skysight-inc/HackerNews huggingface dataset:
From the article:

> The new study suggests that life's dependence on these 20 amino acids is no accident. The researchers show that the kinds of amino acids used in proteins are more likely to link up together because they react together more efficiently and have few inefficient side reactions.

Note that this part is overoptimistic. Much more optimistic that the text in the research article.

In the research paper they analyzed a few amino acids like Lysine. Lysine is an amino acid that has the usual amino group and the usual acid group in one side, and it has an additional amino group in the other side. In the study they compared Lysine with Lysine-like amino acids that are shorter and the additional amino group are closer to the usual amino group and the usual acid group. For example https://en.wikipedia.org/wiki/Ornithine

They found that the usual amino acids like Lysine are better to form spontaneously protein-like chains than the shorter versions when they are in a solution that gets dried. I'm not sure if this is enough to explain why Lysine is used in proteins but it's an interesting result anyway.

In the more optimistic case, the research article "explain" why the 3 usual amino acids that they used are better than the 3 shorter variants that they used. It doesn't "explain" why the other 17 amino acids where selected.

In particular they used amino acids with an additional amino group, so the polymerization can get "confused" and instead of using the usual amino group use the other group, so instead of a nice chain, you get some other structure. There are 7 of the other usual amino acids that don't have an additional amino group, so the polymerization process can't get confused.
> Maybe progress should mean ensuring every human is healthy, fed, housed, and has access to education and the global network.

I don't think that's an attainable goal, or at the very least it's not a realistic short or long term goal. There are so many other things we have to fix before that goal makes sense.
Idea:

1. The browser introduces a flat monthly subscription, e.g., $5 per month.

2. If the user signs up, the browser would distribute the money between the extensions that the user has installed, by default.

3. The user would also have the option to direct the money to specific extensions and/or to exclude specific extensions from this payment.

4. This system would be completely optional, but the browser cold in return provide an advanced extensions UI with extra privacy and security options.
The fact that nothing can propagate faster than light speed, allows to isolate segments of universe from one another. Of course you can not simulate the whole universe exactly, but simulating a part of it, like completely closed room, or a different smaller universe, is still interesting and useful.

Wolfram proposes an interesting solution to the question of free will, that does not require any randomness: computational irreducibility. It is the hypothesis that for some computations there is only one way to perform. That is if you try to predict what an AI will chose, your only option is to create an exact copy and let that copy to make the choice.
I don’t have a problem with it although I think it’s good that they changed it. If drivers complain “we’re not getting enough tip” and the company says “OK we guarantee your tips will be at least $5 on this order” that’s the behavior you get. The customer feels ripped off by a program that ostensibly benefited drivers to begin with.
I do part-time work on a Django app, doing major work only once a year. It's creepy as, but I do find the Google results that are tagged "you've been to this page X times" shamefully useful.
Not everyone agrees with that. A lot of people think the efficiency of writing code in favorite language X makes up for the added hosting cost. I just don't believe it with how many choices are available now. Maybe that was true 5-10 years ago. Now we have a good 5 languages with maybe 40 frameworks that run less than 3x slower than C. That's really really fast. Enough that you could run anything under top 500 sites with a single machine.

Static CDN hosted react/angular SPA with a speedy backend can serve a stupid amount of traffic even on AWS free tier.
The article oversimplifies back end. If all it did was communicate between the database and front end then there are no difficulties. It would simply translate in two directions. In that case, front end would be much harder since it would be necessary to do all the processing there if back end only translates.
NYC is not in Canada. In the US, the 1st amendment would likely protect citizens from any such law like this.
I just love it when deft minimal art...spurs such comprehensive critical conversation. We need more of this on HN ;-)
Udacity Intro to Javascript course for learning the fundamentals. It also sprinkles in exercises that really help you push further.
Hong Kong is a cube and the US is a plane. Delivery costs are not comparable
OP should've said the running average is getting hotter every year. Next year may end up colder, but the average temperature of 2020-2024 will very likely be hotter than 2015-2019.
I'm so tired, I thought this was fish eggs.
Just FYI, CuckooSandbox has good integration with this,which is nice when you want to find undiscovered badness in your environment that talks to similar network entities as your sandbox detonation.
Careless or not, you would be charged as a military serviceman. The double-standards are obvious, but the wordplay makes good news fodder.

https://fas.org/irp/doddir/army/ar380-5/vi.htm

How the FBI classifies something, is wholly irrelevant.
OCaml is pretty sweet too, but I think it strikes a different balance. You end up with something more static of course, but I've found it to be quick to compile, and quick to run.

You still can't compare to the SLIME experience for CL of course, though tools like Utop are nice. That and a few other add-ons try to fill some gaps.
All Nobel Prizes
i'm on a 6s as well. every year i look at the new phones and i just can't justify paying so much for incremental improvements.

faceID is nice but touchID is just fine. 2GB of memory is fine too. and while i don't use the headphone jack much any more, it's nice as a backup for when i forget the airpods. i may upgrade next year with the purported 5G rollout, but i'm not even sure that's worth it. LTE is fast enough and its coverage is mostly good enough too.
https://emailoctopus.com | LONDON UK / MANCHESTER UK / VANCOUVER CA | ONSITE OR REMOTE

EmailOctopus was created in 2014 by two brothers. Today, we’re a small but mighty team on a mission to make email marketing easier and more affordable.

We're looking for talented devs who can write PHP and Symfony/Laravel. We're also (desperately!) looking for experts in big data.

Email jonathan [@companyname] .com
Agree! This is the main issue we've had as well at least when it comes to sharing personal docs with the team and viceversa. Is this what you mean?
> Hello lores.eu :-)

hacked?
I live in America, my apartment building has side sliding windows but people still have in window ACs (with an attachment, not to mention many places in America have central AC). Not that we are really apart of this heat wave being on the west coast.
VDFs don't replace proof of work. In essence, POW is a lottery where everyone gets their own random lottery ticket and the lowest number wins. VDFs, instead, allow a large group of people to all share a SINGLE ticket, which simply spits out the ID of the winner.

This is conceptually a completely different approach and VDFs therefore aren't susceptible to the same problems as POW (though they have other unrelated problems, which this contest is trying to mitigate)
They weren't "defrauding the drivers of tip money" they were normalizing the variance in payments across deliveries by not directly paying the drivers tips and instead guaranteeing a minimum payment amount which was above the delivery fee.

Once they modify their system and move to a system where drivers get 100% of the tips the drivers will probably see approximately the same payouts on average, just with higher variance across drivers. Basically what DoorDash was doing is the same as tip-pooling at a restaurant which isn't exactly a controversial practice.
>"the deepest thing I would like to communicate with you today...is we don't know how to design systems yet" ~ Alan Kay, OOPSLA '98

What would a Lindenmayer "toy" look like, I wonder?
That seems like a dream setup indeed. What can I say, try to get as many people as possible to enjoy it!
I love those books. I always seem drawn to these super expensive technical hobbies like astronomy and photography that are out of reach. You just cannot do them well cheaply and I've wasted money in the past on crap telescopes etc. The "lotto list" has a high quality telescope, tracking mount etc, and cameras right toward the top. One of those backyard observatories and the skills to make my own telescope properly would be a dream.
Network performance regressions from TCP SACK vulnerability fixes
This is one of the better language tutorials on he web, IMO. It's very conversational, and if the FP concepts don't draw you in, wondering what stupid thing he's going to draw in the next chapter will.
Fascinating facts to learn of, but sites like this one and LiveScience tend to interject too much extra content that is unsubstantiated. Adding in the bit about Caesar coming in, when he wasn't on his high horse for 150 years after these people died. Just because some general time period was 2,200 years ago, doesn't mean there isn't a significant gap between the ages. 150 years can change a lot. It's the time between the age of slavery in the US to today.

Then the bisexual (/poly?) suggestion and hedonistic remark. Citations or substantiation? Very unprofessional but I suppose these are online authors from no specific literary tradition. It was a Roman source that recorded a consort to a Celtic king that supposedly told Emperor Augustus's wife, “we consort openly with the best of men. You allow yourselves to be debauched in secret by the vilest.” Which is the hedonist? I'm American, of now-distant European Celtic & Germanic tribal extraction and while a non-expert, am knowledgeable enough in the subject to see when someone is interjecting their personal nonsense into an article.
Equally true for the plant-based patty, though, I assume.
> Headline is misleading at best, if the iPhone were to suddenly lose their market to Android phones, most of that subscription revenue would dry up too.

I think the title implies "iphone sales" and not the iphone as a device..
>We did some drills with our own Patriot air defense units and they said they had to set their radars so low they were picking up big birds.

I wonder if anyone has ever accidentally radar-locked a missile onto a bird and shot it down.
I like it! Im having a hard time coming up with solid indicators that Im debugging or otherwise in focus mode that wouldn't also be red herrings for other activity. Have you come up with any good examples for yourself?
1. Yes, that's true. The value increases, in that the more data that's available, the better the decisions that can be made.

2. So? Why should you have a choice in it? Those things are classified as public records, available to anyone.
This is rad. You can actually build a fairly secure vdf with a sequential hash function using intel’s sha256 instructions, and verify the output across all the available simd lanes.
OpenBSD ships with Perl (it's used for the package management tools, among - I presume - other things) but not Python, last I checked.

Not that installing Python is especially difficult, but still.
I'd also like to see Apple move beyond using the AppleTV and HomePod only as proxies for HomeKit, and start using them for on-device learning, backups, etc. "HomeKit Secure Video" suggests things might be moving that way a little. (And use my home computers too!)

I would still gladly pay for iCloud storage if it was mirrored on local storage. Seems ridiculous they got out of the WiFi router market; missed opportunity for this "edge computing".
Time will tell it seems. Norway is very invested in at least appearing to get out of the oil business and into renewables. Couple pretty significant moves include renaming Statoil to Equinor and rebranding all of their gas stations (many in Scandinavia are branded as Circle K now). Norway very much wants to get out of the perception of being rich because of oil.
> Most EDM is more either more formulaic or it lacks the strong melodies and inspired feel for structure and form that makes Kraftwerk stand out

Those qualities that make Kraftwerk stand out are what sets them apart from the genre of EDM! From a pre-2010 USian perspective, coldtea's comment is on point.

But looking up the term, apparently it does now refer to more than just one genre. But that itself feels like a forced result of commercialization - Wikipedia: By the early 2010s, the term "electronic dance music" and the initialism "EDM" was being pushed by the American music industry.

Unfortunately it's also exclusionary to electronic music that isn't primarily intended for dancing, which is why you're arguing over whether people were dancing to Kraftwerk.
Give neovim a try. Along with iterm gpu rendering, it's quite fast even with syntax highlighting and cursorline.

IIRC iterm2 has a setting to disable gpu rendering while on battery which is almost certainly your issue.
I don't think this is at all as serious as you think. I don't think this is the Zurich Office for Urban Development spinning a cute little narrative, I think it's more similar to the Corded Ware culture [0], where scientists identified a lot of clayware buried in corresponding times and places, and so theorized that the people that make them communicated and shared a culture. The timing, and the coordination, suggested that those people corresponded to the Indo-European spread from near the Black Sea into western Europe.

In taking two things (two pieces of clayware, or two people) uncovered with similar features, you are usually able to extrapolate more information than by holding each one in perfect isolation.

What's more, there's not a whole lot riding on this. The office said "Isn't this interesting, that two archaeological sites are so close in place and time". That usually doesn't happen, particularly that far back in time. If the Office had editorialized that they were lovers, or best friends, I would agree with you, but this is just saying "We can date them to a very similar time, and to a very similar place. They are intrinsically linked, and should be treated as being more close together than separate."

https://en.wikipedia.org/wiki/Corded_Ware_culture
Amazon already invested in Ethereum https://aws.amazon.com/managed-blockchain/
What the company should have done, ethically, is to just increase base compensation for drivers. You shouldn't be able to dynamically change base compensation based on the quality of the tip that the driver is rewarded, that is pretty antithetical to the entire idea of a tipping economy.
> "Reducing the data footprint of your website goes hand in hand with improving frontend performance. It is the single most reliable thing you can do to speed up your site."

It's been said before and needs to be said again. This article is an excellent and detailed explanation.
As always, a reminder that correlation != causation. This shows an association between hormone levels and autism, which is suggestive. But keep in mind that there may be a confounding factor or factors (e.g. the same genes that control synapses that are dysfunctional in autism may be involved in hormonal regulation).

Biology is decidedly unlike good code - no modularity, many pleiotropic effects. Something more definitive would be examining pregnancies where oestrogens were artificially elevated, maybe by looking at women who were unknowingly pregnant but continued to take oestrogenic contraceptives.
Progress is an illusion.
No such thing as progress.
According to the second law of thermodynamics things can only get worse we can only conserve what is good already before its inevitable decay.
Progress is snake oil, eternal yough, perpetual machines, ideal cities and so on : Utopias, scams, wishful thinking at best.
All this has the fear of death as a root cause.
One of my happiest purchases of the last few years was a smartwatch. It has a different vibration pattern for every type of notification, meaning I can set my phone to silent permanently and still know what's going on.

It's kind of empowering to receive a message and know if I even need to look at my wrist or not (let alone actually bring out my phone). Makes me feel like a cyborg.
I felt the same way about the name. I visited a coworker in 2014 and he was like "oh, hey, it's getting close to lunch, let's order some Caviar." And I was like, "uh, isn't that a little ritzy?"

Seriously, I don't know the logic behind behind that name.
Second this - I went from not even knowing what a shader was to writing some pretty complex stuff in a few weeks.

Some of the later tutorials are still a work in progress though, hope they get finished soon!!!
Buy Hydrocodone Overnite Delievery
And more granularly speaking, I have "Hey Siri" turned off. I do still use Siri, but I hit the side button to engage. (90% of my requests are "open the door".) Seems like a good balance to me.
Fun fact, Moloch's initial development was funded by DARPA Cyber Fast Track! Glad to hear it's working out for people in DOD.
I highly doubt many people want to drop nationalism completely (I don't). If however agencies like the UN can no longer raise a peacekeeping force to stop conflict spreading, that becomes a serious issue. Climate change is the trigger, but our tendencies for war are what'll bring the disaster when climate change really kicks in.
Without Paul Allen, Seattle Art Fair Opens to Questions about Its Future
I have real problems with TreeNotation advertising itself as "a software-less database system". It's basically abusing your filesystem to store a tree data structure and using git to handle concurrent updates. That's great, except for the part where they ask "does it scale"; and the answer is yes, but should be no.

A database is so much more than just a schema and validator, but this is being advertised as a database replacement.

And, I want to stress, that this doesn't mean I don't think it isn't useful. I bet there are lots of times where you want to enforce some sort of structure on a bunch of folders with files in them. That's not a database though.
That's very cool thank you. I seem to recall an astronaut on the ISS making something kind of related with parts on hand...Don Pettit I think?

*Found it: https://science.nasa.gov/science-news/science-at-nasa/2003/2...
Every pizza chain.
We (very) generally build with sticks and bricks with uPVC framed double or triple glazed windows. Double skin of bricks externally, one skin internally for load bearing walls and wooden "stud" walls for the rest. However there is a lot of variation after that. Modern building regs stipulate a lot (decent amount) of thermal insulation in roofs and acoustic insulation between floors and rooms if possible. When we had our 1920s build modernised somewhat, we had to have additional steels and wooden structure added to account for potential additional snow loading on the roof because it would no longer melt quickly.

Yes, we do get good passive cooling in general with this design. Some better than others. Half of the ground floor (first floor in en_US) of my house is tiled with underfloor heating. The dogs love it when dumping thermal overloading - it is cool to the touch regardless of air temperature.

Now, if I wanted to add AC to my house it would not need to account for window shape. I don't understand that comment. Slide up windows are called sash here in the UK and are generally associated with the Victorian era! To add AV I would simply get another consumer unit added to my home 'leccy feed. Then I would fit the internal air out in the primary living area and connect to the external unit by drilling holes in the wall. Not sure where the windows fit into this. Oh and I'd try and fail to get the wife to close the bloody doors.

Not going to happen - I'll stick to being British and whine when it gets warm.
It's only a cliche because it's so true.
> I’m so confused by DoorDash’s sudden rise. I think I may have used it once. What is separating DoorDash from UberEats, Postmates, Grubhub etc?

Network effects are pretty strong. Locally, I don't know anyone who uses anything other than SkipTheDishes.
No, this is the highest demand since 2017, with 2017 being slightly higher.

Which is pretty lame. I'm with alexilliamson. So it's the highest in the last two years? Color me unimpressed. I guess it's just the consequences of recency bias running amuck. "2017? That was so five-minutes-ago."
A couple of suggestions:

- Affiliate websites. These are basically content websites with built in affiliate links. You try to rank your content for certain keywords in search results

- Real estate. I've been a real estate investor since 2008 and I can say that it's probably the most well known way of building passive income. Simply put, you buy a house, rent it out and continue the process. However, it's a long term game because of the amount of starting capital required to buy. I wouldn't recommend it if you don't have much money to start because of the repairs and maintenance you will be responsible for as tenants continue renting.

I hope this helped. Let me know if you have any questions.
Can't most of these wires be replaced by WiFi?
My guess is that these facial rec systems aren't very sophisticated. I suspect that they just compare a sample image with their database of images, so as people age, they just look less like their image in the database, so the similarity scores will simply decrease as the data grows more stale.
Sure, management is a fine career goal, as good as any. But when many people say, "I wanna be the boss!" in the best case, it's some fantasy about control, and in the worst it turns out to be pathological. And those are the last people on the planet you want to be "the boss".
I think that the idea is that as much as possible everyone's preferences should be heard and allowed for. The preferences and priorities of people living in cities tends to be dramatically different than those of people living in rural areas. The concern is that a scenario where cities have enough higher population that their preferences are advanced to the exclusion of the priorities of people in rural areas, while more democratic, would undermine ideals of freedom, equality, self determination, etc.
Cepheid Variable
I think you have the wrong thread buddy.
My job is deploying and configuring Macbooks at reasonable scale (2000-5000). This article is nonsense.
This is true, Europe is behind in AC installations. Here in Greece most houses have AC as well as other means of cooling (shades, heat shielding, natural means...) but this is not so in Central/Northern Europe. I’ve also heard about AC installation companies expanding business up north where demand is growing year by year.
See below a small paragraph from [0]:
“Europe accounts for just 6 percent of the global share of air-conditioners, compared with 23 percent for the United States and 35 percent for China, according to a 2018 report by the International Energy Agency. More than 90 percent of Japanese and American households have an air conditioning system; fewer than 10 percent of Europeans’ have one. In Germany, the figure is below 2 percent.“
[0] https://www.nytimes.com/2019/07/25/world/europe/heatwave-rec...