skysight-inc/HackerNews huggingface dataset:
I have performed DNA studies in my career. Measuring and interpreting methylation - understanding what it is, why, when and where it is present is at its infancy at best.

Sadly I have prime view how clickbaity ideas like this one drive most of the motivations behind investigations in life sciences.

It is not just this paper that is bullshit, the whole field of "epigenetics" that this paper is a representation of is bullshit as well - this paper is just one out of the long line.

As I pointed out it there is simply no proof that handling changes DNA. It could just as well handling stimulates the development rate which, in turn, also shows up as another signal.

The lie is not that A and B are present at the same time. The lie is presenting story as if A was caused by B. There is absolutely no evidence for that.

Now hundreds of scientists want a piece of the "cool" story, will jump headfirst into proving how LOVE will reflect in the DNA. No one will care about understanding what the heck is methylation - they will all be chasing baby handling and methylation. That's what I have seen happening and will keep happening thanks to papers like this.
Yeah, you have to fiddle a bit to get them to minimum width with the ">>" menu and no extra space. Obvious search is more or less good enough now, but you still can't drag from the start menu.
Thanks. I completely missed that legend. Does it actually scale linearly by cores? I would think there's a plateau after a certain number of cores.
SPA and all those javascript libs
I was surprised to find out that MyPy will throw an error if you use a variable to access a key (https://github.com/python/mypy/issues/7178).

Optional keys are also a nuisance.
Oh God, I'm that guy. I'd been following this elsewhere, so didn't actually expect I'd get new info from the link itself :/ [opens mouth, inserts foot]
There must be a better way – Raymond Hettinger (Python)
Do you mean something like this?

T1 = TypeVar("T1")
T2 = TypeVar("T2")
GenericUnion = Union[T1, T2]
This seems like a bad sign for Khan Academy. I hope they continue to exist but I'm not a fan of how they are asking for donations as a monthly subscription.
Location: Moscow, Russia
Remote: No

Willing to relocate: Yes (USA)

Technologies:

- PHP: Laravel, Symfony, Yii

- Javascript: Backbone, Angular JS, Vue.js, React, React-Native

- SQL: MySQL, PostgreSQL, Oracle, Microsoft SQL Server

- NoSql: ElasticSearch, Sphinx, Redis

- Docker, AWS

Résumé/CV: http://tiny.cc/NickIvanov Email: mrcool.ru+y <at> gmail.com

-------------

Senior Fullstack developer with more than 8-year background in web development, with excellent problem-solving skills. Strong knowledge of OOP principles, and design patterns. Extremely good in PHP, SQL, and JavaScript.
It seems that the content isn't included in the HTML in the page. Instead, the HTML loads some JS in a second network request. That JS is compiled and run, and makes a third network request to fetch the content.

Using server-side rendering might help get the initial page loaded faster.

The endpoints themselves also seem to be very slow. I clocked a page taking 800ms to just return the bare html (vs. about 90 ms for hacker news).
Indeed,

https://msrc-blog.microsoft.com/2019/06/14/prevent-the-impac...

https://security.googleblog.com/2019/08/adopting-arm-memory-...

https://kernsec.org/wiki/index.php/Kernel_Self_Protection_Pr...

Seatbelts and helmets are also a nuisance, maybe we should get rid of them, that is my perspective.
For Trump, instinct after Florida killings is simple: Protect Saudis
According to this[0] its react and redux

[0]: https://www.reddit.com/r/reactjs/comments/9e77jz/whats_every...
I think a lot of the issues stem from focusing on the mobile app, and not prioritizing performance of the web app (or possibly, deprioritizing the web app and expecting users to migrate to the mobile app).

I.E. I'd guess it's a business focus issue, not specifically the tech stack used.
In addition to cookie_monsta's answer, you also have to consider that a very sizable portion of microcredit borrowers live on a day-to-day or week-to-week budget. Often times income in will be lumpy whether from a paycheck every two or four weeks or because sales from their micro-business being lumpy as well (e.g. maybe they most of their money at the market on the weekend).
Would you use a web-based email client where, with one login, you can access all email addresses you care about? Not in an unified inbox, but have them as separates.

Say cmd+1 is quickly switching to address #1, cmd +2 is switching to address #2 and so on...
No, it's not. Streaming media is by far the largest consumer of bandwidth on the internet today. Latency doesn't matter at all for those.

Please see this blog for approximate cost estimates, or the MIT study comparing leo constellations.

http://tmfassociates.com/blog/category/operators/spacex/
Maybe fire up the dev console in your browser and run profiling? Or check out webpagetest, which has metrics like "time to first paint"

https://www.webpagetest.org/result/191208_BD_0e906d662819138...
There are several large terrestrial telescopes that use assemblies of a number of coordinated smaller mirrors.

This looks like something reasonably doable on Earth orbit with the current launch capabilities.
Tons of glitches.

- You click on a post. Comments don't load. Click the 'reload' button repeatedly, comments still won't load. Hard page refresh fixes the problem, but if you were in a modal, you've lost the context to where you were in your subreddit post list.

- Click on a post. It doesn't exist anymore (mod removed, etc). What's odd about this, is the post's body is loaded, because in the list view, you see a preview of the body. But in the modal, it won't even show that. The information is already loaded in the browser, but it won't display it.

- Searching: results temporarily display as "no results found", then load. This sounds like a simple one to fix. They logic must say "if 0 posts, show a 'no results' message". Except, we're waiting for the API response. It's a bit presumptuous to say our query resulted in no data, if we didn't even receive the response yet.
Generally this is how natural selection works, incrementally over long time scales. Just a small bias for survival is enough to get the optimization process to work over the long time scale.

One other thing to think about, one strategy that bacteria have been observed to employ is that a colony can clump together and develop a kind of film that protects the entire colony from some chemical that would be fatal to any one individual cell. This ability is greatly enhanced by individuals having a greater tolerance to low concentrations and being able to signal to the colony to begin the defensive response. Bacterial colonies have also been recently shown to communicate amongst the individuals.

So, the headline could be reasonably construed as accurate, IMO.
That's crazy. By the way it probably even is possible to fingerptint a user by their mouse moving patterns.
Even more tragic is seeing what has happened with the imgur-reddit situation. Tapping on an image in the reddit iOS app takes literally 4 or 5 seconds to display.
Not that I think react+redux was a particularly great choice for reddit (given that it's mostly just static content), that post doesn't justify your conclusion that this is the bottleneck at all...

(But is new reddit slower than old reddit, in the first place?)
So how many do email addresses would you need to access if, say, you're on a vacation and you're using the hotel iMacs (or whatever desktops they have there).

When you get a new phone/laptop/work computer/etc, do you set up all these 2/3/4 email addresses you actually use, making sure the display names and signatures are synced?
I have been teaching kids games programming with Python. I have compiled some of the material I created into a book here: https://github.com/electronstudio/pygame-zero-book

The only way I have found to maintain interest is to do fewer toy examples and more full-size games, but that also inevitably leads to the kids not understanding so much of what they are doing. I think ultimately you have to accept that some kids will be interested in coding and some will not, no matter how 'fun' you make it.
Interesting, thanks for the hint.
Not OP but it is unberably slow. It took 9 seconds acording ot firefox for it to stop making network requests. That is me opening reddit.com without doing anything. Then another 3 seconds for me to click a link and have it load the new page.
The user experience on mobile is hilariously bad.

1. Google search turns up a reddit result.

2. Click link to AMP page.

3. Scroll to read comments and click another link to open real reddit to view all comments.

4. Get to real reddit domain and watch a long loading screen.

5. Click away 2 notifications saying you should use mobile app.

6. To read a child comment, click again to read below. Page reloads above the parent comment causing you to search the page again to see child comment.

Absolutely ridiculous but still I do this because most Google results are SEO garbage. Google disabled conversation only search. Reddit is unfortunately still the best way to get a real person's view on a topic that most likely not an ad.

Just like with digg, we need a new reddit.
Why doesn't V/Y offer to provide some 'meta retrieval archive service' for some amount o $? I mean, $ is what they care about so ...
There are very few "AI companies". True AI companies are research labs like DeepMind and those AI consultancies. Both of these make money from PR and hype. Other than that, some video/image analysis and processing companies, e.g. face recognition solutions, come to mind as exceptions. The other kind of company that depends on the recent AI developments is infra. They are selling the "shovels" for others to buy into the hype.

Other companies that brand themselves as AI do so for PR purposes. Most of them don't use AI, use robust techniques that have been around for many decades, or use it only to justify their pitch. Their product would be just the same with rule-based systems or without any kind of ML.
Politicking aside, I wish all the leaders in all the countries of the world held such ideals as this man.

There's a lot to absorb, but the rising alcohol and domestic abuse due to despair is something that's increasing in my country too: oz. Mental health issues are skyrocketing. Our politicians ignore what we ask for, but propagandize what they think we need based on their corruption, while actively suppressing liberty. The middle class is almost gone...

... and we're widely regarded as being called the lucky country. By comparison to many less fortunate others we still are.

Edit: typos
I recommend using the old.reddit.com subdomain, it's better and less javascripty.

Also install this to always use the old subdomain.

https://addons.mozilla.org/en-US/firefox/addon/old-reddit-re...
Oh, just for fun, I manually replaced the BLIS libs w/ the AMD BLIS 2.0 fork (Ubuntu MT binary on an Arch system: https://developer.amd.com/amd-aocl/blas-library/) and it seemed to work ok. Slightly faster than BLIS 0.6.0 but not actually faster than OpenBLAS on this test...

## AMD BLIS 2.0 https://developer.amd.com/amd-aocl/blas-library/
# conda activate numpy-amdblis
Dotted two 4096x4096 matrices in 2.33 s.
Dotted two vectors of length 524288 in 0.08 ms.
SVD of a 2048x1024 matrix in 0.78 s.
Cholesky decomposition of a 2048x2048 matrix in 0.23 s.
Eigendecomposition of a 2048x2048 matrix in 5.84 s.
I just visited a SubReddit, turned off all my anti-tracking and adblock extensions and compared:

Old Reddit:
51 requests
3.87 MB / 1.14 MB transferred
Finish: 4.83 s
DOMContentLoaded: 1.96 s
load: 3.69 s

New Reddit:
185 requests
13.70 MB / 7.44 MB transferred
Finish: 12.99 s
DOMContentLoaded: 2.38 s
load: 7.80 s

Key Takeaways:

Use less Requests. Every request can fail, or have latency too it which can slow down pageload in general.
Use less JavaScript, while necessary for some stuff it can easily bloat your website.
Also, don't load shitloads of CSS, keep it simple.
Think about fonts, do you really need several of those from external servers or do system fonts and defaults do a good enough job?
It's pretty easy in those regions to lend so the fact that loansharks still dominate seems to indicate to me that they're lending to unreliable borrowers. i.e. that this is market equilibrium, you cannot compete on margin.
When you're on a computer, do you access all these individually from the browser?

If you'd switch your phone, does the need to sync the display names and signatures bother you? That, and the need to log in manually to all these 6 addresses?
By the way, isn't there an open-source desktop-native client for reading (and searching through) Reddit?
New Reddit is horrific. If they ever get rid of old reddit it will cure me of my reddit addiction for good.
Hoping i can get an answer here from somebody who actually knows, and not just a spacex fanboy or hater: what's the actual scope of the problem here?

Shotwell's response and other comments i've seen seem to imply starlink satellites are primarily impacting amateur astronomy ("kids looking through telescopes") and that scientific research is performing post-processing to the recorded images which can mostly eliminate the effects of the starlink satellites. Is that accurate, or is this also impeding telescopes at the big observatories?
Not sure why the parent is gray, except maybe the scare quotes around "journalist". You absolutely can influence the narrative with your choice of which 10 stories to run of the 100 you have.
Well it sounds like it wasn't lucrative or fun.
The ground system is what will make or break starlink. Every phased array antenna to date is at a price point that would put starlink selling exclusively to enterprise customers. This means consumers won't be able to get it unless you're in the 1% and living very remote.

SpaceX will not realize 20Gbps per satellite in useable bandwidth. It's more like 5Gbps.

http://www.mit.edu/~portillo/files/Comparison-LEO-IAC-2018-s...
They're using Python and webpack. Not sure what they were using before and unsure if Python is really dragging them down, but I like their design (although watching videos on mobile and going through posts on desktop is extremely gimmicky and buggy).
Freedom in the 50 States 2017-2018 – Cato Institute
Chi-Rho is not at all the source of the name of the city Cairo.

Cairo was founded by the Fatimid's and called al-Qāhirah, and this is the etymology of the anglicisation.
Yea, but there is definitely a gradient or propensity of evidence that is often lost. For instance, touch transfer DNA can deposit your DNA on a crime scene if you interacted with the EMTs earlier in the day (Anderson case, 2012) [1] which means very little, but if a suspect's fingerprint is in the victim's blood, it's very likely the suspect was present during an attack. In the later case, I think DNA evidence, the victim's in the case, would be evidence of guilt, but needs to be part of a larger, coherent case.

[1] https://www.forbes.com/sites/marinamedvin/2018/09/20/framed-...
In Russia, there is no judicial system. Courts are simply rubber stamps for Putin run mafia, they do the bidding of the boss. So if repressive machine wants to crush someone, it would do it without hesitation, using hundreds of anti-social "laws" passed by the fascist Duma (parliament), that does the bidding of the same boss.

Basically courts do nothing in practice, just pass "judgements" that are handed to them by the "investigators" or whoever relays the mafia command to them. And if the boss decides that public would react too much to the court case, the "judges" might suddenly become more lenient.
This. I would gladly play a bit more for acid-free paperbacks that don’t turn yellow and brittle.

I am concerned what my current book collection will look like in 10-20 years, and for this reason have been considering hardbacks over paperbacks (which isn’t always better quality but there is some positive correlation there).
Here is an answer that implies bacteria are evolving copper immunity: https://www.sciencedaily.com/releases/2016/03/160316130951.h...
Gmail already allows to easily switch between accounts.
Pyflakes and a test or two will weed out trivial errors right away. Getting to zero errors takes more work however and that's where mypy has a place.
Do the Twitter TOS allow mandatory follows like this?
Streaming uses lots of bandwidth, but it's not necessarily the majority of browsing activity. High latency is painful if you're doing things like browsing Reddit.

The blog you're citing claimed Starlink was getting canceled a year ago, so I'm a bit skeptical of its use as an oracle.

http://tmfassociates.com/blog/2018/09/18/420000-km-funding-s...

> Another hint that Starlink is going away was the statement that BFR is expected to consume the majority of engineering resources after the commercial crew development has been completed for NASA next year, despite Starlink supposedly costing more to develop than BFR ($10B+ compared to ~$5B) over the next 5 years.
Would you use a web-based email client where, with one login, you can access all 3 addresses?

Not in an unified inbox, but have them as separates. Say the "cmd+1" keyboard shortcut is instantly switching to address #1, cmd +2 is switching to address #2 and so on...
For some, I automatically change my "from" address using a rule in mutt, that change it based on the recipient. One could keep a list there I guess.

For social media etc., it hasn't come up for me, but for those or multi-contacts sharing it, I would have to choose a shared email I guess, or use a main "business" one. (I don't personally use FB, or those sites that have you log in using contact from another site. Fortunately my activities have been able to work around those.)

I do keep a log in my personal organizer of what # comes next, and what address I have used w/ whom (with my notes for each org I talk to, alonside the contact names, physical address, conversation logs in case I need to quote who said what when, etc). Then I try to use the same email address w/ them when I reply (a few keystrokes I learned, in mutt; this has not been often enough to be a pain, so far, but I can see how it could grow to a nuisance if I were doing that all day long). Maybe one could extract the email addresses from that list and use a bulk email every 3 years to say "here is my new address" or something, if that address started getting too much spam. I haven't done that to know if it is practical from a social standpoint: maybe not.

Arguably at some level, it could be all more trouble than it is worth. It's become habit for me now. I guess I get annoyed when someone requires my email then abuses it, or I start getting spam of a type that I know their PC was compromised. At least once I got some really offensive spam from an address I had used only at an online site whose services I appreciated, but whose IT I couldn't trust much, because they claimed they had notified all customers who were compromised in a reported breach, but they never notified me. That knowledge might not have benefited me enough to justify all this work, but I was really glad to block that email address in future. Once I skipped my usual careful process and instantly regretted it (fortunately that spam has since petered out). Or, I can now auto-delete emails from public mailing lists I haven't used in many years but spammers still do.

I also have one "throwaway" address I re-use for all businesses where I don't care if we lose track of each other, and I can change it later if needed. That might be the sweet spot for some.

edit: Having my own domains lets me do it however I want, and change over time.
Would you use a web-based email client where, with one login, you can access all 5 addresses?

Not in a unified inbox, but have them as separates. Say the "cmd+1" keyboard shortcut is instantly switching to address #1, cmd +2 is switching to address #2 and so on...
Would you use a web-based email client where, with one login, you can access all three addresses?

Not in a unified inbox, but have them as separates. Say the "cmd+1" keyboard shortcut is instantly switching to address #1, cmd +2 is switching to address #2 and so on...
what matters is that there might be more search results, not their precise number
The common thread is corruption.
Cómo Arreglar DNS_probe_finished_nxdomain En Chrome (7 Opciones)
I've had a few books disintegrate in my hands. I was the last one reading them because the pages would come off as I turned them. Those damned paperbacks.

If I want a truly disposable book I can read the electronic version.
I'd bet this has less to do with developer incompetence or frameworks and more with the Peter principle(maybe even the Dilbert principle) inevitably causing orgs to be run by boobs who hand wave about features and redesigns under ridiculous timelines.

I can just picture the board meetings where some poor soul did a presentation of the "new reddit", and one of the bozos saying "That's great, but how will users know that we have a mobile app? Can you add a banner to annoy them into using the app that they don't need? There's a company that promises the greatest analytics in the world ever. You can add their tracking pixel, right? We were wondering about tracking the user's mouse movements. You can do that, right? We hear that JavaScript is the big thing right now. Are you sure we have enough of it?"

DEVELOPER: Sigh.
Verizon's response, and the response to the response, are in the article of the OP. They claim they offer a Group Downloads Manager, but it's very broken.
Adoptive parents are people who have gone through a lot of effort and expense to get their children, so they're far more likely to be heavily invested in their kids. It's also expensive so they're likely to have money. If the effects of parenting are strong, but "cap out" -- i.e. above a certain level of care, parenting does little, but before that level it has a strong effect -- then twin studies will show little of that effect.
> The white-robed wizards of Silicon Valley now ply the black arts of algorithmic witchcraft for power and money. They wanted most of all to be Gandalf, but they became Saruman.

I don't actually recall anyone proclaiming the messiah-ness of these guys and the inevitable social justice juggernaut of Google back then. It was a better search engine. they (justly) got rich off it. If the author had more hope of what "the Internet will mean to Mankind" back then and is dissapointed in what he's got now, perhaps he shoulda jumped in then or even now, and fix it.
The default GC's do already behave this way. They don't run GC on exit. Why on earth would they?
reddit has been intentionally making the web experience horrible with multiple popups and hiding comment threads, pushing users to use the app and log in. so it makes sense that overall performance is also bad. for a better experience use the app! ugh
In theory you could do it directly with the intrinsic system I built for LuaJIT[1]. It would dynamically generated the assembly for a user declared intrinsic\arbitrary machine opcode when there first called in the interpreter and the opcode is directly emitted when the code is JIT'ed. I think defining an intrinsic for a system call would just be a matter of setting the correct input and output registers.

[1] https://github.com/LuaJIT/LuaJIT/pull/116
They will last a long time of Sal Khan doesn’t keep raising his f’ing salary. 2017 he made over $800,000.

You can see everything on their 990: https://pp-990.s3.amazonaws.com/10_2018_prefixes_26-27/26154...
The simple answer is that is what most people buy. For some types of books—uncomplicated genre texts—ebooks have a significant market share, but for much nonfiction they don’t.
The irony is pretty rich here, because Masha would be happy to see an identically situated American (ie, a libertarian with a flag of violent resistance to state tyranny expressing concern about demographic changes and attempting to form non-state mutual support networks) suffer a number of legal and extralegal consequences.