skysight-inc/HackerNews huggingface dataset:
The phenomenon you described does exist[0], and similar effects (though rarely as severe) in cotranslational folding have been known for some time now. AFAIK it's not studied that intensely, as it's hard to study experimentally, and it is not expected to have a significant effect on final protein folding. During the folding process proteins often undergo partial misfolds, and defold again (the protein is basically doing a gradient descent search for the lowest energy state), so a small misfold at the beginning of the the translation process will rarely make it into the final fold.

Apart from protein folding there are other interfering folding mechanisms like chaperone proteins that also make it hard to phrase it as a straight "sequence -> structure" prediction problem, though they often only exist for a small number of the total proteins (in humans).

[0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737824/
I remember giving an "advice" on this in one of my comments: developers can discover amazing things once they step away from their day to day stuff,where there are already so many things created that it's pretty hard to come up with something unique. Gardening fits the bill pretty well in this case.
I have not, but like you am considering getting a PhD in this area.
Netflix snaps up rights to Studio Ghibli films outside North America, Japan
I don't do much screening. I'd just prefer to have him listen to Ernie Anderson playing Rochester than Amos and Andy.

Anderson was a black comedian getting top billing and a high salary. His character often gets the better of Jack Benny, and is always treated respectfully (as respectfully as any of the characters, anyway.)

Compare that to "Amos and Andy" where two white actors play blackface and are often the butt of the joke.

I know someday he'll be ready for Lenny Bruce and Richard Pryor, but frankly, I'm just trying to get a boy to bed... ;-D
The problem with gloves only would be the lack of tactile feedback to tell your fingers that the key press has registered.

I used a Datahand for several years and while it was very easy on fingers (the activation pressure was much less than typical keyboards, even Topre's), the tactile feedback from the switches was I think essential for typing efficiently.

I miss that thing...
I think the portrayal of the lawyer's lifestyle is a little exaggerated, but I agree with the larger point. Pay and work conditions are determined by social status as much as anything else and in the US, at least a lot of it (perhaps not the Bay Area), lawyer is a higher-status job than most.

I'm 35 and I can already feel this happening. There just isn't much of a career path if you don't go into management or own a business. Maybe at the huge companies (Apple, FB, etc), but not most, and definitely not in most geographies.

What I don't understand is why it's different in tech vs. other fields. Maybe because they're professionalized and can't be cut out? Whereas tech is more capitalistic overall and reinvents itself every 5-10 years in a way most other professions couldn't imagine? Not sure.

"Free pizza and snacks" does feel pretty infantilizing. Heading into my late 30s, I'm not game for that anymore. It's not even just the money, it's the overall approach to work, the open-plan offices, having little autonomy, little networking or visibility into the business, routinely having my judgment overruled by the latest VC-backed 22-year-old, dealing with stupid and avoidable tech debt, death marches, and cleaning up others' messes. After three failed startups, it's gotten tiresome to the point that I've decided not to work in those companies anymore, and really given a hard think to my personal career plans. Even as the executives of these bankrupt businesses have all failed upward into senior director roles at larger companies and sama and co. continue to preach the gospel of fast wealth and career growth at the latest darling run by "geniuses" 3 months out of YC.
TBH, the 280-character limit (and of course, the attention economy) doesn't really encourage deep and balanced discourse...
... I thought it was an automatic!
I've been wondering why people keep saying this. Do they not understand how password managers work??? LastPass and 1Password both work offline, the cloud is just for sync. Oy.
I would assume that a well constructed study would account for this.
Y2038: It's a Threat
Can we just get an npm package already?
In principle, you can use radix sort for pretty much any real-world data. All you need is a canonical binary "sort key" representation, and you can implement MSD radix sort on top of that. (For variable-length data like strings, the sort key can be a lazy iterator in case you need to break ties for initially equal sort keys, which of course requires MSD not LSD radix sort.) Composite data types can just concatenate the sort keys of their members, recursively, much like we build hash code implementations. At some point I want to release a sorting library which introduces a new Rust trait for this purpose.
> This is incorrect on multiple levels.

I'm very sorry but you are actually incorrect on every level.

>1. You don't need to perform mutations at all. You can have a recursive loop w/only immutable state. I suppose the compiler ends up mutating some memory due to TCE, but that's a principled transformation and not "cheating" or bad in any way compared to writing the code mutably up front.

Suppose? The GC must delete unused values or there will be a memory overflow. This is cheating behind a blackbox. The minute you start using those "immuteable values" the cheat is revealed via leaky abstraction.

>2. When you do use it, mutation is _always_ very explicit in Haskell and Idris. It is _more_ explicit than other languages! You can' tell if a Go function modifies its inputs or some global state without reading its definition. You can with Haskell :)

In haskell and Idris, you cannot do mutation period. So your statement is categorically wrong. When haskell or Idris "does mutation" it must feed it into an abstraction outside of the core language, aka cheating. This is what you mean by "very explicit"
Thanks for the sobering counterpoint to my perfect formula for success :)

A game is really a tough one though.
Dimes exist?

Still too granular IMO. If a penny is worth 1/31th of what it used to be, we should drop it and go to quarters.
Just a second, that's technically true, but the set of all "uncomputable but definable(?)" numbers is also countable, which includes Chaitin's constant (and any uncomputable number that can be reasonably called "X's constant").

Almost every real number is not only not computable, they aren't even definable.
A banana is a sandwich. Change my mind.
>What’s the deal recently with new accounts on HN peddling anti-western conspiracy theories?

That's a gross mischaracterization of what was posted.
Funny! Though the News Guidelines would prevent me from saying that.

A better reduction of the comment that loses less meaning might be: "This article is pointless, and intentionally obscuring that it's repeating universal knowledge. Why?"
The thing that disappoints me about the aspirations of being a researcher is that the goal is to get paid to study AI, not solve real-world problems.

I would rather build a small company by solving a real problem than work for a big company spinning my wheels.
By your logic, criminal sketches would be deemed inappropriate for criminal investigations as well. They’re both imperfect, but useful at the same time
Tap Strap 2 – Wearable Keyboard, Mouse and Air Gesture Controller
A Uniquely Japanese Take on Nostalgia
Doug Tygar, author of Why Johnny Can't Encrypt, has died
It was amazing to see the rapid progress on Excalidraw, all fueled by open source contributions but organized by Christopher. So cool to see what enthusiastic devs can hack together in short order
Mike, thanks for the feedback!

As a solo founder with a short amount of time before launch (and a day job), I had to decide to focus on only one thing for the main landing page. That ended up being selling the benefits of the product instead of focusing on the technical details. I recorded a 2 hour screencast going through the entire backend for devs who are interested in that — and I also plan to put together a blog post outlining all the tradeoffs I made. I'm sorry the documentation doesn't explain enough yet — I know it's lacking.

However, you're partly right: I think the people who would benefit the most from using Remake are probably designers and developers with 3-4 months of experience. Long term, I think they'll be at least 70% of Remake's market. However, I think it's also a great tool for more experienced developers like you.

It's true that you can make other stacks work for you, and, especially if you have a starter project you can clone, you can get something up and running within a few hours. However, Remake's true strength comes from the power of its mental model. The page state, page logic, and page structure are all nested together in HTML template files — which are the only files you need to create an entire web app, including saving data, enabling user accounts, advanced routing, and performing CRUD operations. That's a pretty powerful way to build something.

As someone with 8 years of experience building web apps, I can say with confidence that Remake speeds me up at least 500% when it comes to building simple CRUD apps. It's not good with building social networks or analytics platforms, but it's perfect for simple page builders. I'd recommend giving it a shot and seeing if it appeals to you before dismissing it. If nothing else, it might help you test out a few ideas you might dismiss otherwise simply because you can build them so fast!
SQL: Left JOIN and multiple matches on a key
There's also compilation that happens in Julia. Like the type inference. Which is to say, the time isn't just spent in LLVM.
> And any video you produce/enhance will not be able to be used as evidence by them.

It may not be good evidence in itself, but if the person is recognized, they could be investigated and more evidence found. It's not unlikely they'd be in possession stolen property, that their clothes match the video, that they left cell phone records in the vicinity and so on.
Protein structure prediction, at the current levels of precision (and I include AlphaFold here), is not useful for drug discovery.

It’s the sort of thing researchers say to get grants, but as a distant goal, not a practical reality.

For structure-based drug discovery (which isn’t even the majority of drug discovery), the details are what matter (e.g. “does this water molecule mediate a binding interaction, or do the sidechains shuffle a bit, and kick the water out?”), and these methods don’t even come close to predicting detailed interactions.

Metrics in this space are focused on “general correctness” of protein backbone conformation. Success is to achieve a kind of blurry view of the overall shape of the molecule, and drug design is trying to predict specific atomic interactions. They’re two wildly different problems.

About the best you can say is that if we had a generalizable model of physics that could predict protein structure, it might also be able to do a good job of evaluating how a small molecule binds to a protein target. But even that is a huge leap, and when you start using black-box methods like AlphaFold to specifically solve the problem of structure prediction, it’s not really clear that generalization is even possible.

There are potential practical uses in drug discovery for a method that can design a protein which takes a particular shape, but even that is pretty different from
what AlphaFold actually does.
They are working on it; please check for 'begin-concurrent' and 'wal2' branch names here https://www.sqlite.org/cgi/src/brlist
Thank you, I appreciate that! I'm gonna try to launch again anyways if they'll let me, simply because # of users and feedback matters more to me than revenue at the moment. That won't always be the case, but I'd like to iron out any major issues before feeling confident enough to charge for it.
A lot of the services have some legality questions surrounding them, so may be best to avoid suggesting any service. Much like bittorrent itself isn't a piracy tool, it's often used for piracy; in the same vein, IPTV is entirely legal, but may violate copyright in some implementations.
The progress of these are independent from each other.
Agree with your first statement and disagree with your second; I don’t think the former implies the latter.

I think there’s a lot of room to be clever with encoding domain-specific inductive biases into models/algorithms, such that they can perform fast+robust inference. Exploiting this trade off as a design parameter to be tuned, rather than sitting at one of the two extremes is potentially going to generate a lot of value. And this is highly under-appreciated currently since most people are obsessed with “data”. I’m willing to bet that this will become big in a few years when the current AI hype machine falters, and will serve as a huge competitive advantage.
>The best way to get ahead is to inherit wealth.

Not true in practice. 70% of wealthy families lose their wealth by the second generation and 90% by the third.

https://www.marketwatch.com/story/heres-why-90-of-rich-peopl...
Analyzing the Casper S-1
The trolley problem challenges people who don't consider choosing not to act equally an active choice or intuitively feel that action is different than inaction.

I would always pick the most valuable to me side and pull the switch or leave it be to bring about the better end result. Given the availability of self driving vehicles that reduce mortality choosing to drive oneself and kill more people is an unethical choice that will be as little comfort to the 3 victims as the one.
No, that's not why. You think there's considerable time spent in parsing? It's all code generation that takes time, which is the same thing that makes Julia powerful.
As a matter of public health, we should really be focusing the vast majority of our efforts on cancer and cardiovascular disease. Odds are that most people will end up dying of one or the other.
I wonder why you sound so snarky regarding this article.

It's not that the author defended them or said anything positive about them (except maybe "I've been there and can relate"). Nothing I read here surprised me, really. And it's not that he didn't mention that the burden was basically shouldered by the people there.
I can imagine that if some highly efficient cancer technique pops up, a vast amount of money would be freed to fund other fields.
Not totally. Those conditions have money and people working on them that could be put to work on cancer and heart disease.
Top Enterprise/Business VR/AR Conferences of 2020
> The strain has caused alarm because of its connection to severe acute respiratory syndrome (Sars), which killed nearly 650 people across mainland China and Hong Kong in 2002-03. Three people have so far died in the current outbreak, which has spread to Thailand, Japan and South Korea.

Coronavirus was also responsible for Middle East respiratory syndrome:

https://www.who.int/news-room/fact-sheets/detail/middle-east...

Coronavirus is also a member of the same group giving rise to the common cold:

https://en.wikipedia.org/wiki/Coronavirus
Yes, I have to admit I haven't read the actual study so this was purely speculation.
>Lisp based contenders ready for scientific computing

Any examples?
I'm leaning strongly on the side of thermometers were less accurate and gave a higher reading in the early 1800s.
It's the same list format from back in the WinAmp days afaik, but the reference points are video streams instead of audio.
Reserve Bank has been warned it may have to buy up coal mines
Early algorithm development thought about this quite a bit because system memory was really constrained.
Is Kotlin just a beta version of Java?
A Small Matter of Programming
Continuous integration with GitLabCI – Setup and integration guide
"Build something you would use" is going to be replaced by "build something a non-technical person has requested." The latter has a higher likelihood of not already existing and a proven appeal outside of the tech monoculture.
If you have Bitwarden in Firefox's toolbar the icon will also display a number indicating the number of available credentials, and clicking the icon to open it and then clicking any of the entries autofills.
I hated it at first but once I realised the use-cases I changed my mind. When you have regulations telling you to keep hold of documents for 5+ years, and you want to digitise them, then communicating through signed XML documents is a pretty nice solution. The format is suitable.

I mean, we're not talking about Twitter searches or any such useless stuff. It's inter-bank transactions, direct debits, payment pre-authorisation, etc. Everything that you really do need a paper-trail for for years and years.
Combining Drives Together with LVM (2019)
What’s special about kosher salt?
And half dollars exist as well, so we might not actually need to issue anything new.

Just slowly collect all the old coins, until only some collectors have it.

The quarter idea isn't as good because you are still doing math to 2 digits (for example sales tax would have to be calculated, then some kind of rounding). Switching to a single digit is simpler.
Man was I really hoping this was an API for cows in a field and sensor data attached to each beef. BaaS, or Bovine as a Service.
People usually choose quicksort because it is in-place and there are simple mitigations for inputs that exhibit poor performance.
Colour Trade Mark
Yep, which in turn contributes to this behavior unfortunately... The social media tools are setup perfectly for this - esp twitter.
> which is one of the hallmarks of cancer in general (most cancers at least)

It may well be the definition factor, at least some people think so: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/

If I remember their argument correctly, cells that "only" reproduce anarchically present little danger (benign tumor) if they don't also do so at an abnormally fast rate / metabolism.
The vast majority of people do follow that rule, but there are so many people reading these comments. If even 1% of them have a moment of weakness (or are kinda dickish personalities), they'll drown out the nice comments.
Schwab is zero commission now for stocks...Not sure what you’re looking at.
Contribute to open source projects you use... at least in the meantime.
Some more details at https://www.telegraph.co.uk/science/2020/01/20/immune-cell-k...

> The team says human trials on terminally ill patients could begin as early as November if the new treatment passes further laboratory safety testing.
Unless society is willing to allocate a larger percentage of GDP towards medical research it really is zero-sum which diseases get funding and which do not.
good luck man! do you still live in Boston? I used to live in Charlestown. It's definitely in my top 3 US cities.
Knowing that somebody is gay could also change how they might be received by an entire community, such as a church community that cares about child-rearing. A church might simply feel that a homosexual is not sexually safe around children, and it's not really an outsider's place to tell how people should run their own church.

But why should Peter Thiel absorb these blows for nothing? And his response? To fund somebody in a civil claim, because Gawker was depending on the fact that people are too weak to sue them. Gawker gambled wrong. The sad part isn't that Peter Thiel could choose which horse to back -- the sad part is that you need a financial backer to get justice.
I always use smalltalk when the problem would allow for it since I'm much more productive in smalltalk than anything else.
It's great for certain random tasks - i.e. Want to set up a websocket server for some reason? Program it in smalltalk, test it interactively (literally debugging on execution errors, fixing and resuming execution until it works).

If I'm writing a native windows app I'll go with dolphin smalltalk which imo is much nicer to work with and gives you a native gui. I have to say though pharo is getting better all the time and has an active community.
Oh yes,the famous brand products with less good stuff in them. Essentially,there are 3 unofficial markets in Europe: local market, western countries and the rest... Obviously the rest get it worse. European commission were investigating this couple of years ago,not sure where they are with it now.
http://www.europarl.europa.eu/RegData/etudes/STUD/2018/60884...
I'd consider a volume container for your database, the content is probably safe enough, since it's not a lot of heavy write. Then have a timed event that copies the DB out of the volume container for backups regularly.
Recruiters, a Necessary Evil in Tech?
Fair enough. Very specifically I think that book is pretty standard reading for anyone interested in epistemology of science - but that doesn't mean it is generally known.

I read the original as looking for books that are good in subject X, but not well known in that subject area.
> financial debt is very easy to measure and quantify but technical debt is not

For business school grad PMs I like to see if they can run with an analogy to selling unhedged call options rather than thinking of it in terms of debt with a known payoff schedule.

Even the bankers got derivatives wrong at an epic scale.
https://www.abebooks.com/first-edition/Politics-Qat-Role-Dru...
Religion, language, culture, where you lived, IQ/EQ, socioeconomic status, and temperament are more important than some of the 7 listed networks. The 7 listed "crossroad" networks were: family, high school, college, first job, marriage, where you live, and "Reassessments" (silly).

However I think there is a glint of gold somewhere in the dross of that article.
If China childishly invades Taiwan then the US would have to childishly declare war.

Isn't the whole point of the united states to be inclusive of all principles and values.

I think the whole rivalry from both sides is more because China is projected to surpass the US economically. The US wants to keep its dominance out of pride and China wants to dethrone it, also out of pride.

It's more of childish pride thing but at the same time both countries can potentially burn everything down if they act on the urge.
It's a little longer than 90 seconds, but you can find the full ~40 minute tutorial for that here: https://docs.remaketheweb.com/introducing-remake/

I agree, however, something short and sweet showing off the code and how to build something is sorely needed on the home page. I'll brainstorm about it and update the page soon.
Yeah this would ideally now be used if you want to make a trip to each city and stay for a day or so and not care about what time the flights leave.
This used to be my approach, but it prevented grepping through my password store (you have to touch the yubikey to decrypt each password separately)

I since switched to a separate on-device key for "low value" passwords and keep the interesting stuff (e-mail pwds) under the yubikey protected key (which does requires touch).

Did you find a better solution?
The Blue Ribbon SoundWorks (Amiga)
Some 2020 Predictions
I still use it but their support gets super defensive if you have any criticism about it. Their "new" 1pass X still sucks and recently has been going backwards in terms of usability. They keep promising feature parity between windows/mac too but this new browser plugin seems to be their fallback excuse. If I wasn't so heavily invested in it I'd switch in a heartbeat. I need something that works across ios/mac/windows and ideally without copying passwords to clipboard, that's pretty insecure.
>ie, the warriors are playing an infinite game that they enjoy. You can't win by out-arguing them. The only way to win is not to play.

Joshua: "A strange game. The only winning move is not to play"
IIRC we've at least made some progress towards slowing the progression of symptoms for some of them. Would be awesome to see some huge breakthroughs though.