skysight-inc/HackerNews huggingface dataset:
Extensive studies on the thermodynamics of DNA helix formation have long shown that there's a very important contribution for base stacking [1]. This isn't news. What is new in this study is that they explore how hydrophobic interactions could play a role in DNA binding interactions with proteins by varying the solvent hydrophobicity. The title and linked article are quite misleading, the paper itself is making very different claims [2].

[1] https://academic.oup.com/nar/article/36/suppl_2/W163/2505801

[2] https://www.pnas.org/content/116/35/17169
> When we add up all these figures we come to a total of $13.16 per day, which clearly can’t keep The Pirate Bay afloat.

I ain't so sure of that. That'd be enough to pay off the monthly bill for a small VPS every day or so (so 15-30 VMs - or one or two giant ones - would fit in a monthly budget), or to cover the power, networking, and other colocation expenses for physical servers. TPB is a popular site, but the computational load should be minimal; the only thing TPB hosts is the metadata for the torrents (whether in the form of a small downloadable file or a magnet link); a rack of older servers (5-10 years old) should be able to handle that mostly-static load.

Banking on the idea of Bitcoin et. al. getting more valuable is probable, though.
The "Pro" suffix completely lost its value with the iPhone 11 Pro Max.
There is this theory https://en.wikipedia.org/wiki/Classic_Maya_collapse#Systemic... as well as this theory https://en.wikipedia.org/wiki/Late_Bronze_Age_collapse#Envir...

Societies have collapsed before, and it's likely to happen again. Climate change looks like an extremely good trigger for such an event. It's unclear whether we would be able to recover, or how long it would take.
Car owners are a class of people that ranges from people living in said cars to the the hyper rich.

It's probable that Bezos has to give zero fucks beyond what brand he prefers. People living in their car are probably just praying it doesn't break down. In between there is a giant middle ground that composes 80% of the car owning population whose benefit derived from car know how is inversely proportional to their wealth.

Most car owners should learn the basics of how their car works and how it is maintained even if they intend to outsource that labor to others just so they aren't trivially taken advantage of. If we assume that MOST people aren't born into wealth most people could stand to learn the basics during the time when they have more time than money and then they could make productive use of this know how later.

I'm not sure how you can even argue this point.
I get that there is a legal and constitutional distinction between citizens and non-citizens, but the idea that a non-citizen is (ethically) less entitled to basic human rights simply because they're not "one of us" is just disgusting to me.
Graphing calculators weren't part of any math classes I took, but my first experience with programming was TI-BASIC on a used TI-86. Programming a PC wasn't really an option, but the small calculator felt personal and a lot less intimidating. It had an obvious place to start from and included all the software you needed! Of course I mostly used it to play games other people wrote, so much that I eventually had to get an 89 for the better TI-BASIC, TIGCC and all the software people made with it. I wish I learned about the GP32 sooner.
False. If you cross the border illegally you are a criminal, period. It is not suddenly legal if you subsequently request asylum and asylum may only be granted if entering at a legal port of entry, so these people do not qualify for asylum.
I don't get why people play devil's advocate in defense of scummy behavior by tech companies. Every shitty thing they do should be called out, exposed and condemned. If they know they don't have public support or defenders they will be better behaved.
The second actually involves the first, and this is the point we lose.

If we could have runaway climate change somehow not disrupt global economy, we could eventually tech our way out of it. But the game over point is when the economy stops, and humanity no longer has capability to slow down and mitigate the effects of warming. At that point there isn't much left of humanity anyway.
I personally used Chef, Salt and Ansible, Ansible was the easiest to start with, but also the least dependable one, and didn't deliver on one thing it supposed to - reproducibility.

On the same image it sometimes succeeded and sometimes failed. This was happening on Amazon Linux 2, and basically once in a while yum database got corrupted. I'm suspecting there was a conflict between yum run by Amazon Linux 2 on boot, and ansible didn't respect locks acquired by yum?
As is often the case, it's important to distinguish absolute value (the total net positive or negative created by, say, CBP or law enforcement in general) from marginal value (the additional net positive or negative created when you increase their funding).

It's possible and rational to believe that agencies like CBP are (or would be at some level of funding) a net positive in absolute terms, while also believing that they're a net negative at the margin. This is approximately equivalent to the belief that these agencies should exist but should be smaller than they are today.

Eliminating service contracts won't "bankrupt" CBP and prevent it from getting anything done, but it will reduce the amount that it can do at the margin. For anyone who believes that CBP funding is a net negative at the margin, including those who believe it's a net positive in absolute terms, this is a desirable outcome.
Your "tldr" is roughly 100 words, same as the rest of your comment.
Aren't all Apple A series CPUs made by TSMC in Taiwan?
Note-Taking Strategy 2019
> > LED lighting fixtures, a kind of used in horticulture, containing over 5,000 LEDs spread across 6 light bars

Also, really makes one wonder if that sort of specific setup is perhaps the subject of an existing patent.

Imagine being in a position whereby there can be no innovation beyond a specific exclusion on a competitive cost basis, and that exclusion being wholly owned already.

Seems an alarming way to either enrich incumbents, or stifle Innovation full stop, or both.
Cars?
> The DOJ antitrust people and the FTC got a lot of their teeth knocked out when they went after Microsoft in the 1990s.

How do you mean? Microsoft got throughly declawed in the 90s, and never regained their top predator status.
The military and homeland security.

Also: A half reasonable single-payer health care system should save a lot of money over-all. The fiscal conservatives should be all over that one.
For the end user there is something to install - specifically, Docker, which is quite... hefty on Windows
But won't somebody think of the poor businesses who'll surely be driven to ruin if they can't track my every step?

These people keep shitting in the well, and yelling at us for buying bottled water.
I have completely given up on apple. I think the products are horrible. However, I will purchase any computers which I can assembled in berry compliant countries. Double points for the USA, apple just earned 10k from me.
That's happening already as manufacturing countries ignore copyrights from the source country.
The U.S. balance of goods and services trade is one component of a complex economy. Of course it matters, but the simple balance does not imply that it's a bad thing, or that it will harm the U.S. economy in the short term or long run.

> Yes, but I do not have a trade deficit on the whole as well.

Presumably you mean that you add net value to your wealth each year, despite having a "trade deficit" on most economic relationships. Well, so does the U.S. The net change in the national income is called GDP growth and it is mostly positive in spite of the negative balance of trade.

Why? Because the U.S. economy is primarily internally driven; trade is only about 15% of GDP. So more important than the balance of trade is how that trade impacts the domestic economy.

Would we experience even more economic growth if we had a positive balance of trade? Maybe. If we kept imports the same and grew exports, that would be great, but that will either happen or not based on private industry. The government does not have a magic lever to create new exportable goods and services.

But the government does have a variety of levers to reduce imports, some of which it is pulling right now. To predict the economic effects, it's not enough to just look at the balance. You would need to untangle the domestic effects of reducing imports that may be inputs to domestic economic growth. It's certainly possible to use trade restrictions to create a positive balance of trade, and create negative GDP growth at the same time.
I just think that you're focusing on the wrong things here. Towards the top of the article they say:

> One of the difficult tasks was to schedule a meeting room in a scheduling application, using information contained in several email messages. This was difficult because the problem statement was implicit and involved multiple steps and multiple constraints. It would have been much easier to solve the explicitly stated problem of booking room A for Wednesday at 3pm, but having to determine the ultimate need based on piecing together many pieces of info from across separate applications made this a difficult job for many users.

This task isn't overly complicated. It's a task that computer-savvy people do on a regular basis, but it complex enough that it might trip up someone who can't use a computer well.
Hackintoshes are great but I would never rely on one for any kind of production work if my business depended on it. I had a Hackintosh tower that went completely dead after something happened with device IDs. The machine was unusable. I had system updates disabled too so I'm not even sure what happened. Had to reinstall the OS and Clover (or whatever the loader was at the time).
My life? Not at all. I don't really use the product except for managing event invites. But I don't run a business that generates most of their leads through Facebook. Nor do I organize any volunteering or community events that would benefit from reaching a large amount of people.

This is a strange hill to die on, because I really don't agree with most of the company's actions. Yet every time I'm outside of the U.S, I see how important Facebook is to a lot of communities. I could be wrong, but I've just seen large social graphs like Facebook's create value. Hence my surprise to the author insinuating it's made the world a worse place.

Ironically enough the people that benefit the most from the product aren't the primary source of income, as I'm sure first world users are valued higher per ad dollar.
Have you read about Trump's tax cut?
This seems like poor form coming from a competitor.
"Certainly the interconnectedness in general is moving us forward."

It is undeniably moving us. I can't imagine the argument that it's not moving us. But I'd submit unless you mean "forward" in the trivial temporal sense, I am unconvinced it's "forward" in the general sense.

I blame as the root cause the mismatch of incentives between Facebook making money via advertising vs. the user's desires and goals. Advertising gives Facebook billions of dollars worth of incentives to invade privacy, hook people to ways of giving up their personal info, manipulating them in ways to ever up "engagement" with the ads specifically (not just the service in general). That's a big negative in my book, possibly as large as "break the political system" large.

On the positive side, we can't credit Facebook with everything thats happens on their service. At best they get the difference of the good social interactions that happen today minus the ones that were already happening without them (and can still happen without them), e.g., school and family reunions and parties happened before Facebook.

Until we do something to remove these incentives created as a second-order effect of trying to build services on top of advertising alone, anything is going to be toxic, whether or not it's called "Facebook".

The Internet is now primarily a tool for serving eyeballs to advertisers at any and all costs, rather than a tool for serving people. How can any other outcome occur until that is fixed?
Get used to it, kids. Wait until you see the price tags on those required college textbooks.
That doesn't fly, because you could dismiss your posts in this comments section the same way: you're pro-car and anything that makes driving less convenient is a bad thing no matter what.

It's not very productive discourse to make these claims about others.
It depends on your definition of "best bang for your buck".

Social Security doesn't exist to maximize returns, it exists to protect the elderly from extreme poverty once they are no longer able to work. Because of that, the funds are invested in a very risk averse manner.

I'd certainly be open to the idea of a US sovereign wealth fund in some sense, but I don't think privatization or anything else where individuals are making decisions about their own Social Security account is a good idea, since we'll have to create another Social Security-like program to support the people who invested poorly and are unable to support themselves.
Use Mind-Hangers to Teach Concepts Better
What is bc?
>Theres actually news here otherwise Apple wouldn't have published a press release

I am not sure about that.
>it appears that the payload is relatively large

Not knowing much about Blazor, what are you referring to here? The size of the WASM blob for your own code, or does Blazor have an associated runtime that's large? And what is considered "large"?
Seems rational to me. What's the implicit illogic?
I've had a dish of lemon grass stir-fried cricket. It was at a restaurant that served lots of bug based dishes. It was one of the few that we had that I'd regularly order.

They didn't taste like shrimp though. They also have a lot of chitin.
Morphing Materials: From Programmable to Learning Matter
That is a very valid point. Even the best city I've lived in as far as public transit goes had issues such as stopping service around midnight, even on weekends. If the goal was to reduce drinking driving and/or driving tired you'd think they'd keep those going, but instead they just bring out the DUI checkpoints.
Well, people do maintain obsolete forms of communication because they can & or have specific circumstances requiring them. Thats why I am skeptical others would completely abandon a communication technology - there would still be the Globulon Technical museum hosting anual morse code transmision relay with steam powered spark gap transmitters between specially selected nodes in the local dyson swarm.
Don't try to start with a web app. I'd recommend looking into Fable (the F# to js compiler). Write f# and run it in the browser, I found it to be a better and faster feedback loop when compared to a .net project.

Play around with the f# language (don't touch the js inter-op) until you can figure out if you actually like f#. Take it slow, it's not just a new language, it's a different paradigm. If you get frustrated, take a break for a few days, watch some f# videos and let the knowledge settle. You'll eventually start having evrika moments.

Look into other functional languages. Maybe you'll like others more. Accumulate knowledge and experience until you start thinking "I could do this a lot simpler in f# (or other lang)".

Then, if you want to use f# in a c# project you just need to learn how to reference a project in another project.

If you want some resources:
https://fsharpforfunandprofit.com/video/ some of these videos can get you "hyped up" for functional languages

https://www.youtube.com/watch?v=4YO4XmtPFQw

https://www.youtube.com/watch?v=EPfpO_6uFAA

the entire https://fsharpforfunandprofit.com/ site is a good resource to learn everything from the basics to the wizard level stuff.

As an editor you can use Visual Studio but I'd recommend Visual Studio Code with the Ionide extension.
I very rarely look to friends and family for career advice. I typically seek developers who have something interesting to say about the topic and are passionate about sharing their insights.

When I was in college I read The Passionate Programmer by Chad Fowler, which was my first exposure to the concept of treating yourself as business even when working for an employer.

Later on a found Patrick Mckenzie's blog, via his blog post on salary negotiation.
https://www.kalzumeus.com/2012/01/23/salary-negotiation/
Which lead me to discovering a bunch of other great posts.

I could go on, but the moral is to seek out successful people that are willing to share their story.
1. You don't want to reimplement a quarter of the network stack in userspace.

2. Network infrastructure may drop "unusual" packets.
Show HN: Node.js functions for 🇮🇪 Irish public transport real time data
Nicotine as a Cognitive Enhancer (2014)
In prison, only non-programmable calculators were allowed. A friend somehow had gotten a TI-85 in. I programmed it to say "NON-PROGRAMMABLE CALCULATOR" as its startup message, so they wouldn't take it during a random search.

I also wrote a basic stock portfolio manager - this was the only chance I had to program during my 5 years there.
It’s a pretty obvious genetic adaptation to dealing with varying levels of sunlight. You even see it in the Americas which (presumably) is based off a relatively recent, smallish founder population
Anti climate change website

From the last paragraph:

"Do not forget that the Global Warming Petition of 2007 project, 31,487 scientists (more than 9,000 of whom have PhDs) have signed the following statement: ""There is no scientific evidence that human release of carbon dioxide, methane or other gases is causing, or in the near future, ...""

https://www.snopes.com/fact-check/30000-scientists-reject-cl... reports

"The petition was created by individuals and groups with political motivations, was distributed using misleading tactics, is presented with almost no accountability regarding the authenticity of its signatures, and asks only that you have received an undergraduate degree in any science to sign."
>the solution is

I'm sorry are you a politician or an authority figure?

>1

How did you measure the optimal number to be 1? And how would you value an ethnic minority to be just as valuable as the majority? Don't you support greater minority birth rates at the expense of the majority?

>explanations

No, that's philosophy. Granted, I haven't encountered a reproducible study on climate change, the scientific method proves or disproves hypotheses to provide a baseline of knowledge. The scientific method is how scientists develop early-stage solutions to climate change, not building contraptions.
this website is very sensitive on scroll event!
No, that doesn't really make sense. Note in your example of cancer that pain killers are in fact given to cancer patients, they're one of the biggest users of our strongest pain killers. But nobody claims painkillers treat the cancer. So how could we claim pain killers treat other illnesses such as fibromyalgia?

Chemotherapy is a treatment that targets the actual cause of the pain (the cancer) and (hopefully) kills it, leading to remission and (hopefully) return to normal function of the person as a cancer free individual.

A pain killer is something that does not target the cause of pain, does not treat or reverse or cause remission for that cause, and does not cause the individual to be illness free.

It just makes the person feel less pain, so they can be more comfortable.
Erasing mistakes: California helps inmates remove tattoos
An interesting counterexample is the many private trackers that do just fine off of crypto donations. Without naming names I'm personally aware (as in, I can go look at the donation status pages) of at least four that rake in $500+/mo with a small fraction of TPB's usercount.

I think this says more about the type of user who hits up TPB vs. the type of user who has accounts on private trackers - it's probably a reasonable generalization to say that a member of a private tracker has a higher level of tech sophistication, including with cryptocurrencies, than the average TPB visitor. Heck, my boomer relatives use TPB on occasion. Interactions with TPB are also a lot more ephemeral and anonymous - private trackers can give donators a cupcake forum icon or whatever whereas I'm sure 99+% of TPB visitors have never made an account and probably aren't even regular visitors. Similarly, users of private trackers are likely on average significantly more invested in the continued success of the site and therefore more willing to cough up, in contrast to many TPB visitors who probably ended up there via a general search and wouldn't really notice if they were grabbing a torrent from any of the other big public trackers.

So, I think it's fair to say that expectations for certain types of sites - ones that have a low/no barrier to entry, are functionally replaceable units, serve less technically-inclined users, and have a rep for legal sketchiness - need readjusting. Others, especially ones that provide persistent, difficult-to-replace value for users, seem to do ok.
I used to be a math teacher, but somehow I don't know what the use of a graphing calculator is. Why do students need them compared to a basic scientific calculator? In one school system I taught in, you didn't even need any calculator at all for physics because we graded them entirely on their working and explanation. They didn't need to produce numerical answers. A calculus course I taught effectively didn't need calculators either, although they were allowed, but pretty much no use.
Yeah, it is an incredibly terrible story. Sometimes in fiction (books, movies, etc) I think how unrealistic some depictions of cruelty can be, but then I read stories like this and remember that fiction rarely captures the actual levels of cruelty people are capable of.
I started using an HP-48G too in the last year of primary school. When my secondary school forbade graphical calculators, I switched to a HP-15C that my dad had bought for his PhD in the early 80s. Fellow students used to make fun of RPN, a calculator without = sign was mindblowing for them.

I finished the university entrance math test in 12 min. This was mid 2000s. Lots of nasty calculations. Graphical calculators were banned too. They naively thought non-graphical calculators can't do numerical linear algebra or analysis. But a 15C is one of a kind. Second hand units are still crazy expensive.
Aromizadores
Gonna respond with this separate post, since OP edited their post to respond to mine.

>Untrue. The act of pulling is itself is a complex maneuver that practically invites accidents. Most accidents occur at low speed, and often, when you pull over, you pull over into an area where pedestrians are active. It might be the case that pulling over instead of using a phone at a red light results in more people being injured or killed.

As I've said before, driving is always an inherently dangerous act, and I'm not disputing that point. It seems to me as though you don't believe risks should be mitigated; that you're saying, "Well, pulling over could be pretty dangerous, so I think you should still be allowed to distract yourself with your phone while driving". Is that correct?

Driving in an area with a lot of pedestrians is certainly dangerous, but to my point, it's far more dangerous if the driver is staring at their phone rather than consciously looking for people walking around in an effort to avoid them.

>Anecdotal personal misfortune is not an argument for society-wide policy.

Again - how is not getting into an accident "not a rational cost-benefit tradeoff"? Can you provide any sort of valid argument in support of taking your eyes off of the road? Do you have any kind of data that shows that not looking at the road is safer, or for that matter safe at all?