skysight-inc/HackerNews huggingface dataset:
I'm not an expert but I believe that one of the key advances here is that this technology can introduce new DNA via more precise mechanisms, breaking just one DNA strand at a time.

Current CRISPR tech involves "double stranded breaks": cutting both strands of DNA. The body has a few ways of dealing with and repairing these breaks, one of which scientists can use to insert new DNA of their choosing [0]. However in other cases the cell uses a different repair pathway that can introduce mutations (including insertions or deletions of DNA). These mutations can be harmful especially if for example they mutate a tumor suppressor gene

The new approach here apparently has less of a risk of introducing these mutations bc it does not cause double strand breaks, so does not trigger potentially erroneous repairs that cause harmful mutations

But I'm not an expert so if this is incorrect or if I'm missing something please chime in

[0] https://blog.addgene.org/crispr-101-homology-directed-repair
You and everybody else. Japan's current situation seems to stump most economic models.

I wonder if there's something about culture and having basic survival needs met. Most economic models assume effectively unlimited long-term demand: as productivity grows and people in existing sectors are thrown out of work, they will find new things to do, and the people who have reaped the financial rewards of productivity growth will find things that they want to spend money on, creating new jobs for the previously unemployed. What if this doesn't happen? What if instead of using money as a means to an end, people use it as the end itself, effectively treating it as a scorecard to be maximized without spending it? And what if on the other end, instead of people finding new ways to obtain money, they opt out of the economy instead, creating alternate games (literally - video games are apparently the main extra-economic outlet) to play. With basic survival needs taken care of by parents, there's no forcing function that makes them participate in the economy. You'd get a reality that looks fairly similar to our actual reality, in Japan and increasingly in other developed areas of the globe.
Please share the model, thanks.
Hi, I'm the author of the post. We actually just presented this work and more at PyData NYC. We share more implementation details. Here are the slides: https://www.slideshare.net/AlexEgg1/discover-yourlatentfoodg...

But to answer you question here: For production ANN we have Annoy integrated into our backend as a service. Annoy was an easy choice bc it checked out box for JVM support.

For training the models we have endless amounts of behavioral data, so we didn't even need to look at transfer learning. For this query2vec example, it was trained on 1 year of queries which takes 15min/epoch on an AWS p2 GPU. We do all our preprocessing (heavy normalization) in pyspark.
Thanks! any plans to make it faster? Like talk-to-transformer? Seems much more slower
Contrary to what he thinks, I do believe I have improved since I began, albeit not to the level he wanted. The "should know X by now" quote has bothered me, though, where I have asked myself his question in my own head.

For the most part he seems okay around others, but there have been a few times where I think people have picked up on his attitude.
> I don't buy mindfulness in the slightest

> I write down important things that are nagging at me

Sounds like you buy it at least a bit.
I had the exact same situation as you out of university. Except my SO moved to the city with me. If we were separated, I would have either:

a) Broke it off

b) Moved

c) Asked her to move in with me

I'm so glad I didn't have to make that choice. It would have crippled my career (leaving the city). I hope it works out for you and the relationship is worth any possible career damage.
...clearly we're not going to agree on this. Yes, I indent code, but—while I've never thought about this before—I actually think using carrots could work equally well! I'd add one carrot per ident level to the start of every line.

Back to quotes, for multiple paragraphs, I just add a ">" to the start of each paragraph.
PowerPoint Programming
Some Robinhood users were able to trade with unlimited borrowed money
This kind of stuff is frustrating to me.

Projects that respect their customers are usually on the edge of oblivion because they don't have a profit or ownership motive.
But they are vulnerable to others copying and cost-reducing their work. Customers usually choose the cheaper copy.

Projects that are sucessful assure themselves a profit by closing their products and restricting things. Customers are limited in what they can do, or have to be content with buying a crippled product.

sigh.
Indeed. Its all about control, or the perception of it. And the simple fact that its just another thing to monitor and manage. Many never realise this and become slaves to their feelings. Feelings are not core truths, they are just data.

Of course its completely reasonable to feel exasperated and angry about things that are out off line with your value system. But knowing this is directly related to the distance between what is real in the world, and where your value is set, gives you enough information to work with.
Is there a non paywalled version of this article anywhere?
`get` will destroy type inference, there's no workaround. Your output types are always `any`. The new optional chaining fixes that problem, giving you the same terseness as `get`
Often blindness is one of many disabilities a child may have. If a child is severely impaired basic skills such as the ability to dress and feed them selves are a lot more important then the ability to read braille. I’d like to see these statistics broken down in a way that considers individuals with multiple disabilities.
It seems like this time around, everyone's on edge about a coming crash, and they've already cashed out a good amount, with intent to buy back in when everything's on sale. Wouldn't this have the effect of turning a would-be crash into a minor correction, because there'll be so many people ready to buy?

I'm one of these people that's sitting on more cash than stocks at this point, by about 4x, but I'm starting to question this choice.
Instacart Workers Are Striking Because of the App’s User Interface
The problem is that gold is not a hedge against market risk, it’s simply (mostly) uncorrelated to equities. If you’re specifically trying to mitigate the possibility of a large market downturn, gold isn’t necessarily going to help you at all. Instead you should look into assets that have a negative correlation with equities. Bonds are a good choice but are more strongly correlated than they once were with the market. Or you could go witb some sort of portfolio insurance: VIX futures, index puts, or whatever. I personally wouldn’t recommend them though because they are almost always a rip-off (more natural buyers than sellers).

On the otherhand, if all you’re looking to do is lower your volatility, gold isn’t a bad choice. Whenever you diversify into different investments you alwaya reduce volatility as long as the correlation is less than one. Though if that is your goal, maybe consider investing in many different metals, as well as crypto.
I know its at least a year out but I'm personally looking forward to the 600Mhz 5G rollout - theoretically the range will be unbelievable. I don't want gigabit speeds when I'm 50 feet from a tower, I want 10mbps wherever I am!
I’d buy fair trade drugs if I could
Also he picked his position because he thought apple was overvalued due to having too many female execs. Even if we concede his point, that should be priced into the stock already, no?
Not an ideal solution but you may want to look at prepaid credit cards. In my case, I use USD prepaid cards via CIBC for SaaS subs. https://www.cibc.com/en/personal-banking/prepaid/cibc-smart-...
One could say the same about workers in food production, low skill manufacturing, natural resource extraction, etc.
> There was no "peer review"

Further, social media posts like Tweets are _more_ “peer reviewed” than old-timey revolutionary pamphlets: you don’t have much reach on the platform unless people are re-tweeting and following you, so only popular (though not necessarily good) posts get any distribution.
Sorry to hear that and I agree with your sage advice to be careful.
Monetizing debt makes both your currency and your government untrusted.
If consumers engage with these influencer/brand combos we'll certainly see a new wave of younger influencers enter the social media game. With how young folks are getting on the internet too definitely shapes their consumer habits. I am a millenial and have felt similar "connections" to content creators back when podcasting hit off (Diggnation comes to mind). I used to consume everything Kevin Rose/Alex Albrecht because I thought their lives and ideas were so cool. Now nearing my 30s I realize I was imagining my own startup pipe dreams. Can't help but think this is amplified with younger folks consuming daily vlogs, instagram stories and more. Interesting thing to study in the future, for sure.
You’re young. You can weather the storm. Your parents should have been bond heavy if they were close to retirement.

My portfolio was down 33% in 2008. That loss was quickly reversed with the 8% on average returns over the last 10 years.
I've never felt better.

I can count several years that were the worst of my life and it didn't make sense to go on -- my first year of graduate school when I got my life's worst grades, my girlfriend left me, I didn't have time for my hobbies, my roommates didn't pay bills in my name and broke my things, etc; also the year my first company almost wen bankrupt and I felt I couldn't trust anyone. Those experiences and getting out of them put my problems today in perspective.

I jump out of bed every morning. I love my work and the people I work with http://joshuaspodek.com/podcast. I'm passionate about my projects. There are hard challenges, but taking them on is the source of my purpose and gives me meaning.

I often feel bad and in those moments I wouldn't write like this. Sometimes I feel like giving up, but past disasters and my lessons from them tell me those moments will pass. My practices of regular exercise, a healthy diet, and sleeping a minimum that's right for me most nights are a solid foundation to build on.

I wrote my books on the NYU courses I teach that develop this lifestyle https://www.amazon.com/Initiative-Proven-Method-Bring-Passio... and https://www.amazon.com/Leadership-Step-Become-Person-Others/....
>Just be sure to not be too strict in your tsconfig.json in the beginning.

Do you mean to avoid using the "strict" rule, or are you referring to other rules? My number one Typescript suggestion is to make sure you start with "strict": true in your tsconfig.json to be sure your code has nullability correctly enforced.
Some multiple larger than one of the estimated amount of money they made by lying.
It doesn't seem, from the descriptions, to be possible to exploit this bug without knowing that you're doing it. It's not like they simply don't enforce margin limits; in fact, it looks like you have to apply the bug iteratively to do anything interesting with it. That being the case, it doesn't appear to me like the people exploiting it will have any way of talking their way out of the intentionality of their actions, at least not to a "reasonable person" standard that would be applied in civil court. It looks like cut-and-dried fraud. Am I wrong about that?
I find that a goal for exercise helps a lot. If jogging is your thing then sign up for a 5k(or longer if that's where you're at) and then set a goal time and training plan. Seeing improvement over time is what helps me. Even if I don't feel like I have control over my job or feel stuck in my career, I can at least improve my fitness. When I'm aimless in my fitness goals then I'm less motivated to do it and if I do get my butt off the couch then I'm less motivated to work hard while I'm training.
Also want to mention that it works with Ruby-on-Rails apps and can serve as an instant GraphQL api for your existing Rails app just deploy it alongside the app. Super Graph can decode rails cookies and work with rails session stores to fetch the user id.
I separate copyright from the rights of an owner over an individual copy.

Think of it like a physical book. If I buy a physical book, I have the right to rip pages out of it, or rebind it with a new cover, or even scan it as a personal backup.

I also have the right to resale, so if I buy a book I can sell it to someone else, even if I've modified it (although I would need to destroy all of my own backups).

What I can't do is scan the book and start selling copies of it. That's covered by copyright.

In the same way, allowing someone to reverse-engineer and modify Photoshop, or even to share instructions on how to modify Photoshop, does not mean that they can turn around and start hosting copies of Photoshop downloads on their own servers and distributing them for free or for money.

Existing laws in the US cover this fairly well -- the problems I have are with EULAs that try to ban owner rights to modify their own software, and with the DMCA which makes it illegal to break DRM or tell people how to break it even if you're breaking it for a completely legal reason.

I don't want to get rid of copyright, but if you sell me an Kindle Ebook, and I break the DRM on that book to get it to load on my own Kobo reader, that should be legal. I don't believe an author has the moral authority to block something like that. It's not an obligation to distribute the source, or to allow anyone to do literally anything they want -- just to say that if content/code is executing on my device, I should be able to look at it and manipulate it. Once it leaves my device and re-enters the public sphere, feel free to start enforcing terms.
If you speak with authority on a subject you will probably get downvoted if you are wrong about it. At least one of either humility or accuracy is expected.
Citing a logical fallacy doesn’t make a statement false. There’s numerous sources supporting this(note that these are 3 different surveys from 3 different sources from 3 different years all showing the same result):

”Nearly nine out of ten, or 86 percent, of millennials (those between the ages of 22 and 37) would consider taking a pay cut to work at a company whose mission and values align with their own, according to LinkedIn’s latest Workplace Culture report. By comparison, only 9 percent of baby boomers (those between the ages of 54 and 72) would.“

https://www.cnbc.com/2018/06/27/nearly-9-out-of-10-millennia...

“At least those are the results of a new survey out from insurer MetLife, which found that nine out of 10 people would choose a company with similar values over a job that pays more. And they are willing to take a pretty big pay cut to make sure those values align with their own.

The average pay cut employees were willing to take was 21%. The findings were not limited to high-wage earners: People who made less than $50,000 a year also said they still were willing to part with at least some of their salaries for the right company.”

https://www.usatoday.com/story/money/2017/11/29/money-no-lon...

”Almost half the workforce (42%) now want to work for an organisation that has a positive impact on the world, according to research carried out by consultancy Global Tolerance. The survey of more than 2,000 people in the UK found 44% thought meaningful work that helped others was more important than a high salary and 36% would work harder if their company benefitted society.

The change, it would appear, is being driven by the so-called millennials. Of those born between 1981 and 1996, 62% want to work for a company that makes a positive impact, half prefer purposeful work to a high salary, and 53% would work harder if they were making a difference to others.“

https://www.theguardian.com/sustainable-business/2015/may/05...
Is the name inspired by the building in C&C Red Alert by any chance?

https://cnc.fandom.com/wiki/Chronosphere_(Red_Alert_3)

That’s my personal reference to the word, but searching around a bit, it seems that it was registered as a trademark by a medical company already in 1991, 5 years before Red Alert.

https://trademark.trademarkia.com/chronosphere-74147725.html
i have a question: would it be illegal for me or anyone else to access it, copy and paste it somewhere else? this sucks
Eh, if I did this and I came up in the black off on a play with $1M in free leverage I would just close the position, pay off the margin and dip without posting about it. If like five people posted about it and lost money, there are probably a couple winners who are lying low, even just completely randomly assuming the traders have absolutely no signal whatsoever in their choice of play.
It seems like the original blog post got it wrong there. See the comment by "godspace"[1] and the link they provided[2]. The | indicates a line break but the ︙ indicates a logo.

[1] http://widespacer.blogspot.com/2016/03/the-lost-key-of-qwert...

[2] https://www.newspapers.com/image/39396241/?fcfToken=eyJhbGci...
My thoughts exactly. This reads like a political hit piece tailored for an HN audience.
No One Should Buy the Facebook Portal TV
Just out of curiosity, where does the money from a fine like this go?
NoScript worked for me.
I’m not blind but very visually-impaired and couldn’t agree with you more about computers. The iPad and eBooks have been an absolute godsend for me — I still remember the old days of getting unwieldy enlarged physical books. Now it’s so much nicer!!

When growing up I had to prepare for the possibility that I’d go totally blind one day (thankfully that did not happen). One of the best things that was ever done for me was getting regular touch-typing lessons from a young age.

On screen readers - I’m really excited to see what ML could bring to the table here. I think accessibility could be increased greatly with an ML that could recognise what was happening on the screen based only on the contents of say, the last few seconds of frame buffer data.

I’m also really excited for what AR (augmented with audio in particular) glasses and the like could do here too.
One only has to look at which viewpoints get censored to get a pretty good idea which ideas the pro-censorship crowd thinks are the dark, dangerous and evil ones.
Author here. Thanks, for the recommendation. I actually got inspiration for this idea from chatting w/ industry colleagues at SIGIR. Last SigIR in Paris, I spoke to some people from Apple, where they are using a technique like this for the app store search.
Yeah sounds like it's his problem. Maybe he sucks at on-boarding, or maybe he's over-worked and it's easier to blame the underlings. Hope it doesn't mess with your head any more.
Does Stripe have a public WebSocket API?
> A battery back up of solar and wind deployments on the scale of a nation's economy, would need to provide enough storage for WEEKS of energy - there is NO battery technology today or upcoming that can do that.

With a sufficiently broad definition of battery to include pumped hydro, grid scale batteries do exist and are cost effective. This does require rather specific geography.
I'm talking about "noImplicitAny", "noImplicitReturns", "noImplicitThis"... they get in my way when I'm editing. When I'm about to push my code I activate them back.
I don't know you at all; so I'm going to give you a piece of advice that helped me when I was a young sysadmin, and I'm going to hope it applies.

If you join an established company, in the beginning at the very least; that company has the responsibility to give you focus and training on the requisites. The only times this doesn't apply is when you are a senior, joining management, or creating a new team entirely.

If you're an individual contributer for an established team, you should feel empowered to push back, because as long as you are attentive and put effort in; you can do no wrong.

They hired you, for your skills, for your attitude, now it's up to them to facilitate your work if they want it. Never feel ashamed for not knowing something, for it is their responsibility to have given you that knowledge. Never feel ashamed of not having work to do, for it is their responsibility to feed it to you should you be able.

The blame is never on the IC, unless they're not trying.
It does preserve their rights to choose to do whatever they want. The statistics bear that when given the choice of access to the services, women will statistically choose them, and also voluntarily, and without solicitation, choose to have fewer children. I can't see an evil force here that is infringing rights of nefariously undermining anybody's freedom.
IANAL but I think so
> If you're already rich, which I assume most hired CEOs are, why is prioritizing money over people a more rational decision?

Generally, a non-founder CEO is a ferociously competitive person--probably to the point of being pathological. They often "play poker" in situations where there is very little upside to doing so.

Great salespeople are often the same way, they simply can't turn it off.

You are asking a leopard to change his spots after he has started eating the antelope.
One imagines a similar middlebrow dismissal lobbed at those flying camera drones that started selling for personal use about ten or fifteen years ago... We already had UAVs; why would anyone think multiple tiny electric rotors were better?
the whole article is inside the page, only hidden by a <div>

Use the source, ctrl-f and search for "background: linear-gradient(rgba(255, 255, 255, 0)" and delete the whole div that contains it.

You are welcome.
Armley Asbestos Disaster
This makes me think of https://ansuz.sooke.bc.ca/entry/23
Worked instantly on iPhone safari with a content blocker. Was surprised to see someone write paywall, because didn’t think my setup would block one.
I answered this before but can't find my post (is there an easy way to search your own comments?)

Basically I said put pressure on your politician. As an individual you can't do much, a politician is the person to make things happen - it's their job! - so pressure them.

I'm currently doing this to my own (in the UK). They seem to be struggling rather pitifully to understand the difference in priorities between Brexit, and a Catastrophe of Human Making aka climate change. Well, FWIW I'll keep pressuring them.
https://web.archive.org/web/20191105095737/https://www.lrb.c...
Prescription drugs? Because I need some and it takes months and time off work and repeated Dr and specialist and procedure trips just to get an antibiotic called Rifaximin that can cure certain types of IBS. Last time it took six months, a thousand dollars, four or five days off work, and a colonoscopy before I could get a prescription. But they don't prescribe enough to actually cure it. Is there a black market for this? I'm asking for a friend.
Death Stranding is Kojima unleashed, and it’s as weird as you’d expect
Bad, but slowly improving I think. I came close to committing suicide a couple of times in the last few months. After the first episode, I opened up to a close friend and family member about it. Then I decided to give therapy a shot. After the second attempt, I decided to try antidepressants. I'm on my second week of taking Lexapro 10mg and I think it's starting to make a difference.
Its copyright infringement but as usual, nothing will happen if you did copy and paste it.
> I would like to understand when the inflation happens and where it comes from. More money chasing fewer goods, sure

It comes from weakening the perceived future security of the currency, which reduces demand for it; once you monetize fiscal needs, your currency is perceived as one more at risk of being devalued to monetize fiscal needs, which itself devalues it.