skysight-inc/HackerNews huggingface dataset:
I honestly don't know so that's why I'm asking:

Have the "Biotech Startup" companies changed much in biotech yet?

As the article describes there is sort of a merging of the concepts behind tech startups and biotech startups but some of the "biotech startups" I've seen seemed to be things like a fancy CRUD app for biotech and they just wanted "biotech" in their name to seem cutting edge. That makes it hard to know who "Biotech Startups" even are.

Other situations where we've heard about traditional tech startup culture applied to biotech where the leadership did not understand how incredibly iterative / random biology research can be and how that greatly influences the speed you can move at. Where you can take lots of data and come up with some results in tech as computers are predictable, biology tend to throw a lot of curve balls making all your data wrong when you least expect it.

Have "Biotech Startup's" show enough promise to get to this next stage in the first place?

It seems like the traditional Biotech industry is way more complex to break into than say putting a web-application product in someone's face.
It's advertising as an extension of a personal brand. Just look at all the teens etc sporting airpods etc. It's the same as it was 15 years ago with the iPod earphones. I can afford this so therefore I'm a step higher on a social food chain.
I once met a guy who was a programmer for a hedge fund. The strategies and knowledge he had would be very useful to competitors. They didn't have a non-compete agreement in the contract, as this is almost never enforceable here, instead he agreed to a six month notice period - after working two months' notice they then paid four months' salary for him to take a holiday while his knowledge became less and less useful to a competitor. I guess the strategies these guys use only have a limited shelf life but I don't really know much about this sort of work.

Perhaps that sounds like overkill but it feels a bit more reasonable and more fair to the employee - if you want someone to agree to a non-compete then you should agree to pay them for their time where they can't work.
> work can be done more efficiently to produce a more consistent result

Often with frameworks like React Native or Flutter, it means inconsistent UX bugs on each platform. Why do you think Facebook and Instagram and Airbnb abandoned RN in all their primary interfaces?

The "more efficient" implementation might lead to consistency across platforms, but people are pretty tied to the phones they have. Things like dropped frames, slow scrolling, UI locks, all have a subtle effect on the user whether they can point it out or not, and you're more likely to have those problems by diving in to these frameworks without understanding the underlying platforms.

This isn't argument to share no code whatsoever. But so many people who immediately turn to these frameworks either want to ship something at the expense of UX/design, their app is so small that it doesn't matter, or they have no idea what they're getting into.
Post Jio, India has one of the cheapest data rates in the world. Sometimes when you go elsewhere, one tends to accidentally turn on data and use it the same way as in India, and I have been bitten like this once. Luckily it was prepaid, so the damage was contained.
If I come across I blog I like then I tend to add it to my RSS reader but perhaps I am in the minority.

As for my blog, it is very unfocused and for every well-thought out post on technical matters there are half a dozen "check out these photos" posts.
At least in the German system, where you get an kind of official certificate from your former employer that also serves as letter of recommendation, I would never do an exit interview without having that document agreed upon and signed in hand. These things are slow to change, but are still being fought over in courts.
Don't time the market. Set up a long term investment thesis /strategy and allocate funds accordingly... Always. In good times or bad.
>So, what’s an actual sound strategy if you think a recession is coming?

If you've made intelligent investments you believe in long-term, then the best strategy is to do nothing. Sit tight and wait it out, whether the recession lasts 1, 3, or 8 years.
Trump to launch Crackdown on violent Video Games after Mass Shootings
Nationalistic flamewar will get you banned here. Please don't post like this to HN again.

https://news.ycombinator.com/newsguidelines.html
They were pushed out of Reddit and 4chan already, and they didn't go to Tor. That seems somewhat pessimistic. Garden variety nutjobs aren't technical geniuses, they aren't going to head for "underground" sites, they'll just go silent for lack of a community.

Again, serious, professional white nationalist terrorists or whatever will always have clandestine means of communication. But potentially violent nutjobs are only likely to become violent when they get egged on by other nutjobs, and by reducing the size of the nutjob community we reduce the threat.
Ask HN: Has Google Open Sourced Titan M Firmware?
This blog post https://android-developers.googleblog.com/2018/10/building-titan-better-security-through.html suggested that the Titan M firmware would be open sourced, but I haven't been able to find the source anywhere. Does anyone know if it is available?
If anything it’s scary. From what I’ve heard software engineering practices at AWS leave much to be desired.
I'm currently in the process of designing a simple Z80-based computer.

Same here, although I'm only at the point of trying to get things set up to program a X28C64 eeprom using my Arduino, so I can write the z80 object code to it and boot from that. I also just got the z80 assembler installed on my Linux box, so hopefully I can cross-assemble the z80 code, and copy the bits to the eeprom.

As for the actual CPU, my next step is to get the "test circuit", that just executes NOP's and cycles through memory addresses, up and working on a breadboard.

Baby steps...
2018 he published a mathematics book with examples in Python.
Fair enough. Thank you.

I was mostly addressing the regulatory environment. I do not believe (unless I am very mis-informed) that employee paid wages are at the back-of-the-line in a liquidation procedure.
Not a stupid question. The reason is priorities, but definitely our ideal to do predicate push down and join databases to files, streams, etc.
Please do not take HN threads further into nationalistic flamewar.

https://news.ycombinator.com/newsguidelines.html
I just started this yesterday and a quarter of the way in the main thought I have is that I wish I'd read this in college. Picking up this stuff all at once would have been way more useful than doing it slowly (sometimes painfully) over a decade.
Your example is the gulag example. If you don’t do what the law says, stormtroopers come in and take you away. Thats a free speech issue, but that’s not what’s happening here. It’s not even close. It’s not a slippery slope. It’s just… nothing. Nothing is happening here.

I tolerate zero suppression. But that’s not what’s at issue here. We are talking about a CDN company refusing business of someone they don’t like, because it exposes them to bad PR and likely liability as well. No one is required to publish your content. I can post my dick all over Facebook, and that’s fine, because that’s not suppression of free speech. I can’t walk into CNN and demand airtime under a flag of free speech either.

The closest thing we ever had to an issue of free speech on the Internet was when ICANN was handing over domains to the feds over piracy issues. In that case their was a thin line. In that case there was a discussion to be had. Property was being seized by the government and people were being arrested and imprisoned for what some considered speech.

Here there is nothing. Just whiny, uneducated people with no concept of what free speech actually refers to.
That's fair. I updated the text about OpenTrons. I didn't mean to suggest that all experiments could be automated. Today, as I understand it, it only really pays to automate workflows that you want to do many times.
"5 years tops."

- every AI experts since 1960
https://awealthofcommonsense.com/2014/02/worlds-worst-market...
No, it's pretty regular. It will even tell you to "try again" if you correctly don't select anything.
Then why there is no law for 2FA in the banks? In Turkey all banks must provide 2FA for logins. It is required by law.
I do think dogfooding in general is a good thing but I feel like it can hold you back if you're dogmatic--especially with a large company. Sure, people snicker when people found out MS uses Linux for some services. Same with Apple using Linux for their services when they still had xserve and osx server. I think both companies were better served by not being forced to use their own products.

I know someone who works at a Microsoft subsidiary. She'll bring up using MS Lync, Teams, Skype, Excel or something and I'll be thinking "oh, most companies just use X." The few times I've used those Microsoft products I found them confusing and error prone...this also means I should spend more resources learning this. All of that would take away from my day job.

I can easily see not wanting to spend time investing in half baked calendars and conferencing taking resources away from consumer focused features.
For long term investors, does this even matter? If your time horizon is 10+ years, it seems like this is just water under the bridge.
Not all of them pretend, many actually haven't heard about it. I know at least one older Chinese adult who came to the US for the first time recently and saw the videos on Youtube for the first time in her life. It was 30yrs ago has been pretty well suppressed by the censors.
Slightly older poster here. This is exactly how it felt when the bad times started in 1999-2000 and 2007-2008.

People will tell you not to panic and justify why it's different. For the most part, nobody has a clue. Make sure you can meet about a year of expenses including health insurance. This is always a good idea.

Also, these always last longer than you expect. This is almost self-fulfilling, because unless most market participants capitulate a bottom can never be reached.
Nice work guys. Especially now that more and more citizen - I don’t like that phrase, you know what I mean, though - data scientist start working with data, such libs are super helpful.
This is untrue. False statements are protected, wven yours.
Why would anyone protect an "unimportant" site with a captcha? The value of the information, to someone, in bulk, is exactly why some throttling is needed.
doesnt support POSIX character classes.

this should be preferred over `a-z` as the latter relies on users locale.
Thanks for answering my question so quickly!

That seems like a pretty good reason...I have been looking to learn some GPU programming to optimize some matrix math that I've been doing for a pet project, and while my first instinct was telling me OpenCL since it's portable, if people who actually know what they're talking about are saying that CUDA is simpler to start with, it might be worth it to me to pick up a cheap Nvidia GPU/Jetson Nano and do some processing that way.
For people interested in Consumer Biotech, here are more orgs to look into: 23andme, Ancestry, FitBit, Garmin, Apple Watch/Health, Verily, Oxford Nanopore, czbiohub.
Designr-Your Personal Celebrity Fashion Designer
We are a fashion tech startup from India in the process of developing a marketplace for indie designers. We have enrolled in the current YC Startupschool course that is being provided online and learning the nuances as we go through.

Our MVP(Designr) is on play store and app store where users can upload a pic, see which celebrity they match with and follow their fashion. They can also any celebrity trends for those that are on the platform. Currently, they will not be able to buy on the platform. We are targeting to enable the purchase by the end of August.

In addition, we also have a blog (http://blog.designr.me) covering the latest fashion trends

Looking forward to your review and feedback.
That itself assumes that the index measures the full universe of all economic activity.

Innovation and startups are themselves evidence that over long (decades) time scales, this isn't true. When a company in the index falls on hard times and folds, where did its revenues go? Frequently, it's to some startup that was privately held until a couple years ago. By the time it IPOs and gets included in the index, much of the wealth has already been generated, and its inclusion in the index is a transfer of wealth from passive investors to the founders, angels, and VCs who funded it when it was far from a sure bet.

A similar situation would occur if a younger generation decides that stocks in general are a scam and that they're going to put all their money into cryptocurrencies. I've met 20-somethings who actually say that; if enough of them believe it, it becomes a self-fulfilling prophecy, and all the old folks whose retirements are in indexed 401(k)s end up holding the bag as those investments become worthless and a younger generation ends up inventing a whole new financial system.
Your goal at any instant is to maximize the profit of your next few moments of investing.

This is only true for short traders or others who measure profits on a horizon measured in hours or less. For everyone else, the chicken example is pretty good, though the feasibility depends on the timescale over which you will be investing.
It depends on what your plans are for the money.

If this is long-term savings, I would invest it all into a balanced portfolio as soon as you can and forget about it - there are many portfolio examples out there that only use a few 'total market'-style ETFs, as an example. I too have sat on cash at times during the last couple decades and it has cost me a lot of returns. Trying to time these things is basically like gambling and it will drive you crazy.

If you plan to use the cash in the short-term or it's emergency savings, I would personally keep it in cash to protect the principal. High yield savings accounts or short-term treasuries will at least provide some inflation protection.
Show HN: Let AI write your first draft on any article topic
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He certainly did. Indeed, similar sentiments have been expressed before, and not always by nice people:

Voice or no voice, the people can always be brought to the bidding of the leaders. That is easy: all you have to do is tell them they are being attacked and denounce the pacifists for lack of patriotism and exposing the country to greater danger.

(Hermann Goering, commenting on the ease of taking a country to war regardless of its political system, during the Nuremberg trials)
I've experienced this indirectly, I was young and naive and figured it'd be best to be honest with why I left a prior startup I was working for, citing issue with my boss' management.

Turns out people in that startup knew my boss, didn't get the interview and was blacklisted from my prior boss even though we were on good terms.

Learned that lesson the hard way.
There seems to be a market for symbolic maths, too.

See: http://wolfram.com/
I understand what you're getting at, but this this horrible advice to the OP. Timing is not just "very hard", is extremely difficult, arguably approaching impossible depending on who you ask. I guarantee for the investor at the level of asking "What should I do in times of recession?" market timing IS impossible.
Vanguard Prime Money Market (VMMXX) or Ally Savings account. My money will be in VMMXX just because I already had a Vanguard account open.

Should get you ~2.2% return and getting your money out is relatively easy. IIRC you can even write checks against the account.
Hey! Yes, I have seen die.net, and it was a source of inspiration. I wanted to build something original, use Python, learn about astronomy, and maybe help someone else with their ideas!
The pride some people have in their ability to tolerate bad conditions is a little silly. I don't understand how you can look down on people who want a better work environment
I've only been holding out since ~2017, but I definitely see your point. I know I'm probably being irrational by continuing to hold out, and I'm suffering a bit from the sunk cost fallacy. I guess I'm irrationally avoiding the situation where I held out for two years, only to buy in at the top, and look like a total doofus.
No, it really isn't. You're trying to time the market, which is about as reliable as gambling unless you intend to dedicate your entire life to it. The parent post is correct, recessions are opportunities to buy what you were going to buy anyway at a cheaper price and get more for your money, provided of course you don't need the money for other purposes in the near future.
Been using RegExr for years!
This might not be so sinister. It so happens that "important" operations, like a class action lawsuit settlement, are also the type of thing you'd particularly want to protect from bots.
What is the best code-snippets manager?
There are plenty of stocks that don’t pay dividends.

Moreover living off the dividends and not the principal assumes you have vastly more savings than most people manage to do. For most people, they should anticipate to run down their principal in retirement, not just interest and dividends.
> How should we address this problem without cutting off things like 8chan, though?

We need to address root causes rather than symptoms.

Radicalization is often the result of in-group/out-group thinking[0]. What causes a person to develop a strong affinity for a particular group? What causes them to feel attack by those outside of the group? When we can answer these questions and others like it, we can start to cut off the problem at the source rather than playing a game of whack-a-mole. (And I fear that game of whack-a-mole because I fear that it may cause great harm to our long-term freedoms.)

I think a good start is fixing our political discourse. It's not radical ideas that are the problem. It's how we interact. It's how we address one another. It's not limited to "the left" or "the right." It's everywhere. We attack groups and people rather than addressing ideas.

In fact, I am first on the list of people who need to change. I started this whole thread by taking an unfair swipe at CloudFlare.

When we change our political discourse, those who value their identity with a particular group will feel less attacked and be less prone to radicalization.

This can be applied to CloudFlare/8chan in how CloudFlare went about it. CloudFlare dumping 8chan so quickly, arbitrarily, and without appeal will likely be seen as an attack on the in-group. This could be mitigated by reaching out to the 8chan leadership first. While CloudFlare might have cut them off in the end, at least there'd be a track record of making an effort to bridge their differences. And I think that would help reduce the impact this action would have.

0. "Mechanisms of Political Radicalization: Pathways Toward Terrorism." Source: https://www.tandfonline.com/doi/full/10.1080/095465508020733...
> Internet hate forum

I wonder if they'd describe themselves that way.
Next thing should be done, to provide a command-line interface, such as:

curl -F in=@stuff.pdf 'https://pdf.to/png' > stuff.png
Human Milk as “Chrononutrition”
Let's say your strategy is right and that if you could accurately predict a downturn, sell equity and buy REITs.

The lesson to learn from last time is not to avoid REITs but to choose higher quality ones. Buy high quality US Core (USRT) and residential (REZ) and if you want to diversity further (REET) is 1/3rd global. Ive also left out ICF, REM, IYR. Blackrock alone has plenty of ways to stick your money in real estate.
Debasing currency is a product of ensuring low interest rates by printing money. The Federal Reserve and the Chinese Central Bank neither directly loans money.
Distinguishing states of conscious arousal using statistical complexity
seriously, this is probably the least intuitive group to single out over this
Mine too. Which is also my employer (you can find out who that is easily). ¯\_(ツ)_/¯

Since both number are sent (separately) via physical mail, all you'd have to do to get them would be to wait around in front on the mailbox when the postman come, ask him he's got mail for Mr X, repeat for a few days until you get the monthly report sheet, on this document will be the first number. Now go online, ask for a new password. Wait around the mail box for the new password to arrive. The mailman will just think "oooh Mr X is such a good person, always saying good morning". Chances are the victim doesn't have any alarms set up on their phone. I have alarms set up.
Sondre Rasch of SafetyWing (YC W18) Shares Advice for First-Time YC Applicants
Disagree. This totally makes sense.

Yesterday people in America were buying TV's from people in China. Let's say the price of a given TV was $140.

Now that the CNY/CNH is 'lower' (in the sense that you now need more than 7 CNH to buy $1), the price of those TVs just fell.

Now maybe the price of the TV's at $140 was in some contract, but the next time the contract comes up for review, the lower CNY reflects the fact that someone in China will accept 'less' for their TV than they were yesterday.

Extend this logic from a 1% move to a 20%.

As prices fall, maybe people start buying more of their TVs from China than South Korea, cause relative to the price of TVs from SK, the Chinese TVs are now a 20% discount.

~~~

Now, whether a falling FX makes for greater or lesser demand for Chinese financial assets, that's a different story. Would expect this to prompt capital flight.

~~~

And finally, yes, currency does pay a dividend. Just usually in the form of a different interest rate. So for 'lending' to a developing currency (in the form of buying a financial instrument or holding a bank account), you generally earn the local interest rate.

When capital deems that country as more risky, then that is reflected in the yield of short term interest rates. Were you to lend to Brazil, you might want 1,2 or even 5% more than you get for lending to JP Morgan or the US Govt.

Now, the fact that this 'interest rate spread' doesn't really exist vis-a-vis China, well that's the whole issue at stake. If interest rates in China are too low, then you would expect people to want to exchange their CNY for USD, since why not put it in dollars if it doesn't cost you much. Again, hence capital controls to protect against capital flight.

Macro folks call it the 'trilemma' and we're seeing a real time experiment in it, on a massive scale, right here.

https://www.investopedia.com/terms/t/trilemma.asp
'We Are Not at All Prepared for a Pandemic'
> markets decline due to the assumption that the yield curve inversion is a perfect forward indicator of recession.

I don't think you are saying it is, just that the markets believe it is, but the funny thing is that it's not a perfect predictor of an oncoming recession.

While all our recent major market down turns have been preceded by a yield curve inversion, there have been plenty of times that the yield curve inverted and was not preceded by a recession.
The administration just agreed to a budget-busting compromise bill that breaks through the Budget Control Act limits.

Stimulus is already happening.
How software is eating care delivery for healthcare (A16Z)