skysight-inc/HackerNews huggingface dataset:
Something interesting I stumbled upon recently: https://en.wikipedia.org/wiki/Aldehyde_dehydrogenase#Patholo...

Specifically these quotes:

> Some case-control studies claimed that carriage of ALDH2x2 allele was a risk of late-onset Alzheimer's disease independent of the apolipoprotein E gene (the odds for LOAD in carriers of ALDH2x2 allele almost twice that of non-carriers). Moreover, ALDH gene, protein expression and activity are substantially decreased in the substantia nigra of Parkinson's disease patients. These reports are in line with findings implementing toxic lipid oxidation-derived aldehydes in these diseases and in neurodegeneration in general.

> The ALDH2-/- mice display age-related memory deficits in various tasks, as well as endothelial dysfunction, brain atrophy, and other Alzheimer's disease-associated pathologies, including marked increases in lipid peroxidation products, amyloid-beta, p-tau and activated caspases. These behavioral and biochemical Alzheimer's disease-like deficits were efficiently ameliorated when the ALDH2-/- mice were treated with isotope-reinforced, deuterated polyunsaturated fatty acids (D-PUFA).

D-PUFA is interesting (and being investigated for use in other diseases, e.g. Huntington's) but it's just addressing the proximal cause of the neurodegeneration (= the build-up of peroxidation products in the brain) rather than the mechanism by which those products are produced.

I'm much more curious to know whether introduction of exogenous ALDH2 into the body (perhaps above wild-type expressed levels of ALDH2) might be neuroprotective/prophylactic against neurodegenerative disease. As far as I can search, though, nobody's ever even extracted+purified an ALDH2 enzymatic solution, let alone tested it for such effects.
Shoelaces. Without them we'd be tied in knots.
Amyloid plaques are clearly not the problem, but I thought we already knew that? When did these experiments get launched?

There are people who appear to be genetically immune to Alzheimer's yet build up massive amyloid plaques. They do not show any symptoms of the disease, so shouldn't this have been ruled out by now?
I think Boeing is getting smacked in the face by a change in pilot skill levels and areas that has been happening around the world since the 90's.

Boeing is in a really bad position to specify minimum training requirements, since any time they ask for more training requirements of their customers, the customers ask for more money back. So its good that the FAA wants to enhance training requirements.

Based on some of the things that have happened around these two accidents and others recently, I think the increased training should encompass more core skills as well.
All here for free: https://www.epubbooks.com/series/1-voyages-extraordinaires

Registration required, though.
"What's the best way to kill a reddit thread?

Just make it a year long thread and wait for the year to end." -- circlejerkGPT2Bot
But how real are the "good vibes"? The impression I get is a lot of the time its all just a facade.

When taken to the extreme you end up with a Potemkin village where everyone grins and nods and goes about their day never expressing anything honest.

I much prefer a society where people are open and there is some accountability than a group of smiling yes men which is the type of thing these corporate culture workshops seek to indoctrinate.
Your friend should start with a project in mind. Even if they fail, it will guide everything else. First thing they need to find out is do they have any talent, or equivalent amount of burning desire, etc. Programming is hard, and not for most people (imo.) Supplementary income is one of the worst reasons to do this, but understandable.
Will there be a whitepaper pertaining to T-NLG? Post is light on details.

Also, what's the timeline to release private preview? Outside of academia, who else will you likely be working with first?
The free snacks help with morale, and cost the company very little. Personally, I'd rather have more money so I can buy my own snacks, but I've never heard of a company offering employees an actual choice between free snacks or a raise, so in reality it really comes down to free snacks vs. no free snacks.
Thanks, that's good to know. In Oceania (Australia/NZ/Pacific Islands) you can get what's called a frozen ATPL upon completion of all the necessary theory exams. You qualify to attempt the practical flight test to get a full unrestricted ATPL upon completing 1500 hours of (AFAIK) multi-engine jet time.

You need an unrestricted ATPL to captain an airliner, and as a first officer on flights longer than X hours (where the captain is expected to leave his post to rest at some point).

Source: not a pilot, but friends with a couple of them.
Meanwhile, Levi's 501 still pretending like 1851 didn't happen
Also this, for free: https://fr.wikisource.org/wiki/Auteur:Jules_Verne
"Google wanted leverage over the carriers to bring Google products to feature phones more easily."

"Google products" is not how another knowledgeable HN commenter recently put it in another thread.

He said Google created Android to make Google the default search engine on phones.

A commenter on the tbray.com page says the same thing.

Given Google's line of business, online ad services, the cumulaitive search traffic sent to google.tld as a result of being the default search engine easily outweighs whatever value could be generated from other "products". The OS might be loaded with interesting things for users and industry commentators to "review", however nothing could be more important to the company's bottom line than search traffic to google.com. If that traffic were to die down, the company would be in crisis mode.

An entire OS created just to be the default search engine. Was this the first time this was ever done.
There's no chain stay, to complete the rear triangle.
O/T for inventions but:

I'm American and have lived in Germany a lot. In the 1970's in California, we learned to write with pencils.

By the time I was in high school and used pens (mostly ballpoints, some felt-tipped) and also typewriters, I thought of myself as a pretty serious stationery nerd.

Then I went to Germany and everybody at school used fountain pens, which I didn't even know how to fill! People probably thought I was an absolute barbarian, sticking to my ball-points.

Then came university: in America, at the end of the 80's, you would be considered rather unserious if you didn't at least type up your assignments. Computers were an option but the minimum effort was to type things, libraries had lovely quiet-ish electronic typewriters for that purpose.

And back I went to Germany, where -- at University! -- everybody was writing everything with those same damned Füller!

And now, in 2020, at least the kids still are. Drop into any McPaper[0] and you will see a ton of cheap plastic fountain pens for the school kids. (Fortunately for me, the roller ball has also taken pretty firm hold, and people don't look at you funny anymore for not carrying around an ink bottle.)

I have a really nice fountain pen, a Pelikan[1], and I almost never use it because I can't commit to thinking about the ink that much. In the end, the Germans out-nerded me.

[0]: Really, there's a chain called McPaper: http://www.mcpaper.de

[1]: https://www.pelikan.com/pulse/Pulsar/en_US_INTL.Core.display...
Biogas reactors

Silage

Pads/Tampons

Wearable Pedometers and Heart Rate sensors
What truly makes the language general purpose isn't really language features. The vast majority of languages are "general purpose" by that metric - but you don't see people writing desktop apps in, say, R or PHP. It's the libraries. Python embraced "batteries included" a long time ago, and then there's everything on PyPI on top of that.

With a language like Julia, it's going to be a chicken-and-egg problem - so long as people are using it mostly for scientific computing, the stable and well-maintained libraries for it are mostly going to be about that.
this post was also posted but the author on lobste.rs, where I've previously noticed a slightly anti-HN atmosphere. So I'm guessing the author feels the same way. (that's just a wild guess, I'm most likely wrong...)
Bear with me for a moment: I firmly believe that in order for good .com domains to be available for a smaller price the registry fee should be far higher.

The reason for that is speculation: even though a .com registration is dirty cheap, getting a decent .com domain is very expensive because for many companies it is worth it to keep the domains parked, and when someone wants to buy one of them it gets very expensive - quite often it costs thousands of dollars.

However, if registration prices went 10x overnight these domain hosting companies would be forced to get rid of many "second class" domains, which would be soon available for regular users without intermediaries. Off course "premium" domains would still be expensive, but it's an advancement anyway.
> The US has essentially on omnipotent traditional military force that can either engage or assure mutual destruction of any opponent on the earth.

Omnipotent and "assure mutual destruction" are contradictory if you think about it. MAD ( mutually assured destruction ) resulted from a lack of omnipotence. If one was omnipotent, one wouldn't require MAD.

> As we've seen predicted for 20+ years and demonstrated in the public space for 10...

Who is "we"?
> You do realize, that Russia and China are different nations?

I'm sure he does. You've been introducing several confusions into this subthread, and the above is one of them.

If there's been any national confusion on this topic, it's been between the Dutch and the Americans.
I can uderstand announcing this without code, but without a demo so anyone can try it in different scenarios?
To add to that, it is better to explicitly point out disagreements with previous experiments. That shows that you have read the literature, seen that it is in disagreement, and are willing to stand by your measurement. Not pointing it out comes across as there being something to hide, and that the disagreement in the measurements is being snuck past the reviewers.

Overall, you are absolutely correct that reviews are a really weird social context.
When I said "previous GRU indictments" I was referring to the 2018 indictments against Russia (GRU is one of their hacking groups), laid out in the same way by the same American DOJ. The amount of detail they went into then shocked everyone, and made the case beyond question.

The fact that you didn't even know what country I was talking about, yet insist on continue in this conversation like you know enough to participate is telling.

Continue on lowering the value of every thread you decide to post in.
If you believe in microevolution, what do you think happens if "microevolution" continues for millenia?

And why do all the creatures (you claim were created out of thin air) as if they had common ancestors? Both physiologically as well as genetically?

To quote Dobzhansky: Nothing in Biology Makes Sense Except in the Light of Evolution.

Why Evolution is True by Jerry Coyne might help you resolving that last part of the puzzle.
> By definition, viruses aren't alive, and amoebas are.

Interesting, I thought we don't have a definition for "alive".
In what way is it superior? I can spot several logical contradictions, just like with samples from GPT-2.
Google’s head of HR to step down
Jules Verne was generally seen pretty well in the former communist countries, my HN/reddit nickname is taken from a Soviet TV series based on one of Jules Verne's books [1]. Mind you, I didn't even live in the former Soviet Union, but when I first saw a glimpse of Verne's universe as a 7-year old kid I was hooked for life.

[1] https://www.imdb.com/title/tt0088635/
That's a code smell. 99% of components in a project should rely on props.
and other people write blogs. you exist, secondbreakfast. you exist. i read your post, therefore i exist too.
I assume no then, so just stop misusing python package manager and stop blaming distros for it
Given that the US and China are both permanent members of the United Nations Security Council, any vote would just be vetoed though right?
I spent years with Immutable and discovering Immer was a game changer. Can't recommend it enough.
Here’s the source code (or at least comments about the assembled op codes) to the example program: https://github.com/trebonian/visual6502/blob/master/testprog...

It looks like that subroutine they call at $0010 has a special hook that writes to the console whenever they write to memory address $0f.
To prevent the hug of death?
> Why is there 2+ interfaces for all system configurations. 1 of which is pretty but incomplete, and the other hidden and terrible but complete?

Of all the complaints, that one I totally understand the rationale for. It's an iterative design, they simply haven't finished building the new one yet. Until they do, I ignore it.
No, this just generates diagrams from code. I think it is a pretty neat idea for those who don't like drawo.io or Visio style charts.
on the other hand, it's less of a temporal era than a technically-inept social group, the kind that take a phone pic of their screen in lieu of a screenshot etc.
It’s interesting, but I’m genuinely curious why one would use this over GNU Unifont.
Hey sarora27, Magento is certainly more of a monolith - so if you're building a Magento site you're very much building a Magento site. Shopify is similar in some respects, although their headless offering has certainly opened the doors up a bit.

The real benefit at the moment is that you can get Commerce running with the site you already have - you don't need to replatform in order to start selling things. Additionally, the cart is entirely real time - so a user can go from their laptop to their phone without needing to refresh the page to see any changes to the cart. Finally, the core of the cart is vanilla JS - so there is no inherent need to use React/Vue/(enter JS framework here) - although you certainly can by hooking directly into the API if that's where your tooling is at.

It's also ready to rock for static websites - no backend required - that was the initial drive for the product itself and it's grown from there.
Now you're assuming they're all bad songs, and you're also making the ridiculous assumption that every song someone writes is supposed to be good. The whole point of practicing songwriting is to get better at it.

Stop being a jerk for a second, stop being aloof, and try to consider that I might actually know what I'm talking about, that I actually might be a decent musician. Your attitude is just toxic and mean.
Antiseptic handwashing wasn't false. His theory for why it worked was; that theory was that "cadaveric particles" --- literally, corpse particles, and very specifically not a more general concept of microscopic infectious agents --- were to blame for ailments, and that chlorinated lime was the only way to get rid of them. Other doctors noted things like ailments in patients with no plausible contact with cadavers, to no avail: Semmelweis was insistent.

Semmelweis is, to me, an interesting story about how it's not all that useful to be right if you're unable to persuade, and Semmelweis' difficulties with persuasion have little to do with his adversaries bloody-mindedness and much to do with his.
Tiling window managers are a great way to fiddle with window arrangement LESS not more. Shoving terminal windows between other windows for spacing is spacebar heating. I3 has a branch with the feature required its called i3-gaps. This feature is on its way to becoming a part of mainline i3 but has been available for about 11 years now as a separate package.

https://github.com/Airblader/i3

The setting

smart_gaps inverse_outer

Would give you a configurable empty border only when you have a singular window ensuring that the single window isn't so large as to be hard to read comfortably.

As far as windows being too small to read comfortably I'd advise you to place no more than 2-3 windows per workspace. For the benefit of those who don't use i3 workspaces are per monitor.

Given 2 monitors you can easily show 4-6 windows which is easily enough context for about any task.
Sure, I'll post another comment to this one hopefully this evening with a couple tracks. It's been a busy day.
I sort of agree, however there are ways to print metal parts via a sintering process, and if your printer doubles as CNC to cleaning up critical surfaces even better. They just cost a lot of money, but that is changing, just like 3d printers becoming cheaper as the required parts become common commodities.
> google.com is ad supported. I pay a ton of money for Windows.

I am the OP who called on Microsoft to stop this.

That being said, they upgraded me to Windows 10 for the low cost of $0.
If this is success, I'd hate to see failure.
Why didn't you use gaps instead of empty windows? Instead of hours writing scripts you could have spent 10 seconds adding a few lines of config.
You can assume whatever you want, and I'm not blaming anyone, just telling you what reasons people have for using one distro over the other. You're arguing with the wrong person for the wrong reason.
Crucially also, convnets have exceeded human performance on several important vision tasks.
Trends in Functional Programming (TFP) 2020 Proceedings
Don't forget about very smooth roads, without which you would want even more technology.
This book should be called The Misinformation. It omits crucial safety information and other details about many of the processes it mentions, and the author doesn't maintain a public list of known errata; it's entertainment, not education.

Three better alternatives: the Primitive Technology channel on YouTube, the Boy Scouts Handbook, and Wikipedia, which you can download as .zim files for offline reference. Other relevant YouTube channels include AvE, CodysLab, and Applied Science; in more specific areas you have NileRed, Abom79, Ben Eater, EEVblog, This Old Tony, GreatScott, ElectroBOOM, and NurdRage. Unlike the book you're recommending, they are by people who know how to do the things they are explaining, show their errors, and include the relevant calculations. There are other channels like How To Make Everything and King of Random which do not; they are entertaining but deadly.

General-purpose know-how books have gone out of fashion, though we still have the CRC Handbook and the Machinery's Handbook. In the 19th century there were a bunch of books like Dick's Encyclopedia of practical receipts and processes (ripped off, I think, from Cooley’s, or possibly vice versa) which covers a wide range of topics at a level sufficient to enable you to practice them; you could probably build a fair bit of Victorian technology from the recipes in Dick’s. (You aren't going to get a loom out of it, though; for that, see The Mechanism of Weaving, but YouTube is far superior.) I think the equivalent is more difficult to-day.
I have a friend who's into fountain pens and for a while worked for a company that sells really nice ones. In that capacity he came to know some people who collect pens.

You'd be amazed. One guy I heard of -- not-famous founder of a very famous brand -- was so into it he'd spent tens of millions building his collection, but outside the world of serious pen enthusiasts it wasn't "worth" anything near that much.

A lot of the pens one collects are very limited editions but otherwise unremarkable: say a really good pen that would cost $500 but in a different color and they only make a thousand of them in that color and it costs $10,000. (Made-up numbers but $10K is not that much in the pen-collecting world.)
Supposing that a random word generator is a worthwhile source of valuable knowledge, and if you're willing to concede that Lacan is/was just as good as a random word generator, then YES, Lacanian psychoanalysis is a valuable epistemological framework.

But

> a random word generator is a worthwhile source of valuable knowledge

Is obviously valse!
He's not wrong. I'm off about four years now, and the only thing I miss is snapshots of everyone's kids.
Sure, this shows robots good at more or less fitting the formula for various types of typical articles or posts. Still, things that make no sense accumulate over sentence or paragraphs, depending on how formulaic a given format might be. So this simultaneously generally impressive but not useful for any one thing.
Yeah, same here.

Like, what's the point of an "operating system UI" in a Linux desktop environment?

But then, I also don't get the point of doing that in some game engine called Unity.

I mean, is that a viable way to do a desktop?
Go proposal: error passing with “pass”
for the most part, these days, if you're on the internet you are the product.
The Huzita-Hatori axioms are at the core of thin-sheet origami. In turn, mathematical origami is hot stuff, not only because of its applications (folding automotive airbags, designing mirror & solar panel assemblies for spacecraft) but also because it's opening up novel areas of mathematical research.
That produces a Security Council deadlock that then opens the door for General Assembly action under the Uniting for Peace resolution, as has happened roughly a dozen times since UfP was adopted in 1951.
Xfce4 Whiskermenu 2.4.0 Greatly Improves the Alternative Xfce Desktop Menu
>> i definitely want people to read in a format comfortable for them

>> i also know which rules don't matter

Are you sure? These 2 statements conflict in this context.