skysight-inc/HackerNews huggingface dataset:
How thoroughly have you compared yourselves to existing options like Invitae? They appear to offer pretty much what you are describing for a similar (slightly higher) price [1].

I feel like you may be underestimating both the maturity of the existing market and the complexity of doing what you are proposing at scale. Are you issuing clinical reports for your results? If so, who is doing that as neither of you sounds like you would meet the normal requirements for that.

[1] https://www.invitae.com/en/physician/category/CAT000168/#exo...
> In contrast, Python encourages the creation of monoliths of the type McIlroy criticized.

unfair and gratuitous criticism of python... i have seen and written many small tools you can run using "python -m".
I would hazzard a guess that quite a lot of engineers are into cooking because it can be a highly technical and scientific process that involves chemistry, physics, and engineering with delicious results.

And the highly technical paper in this post attests to that.
EDIT: removed my inaccurate comment, misread article
How would you know the number of infected people? You know the number of infected people with symptoms that were severe enough to get tested.

For the same reason: How would you know the number of people who have recovered? You know the number of people who were observed and then recovered.
Lessons from the Screenplay: Casino Royale – How Action Reveals Character
I initially thought the same thing, but revised my thinking after I kept reading. I made a comment here [0], but the author is correct that in this case (as in almost every conceivable visualization case), mapping the cases-per-person value is necessary. The mapping of absolute counts almost completely hides the severity of the impact in Hubei province, and how the severity in other provinces has a direct relationship to their geographic distance from Hubei.

> These political divisions are arbitrary anyway.

Not sure how interstate activity and travel is regulated/limited in China (in normal times), but in the U.S., state borders are not just some imaginary political construct. Laws and services – and therefore, impact to respective populations – can drastically differ by state lines, and ignoring that is a huge mistake.

[0] https://news.ycombinator.com/item?id=22436842
Nah fam. It's cool to write your text chat app or graphing calculator in Electron. Moore's Law will totally catch up and people won't miss the hundreds of MiB of RAM it takes up.
Similar idea to base 58, introduced with Bitcoin.

https://en.wikipedia.org/wiki/Base58
I think part of the actual, non-hyped benefit is that it adds type definitions to incoming and outgoing fields on the client side. Working directly with JSON is kind of fucking awful. Attempts to fix it are often of an even more unpleasant "now you have two problems" sort (JSON-Schema, for example). Any well-supported standard for typing interfaces for data sent to the browser & other REST-consuming clients, even if the underlying transport remains JSON or whatever, is welcome.
Well I guess that remains to be seen :)

There are lots of excellent cross-platform editors out there. We're macOS users, and we just wanted to build something that catered specifically to that crowd. iPad is close in some respects, but would really need a totally different interaction model.
Use self-hosted repos like gitlab or fossil, and then mirror the public parts to github.
I find the site decently fast, definitely ugly but then again I don't want it to get a reddit-style redesign either. The information density is ok right now, and I'm actually impressed by the wide range of functionalities they have, related to reviewing books and updating your progress.
Maybe I misunderstand you then, to me you made it sound that was a given. Those companies have undoubtly different history and, to me, rent is a relatively recent issue and over hundreds of years it might not be a factor. I pretty sure national mints have been moving around for instance. They are not location dependant.

That said, I might be wrong, it would made an interesting study to try to acertain what are the common factor to those companies. If any.
Ask HN: Why should my company use source control?
Hi guys,

I'm a programmer at a big company. Prior to working here, I have worked at several other organizations who all used Git as a version control system. As a result, I am very well versed in how to use git.

However, my department does not use version control at all. They simply do not see a need for it. So far, most of my reasons for using source control have been discarded due to another tool already doing that thing. For example:

* Git is a backup of your source code. If your code is on the server, and you lose your laptop, you're still relatively OK.

* Rebuttal: We store code on a network share, which is backed up automatically every night.

* Git allows people to easily collaborate on the same project (branches, pull requests, merges).

* Rebuttal: We rarely have multiple people working on the same system at the same time - the benefits will be negligible, and only add complexity to our daily work (this is true, work here is very silo'd).

* Git allows you to store a version history so you can see what changed and why.

* Rebuttal: We don't care for the past: we only care about the current state and what it's not doing correctly (or needs to do / enhancement).

So, HN, my question to you is: what other benefits of Git / source control exist that I can bring to management to hopefully swing our team into using it daily?
Looks like GDC is falling apart as well.

And I was going to book tickets to the Qt conference, I’ve changed my mind on that one.
The service industry such as fast food has virtually no "paid sick days", and conveniently are jobs with lots of people interaction, poor pay, and poor if any health insurance.

So you "might" have the cold or coronavirus - do you go to the ER (costs hundreds even with insurance) and lose out on your pay? (Not to mention you'll likely have your hours cut as "punishment"). Or do you tough it out and keep making money that you need to pay for your rent?
Eppenberg SBB Railway Tunnel – From installation to the breakthrough
You're forgetting that it's a season for the pollens and so many people have allergies against that, many people start wearing masks at this season.
But the Corona has pretty much wiped masks off the shelves and those who need are having a hard time getting one.
Goodreads was that anonymous site once upon a time. You're just not an early adopter and that's okay. That's no reason to not create a better alternative.
“Question on coronavirus. NNT preferring cars over public transportation”
iMX6, for example, can boot with no closed blobs at all. vote with your money
Exactly - they’re showing that Etsy is getting the upper hand here in an ad fee arbitrage play.
Thou Shalt Love Thy BBS: Distributed Experimentation in Community Moderation [pdf]
I keep wondering why bathroom doors aren't designed to swing outwards by default. Then you could open them without touching a handle.
Adım da herşeye yeniden başlamak – .Kadına ve Erkeğe faydalı yazılar
you could start altering the virus-

you could create an mRNA and arrange the proper signaling and delivery [hopefully] and do something very risky like try to biohack an adaptive immune response into a vaccination

thus the disclaimer ~ dont put it in people
Show HN: Ecosim – A cellular ecosystem simulator toy for Linux written in C
I mean, I generally agree, but I think it's already problematic to frame it as "user input that isn't already known to be good". Because "J. O'Brien" is known to be good. The problem is that anyone thinks in the first place that some semantically meaningful input value for some reason is not good.
Yeah, I think the actual answer is that the number of tests on that page is not even remotely up to date, and the CDC has more important issues on its plate than updating it. As I understand it the UK testing criteria are very similar to the CDC's and also require travel to an affected country or contact with a confirmed case: https://www.gov.uk/government/publications/wuhan-novel-coron... The government here is just starting to roll out more general testing of the population to selected cities, but so is the CDC over in the US, and in both cases it's intended more to detect widespread spreading than to catch every individual case.
> training to use

I keep hearing this but don't understand. What exactly needs training?
And that's still ignoring the factor that many of those care workers will get ill themselves compounding the problem significantly.
A great example of why a post-scarcity economy will never happen. Only a miraculous invention (Replicators) will ever push production beyond a human consumption demand curve.
Looks like a normal discussion thread. Not sure what you’re pointing to here. Do you have some evidence of bad behavior? otherwise your comment is the one that looks petty IMHO.
I really like the idea of the Unix model as well, but you're not going to be able to use it effectively to write an actual application. If you're writing a word processor and you need to find the levenshtein distance between the most frequent word pairs (maybe some measure of how alliterative/consonant/assonant your document is?) then you're probably not going to be building the word processor using the Unix model, and even if you are (the closest you can get is probably using Tcl/Tk?) then it's still best to write out what you're doing as clear as possible. Note that it took me about 5 minutes to figure out what the shell pipeline presented in the article actually does, and multiple times my reasoning about it lead me to think "wait, does this actually do what it's supposed to do?"
Great question! In addition to the result report, we share three different types of files with the patient:

(1) The FASTQ, which contains the read data from the sequencer (see https://support.illumina.com/bulletins/2016/04/fastq-files-e...)
(2) The BAM, which contains sequence alignment data (you can learn more here: https://software.broadinstitute.org/software/igv/BAM)
(3) The VCF, which contains the variants present in the patient as compared to the human reference genome

We map all >20,000 genes in the human genome, which covers 85% of all known disease-causing mutations. Genes make up about 2% of your DNA.

Regarding integrating this into ongoing healthcare for patients: continuous re-analysis of a patient’s genetic data is important, for two reasons: (1) we discover 100-150 new disease-causing genes every year, which means we can return results today that we couldn’t a year ago, and (2) a patient’s symptoms change over time, which matters because we analyze the patient’s DNA for what’s causing their symptoms. Plus, a lot of diseases have a late-onset, which means you might be perfectly fine until your thirties, and all of a sudden you start developing a condition that you didn’t know about. Adult-onset ALD is an example of such a condition (https://www.mayoclinic.org/diseases-conditions/adrenoleukody...).
The 'Cloud Gate' in Chicago has a bunch of bullshit around it re licensing and photography permission. Asinine for a piece of 'public' art.
When I am frustrated by broken software and the general state of our IT industry, watching this video and what they accomplish in tunnel boring restores my faith in humanity.
The amount of people involved, the precision, planning and execution are excellent
They also tend to lose function when they are gutted by politicians.
> In my experience, deciding not to do something is unlikely to be intentional.

That's some weird experience. A decision is by definition intentional. It's literally "a conclusion or judgment reached after consideration". The moment a person with power of decision is made aware of an issue both action and inaction become conscious, deliberate decisions.

> did you come to this conclusion based solely on your prior opinion of their actions?

That's quite the assumption given the above and the fact that I was pretty clear that it's based on their continued stream of "mistakes" that tend to be massively in the company's favor. Almost feels like you made it in bad faith.

How many mistakes would you say it takes to make one start beefing up their internal processes so millions of people don't accidentally suffer repeatedly? How many before you start to at least consider that it can't be constantly attributed to bad luck? Would you feel different if a company kept overcharging you by mistake and never returned the money or fixed the issue? But now it's "just" and endless stream of your private data. Uncommon sense...
Doe Is Recycling Nuclear Waste to Produce Fuel for Next-Gen Nuclear Reactors
Why are there so many acronyms like AFAIK or OTOH? What do people do with all the free time they save from abbreviating as such? :P
This seems dangerous.

Growing up as an Asian American, my family's gas stove definitely wasn't hot enough, but we also had a separate butane burner that was rated for indoor use. (You could also use it for things like hot pot, so it's not like it was the only thing we used it for.) So long as you have a well ventilated area not very close to a smoke alarm you should be good.
Germs probably survive better on your skin than on the cold metal tap in the bathroom. Food safe handwashing says use a paper towel to turn off the tap after you are done drying your hands with it.
An example project using Pep. Most people are going to be skeptical that this can be done with a single line of code.
People like to pick on straw bans but the reason they're a thing is because plastic straws represent a substantial portion of the trash found on beaches and in waterways. And like plastic trash bags, plastic straws don't degrade, they just get ground up into smaller and smaller pieces.

They can also choke fish and birds if they get caught in the throats, or poke holes in the stomachs/guts of fish and birds.

Plastic straw bans may not make much sense in the Midwest, but they do matter in coastal areas.
> Create PRs to Babel, Webpack and ESLint

Why should anyone contribute to projects that have a completely different philosophy from what they would write? I doubt that the authors of those three projects would welcome any PR removing all dependencies of their tools with or merging all 3 tools into one.

Also, what's the problem with creating new things and fostering competition and advancing the state of our profession? Why is experimenting so frowned upon by some people here in Hacker News?

By the way, the author of Rome is also the author of Babel. So I guess he has made his share of Pull Requests.
Not at all.

One important difference here is that people are free to discriminate on almost any grounds except a narrow set that have proven to be irrational and historically devastating. Race, gender, religion, and a few other things depending on jurisdiction.

The same rules apply to YouTube. If they had been arbitrarily banning the accounts of black people, they would have lost.
What was the billionth one issued? It's a long shot, but my website had its certificate renewed today, and it would be cool to find out if I had the billionth one.
Hasura is more than just GraphQL. It maps GraphQL queries to single SQL statements. So you can think of it more as an ORM, but rather than mapping objects to the database it maps GraphQL statements.

The advantage of this over a traditional ORM is that by having the entire query up front it can be smarter about how it does the translation.

Regarding REST, this is very very different. With REST, you map a single "query," the REST endpoint, to an SQL statement (ideally one). But if you want some other query, you're out of luck. Either you make a new REST endpoint, or you manually call several endpoints and compose the data.

There are some dangers to the GraphQL to SQL approach, namely it's harder to guarantee performance when the client can execute arbitrary queries.

Now, GraphQL by itself, I agree it doesn't solve the hardest problems: getting the data for the query and doing it security. But something like Hasura does address those points and I do think it is an advancement over previous technologies.
Great question. Right now the major difference is the D2C (patient-initiated, physician-ordered) aspect. Invitae is starting to offer this to some extent but they mainly seem focused on cardiovascular and cancer. Unlike those companies, we don't consider ourselves a testing company. For most patients in the rare disease space, understanding the underlying genetic cause is really only the first step in the process and then most need tons of help navigating the healthcare space afterwards. We started with the test, mainly because of the access and affordability issue patients were having. Many of our patients have requested tools for longitudinal phenotypic data collection, connections with all of the relevant advocacy groups, further genetic counselling, efficient ways to test family members, and detailed, patient-readable information content about their variant. We try to provide everything these patients need (aside from medical advice of course) as the healthcare system isn't currently set up to help rare disease patients.
We have to prioritize, though. #1 is more important than #2 at the moment.
not cool to passive aggressively "quote" a grammatically incorrect comment clearly made by an ESL commenter
>was referring to the difficult of making -good- fried rice.

I don't really understand, just fry your ingredients at high heat and don't stop stirring. Make sure the pan is hot before you add oil, make sure the oil's hot before you add the ingredients. Start with the meat/protein, when that's browned, if you really want it all nice and cooked well, take the meat out and put it aside then do the onions, theb mushrooms, peppers, veggies etc. Garlic and ginger and stuff last, re-add the meat, add your cooked rice, maybe an egg at that point and keep stirring until it's nice and golden brown.
I fear that "do you want to add to desktop" will end up just like "do you want notifications". Please Chromium and Firefox team, for the love of web apps, stop the modal spam! Its very useful features, but you are teaching users to ignore them.
Token solutions that make people feel good but accomplish little or often make things worse distract attention and resources from real problems and significant problems.
Why would you touch your face more often? At least you won't have a direct contact with your hands. Besides, why do you think putting on a mask and washing hands are somehow mutually exclusive?
Honestly, I took up smoking Cigars because I saw all villains smoke Cigars. Call me stupid but then a lot of people do get influenced by the bad guys and buy the products for the reason it is being used by bad guys.
I suspect the separate burner is a better approach.

People use such torches for other things though (e.g. sous vide, but usually with a deflector); I don't know if it's really a risk. I haven't tried it just happened to see the article a few days ago and remembered.
I read the article, thank you. It's you who have misread my comment. I was praising the article for illustrating good principles of visual communication, and lamenting how there are so many people making data visualizations out there that don't understand this stuff.

P.S. From the HN guidelines (https://news.ycombinator.com/newsguidelines.html):

> Please respond to the strongest plausible interpretation of what someone says, not a weaker one that's easier to criticize. Assume good faith... Please don't comment on whether someone read an article.
At last, I'm very pleased to see a native editor for a modern language like Golang, unlike the unpleasant experience I've had with VSCode and Goland which perform very poorly on my Macbook with other Electron and Java based software running.

I'm also switching back and forth with CodeRunner which runs great but has poor support for Golang debugging. If Chime adds support for a better build, run and debugging experience, it could be my 'goto' editor for Golang. I wonder if Rust could have the same treatment for a dedicated editor, perhaps.

I paid for CodeRunner for the same quality and features and if building, running and debugging features works on Chime, that would be a direct purchase from me. Thanks for your work on Chime!
Yes, right now, we offer only in the US in all states except NY.
> even though most businesses are fast at reacting to global events and responding accordingly

Citation needed. I wont declare the govt to respond quickly, but the incentives, experiences, and expertise at companies dont tell me they are likely to respond in the best way. Some, certainly. Many? Maybe. Most? Prove it.
I am using https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.h... as an 'at a glance' overview
It's not like they're removing it. They'll just push an update and your extensions will be gone.

A lot of corporate communication wizards might be required to dress this up as something else than direct removal.
They appear to be. Only a handful of PragerU's videos are marked restricted. A cursory check on https://www.youtube.com/user/msnbcleanforward/videos with restricted mode on and off shows a handful of their videos are also marked restricted, for example:

https://www.youtube.com/watch?v=KZWasc1rC_U

https://www.youtube.com/watch?v=TSFQos3XTEQ

https://www.youtube.com/watch?v=2ZWtdFVU904
Hasura and Postgraphile both use row level security for access restriction. Anyone can still execute a query, but they won't get back data they don't have access to.
Straws are likely the same deal, plastic straws are probably more environmentally friendly than their metal straws.

No, they're not. Full stop. It's not just the production of the straws that matters, it's their post-use effects. They can choke birds and fish, pierce stomachs or guts, and eventually become microplastics that get eaten by plankton and fish since the plastic doesn't degrade on a timeframe relevant to human or even generational lifespans.
DNS challenges are great for internal services too, where you want server-to-server communication to be encrypted but the servers aren't accessible over the public internet.
I still get a kick out of the fact that stereo Bluetooth cassettes exist :)
Who else provides free ACME other than let's encrypt?
Got it. No idea if those accusations are true or not but that is at least a potentially valid reason to ignore Imperfect as an effective solution to food waste.
"if people fear this new virus so much, shouldn't they also fear the flu virus every year?"

People should definitely be more concerned than they are about the flu every year.

Way fewer people would die from the flu every year if more people took it seriously and got vaccinated. Some people get vaccinated, but not nearly enough. Also, every year many people continue going in to work (even if they can take sick leave) when they feel sick. That spreads the disease and increases the risk that other people will die.

Fortunately people are starting to wake up to the risks of COVID-19, and will probably change their habits (by washing their hands more and staying home when they're sick) to make the spread of both diseases less likely. Unfortunately, after the outbreak is over they'll probably go back to business as usual in respect to the regular flu.
> Kudos for making it so easy. If PWA is the way forward, then services
> like this will help accelerate adoption.

Thank you!

> On a separate note, how many users know about or bother to “Add to
> screen”?

PWAs are relatively new. Not many users know about installing them yet.
But that's changing. See the install flow videos here

http://i.imgur.com/vVoDtbW.png

to see what installing a PWA looks like from the users perspective.

> Can the number of users launching from the home screen be tracked?

Definitely.

In the PWA's manifest, you can specify the `start_url`. This can include
a sentinel to differentiate a PWA launch vs a browser session, eg

"start_url": "/?launch=pwa"

That's actually a great idea to add to Pep. Kudos.
I've never used a 3rd party food delivery service. what makes it so bad?