skysight-inc/HackerNews huggingface dataset:
>
This drug costs more than $10,000 per year because it is an orphan drug. There's little to no money spent on marketing for this drug. None that I've ever seen and I'm the target market for it. The net margins for the pharmaceutical company that manufacturers the drug is now around 20-25%, but their net margin was very very deep in the red for the first ~6 years that I took the drug. Not sure if they have yet recouped the investment from the 7+ years that they were in the red.

If it's an orphan drug, treating a rare condition, the economics of it are by nature difficult, because of the high fixed costs, and the low maximum revenues.

Since international medicine does not follow the same model as international aviation, it's not surprising that the high fixed costs (In time, research, and money) of adopting a new medicine + low, variable returns (Most countries are much smaller, or much poorer than the US), it's not surprising that the world isn't jumping on this head-over-heels.

Do you need this drug to live? If not, is it a marginal or significant quality of life improvement? If one of the latter, its possible that the cost/benefit analysis for it isn't great, and its manufacturer hasn't even bothered to go through the approval processes for other countries.

> It's not foolish if you're the one whose life is bettered by the medicine in question. How my healthcare dollars are spent is my decision, not the government's decision.

I'd like to decide how my military, policing, and grade school education dollars get spent, too, but there turn out to be exceptionally good reasons for why they should be spent collectively.

> You're not the one paying the price for putting the decision in the hands of a bureaucrat. I and people like me are paying that price.

Everyone will at some point need healthcare, so yes, I do pay the price, and I'd like a system that does its best to get good results for money spent.

And if your insurance is paying for this drug, keep in mind that some unelected insurance-company bureaucrat has done a cost-benefit analysis on it, and decided that they were going to pay it. They could have gone the other way with it, and decided that it was not covered by insurance. As someone who buys into health insurance, but does not consume much healthcare, I can use your same argument to argue that my hard-earned insurance money should be spent on me, not you.
MiDI 2.0 is not isolated? Crap. Literally any of my guitar pedals when connected by USB instantly injects noise into my electric guitar signal chain, and isolated USB hubs are practically non-existent.
You might want to check out "Unix system programming with Standard ML" by Shipman. The first half of the book covers the basics of SML and the Posix & C interfaces, and also discusses building a simple TCP client and server. The second half of the book is a larger project building a web server:

http://www.mlton.org/References.attachments/Shipman02.pdf
> They lost $800 million in 2019.

You're not wrong.

Of course the counterpoint is that they were profitable both the 3rd and 4th quarter.

> They still have increasing bills and huge liabilities.

That is true. However, some of their debt will convert into equity as long as the stock price remains where it is.

More broadly, I'm not trying to convince anyone that Tesla is some sort of value stock. It's not.

It's absurdly volatile. There's also a good chance that they won't win the race to level 5 autonomy.

All I'm saying is: enough people believe in the upside and think the downside has been diminished sufficiently to drive up the price to where it is.

Maybe they're wrong. Maybe they're right. I certainly don't know.
"faster (300 mbps) Ethernet"[1]

[1]: https://www.adafruit.com/product/3775
What Is the Healthiest Diet?
There is a section on motivation in the blog post (it literally has "Motivation" in the title):

> A number of clients already exist for the XMPP protocol, however Dino sets a different focus. Existing clients target tech-savvy power users. The XMPP ecosystem lacks a client that is enjoyable to use while providing the features people expect from a modern chat application. Dino fills that gap by aiming to be secure and privacy-friendly while at the same time providing a great user experience.
This strategy is taking a page out of the very successful cannabis legalization movement. First there are decriminalizations at the local level. This makes decriminalization at the state level much more palatable for politicians, who see there's political will at the local level to make it happen. Once the first state decriminalizes it, others states will find it easier to follow suit.

Apart from voting, you can also donate and volunteer, but some of the best things you can do is educate yourself and others on the responsible use of psychedelics. If taking mushrooms or other psychedelics has helped you in some way, tell others about it. Seeing people who have their act together, who admit that mushrooms have helped them will open people's eyes to their benefits and make it less likely that they'll react with dismay or disgust at the suggestion that "drugs" be legalized because they equate use with abuse.

Stepping out of the psychedelic closet is not always easy, but it has to happen (as it did with admitting cannabis use) before there's widespread acceptance of psychedelics.
The solution was for all the shells to be spherical patches with the same radius (75.2 metres - not sure if that's internal or external).

That's what these sentences are getting at:

But now it struck him that as they were so similar, each could perhaps be derived from a single, constant form, such as the plane of a sphere.

By finding the parts of a sphere that best suited the existing shapes of the shells, each new form could be extracted.

The advantage of that is that all the shells can be built by assembling some number of identical parts. If you have a small tile whose curvature is 1 / 75.2 metres, then you can cover all of the shells with those tiles [1]. If you have a section of girder whose curvature is the same, you can support each shell on networks of those girders.

[1] Okay, so you might need two shapes of tile to cover the surface, although if you're prepared to do some trimming you can get away with one!
The comparative advantage of certain investors (Bob in this case) is useless if the loans are the result of fraud. I can create a fraudulent loan originator and crank thousands of loans that are worthless, simply because borrowers can't or won't pay the loan. These loans can be classified as AAA, but it doesn't matter. This is essentially what happened in 2008. And to complete the picture, nobody knows who is who, because of the widespread fraud, so while some borrowers will continue to pay, there is no way to know how many, and therefore no way to value that asset class. So, again, the problem with the failure of CDOs is not just its theory, but assumptions about the trustworthiness of loan originators.
How exactly do I run Visual Studio Professional on an iPad? Desktop developers exist too, you know.
Monetization. Native apps provide app & in-app purchases seamlessly integrated in the platform. Web payment solutions are clumsy in comparison. Sure, there are new APIs that ask for CC number, holder etc. to be prefilled but the friction is still not at the same level IMO.

You need to pay the cut to Apple/Google but in certain scenarios it's preferable than asking for payment details.
This is true, but it doesn't solve the problem. If you give Docker half of your overall resources, it's just going to take Docker twice as long (most likely longer) to finish running the test suite or whatever you're doing in Docker. The crux of the problem is that Docker for Mac has pathological cases, probably involving host-mounted volumes that are big or overlaid or something else that we were doing; the containers can be near idle and Docker for Mac consumes 70-100% of its CPU budget (presumably doing volume/filesystem things).

Note that a little Googling reveals that this is a pretty common problem.
What are your thoughts on the layered nature of our government and how such efforts could do better with the many layers? Take marijuana for instance. I think it should be decriminalized, and in many states we talk about it like it is, but in reality it depends on which law enforcement officer catches you. Where I live you'll be arrested by the sheriff (county), but not the police (town), depending on which officer catches you and if they like you or not, and not state patrol. And you won't be prosecuted by the feds, but the businesses you bought it from, which pay local and state taxes, can't use federally insured banks because it's still illegal even though it's not enforced. But state law might forbid the bank from making a hiring decision on someone's marijuana usage. In some ways it feels like we've made progress, but I'm still afraid to use it myself. How do we deal with this mess of rule-of-law moving forward?

I would like the idea of proving an idea on a small scale to make it easier to sell at larger scales. But honestly, being one of the first places that legalized it, we got a large influx of "undesirables" from other places that hadn't legalized it, causing problems we wouldn't have had if we weren't one of the first states to legalize it.
Why are you using a notebook and an IDE? I thought the notebook UI was an alternative to the IDE UI.
> SEC. 3. PURPOSE AND INTENT.

>

> The purpose of this article is to decriminalize the personal possession, storage, use, cultivation, manufacturing, distribution in personal possession amounts without profit, transport, and consumption of psilocybin mushrooms and the chemical compounds contained in them for any person over the age of 18, or for any person younger than 18 with parental or guardian consent by amending California Health and Safety Codes HSC § 11 390 & 11391.

I'm confused, whats the difference between legalization and decriminalization then. This sounds like legalization to me? Decriminalizaton i thought was making it a low priority to law enforcement which some places already did?
I can say it's definitely not a scam. I have personally been to multiple meetings with organizers in Oakland and San Francisco and witnessed that it is both well organized and well staffed. To my knowledge there are over 700 volunteers across the state in every county working on this initiative. Obviously, that doesn't mean it's going to be successful. I hope you're willing to risk $5 and purchase a button or sticker so you can send in your signed petition form :)
I do wish the main documentation site would focus more on Tk and less on Tcl/Tk, you get the impression that the two are joined at the hip. For those of us that don't like Tcl it seems like Tk is still quite usable but working out how is left as an excercise for the reader.

Things have improved, I found a good multi-language documentation page (https://tkdocs.com/index.html) including this good multi language example (https://tkdocs.com/tutorial/firstexample.html) but very little on how to use the c api (https://www.tcl-lang.org/man/tcl8.6/TkLib/contents.htm).

I hope things keep improving, Tk is what electron should should have been.
> real work is typically file-centric

Pilots fly planes using iPads. It’s a ludicrous suggestion that that isn’t real work.
Agreed! It’s something me (I’m the expert from the interview) and other experts have been pushing the team at Zapier to introduce.

They’ve been receptive to the idea - which is great - but no plans yet.
I'm curious how you see Tesla as "vertically integrated energy" company. You mean Tesla is going to run power plants and transmission lines? Both are highly regulated, including the price you can charge, with a very low profit margin in most cases, not sure Musk would be a fan.
A lot of people in here arguing that the iPad isn't for lesser work than a desktop or laptop, just different work. I think this is largely true, however the frustration (at least for me) comes from the fact that this shouldn't need to be the case.

With a few tweaks to the OS, and a keyboard cover the iPad could be used for all the things that iPads are currently used for and all the things that people still need desktops/laptops for. I think the frustration is coming from people who see that they're being unnecessarily constrained.

Even being able to dual boot iOS or macOS would solve the problem.
The mobile web sucks because of ads and bloated websites not because some inherent technological flaw.
Being a part of financial elite.
Looks like a nice project, but why wouldn't one use http://pidgin.im, which also supports XMPP and as far as I know is pretty solid, works well, and is also cross-platform?

What advantages does this have over Pidgin?
I have a rule of thumb I tell my friends when they ask me questions of the form "X is so lame, why can't GPM just do Y?". The answer, almost always, boils down to laws, regulations, and contracts. This is one of those times.
You Don’t Know What to Optimize Until Your Profile Your Code
You're grossly lumping all drugs into one pile. Presumably you mean illegal drugs when you say "I never done drugs", because I'm certain you've done drugs like caffeine, probably alcohol too.

If that's how you define drugs, by those which are illegal at the time, then get ready to accept psilocybin as a non-drug in the future.
The bull case for Tesla is clear. Aside from Nissan with the Leaf, who recently loss their galvanizing CEO and who's market cap has tanked since, what major automaker has anywhere near the success of Tesla with EV?

No doubt execution has been an issue in the past, but recent sales trends, completion of gigafactory, and Chinese expansion show that they are on the right trend.

Tesla's were confined to the luxury market, but the Model 3 is doing well and Tesla is being allowed to come out with more and more SKUs while the other big auto's are still finding their footing.

The branding is on point without the need to advertise, like the iPhone, Tesla's are becoming just a feature of everyday life (at least in large metro's). Finally, and this is absolutely non-empirical, I just believe in Elon. Tesla might be one of those companies that simply fades away once a galvanizing leader leaves, but as long as his heart is beating I'll hold.
"Water closet" or WC is hiding the meaning just as much as "washroom", in my opinion. Both imply a room with washing facilities.

Calling the room a toilet just sounds odd to me, because the toilet is in the room, but I understand why it's used like that.

I've also heard "I'm going to use the [toilet] facilities".
Facebook Financial Results 2019 Q4
It's never your fault that you don't get art. It's the nature of art. The purpose of art is to communicate things that are difficult or (ideally) impossible to communicate with words. This tends to be ephemeral things like emotions.

The thing about communication of this sort is that its error-prone: the "message" you receive may not be (and often is not) the "message" the artist was intending to convey. If the artist's communication style doesn't match your own way of thinking well enough, you may not get a message at all.

When that happens, that's not your fault. Nor is it the artist's. It's just a case of two people not connecting.
http://pidgin.im seems to be pretty easy. Doesn't require any tech-savvyness other than entering your credentials in a nice, intuitive interface, unless I'm missing something?
I won't claim to be very knowledgeable about ring, but I'd imagine that the difference comes down to Alexa's claim to only listen for its name, rather than sending all audio in range up to Amazon for processing (regardless of whether you trust that or not). Based on the Ring controversy, it seems all footage from the system is available to employees for ad hoc usage. Having the theoretical capability to listen isnt nearly as dystopian as the practical capability to watch.
Ya. As someone who plays acoustic piano, guitar, ukulele, and ocarina...using MIDI 1.0 to connect my electronic gear hasn't created any latency that's noticeable to me.

Sure if you're sending things to and back through a DAW or whatnot it can get noticeable, but that's processing/software time, not MIDI 1.0.

I can't tell the difference between a 320kbps mp3 and FLAC either, but I'm not worried about it.
My guess is that the "revenue streams" from reproductions of public domain content are (1) negligible to begin with, and (2) might even be higher for many institutions under a permissive policy, since paying for the institution's implied endorsement would still be a highly-sought-after signal for most serious commercial reusers. Many institutions are starting to realize this, even in Europe where these overblown copyright claims used to be even more common.
I literally didn't listen to any music voluntarily at that age and I can't say I listen to anything that was available back then, now.
Kali Linux 2020.1 released: New tools, Kali NetHunter rootless, and more
We are aiming for support for the Librem 5 and other smartphones that use a more GNU/Linux-ish environment. For Android there is conversations.im with a similar feature set.
Your coffee bean analogy isn't sound.

If someone steals a 50lb bag of beans and sells them to me, I am now in possession of 50lbs of stolen property. If I sell 25lbs of the beans before the police catch me, they will confiscate the remaining 25lbs of beans and those beans become evidence. Then I will go to jail for receiving stolen property. Then the victim will sue me in civil court for reimbursement of 50lbs of beans.

Just because you can flip something that's stolen doesn't mean it's gone forever. The victim in either case doesn't care which beans or coins they get. They just want the value of n coins. You could probably skip giving him any coins at all and just reimburse him a dollar amount for the value of his property.
OpenVPN is extremely slow, same setup with wireguard is guaranteed to be much faster.
Need testers/feedback – Global clock to eliminate time zone calculations forever
>fdupes will let you make hard links on any filesystem, but hard links do the wrong thing when you edit them or need different permissions

Hard links mostly work as you tell them to. You may need to set things up properly, but it's essentially the same thing being done.

>fdupes will not let you reconcile duplicates in snapshots on ZFS

Why not? The files are kept in a hidden folder in the base directory.

>ZFS deduplication is block-based

It is also live. You don't gain Mich with offline block deduplication over file, though it is better. Live deduplication is a feature even if unnecessary for most.
> he died due to infection from an unsanitary operation.

Actually, he was beaten (per Wikipedia article):

"He was severely beaten by several guards, secured in a straitjacket, and confined to a darkened cell." "He died after two weeks, on August 13, 1865, aged 47, from a gangrenous wound, due to an infection on his right hand which might have been caused by the struggle. The autopsy gave the cause of death as pyemia—blood poisoning.[64]"
There should be an open e-ink device and ecosystem. Even if you go through the trouble of flashing your kindle with a custom image, you're still stuck signing into your Amazon account to borrow a book from the library.

Librarians will never give out your checkout history to anybody without a national security letter or a warrant. Meanwhile, Amazon is probably passing your reading records around to 50 different analysts and storing them in databases where dozens or hundreds of engineers have access. When I go to amazon.com, I see recommendations for other books similar to those that I've read, including those that I didn't buy through their store.
I agree. They have been steadily decreasing the amount of guidance that they give out each quarter and this is another part of that.

I don't particularly like it.
I’m working on a global clock that makes time difference calculations obsolete. Why? Well, it all began a few years ago when I felt the frustrations that came with scheduling calls across different time zones. That experience has been and still is messy!

The solution here is a new clock concept utilizing a new UTC, a UTC that rotates with you according to you location on Earth. So, the clock knows where you are and adjusts itself for you. This unifies the reading of time everywhere at any given moment. Thus, time zone calculations can be eliminated.

There are 3 main features implemented with the clock:
1- Intersect: to find the best time for online calls based on office hours between different time zones
2- Range: to help users define and share their global work hours or availability
3- Location: to see the clock in different locations so to eliminate the calculation of what 9am in San Francisco would be in your local time

Other solutions out there couldn't help me, unfortunately. Almost all of them work by stacking different times zone together, which doesn't really solve the problem from the roots. Calculations are still needed in many use cases, which makes no sense. There should be one language of time everywhere, a global time. It's there and is called UTC, but the problem is that it's not integrated in our daily life. This clock does that.

The idea of the clock is to have a unified time zone that works for all locations on earth by using the same time system we all know (24 hours, 60 minutes, 60 seconds) and adding on top of it a rotating UTC layer as the global time. This layer is presented in alphabet. The reason for that is to distinguish the local time in numbers form the global one in letters.

If you like to know more details, check this 8-min-read about hTime https://medium.com/adventures-in-consumer-technology/introdu...

I'd love to hear your thoughts and feedback, thanks!
There's a word for this: provincial.

Trying to understand certain phenomena in these times (like the election and continuing support of certain presidents) can be utterly mystifying to academics, intellectuals and other mental explorers.

But it helps to realize that half the country lives outside of major cities and their biggest concerns are mostly things like whether gas prices will go up, and real estate taxes, and if they'll have a job next year. The environment or corporate malfeasance or discrimination are so far below their radar that they can be considered second-order effects. They know their way of life and they want it to stay that way forever and they're certain that they sure don't want some far off know-it-all to tell them what to do.
It took rather some poking around the site to discover that Godot is (apparently) a game engine coded in C#.

Hint for people posting release announcements: you could save a great many people quite a lot of time, cumulatively, with just a single short sentence in the first paragraph of your announcement. You probably would pick up some new participants who would have given up in disgust before they could discover what the hell the thing is.
Is it FreeAgent by any chance? I use it (but can't check as I don't have a Facebook account) and if it is that one then I will definitely be looking to switch away as this is unacceptable.
I have questions:

1. What/Who's debt is being packaged?

2. What happens if the debt holders don't pay?

3. How are rating agencies rating these?

4. Who is buying these?