skysight-inc/HackerNews huggingface dataset:
Not a biologist, but reading the paper, the chain of reasoning appears to be summarized in this section:

> Taken together, the neuroinvasive propensity has been demonstrated as a common feature of CoVs. In light of the high similarity between SARS-CoV and SARS-CoV2, it is quite likely that SARS-CoV-2 also possesses a similar potential. Based on an epidemiological survey on COVID-19, the median time from the first symptom to dyspnea was 5.0 days, to hospital admission was 7.0 days, and to the intensive care was 8.0 days 15. Therefore, the latency period is enough for the virus to
enter and destroy the medullary neurons. As a matter of fact, it has been reported that some patients infected with SARS-CoV-2 did show neurologic signs such as headache (about 8%), nausea and vomiting (1%).

There's also this rather disquieting anecdote used as evidence of a link to the nervous system:

> According to the complaints of a survivor, the medical graduate student (24 years old) from Wuhan University, she
must stay awake and breathe consciously and actively during the intensive care. She said that if she fell asleep, she might die because she had lost her natural breath.

Supposing that this neurological link is real,

> the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral [sic?] or conjunctival route will be lighter than those infected intranasally. The possible neuroinvasion of SARS-CoV-2 may also partially explain why some patients developed respiratory failure, while others not. It is very possible that most of the persons in Wuhan, who were the first exposed to this previously unknown virus, did not have any protective measure, so that the critical patients is much more in Wuhan than in other cities in China.

So let me ask a dumb question for someone with actual biomedical knowledge. Are they saying that infection of the CNS is somehow easier through the nose, in which case high-quality face masks actually do matter?

I'm also confused by this sentence in the introduction, which appears to contradict the hypothesis that the upper respiratory tract is a high-impact area?

> However, different from SARS-CoV, SARS-CoV-2-infected patients rarely showed prominent upper respiratory tract signs
and symptoms, indicating that the target cells of SARS-CoV-2 may be located in the lower airway.

I will note that, unlike some other papers on this topic, this one has been peer-reviewed in what seems to be a legitimate medical journal (Journal of Medical Virology), so there should be some genuine substance here.
What to Do If Your Team Becomes Distributed Overnight in Response to Coronavirus
It looks like CDC recommends to use them for ≤ 8 hours (continuous or intermittent) [0].

[0] https://www.cdc.gov/niosh/topics/hcwcontrols/recommendedguid...
I don't need to memorize anything. Information I use on a daily basis is easily recalled. Information I use infrequently can be looked up on my phone.

Spaced repetition might help if I was studying for a test or preparing for a game show.
I completely agree that revenue gets too much airtime, at the expense of profit. I do think revenue can be a useful stat for startups, for example if it is a harbinger of future profit. Imagine you're spending $500k/yr on engineering to build a platform, and you're bringing in $500k/yr in revenue. In the early years, this means you have no profit. But if your product (perhaps Saas?) is one that requires much less upkeep than initial development, then you can be fairly certain that your business will become profitable once the early dev work has been completed.

Of course, you can't be naive here and forget to account for customer service, maintenance, etc., which all ramp up over time.
Not much different as weed being illegal in The Netherlands but the government is looking the other way and condoning it.
There's evidence coming out that ADHD is at least correlated childhood trauma, so it's possible trauma causes ADHD: https://www.ncbi.nlm.nih.gov/pubmed/28477799
Let your kid play and be patient
Any example of that?
Simulate to a certain extent I think yes, emulate, obviously no, but in the simulation extremely critical discoveries would be lost that only appear in a full emulation. Simple distinction maybe, but worth noting I think.
I will admit that I too was worried about net neutrality as being one of the downfalls of the web. But I do feel like the conversation has shifted to Google, Facebook, Twitter, and Reddit, etc having such dominant positions and that they can influence even political outcomes, pick winners and losers, etc. The web needs more competition.
of course there is, it's just a lesser cost than the cost of approving bad ones
Perhaps. But

a) apparently branch prediction is good enough to make all this constant checking for exceptional returns to slow down the execution by only a couple of percents;

b) apparently exception propagation and re-throwing is way, way faster than in the standard implementation;

c) the exclusion of the unwind tables makes the code 3 times smaller on ARM, and 5 times smaller on x86-64. That's pretty huge.

So all in all, I'd say that if those figures actually hold, then this approach is pretty solid. It's just surprising, given how much complaining there is about how Go's idiom of "if err != nil { return nil, err }", or Rust's "let v = some_fun()?" kills performance because of branch mis-prediction and hot path code bloat, so maybe those figures don't actually hold?
This suggests an advantage to purposeful infection by oral/eye rather than accidental by intranasal. It'll be interesting to see what the case fatality rate is when segmented by infection route.
You claim that the author is gaming the system, then go own without backing up that assertation. Are you saying that because Quora said it was so, that it must be true?

Quora offered money for questions, OP provided...questions for money. If they were spam questions, then can him. They quantity is irrelevant unless it was part of the terms of service.
A young citizen not being arrested for consuming weed seems good to me. When you multiply that event over the entire population, you have a huge regressive cost forced on these people. Imagine if they didn't pay that cost and instead lived their otherwise upstanding lives :) that is how you benefit society bottom-up.
Covid-19 Isn’t as Deadly as We Think
For a million dollars - no doubt.
I can definitely put down the $25/mo, but if I want to add two people who can help me out that jumps to $75/mo or $900/yr. I'm not at the stage where I can afford to hire employees yet (I'm the only one, and the drivers are contractors), so this would be a big expense for the company.
I was recently reading a book about Thomas Edison and it mentioned how he sent people all around the world searching for plant fibers that they could use as the filament in light bulbs. IIRC, they settled on a type of bamboo because the structure of the fibers were particularly conducive to their purposes.
I think there's a legitimate question here. Intuitively, if a non-N95 mask only stops 25% or 50% of incoming viruses, that still seems helpful? It's worth noting that in countries where wearing masks is normalized, making sure the general public can get some is a top priority.
https://www.worldometers.info/coronavirus/coronavirus-age-se...

These are worldwide statistics. Breakdown is by age, but I don't recall if there's other categories.
Compared to 2% chance of death from the virus? I'll take a 2% chance of blindness over 2% chance of death for example. Of course we don't know what the odds are for the negative side effects.
For folks just trying it out, 1 cluster is still free.
You could give them to health care workers and be even wealthier.
Sure. What questions do you have? I replied to another comment down below explaining why the pricing model is out of my reach, but I'll copy it here too:

>

I can definitely put down the $25/mo, but if I want to add two people who can help me out that jumps to $75/mo or $900/yr. I'm not at the stage where I can afford to hire employees yet (I'm the only one, and the drivers are contractors), so this would be a big expense for the company.
Perhaps, but it's a complete sidetrack. In the context of this discussion, "simple" was indeed being used as a shorthand for "accessible":

> Finally, this is going to be more accessible to more users to Mozilla since now they are using Matrix.

> I disagree, IRC is as simple as it gets. This might discourage some people from joining.
Just because it serves HTTPS on port :443 doesn't mean you should be using it. 'HTTPS Everywhere' style plugins are a broken concept.
Yeah, been experiencing the shady VC behavior more and more these days. Being upfront about not needing capital doesn't help as they continue to want to chat and contact you on every channel. Once you agree, it quickly turns into uncomfortable probing questions about financials and validation methods.

The reason becomes quite clear if you look at their portfolio. If there are companies like yours there, it makes a lot of sense as to why they want to know what's working with yours. They haven't invested in you, but they have in these other companies.

Almost every founder I've talked to has a story like this and warns against taking investor meetings/chats unless you're actively looking for funding and have done your research. Better yet, only follow through on warm introductions from other founders/people you know.
Why people think cloud providers are benevolent provider of infra is beyond me. Their margin is because people are willing to pay it. Either run your own metal (k8s arguably makes this easier than VMs along in the past) or form a cloud coop, but absolutely don't be shocked when a business is taking money off the table because they can.

Don't marry yourself to a provider, stay portable, it's just good risk management. Pricing changes? Spin up a cluster elsewhere, migrate data, migrate traffic, profit. The terms of the agreement can change at any time.
>corticosteroids may have no treatment effect

isn't the point of the corticosteriods to rapidly reduce widespread pulmonary inflammation that would otherwise kill the patient?
The full text mentions masks being particularly effective and inhaled antiviral meds that could slow the spread of the virus in airways. It also talks about the need for antiviral agents capable of crossing the brain-blood barrier. See the last 3 paragraphs of the full text.
For me the most useful advice has come in the form of “How should I spend my money?” Reddit has an excellent detailed flowchart [1] that echoes a simplified version that fits on an index card [2].

[1]: https://www.reddit.com/r/personalfinance/comments/4gdlu9/how...

[2]: https://www.npr.org/sections/alltechconsidered/2016/01/08/46...
Obviously yes, but that is question-begging. How does the novice programmer know that it is a good practice to use parentheses? x + y == z is correct, so it seems reasonable to conclude that x & y == z is also correct, particularly when the compiler does not complain about it.
To what extent? Please expand because this depends on how people's lives depends on the economy.

You can take good measures that slows down the economy without endangering people's lives. Of course you can also consider social unrest to be a risk but that's another matter.
I think this trend is not good overall, and people will eventually be very unhappy with it. I'd rather help you figure out how to use fewer clusters.
That's interesting.

Where is rhythm processed?
How can you possibly know that?
Investors Serve Up $53M in Series C Funding to Web Dev Platform Netlify
Can short bouts of running lengthen lives?
Seems very interesting but closed the tab after seeing google login
I see a lot of "may", "possible", "if", ...

Is this how people typically write a paper to Medical Virology?
I believe OPs point is about considering the longer term effects. If we prevent a million Covid-19 deaths with a rushed vaccine, but the vaccine kills even a few people and brings anti-vaxx into full swing and we get a nationwide diphtheria outbreak instead, are we really coming out ahead?
Google, walking back their commitment to software? gasp
So how likely is it that when summer comes the same will happen with the current coronavirus epidemic?
Decision fatigue
Large clinical trials require large numbers of patients, which thankfully we don't have, and also what we're trying to avoid.
Aluminum uses a lot of energy to refine, but not to recycle AFAIK. Notice that aluminum is easily the most profitable thing for people to recycle; people can collect cans and take them to a recycler and get paid a fair amount of money. The same just isn't true of almost anything else (except probably copper, and of course precious metals). Even steel, which is far more dense, doesn't fetch nearly as much in scrap value.

The thing about standard glass bottles sounds pretty good, but I can't imagine that ever being legislated here in the US. It would have to be Federal, and there's no way you'll get Congresspeople from across the country to agree to something like that. It can't be state-based because then it wouldn't work: you wouldn't be able to get the standard bottle adopted even within a single city, because part of the city is in one state and part is in another state or two.
Why would I get those side effects?

Remdesivir has already gone through safety trials years ago, it's in phase 3 now.
You could use it to extend range to a large campus, stadium, race track, farm or even between two office builds in close proximity. It’s somewhat niche but there is a use case for short line of sight connection.
Kids lull us into a false sense of security.

Stories of parents turning the back for a split second, only to see their kid missing is the norm.

A scary moment like that reaffirms what you said--it's too easy for something terrible to happen. I've experienced it too, just not in a pool.

I'm glad your child is safe.
Gravity 7.0
For an API, or really any software, you have a large fixed development cost plus a small marginal cost per request. So the problem is that you have to price your usage high enough to cover the fixed cost. Depending on the usage that can be hundreds to thousands of times the marginal cost.

Think of an address validation service. The cost to develop the service might amortize out to $0.50 a request while the infrastructure to run the service will cost a fraction of a penny per request. To make a profit the company would charge $0.75 an address. As a customer I might be willing to pay a dollar per address to validate a billing address. For addresses collected as part of a marketing campaign maybe it's only one cent. So there's a potential benefit from the service that isn't being realized due to the pricing.

I deal with this all the time at my job. The vendor of the software I implement has been offering a fixed price per ticket/process* created. This pushes us to implement a single big process when combining a bunch of smaller processes into one bigger one is the better way to do it. It also limits the problems we can solve to those worth more than X dollars per process where X is the cost the vendor charges per process executed.

*Stuff like credit card disputes or managing the employee onboarding process
I’m not a PowerShell fan by large, but you can tell a whole lot of effort went into this.

And for what ends? Seemingly to make more Microsoft technologies and APIs available on non-Windows platforms.

I genuinely like this part of the “new” Microsoft.
Because the industry executives are as dumb as the politicians and had no other ideas to move the needle on what is essentially a static commodity like the electricity grid in a plateauing market.

Doesn't mean it was ever a practical idea.

I've always said we can make laws when or if it actually happens. Because in the meantime we've all been getting upset and wasting time over highly impractical scenarios... and net neutrality has had a serious force and backing, which is good. But in regards to the FCC there's so many more important things to be spending our hacker concern-resources on IMO. For example the FCC (or FTC) should be looking into the millions of Indian (et al) call scammers which are wrecking havoc across the western world - which is an obvious and very real epidemic of fraud that is happening right now and very few western gov are doing anything about the millions of older people getting scammed every day. Much of which transits through legit American infrastructure and web services.

Then wake me up when a single ISP or mobile operator does anything close to what people have been claiming they will do.
This may sound very stupid, but...

As a sort of "vaccine", would it make sense to have people intentionally infected orally so they build up antibodies before it has a chance to spread to their brain?
Unmasking the Inner Turmoil of Founders
Somewhere around 1%. The 10x multiplier on fatality rate seems to be fairly consistent across age groups. Note that the CFR for this virus is still largely unknown, and is vastly different in different regions.

https://www.cdc.gov/flu/about/burden/2018-2019.html
I hear more people talking about anti-vaxxers than I do from any actual anti-vaxxers. I don't think they are all that powerful.
Webinar: Using AI to auto-detect incidents caused by chaos experiments
Why Pandemics Activate Xenophobia
My current stance on that is that the account in Genesis is older than the Babylonian version, despite not having yet discovered any written record of the former older than the latter. And again, that the Genesis story was passed orally for some time, and many cultures appropriated and molded it to reinforce the divine power of their government. As discussed in the previous post, I'm biased because of personal experience. Though for precedence, consider how the 1947 discovery of the Dead Sea Scrolls brought a written record that was a millennium older than any other known at the time (I don't know much about archaeology, but I think that's accurate).

And another example of archaeological discovery affirming Biblical accounts after a period of doubt (from https://en.wikipedia.org/wiki/Hittites#Biblical_background):

> Before the archeological discoveries that revealed the Hittite civilization, the only source of information about the Hittites had been the Old Testament. Francis William Newman expressed the critical view, common in the early 19th century, that, "no Hittite king could have compared in power to the King of Judah...".[10]

From the link you shared, this theory would be interesting to explore:

> Based on an analysis of proper names in the texts A.T. Clay proposed that the Enuma Elish was a combination of a Semitic myth from Amurru and a Sumerian myth from Eridu—this theory is thought to lack solidity, and specifically any historical or archaeological evidence.
That's why there are military surplus stores all over the country. Great stuff to be had -- cheap!
If I understand this correctly, could wearing nose clips and only mouth breathing be an effective strategy to reduce impact?
Imagine 1 million users decide to give it a free trial month and only 5% decide to book minimal donate. You barely will pay the month bill and will have to close "the business" before it get started. So start looking for an Angel or apply for Y-funding as high risk venture with no financial model
Reddit seems like an odd choice, but there is the personal finance stack exchange site https://money.stackexchange.com/
Mortgage Brokers Are Hiring Like Mad to Handle Demand as Rates Plunge
Even if your worker nodes are pre-emptible, the master nodes are not. The management fee covers running those master nodes and many other core GCP integrations (like Stackdriver logging and other advanced functionality). Billing is computed on a per-second basis for each cluster. The total amount will be rounded to the nearest penny at the end of the month.
I'm not sure any provider appearing to capitalize on a momentary pricing decision is a great idea. All are too big and things change too fast for any crowing as if anything is a long term decision.

Replies on another thread by alleged Google employees appear to indicate they are learning on the fly that doing support matters and costs money.

There are a lot of comments from people wanting free things. You may get those things for a while but it won't last. Free only works for so long in anything no matter how hard that is for some people to figure out across all aspects of life.
Something to consider: even if it was "just like a flu" (which it isn't, enough commenters already pointed out the differences, but let's just for the sake of my argument assume that it was), it is a matter of fact that this would then be a "second flu" going around at a time at which doctors and hospitals are already well-loaded with caring for patients that have more serious trouble with the "real flu" that happens to be at the peak of its activity just at the same time.

The "real flu" is relatively non-deadly for most people (even though it still kills a lot of people in absolute numbers) precisely because the healthcare system is capable of providing care to those requiring it because of the flu. It can do this because the flu is a relatively well-understood phenomenon, it comes every year, and although the exact mutations of the virus differ between the years, the overall characteristics of the outbreak are relatively well-known in advance. There are also vaccines against the flu (these are a big thing in allowing the personnel in the healthcare sector to do their work, which of course exposes them to flu patients) and there is medication available that's able to quicken the recovery. Nevertheless, the flu still puts a lot of strain on the system, and having a "second flu" of entirely unknown characteristics going around, possibly even infecting the same patients, for which there is no vaccination and no medication at all is not exactly a thing to take light-hearted.

I would not be surprised at all if the "real flu" would later be found to be much more deadly this year than in the years before, not because the virus was any different than before, but because the additional strain due to COVID-19 negatively impacted care for flu patients.
Where have you seen this?
Same, Notion feels like a more powerful generalist tool for this case with the power of tables and collaboration.
Because last time I used it (Anki), the app didn't allow you to "pause" your learning. It happened to me a couple times that I missed a week for some reason (usually a deadline), and when I came back to my deck I had hundreds of well-known cards to catch up to.

This created a vicious cycle: my commute was no longer enough to review so many card, I kept falling behind, and the pile just kept getting bigger. I started dreading opening the app more and more, until I officially gave up and deleted everything.
This is awful - I don’t think GCP is fully aware of their position in the market as the second, inferior choice. I took a bet on the underdog by using GCP and they bit me back in return. Especially considering their ‘default’ kubernetes config automatically sets you up with three(!) control planes in replication, that’s, as far as I understand, $~300 added to our monthly bill, for nothing.

Oh, and per their docs, three-control-planes decision is not reversible - I cannot in fact shut two of those down without shutting down my production cluster and starting a new one. https://cloud.google.com/kubernetes-engine/docs/concepts/typ...

Awful. Just so awful.

Edit: To answer some questions below - we have a single-tenant model where we run an instance of our async discussion tool (https://aether.app) per customer for better isolation, that’s why we had bought into Kubernetes / GCP. Since we have our own hypervisor inside the clusters, it makes me wonder whether we can just deploy multiple hypervisors into the same cluster, or remove the Kubernetes dependency and run this on a Docker runtime in a more classical environment.