skysight-inc/HackerNews huggingface dataset:
Well, with the GDUFA each genetic manufacturer has to pay the same large inspection fee regardless of how much a drug they produce and they have to pay it far ahead of the time they start selling the drug. This has driven a dramatic consolidation that's resulted in things like the recent bospirone shortage in addition to the recent sudden spike in generic prices.
> (The BBRC text is paywalled sorry)

No problem, I think this is the paper you were looking for:

https://sci-hub.tw/10.1016/j.bbrc.2015.08.109
No, because this often repeated trope simply isnt true. Government funding usually is very early in r&d, (think lots of small grants for tens of thousands of dollars which have 1 in a million chance of succes). private industry takes the outputs and spends about 2 billion dollars per sucesscul drug screening and further developing it. It is like saying a large part of web development is government funded because tc/ip came from a government lab
> hard to get a license to operate a strip club

So they are solving issue they themselves created with more laws. Heh.
Someone sent me an invite to HI5 and I assumed it was a way to pointedly tell people they should get an updated STD test, given many people called HIV "high-five" at the time.

Didn't want to confirm any personal information, and tested clear anyway, so never responded.

It was a social network?
How CNN Covers Politics
If you had to make a choice, how many social networks failed because of poor product versus poor management?
While I agree with the sentiment, that's not really what this is about. Youtube-dl does nothing for videos already taken down, nor does it help content creators.
>That's naive, totally not going to happen. I find many mainland Chinese people are proud of their country's political stance and return to the mainland proud of their allegiance to their country.

Coincidentally, the opposite of my experience.

For the record, I think you've expanded my recommendation far beyond its scope. I don't think corporations are going to solve the problem in China no matter what they try. But this is my recommendation for how corporations "that must operate in China to stay competitive" should behave. It's limited to a certain audience and it's for their sole benefit.

I most certainly think China needs to be dealt with through international measures. But I also disagree that mainlanders are as willing to support China's government as you think. And like you, that's from my own personal experience. Take it as you will.
Are they not electing to because it doesn't interest them, or are they opting out/washing out due to other factors? Have links to any studies that show one way or the other?
It's not clear that dragging an app to the trash is the "official" way to remove an app, and will remove all associated data, including whatever links it to the App Store, and causes the store to not attempt to "repair" the app by downloading it again or something.

It does seem that the "official" way to remove some App Store apps is to long-press on them in the Launchpad, and then click the "X" button that appears.

Maybe I was overthinking things, but IMO neither of these methods seem very discoverable or clear about what they actually do. Would it be that hard to put a clear "uninstall" button somewhere in the App Store? Android does this, and Windows mostly does too, AFAIK.
The more interesting thing is how this is gonna play out for high end strip clubs. Its not uncommon for dancers at those clubs to make upwards of $150k a year, which sometimes includes prostitution at the end of the night with VIP clients.
> To make an icon on the favorites bar in gnome, you have to edit a .desktop text file! Madness.

.desktop files are about the dumbest damn thing ever. Why is the 'category' of an application, which pretty much every menu interprets as its sub-folder location, determined here [0]? Why is there absolutely no ability whatsoever to set a relative path to an icon file [1]? It's like there were designed by someone who had never used a GUI before and had one described to him while writing the spec [0].

[0] Given other choices made by FreeDesktop.org, this might actually be true.
my girl left me because i listened to music all of the time, but player is amazing :))
I've been trying to make sense of 2.4.5 for a while and have come up short. So thank you for that insight.

It is frustrating working in an environment where the ASVS is held up as infallible...
It’s a really beautiful design as well, I wonder if the beauty of well designed things is because we see they are well designed or intrinsic.
In Europe I only see bicycles delivering Uber Eats and in Sweden it's even illegal to deliver with car unless you have a special permit which is expensive.
Wow 3hr video only has 1000 views. Looks great. (bookmarked for later) :)
I remember when I was maybe 10 years old my family went to Florida for Christmas. There was a cold snap and daytime highs were maybe 60F? Kind of rare.

Anyways, I wanted to swim in the unheated outdoor pool. The thermometer said it was 50F (10C).

It felt like I had been punched in the nuts after 5 seconds in the pool.

Can’t imagine what 1C feels like.
> It's all well and good to understand why this is, but if the answer is "because, on average, women prefer a different distribution of work", then we should let that be.

I haven't seen any research showing one way or the other why this is. Have any links to share?

Edit: As a side question, if they really prefer a different distribution of work, why do we as a society punish them for it by valuing that work less than we value work generally done by men?
All of the Nobel prizes were established after his death.
I’ll address your second point first because I think it’s important for framing the debate. Worldwide profits for publicly traded pharmaceutical companies adds up to $200 billion. That’s 2.7% of worldwide health spending, and 5.7% of US health spending even if you allocate all worldwide profits to the US alone.

As to your first point: what is the limiting principle to your theory? If the government can efficiently run an industry as complicated as drug development, shouldn’t it be able to efficiently run every other industry as well? If you could squeeze out Facebook’s 30% profit margins by nationalizing the web tech industry, without any adverse consequences, I fail to see why you wouldn’t do so.

The fact that prices are inelastic (and they’re often not) doesn’t get you all the way there. That tells you that the government may need to play a role in regulating prices in the extreme case. But the elasticity of price has nothing to do with the government’s competency to run a nationalized industry.

Nobody dies if Facebook imposes unreasonable impingements in privacy. But is that the dispositive fact for why the government wouldn’t be competent to run the web tech industry?
According to this that isn’t correct either, but worth noting that the Iranians started putting up build boards with the English text even if incorrectly translated originally:

https://www.washingtonpost.com/blogs/fact-checker/post/did-a...
Listen to Learn How to Raise a Seed Round
Arguably one of the hotter debated functions is assignment-as-expression through the := or walrus operator.

Quite happy with the new SyntaxWarning for identity comparison on literals and missing commas :)

Especially neat is also the `python -m asyncio` shell which allows you to run top-level awaits in your repl instead of needing to start a new event loop each time!
Oh cool, I am also an NBA fan, I also think they are one of the better player leagues. If any league can work on this it is the NBA.
My parent was saying Chrome was not compliant with the spec, but SHOULD directives are not mandatory and a User Agent may decide that it would be a worse experience for users to follow them.

Chrome is claiming that enough developers have marked fields as autocomplete=off in user-hostile ways that it shouldn't be respected, while many people here are making the case that conflicts with site-provided autocomplete and other issues push the other direction. That's how to have this discussion, not by pretending this SHOULD is a MUST.

(I don't work on Chrome and don't know any Google-internal anything about this)
You can recognize that at some point safety regulations would cause more harm in their implementation than they would be in their intended effect, right? If so, who is to say that is not already currently the case?

See https://www.forbes.com/sites/timworstall/2017/06/04/milton-f... and the video in it. It lays out how "single payer care" is only a natural conclusion if you start with a hugely distorted market.
Wonder what consequences are with diet of exclusive beef jerky coffee and beer.
I don't see any reference to Ruby in the link (or the one that this subthread was attached from). What relevance does Ruby have to this topic?
I think that was proved 18 years ago: https://en.wikipedia.org/wiki/Vebj%C3%B8rn_Sand_Da_Vinci_Pro...
Heidi Matthews's is a Canadian law professor who's done interviews with several different podcasts about all the issues with the #metoo movement. I highly recommend listening to her.

On the surface, bringing attention to sexual abuse is not bad and it is important to bring out how much of it exists. At the same time, prosecution requires evidence and it's very difficult to prove these types of crimes. Many people prominent in the metoo movement want legislative changes, which are quite worrisome.

RMS is an interesting case. He is a weird one. He's idealistic, in some cases to a fault. The guy refuses to buy AmTrak tickets because he can't buy them in cash and doesn't want to be tracked. I can admire is idealism in some ways, even thought it is a bit extreme.

He also has rubbed a number of women the wrong way, is a kinda weird dude, and has a lot of controversial political opinions. I do agree his words from the original e-mails were twisted in most of the call outs for him to be removed. It may have still been a stupid thing to say, but there is discussion and then there's like "You need to go," and the later is happening a lot right now and it's pretty distributing.

It has a chilling effect and it's going to make more people afraid to say anything. I highly recommend the book The Coddling of the American Mind, which goes into depth on this new emergent call-out culture in academia today.
Finally a college team I can get behind!
Not to be snarky, but the easiest way to get a 10x speedup is to make the previous one 10x too slow. 10x feels pretty good until you find out it was really 40x too slow. I say this only because getting 100x improvements on naive designs has led me to be suspicious of 10x improvements. The principle is that where 10x was available, more is there.

The writeup doesn't mention design choices in Grand Central Dispatch. Is that because we have moved on from GCT, or because it's not known?
Monads don't have much to do with it, but the GHC runtime uses fibers for concurrency, no?
The implication in the article is that the travel schedule/lack of sleep is the central issue, not the intensity of the workout.
But how do you know the ideas were/are great? Rejection isn't evidence of quality.
> if you sleep with any of our customers for money[1], we'll 'fine' you $2000

This sounds like a refreshingly constrained non poaching clause. It is quite common for independent contractors to be forbidden from establishing a direct bussiness relationship with the customer's customers.
> That is a lot of why I'd be okay if the thing had a vote before the full house

A vote before the full House is literally part of the process for submitting articles of impeachment to the Senate.
What Earth would look like if it rotated backwards
> The policy is about recommending polite speech

The policy is not about "recommending" anything, it's about "requiring". That's the essence of most of the negative reaction. There are plenty of things that I will usually be happy to do voluntarily but will strongly oppose being required to do.
If you had precise eyes and memory to clone a museum paint at your home would be a steal? The right of one to offer something to be sold is the same meaning of the right of another one to see the offer and "build"(clone) by oneself. If one have the right to choose not to buy something good even if has the money to. Money can't be tracked to ownership information, it's just a product to trade for anything. Ownership is a past state, not forecastable state, just like real time only goes forward.
I think you're missing the point. Trading and Sales used to be people intensive, in today's parlance, 'high touch.' You had people talking deals on the phone, you had transactions sent to the exchange where a floor trader did the execution, you had a trader's assistant fill out the trade ticket and submit it manually to the mid-office, where you had a person who recorded the transaction then passed it to the back office, where yet more people processed and settled the trade.

All of those people are gone. No need, we have automated much of this deal cycle. Your best example is to take a trip to your local exchange floor, which used to be littered with runners, assistants, floor traders, etc. It's eerily quiet these days, as most trades are executed by computers.
I'd say it might be more educational if they are on C64 machines.
Strip clubs might be exploiting dancers, but I don't see much evidence that they're exploiting them financially. Have you seen the cash they bring home?

Source: There's no way I'm telling
`$` is a built-in wrapper around `document.querySelector` in many popular browser consoles (along with `$$` for `document.querySelectorAll`).

Though of course if Safeway's website does have a global `$` from jquery then that would take precedence.
anyone remember plurk? it was amazing, tweets in a horizontal timeline view with you peers and click to dropdown comment thread
To play devil's advocate, part of the reason that this business model survives is because of how much better it is for the creator of the service.

Receiving a steady flow of income from those who use your product every month is a great proposition. Additionally, if you build a product useful to more people, your monthly income increases (it's recurring, as opposed to being cash-flow based).

On the user's side, the argument is twofold:

(1) there's increased competition. Economically, the switching cost is lower if you're paying each month— to make an analogy, it's easier to convince someone to lease a new car at the end of a lease than it is to convince someone to buy a new car when they have already bought a car. This allows a lot of new and impressive SaaS companies to grow like wildfire.

(2) there's more freedom of choice, because you're entering a relationship with a company only for a period in which it benefits you enough that you want to continue using it (and as mentioned above, there's ideally plenty of alternatives). This motivates companies to improve their offerings.

While it isn't perfect, I doubt amazing apps like Notion would exist if not for a subscription model. It just isn't worth it to make a perfect note-taking app otherwise.
True, but I meant in more general terms- I'm not sure that we've got a good handle on when to expect any particular level (or achievement), other than the very short term.

It seems like even Tesla themselves have Trouble forecasting more than +/- 6 months out.

Predicting technological progress is hard, both in terms of timing and absolute ability. And this is before you even get into predicting the market success of a shippable product.
Python 3.8.0 is now available
I assume you are better then a drunk teen that comes from a party and has 3 months of experience, The most road deaths that happen here in Romania are caused by young drivers cumming from parties late at night, maybe drunk, the car is full with people so you have 1 crash causing a lot of deaths, So the average driver from the stats is a terrible driver because the stats are skewed hard by the inexperienced, drunk or tired drivers. You can have both this next two facts true at the same time

1 replacing all drivers with AI is x% safer

2 replacing you an experienced responsible driver with an AI is less safer

Does it make sense ?
Totally agree. With GitLab you can do static and dynamic code analysis, as well as dependency and container scanning on your PR/MR out of the box.

And your security team gets an organization wide overview of the security results as well https://docs.gitlab.com/ee/user/application_security/securit...
I know rust is not C or C++, but we are not programming in x86 assembly, but for the language "abstract machine". And if the compiler infer that this memory location is not used by other threads because we don't use an atomic operation, it can perform optimizations that could result in subtle bugs. That's what undefined behaviour is.

Although in this case, I guess this is probably fine since the non-atomic read can't race with a write.
> It does seem similar. If you don't want to see the ads, don't use the service.

That just doesn't make sense. Not using their services has zero advantages compared to blocking ads. But by using them, you raise their costs, making their business model less viable.

> I don't use an ad blocker, and if I don't want to see ads I pay for the service, such as with Reddit, Ars Technica, Windows Live Mail, Netflix, and YouTube.

By paying for services, you show that you have disposable income. You cannot escape ads that way except in the short term.
It doesn’t. It’s a written-only solution. If you listen to a speech from someone who uses the latinx you will notice they don’t even try to speak it, and they just go with the “latino and latina”.
In related news, PyPy now appears to consider their Python 3.6 interpreter released, if I'm understanding this correctly: https://morepypy.blogspot.com/

While I'm happy this work is being done, waiting over a year from a 3.x release for an ~4x speedup from PyPy is kind of a bummer. Most of my work is already on 3.7.
And right after that Gosling describes how he did much the same thing with Wirth's pascal compiler! He thinks that's OK because there was no copyright notice attached.
This is the consequence of monopolies. Before YouTube gobbled up the world there were great, niche video sites ran by fans of the coolest things. They are mostly gone now. It is sad. The web really used to be an adventure. I miss that part of the internet. You felt like you found these secret underground worlds where people were really into something. Now it’s different. Maybe what we have now it what is needed for content creators to be fairly compensated, but I will still miss it.
cool idea. but..

1) https://en.wikipedia.org/wiki/Cat_(Unix)#Useless_use_of_cat

2) speaking of #1, wheres < > &| etc?

3) Question #2:

Extract only Ken Thompson and Dennis Ritchie's last names. Hint: look at Thompson and Ritchie's names in the list. What's special about the position of these lines in the file? Can you find a command that lets you get just those lines?

um:

egrep '(Thompson|Ritchie)' file

there is more than one way to skin a cat, and some of these don't require static/fixed field numbers. and even then: `sed -ne 3,4p`. wheres that?
Ok but even if I, hypothetically, conceded that point, all it would take to make my point is 1 piece of hardware or software that didn't work as intended. Wacom tablets, for example, do not have drivers that can be installed from Wacom. Yes, there is an Open Source project for those but most users wouldn't know or have the technical capability to install that past what's been contributed to the kernel.

For technical users, Linux is fine but it still needs some tinkering. Technical users are more comfortable with tinkering so it's probably not a big deal and "just works" for them but that's a very liberal definition of "just works", imo.
Stability, in a technical sense, means if you push something off of equilibrium, it will return to equilibrium after some time has passed. It is unstable if it does not return to equilibrium. Less stable means it takes longer to return to equilibrium, more unstable means it diverges quicker from equilibrium.

My understanding of dutch roll is it takes only a small perturbation to push it off of equilibrium and into oscillation, the oscillation is sickening to people, and it doesn't return to equilibrium without active correction (by the pilot or an active system). A small perturbation means it happens more or less continuously. Correcting the oscillation rather than making it catastrophically worse is something only a well trained pilot can do successfully.

The stable point is not straight and level, it's lurching around sickeningly. I mean that literally, at Boeing I was told about a 707 crossing the Atlantic when the yaw damper failed. The pilot didn't crash it, but the airplane was full of vomit by the time it arrived.

To be technical, it is not stable flying straight and level. The stability point is dutch roll, like a carbureted car does when the engine rpm "hunts" at idle.
US nuclear bombs at Turkish airbase complicate rift over Syria invasion
Newman: Apostle of Fear and Trembling to Liberal Christianity
My point is not that safety needs to be increased to the maximum. It's assumed the current level of safety takes into consideration existing market signals and the economic trade-off of diminishing returns.

My point is that trading safety simply to solve the barrier to entry problem has a dangerous cost/benefit trade-off, especially when it is not the only way to solve the problem.
Road to the Oasis Mainnet
Yea I wished it were easier to use out of the box too. The code is fortunately very well organized so you can just copy the pieces you need: https://github.com/GoogleChromeLabs/squoosh/tree/master/src/...

It also does make sense for you to pick and choose only the compression codecs you will need. Otherwise the cost of making every client download huge and unused wasm libraries might outweigh any bandwidth savings from compression.
I use Confluence for various topics in my PKB. I have sections (spaces) for Recipes I've found or made, Technical internals (network map and connectivity, what did I do to make that Raspberry pi project?, How do I add a new VLAN to this damn router, What's the process for restoring my paperless document server, one off scripts / oneliners I find useful, etc), meat space stuff (hardware/powertools/appliance serial numbers, part numbers, maint schedule, where to buy parts), and my own tracking of college course syllabus (or cert exams) for studying and tracking. Adding my own notes and processes with sources that I obtained the information has been great.

Setting up the PKB has been one of the most useful projects I have; now if I can just remember to keep it updated often!
Citation needed.

Let's look at the scale. A brain neuron is 4 microns to 100 microns in size. Whereas a transistor sizes are now pushing 3nm. That's a lot of free space to work with, why can't we easily simulate many neurons within the space of a biological neuron?
> China is not turning out to be a land of milk and honey for western corporations. The best business decision for a Western business with regard to China may be to give up on it, because the PRC wants your local competitor to succeed, not you.

Agreed. Which is why my advice is limited to companies who will lose to competitors if they fail to compete in Chinese markets. Any company seeking to strike out in China without a local competitor will fail because of the reasons mentioned in the article. That said, any western company trying to compete with Chinese companies will also fail.
Maybe when it was all empty land. Right now the current density is what determines what transportation is viable, or can even be built. Even acquiring the land would be incredibly difficult with our politics and economics.