skysight-inc/HackerNews huggingface dataset:
Good jobs in pharma pay pretty well and are nearly competitive with SV (I've worked for Genentech, Google, and a small biotech startup). Pharma has no lack of smart people, but modern pharma is really just a rent-seeking entity (goal is to maximize profit on fairly small stable of well-defined drugs) while maintaining a portfolio of investments in smaller pharma and biotech companies who do most of the innovation, while pharma handles ads, sales, distribution, manufacturing, etc.

Creating cures for diseases is a systemically complex problem and it's not clear that "more smart people" really is the answer, versus "do a better job". In many ways, the smartest folks in the room are the least capable at moving drug discovery forward- smart people want to work on cool new problems, explore nifty theories, but don't want to deal with the day-to-day challenges of reliably identifying new drugs.

I left drug discovery because the systemic challenges were too great; it's not like you can be smart or work hard and solve a problem. You have to play a very long game, do a bunch of tedious and boring things, and master politics to get a drug to market.

One thing to note is that some drugs really do cost a lot to R&D and to manufacture, and I think those drugs should reflect those costs; but many companies overprice their drugs to maintain absurdly high profit margins. That doesnt' translate into larger investments in future drugs.

Gilead has been very good at this, but after working for a biotech startup that had a deal with Gilead to work on NASH, I've become extremely skeptical. This is a "disease" where nobody can agree that it's actually a disease, and worse, it could be far more easily treated using simple obesity reduction techniques, instead of spending billions to create a drug that helps people who are extremely sick.
"Don't tell me what the fuck to do - tell me what you did and what has worked for you in a given context."
Never attribute to malice that which is adequately explained by stupidity

- Hanlon’s razor
The article raises several good points, but inexplicably includes Taiwan in a map of coronavirus in China. Might as well include North/South Korea as well.
Show HN: Breezy – A Marketplace for Easily Finding the Best Pet Insurance
a 12 month postpone is in order
Its funny that for a software company ESRI basically owns the GIS market. I really liked how this article goes over processing a projection and communicating reality w/o panic and sky is falling insanity.
Nvidia GTC '20 Could Be Massive
Last I checked that still is international as it involves 2+ nations.. Not sure why you had drag Orange Man bad into this. You come off as a bit deranged.
It really depends on a lot of factors. Not every scientist who has their name on a patent that led to a billion dollar drug saw much money from it.

the university sees much of the upside.
> These are inherently conflicting things. Section 230 gives special protection on the assumption that platforms aren't involved in selecting what users post. But then with the other hand, platforms are selecting what users post via their content guidelines.

They're not contradictory, they're unrelated.
Elixir Wizards S3E14 Bonus Toddcast and Lonestar Preview
San Francisco. Non-plastic straws only (so paper or even bamboo is fine), although there are a few businesses trying to work through their existing plastic stock on the down low.
Curious if you were active on the precursor to postgraphile why you feel Prisma is a better option. It's been my experience as well, but would love to hear what the deciding factors were for you.
Makes sense. That highlights the difference between individualistic and collectivist cultures. But if the measurable, scientific benefit of wearing a poorly-fitted mask is minimal at best, masks are pandemic security theater anyways. And I'm unsure if collectivist cultures consider that. Why bother doing something for the group, if the thing has no actual benefit other than appeasement.
for once remote video and collab will have first class value
“The results speak for themselves: Pinterest..., Twitter..., FlipKart..., AliExpress..., Forbes..., Lancôme...”

Did any of them use Pep? Doesn’t look like it.

I’d say this is deceptive marketing. Not sure if it’s trademark violation.
Protocols allow for namespace restrictions on CA certificates. There could, in concept, be something stopping you from spoofing google.

https://www.ietf.org/rfc/rfc2459.txt - section 4.2.1.11, Name Constraints

Given that I don't think you can actually buy that kind of cert, and the term "CA" is accepted to imply "universal CA", you're correct.
Chime, a Go Editor for macOS – v1.0 Now Available
Your site is not Lighthouse compliant. Why should I trust your service?
It depends on the airline. I've gotten no-hassle refunds from Delta and Cathay Pacific in the past ten days.
I posted on ProPublica article earlier https://news.ycombinator.com/item?id=22430735
Hi everyone, we’re super excited to share with you that we just launched our startup Breezy which aims to help you quickly find the best and most affordable insurance for your pets!

Product Hunt: https://www.producthunt.com/posts/breezy-2

This is our MVP launch and we’re still at least a few weeks away from the solution that we initially envisioned. However, after the first week of YC Startup School course where Michael Seibel emphasized the importance of having an MVP and getting feedback from customers early on, my Co-Founder Richard & I sat down and discussed what we can do or how many features we can trim down to get something out in 4 weeks instead of 10, which led to our launch today!

The reason why we decided to build Breezy is that as a pet parent myself, I found the pet insurance search process to be extremely redundant and overwhelming as you have to fill out the same application form over and over again just to get a quote. In addition, understanding each provider's policy and exclusions can be very frustrating as they can be quite different depending on the plan you choose. Also, there is no clear evidence as to why the prices vary so much when comparing one company to another.

Our goal is to make the pet insurance search process easy and transparent. And we’re in the process of adding more providers to our website. Please check out our website here and feel free to reach out with any questions or comments. All feedbacks are greatly appreciated!
https://www.businessinsider.com/apple-product-placements-in-...

Barter is still a form of payment and all of this screen placement occurs under contract and marketing direction from Apple. I still view that as paid product placement, which is different than if the production included Apple products without any contract or guidance from Apple.
Please let's not go off topic into that one. A plausible interpretation is that someone made a mistake. Even if it wasn't a mistake, there's no new information here that could support a discussion, so we'd end up with a generic Taiwan/China flamewar. Such threads are bad because they're repetitive and predictable, and of course get nasty.

https://news.ycombinator.com/newsguidelines.html

https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu...
Most public bathrooms also have automatic doors (if you wait long enough)
The UK has long been an early adopter of proper web design for government websites.

Seeing the average Canadian gov website, and hearing stories from people who've worked on some at the federal level, makes my head hurt.
I think you described the raid-0 device I was describing. Whoever came up with the idea for that device, I can say with confidence, does not understand the failure rate of SD cards and the mathematics of why raid-0 is a bad idea.

You are right though in this "overarching" point that it is very niche and you can probably have a decent solution with USB. I would think that might get a little more clumsy and consume more power than a single board exposing all slots though.
RC Car Storage and Display Case – Part 4
FB/Oculus has been pushing remote events via VR heavily since day one.

Seems like a good opportunity to send each attendee an Oculus Go and do the whole event in VR.

Sure would save a lot of carbon, also.
If it’s a static bundle, I think cloud deployment should be trivial...at worst they can add a feature to download a zip and sync to s3. I wouldn’t rule out this tool based on this fact alone.
Money: These videos are playing less than they would have without being restricted, therefore less associated advertising is playing. It's probably not much money on Alphabet's scale.

Users: Somewhere in this nation, there is a high school administrator who consents to students learning about politics. There might even be more than one.
They catch the water droplets.
They are there due to contract with Apple. https://www.businessinsider.com/apple-product-placements-in-...
Wouldn't the quick discovery and level of care also factor in?
then don't read it
Apple absolutely does this.
It's possible to add head elements with JavaScript, so you could define any number of things with a single added script. Not sure if that's what they're doing here, but certainly a possibility.
Printer toner linked to genetic changes, health risks in new study
There are no billionaire janitors, drycleaners, or chefs. I don't think there are even any billionaire software developers, doctors, or lawyers. There ARE billionaire business owners of all those things, but for the vocations themselves, it doesn't matter how good at that particular thing you are, you can't earn unlimited wealth strictly off those vocation specific skills and hard work unless you pivot and move your time and effort into something else.
> it turned out I am blacklisted from requesting new certs for 7 days, per their rate limits

The rate limit for failed issuance is one hour, not 7 days. The 7 day rate limit applies when you successfully issue 5 identical certificates; then you have to wait 7 days more to issue a new identical certificate.

https://letsencrypt.org/docs/rate-limits/

It's unlikely that you would be subject to the 7 day duplicate certificate limit due to a Certbot dependency problem, because the dependency problem would have to allow Certbot to obtain the certificates correctly but fail to save them properly.

(Source: I'm a Certbot developer.)

I should also add that I'm really sorry that you experienced an installation problem on CentOS. Dependency and packaging problems continue to be a challenge for Certbot and our colleagues are still trying to find a more universal solution to them (probably involving snaps).
I'd like to see a comparison of the energy costs of canning versus maintaining the refrigeration chain needed for fresh, my gut tells me that canning is a centralized process and therefore more open to efficiencies than refrigerated trucks and storage.

But anyone who's worked produce can tell you a lot of stuff gets thrown away at each step before it reaches the consumer.
There are so many use cases today where you are working across countries and languages and while most people generally speak english, it is not a given. This would truly be an amazing tool!
Isn't smoking much more common among the Chinese than this sample suggests? I would expect a random sample to include more smokers than not. It may imply that the act of smoking or the associated health states reduce the likelihood of infection, even if they increase the likelihood of a bad infection if it does land.
There’s a 1.4 change that stops you from trying to eat fruit when feeding jars, as long as you keep the button held down as you move. I wonder if it’ll be fixed for crops vs. machines someday.
My general rule is if you can't add two values together then they shouldn't be represented as number types.
The implication here is that reforming prices would destroy innovation in pharmaceuticals, but marketing costs dwarf R&D expenditures. These companies also benefit from huge, decades long investments by government in basic research.

Edit: It’s also worth pointing out that it’s not the scientists and researchers who are raking it in — it’s executive managers. It’s not about punishing value creators, it’s about stemming value extraction, aka rent-seeking, aka what makes markets not free according to Adam Smith.
I remember many years back uploading a module to CPAN at version 0.001001 with docs that said "actual docs not written yet, this release was made so other cpan authors I was talking to could experiment more easily".

Two days later I got a one-star review on the now-defunct cpanratings site complaining about the lack of documentation.
> I was saying the same thing you are: the items of the bundle CANNOT be mapped individually

I wasn't saying this, because it isn't true. Bundled items are usually processed as a set of simultaneous individual purchases, with a discount applied to each of them.

What do you think of bundle #1 and bundle #2? How would you expect refunds to be processed in either case?
Thanks so much for the comment! In order to offer this testing and give back a result report that can really be used by a doctor, it should be physician-ordered, processed in a CLIA-certified and ideally, a CAP-accredited lab, have the lab report signed out by a clinical lab director, and ideally (for ethical reasons) offer genetic counseling to patients. From the bioinformatics perspective, the bioinformatician should be trying to take in all of the medical information we know about the patient and apply this to the analysis. This is what we offer. In contrast, with Dante labs, you basically send them your sample and get back raw data and some very basic reports. If you bring these to a doctor, the recommendation might be to just get another genetic test via a lab that follows all of the procedures as stated above so a person may end up doing it twice if they go that route. Ours offers the complete end-to-end solution that you would get in the healthcare system while Dante labs is really just a way to access your raw DNA.
By hefty price, did not mean any potentially mishandled quarantine measures. Quarantine is a compromise, a hard one, and I am certainly in no position to form an informed position on this matter.

I meant the human rights violations perpetrated by the regime. This is always the price we seem to have to pay for a "competent crisis handling". I would indeed rather choose a free, but impotent country.

It is ironic that personal freedoms and public health are not often compatible. Doubly important to be aware of what we are being sold.
This might be related: https://github.com/docker/distribution/pull/2906
BERRYVILLE, Va., Feb. 13, 2020 – The Berryville Institute of Machine Learning (BIML), a research think tank dedicated to safe, secure and ethical development of AI technologies, today released the first-ever risk framework to guide development of secure ML. The “Architectural Risk Analysis of Machine Learning Systems: Toward More Secure Machine Learning” is designed for use by developers, engineers, designers and others who are creating applications and services that use ML technologies.

Early work on ML security focuses on specific failures, including systems that learn to be sexist, racist and xenophobic like Microsoft’s Tay, or systems that can be manipulated into seeing a STOP sign as a speed limit sign using a few pieces of tape. The BIML ML Security Risk Framework details the top 10 security risks in ML systems today. A total of 78 risks have been identified by BIML using a generic ML system as an organizing concept. The BIML ML Security Risk Framework can be practically applied in the early design and development phases of any ML project.

“The tech industry is racing ahead with AI and ML with little to no consideration for the security risks that automated machine learning poses,” says Dr. Gary McGraw, co-founder of BIML. “We saw with the development of the internet the consequences of security as an afterthought. But with AI we have the chance now to do it right.”

For more information about An Architectural Risk Analysis of Machine Learning Systems: Toward More Secure Machine Learning, visit https://berryvilleiml.com/results/.

A link to the PR on the wire: https://onlineprnews.com//news/1143530-1581535720-biml-relea...
Since that's pay-walled, I found this which I'm currently reading and seems to cover the same paper: http://news.mit.edu/2020/force-strong-neutron-stars-0226

Edit: Definitely covers the same paper.
This is absolutely the case. There are other areas where 'standards' aren't used because of accessibility reasons; a prime example being the HTML5 built-in validations. They just aren't reliably accessible enough across browsers/platforms.

The GOV.UK Design System is extremely well thought out, there's reason and sound arguments behind every decision - and the best part is that it's all developed in the open.
Apollo is more than just GraphQL -- it has built-in caching, and gives you booleans for loading state, and more. If you were to roll your own wrapper around window.fetch, for a simpler facade to work with (when making network requests in React), you'd end up with something like Apollo's interface. And that really useful API surface has nothing to do with GraphQL as a specification.

I used to roll all of this stuff from Redux, with actions, reducers, the whole 9 yards. Apollo let me gut all of that-- since I was only using Redux to store data retrieved over the network. Now I'm not hear to preach Apollo specifically, but it's the only client I've worked with, and I can achieve higher productivity with it than working a lower level.
The problem we have is that whilst lots of people think that there should be new regulation, no one can agree on what it is and in the mean time you have to contend with:

* Both partisans pushing for legislation they can use to beat the other side with

* Monopolistic entities such as facebook that intend to use 'regulation' as a moat - writing legislation that only restricts them from doing things they already don't do

* Incompetent legislators who don't understand the issues - since they were born before colour tv was invented, let alone smart phones and the internet.

And that's before even considering the obvious anti-competitive mergers that have been happening. You talk about breaking up Facebook/Instagram/Whatsapp. Why were they allowed to be sold in the first place.
According to the Chinese papers, something like 15% of cases are serious and need hospitalization. If it does become widespread, it would be a major calamity (though most people would survive and the world would move on once it is over).

As to whether it will become widespread, the jury is still out. China appears to have gotten it under control, but it took drastic measures to do so. The rest of the world has yet to demonstrate an ability and willingness to do the same. There is a decent chance this will spread as widely as the swine flu did, but with more than 20x the case fatality rate, we would be looking at tens of millions of deaths worldwide.
Just tried hasura, it is amazing to get all crud graphql apis out of box.

How do we add business logic ?

Folks @hasura, where do we learn about haskell ? any helpful pointers much appreciated.
I feel like 'by Jon Bentley' should be restored to the end of the title to help differentiate it from the earlier posting to which this is a reply.
That drives me nuts... Need to always carry some paper towels on hand for times like that.
>They're going to launch a browser update that removes support for most extensions

It's not like they're "removing" it, they rewrote half the browser and not all of the APIs are hooked back up yet. They're going to be added back eventually.
We render lard from bacon and chicken fat and refrigerate them in jars for later use. Both work nicely with Chinese dishes, and this reduces the need to buy cooking oil.
Without a worked example to look at, this looks like an email harvesting operation.
True, frybread (which uses lard) is really good but really not healthy for you.
Ubiquitous mobile phone location tracking will be useful here

“Text COVID19 to get notified if you were in a place where Coronavirus was present”
You have to take into account that 80% of cases are not severe, so you could have it and just think it was the flu. Most people wouldn’t go to the hospital in that case, so that 7.8% figure is not realistic. The WHO numbers (2%) do at least try to take this into account

I’m legitimately confused why we’re seeing these responses make top response on hn. It’s WEIRD
No one’s talking about pegging the salaries of the researchers who are in a completely different class than executive management. It’s a Straw Man argument.
Congrats on the launch! I'm a VC that's invested in this space and I think you are hitting on an important distinction between physician-ordered and consumer-directed testing (we often call the latter "medical tourism").

Another very important part of the testing process, particularly in the rare disease space, is the pre- and post-test genetic counseling. I see that all users have access to genetic counseling, which is great - just curious about how you are handling that part of the process?
> macOS Mail... made with web technology

Do you have a source for this? Mail content may very well be rendered in a web view (which is unsurprising given rich text and HTML are underpinnings of email), but I’d be surprised if the UI and widgets aren’t native.
And I think I saw somewhere that United gave refunds to people who were planning to attend Mobile World Congress. It's mostly up to the individual airline but many of them seem to be being understanding. (Which isn't to say you'll necessarily get a refund if it's just a generic I don't feel comfortable flying any longer rather than a canceled event.)
Thinking Rationally: 3 Examples
That's not how the word is usually used within development in my experience though.

I think most devs think of sanitization as "make X safe", not "see if X is safe, if not reject" since that is usually called validation.

Using hand sanitizer does not remove your hands if they have harmful bacteria. The hands are still there, just cleaned from (some) of the harmful parts.
Did Woodrow Wilson cause the spread of Spanish Influenza worldwide?
Panera launches unlimited-coffee subscription for $9 monthly
(disclaimer: I work for Typeform)

Typeform is the perfect tool for this, people have used it to create "user profile" and present recommendations depending on what they answered. (check BeardBand example: https://www.typeform.com/blog/inspiration/beardbrand-persona...)

You can also accept Payments directly on the typeform using Stripe, no need to code that part. There are plenty of salons, freelancers and businesses that use this feature to power their business. (https://help.typeform.com/hc/en-us/articles/360029570591-Pay...)

You can connect your Typeform to many other tools to automate other tasks like adding customers to a mailing list, a loyalty program, or create a calendar event. (you can get an overview over here: https://typeform.com/connect, we also integrate with connectors like Zapier, Integromat, Parabola...)

Hope it helps!
Good luck kickstarting this business!
I'm pretty sure car companies did similar things in the past in movies showing good guys chasing bad ones.
Subscription Models: Changing the Economy
Iran is an outlier because it has an extremely poor healthcare system for a country of its size or GDP.
Incidentally, I made a demo app with proportionally sized circles like they suggest, and it allows to move day-by-day to see the progression. https://coronaprogress.com/

I am gonna update the numbers for today.
So, Apple care enough about their brand that they are circumspect when it comes to what they pay for in regards to product placement? Say it isn't so!

Literally everybody does this. Even the US armed forces do this [1] eg:

> A study of the internal correspondence shows that the script changes the DoD requests fall into three categories:
accuracy (historical and technical), behavior of individual serviceman, and overall image of the military.

[1]: https://preserve.lehigh.edu/cgi/viewcontent.cgi?article=2328...