furin comes in. The S protien is in shipping state until it reaches the lungs and is cleaved by Furin, this is when the S protien become S1; S2.

the S1 stays bound to ACE2, the S2 does some work and wrenches the cell membrane open then inserts its nucleocapsid---this is now an infection.

the exact details are not entirely worked out such as is there an absolute requirement for S binding or S cleavage in any particular order. and does anything else participate in the process.

the authour suggests some correlation of furin cleavage sites with increased pathogenicity [potential to cause disease] based on observations of other unrelated virus having a newly acquired cleavage site correlated with increased proclivity to cause a disease process in humans.

there may be some undercurrent regarding these molecular feature as a general theme in biology, however there is not a firm scientific consensus that this is the case.

the articel referenced is a preproof meaning it is close to being accepted for publishing so it isnt science yet.

[PDF] here :

https://sci-hub.se/10.1016/j.antiviral.2020.104742
I don't see how closing airports and highways would be a Constitutional issue. Of course curtailing travel wouldn't stop travel, but it would sure slow it down.
Everything is O(1) when you have finite bounded input.