skysight-inc/HackerNews huggingface dataset:
The Seattle Institute for Biomedical and Clinical Research (SIBCR) in Seattle, WA has an opening for a research/software engineer in the field of image processing and analysis. This is an onsite full time position.

Responsibilities: 1) Developing/designing new algorithms for visualizing 3D data and assisting with data analysis and reporting. 2) Assisting in redeveloping/optimizing existing analysis software built in Matlab/CUDA. 3) Working with users to understand design requirements and incorporate user feedback into design revisions.

Requirements:

• Excellent problem-solving skills
• Excellent command over Matlab or Python, and C or C++
• Strong competency in version control (GitHub or similar)
• Strong competency in fundamental image techniques such as:
o Image processing (convolution, dilation, etc…)
o Shape analysis (statistical, principal component or Procrustes)
o Image manipulation in 3D environments
• Excellent independence and self-sufficiency (candidate will become the subject matter expert on various facets of these projects)
• Strong oral and written communication skills
• A bachelors degree in a relevant engineering or computer science discipline, with at least 2 years of work history

Qualifications desired but not required:

• A Graduate degree in a relevant engineering or computer science discipline
• UI development experience
• Medical imaging experience

The annual salary range for this full-time position is approximately $65,000 – $80,000 depending on qualifications, with benefits. Please note that this position is only open to U.S. citizens.

For more information / Qualified applicants should send a cover letter discussing the above qualifications (also briefly describing how this position supports their overall career trajectory) and curriculum vitae with 3 letters of reference to:

Joseph M Iaquinto, PhD Research Biomedical Engineer Center for Limb Loss and MoBility (CLiMB) VA Puget Sound Seattle WA jmiaqu@uw.edu
As someone who is healthcare adjacent they absolutely directly contributed to the opioid crisis.

Highly addictive drugs aren't a thing you just start and stop taking... Opioids are intensely addictive and Purdue repeatedly marketed Oxycotin as a non-addictive Opioid, there is even video of a Sackler talking about how much the sales team should be pushing the non-addictive qualities[1] as a benefit when dealing with Doctors. They also used the ye olde drug rep hard sell sales tactics to push it on Doctors in exchange for monetary compensation and in kind compensation when the US made direct monetary compensation illegal.

Purdue is a huge part of this crisis, but they shouldn't be singled out - the marketing that pharma companies engage is constantly contributing to the ill health of Americans through toxicity, unnecessary side effects, stress from financial pressures and, sometimes, direct poisoning.

Please do a bit more research into this crisis and it's causes.

1. Specifically, false qualities that Purdue actively hide evidence of.
They could be using money to deliver packages better (faster, tracking improvements, 24 hour delivery) instead of paying for China to dump products here.
Do it based on power then
From one of the article's comments: "Question: would you use BLUF in every blog intro? Storytelling intros can be inspiring, for example."

If every blog intro followed BLUF, then maybe I'd be actually interested in reading them. Storytelling intros only inspire me to lose interest immediately and close the tab.
There's a dual cause here: illiberalism is increasingly in vogue in our culture and politics, but early internet and tech culture were already heavily skewed towards individualism and independent thought: part of this was inevitable with the mainstreaming of the Internet and the fact that the average person is _far_ less comfortable with non-conformity.
> You don't think its true that before there were multi-core processors, processors could only execute one instruction at a time?

It is not true.

Instruction-level parallelism existed before multi-core.

> If you're going to do needlessly pedantic bikeshedding, at least get it right.

Pot, meet kettle.
0AD is pretty good.
My dad was career military. So was my ex husband.

This military communications standard probably goes a long ways towards explaining why people seem to either think I'm rude, crude and socially unacceptable or refreshingly direct with no BS.
I totally agree that it is a terrible title. Der Spiegel does very high quality reporting, but I got the impression that German journalist like to use sensationalist quotes as the title even more than English speaking ones do.

That said, I genuinely got the impression that Snowden is concerned that he might get assassinated and that his history of depression might be used covered it up.
Just as a caveat, I have 0 affiliation with Dropbox (I don't think I even know anyone who works there).

> Are they profitable?

Profitability isn't the end-all metric for a company. Amazon famously circles around the profitable/not-profitable line frequently and few people have doubts about Amazon's viability as a company.

Dropbox reported ~20% growth in revenue YoY and seems to have dumped most of that into R&D (you can see their R&D costs have grown by nearly as much as their revenue has). Other operating expenses remain mostly the same.

> There is no better evidence that Dropbox is just a feature than for the same price that Dropbox charges for 1Tb of storage, you can get the full Microsoft Office Suite for up to six users and a total of 6TB of storage.

Ok, but a growing subset of people clearly choose Dropbox. There are huge advantages to being a first mover that are sometimes insurmountable, even for gigantic companies. The zune was in many ways "superior" to the iPod, but we all know how that story ended.
If not college, though, your options are kind of limited.

Other (used-to-)pay-pretty-ok blue collar jobs are things like plumbers, electricians, and union telco work, if you can get it. Plumbing isn't too hard to pick up; I don't know if you need licensing for that (or why), other than a professional liability insurance policy of some kind. AFAIK there's still pretty good demand for plumbers and electricians, although I haven't done any kind of research on the market and expect it varies a lot by locale.
If there is something specific you would like people to do, please do go ahead and advocate for it. What organizations do you support, and why? Not this content-free guilt-mongering, it doesn't help anyone.
Piercing the veil isn't fraud either. But it can make you personally liable for the financial liabilities of your company.
https://selfhosted.show – a podcast about self-hosting internet services
Hell no. It's even crazier and more blatantly unfair since there's less monitoring and less need to save face and maintain the illusion of fairness.
A hyperloop to the moon?
> In a world before multi-core processors, these threads weren’t actually running simultaneously

He's trying to describe the difference between multi-threading and multiprocessing to introduce the idea of task switching. But the bad history lesson is distracting.

There were long periods of history when most hardware vendors had at least one model with multiple processors, and there were some companies that specialized in them (Cray, Silicon Graphics, IBM, Fujitsu, Toshiba?), including ones built with x86 processors (Sequent, IBM).
Dunno how much the US FDA is to blame here: these API plants pretty much supply the world with generics.

If anything, it's the FDA that's doing foreign plant inspections and every other country's regulator just does what the FDA does.

My real question is: Why is each country doing its own inspections? Why not one global inspection?

Everyone else is getting a free ride from the FDA's work.
The Mind, Explained: A Netflix Documentary Narrated by Emma Stone
Doesn't sound too much different than traditional inverted pyramid news style.
The point being made is that it's some mathematical thing, more fundamental than human nature, things that aren't human mediated behave this way too.

Think of the transmission of a disease as the percentage of the population immune to it decreases. Island infections isolated by being unable to reach new susceptible victims fizzle out. But above a certain susceptible percentage, the infection can leap from group to group along the edges where they touch, and it becomes a pandemic.

It's no just that the internet mirrors the real world, although it does. It's that it breaks down isolation barriers in the real world which used to passively defend against the spread of all sorts of unrelated corruption, everything from Nigerian prince scams to bitcoin wallet stealing to nation state disinformation.
the free carbon soil test is used by many farmers to evaluate the amount of microbial life in their soils. Several I have spoken to have expressed interest for a more reliable field test for microbial health in their soils. One side effect is that microbes in soil tend to help soils hold more water.

OP is right, though. Net mass lost is still a major problem.
While Cramer is known for his braggadocio, he's not wrong here. WeWork IPO doesn't pass the smell test. It's possible that WeWork ipo could trigger a huge correction across all of tech, and have rippling effects for many private companies looking to go public.
The rise of internet enabled microtransactions and the masses bought drm laden games they didn't own like mmo's...

Once the masses fell for mainframe/dumb client, companies now controlled the software and could insert bs monetization.
Thank you for noticing! Honestly, I like to be subversive (because if I can, why not!), and I also genuinely think it is a good thing to remember that as you allude, "we all die" or more to the point, "no company/product/language/technology is guaranteed a forever."
How does this shared cache work? and how does it solve the throttling problem?
Wiring money to yourself right before declaring bankruptcy and telling the creditors "Oh darn, I don't have any money" is absolutely a form of fraud.

Purdue is going to declare bankruptcy eminently, that is one reason the settlements here are so soft - the government is trying to get what it can before they offshore everything.
Can you elaborate on this? I’d love to actually use types in Python.
drink, not sleep (too late to edit)
I've been doing this for a while and didn't know it had a name. Sometimes I add an explicit snarky heading like this:

TL;DR: <Main point>

<Long explanation>

However, when writing comments on HN or other forums I go for what I call a "fireside chat" approach. Complete with metaphors, euphemisms and lots more sarcasm. Mostly because I find it more entertaining and enjoyable.
Talk to a lawyer.
> "You can be sure I was pushed" is an aside, and has little of the connotation the title has (that Snowden truly believes he's at risk of being assassinated)

The vehemence of his denial and insistence that it be on the record point to Snowden trying to get in front of any potential suicide narrative being used as cover for his assassination. I don't see how there's little connotation of that.
> if I had wanted to live a safe life, I would still be sitting in Hawaii in paradise with the woman I love collecting a huge paycheck to do almost no work.

Regardless of if he is a hero or villain, he does have integrity.

People that sacrifices their safety or lives to help a good cause are the ones I respect the most. I hope he will be able to visit his country safely sometime.

p.s. Please fix the title, it is clickbaity and almost unrelated to the actual article/interview.
I’ve worked plenty with drug addiction and am a recovering addict.

The idea that marketing is responsible for drug addiction is delusional.

The idea that doctors are so stupid as to not know Oxy is addictive is laughably untrue.

If you want to blame anyone blame the people ordering patients to consume opiates. The lack of supervision and education is the doctor’s responsibility not the drug maker. Every doctor in the US knows Oxy is addictive and has for a very long time. Doctors overprescribe OxyContin not pharmaceutical companies.

If you want to play a blame game there is no way Purdue comes out on top. Doctors are the ones who put opiates in peoples hands https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140023/es
The problem with how you're framing this is that the scientific methods that go into such developments don't take into account certain "externalities". Measurement and control can only be exercised inasmuch as you can understand the totality of the system. In this case: broader effects on human health and ecosystems. As someone with a strong scientific background, it sometimes seems to me that the science and engineering of the past couple centuries has been so focused on the intricacies of specific problems that they haven't left their practitioners enough leeway to consider their place in the constellation of human activity. I'm not saying that there would have been another way to accomplish these feats, but that the problems are so difficult that it's left to other (sometimes non-scientific) people to evaluate their value to society.
I'm sure they could just as easily route it through Mexican cartel channels or other commercial vectors just as easily.

At the end of the day it will never be economical to search more than even 1% package and port crate or non-commercial boat coming into the US shores. Those packages will still get through and millions of dollars of Fentynal can be hidden in small packages.

The supply of drugs to America has never been seriously hampered for long by decades of advanced drug interdiction tactics.
Perhaps the article is referring to the ancient world of a certain pigmentation?
This is something that so many dev teams have pined for. We wanted this as a dev team so badly when we were all acquired and wanted to move on from the acquiring company. Unfortunately in practice it's a lot harder than it looks. Acquihire is currently the best form of 'group interview' that I know of so far.
The term for this is literally "fraudulent conveyance": https://en.wikipedia.org/wiki/Fraudulent_conveyance#United_S...
Almost impossible to eat healthy these days. Even if you think you’re eating healthy you might not be. We aren’t getting as many probiotics, minerals, and vitamins from fruits and vegetables. This is terribly unfortunate. We need to find a way to use land more effectively and give our soil and plants enough time to establish themselves so the nutrition content is sufficient and normalized.

A solution might be less land for herding cattle and more land for planting vegetables and fruits that might take more time to cultivate.
Deterministic in this context* refers to the inherent error in conceiving of correlation questions as a limited set of discrete possibilities.

For example, given that event A correlates well with B one is likely to ask:

1) Does A cause B?

2) Does B cause A?

3) Does some unknown cause A and B?

Framing the possibilities in this way neglects interactions in which all possibilities are true to some degree. The author argues that all possibilities being true to some non-zero degree (A causes B and B causes A and an unknown causes both A and B) should be the more common expectation in natural systems. Therefor, framing problems in a way that suggests there are clear exclusions i.e. determinations, leads to cognitive bias and premature conclusions.

*As apposed the the common usage of deterministic in computer science where a process is said to be deterministic if every execution with identical inputs produces the same result.
Another good tool for this is the linear feedback shift register, and most programmers outside of crypto seem to be unaware of it too. A "complete" N-bit LFSR gives you 2^N non-repeating pseudorandom values. You start with some value (the seed), and feed it into your LFSR operation along with your chosen bitmask (the "taps"), and you get a difficult-to-predict value back out.

"Complete" LFSRs are created by carefully selecting your taps, and there's plenty of literature available for a broad range of taps for many different numbers of output bits.

Your cipher may have an LFSR buried somewhere in it, I guess they're a common component in crypto. (I know dick-all about crypto, mostly.)

Usual caveats for PRNGs apply: LFSRs are cool and magical and super fast, but the next number in the sequence can be computed by anyone else that can figure out your LFSR and seed, and since a complete LFSR will hit each value in 2^N exactly once per cycle, it doesn't even count as pseudorandom.

But, if you need a random-looking non-sequential non-repeating selection widget, an LFSR just might do the trick.
Spiegel has become one of the worst propaganda magazines (not for the government, but for highest bidder) in Germany. It was once famous for investigative journalism, nowadays the most relevant question is who paid most for the article.

Sorry for this rant.

Still, occasionally you'll get a really good article. This is probably one of those.
> But I would argue that Saban is easily 10x more important to Alabama's success than any single athlete on the team.

Maybe they should pay him 10x more than they pay the students then. What's that work out to? If the students are being compensated with free tuition, 10x that is probably a few hundred thousand dollars, right?
> Let's assume you could simply poke an icon and all the hidden activity would stop, would you do that?

> DER SPIEGEL: Of course.

That I think is the crux of the issue - our consent is not real.
Most of the gardening implements, and most of the cheap shower heads in my local home improvement store say they cause cancer. I assume people buy them anyway, or the store would stock something else.

So are these drugs with carcinogens of more concern than the other stuff? Should we be more concerned about the other stuff?
What about getting some Obfuscated Ruby one-liners, like the well known Perl Obfuscation Contests? https://www.foo.be/docs/tpj/issues/vol4_3/tpj0403-0017.html :)
My pet peeve with agile is it is so rigid at most places. Our team had a bug a while back. We all failed to understand something until it was getting QA'd. We told the PO that we'd need at least part of a sprint to fix it and asked if we could get that prioritized in the next sprint. You would have thought we'd asked to kill someone. We wasted a couple hours debating why it couldn't be finished in this the last day of the sprint. WTF?
"thrifty/crafty like Scottish people"
This stereotype hasn't been true for at least a generation.
Registrars still charge exorbitant prices for short domain names outside of com and io.
Flask Swagger already has a way to annotate it quite well.
> however I fail to understand why nobody really is up for changing this system,where millions upon millions left woth no choice but to struggle anything but basic medical care.

Plenty of people are up for changing it. It is quite literally the center of a huge debate at the moment in the Democratic primary, and there is a broad spectrum of changes being proposed, from Medicare for all with price controls to a slightly modified Obamacare. Only one candidate among those more or less supports the status-quo.

And the Republican party is currently avoiding discussing the way they'd like to change the health system (repealing Obamacare, fee for service care) because it isn't particularly popular at the moment.

Meanwhile, stories like the ones you see piling up in this thread happen every day.
Most of the metal fabricators I know are incredibly unfit.

I've worked in metal fabrication on and off for over 20 years, and my observation is that's a cultural thing combined with long running fatigue from working too many hours standing up. That and metal fabricators aren't known for their diet being particularly great.

I'm fairly active, both mentally and physically, never really drank much, and never smoked cigarettes. I could kick most of the guys I work with in the head, whereas most of them wouldn't be able to lift a foot above their hips. People usually guess my age between 6 and 10 years below my actual age.

Metal fabrication doesn't have to be hard on the body.

I entirely agree with you that the number one determining factor of how far you'll get in life--and by that I mean how well you'll do setting and achieving your own goals--is how driven you are.

And highly driven people tend not to hang around the workshop floor for very long, so the workshop floor tends to suffer a driven-person-drain by attrition as the highly driven people drive off to greener pastures.
Also, talk to your company. If it's a company trip, they may be on the hook this.
re WPF vs winforms: consensus recommendation would be WPF. But for something you're building for yourself, WPF has a lot of complexity that you may not get much benefit from. If you decide on WPF, don't use xaml! Separating dynamic UI into a static markup language is a complexity disaster that will cost you a lot of time. (Note that google results are dominated by xaml answers, so if you want code-only answers it's best to search github.)

Best approach may be a third option, at least as a prototype. Use Excel, with a RTD server that connects to TT. Uninstall the Bloomberg Excel Tools add-in and use direct calls into BBG's own RTD server, i.e., =RTD("BLOOMBERG.RTD","","VGA INDEX", "LAST_PRICE") instead of BDP(...) for market data (~100x faster), and you can get to an 80% solution very quickly.

re F# vs C#, I had used C# for a decade before switching (after I had a vacation ruined because of a multi-threading bug in our position-sizing model. Multi-core parallelism is much easier in F# due to default immutability). If you play around with the F# REPL you'll pretty quickly find out whether the language fits your mind well or not. For me, as soon as I read this code (http://fssnip.net/5I), I knew I had found my native language.
Kaiser covers ER trips to other hospitals (I think they are probably required to by law). Any other Dr visit needs to be at a Kaiser though and it is def to your benefit to try to make it to a Kaiser even for the ER if you can.
My experience has been fine with Kaiser for an out of network ER visit, I just got charged the standard copay. CA law seems to specifically protect those of us on HMO plans: https://www.sfchronicle.com/bayarea/heatherknight/article/SF...

"""
Under state law, the practice of “balance billing” — sending a bill to a patient if his or her insurance company doesn’t pay the full requested amount — is illegal for people insured through a health maintenance organization. Kaiser is an example of an HMO, a network of doctors that supplies services to its members.
"""
In what context would they want to have a character wearing swag from a defunct startup? (I've only seen up to midway through season 3 btw.)
File this under design anti-pattern.
> I guess could happen to a small degree based on the structure

There's no N-N bond in ranitidine. And nitration/amination isn't a metabolic pathway for good reason.

Must be a funky re-arrangement reaction if it is from breakdown.

My money is still on side-reaction from synthesis.
You gotta be careful with it, though. Excessively high concentrations of potassium can cause hyperkalemia, which can be lethal. That's why potassium supplements aren't sold in large doses; potassium bound up with fiber and whatnot slows digestion and absorption rates, minimizing the chances of an adverse buildup.
Also terrible with mental health from what I hear.
Perhaps "You deserve jump pay for time spent in training last year"?
Honestly, for me now, neither of the big two political parties, at least at the federal level. Join any organization that fights for your constitutional rights: all of them. People have to understand that these interests are so entrenched and powerful, and the game is so rigged, it will only get worse.