skysight-inc/HackerNews huggingface dataset:
This. This is one of the most commonly misunderstood aspects of medicine today.

As a society, we have become exceptionally good at treating pathological diseases. This is how we know we will eventually cure AIDS because we fundamentally know how to do this kind of medicine. (And it appears like an AIDS vaccine, and perhaps even a cure is closer than we think.)

Unfortunately we are terrible at treating any aging-related disease. Diseases such as those that relate to the fundamental breakdown of the metabolic process, cancer or Alzheimer's. We just simply don't have the research and experience to treat these diseases in anything less than a crude way.

For those unaware, Chemotherapy and Radiation are probably some of the least-precise medical treatments we apply on any broad scale today in modern medicine. We try to radiate or kill your cancer cells before we kill the rest of your body. Seriously.

Anyways, more research on aging-related disease is critical if we want people to keep living longer. If we don't, then we should just focus on pain management and let people die as they grow older.
I use Octave everyday for my business and I absolutely love it. I have a background in Matlab (and I still have a student version someplace) but turned to Scilab and then Octave to do audio signal processing. It's a fantastic package and you can't beat the price, but if you want to use it as a Matlab alternative there are couple of gotcha's that I ran into:

- the plotting using gnuplot is not as flexible as Matlab's plotting, although it is getting there

- in an attempt to steer clear of copyright issues (I presume) many (most? all?) of the mathematical functions have been written from scratch, and while they typically use the same references as Matlab functions, Octave functions may give slightly different answers than their Matlab counterparts. If you need 100% compatablity with Matlab, make sure to do plenty of testing first.
What Does A Business Co-Founder Do?
I assume it's about running the ducts in the room rather than in the walls so that the cold air cools the room as it travels through the ducts and not just when it exits the vents?
I don't know but the bus driver probably earns less than most of the people riding the bus
hmm, I'm pretty sure that's what Octav had told me in chat.. either way you require an email address...

RuntimeError: The request is invalid: {"message": "invalid JSON message", "errors": [["", "A valid email address is mandatory"]]}
Lots of great products are made by teams of only developers and designers all the time.

I think the real question is why do such low quality products get produced by business when building LOB apps to solve "real" customer problems. In my opinion it is too much interference in the communication chain between the customer and the devs designers and that is usually a management problem.
> Transplant itself is really hard on the body and then
> you take anti-rejection drugs for the rest of your life.

It would be nice to have genetics research advance to the point where we're able to grow our own organ replacements. Elsewhere in the comments people have suggested donating to cancer research. An alternative I would humbly suggest is donating to organizations that participate in stem cell or other genetic research.

If conquering cancer is a while off, replacing someone's cancerous organs with healthy new organs that exactly match their own DNA is a good way to save more people as cancer research is ongoing. It also has myriad benefits beyond just cancer such as helping amputees, burn victims, and so on.
A way to have a real time conversation with someone on the internet? What a novel concept. I guess IRC and the litany of instant messaging protocols didn't fit the need here. Hooray for re-inventing the wheel.
I didn't see the Beatbox button first and thought she now sings the letters, like http://translate.google.com/#de|en|pvpvpvpvpvpvpvv%0A

Other languages yield interesting sounds too http://translate.google.com/#de|es|pvpvpvpvbvbvbvbvpvpvpvpva...
That does help. My dad was in the army and was stationed in Korea for a few years. One weekend he was eating lunch with some Koreans he would be working with. Well, near the end of the meal he was offered some burnt rice. He graciously accepted it and ate it. After the meal his translator informed him that burnt rice was considered a delicacy in Korea. Furthermore his predecessor had been offered the same dish and refused. His predecessor lost a lot of respect by that decision
Using DLP to Protect Your Source Code
If the pavement were white, I'd never be able to see anything. Bright reflections = low visibility.
Great Products Are Not Just the Product Guy's Job
I don't know if anyone else has noticed this, but - as interested as I genuinely am in learning to fly one day, why is it that so many flying-related articles tend to crop up on HN over the months?
The word "sexism" is too often used without any discussion of its definition. Here are a few definitions for "sexism" from Google:

I. discriminatory or abusive behavior towards members of the opposite sex
II. prejudice or discrimination based on sex; especially: discrimination against women
III. attitudes or behavior based on traditional stereotypes of sexual roles
IV. Attitudes, conditions, or behaviors that promote stereotyping of social roles based on gender.

The sexist remark in II is quite common. In some dictionaries the word "sexism" is itself defined in sexist terms: "sexist - a man with a chauvinistic belief in the inferiority of women". It may be warranted by the attitude's prevalence; it is sexist nonetheless because it promotes stereotyping.

Definition IV is probably the most enlightening of the bunch. One valid yet unpopular answer to the question "why so few female software engineers" is that most parents provide a sexist (IV) upbringing. Given the standard attitudes (gender identification), conditions (girl's toy collection), and behaviors (mom's occupation), the odds are stacked against a female becoming a software engineer even before she enters the first grade. These things change but it takes generations.

Inspecting my own behavior as a male software engineer, I would find myself guilty of several of the attitudes and behaviors mentioned in the article. My first hope is that I do not discriminate by gender (I'm a jerk to men and women equally) and my second hope is that I can be less of a jerk to everyone.
Well, seeing how Apple shares fell about 6-7% where they are traded today and this has been the only major announcement recently, I would say that yes, to a degree Apple stock prices are determined by whether Steve Jobs is undergoing medical treatment.

Whether this is a good thing is a separate issue.
works on arch linux with chromium 8.0.552.237
I went here last year (the article's title confused me; didn't realize it didn't have regular hours until now) and was extremely impressed by the collection.

Plenty of enormous machines to marvel at, and plenty of smaller examples I once used to have at home or work that I got all nostalgic about.

Definitely a cool place to check out if you're visiting the area.
New paper finds super-exponentially accelerating CO2 growth
Why Writing For The Atlantic Is Easier Than You Think

I expected there to be some sort of rigorous process--a waiting period? a physical? some paperwork?--before I'd be allowed to publish an essay to hundreds of thousands of readers. But here's what happened instead: On a whim, I called a friend of mine who's a columnist for his local alt-weekly and set up an appointment for a $79, 45-minute lesson. Two weeks later I picked a mildly unusual experience of mine and gave a brief, rushed overview of it, remaining about as deep as a kiddie pool throughout.

Thanks to my friend, I knew the secret to writing modern middlebrow pop-culture essays -- just draw some arbitrary connection between your topic and another topic that seems, at first, to be totally unrelated. Unfortunately, I ran out of time before my deadline, and I never really found an interesting connection. But it's hard to complain when you're playing in the clouds.
Entrepreneurs Corner: 10 Health Issues of Founders
Heh - this Brit didn't notice the possible alternative use at all. I thought the domain was slightly Japanese-English style - cute and quirky.
That's a very US centric view of things.

It's funny my original comment must have been modded down several times and then modded back up again, it's almost as though there is some misinterpretation going on there.

If you disagree with it feel free to speak out :)

The idea behind it is a simple one: If rich people can use their money to 'jump the line' and buy the organs of poorer people that have died but left with a donor-codicil in their name then it would be good to limit the distribution of those organs to people that are roughly in the same income bracket.

By doing that there would be a drive for people that are wealthy to encourage research that would relieve the need for donor organs or there would be a push to reduce the income disparity so there would be more people available in the higher income brackets that could serve as donors.

Both would be beneficial in the long run. Having the rich be overrepresented as the consumers of donated organs and under represented as the donors (in absolute terms) is not good for society at all.
It's a common error among some programmers.
The Keys to 10G Network Analysis
Ask HN: Please Review My First Attempt at a WordPress Theme Design
Hey everyone, long time lurker here. Here's some background. I'm a Philly based guy who recently decided to wind things down with my first real startup, http://greenkonnect.com/. I was primarily handling the business side and handling the product (but not really the design). Now in my downtime figuring stuff out, I decided it was time to move beyond just business guy and expand into being a business/design/usability/front-end guy. I love being a product concept guy, but I want to be able to do the concept and design.

My first project in this process is the creation of a WordPress theme for a blog that I write with a friend, http://lessdoing.com/, which we're moving away from Posterous.

I'd love feedback on this theme concept: http://cl.ly/3p421X0H3i1N0D083b3a. My goal with it was to put a focus on the content and let everything else kind of sink into the background.
Tech startups overwhelmingly focus on male or gender neutral problems. In sectors where female spending dominates there are far fewer startups, and that is a problem.
Looks great and I liked it, but the late notice on the 140 character limit is annoying.

I had to type out a list of projects for my week of vacation, so start typing away, click Create, then doh! 140 limit? Select all, cut, open Stickies, new sticky, paste, quit.

Would be great if larger stickies could be created. Or if you are going to have a 140 limit, have a character counter there somewhere.
It's a different matter in a job posting; in that case, it's a synthetic PR move, where the posters think they are showing how hip and cool their company is. Usually also a sign of unrealistic expectations.
Tips for Proper Application Logging
Nice work! Do you plan to make money from this? As you said, it is a very crowded market and I would suggest you to be ready for a long PR campaign. Peldi from balsamiq has great advice: http://blogs.balsamiq.com/product/2008/08/05/startup-marketi...

If you choose the freemium route, you could give away to bloggers and alike, free premium accounts for them and for their readers. It is a great promotion tactic.
Ask HN: Anyone heard back from Angelpad after 2nd round?
We got through 1st round, submitted app for the 2nd round but never heard back from them afterwards. Anyone else in the same boat?
He really has no such obligation. Do you have any idea how many things a CEO knows that might negatively impact the share price of an organisation?

He has the obligation to release certain specific information mandated by the SEC in a timely manner (details of his health are not on the list - it's largely financial) and there are certain things a company can not say (which basically boils down to honesty).

The SEC also say he and the company have to communicate in a particular way when information is shared (for instance so it's available to the whole market - no selective disclosure, and again it has to be honest and truthful and so on) and projections are heavily caveated.

The on top of that he has a general legal obligation to act in the best interests of share holders.

But there's no blanket reveal all, and nothing that specifically covers his health and I'm not sure why you think there is or where it comes from. Could you quote the specific authority or law in question?
Call for Science Maps for the 2011 Iteration of the Places & Spaces
They're really old projects both starting around 1990. Scilab was not free software (commercial distribution of modified Scilab was verboten) until they switched licenses to CeCiLL with Scilab v5 (2008?) which is a FSF recognized free software license and GPL compatible.

Unlike Octave, Scilab's goal is not compatibility with Matlab. Unmodified Matlab code will not run in Scilab. One of the goals of octave is to run Matlab-compatible code. Scilab has a comparatively limited syntax relative to Matlab and Octave. Octave's syntax is more expressive than Matlab's but currently lacks the new classdef OOP (Octave does have @class OOP) . The last time I checked Scilab didn't seem to have any OOP.
Not at all. The timing on this was perfect.

Today is a holiday, so there is no trading... but it is a weekday so the press will have this thing over and done by the end of today. Tomorrow it is old news.

Tomorrow is also their earnings announcement. That will have a bigger impact on the stock than Steve taking time off.

Tomorrow they will talk about Mac App store results, 10 billion apps sold, Verizon estimates and drop hints about revenue from their new products in 2011 (iPad 2 etc).

This was well planned.
I thought the same thing, but what bugged me more was that changing the font changed their mind...seriously?
Show HN: Disrupt.fm - Music Distribution Via Facebook
http://www.disrupt.fm

I've been working on Disrupt.fm for about 3 months now and I just launched in Beta about 10 days ago.

I'd like to know what you guys think of the idea and any tips on how to market the site to bands. I've been emailing independent and unsigned bands telling them how the site works and I've been getting in contact with a few local bands.

Their responses have been mostly positive but I'd like some input on how I can continue to market the site to musicians.
That's true, but you need a combination of the two: both general and appliance-specific measurements. Like the post says: it's hard to figure out where power usage is coming from.
If you have more specific data and combine it with simple switching, you can achieve a much better awareness and higher savings. And the hardware doesn't have to be expensive as the "kill-a-watt" devices show.
Collecting UX souvenirs around the web with LittleSnapper
When there is snow and ice on the road the surface will is light colored (white or grey).
There's an interesting story to be told about what makes someone who's already a billionaire keep on in such a hyper-stressful job/career/calling when facing repeated life-threatening illnesses.

We, of course, won't get that story, and will have to settle for a news cycle of the fiduciary responsibility tourettes brigade vs. the hacks who think they're John Gruber screaming at everyone to leave Steve alone.
I love your site design - very cute :)

I'd definitely be interested once you got an Android app up and running - I use Evernote on Android and web heavily at the moment, and tried Springpad for a while (until it screwed up a sync and deleted all my notes, grr!)

Back when I was in Uni I used the analogue version of this: a big whiteboard next to my desk with stuff pinned to it or written in little lists, as well as using a sticky note app on my laptop. Pocket's visuals really remind me of that, in a good way, and from the teaser it looks like it would be really good for at-a-glance reminders and suchlike.
required but not unique. just generate a dummy one based on the user id.
How To break Kindle book DRM
Very nice looking apps!

And yeah, since Matlab is pretty much the standard it's a big plus to be able to use code from papers etc directly in Octave. Translating to Numpy is usually straightforward but it's definitely an extra step.

Numpy becomes very nice when you need to do some more general-purpose coding along with your numerical stuff though.
Thanks, I was just coming to ask for something like this.
First, a congrats on releasing your app! Seriously, I love reading about things like this, and people that do this always impress me.

> I am aware that the note app space is extremely crowded, but I have been thoroughly unimpressed with everything I’ve seen.

Personal itches are the best way to get started. After all, if your dissatisfied with what is out there, chances are, other people are as well. One of the worst things you could ever do is assume that just because a space is crowded means it's full.
Yeah, i was shocked, double checked the dates. I've been to the computer history museum several times over the years. Always at events, but still. I just assumed it'd been open for a long time.
There is a number that will cause you to walk away from the deal. Ask for something higher than that number. Walk away if they won't meet that number.

Your old salary is irrelevant, and only serves to anchor you in a lower range. Don't lie, just politely decline to tell them.

"I'd rather talk about what I'm worth to you".
Sounds like utter chaos for any seasoned professional. No QA? No real product managers (or at least none with any teeth)? Design as optional resource? Ops managing user engagement metrics? Where's the security audit?

Scary, even for a developer like myself.
I agree. One of the most important thing is that great PR means tons of valuable links. And in the SEO game, the formula is: "get the links, win the game".
The Pro hardware will have been setup in advance, but the pricing will be done very close to launch, and the launch was a couple of months after he left.

The MacBook that was a MacBook and then a Pro is a much more telling example, which you skipped over. A reverse-face like that after Jobs's return shows pretty clearly that they'd got it wrong in his absence.

iOS 3 brought the universally derided striped icons, which sounds like a minor point, but is actually the sort of attention to detail Jobs brings.

There's plenty more like that in there, but I don't think there's much value in such aesthetic quibbling. My overall point is that there was undoubtedly a difference in Apple's direction and approach during that time, and I don't think it was for the better.

EDIT: Cor, that's a lot of upvotes. The consequence is that Jobs now contributes so little to this perfectly humming Apple that he can leave abruptly amid a medical crisis and they don't make a mis-step? I don't buy it.
Here in the Netherlands it definately was a hot issue in regards to privacy. But likely the new meters will come: they could bring savings to the power companies by way of better knowledge of usages.
so just really curious.. what's the reasoning behind requiring it?
Apple's iPad 2 and iPhone 5 to pack dual core graphics
Chennai Online Florists
We are one of leading online gift shop for delivery of flowers and cakes to Chennai, Coimbatore, Madurai and all major cities of Tamil Nadu, We do same day delivery for perishable items like cakes, flowers. You will find a wide range of gifts for all kind of Occasions.
Sans-serif is almost always a best choice than serif for UI Copy. I'd left Arial as a second option in favor of Helvetica, though.

Congratulations btw, Roberto, you are a fighter.
I do love cmus, but I can't find a way to understand how it deals with some tags. Some songs are not displaying using the titleformat string I have. No idea why. Maybe they are missing a field? Conflickting ID3.2 tags v.3 and v.4? No idea. No time to dig deeper...

Still my main player.
Gul Panag Turning 30 Movie Wallpapers, Gul Panag Hot Photos, Pics & Images
Turning 30 is latest released Hindi Movie with Gul Panag in lead role. Turning 30 Movie is directed by Alankrita Shrivastava and important roles are played by Purab Kohli, Anita Kanwar, Rahul Singh, Jeneva Talwar etc. Turning 30 is the story of a woman who is about to enter into her 30's. The film deals with a woman’s natural needs as she is aging. It also talks about the societal pressures that add to the dilemma of a single woman in her late twenties.
This article is misinformed. We've been in the AppStore for the past 3 Christmas's and have noticed a significant spike each Christmas (30-50%+ increase sales) that doesn't really taper off. Sure the week between Christmas and New Years has the greatest spike (70%+ spike) but after that it returns to much higher numbers than before Christmas (ie., about 30-50% higher sales). Surprisingly, these numbers seem to carry on throughout the year until the next Christmas season and then you experience the same spike in sales. Throughout the year there are some ups and downs but it's pretty steady. Sure, piracy might have helped his app sales a bit, but he's wrong to discount the fact that the holiday season changes everything in the AppStore and it's effect continues on throughout the year.
The Elements of Retro Web Design
In today’s post, we’ll look at examples of work sourced from the wonderful Dribbble, which helps us focus on snippets of a piece, rather than the entire design or illustration.
iOS is stupidly better for monetization, and the demand for Objective-C developers is still very high.

Android users simply don't buy as many apps, and the pretty steep upper limit on app sizes mean several apps you can easily do on iOS are considerably harder on android. We've yet to see a project yet where android outsells iOS. (This very likely has to do with the wonky payment system for Android which started with very few nations and still isn't anywhere near Apple's numbers of participating nations. For Most non-US specific apps, they sell about 50% abroad 50% domestic, so that's a HUGE deal.)

The tools have a laughable difference in quality (XCode/InterfaceBuilder used to be a little sketchy for apps, is now pretty good, but eclipse is still eclipse, and graphical layout and editing is still very out there for android, but is the norm for iOS).

(I used to be an embedded Linux dev, I really wish android was doing considerably better).

That $1289 you'd spend buying a late generation iPod Touch and a white macbook is very worth it (or a mac mini even).
I suspected this for low quantity apps already but couldn't prove it as it might have been (or might still be) a statistical anomaly.

I had a non-appstore Mac app pirated and after a known "scene group" released a keygen and the app started to appear on known sites the sales actually increased. (Though it was nowhere near a 200% increase.)
Goldman to Offer Facebook Shares Only to Non-U.S. Clients
For office buildings, cooling loads are often significant even in winter due to the heat produced by equipment and occupants. Occupants present a surprisingly high load because of the latent heat introduced via the water vapor in their breath.
It's a bit more sophisticated than that--the keys won't start the car without the RFID Zipcard in the vehicle. So they've definitely tapped into the ignition system.

http://www.zipcar.com/how/faqs/faq?subject=how_to_get_keys
Advice to a college sophomore programmer
Group chat? I haven't seen that feature (OTOH I don't use Facebook chat so I might've missed it).