skysight-inc/HackerNews huggingface dataset:
> The European estimate on rare diseases is more realistic and 6-8% of the general population has a rare disease.

But not the same rare disease.

Orphan drugs collectively may benefit 10% of the population, but not individually.

Not that I disagree with what I think is your main point: a profit driven medical industry hurts those at the extremes, relative to those in the median. I don't know how awful that is or isn't. 100 years ago, those folks would just have suffered. It's a profit motive, in some part at least, which has fueled advanced treatments. If all healthcare and healthcare research were socialized, maybe the expensive treatments wouldn't exist at all.

What I'm not sure about is if you are critical of, or in favor of, this collaboration. Bringing "commercial-grade" AI to healthcare sounds like a good thing to me on its face. I've read here and there (perhaps it's sensational, but still) how some AI can be order or orders of magnitude more accurate than doctors when evaluating x-rays, or scans, or other diagnostics.

My worry here is in the profit motive of Google and the fact that, well, they suck these days in that they do not care about user privacy.
Or ebay. I got one for my dad last week, new in box for $165. For his light usage (calls, texts, maps, and photos), it works great.
https://www.technologyreview.com/s/534866/why-we-dont-have-b...
Cloudflare must stop being the 'service of choice' for bad internet actors
Time for someone into building that to start a Kickstarter campaign or something
I'm missing SPARK, the restricted and formally defined language based on Ada, extending Ada with contracts and aspects, and disallowing the insecure parts.
https://en.wikipedia.org/wiki/SPARK_(programming_language)
This is the real highlight of Ada.
AI Chip Duel: A13 Bionic vs. Kirin 990 5G
435 of their real employees or fake employees?
Tera: The Future of Living on Earth (and Mars)
Correct.

Brandless even fired their CEO back in March of this year.

Wag founds are off doing a mobility startup, got kicked out as well.
Apple has increased battery life every year since the original was released haven't they?

This year is a 4 hour increase, which is actually pretty huge.
I didn't say severe, but there are environmental impacts:

https://en.wikipedia.org/wiki/Environmental_impact_of_reserv...

The biggest is the destruction of migrating fish habitat, sometimes reversible with specialized structures (salmon ladders), sometimes not. There is also some evidence for increased CO2 emissions from artificial reservoirs.
Pixel phones don't have facebook preinstalled
If you’re young, single, and healthy, it’s better than nothing. For anyone who has non-trivial commitments, it’s not going to support being as cavalier about quitting jobs as was suggested up-thread.
Duplicate: https://news.ycombinator.com/item?id=20927832
I was always wondering about MWI and couldn't find the answer to one question. AFAIK Everett never mentioned Many Worlds in his paper. What he was talking about was a Universal Wave Function. In that sense, 'world' is just a 'quantum system', not 'Universe'. At what stage we started calling it Many Worlds?

When scientists say Many Worlds, do they actually mean Worlds as physical 'parallel universes' that pop up into existence?

Or they only mean that those are probable outcomes of our measurement (probable histories) that never actually happened (only one of them happened - the one we end up being it)?
I also have a 6s and am going to start watching for X-series iPhones on Swappa, mainly as a camera upgrade. My wife has an XS and her kid photos are a good bit better.
Same here. I sleep with the watch on and charge it while I shower/get dressed. I usually get a full charge during that time and, most times, the watch lasts way more than 18 hours.
"Apple is also working on its first low-cost iPhone since the iPhone SE. That could come out as early as the first half of 2020, the people said. The device would look similar to the iPhone 8 and include a 4.7-inch screen." -- https://www.bloomberg.com/news/articles/2019-09-05/apple-wor...

According to gsmarena.com iPhone 8 is 4.7" and SE is 4.0"
I wonder if you'd find the Xperia Ace (or an XZ2 if you want used) close enough for you. I think the Xperia line is where I'll be looking for my next phone, personally. https://phonesized.com/compare/#632,968

Edit: additionally, it looks like the Xperia is thick enough to have no noticeable camera bump. Has a 3.5 mm jack too; I like the look of this quite a lot.
Slightly tangential, but this comes to mind:

We are not here concerned with so-called computer 'languages',
which resemble human languages (English, Sanskrit, Malayalam,
Mandarin Chinese, Twi or Shoshone etc.) in some ways but are
forever totally unlike human languages in that they do not grow
out of the unconscious but directly out of consciousness.
Computer language rules ('grammar') are stated first and
thereafter used. The 'rules' of grammar in natural human
languages are used first and can be abstracted from usage and
stated explicitly in words only with difficulty and never completely.

--Walter Ong [Orality And Literacy]
Oh, my bad. It's TechCruch... so they're allowed.
Caches effectively do this some data. Certainly for read only date.
The pedantry obviously isn't relevant to the discussion, but just so you're clear why everyone is calling you wrong: "exponential growth" refers to a function of x that goes as C^x for some constant C, not one that goes as x^C. The latter is "polynomial" (of which "quadratic" is the term used when C is 2).
My previous watch that I used prior to buying the Apple Watch was a Garmin Vivoactive, which I used for marathons and 2 50K trail runs. It never came close to killing the battery on any individual run that's about ~6 hours of continuous GPS usage.

On top of that during a normal week of milage (~50miles) I would only take it off to charge once after my Saturday long run.

Regardless my point was more that I consider that solar technology to be much more deserving of the title of "innovative" regardless of it's performance (things get better over iteration) than an "always on display" something that all of my Garmin watches I've owned over the last decade have done.
The irony that we'll be using CloudFlare to connect to websites where we are blocked by CloudFlare for using an VPN.
By implementing it at the beginning of a UX paradigm cycle when the numbers of users are small, curious and in learning mode. Like how right-clicking was introduced when the number of Windows users was like 1/1000 of the number of the peak number of Windows users.

You don't implement it during/after peaking of said cycle. That's some crazy level of delusion/arrogance. Turns out not even Apple can do pull that stunt.
Might be worth mentioning Light contributed to the camera(s) on the Nokia 9 Pureview.
I barely can browse light html pages. See youtube is impossible slow.
At this point it seems pretty clear that if you are serious about endurance sport, you should get a sport watch, not a smart watch. The sport watches can even play music over bluetooth these days.
Serious question: Why would anyone buy the Pro when you can get the iPhone 11 itself for $300 cheaper?
This is what I miss too. Sleep Cycle alarm clock used to do that for me but it stopped working a little while ago and I can't figure out why.
I do not own a phone with a notch, but I’m under the impression that most video content is not wide enough for the notch to cut into the video.
I think you have the option of zooming in a bit to remove black bars on edges; with the drawback that corner pixels and the notch area are lost. Same as any other non-16:9 phone
His point it seems, was that strengthening Googles position (by making it harder for competitors to comply) was a price worth paying for stronger privacy protection afforded by the GDPR legislation.
Halo: Recursive Proof Composition Without a Trusted Setup
This is true, the only reason I noted the LTE was because this gives me access to my entire Apple Music library on the go. Perfect for the indecisive listener like me! :)
Why would someone whose been tasked with a job that is involved with gathering as much money as possible, be willing and able to just turn that part of their personality off and start giving money to someone else? Why would they do this just because its investor's money rather than customer's money?
The thing is, all this really does is promote spamming and self promotion, its of no real direct benefit to the user.
They've got the rest of Google's software preinstalled on the other hand. I don't want every single Google service on my phone, and some of them you can't uninstall.
You should move to Canada or Europe, they'll take care of your rare diseases.
I lost @simon in May 2019 [0], and I am now (hopefully) very close to getting it back to me, after countless tickets, emails, back and forth, etc.

[0]: https://medium.com/@simon/mobile-twitter-hacked-please-help-...
Re: Добрый вечер
Scientists Develop Alzheimer's Drug That Regulates Gut Bacteria
Well, it's part of the test program in beta, for one.
Error 105 is an internal Chrome DNS-related error code, not an HTTP code.

HTTP 1xx codes are informational, not error, codes, and 105 doesn't exist.
Indeed, but that's a constant / predictable bias the you can easily correct for.
Collecting in the Age of Digital Reproduction
Detector should be empty at first. Can you please re-register? It might help
Let's wind this back. I can come up with any sort of scenario to justify a philosophical point. But the discussion didn't start there. You've presumably read the article this thread is on, and saw the comment I was responding to.

Your blackhat vs grayhat is a false equivalency. We know that this is a bad actor, and the mitigating factor isn't what why he did what he did or what he did with his ill-gotten gains, it's (according to op) that after he did an objectively bad thing (extortion), he did an objectively good thing(pointed out security flaws). I feel that's cold comfort at best, and problematic thinking at worst.

This whole thread seems to be me misunderstanding people or people misunderstanding me and it isn't fun anymore. Wish you the best, we're not really having the same discussion though.
Interesting! You hit the nail on the head. This is isn't easy at all. Too many things to think about and yes, I want believers, not negative Nancy's like Debbie Downer on SNL. I am looking for others that want to help me build something as big as Facebook but build it for the "people" the users. The people that need the application. And, I want to go global. Like I shared with the other guy earlier, you can go to https://abc.ciwise.com and login with user/user or you can login as a new registrant and then email me at dlwhitehurst@gmail.com and I'll activate your user account. The email is not currently working and this is just a POC for the container conglomerate. Anyhow, yes, I want friends and people that feel strongly about what I want to do and why. And, I've been looking but it's tough. My stuff is Java, Spring Boot, JHipster, and Mongo for the database containers. It's pretty performant for an 8GB Digital Ocean droplet.
Accelerating the GitHub Sponsors Beta with Stripe Connect
Firefox Private Network uses Cloudflare Warp, which discloses to origin IP address to Cloudflare-enabled websites via a HTTP header [1]. Does Mozilla use a custom version of Warp which keeps the IP address of users private?

[1] https://news.ycombinator.com/item?id=19544845
Hmm on further investigation I think most of the use cases I'd have for contracts are met by the borrow checker. Side effects are going to get wrapped in unsafe or be explicit in the function signature.
No it doesn’t. At least, it doesn’t go flat enough that it doesn’t disrupt wireless charging.
If you ask me as a European citizen (well until Halloween maybe :/) to suggest areas problematic to human rights with regard to the US then Guantanamo is in my top five. But then I'm 52 and watched on TV Blair and Bush (aided by a compliant press) crowing about the use of "Gitmo" as a place where captured "combatants" were going to unlearn their ways....forever. Some of the captives have been in that shithole getting on for eighteen years now with no hope of a fair trial.

So I think for a lot of folks Guantanamo does ring a fairly loud bell.
Meteor burst communications

https://en.wikipedia.org/wiki/Meteor_burst_communications

Meteors punch ion trails through the atmosphere that serve as antennas for various purposes.
No, bring back the iPhone 4S. It was the perfect size and shape. You could even stand it on its side, due to the flat edges. And the square corners made it easier to grip.

Even the iPhone 5 was too big.
The oldest Gen X is almost 60 now, many entered the workforce when there were still defined benefit plans. But you're essentially right, most missed the boat.
So? Musk and Brin are also well known sex offenders. Musk even on the darker side.
Some people are in and out of the shower in less than 5 minutes, others 60 minutes.
I mean, my gaming PC has roughly the same cycle, though I suppose that's only for given parts, not the entire thing each time.

I dunno, for all the uses and advantages my phone gives me, I'm happy to pay. My last one was an X and it's served me extremely well since I bought it at launch. I passed on the XS, but the 11 is tempting.
It sounds like you're saying saying that "orphan drugs" can benefit 10% of the population and are also "cash cows." Do I have that right? I ask because if that's true, it seems to me that this is a good thing. If it wasn't a cash cow, would companies still be incentivized to take on the risk of researching these drugs and going through the work of having them tested and approved?

Your post seems critical of Google, but I don't know if that makes sense. Isn't your main criticism with the healthcare system and laws surrounding it? I don't know if we can blame companies that operate within existing law. The blame should instead be passed to policy makers and their voters.
Next up, TLS certs for the random hostnames?

Are there security implications to this?
My observation is Apple waits for someone else to make the hardware innovation (e.g., camera under screen being the next example of this), then they do a more polished version of that.
But at what rate is the water cost increasing? The infrastructure can be a fixed cost. With decreased consumption (grey water conservation etc), fewer are paying for the existing water. So the price goes up. That part makes some sense.
It was the first thing that came to my mind when I read about xip.io!
Live Photos are probably the best feature to ever happen for parents. They are pure magic.
Odd considering Kong is based on Nginx and this is built by Kong.
These sources do not seem credible.
Maybe we just aren’t the target market for Apple phones.
More complex end applications / Products require more complex infrastructure. Just as true with physical world as with digital.
Oh, nice! ツ I'll check it out.
I actually have heard it is better to use headers for versioning. Here is a link with three options for versioning: https://restfulapi.net/versioning/
Meh. I've run a marathon and several half-marathons while simultaneously not loving the act of running itself. A lot of the benefits come after a run, or from achieving a goal.

Through training I repeatedly tell myself (and believe), 'it is the hard that makes it good.' Not everything worthwhile is going to feel like sunshine and rainbows all the time.
Presumably because the board (which represents the investors) would be displeased.
Iwahai – Map Audio Recorded Launches Free Web Version
Iwahai, the geo-tagged voice memo app for Android and iPhone has launched a free web version with all of the publicly shared markers on it. Listen to the web.
I work for a company that does kinda similar software stuff for vehicles - Uber has about two orders of magnitude more drivers than my company, but about three orders of magnitude more engineers - it's almost like they've got diseconomies of scale.
I'm trying to figure out what the (presumably bad/unpleasant) f2p game trade-offs described in the article actually are; I think they are:

1. Fun vs. money (you can pay less money, but then the game is less fun)

2. Game success vs. wasted real life focus/time and constant worry/interruptions (if you don't constantly babysit the game and grind daily tasks then the game punishes you harshly)

3. Spending time/money on one game task/resource vs. another; this seems like an intrinsic trade-off, but segmented, non-tradable tokens and currencies increase the penalties for making a "wrong" decision

Out of the three, I greatly dislike 1 and 2. 3 is tolerable if the game is reasonably transparent about cost/time vs. reward The issue of a game surprising you with awful grinding/spending roadblocks seems like a special case of 2/1.
An improvement with no real innovation.
I have it at 1500. I set at 1360 and not see a change.
iSeries plenty of them in Portugal, part of my high school internship required doing backups of OS/400, used to be quite common across medium size companies.

The old Cray has "died", they just assemble Linux/Windows HPC clusters like everyone else.
A two seats version of this car with some more range would be a godsend in congested cities. Sort of an electric Smart at half the price.
Adding simple emoji signalling for avatars would be hilarious.
They would have found another, probably less elegant, way to do the same thing. E.g. they'd put the extra info in HTML comments.
"I have zero faith in the courts’ ability to distinguish this. In the case of Uber, their business is providing the back-end, and their revenue is a commission for doing all the back-end work. They are not in the business of driving cars — no Uber employee drives a car — and yet this bill would make the car drivers employees."

I find this an interesting interpretation of how Uber defines their business. If Uber only provided the back-end for their work, the common consumer wouldn't know about Uber, you would know the driver directly and reach a deal with the driver directly. I would relate this most closely to things like in China where you can pay via WeChat or elsewhere with Square where they just facilitate the transfer of funds. They would be a distant party to the work actually being done.

Instead the average consumer knows Uber, goes to Uber with the goal of fulfilling their need of getting personal transport door-to-door, and the act is delivered by their contracted driver. They expect Uber to handle the complaint escalations, money handling, route planning, and basically everything related to that goal. If Uber provided only backend you could create your own frontend/theme to Uber for your local town (like you would a wordpress for a SMB) and create a business around just that. While there may be some back and forth on interpretation I think the real test is that based on all those steps that have to happen if the ride itself was omitted from all the services they created would Uber still be able to function and the answer is no which would make it part of the "usual course of the hiring entity's business." If Uber (not counting their other lines of business) didn't actually arrange rides for people, they aren't a company providing a marketable service anymore.
For me it has ~ 17 hours ;)

But yeah, if you want to live with it 24/7, it can be a problem;
> It's remarkably easy to make fun of WeWork

Exactly. I don't understand all the schadenfreude about this company. WeWork is a basically good idea that seems to fill a real need, they just couldn't make it work in the economic environment they found themselves in (which, to be fair, is mostly about the "funding environment", and thus sort of an own-goal given that they didn't "need" to take all that cash).

That said: I don't know that I agree with the 2000 crash analogy. My feeling at the time was that the venture investors were a lagging indicator. The crash started in the already-public stocks at time when angels and VC's were still desperate to make deals.
I decided long ago that I won’t work for places that can’t be bothered having decent offices, whatever they do, whatever they pay *

I don’t mean candy bowls or flashy sofas, but well lit, well ventilated, with decent toilets, noise isolation and living space between desks, and ergonomic chairs (at least adjustable in height and depth/inclination)

Cheaping out on work environment is the first sign of misplaced priorities IMO. Especially when it’s so easy to get penalties from work inspection.

* I’ll settle for a million dollar a year, I confess
They just removed photos showing in drive, you still get unlimited photos/videos in original quality with a drive sub.
If they heavily rely on their own tools, odds are good maintenance will continue.
I have a Garmin FR 945, keep most sensors on all the time. I used it on a 2-day, 25 mile hike while recording everything and using its navigation and maps to figure out where I was on the trail for a good chunk of it, about 11-12 hours of recording, and it still didnt hit low battery by the end of the next day.

Generally I charge it every night or every other night so I don't know how long it stacks up against its estimates, but with some activities sprinkled in I think it's fair to say that a "1 week" estimate is closer to "4-5 days" if you’re active, depending on how long you're actively recording activities for during that time. As a plain smart-watch without tracking an activity or listening to music, it's down about 10% at the end of the day on those sedentary days, so I think that’s pretty in line with its numbers
By Edward Niedermeyer
September 9, 2019

Oh. Nevermind.

----

Edited - from the downvotes, it appears that people are not aware - this is the same guy who was the editor in chief of truthabout cars when they ran their infamous "Tesla Death Watch" / Tesla killer articles. He constantly re-iterated that the company was doomed before the roadster, then before the S, then before the X, then before the 3. He accused the company of Fraud in 2009, and has heralded every single vehicle from this to the leaf, to the Taycan and i-pace (how's that working for you Audi?) to the Fisker Karma as "tesla-killers".

How about articles like this:

https://www.thetruthaboutcars.com/2009/04/teslas-model-s-pon...

He's about as accurate as Elon Musk is punctual. He appears to be the natural anti-matter to the most extreme of the Tesla fans.

But remember it's Toyota that is actually the disruptor:

"Toyota is no stranger to disruption, having overturned the global car business over the course of decades. But rather than high-concept, visionary technology and hype, it was Toyota's mastery of the culture of manufacturing that drove it from bit player to industry titan. Toyota emphasizes kaizen, or continuous improvement, not Musk's mercurial style. And based on a scan of quality complaints at various Tesla owner forums, it seems Musk could learn more from Toyota's automotive disruptions than the other way around. Auto industry success is a marathon, not a sprint ... and at current volumes, Tesla is barely walking."
This flaw in ssh has been known about for ages, and has nothing to do with Intel, and putting data in cache is neither Intel-specific nor a "weakness".
Roughly speaking, San Francisco has approximately as many children aged 0-6 as they "should" given their adult demographics, and half the older children. The likely culprit is public school desegregation policies, which result in schools that are excessively far from home. Parents have to choose between making their children endure an hour or more of commuting each way, homeschooling, or moving out of the city.

I don't blame them at all for moving out at that point.
(I don't work for Mozilla) The rumor I've heard on HN over the past few months is that Mozilla eventually intends to sell a paid version of Firefox with a VPN included. I'm suspecting this may involve a Firefox Account in the future.