skysight-inc/HackerNews huggingface dataset:
"Nobody is saying acetaminophen is ineffective"

Actually, the linked article is saying exactly that:

"I remember being annoyed that in order to get narcotic pain relief I was being forced to take a hepatotoxin that added little to the pain relieving efficacy of the opiate."
I'm a fan of this book, but not of Nathan Myhrvold's business practices. Conflict!

More importantly, I have neither the funds nor the space for such a magnificent work. Myhrvold + Company: please disregard my above comments about Intellectual Ventures, and if you're reading this, please know that I would be honored to review your work...
I like being able to see function signatures in a header file.

In Python or Matlab, I have to read the implementation to see what types it wants. To me, having collections of type signatures in a separate file is a huge boon when I have to come back to code I haven't seen for a while - it's a 10,000 foot view of what the code does that helps jog my memory - and it's guaranteed to be accurate, unlike documentation.

To the extent that static typing supposedly prevents bugs, I agree that it is overrated. My neutron transport solver I wrote in Haskell had plenty of god damn bugs after I got it to compile, thank you very much (perhaps a very deep Haskell-fu is required to attain the mythical "neutron transport solver that works right the first time" - in any case I realized that compiler-aided bug prevention is not a low-hanging fruit in Haskell, so I lost interest).

That was a long-winded way to say that I feel lost and alone without function signatures, and that this preference is possibly only quasi-rational.
Show HN: A JavaScript memoizing function decorator.
I think you meant to write: "the future is freemium." This article doesn't mention micropayments.

I'll be damned if those aren't some good ideas regarding accessibility though. I don't know if the marginal value with those kind of features is worth it, but it sure seems like a better alternative than fruity redesigns like the new Gawker shit.
And the poster here just plagarised my original tweet:

http://twitter.com/#!/schwa/status/36618789894361088

Lame.
That is absolutely false. NSAID related morbidity and mortality does not include APAP, as it is in an entirely different class of drugs. I'd be interested in knowing what sort of training you have in pharmacology, as everything you have said throughout this thread displays a level of ignorance that I did not think existed on this site.
Ah I see. Since 6/20 cities on the list are in the Central Valley, the far-away, far more populous Bay Area[1], LA, and San Diego must also be miserable.

[1] Yes, Vallejo is technically in the Bay Area, but it is so far away from SF/Oak/SJ, that it hardly counts.
I think this is a problem social media is going to have to solve. Much of the privacy/data mining/etc issues stem from the fact that advertisers are the customers, not the users. And with the absurd valuations, there's going to be an insane pressure to monetize which is going to lead to some really dodgy business decisions. So there has to be another way.

Reddit's gold subscriptions are $3.99 a month. Maybe this is too much? What if Facebook started charging $1 a month to remove ads? What about $0.50? Would people pay it? At that point, it's really not the cost that's an issue, it's the hassle of signing up.

I do really like the idea of an aggregator service where the providers receive a cut of the subscription. But is an API (say, restful JSON) so much less bandwidth-intensive on a large scale that this is more viable?
I went to Brooklyn Tech, like Stuyvesant it's one of the Specialized Science High Schools (at the time I went there were only 3, Stuy, Tech, and Bronx Science) with entrance via examination. I can tell you that my high school experience was completely different from the average NY high school experience. When everyone in your school is there because they're motivated and intelligent you have a much easier job of teaching. Furthermore, if the students do misbehave in any major way you can kick them out and send them to a non-gifted school. Regular schools don't have the same luxury.
Yea, Techrights has several cases where ex-Microsoft people that was hired recently led the company to add a MS stack as an option. It is interesting that an issue that was discussed there years ago has become more widely discussed recently.
This is true, all our warnings might only encourage people. Perhaps the best thing would be just to leave it unmarked, let the curious spelunkers die of radiation poisoning and that'll probably serve to keep more people out than building monoliths... or especially buried monoliths.

I mean burrying monoliths may only serve to get people to dig deep and reduce the natural shield we wanted to protect people from the radiological materials.

Burying them in a place where no one will go, meaning they'll have to have a more concerted effort to dig in say the middle of a salt flat. Meaning some level of organization and technology to dig 1,000ft deep in the middle of a dry salt water lake bed a hundred miles from drinkable water.
I find some interesting API from Mashape.

This is my favorite: http://www.mashape.com/component/BarCodeGenerator
I just wrote this simple decorate function that I'm looking forward to using in my programs. It worked out quite nicely in this fibonacci example.
Simplegeo
The public domain shouldn't matter. Publication could.
I'll stick with my standalone (non-MS dev) VM images, thank you very much.
The drop-downs seem kind of laggy. How do you position yourself in relation to GWT?
>I believe that the people who avoid that temptation and create undiluted games with procedurally generated content will be the ones whose games are played for decades to come.

That'd be wonderful. The "empty" feeling of dilution, and the absence of real content, are issues our team are tackling head-on, with full awareness of such pitfalls. As an example, I was raised on the early Final Fantasy games. A huge, huge part of their appeal was the music — beautiful themes with expert execution by a masterful composer (Nobuo Uematsu). Even now, 20 years later, I have friends who grew up playing the same games who still remember the music. We can hum the themes to one-another, and reminisce about our youth beguiling away many an afternoon absorbed in the stories of these virtual worlds.

But if the stories were procedurally generated, or the music, or any other "hook" that will be remembered by the player, the shared experience is suddenly lost. People may play the same "title", but they haven't played the same game. This is a big, big challenge — how do you leverage the power of dynamically generated content, without breaking the consistency of experience within your game and the commonality of experience between players. How do you create shared memories?

It's easy enough to take a game like Diablo, where the maps are random, or Boarderlands, where the weapons are random, and discuss the game with someone else, arriving at a shared impression and similar memories of play. But if the maps, weapons, quests, characters, sounds, music, rendering style, dialogue, plot, gameplay rules, setting, and even game genre are in some way "generated"... how can you still have a shared experience?

Whoever comes out with a solution to that will be doing some fascinating work.

Also, from what I've heard, the next Elder Scrolls (Morrowind, Oblivion) game is going to have some aspect of procedurally determined quests. I'm excited to see how they do that, as it's not so often that a big studio like Bethesda takes on such an unproven concept.
He used 23andme. And they only give you data for around a million SNPs (http://en.wikipedia.org/wiki/Single-nucleotide_polymorphism).

The cost of sequencing decreases by a factor of 10 (!) a year per base pair. I will wait until it's cheap to sequence my whole genome, before I'll shell out the money.

(Synthesizing also gets cheaper by around the same factor. But it started from a higher level of cost.)
I've been seeing recommendations to run them under compatibility mode if problems crop up; try that, and if it doesn't work I can boot 7 and give a couple things a try myself.
Rookie comedian describes his gut-wrenching first performance (podcast + video)
Lennart Poettering - Creator of Avahi,pulseaudio, systemd http://0pointer.de/lennart/
> Also, the mutant sickly plants will be a good indicator.

The plants won't necessarily be sickly in 10,000 years. Tobacco shows substantial resistance to radioactivity, especially considering virtually all tobacco contains Po-210. It also survives with isotopes of Plutonium, Polonium 209 and Americanium... amongst many other radioactive elements it can pick up and thrive despite.
You're making a huge assumption that all machines are patched.
Could you ask him what is the single most important thing that makes Watson possible, whereas Watson would not be possible five years ago? Was there an advancement in querying unstructured data? Or was it simply disks got big enough to hold a lot of data?
I can't speak about the site or the quality of the instructors but i have nothing but appreciation for Charles Max Wood, the instructor for the Ruby and Rails course. I think he also conducts the ruby programming language course.
Check out his free online videos on rails at www.teachmetocode.com. They are free and will probably give you a good idea about the pace at which he conducts his online classes.
As a former ITA employee, I was amazed by how great the ITA inventions agreement was in this respect. It has set the bar for negotiations in my future employment negotiations.
You need a high level of traffic before you can really start drawing any statistically meaningful conclusions from A/B testing. People don't magically start showing up just because you publish a landing page, so some assumptions are necessary for the first version.

Sites like http://fivesecondtest.com/ or http://www.usertesting.com/ are a lot more useful than A/B testing when you're about to launch your first landing.
I hear that you can turn words into freakin' links with the proper code.
Great idea, go for it!
I always felt that the "sun tax" was an appropriate way to describe living in california.

If you could pay for sunny skies 330 days a year (like in LA), how much would that be worth to you?

That's why the cost of living is higher in California. Simple supply and demand.
We don't have the technology to build a video player that'll last 10,000 years, nor a power source that will last that long either. Leaving data media is fine, but anyone with the technology to play such media will probably understand the danger quite quickly if explained to them in words.
No, I don't really care. I am a supporter of copyfree, but I can't make my wiki public domain, not without asking people to relicense their contribution.
<insert derogatory anti-religious comment>
Well the original is the blog entry, this is the actual pull request. Plus, this title is a lot funnier. What do you expect late on a Saturday night?
Where's the production guide? In any case I did go and look at the book's webpage and your right. The images are stunning. The Kindle would not do this book justice.

I can't justify paying that price for the book, but it is really tempting.
Absolutely! - my username @ gmail
What makes you think understanding of radiation is necessary to dig?

Even if they had that understanding, why would they bother using a geiger counter on an archaeological dig?

And plants can adapt - chernobyl is quite hazardous, but plant life still grows there, and there's no guarentee that any effects on their growth will be understood (and any level of radiation enough to _really_ effect them will effect people standing on the surface too)
There's nothing more fun than stomping on an existing object hierarchy.
Us JS programmers do like our monkey-patching. I suppose I could have done this with a stand-alone function ... but the syntax would not be 1/2 as "cool".
Malcolm Gladwell wrote a similar article in the New Yorker:

http://www.gladwell.com/2010/2010_01_18_a_surething.html
Charles teaches Rails; Peter Cooper teaches the Ruby language.

I'm a founder of CodeLesson and also an instructor. Happy to answer questions here or privately at my username at gmail.
Run it in a Virtual Universe with the ethernet cable unplugged.
The US Embassy compound is on the Akasaka side of Roppongi and the Embassy itself is towards Toranomon. There is also a small US Army base between Roppongi and the Aoyama graveyard, right next to the new National Museum.

FWIW, it's not just the Japanese that can not get into that base, civilian US citizens will also probably find trouble getting in. Which is a bummer since the PX there sells affordable cuts of meat.
I miss this site. I remember checking it daily. Too bad they stopped updating it.
They actually did exactly that. They didn't do a hard de-list for JCPenny as in the bmw.de case, only a tweak to the link weighting to remove the type of bogus link JCPenny was benefiting from. So they've dropped down 30-50+ positions in a lot of cases, as have other who were benefiting from similar links, but they are still being fairly listed.
What was interesting for me is that CSS was developing around the same time. The first draft was released right around the time of Netscape 0.9.
No, of course there isn't any value. But ibuprofen isn't as harmful as acetaminophen.
If I break into your office, steal your secret source code, and give a copy to my brother, what part of "existing theft and trespassing laws" prevent him from selling that copy to the highest bidder?
did I really just say "there's president"? jesus.
Ways to monetize the Web with PayPal Micropayments
Not everyone here is a longbeard.
This looks awesome. This may seem shallow, though, but when I got to the setup page, I was a little disappointed with the complexity of the setup required.

- Why are you using MySQL instead of SQLite or something even simpler? Surely my personal music streamer doesn't need serious scalability.

- Why does the setup require futzing with my Apache configs to use mod_rewrite? For just streaming music, I'm willing to put up with ugly ("something.php/directory") URLs. This would also make it easier to get up and running with non-Apache web servers (lighttpd, for instance).

- Do I really need to use a non-default PHP configuration? And increasing the interpreter's memory limit seems a little ominous.

This is all to say that perhaps the right way to deploy something like this would be as a single program you can run that has its own built-in Web server. As it is, the configuration is daunting for a home computer (although completely reasonable for a real server setting).
Because of your reminder, I'm listening to the FF6 opera right now in my mind, even though I haven't heard it for years. (Celes: "Oh my hero, so far away now, will I ever see your smile? Like night into day, you're so far away, it's just a fading dream."), so I understand what you mean very well about shared experiences and the like.

It sounds like you understand the weak points of procedural generation quite well, so I think you'll be able to use it to full effect and create a great game. Good luck! :)
I don't understand what part of my argument you're disputing. I never said that the federal government doesn't have the constitutional authority to legislate intellectual property protection. I also never said or hinted that IP law is "special-purpose legislation."
He's saying that "thinking of famous startups you yourself know" is a form of bias. He's just too nice to say it.

Who cares, by the way, whether a startup is going to "scale" past a 10-person shop? A 10-person shop started by an immigrant creates 9 jobs. That's past the threshold in the existing bill you're championing.
Seems a bit silly to call a RAZR a computer

Um... any definition of 'computer' that excludes a RAZR is just plain wrong.
The fifth sentence of the first paragraph of the linked article is "Thanks to RFID tags embedded inside them, the chips with denominations of $100 to $25,000 could be immediately deactivated rendering them unredeemable for cash value."
Applying the model of creating Hollywood movies to software?
He mentions denatured alcohol which has been around for a century and includes chemicals to make it toxic or foul tasting.

He doesn't mention that during prohibition, the government attempted to discourage the redistilling of industrial alcohol by adding poison or upping the concentration of toxic denaturing chemicals, killing thousands of Americans.

http://www.slate.com/id/2245188/

Edit: I'm not sure what the entire story is. It seems as though 10% methanol is standard for denatured alcohol. Not sure if that was the case before prohibition.
I could probably work it out in a few minutes on the back of an envelope. You just have to know the radius of earth (around 6000 km), the strength of gravity at surface level, that gravity of a sphere is the same as that of a point mass, and that gravity drops off as the inverse square of distance. Add in some integration, and a guess about how big an orbit is (just choose infinite size for an upper bound, if you aren't sure), and you are set to go.
Wow, that's weird. It's like they're multiplying...

http://www.megaupload.com/?d=S1B3JZL9
Was working on a server and

418 I'm a teapot

...seemed worth investigating. http://en.wikipedia.org/wiki/Http_status_codes
Ask HN: Accepted into a pitch event - but were not sure we want to raise money
I originally applied because I love what my company is doing and I want to tell anyone who will listen and also to create relationships with investors so in the future, if we did decide to raise money we'd already have a rapport.

I asked for help with the exec summary from a friend who has raised ~$500,000 and he told me investors would never give us money for the reasons I had outlined. He suggested a slight pivot then created a whole back story for the pivot and while its somewhat compelling, it creates a entirely new set of problems and I'm not as passionate about the pivot as I am about how were progressing now.

I am positive there is a need for what were doing in its current form and while we could definitely do it without raising money it would be helpful to hire a few part time people to fill in the gaps of the skills my cofounder and I lack. As opposed to finding someone who a) has the skills/drive required b) we click with c) in a financial position to work for equity.

So I guess my question is, should I:

1)Pitch the the company as it is now, and when asked what/why we need the money for come off as inexperienced.

2)Pitch the pivot version that I am less passionate, creates a whole new set of problems I haven't properly thought out and in a direction that more then likely we will not go.
I used Yammer at our last startup and at our current startup. While I think there are some concerns with what you potentially may say or don't say on a Yammer feed, the benefits for us far outweigh the disbenefits.

Not to mention most of the stuff people post are pretty vague and would only make sense for those involved. It's a good and valuable tool if the culture and habits are developed correctly in adopting Yammer early on in any company.
Ask HN: Best way to send out large-scale emailers?
A friend of mine has been running a fairly successful e-commerce operation for the last 3 years, and he's been having trouble with sending emails to a mailing list of between 700 and 800k email addresses. Basically, the volume of emails is starting to bog down his servers and T1 lines. Does anyone have suggestions for 1) balancing he load when sending the emailers out to minimize the impedance of email campaigns on the servers and connection or 2) a cost-effective alternative to which the email campaigns can be outsourced.

Thanks!
I think that rather than just throwing out numbers, what they should do is evaluate what the actual cost of education would be and remove all the useless excess courses added to the curriculum unnecessarily.

Blindly raising tuition and charging more than necessary isn't good nor is it smart to just slap a blind number like $10,000 and ignore all the economics at play. While I think the four year rule is somewhat good for commitment, I also strongly believe the education system needs a major makeover instead. Not all degrees are the same and should not all fall under the same timeline as each other. Everything should be restructured to make the best of each person's education instead.
"Eyelids now close in proper way. Fixes issue #42." I find humor in this.
Citing Wikipedia for medical information on pot makes clear what kind of research process is necessary to conclude that pot is beneficial, which is not the conclusion of most people who have done the most careful research. (I'm a wikipedian, and I'm painfully aware of the research standards on the free encyclopedia that anyone can edit.)
If this is misery I'll gladly continue to suffer.
No, you won't. Try moving the steering wheel in a parked car.
1. You can use SQLite or postgres if you'd like :) they all work in my tests. Just replace the database connection string with the sqllite or postgres one. My docs are just for a common lamp configuration. MySQL is a bit more performant thanks to the query caching part.

2. the mod rewrite is part of the framework I'm using (Symfony 1.4). just makes things a little easier to secure and the code a bit more maintainable. Luckily you only have to do it once. There is a VM version that uses vmware and it works fairly well if you don't feel like doing a bunch of setup - just iTunes won't play nice with the VM edition because of static paths :/

3. the problem I found is that if you have a large library, the itunes xml can take a lot of ram to parse. If you're not using itunes, the RAM demands might be a bit lower.

I do hear you on the setup complexity. I think when I get closer to a perfectly stable program with developers familiar with buidling system specific installers, I'd like to build a slick installer that installs and spins up a server for you. For now there's the VMware image.
I remember after 9/11 happened and Stuy classes had to be temporarily relocated to Brooklyn Tech, all my friends complained about what a terrible experience it was (the relocation, not necessarily 9/11) and how horrible BT was (I was in Canada by that time and missed out on that whole thing).

It's a whole different level. Stuyvesant takes the 99th percentile of NYC students. It's somewhat instructive, but mostly unfair, to compare it to other public schools. What's really interesting is the parent poster's mentality - as if it's the money thrown at kids that makes top schools.

That's not an excuse for ineffective education, but money is not what is primarily going to change things. For starters, figuring out a way to make NYC public schools less like prisons would help.
The linked study backs what was said in the article. The addition of acetaminophen provides little to hydrocodone.

The side effects in this study are short term, with 1000mg of APAP. I don't think anyone is too upset about a single dose like that. However, taking it repeatedly throughout the day, or over extended periods of time, the APAP does cause liver damage. Hence the FDA review and possible ban on certain combinations.

However, the drug scheduling laws are real. Hydrocodone by itself is Schedule II, whereas hydrocodone with APAP is Schedule III. What other explanation is there for classifying the same drug in combo as a lower risk, other than that there's a damaging part to it?
Beyond the Call of Duty: Video games as art
My interpretation of the 'started to work' comment was that (they were claiming that) the algorithms had actually begun to detect the badness of the links (based on their structure or whatever) and they were starting to automatically be dispreferred; but that manual intervention had hastened the process.
40 bucks. namepros
Thanks.. I'll keep you posted!