skysight-inc/HackerNews huggingface dataset:
Not everyone is focused on solving folding. It's just one step of many. https://www.nature.com/articles/s41592-019-0666-6

https://github.com/yangkky/Machine-learning-for-proteins
It's also worth noting, that using a DB in a shared volume, even if you don't touch it outside the container, is MUCH slower... I was doing this for mssql containers and when I stopped, my spinup for a fresh instance went from nearly 90 seconds to about 15.
Observing what avenues for possible resolution exist seems like a good place to start and a productive line to pursue.

But it seems to me that there are some conflicts with deeper roots than IoB culture that have gone on much longer than the internet has existed: whether or not people should be able to be understood as property, whether sacred texts are meant to be understood in the same way as scientific descriptions when it comes to understanding cosmology, to what extent and where institutions like markets, or states, or churches should shape our lives.

Violence has been employed and even full-fledged war has emerged over questions like those, so apparently better avenues for resolution were unavailable.

Does that mean those things were also based in beef-first thinking? If so, was everyone on each side of those conflicts equally guilty of beef-first thinking, and that's how war happened?
I did dispute the charge. Then Uber wouldn't let me either use the app or close the account until I coughed up money.
Isn't the real elephant in the room obesity? And a culture around lifestyle and low-quality food that actively promotes it?

If you're sitting on your ass all day and then going out to drink a gallon of HFCS-infused coke (free refills) and a low-budget meal that could satisfy a starving family, of course you're gonna get to this point.

My personal thought with the US is "why does everything have to be so big?"
I am not the original commenter, but to be honest, you are casually dismissing very valuable points.

You claim that Whatsapp has E2EE, and that eleminates the need to trust them. Well let me ask you something: How do you know they have E2EE? You can't view the source code. Unless it's an open source program, the need to trust Facebook is still there.

And Facebook's history of continously violating user privacy can't be easily dismissed as well. If a company repeatedly collects data without consent, and sell them to third parties, you would be very naive to take them at their word.

Also the fact that Whatsapp was sold for $20 Billion is a huge red flag. Facebook isn't stupid, they wouldn't pay this much money without having a revenue plan.

So as TL;DR: It isn't 100% guaranteed that Whatsapp isn't spying on you, but we got to the point that until Facebook proves beyond doubt that they aren't, it's safe and logical to assume that they are.
"Postscript: there's lots more that I think would be interesting to say on this matter that won't fit in a tweet."

So... you send out another 20 tweets just like you did to make this story complete to get to the Postscript. Not sure why this story was okay to share in multiple tweets but his postscript wouldn't work in the same manner
There will be privacy until the singularity, don't worry.

Continued encroachments on privacy and personal autonomy may indeed deteriorate them, even cripple our ability to protect those rights, but simply worrying about that doesn't mean I must go gentle into that good night.
you could probably cover most of the todo example in 90 seconds
Both the teams and enterprise options also allow you to share any credentials within an organization/team, though the default for any new credential is no sharing. I assume that's exactly how the family plan works as well?
I think this happens to everyone.
No one instinctively knows how to do this.
In addition, you learn by seeing existing designs and critiquing them (positively or negatively... knowing what to avoid is almost more important IMHO).

I would even say that most people working in software can only fill in the blanks, they absolutely cannot start from scratch (which is in truth very hard).
Great post! How many projects have you done before actually getting paid for your SAAS?
So who has the mutation in their T cells already?
exit to the tarmac
Technology Needs to Reconsider the Bathroom
> A back-up tool should open files to backup in a mode that disallows others from writing to it, and retry that a few times, each time after waiting a few seconds.

Generally the preferred approach for backup programs is to trigger a file system snapshot - after quiescing the disks - and back that up. Sometimes (eg databases), the backup program is able to run application specific logic that works in with this (eg flush all database buffers before the snapshot).

For the filesystems that don't offer snapshots, some still have the ability to freeze the file system to allow a consistent backup.
Productive Romance
I'd like feedback on this mentality for using romantic desires to achieve non-romantic, higher level goals.

https://write.as/risky/productive-romance

Thank you
I believe Rubinius _is_ being maintained (again), it's just going in a direction very different from Ruby.
Economists have been debating the skills vs signaling value of education, especially since Bryan Caplan released his book The Case Against Education. If you want to get a smattering of opinion on the issue the book's reviews and dicussionsn would be a good starting point.

https://en.wikipedia.org/wiki/The_Case_Against_Education#Rev...

Bryan Caplan back and forth with Noah Smith on the book: https://www.econlib.org/archives/2015/04/educational_sig_1.h...

Bryan Caplan back and forth with Bill Dickens on the book: https://www.econlib.org/archives/2010/08/education_and_s.htm...
Scientists Discovered ‘Mini-Computers’ in Human Neurons
What criticisms?
I made my first open source contribution on this project and watched how it evolved day by day. Absolutely love it!

Here is the repo: https://github.com/excalidraw/excalidraw
It's strange to see someone argue how "Twitter doesn't matter" when it's been a main platform for the world's most powerful man. I use Twitter but don't follow Pres. Trump or find it useful to engage with his tweets, but it's undeniable that he's used it to material effect. [0]

In any case, Twitter is also a very useful platform for the disenfranchised, including those who complain about corporate practices. You come up with a stilted example of "I demand anyone I disagree with be exiled to Elba" and declare that Twitter doesn't already matter, but you're ignoring the many daily situations when companies and organizations actually do respond to tweets, and make explanation or change behavior?

[0]http://www.abajournal.com/news/article/government_says_trump...
They only have a problem with rust because of the C.

(excuse me, I'll see myself out. Couldn't help it, my initial reaction was "how can Rust possibly create problems for the navy???")
If you haven't tried property-based/generative testing, I urge you to do so. You'll never want to write unit tests again (this is an exaggeration of course, but not much). IMHO the modern cult of unit testing has about the lowest effort/reward ratio I've seen among standard programming practices. Put that effort into isolating non-trivial invariants in your code (which might actually require thinking about the problem, i.e., producing an informal spec), asserting those invariants everywhere you can in your code, and writing generative tests that just test your assertions with random input. Then you can think of higher-level invariants ("properties") that might not be possible to verify in the code itself, and write property-based tests to verify those invariants. The most important such invariant is that your program computes the right answer. You can test this by creating a "model" or oracle which you are confident will compute the right answer (albeit perhaps horribly inefficiently), and writing property-based tests that verify that the model gives the same answers as your code on random inputs. ("Inputs" in this case aren't just user data, but also sequences of operations or state transitions; they can be any data that your code bases its decisions on.)

Unit tests will always have their place as 1) a minimal, provisional test suite for initial development, and 2) some finite set of important edge cases that might not be covered by randomly generated test cases. But they are much less efficient (IME) than generative testing in terms of developer effort per-bug-found. Additionally, property-based tests force you to think systematically about your code to identify important invariants, and that's always a good thing. You can spend the time left over from not writing useless unit tests in writing functional and integration-level tests, which (IME) are far more likely than unit tests to yield bugs (which IME generally reside in unanticipated interactions between components rather than internal logic errors).
It's not a majority view among economists. Caplan is the only person I can think of who holds this view.
My wife is allergic to peanuts, lentils, chick peas, etc, but not almonds and the like.
> The findings, published in Nature Immunology, have not been tested in patients, but the researchers say they have "enormous potential".

then later:

> However, the research has been tested only in animals and on cells in the laboratory, and more safety checks would be needed before human trials could start.

The abstract for the original article notes:

> ... An MR1-restricted T cell clone mediated in vivo regression of leukemia and conferred enhanced survival of NSG mice. TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma. ...

https://www.nature.com/articles/s41590-019-0578-8

What does that second sentence mean?
Can you give some examples of simple open cross platform systems that make money?

I like my apps to be apps and a lot of the "Apps" that are HTML/js are janky cross platform and are tricky to pay for (vs one touch on ioS)
for a lot of people who end up in research-type jobs, a sense of curiosity is one of their strongest motivators, and they want work that will let them pursue their curiosity. it sounds like you're motivated by something else.
It may or may not work, but try applying the below project to a few frames to see what you get. Make sure to preserve the original footage on the original media, though.

https://github.com/alexjc/neural-enhance
It seems correct to me. If I get a degree from MIT, somebody else can't. They have limited spots. He is promoting models of education for signaling employers that are not zero sum.
Resemble.ai, AI Generated Voices
That's the bottom end of the RTX cards. $300 for a low end card that would have been $150 a few years ago.
Not that it matters much, but femtolisp is not a new project. The bulk of the code has been around for at least a decade.
Heliocentrism vs. Geocentrism
All this mass-parallel processing for the energy intake of a 100 watt bulb.

Not too shabby.
Follower Clusters – 3 Major Use Cases for MongoDB, MySQL and PostgreSQL
Europe is truly unique in this regard. For instance, my father in law bought a Lithuanian made furnice from a retailer in Latvia because it was cheaper than if he would have bought in Lithuania. Car reimport exist as well,where a German would buy a car made in Germany from a Lithuanian dealer and transport it back to Germany,because it's cheaper. There are some companies that import medication, repackage and sell abroad in markets where the same medication costs more( this one is an old one,not sure if it's still the case)
The situation is not written entirely with static types if the run-time processing requires the expression of dynamic typing. That's based on some actual dynamic typing from the language, or else some ad hoc dynamic types cobbed together in the program itself.
Agree. Out of context, this takes a ton of effort to understand.

Some examples

- Great Weirding morphs into the Permaweird

- underground Internet that I’ve previously called the CozyWeb

- unflattened Hobbesian honor-society conflict

- Mookcoins are mined by knights through acts of senpai-notice-me

- retreat into what I call waldenponding or to the CozyWeb

Several of these link to other essays which, in turn, use ever more jargon whose definitions are found in yet other source material.
3d artist here, yes Renderer can use your GPU RAM while rendering.
"Hobbyist" doesn't really make sense, as it's not my hobby to make MP3 playlists.

"Amateur" is good as an antonym to "Pro".
> Bay area tech beaucoup bucks in flyover country is a recipe for early retirement.

Does anyone get paid bay area rates in other areas? I have never heard of this. I work remotely for a bay area company and get paid based on local rates.
Because you cannot do a controlled experiment, it is probably impossible to control for all the variables that are all confounding each other... education level, IQ, talent for delayed gratification, etc. Wealth impacts all of those, but is also caused by them.
Survivorship bias or reality:

3 months learning FastAI, 3-12 months personal projects and consulting, 2 months flashcards of ~100 papers, 6 months to publish a paper

What does he mean by ‘paper’? A Medium post? NeurIPS?
I think an implied part of the question is how did the british do it despite having customs and building habits designed for a colder climate. E.g. british troops had stuff uniforms, and british building styles weren’t designed for india.

Hence was much of the answer focusses on “going native” with “mughal dress”, local building styles, etc.

So, how did they adapt the face of apparent resistance to abandoning all of their normal customs kept up elsewhere.
"But then, why does Lopez mean "wolf" and not "son of the wolf"? And shouldn't "Martinez" be "Son of Martin"? "

According to Wikipedia:

"López is a surname of Spanish origin. It was originally a patronymic, meaning 'Son of Lope', Lope itself being a Spanish given name deriving from Latin lupus, meaning 'wolf'."

"It originated as a patronymic surname, meaning 'son of Martín'... itself derived from the Latin Martinus, whose root is Mars, the name of the Roman god of fertility and war."

.

So it seems the article left out some detail from each.
Risk in developing a simple SaaS solution
Has anyone developed a simple SaaS solution and had it cloned before gaining market traction?

The app that I developed is extremely simple and took about 5-7 hours of development time. It solves a very specific problem for B2B companies.

My worry is that, since its highly simple right now in its MVP form, I feel like either the customers will defer to "I can build it in house" or worse, an incumbent could easily add it as a feature to an existing app. I also remember the famous dropbox comment, where a user mentioned that they could easily replicate the product with rsync.

Do you just press on and begin finding product-market fit or would you add some more features to deter copycats at this stage?
At least for Alzheimer's there has been some hopeful advances recently[0]. Given the state of the low research funding allocated for it (especially compared to the disease's prevalence), that's pretty good progress I would say (and hopefully enough to spur more investment into solving it).

[0]: https://www.alzforum.org/news/research-news/2019-year-hope-a...
Not really a great article because it mostly perpetuates the confusion rather than clears it up.

Context determines whether a strawberry is a berry or not. In common usage it is. Using a scientific horticultural definition it is not. Context usually determines which definition of berry applies implicitly, though if you're communicating in a context where you think it's reasonably ambiguous, you can be explicitly about which definition you're using.
Consider if your trading algorithm simply searched the history for that sliding window of data and then presented the following data as it's "prediction" -- it's utterly useless. This is the function of a compressor rather than a predictor.
China to ban single-use plastic bags and straws
Not sure if this was already posted here, but the source code of No One Lives Forever is available:

https://github.com/osgcc/no-one-lives-forever
Or our entire evolutionary history of data.
this describes a t cell receptor that recognized and killed cells from several cancers while sparing healthy cells

theoretically this could may made into a therapy by taking t cells from patients, modifying their DNA to express this receptor, and then readministering the modified t cells to patients

there are two FDA approved drugs that use this basic approach. however, this only works currently in "liquid tumors", not "solid tumors" like breast cancer, lung cancer, prostate, etc

This article gives a nice, simple explanation as to why solid tumors are more difficult (scroll down to the chart): https://www.the-scientist.com/features/the-next-frontier-of-...

if this works, then the first challenge listed in the chart would be mitigated. however the challenges of a suppressive tumor environment and sufficient delivery to tumor cells is still a major unsolved challenge
That video isn't the Dirty Jobs video but it does show the same room and process (just without all of the Dirty Jobs humorous commentary)
Do you know if there are any nice UI implementations of this around? I'm interested in building on your work to make a more fully featured site!
Not bot, not beast: scientists create first ever living, programmable organism
This also makes it easier to process it in Excel afterward.
A dead comment mentions even rank and file troops had servants. In previous centuries it was much more common for middle status people to have hired help.
Same thing in our new building. They lower it for a few moments, then full blast. I wear blue blockers for more than just my screen these days.

The other issue - my boss has his own lamps in his office and keeps the room light off. But it goes on every time someone walks by his office - though it's not triggered inside the office.
Interesting. Seems to be the first modern non trivial compiler that avoids using SSA internally. I thought SSA had cornered the market, but perhaps now there is an opposite trend (ok one example doesn't make a trend)

<quote>
No SSA (single static assignment form) for:

Faster optimizations for short optimizations pipeline and small functions (a target usage scenario)
Currently SSA could be used only for two optimizations (CCP and GCSE). SSA usage would mean 4 additional passes over IR. If we implement more optimizations, SSA transition is possible when additional time for expensive in/out SSA passes will be less than additional time for non-SSA optimization implementation
Simpler and more compact generator code because we can avoid to implement a lot of nontrivial code (for dominator and dominator frontier calculation, a good out of SSA code)
</quote>
It's almost like our social bonds are being broken in the same way chemical bonds get broken when we digest food. Like our capitalist society is a higher-order organism that is extracting energy from our societal bonds.
Hmmm, so I took this source code, compiled and it is still 100%.

I mean - the strat was published 8th of November, and you could say it was overfitted. But it continues to run. Since 8th of November it closed only 1 trade, but also $500+ profit. (second is still going, but currently profitable).
Two standout points from this essay:

1. I've long heard that various SaaS companies really didn't like the Affero General Public License. Kuhn makes a case for why this is a validly justified concern, something I'd not previously considered.

2. The copyleft restriction termination is a really interesting concept, though not without its own set of consequences which should be closely examined. Historically, the advantage of copyleft has been that it applies equally to all. The abuse of it (by firms also marketing properietary solutions) is a problem, but removing copyleft obligations entirely might not go as intended.

3. Copyright assignments to copylefted codebases without an explicit restriction of those to require copyleft-only usage, a distinction which differentiates strongly between the uses at, say, FSF vs. MySQL AG / Oracle, clearly also present issues, as has long been argued.
I've beaten tetris. Twice!
I asked you about content strategy vs tactics in another comment and you responded with “tomato tomat-o”. Not the most engaging of replies. It’s apparent this was click bait to begin with.
Yes, the lastpass exporter has an issue. You can do a search and replace.

Or you can do what I did and when I reach a site that had an issue, I would just look at the password and there would be an obvious parsing error, e.g "&" is instead "amp&" and would just modify it manually.

Only happened a few times and then all is good.

https://github.com/bitwarden/help/blob/master/_articles/impo...
What if we are machines?
Why I didn't go into academia but GL convincing other people of the value in that. I am sure there are cultural differences here but where I am, the goal of most people who study CS is: leave me alone while I mess about with X (evidence: the local college was doing speech processing/nlp in the 60s, they actively turned down paid work...unsurprisingly, they got left in the dust, professors are now being encouraged into doing commercial work but, of course, most of it is totally nonviable and is just more messing about with complex nonsense that doesn't work).

I think if you look at history this is also evident: the inventions of the late 18th century were a function of necessity, the invention of semis (not just in the US but how Taiwan developed)...this isn't to say academia is pointless but there is just far more going on (I think if you look at some of the East Asian nations that get great academic results, their progress on actual R&D innovation is far less impressive).
I think the problem with the intrinsics approach is that lots of this code isn't stdlib but extensions like: https://github.com/ged/ruby-pg/blob/6853309b64852755daed3e9c...

I don't really see a good solution here other than lifting the control flow to Ruby with specific bytecode ops to minimize overhead and a good, typed FFI like LuaJIT has? Am I missing something?
Yes, there are quite a few Ruby implementations but MIR is not one nor is it trying to be. It's a standalone library useful for use in a tier 1 JIT for any dynamic language, along with other uses outside of JITs having to do with native code generation. The author does have plans to integrate it into CRuby to work alongside MJIT.
It is, but it’s very easy to use and comes preinstalled.

Besides, a softsynth won’t sound good without a bit of reverb, and if you want to play, at some point you’ll want to record it.
She can only sell it for the purchase price adjusted for changes in the median income. If the median income in the city goes up (which it does over time because lower income renters are eventually forced out of the city), then she can sell it for more. It obviously won't increase as fast as market rates, but it will go for more than she purchased it. The house needs to be sold back through the BMR program. It can only be willed if her heir(s) also qualify for the BMR program at the time of death.

At the end of the day, she gets the benefit of not having to tie up cash in home equity. While other people are paying $6000 or more a month in a lease, she's paying a little over $2000 a month in a lease and gets to put all the excess she has into more liquid assets like an index fund.