skysight-inc/HackerNews huggingface dataset:
> At the end of the day, a $2B pharma company is still going to doggedly pursue a 20 year monopoly on a potential $1B drug, even if it otherwise would have been a $1.5B drug

The problem is they don't know it's a $1B drug instead of a dud until they've actually done the research, and most of the candidates fail. And since the successes have to cover the failures, if the successes make less money, they can't cover as many failures and you don't get as many attempts.

> Moreover, the vast majority of waste in healthcare is with hospitals, administrators, surgeons, insurance companies, and doctors, not the pharmaceutical industry.

It is certainly a multifaceted problem and there is plenty of inefficiency that could be improved. Not just healthcare, but also the plague of zoning rules that inflate real estate costs in cities. Which is where hospitals are for legitimate reasons, but hospitals not only need a lot of real estate, they also then have to pay salaries there that allow their (already expensive) staff to live within reasonable distances.

And the subsidy issue isn't just drugs, it's also technology. A lot of the "hospital" cost goes to equipment, which is the same subsidization of international R&D as drugs -- other countries with price controls not paying their share of the cost.

Which is why cost comparisons to socialized systems in other countries are so uninformative. Not only are they not paying their share of R&D, they typically have lower real estate costs, lower salaries across all industries, lower (and this one surprises a lot of people) taxes if you count "health insurance" as a tax, and it goes on.

There is a lot of pure inefficiency in the US healthcare system -- the level of bureaucracy is madness -- but a lot of its costs are also external to the system itself and symptomatic of healthcare being at the intersection of several independent sources of price inflation that each have to be addressed on their own terms.
Who cares? The terminal is a trusted system application.

This is a computer, not a phone.

Oh, wait, Apple's marketing...
I was so used to building SPAs and APIs, that it seemed the default to me. But I always felt it was slowing me down, I had to switch between multiple terminals, multiple editor windows, things had to be tested twice (on both FE and BE). I dropped that for just plain old MVC on the backend, and I find myself moving a lot fast now. I still need some JavaScript for things like dropdown, or the occasional AJAX call, but other than that, I actively try to avoid it.
I believe that some scholars actually believe that Pali is an artificial language, a mixture between different dialects that was intelligible to people from different regions.

There is no question that there are some later additions. There are even some contradictions. But by comparing different passages and comparing with the Chinese Agamas, we can get a pretty good idea of what the Buddha actually thought.
Too often, we're driven by getting the right answer. I care more about understanding -- figuring out what the answer means. As well as the difference between precision and accuracy.
It's becoming easier and easier to develop new products in this space. Hell, there are a few "open source" phone projects out there that are just white label products imported from China.

The first Neo phone was released a year before the first Android smartphone even hit the market. It's a bit unfair to compare these new projects with something like OpenMoko.
I'd personally rather it be secure by default than unsecure by default.
I did use AWS for good 5 years and every time it's been inferior, e.g. launching times of EC2 instances were double that of Google Cloud, better than azure though (might have changed with new instance type may be), N2 and N1 instances in gcp are usually faster in start, stop delete cycle than AWS as recently as last week. Networking stack between regional nodes is not as performant with higher latency than google cloud with its andromeda network stack, on top its more expensive than google and microsoft for bandwidth. Even though I put critical comments for GCP on this article, I feel AWS fare no better, indeed I feel its worse.

I have yet to see any good open source project by AWS team in the wild like Kubernetes, Linux Kernel Namespaces and Cgroups, Map Reduce from Google or .NET from Microsoft. So far what I have seen is that AWS just leech on other open source like PostgreSQL to build Aurora and RDS service without really contributing back to PostgreSQL, because postgreSQL comes with BSD license AWS can just leech on it. Same for elastic search and many other open source they leech on. I am still waiting if they are really just leechers or giving back to the open source community. Like Amazon Redshift is based on an older version of PostgreSQL 8.0.2, and Redshift has made changes to that version [1], but nothing is made open source because BSD license do not require it. This is just one big example but there are many. For open source community and contributions I feel Google and Microsoft are much better than Amazon and AWS by miles. It's just that due to early start AWS is reaping benefits by leeching on open source.

[1] https://docs.aws.amazon.com/redshift/latest/dg/c_redshift-an...
He does blown glass work, makes these amusing "Klein bottles." In my case, I am looking for a particular style of hourglass.
Firm releases cancer test kit that uses roundworms
If you can get SVP or above approval for the VIP pass it makes 98% of the security headache and digital city ingress and egress vastly more streamlined. I wont go back without one anymore.
As Dang said, indignation is boring. Great, you’re really upset how this doesn’t happen in the US (apparently).

That doesn’t add much to the conversation.
It was so infuriating to watch Democrats willingly get played by the religious right into supporting something that was so blatantly designed to legislate morality rather than actually help victims of trafficking. Glad that elected officials are now rethinking it, at least.
At least anyone who watches the episode today can't use that as a hint to bug you like I did nearly 30 years ago. :-)
Disagree. It improves signal to noise ratio.

I come to HN because the discussions often include a few gems where I actually learn something new or hear a perspective I hadn’t considered.

Saying that you’re glad SK is doing this is just noise.
The complexity context has to end up somewhere (or nowhere). JIRA is a superior tool in comparison to commit message text.
Less information means more bias. You may not have the bias that comes from misconceptions about the information on the resume, but now you have the bias that comes from assuming a "typical" resume whatever that is in your context.
What brand are the gloves?
My point is simply that the conjecture seems difficult to believe on the face of it, but that I would be willing to revisit my beliefs if Google actually made the claim. The fact that Google has made no such claim makes it more difficult to take seriously.

Edited to be more substantive.
Carpenter is a tricky term because wood is used in so many ways. This is strictly UK biased:

In building terms we distinguish a first and second fix carpenter. First fix is mostly structural and second fix is the rest. If your hair is wet its probably first fix - roof trusses and the like. Second fix will include things like skirting boards. It's not a hard and fast rule and will probably involve the same people. These trades are known as "chippies" (sing. chippy).

We also have cabinetry (your furniture smith - nice one) and other wood working trades. They are all called carpenters. A chippy is a carpenter and I think this a rare case where the nickname is more common than the real name. Civilians will often call a chippy a "builder". A cabinet maker is never known as a builder or a chippy.

The chippy thing is because a very small piece of wood is a "chip".

I think I know why you are a bit confused about the word carpenter. In the US and elsewhere, houses are mostly wooden. When a house is nearly all wood, then the word carpenter should mean builder. In the UK and elsewhere houses are built of sticks and bricks, mostly bricks.
I’m jealous that your environment is competent enough that commit messages are actually worth the time to fix.
code distribution I mean like cloudpickle. Which Ray has, but I wonder about an equivalent to Spark files (torrented and cached). A Kubernetes runner is also important ...

I wish the Ray peeps would consider just trying to merge some with the Spark RDD API. Reynold (at Databricks) is kinda hard to deal with, but so far to me it looks like the aim of having Ray team build things from the ground up has simply re-validated a lot of the systems work (but not all) that’s already in Spark.
those things were hilariously dangerous in the snow/ice. tons of fun :). I miss them too.
From childhood, the baffling 'ghoti'.

It's pronounced 'fish' [1].

[1] https://en.wikipedia.org/wiki/Ghoti
FWIW, WebOS works on it. Supposedly. I dont have mine yet.
> Sailfosh OS

I believe this should be Sailfish OS
The thing is, I can't/don't disagree with you, in terms of arguing for SQLite over alternatives. Hearing the practical specifics of your edge case is (depressingly) insightful.

I just realized the links I posted didn't include the article I had in mind when I went link-digging (and didn't properly check the results, woops). I found it: https://nolanlawson.com/2014/04/26/web-sql-database-in-memor...

Potentially interestingly, I re-found the link above via hn.algola.com, which also found me the comments (for the only time the above link was posted), at https://news.ycombinator.com/item?id=7661236. The top comment thread there points to https://github.com/kripken/sql.js, which was started pre-WebAssembly but now builds for WASM, and the network tab in devtools is telling me it's a 497KB download. It says it takes the position of providing a first-class JavaScript API instead of C bindings, and that you have to implement your own save/load<->import/export layer. You may have already discovered and discarded this possibility.

FWIW, if using SQLite does stick, I reckon that an article (even a small one) about the journey/decision process/implementation gotchas/etc - and particularly details about the use cases, and why SQLite shines for your scenario - would probably be received very positively.

Thanks for replying! (My fast response time was due to fun timing: I literally just opened my laptop this morning, checked HN, and saw your comment posted "0 minutes ago" :D)
I live in Northern India which has heavy air pollution. I recently bought an air purifier. Just the difference in the quality of sleep is amazing. And it is not a placebo effect. The filters are already visibly grimy. The PM 2.5 consistently now is around mid 20s down from around 180-190.

I would recommend it to all in North India who can afford it, esp households with small children.
Blight wiped out the American chestnut. Scientists are close to bringing it back
Wait, Plastic Can Be Good for the Environment?
A very abrupt turn (in London). Just a couple of weeks ago, they announced two-week rentals, and now they’re leaving.
I had an interview like that. I’m a marketer and my background is clearly B2C, and a hiring manager reached out about a B2B role. We chatted, had a fine conversation, then I had an hour “test” on lead scoring. I wasn't passed on, and told it was because I had no prior experience with B2B lead scoring...duh?
Empirically, the vast majority of those who hire sex workers are men. But yes, as I said, it's a gross over-simplification.

I would hope everyone opposes sex slavery.

In the progressive circles I'm familiar with in my midwestern city (Columbus, Ohio), I've never seen anyone make a feminist case for decriminalization or legalization. The consensus among progressives here is that sex work is bad for women. The voices I hear in the national media do tend to be ambivalent if not outright pro-sex-work, though, so I agree it's not simple.
Hyperloop Is the Midwest’s Answer to a Question Nobody Asked
It does not make sense. If you are installing untrusted software in your computer, all hope is lost.
It seems reasonable to claim (and seems to be backed up by authorities on the issue) that most genuine sex trafficking originates from two sources: 1) visa fraud and/or human smuggling across the border and 2) domestically, broken homes. Trying to fix either of these root causes requires stepping on some political landmines.
Until you switch bug trackers and the import process subtly mangles that link, and then you switch trackers a few years later and all hope is lost, and then five years after that you hire someone to fix all the bugs that you've been accumulating and they can't tell any of the reasoning behind anything you've done.

Are you always going to be on Jira? On Github? When people fork your project are they expected to clone your issues as well? When you migrate to another system are all your issue references still going to line up correctly? Did you even think to check?

Please continue to include the ticket reference. But also put some context in your commit message because that's what it's there for.

This is the same reason that even if you use a fancy documentation site, it should be generated from files in the repo.
None of my below rants are directed at you personally!

FF OS lives on today as KaiOS and is extremely popular in the devloping world where even an Android Go device requires far too much hardware specs for the price a given set of locals want or can afford to pay.

If you look at some of the devices that run it like the JioPhone, you can see that it sits quite comfortably in the space formerly occupied by the BREW systems of the world, but has little touches like email sending, Google Assistant, etc.

Edit: just to give some scale to the Android Go bloat (let alone plain old Android), the HTC Desire Z (https://en.wikipedia.org/wiki/HTC_Desire_Z) has 512 MB of RAM and a paltry processor, not powerful even for its day.

That device ran the current set of Android OSes at the time, and if modded today, can even be made to run Android KitKat, where official support stopped at Android Gingerbread. Today, that device is barely considered Android Go compatible, mostly due to its CPU and storage limitations.

In 2010, we took pictures, checked emails, played games, browsed the mobile web, performed calls, texts, IMs, watched videos, streamed music, and drove/bussed/walked with navigation.

Today...we do much the same things, but in a 'once more, with ~~feeling~~ AI` manner. There are very few totally new things compared to 2010, we just let mobile apps bloat up to web development-level bloat.

In my cynical moments, I look at the processing power eaten on my OS, wasted on wakelocks and ads and think to myself that somewhere, Ralphie is in the ~~Magic School Bus~~ cell phone factory and spinning dials saying 'more RAM, more CPU, more network speed, I don't know what to do, the software is all slow!' because every time he ups a spec, the bloat absorbs it without reducing user latency one bit.
I'm not sure what GP is referring to by "four characters", but in Mojave you can add Terminal to Full Disk Access in System Preferences, and I highly recommend it.

I assume Catalina would be the same, but I've never actually used Catalina. (And probably never will at this point.)
But this ruling means it can't be done ever again (barring a Constitutional Amendment).
Tim Cook is Apple's Steve Ballmer. The sooner they can oust him the better before the destroy the value of the brand.
You've missed a fairly large FOR - people who support freedom & liberty. The arguments against prostitution centre around its second order effects on greater society and is a crime with hypothetical rather than actual victims.

The argument that there should be a victim of some sort before criminalising something is compelling. It is difficult to argue that the prostitutes feel they are victims of prostitution without discovering that other crimes are already being committed without criminalising prostitution.

I have a much easier times justifying criminalising alcohol from principles than it is to argue against criminalising prostitutes, so I don't see why the one with obviously terrible second order effects is considered to be OK and not the other. We have to accept that we already tolerate a level of background things-slipping-through-the-cracks for the sake of liberty and general comfort.
It's so darned important to skip the step of asking the user if they want to make the file world, group, or user readable. So darned! I bet the guy who invented this has a patent and is a vp by now ....
John Nagel Sought Asylum in Netherlands Persecution by Clandestine CIA NSA DEA
Here's a video showing a microfluidic version of the valve made using shrinky dinks: https://www.youtube.com/watch?v=eNBg_1GPuH0&t=9m15s
> Many of those so-called garbage assets turned out to be great investments.

Because they were sold at garbage prices.

People buy recycled trash and make money doing it but that trash is still garbage.
It lets you bias the maze to make interesting designs at least: https://jsbin.com/betediceyu/edit?html,output (you might have to click "Run with JS" to make it work properly)
Let me flip that: why would you create more money when there's already plenty to go around, just that it's locked up in tax havens, and only used to allow the wealthy to live, effectively, for free? If inflation is a menace, why would we risk the absolute calamity that would occur if disappeared wealth was repatriated after we'd created a bunch more money?
> these are not exposed through the Finder interface

Just press cmd-shift-dot.
At that point, you’re going to need the in house expertise anyway and you would probably be better off managing your own data center.

Even if you are “cloud agnostic”, at that size just your networking infrastructure, compliance, auditing, and data migration is going to cost a boatload of money and it would take years to save enough to make the migration worth it. Not to mention the retraining and risks that come from the migration.

You probably also have a few direct connections to the cloud provider.
Lovely! Thanks for sharing this awesome-looking tool :)

edit: oh, it's also mentioned in the document slide 53 along with Flatpak
It's entirely possible that at Microsoft nobody cares and it's an unwritten rule that you can do what you want, while Google has explicit policies which have the effect of chilling things further when they don't work.

Let people do nothing and they will do whatever they want. Let people do a little bit and they'll be scared out of doing any more, for fear of having that little bit taken away, or being made to look ungrateful for what they were allowed. Which is exactly what happened/is happening to me, when cdibona banned me from the corp processes, and now when tytso etc are saying I should've been thankful.
> engineers aren’t recruited

Yes they are? Gift baskets, personal emails/calls from the CEO, offers of travel just to meet the team (not an interview), offers to fly out and meet with them. The whole nine yards. The number of people who get this treatment is small compared to the number of engineers, but it's not zero.
Coca-Cola documents reveal efforts to sell to teens, despite obesity crisis
I agree that ML on Spark was only a limited hit—- iterative jobs would actually be feasible versus Hadoop—- I still have yet to find a better ETL and SQL tool, and that’s a big part of most ML projects.

I’m worried about Ray as a SAAS Co because so far it looks to me like they’re riding reinforcement learning hype. They’d need to really penetrate the users of Horovod and Tensorflow Distributed to get beyond a beach head. And what if TPUs and Cerebras become more common? Because then the maker for multi-machine workloads becomes smaller (definitely not zero though).
Not reading resumes can be part of a process to efficiently discriminate by age, because it's precisely older people who have an interest in you reading a resume, because it's they who have important stuff there.
Amazing, thanks for sharing. Can I ask why you think SK is putting such a prominent figure in jail over this?

I mean this in the sense that, first you guys are doing the right thing and second I think here in the US we have a terrible track record of making corporate leaders responsible for criminal activity. I'm really interested in what systematic differences exist between us that allow you guys to actually hold the powerful responsible for their crimes?
Trying to impose "one way" to write commit messages is silly at best.

At work I follow whatever convention the team I'm on agrees with.

For my projects I use commit messages as a way to "tag" changes, more than to explain the changes using prose. That way it's very easy for me to search for changes in the codebase.

eg. #event-loop #fix #multiple-dispatch #repeated-message (remove the # and you get the idea)
I can't get these disk restrictions to work.

1) I granted full disk access to iTerm2. Later I removed them in the UI and I can still do everything in iTerm.
2) I have "Documents" granted to a Java app. Tried opening or saving a file in various locations and didn't notice any restriction other than my ordinary UNIX user's
3) I created an app bundle containing a plain shell script that reads my firefox cookie file and curls the file somewhere. This app runs just fine with no prompt whatsoever.

Am I being stupid here or what's up?
Are You Right for the Keto Diet?
I think they did a really poor job advertising this fact. The only reason I joined ZipCar was I had no idea about this policy.
arguing about the minutiae of whether google acted in accord with their own policies is exactly what google wants to happen here. She was fired for organizing. Google found a valid excuse to fire her but make no mistake, she was fired for organizing.
This comment gave me some peace.
Human trafficking is not the only consideration. There is health and safety of sex workers, issue of tying public resources to police voluntary victimless acts as well as just freedom to make choices about your life.
Prohibition makes all the above significantly worse. You would need a lot of compelling evidence it helps reducing trafficking to even get into a reasonable debate on it.
I highly doubt it was ever about trafficking to begin with. It's about various groups (on both right and left) wanting to tell people what they are and are not allowed to do with their bodies.
Calculus would likely not be invented without infinity. Many theorems, identities, and techniques may be approximated but ultimately rely on proofs using infinities - I doubt we would have discovered them quickly or at all without infinity. After all, the very concept of a limit evokes the concept of an infinite sequence.
Call for contribution for Rust&blockchain community
I might have to get one... I really miss this from my n900.
Steve Jobs the engineer. That made me laugh.
This reminds me a bit of hyperfiddle[0], which I've looked at a few times but never really explored. I know the author (dustingetz) hangs out around here, and I wonder if any of this interface builder stuff was prior art.

In any case, I wish we had more tools for interactivity these days. I use emacs and it's given me a taste for what's possible, and I'm excited to see Guix[1] mature because it has fantastic sympathies with emacs. But it seems destined to be niche, even though it's such a wonderful vision of what computing could be.

[0]http://www.hyperfiddle.net/
[1]https://guix.gnu.org/
People often forget all of Jobs’ failures and blame Cook for all of Apple’s woes. Jobs let many products stagnate, just the same as Cook.
Can you expand on “as Elon has done, over and over”, for those of us not familiar with what you are referring to?
Wood Working Plans for Beginners – 16,000 Woodworking Plans
Bulgarian language seems to me extremely phonetic, to the point I can correctly write and read words and I still don't know what they mean.
Can male sex workers be legalized then?
Toxic Chemicals Found in Rainwater and Drinking Water Throughout the U.S.