skysight-inc/HackerNews huggingface dataset:
Didn't you see an "analyze this sequence" menu on the right?

* Run BLAST

* Pick Primers

* Highlight Sequence Features

* Find in this Sequence

The BLAST algorithm is an interesting read. https://en.wikipedia.org/wiki/BLAST_(biotechnology)

I can see its power even if I'm not a biologist. For example, I just submitted (everyone can use the system) a BLAST task for a megablast search to compare NC_045512.2 (Wuhan-Hu-1) and NC_004718.3 (SARS coronavirus) for an alignment, and the system is able to "diff" between the two sequences (and even has an option to visualize it in a 2D graph), and finally telling us that 82.3% of the both genetic sequences are identical (not really close in a biological sense). You can also search identical genetic sequences across the entire databases by constructing a more complex query.

Here's my result: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Get&RID=2MDW41R...

And apparently, the specific algorithm used to produce my result is described in this paper.

> Zheng Zhang, Scott Schwartz, Lukas Wagner, and Webb Miller (2000), "A greedy algorithm for aligning DNA sequences", J Comput Biol 2000; 7(1-2):203-14.

http://pipmaker.bx.psu.edu/dist/greedy.pdf

It looks like a simple algorithm, which can be implemented for fun as a weekend project. One can run one's program on real DNA sequences, and compare the outputs with NIH's implementation. Don't forget to write an article and submit it to Hacker News when you're done. Biohacking!
What is your take on link to Parkinsons and Alzheimers from therapeutic doses of amphetamines 60mg and below daily?

Am I trading my future brain function for quality of life improvements in the current?

The thought of irreversibly damaging my dopamine transport system later on in life feels like I am making a deal with the devil every time I take a dose of stimulants to correct my dopamine imbalance and cognitive deficits to feel neurotypical for a fleeting period of time soon after ingestion.

Any link to hemorrhagic stroke later in life as well? Thanks for you time.

Thoughts on any neuroprotective measures I can take now like memantine or bromocriptine(sp?)?
Introducing The Linked Commons
Governments are made up of people capable of good and evil just the same as private companies. If we’re simply going by the historical record, governments have committed some of the world’s greatest atrocities in the name of certain genetic theories.
Which form of abstract grouping of people is the most trustworthy?
They're loving it though. Bots push something to trending, real people end up talking and sharing like crazy. Their KPIs since this last election must be insane.
"The sales executive hired a stripper as a Subsys sales representative to help persuade doctors to boost prescriptions. The woman, named Sunrise Lee, eventually was promoted to oversee a third of the company's sales force."

This is begging to be made into a movie.
By vterm do you mean this?

https://github.com/akermu/emacs-libvterm/blob/master/README....

It seems extremely experimental, and I've been trying recently to make my emacs more stable so I can choose when I want to spend time editing my config.
It's really hard to ignore the conflict of interest here. All of the company's research suggest it works, and the only other research mentioned in the article raises flags.

Call me skeptical.
I did that for a while but ended up buying a gaming PC for about $1000 and talk about a night and day difference to my $2000 Macbook. 100x the catalogue of games and 5x the performance.
It may not be much easier than your setup, but my fiancée and I have a shared Simple account that we both deposit $x to each month and then withdraw shared transactions. They make moving between shared and individual Simple accounts pretty easy and allow bucketing money into categories, which we use for various budgets (travel, restaurants, groceries).

For us, we like that the budget is tangible. There is only so much money we can withdraw from it, which helps us avoid blowing through our budgets. It also works well with the way we split costs. I make more money, so I put more into the pool every month, but other than that we don't need to think about it.
That's the point. Separate the "smart" components, which are short-lived and at the whims of the manufacturer, from the "dumb" components that are not at the mercy of constant updates, online accounts and sunsetting. You can connect to Shopify from a chromecast, airplay, bluetooth from a phone or anything else yet to be devised.
Realistically the 32-bit abandonment in macOS Catalina significantly damaged the Mac gaming market (however “justified” it may be from an engineering standpoint, with many years of warning, etc.). There is simply no good way to tell people that the vast majority of games they probably acquired in the last few years are unlikely to run on any recent hardware.

Some games do move forward to 64-bit but it will certainly require several years for the Mac game market (such as it is) to recover even to the point it had reached.
IMHO what you are saying and accurate diagnoses which result in positive-to-lifechanging treatment are not mutually exclusive. There's always more than one way for a thing to go wrong ;). And I'll check that book out. There's an interesting book on addiction, based on studies on rats, arguing that addiction is usually a coping mechanism for an unhealthy environment. Again, I don't think these different things are mutually exclusive.
How do you guys do the importing? (Specifically do you use a bank API service such as plaid?)
Bootcamp is the only real answer on macOS right now when it comes to 3D - that includes more than just gaming. Now I just have wait and see which one will happen first, AMD actually comes out with a high end video card or nvidia and apple work out their differences.
Would you say that the proverb still encourages the reader to do the thing in the near future? Sooner rather than later?

Or does it simply suggest to pick the best time that is still available?
What about neon brown? Definitely much worse.
I down voted because I believe it is an extraordinary claim without evidence.
This is awesome. If you haven't already written about this, you should, because I'd love to read about it.
Having some turnover is expected and accounted for. It varies by industry, but in tech it's pretty high at usually around 12-13%. The problem is when a company's turnover rate greatly exceeds the industry norm because it means 1) they're spending a lot on employee acquisition, training, and efficiency loss due to knowledge leak, and 2) there's probably one or more bad reasons why so many more people are leaving the company than is normal.
Perhaps its changed since you looked because my fiancee is Latin American and her results tell her the provinces/areas of her home country where her extended family is originally from.
Probably not working on it during work hours or times when people expect you to work, as well as from not within any company property. If you work on your project on weekends from the comfort of your own house or a coffee shop, that's cool. If you do it during lunchtime at work or on the company office property during weekends, that is a bit shadier, even though realistically there should be no difference. Try to make your personal project situation as clear-cut and separated as possible.
You have been eaten by a grue!
The addressable market for Mint is people that want to track their budget. They maxed out. Their only revenue model is giving you leads for credit cards based on broad categories.

---

With a little more data it would be amazing. Just forward your Gmail to it and it would line up all your receipts with all your credit card purchases. Now its revenue model is Honey and giving you targeted adds for competitors to specific SKUs it knows you are buying.

---

Who would be dumb enough to give all their emails to this type of company? I don't know, but there are piles of people that give out their bank passwords to "validate their accounts" with Plaid. So maybe it is not too low.
When was the last time they actually released a game though? From Wikipedia I can see:

Nov 2018 - Artifact (Collectible card game on Windows/Linux/MacOS)

Apr 2016 - The Lab (Windows only)

Dec 2014 - Left 4 Dead: Survivors (Arcade game?)

Oct 2014 - Counter-Strike Nexon: Zombies (Windows only)

2013 - Counter-Strike Online 2 (Windows only)

Heck even their new tentpole title Half-Life: Alyx is Windows only. Those aren't really big Linux credentials to boast about.
>Any idea which specific technologies they are referring to?

The epic games store.
Founder of Lunch Money (https://lunchmoney.app) here– thank you everyone for the mention!

For those who haven't heard of Lunch Money, we launched originally on Show HN back in October 2019. I'm a solo founder and this is my full-time job. My motivation is to create a non-opinionated, delightfully simple to use personal finance tracker. We are a subscription-based service and I don't intend on ever selling ads. My intention is to keep this an indie product and continue improving for our small but growing user base.

If you have any questions, feel free to reach out to jen@lunchmoney.app
> "Your gut biome changes all the time."

I don't think "mail us your poop" will ever be more than a niche.
Clubhouse Raises $25M
Which makes it a non-starter for any multiplayer games using EAC and Proton/Wine, and it would be unlikely to see a native Linux game using EAC considering Epic lack of interest in Linux.

They're the new Nvidia of the Linux world.

Hopefully a more crossplatform anticheat tool is available..
Acctually there were recently strong rumors Apple is going to do just that. Makes sense that Apple sees the growing gaming market and wants to get in on it. Them entering the market would be the incentive devs need to make their games work for Mac (and hopefully therefore Linux)
> I'm somewhat of an artist and I derive a lot of joy from others enjoying my pieces ...
> I think I'd give people who put in enough time to figure out how to solve a weird new problem the benefit of the doubt that they want to share it because they find it cool and you share things you think are cool.

Ah. That's a helpful way to frame it. Now that you put it that way, I think can understand it, it just seems distant. I can see that I'm not wired that way. Example: I played music in various bands for about 20 years, and for me it was about that shared experience of flow, locking in with the drummer and the guitar player and feeling like the song was in control, not us. But for other members of the band(s) it was about being on stage and hearing an audience cheer that drew them in. Same experience, totally different perception.

Of course, it appears at this instant that I am sharing with you (a stranger) my thoughts (because I think they are cool). So perhaps I simply literally do understand what you are saying by evidence that I'm doing it. /head explodes/

Provocative response, neltnerb.
How about Dollar General brand? https://www.youtube.com/watch?v=Js94bcbt5nU
The fact that Yang's campaign is struggling should throw cold water on the notion that this kind of thing poisons the political process.

It remains to be proven whether an armada of Twitter bots can change anyone's mind about a candidate. In the absence of evidence, the claim should be rejected and we should look for simpler explanations for political ills.

The more likely explanation, and the one loathed by those who still can't accept that the US elected the current president, is that things like Twitter bots and fake Facebook ads are just sideshows.
I am not conflating the two. I'm asking for the person posing the question to do the most basic research themselves. Their questions clearly indicate they haven't done so. So I opt out of continuing the conversation.

My objective reality is that they're not interested in actually having a conversation, but instead trolling. I require proof of work that that's not so.
>> But can't my employer assert that they bought all my time when I signed up to be an exempt employee?

> No, that would be illegal in pretty much every state, except possibly the worker-hostile US Deep South.

A friend of mine had to put his PhD on-hold when the company he worked for was acquired by Oracle, while his lawyer and their lawyers argued over whether the "standard employment contract" he was being asked to sign prevented him from publishing his thesis as required by the university to complete his PhD... A face value reading pretty much claimed "everything you think while employed by Oracle becomes IP exclusively owned by Oracle", and his new manager, their manager, and several levels up the corporate hierarchy all stuck to that interpretation for months before granting what was desc ribed to them as an "extremely unusual one-time-only expemtion which you musty not disclose to any colleagues".
It doesn't say how, but says there's a $500 fine and lists RCW 49.60.040 as the law.
Yeah, and from any drinking fountain or food place if you ask.

The reasoning I heard was that people using it for water were also wasting a ton of ice and the machines would run out faster than they could be replenished. It did use to be common to see mountains of dumped ice in the dispenser so I do kinda believe it.

Ideally the park should be installing those water bottle fountains.
There's always moltenVK. I can't seem to find anything that's made with it though.
Time check: Examining the Doomsday Clock’s move to 100 seconds to midnight
Anecdote to that:

I was involved in a project where we had to measure certain changes in the ground and the climate above.

The station which measures how much the ground has moved broke.

We didn't know what broke, so we called the company as we had already invested quite a bit in a new software from them as the old one had issues with the server.

Instead of replacing the whole station(without any sensors, just the base station) for around 2000€ we send in the "CPU Core" and got the newest version for around 600€ I believe and it works fine.

Keep in mind that the station was brought about ten years ago, and thanks to the new client side software still works fine with windows server 2016 and beyond.

Why can't we have that in things like this in other parts, where space and energy efficienty is also not that important?

I have the feeling more and more api,software and hardware change are just for the sake of changing and not for any benefits.

Edit:
Wording/formulating
They've had an autochess game in early access for a few months. It officially comes out next month.
It's all context specific. I would eat magenta cotton candy.
This is why the TARDIS from Doctor Who is called Time and Relative Dimensions In Space.
I don’t have really any remotes at all for this setup.

The amp I bought [1] has a volume dial for each channel, one speaker is wired per channel.

I walked around the house one day to normalize the perceived volumes from each speaker. I’ve never touched the volume dial since. I don’t see the point of wiring volume controls in the walls of each room. I can control the AirPlay source volume on my phone.

The A/V receiver in my living room is a 2-zone system with a Zone 2 Preout. So there’s a 25’ RCA cable ($10 - do not waste money on fancy cables) going from the receiver to the amp.

The amp has two “main” inputs which go to all channels, and then each channel can also take its own dedicated RCA input — but I don’t currently use them. Since all the speakers are on the same floor, there’s no point in driving different sources to different speakers at this point.

If my Receiver had pre-outs for each channel of Zone 1 then in theory I could drive two of the living room ceiling speakers as rear/surrounds when watching movies by just wiring up the RCA jacks.

When I AirPlay from any phone in the house to the receiver it just defaults to playing on Zone-2. There’s an app which lets me change the zone that a source plays on, but I never use it.

In theory I could play a movie on the “house” speakers but then it wouldn’t be 7.1 surround; my receiver anyway can’t do 7.1 on the Zone 1 speakers while also doing a basic Stereo downmix over Zone 2. But I have never missed this.

Basically the use case for the ceiling speakers is listening to music during breakfast or dinner. The kids love choosing songs and having little dance parties morning and afternoon. Anyone can start whatever song they want from their phone. Of course sometimes that results in the children trying to override each other, but usually all in good fun.

IMO it’s definitely worth the ~$600 for dumb speakers, dumb amp, and dumb wiring to have absolutely future proof ceiling speakers throughout the house. The same exact system could easily be pumping tunes 30 years from now.

The AirPlay receiver that drives the amp doesn’t count toward the cost because it’s the same home theater receiver you’re going to buy anyway. It’s also the only piece of the puzzle that runs software and hardware (WiFi) that will become obsolete in a relatively short time frame. It does support CEC and it is also the source selector but honestly the only source right now is the AppleTV. All that is really kind of “besides the point” you could say when it comes to the house speakers. Anything could sit in front of it, as long as you can get an analog stereo output from it. It could be a Raspberry Pi even. The only requirement is being able to AirPlay/Chromecast to whatever is providing the RCA source.

It can be a huge mood boost and a great way to start the day before rushing the kids off to school to blast some tunes while cooking pancakes, and with eight 8” woofers the sound is a lot more immersive than a single “smart” speaker could muster.

[1] - Pyle 8-Channel Home Theater... https://www.amazon.com/dp/B002UL0XIQ
I recently bought a high powered microscope. My girlfriend joked about being able to watch our sex cells combine, but could not figure out any way to dispose of our new blastocyst that didn’t leave us both feeling very uncomfortable.

Now we have an answer!

This was not a serious conversation, but the ethical dilemma of such an interesting and relatively doable home science experiment was interesting to explore in theory.

Science is truly opening up more and more opportunities to make a real mess of ethics and societies guardrails.
Lucene is the best search technology, in my humble opinion, and is amazingly fast. MongoDB has it built in (full-text search, based on Lucene) and I'm using it in the project I'm working on.
Is it possible to slice the model up between multiple GPUs?
You don't need to pack that much food.

Collect all bodily waste and all unused food scraps. Compost it for plants, or feed it to creatures like tilapia. Nuclear power provides a source of light.
> at this point I would keep them regardless,

Gee, how magnanimous of you...
I play Starcraft 2 multiplayer a couple of times a week on a Mac and it's still great, just as it was almost a decade ago. It's not hard to make games work on a Mac. Linux, on the other hand, I've had very poor experiences with. It was my former default OS which I now run in a VM for development and I could never get games to operate properly without a heavy time investment.
I don't think buy-and-hold is unsophisticated or an incorrect approach. I hoped to mean that Tesla stock buyers may not be very analytical or make decisions based on stock fundamentals, but instead make investment decisions based on intangibles. Clearly anybody who took a position and held on is looking pretty smart right now, and a lot of market pros aren't.
If you have to run your code to understand it.

Try again.
This is not correct and in fact is the exact opposite. By default, they destroy the sample after analyzing it.
https://commons.wikimedia.org/wiki/File:Active_editors_on_En...
They launched Artifact in 2018, Underlords in 2019 all with first class, first day support for Linux.

Half-Life Alyx is coming in 2020.

The meme that Valve doesn't make games isn't real.
I'm not sure it's specific to a limited set of cultures. I think there would be fairly broad cultural support for it being considered diminutive. Besides, the core of the problem is that it's only valid when that business owner describes itself as a lifestyle business.
‘Contract Cheating’ Industry Has Gotten More Aggressive at Recruiting Students
Customer here... and, frankly, I hate it...

Now, not only is Microsoft weaponizing windows updates... they are weaponizing Office to push services without being asked?

I detest these dark patterns and decisions.

It's amazing how a company can make so many good decisions (IE: Open Source direction of .net) while also making such detestable decisions.
That would be even better. A static document with an URL. Then you "swipe" the URL from your phone/pad to the baking machine, which fetches the URL and reads the marked up recipe. You then confirm the ingredients on the baking machine, and it starts baking

I however want both "apps" and semantic "documents". Launching an app by typing an URL is powerful. And on Android you can now add an web app to the home screen.

We might not want the recipe to have the same capabilities as the "app". Maybe the apps should be closer to the OS, and "documents" opened in a reader app (browser).

One problem with the "semantic web" is that the added markup feel alien and too verbose. It was designed to be used with web page builder apps. But I and many others still prefer to code the HTML manually, with the help of a powerful editor (with autocomplete and macros). "Structured data" gets too hard to read by source.
An idea is to replace the many span and div elements with actual semantic elements.

In another post I ranted that nothing had really changed for "documents" on the web in the last 20 years. We are practically standing still, without any innovation. Probably due to browsers being overly complex and hard to develop. I think the time is ripe for a "document only" web browser, and we can start innovating again!
For example, the enterpise market is still using word documents, some use alternatives like Google docs. But web "documents" would be far more powerful. Instead of e-mailing files, you should just share a URL.

I'm currently working on an Editor for making web documents (but also for making web apps). I've put a lot of thoughts to how enterprise can use my editor to make web documents instead of word files and PDF's. Almost everyone are using the web today, but very few people actually make web "documents".
Calm down dude. It doesn't matter what people use to reference a third body.
That would explain a lot. Bianchi Green is very distinctive.
Justice Dept. Says Facts Did Not Justify Continued Wiretap of Trump Aide
If most gaming tables have mediocre GMs, then this could be wildly successful.

What's worrying to me is that most good GMs were at one point mediocre GMs. If they get replaced by a computer, we will end up with fewer good GMs.

I suppose this is the same complaint weavers had 100s of years ago about automated looms.
You nailed it. It can be either a neutral term or a slur depending on the context, as the above comment says. But I dislike it mostly for the reason you mentioned. It implies that the only really alpha, desirable businesses are those that make a bajillion dollars for VCs and don't have much benefit to customers or the general public.
It took me awhile to grok but I think that people like Schneier want to take the ideology of online anonymity and apply it IRL.
Both of you are correct. I meant I am salaried exempt and remote. Apparently I was also caffeine deficient at the time I wrote that...
Founder of Lunch Money (https://lunchmoney.app) here! I encourage you to check us out– we aim to be that personal finance app that was built for the modern-day spender.
I hope Valve will manage to bring official Proton support to MacOS one day.
Can you focus enough to read every word in a text for a whole minute? I can't, unless it is something extremely interesting.