skysight-inc/HackerNews huggingface dataset:
To the computer hackers who read these things: biology is a complex system. So complex that the most complicated system you have ever worked on seems very simple compared to it. WHen you read articles like this, be aware the scientists have extensive training in working with complex systems, and publish exciting sounding coherent narratives that are, at best, incorrect but useful working models (https://en.wikipedia.org/wiki/Not_even_wrong).

It's fun to speculate but to prove your case and make a real dent in human health problems is a lot harder than coming in late and saying "But wait, why don't you just..."

I heartily recommend going back to the great textbooks of these fields and reading them, rather than trying to understand things by dropping into the state of the art research (which is usually wrong, and hard to understand in detail).

Some books I recommend:
The Biology of Cancer (Weinberg). After you read this book you'll have a better understanding of why doctors and scientists cringe when people say "cure cancer".

Molecular Biology the Cell (Alberts, etc). After you read this book you'll have a much better understanding of the full complexity that scientists have to deal with in complex cellular systems.

Molecular Biology of the Gene (watson, etc). Can't say much about this book except that's it's a classic reference.

What makes these three books exception is that they support all their factual claims with direct links to the papers that established the facts. And they provide you with the skills to evaluate modern research. But nothing compares to actually going to grad school and participating in the research- once you see how the grants are made, the experiments are, and the papers are written, you'll understand why trying to understand biology by press release is like trying to understand assembly language by watching a Steve Jobs product announcement.
> IANAL but it sounds like he may be able to appeal based on a recent SCOTUS ruling[0].

For entry into the US on visa-waiver (ESTA) or visas (without a green card), you generally can't appeal to the courts, and court rulings about deportation aren't really relevant.

It is up to the discretion of CBP (and also the State Department for visa issuance). They can decide to disregard a criminal conviction - they are more likely to do that if it is relatively minor, if there are some unusual/special circumstances, if it is from many years ago, if a person shows evidence of being of good character since then. But it is totally up to their discretion.

If they rule against you, there is no formal right of appeal. You can talk to your own country's government, ask them to make diplomatic representations. If your own government decides to do so (they are under no obligation to do so), there is some chance they might change the US government's mind, but no guarantee.
Imports of grain from Canada?
And if you don't have a VR headset or a holographic projector you can just 3D print one!
> Shovels break, light bulbs burn out. Then you go buy another one, and there's a good chance it's better than the earlier one.

Not in my experience. Almost always the new ones are improved only in one respect: profitability. Generally this means they have used cheaper components, lowered the cost a bit, and made an inferior product. Ok. End of tangent.
Google Adds Nigerian Accent to Google Maps
> (Anyone who used a Sun keyboard for a considerable period time is familiar with this layout. I do not know if any other systems predated Sun in this regard.)

I believe the ASR33 may be the originator of Ctrl to the left of A:

https://www.bytecollector.com/images/asr-33_vcf_02.jpg

Other influential terminals such as the DEC VT series, and the ADM-3A also placed Ctrl along the home row (although on many of the DEC keyboards, there were two keys in the modern Caps Lock position - Ctrl to the left, and Caps Lock on the right).

Many early home computers had Ctrl in this position, including the Apple II and the original IBM PC.

The very first Sun workstation used a keyboard with the same layout as the DEC VT100, it then evolved into the more well known Sun layout, which later inspired the Happy Hacking Keyboard,
"We can teach vendors that this is a bad idea and they shouldn't do it, and (cross fingers) it might go away"
If Mozilla puts the work in and the vendors have to do is copy it, then they'll copy it like everything else they use. FLOSS makes the net go round.
I think your design taste is sound. But there are some constraints.

The VR/AR vendor market has largely collapsed into a few big players with vertical-integration ecosystem-capture dreams, so high-investment opaque monoliths is what's available. Valve's OpenVR apis being the biggest multi-vendor exception. And they're immature, in a complex and still-evolving design space, making it harder to abstract commonality. And gaming VR imposes strict performance constraints, so some paths may have little slack with which to pay some abstraction costs. So having vendor-specific monoliths, joined only at the top, could be the right choice. Any failure to have their javascript-level joining be flexibly mixable... seems regrettably traditional for browser apis, and I don't know the cultural background for that.

I've mixed Vive lighthouse and custom optical tracking, Vive and WMR and now drone HMDs, on linux. I took a custom browser-as-compositor stack. (But there's also the Vrui VR Toolkit.)
deogeo wrote:
> Is a car manufacturer going to take more risks because of low interest rates?

It seems possible. Vehicles change every year. The amount and ways they change must be affected by available funding, perceived risk, and probably lots of other factors. A lower interest loan could make a risky prototyping project more attractive.

Even if car companies were really stuck doing one thing, shareholders are not. If car companies produce a slow, steady profit, and other investments are producing higher profits on average, chaotically, people will divest from cars and invest in a diverse portfolio of chaos.

I agree with what seems like your point, though. I don't understand propping up markets and businesses in order to help people, when we could just help people.
Massive social engineering mean the IRS would need every financial and legal transaction you've ever participated in. Which they clearly do not.

For example, we don't have a simple tax system based on a percentage of salary. The amount they want as a tax depends on your marital status, how many kids, how much your spouse earns, and if you itemize deductions it gets even worse WRT every medical provider's bill you've ever paid and weird details of interest payments on mortgage loans.

Honestly the error rate of trying to gather all that big brother data is almost certain to be higher than the fraud rate of people in general.

Also people push agendas, so if you want to spread the idea that fraud is rampant, if I get free coffee at church and starbucks has proven 52 coffees per year is about five hundred bucks, not declaring that coffee as income is fraud; with paper money and barter the IRS can't get all "weird" about little details, but with digital currency if you buy a donut, there will be a reckoning simply because its possible.
Ask HN: Messaging and content moderation in a social app
I'm working through a paper idea for a social scheduling app. The question I have is as a solo developer, should I include messaging if I'm unable to moderate the content due to time restraints, and unable to afford content moderation via third party service.

I'm thinking of including canned phrases to fulfill things like "I'm running late" or "Let's reschedule" as a substitute, is that going to be enough?
We can't even commit to private repos of the company we work for! this puts our job security in danger!! even if you or the company is not in Iran!!!
Also https://www.serverhunter.com
Is there anywhere except MyFonts to buy a license? The website is incredibly frustrating, it takes upwards of 20 seconds to do anything, and it's not clear to me how I can actually check out.

I still can't get the checkout page to actually appear, it just waits forever (but there's no loading spinner, so I guess it's some huge script running on every page load?)

P.S. It's nice to see a full set of basic Cyrillic and Hellenic characters.
How+Kola+Tubosun+and+his+team+gave+Google+a+Nigerian+accent
>> We avoid deflation because it incentivises hoarding currency over productive activity.

No, it incentivises reasonable spending on things you need and saving the rest over mindlessly throwing money on useless crap because your money lose value every day.
Right? Roborock S5 is a solid device. And most devices (Walmart and Target and everywhere else) are also manufactured in China.
I mean, they are engineered to have diabetes, I don't know if they have much cause to celebrate.
> Certainly, with that attitude. Personally, I fight that mentality when I can. The reason to lean on technology that is used in multiple disciplines is to increase the pool of viable programmers. If it's the wrong tool, then it's the wrong tool. But otherwise use the tool that the most can use.

Which is my point, the right tool in that case is one that fit on the memory footprint of an embedded microcontroler.

> On porting libraries...well, the WebSockets client I play with is only 60 lines.

Theses 60 lines does almost nothing. You ignore the 240 lines inside protocol.py just beside. You also ignore the 600 KB binary required for MicroPython. Already you simply CAN'T run on an ESP8266 that's only embedded with 512 KB (so can't be run on any of my ESP-01 module).

That does make me think though that the Websocket protocol is quite simpler than I though, but if I were to use it, I would plainly do a socket connection instead which would be even more simple.

> I use the D1 mini :)

Sure with one big enough, but we are talking about embedded, where resources are scarce. Running Micropython is a luxury for many embedded developers.
Have only and exactly the controls you want on your touchbar: https://community.folivora.ai/t/goldenchaos-btt-a-complete-t...
Pity, it's one of the worst aspects of the movie.

Why not simply that the machines are programmed to preserve humans, and that's the most efficient way they had to perform the task? Sort of clipboard factory, but with human life as the constraint.
I love your statement "the lack of steel causes a car factory to stop". You might not realize this but there is a lovely pair of articles comparing the approaches of genetics and biochemistry to understanding how car factories make cars.
http://www2.biology.ualberta.ca/locke.hp/dougandbill.htm

The more biology you learn, the cleverer the jokes get:

"""Emboldened by his successes, the next morning the geneticist tied of the hands of an individual dressed in a suit and carrying a briefcase in one hand and a laser pointer in the other (he was a vice president). That evening the geneticist, and Doug (although he would not openly admit it), anxiously awaited to see the effect on the cars. They speculated that the effect might be so great as to prevent the production of the cars entirely. To their surprise, however, that afternoon the cars rolled off the assembly line with no discemible effect.

The two scientists conversed late into the evening about the implications of this result. The geneticist, always having had a dislike for men in suits, concluded that the vice president sat around drinking coffee all day (much like geneticists) and had no role in the production of the automobiles. Doug, however, held the view that there was more than one vice president so that if one was unable to perform, others could take over his duties."""

(in biology, many processes have redundant components)
> you could get that information but you don't have access to the memory addresses unless you crack the firmware.

Correct, from the moment the IoT device puts a packet on the line, it is encrypted end to end. This is a fundamental aspect of TLS to prevent snooping. To view unencrypted data, you have to access it prior to being sent out on the network which requires you to gain root privileges on the IoT device.
Negative, US passports don't have fingerprints (in the chip).
Well, very broadly speaking there are two ways of looking at things. One philosophy is we should live in a world where the playing field is leveled and we should look out for the weak.

Another is the weak need to get out of the way of the strong, and if you are struggling, it is your responsibility to become stronger.

Increasingly I feel personal philosophies are largely self-serving. You believe in things that will benefit you. As you gain strength in one area, you tend more towards the second philosophy.

However, I think believing that can easily turn people into bullies. Do we want a society that is optimized for the dominance of the few? Do we want to break every interaction down crudely into a competition between "the strong" and "the weak," despite the fact that human beings are complicated and are strong and weak in many different areas?

The mistake a lot of meatheads make is assuming because they have physical strength, they should be allowed to dominate. However, in modern society, I feel other forms of strength are much more important. Emotional strength. Moral strength. Intellectual strength. They don't have much to do with muscle size, despite what some seem to believe. We should respect character more and physical appearance less.

I'm actually gaining weight pretty quickly now after weight lifting, but I hope I never forget what it feels like to be pushed around, and I never let myself push around others.
Too little, too late. Already switched off of Apple.
https://www.theverge.com/2015/1/5/7495073/msi-mechanical-key...

Just to give you a sense of what you're asking for.
> People shouldn't be surprised that SOOO much money is sloshing around looking for increasingly risky returns

Surely investors demand an interest rate that is higher than the risk. Gross simplification: their actual expected return is the difference between the sticker rate and the risk e.g. if risk of default is 2%, that sets lower limit on interest rate. If investor seeks return of 5% return then interest rate needs to be 7% (simplification).

So saying investors are seeking more risk has no meaning to me. Saying investors are willing to accept lower returns for the same risk makes sense.

Can someone with investment experience say that more clearly?
If I lost GitHub access I'd lose access to a couple dozen gists, certain branches I decided I didn't need locally any longer, and certain repos I started years ago and never felt the need to re-clone when I upgraded computers.

Github is not a backup service, but I can reasonably see how he doesn't have copies of everything locally
mddhosting.com
Compositing may be hard to judge, but crappy gamma-incorrect zoom (same problem) is visible everywhere.

Did you ever notice how the brightness of a zoomed-out photographs suddenly changes? Look for images with fine high-contrast structures, like brightly lit branches or distant fences. For example https://en.wikipedia.org/wiki/Crown_(botany) - see how the picture gets brighter as it de-blurs? This is not intentional. More often a region is just a bit too dark.

Same with thin line art. Zoomed-out cross-hatching is the worst-case. When you do inking on a PC you may only work zoomed-out, so you can print later in much higher resolution. Once you look at the print, the emphasis is all wrong. Some lines disappear while others are much too strong. You are about to complain to the printer but zoom in to check and notice that the print was flawless.

Some older programs (e.g. feh) switch to nearest-neighbour interpolation while you are panning. This looks crappy but actually gives you the correct average brightness (because it doesn't do any color compositing). You can see the brightness jump back to incorrect values when panning stops.
This is not bad advice, especially for people lacking the fundamentals, but these books are often way out of date and only cover topics that have been solidly established 20 years ago.

I would suggest, especially for people interested in a relatively niche field like aging, that a good compromise is to read review articles. You can go to PubMed and filter by review articles to find them.

But I wholeheartedly concur that for non-experts to read primary research articles will cause much more confusion than clarity. And doubly so for press releases on those articles.
I was expecting to laugh at how ugly it is, but it actually looks really nice! I bought the essentials pack to replace operator mono, which I've become bored with. Good job!

Edit: It looks really great with a theme that supports italics: https://imgur.com/a/VYH1J8s
Europe's record heat wave moves toward Greenland
> The IRS on the other hand with these kinds of notices is not out to get you.

Citation needed. The IRS can be among the most vicious of any federal agency. Having dealt with FATCA situations with overseas Americans, Treasury is, in my experience, nobody’s friend.
Yes. They succeeded so well people are still fixating on it 20 years later. When you need to make up an irrelevant detail it's better not to draw unnecessary attention to it by making it obviously stupid.
I'm happy about it, if only because it finally got me to adopt mapping CAPS to Esc, which is glorious.
Good luck dealing with any US based company on this. Tech companies hands are tied here, the risk of not following through is being literally tried for treason.
> I do live and work in Finland

So, they are blocking based on nationality rather than on location? How do they determine a user's nationality?

Do ITAR laws really require blocking a nationality regardless of their physical location? Would an Iranian living in the U.S. also be blocked?
Great response, really clear and simple
The digital economy is predicated on actual users and actual ad impressions --- the growth and effectiveness of both have proven to be grossly misrepresented.

That's the bubble which is in imminent danger of popping, and at some point, it will.
My Hardest Bug
Those are compelling reasons to take a larger look. I found charts tracking median household income by race, skip to part 3:

https://apps.urban.org/features/wealth-inequality-charts/

Seems hispanic and black families are both experiencing below average gains.
Or even play/pause buttons
Gut-Driven Development
The interviews are quite interesting.
Everything synergizes with "The Cloud". When you die, everything about you lives on in the great heavenly cloud.
Which I now regret saying as it seems to have been taken as a curmudgeonly dissing of 'yoof' in general. I never meant it thus. I was quite careful with my words, but not careful enough apparently.
Eve Was Created from Adam's Penis Not Rib: Bible Scholar (2015)
Trump threatens tariffs against 'foolish' Macron
https://www.bbc.com/news/world-us-canada-49131301
I've learned that when I actually implement a process (and not just call from a library), that's when the idea really "clicks." Usually it's much simpler than I realized.

I think it has to do with how, in programming, everything can be decomposed to concrete terms. If something seems vague, then it's possible to follow the execution of the code to find out what is actually happening.

Written formulas can be very ambiguous. I get the feeling that authors prefer to leave out as much info as they can get away with just for the sake of having the formula look "elegant." Many times, it's assumed you know enough to fill in the gaps, and it can be frustrating when you don't know where to even find that info in the first place.
> Like, you think that it's false, or you take umbrage to it being brought up?

Neither. I'm just not interested in unsubstantiated personal opinions. So the author doesn't like tattoos but decided to write an article anyway? Why? That people are generally shallow is an observation that can be made about a number of topics and I don't see what is gained when singling out tattooed people. Subcultures do tend to look ridiculous to the outsider.

The fact that people get tattoos to look nice in the eyes of other people who appreciate it was not discussed seriously in what feels like willful ignorance on part of the author. Or in the words of a tattooed friend: "People with a stick up their ass do tend to leave you alone once you've got your face done."

> Anyone with a nice tattoo will lament the fact that it will fade, it will lose crisp lines, and it will look bad over time.

That's not a novel observation for me. What's subtle or funny about it? "Look at these people. They think they have a nice tattoo but watch them in twenty years!" (I know it's not funny anymore once it's bluntly stated anyway, but I'm having trouble understanding how the original can be considered funny.)
I haven’t seen any plugs yet for AWS Lighthouse. It’s in a dedicated UI, so it’s not as overwhelming as AWS. You don’t need Ground Control satellite services to run a website.

Lighthouse starts at $5/Mo and comes with great docs and lots of templates. It’s pretty comparable to a Digital Ocean droplet.
I don’t know anything about rules ghat might control blocking of accounts but, in general, US export regulations do say that conveying technology to a foreign citizen even face to face in the US is an “export”. The term for this concept is “deemed export”.
This is exactly what I was looking for, thank you! If I get one of these I may call their hotline and ask them to clarify how airdrops should work.
Where are you seeing that? Ctrl+F for "Finland" doesn't return anything for me in this article, but I do see this:

> I am a software developer based in Iran

as well as:

> I know that I’m a resident of the sanctioned country
Reddit's UX was perfect from a (my) user point of view in like 2011. Everything added or changed since then has been either unnecessary stuff that nobody asked for, adding social network features that aren't what reddit was originally meant for, or a way to better serve ads.

The only thing reddit needed was to improve the mobile experience, which they kinda did, except they have tons of annoying dark patterns in it to push you towards the app.
I'm on the other end of this spectrum. I don't even click my trackpad, just use the very lightest of feather touches. I think the setting is called "Tap to click," and people that have problems with brushing up against their trackpad should not attempt it.
Both The Matrix and Inception are very thin from the philosophical point of view. The difference between the two is that The Matrix was visually gorgeous and innovative, while Inception is just another blockbuster.
I wrote this on Quora several years ago, answering the questions of why pixels are square (and quickly clarified that I interpreted it as "why are they laid out on a rectangular grid?"): https://www.quora.com/Why-are-computer-pixels-square/answer/...

The more I've thought about it since, the more I think we should represent images with hexagonal pixels (i.e., laid out on a hex grid), and that color images should treat the center points of red, green, and blue subpixels as not being right on top of each other. (the third image in the post shows how they would be arranged, which is actually similar to how they are on some displays)

It would be a little harder to deal with for graphics programmers who are working at a pixel level, or at the least, it would require a bit of relearning. But it makes more sense in so many ways. Hex is just a better way of "circle packing" (as you notice if you arrange a bunch of pennies on a table), and of course real world displays tend to have the red, green and blue subpixels offset from one another anyway. (are there any that don't?)

Obviously it isn't easy to change something like this at this point, but still, I find the idea fascinating, and appealing to the OCD efficiency fan in me.
Is the intense background noise of that video part of some inside joke?
If you go to System Preferences > Keyboard, you can change the "Touch Bar shows" option from "App Controls" to "Expanded Control Strip" to have the default set of buttons showing all the time.