skysight-inc/HackerNews huggingface dataset:
The most important part of CRISPR (Cas9) is its ability to colocalize with specific, arbitrary DNA sequences. It has a second function, which exists is many many other proteins and is not special at all - to cut double-stranded DNA. And in fact, that it cuts, is not actually desirable most of the time. Some of the most interesting uses of Cas9 actually try to get rid of its ability to cut the DNA (while retaining its ability to home in on specific DNA sequences).

I'm all for metaphors, but don't be afraid to shift them around when you think of a better one. (and 'malware' is not a better one...)
- Buckminster Fuller, 1981: https://freshairarchive.org/segments/bucky-fuller-humanitys-...
Billionaire and Facebook Board Member Peter Thiel Attacks Google
Interesting, it didn't add anything to my watch history on Safari; is this a browser thing?
Yeah, it's just dumb, pseudo-paranoid thinking. Crawlers are going to get it anyway, and it's publicly available, so why not make it easier for everyone?

And like I said, our biggest customer was our own company. It saved an incredible amount of hassle.
lol you support an article that includes the following:

"consider the ethical implications of virtual insects, including insect brain “uploads” and insect-like artificial intelligences that will emerge in the next few decades."
It’s not expressly design for that purpose - but censored search engines, search engines that report searches, software designed to spy on everyone, routers that intercept and report content people read, software managing concentration camps, etc all would.

Much like the numerous suits against IBM for supporting the holocaust and the gratuitous human rights abuses in South Africa. Most of which were dropped due to the threats of delaying payments or the amount of time passed.

The only way to stop companies from supporting human rights abuses is to remove their revenues from such. Google has demonstrated that given the choice it will happily support human rights abuses, while making use of the resources available in the US due to the existence of the constitution.
"you don’t see that much responsibility placed in such junior people anymore"

Sure you do, typically in new industries, like internet companies today, or space in the 60s.

Eventually the unicorns will be manned by aging suits, and JavaScript will be the new Cobol, and the hip young things will think vowels in names are actually kinda cool.
After reading "Why We Sleep" I've been led to believe it really ought to be just socially acceptable to consume this drug. Unless we challenge the culture of working early then it seems to be the case that many of us are physiologically dependent on caffeine because our work culture demands it.

Or we could fix the culture problem.
You do not have to answer, but if you do not, I presume the state, under the interpretation it has made of the law, can use your refusal as a basis for refusing your request for public records.
Sounds like a bug we hit at AWS a while back. The clocks on several of our instances started running at incorrect speeds. One was gaining something like 10 seconds every minute or something ridiculous like that. The rate was steady, just very far off from one minute per minute.

The Linux timekeeping system can normally deal with a clock that is steady but not the right rate by learning what correction to apply, but these were far enough off to be well beyond the maximum correction.

This only affected particular instance types, so changing to a non-affect type could fix it, but all the working types were more expensive than the types we were using which was annoying. Sometimes you could change to a working type then back to the buggy type and end up with one that did not have the problem.

There were a few people asking about this in the support forums, but apparently it was only hitting cheapskates like us who had not paid extra for support. Finally, someone paid for incident support and opened a ticket and Amazon quickly found and fixed the problem.
Its really expensive to have people sitting on death row?
not really, the evil is in the details, as far as I know, while there are many members listed, the China ones are the real ones paying a _lot_ for this and are the (probably only) ones really serious about this.
> You can also use cryptography in order to prevent spoofing.

I think that's probably the biggest selling point given how many important infrastructures rely heavily on GPS these days.
Ask HN: Is the Startup School Website Down?
At https://www.startupschool.org/ I get a 500 error. Is anyone else seeing this?
I'm surprised no one else has said it yet, but isn't, "We are going to make this environment more like a Google office," just the 20-teens version of, "No one ever got fired for buying IBM?" It was also what the article terms, "Lazy management thinking." It's imitating the surface level of big company success, without analyzing the how and why, and seeing if the cost/benefit factors also work out for yourself.
Recursion just gives you a stack data structure by letting you use the call stack. If you have a stack data structure to use explicitly, then recursion doesn't give you anything and takes away the simplicity of being able to see the entire state of the traversal easily since the call stack and traversal state are now intertwined.

You can just take the variables you are passing to each recursive call, put them in a struct, and make a stack of those structs.
Then... don't participate?
The Battle to Separate Safa and Marwa
"what's wrong with people spending money on things they want?"

It depends on what they're buying. Many people would consider unethical the buying of children or child pornography, for instance. Bans on ivory, whaling, and trading in endangered species have gained ground in recent years.

Some arguments for what's wrong with those are that the former exploit people who are unable to defend themselves or even realize they're being exploited, while the latter cost the lives of sentient creatures and reduce biodiversity by causing extinctions. Now, whether you find any of those arguments persuasive depends on your own values. Some people see nothing wrong with exploitation or species extinction. It's really difficult to argue against them. Either you share certain fundamental values with the rest of us or you don't.

Philosophers study such ethical issues in nauseating detail, but I've yet to see how any of their arguments would be persuasive to someone who doesn't already share their core values.
It seems clear that theories of software should continue to develop this level of formalism if we ever hope to trust it with our lives (eg software-piloted automobiles, safety mechanisms, nuclear technology, etc).

Imagine if car manufacturers had formal proofs of their claims regarding self-driving car software and it’s predictability / reliability. This is not a situation for trial-by-error.
I don't think GP is referring to Churchill's drinking. Instead I think it is more so about his crassness and racist tendencies.
AirVisual Earth – 3D Real-Time Air Poluttion Map
This raised the question in my mind: is the author being dishonest, or does he just have a different perspective and different values than me? Or alternately, have I not thought through my own values sufficiently to see that I should expect the same outcome as he does?

If I assume the author is being honest, the rationale must be something like this. The Chinese government is a serial human-rights violator. Most recently, it has been known to put people into reeducation camps on the basis of having a minority religious affiliation, but that's just one of many examples. Companies ought not sell to or provide services for human rights violators. This restriction should apply transitively as much as is reasonably possible.

Now, given that there is a company in this foundation that is working with the Chinese government, it is reasonable to anticipate that the efforts of the foundation would benefit the Chinese government. Therefore, all of the other companies that are participating in the foundation are tainted by transitivity. They should either oust the one company working with China, or else themselves leave the foundation.

I'm not sure where my agreement with this author breaks down, but it is somewhere before his conclusion. For me, the big question is how open standards and software jive with this transitive interpretation of moral responsibility. Anyone working on OpenCV or TensorFlow is working on something that could reasonably be anticipated to assist the Chinese government in the repression of its citizens. Same goes for anyone who publishes in the ML space. But I think the idea that one should not do these things is absurd, so I think a line needs to be drawn somewhere, and that line is far short of Google's or IBM's participation in this foundation.

That said, I think I could be convinced that companies working mainly with the Chinese government should not be allowed to sit on the foundation. But I'm not sure even of that.
Apple reluctant to push privacy regulation despite company focus
MS certainly is playing the game, so is Apple, Google, etc.

Still the market is what it is and I'd rather the schools follow it for the most part rather than try to lead, partly because schools are not qualified to make these decisions.
When I type "Donald Trump R" (or Ru or Russ etc) no autocomplete results contain the word Russia despite plenty of news coverage. When I type "Donald Trump Epstein" no autocomplete results. Must be a conspiracy by google to protect the president... or drawing conclusions based on individually cherry-picked autocomplete results is like drawing conclusions from numerology.
>why are they still charging insane prices for their SSD upgrades?

The answer to "why are they charging this much for so and so" is always "because a sufficient number of people are willing to pay it."
Don't donate canned goods to food banks (2017)
Why would you expect “brad Pitt email” to be something that auto completes? You would, on the other hand expect “Hillary Clinton email” to auto complete because there was a huge controversy about it.

I’m not saying google is manipulating auto complete intentionally (though they might be), I’m just saying your counter examples are irrelevant.

It would be like “Donald trump Russia” NOT auto completing then someone saying “but neither does Taylor swift Russia, so we’re good.”
Touch Bar, no... but Touch ID?
Also what the name of the startup :) hahaha
Regarding illegal execution drugs, John Oliver did a segment on lethal injections:

https://www.youtube.com/watch?v=0lTczPEG8iI

tl;dw: No physician worth his/her salt will go anywhere near prescribing drugs for lethal injection (Hippocratic Oath and what not) so states and prisons use non-medical-trained personnel to choose, source, and administer the drugs.
That is nonsense. Individuals choose where they want to work, not countries. And free markets eventually outperform non-free and corrupt ones.
After I registered my new car in Colorado, I started getting a ton of mail from fake car warranty scams. I called them a few times to stop mailing this crap, but they just kept going anyways. It was an address I only stayed at very temporary, and the DMV was one of the only places that I gave that address, so I am pretty sure they are doing the same thing.
There is Allegiant, which has an all-Airbus fleet, but you're unlikely to fly them unless you're taking a vacation to Vegas or Florida.

Spirit also gets an unnecessarily bad rap. Yes, their seats are tight, but they fly very few true long-haul flights, so it's not that big of a deal, and the Big Front Seat is probably the best value "premium economy" experience in the US. Prices for food and drinks in flight are more reasonable than they would be in the airport. In my experience, the only really unpleasant things about flying Spirit are:

1. Long lines to check bags (solution: don't check a bag, just pay the $5 extra to carry it on)

2. Other passengers that disregard plane etiquette (listening to music without headphones, etc.) or just complain a lot.
A word to the wise, don’t attempt to read this website on your phone.
I can't think of any technological advance that was achieved primarily through the effort of a single individual - in retrospect, it seems "obvious" that the fundamental principles had been in place and that it "only" took someone to come along and put them together in a new way.

I'm a firearms enthusiast and have spent some time studying the development of small arms. If transported back to the late 18th Century, I could explain and document the mechanism for an automatic rifle suitable for use by infantry like an AR or AK - but I likely could not produce one, and certainly could not produce them on an industrial scale. The metallurgy simply wasn't up to the task, nor was the machinery of the day. The metallic cartridge would't even make a lot of sense; as the percussion cap hadn't yet been invented. Even a manually-operated mounted Gatling gun wouldn't be possible without it.

Once a stable, impact-sensitive explosive suitable for use as a primer was invented, everything was in place for the invention of the metallic cartridge - and that's exactly what happened. Metallic cartridges lead to breech-loading firearms, which lead to the bolt action, which in turn lead to automatic and then semi-automatic actions. Neither of the last two made much sense until the invention and adoption of smokeless powder, as traditional gunpowder leaves so much residue that it would only work for a few shots before "fouling".

All that said, there are individuals that push the state of the art forward a great deal through their contributions. John Moses Browning, for instance. He created the first gas-operated machinegun and several of his designs remain in use (essentially unchanged) by major militaries around the world more than a century later.
I like fast SSD's as much as everyone else, but it's not like those disks are a slouch. 1.3 GB/s is still plenty fast, especially for those who are in the market for the Macbook Air.

It's probably however the first time, I can remember at least, where Apple downgraded a newer model in such an unequivocal way.

I mean newer CPU's have had different multicore/single core tradeoffs, the inclusion of a dedicated GPU have been removed in base models etc, and the endless discussion of ports (rip SD card slot etc) but I don't think we have ever seen something like this?
I just bought a 1TB NVMe PCIe SSD for $110.00 off Amazon. It's about 1Gbit/sec slower than the next price point but it's about 2 or 3 times as fast as my existing SATA SSD.

The next-highest price point was a 3Gbit/sec 1TB SSD for about $150.00.
I would love to know what hateful opinions Stephen Hawking held?
People on Reddit wanted him on the £10 notes instead.

Makes sense to have ones and zeros for the father of electric computers...
So it should be easy for you to find sources.

Life Expectancy in the US is going down [1]. That's happening as many people are living longer than ever. The difference comes from plummeting life expectancies at the bottom.

Real minimum wages peaked in the 1980's [2]

Calling obesity "self caused" is unreasonable. Access to food, particularly for poor people is very different today than at any time in the past, Malnutrition is totally possible alongside sufficient caloric intake.

Why is the cost of "luxury goods" relevant to anything?

[1] https://edition.cnn.com/2017/12/21/health/us-life-expectancy...

[2] https://www.visualcapitalist.com/visualizing-real-value-u-s-...
It is roughly 1.15^(365*20). That it is wrong was clear from its size. I wanted to use it's falseness to show that the assumptions are incorrect. Which they are, just not how I understood initially.
Thanks!

As someone who's planning on leaving a FAANG that starts with A and ends with N/M/R ;)

I'm more than aware of what it's like to be brazenly mismanaged and taken advantage of. Not really where I wanted this thread to go, but has to do with being involved as a NCG at a company recently acquired by aforementioned FAANG.
33.5 million IP addresses is no small drop in the bucket though!
It reminds me of the Adult Swim show "Robot Chicken". Not exactly in content but in format and style. Just random things, slices of life, from people across the world.
Same. Just bought first Windows laptop in 11 years: Thinkpad Carbon.
Wouldn't blocking stuff using AWS block like, a significant chunk of the internet?
https://www.poetryfoundation.org/poems/46560/dulce-et-decoru...

I don't know how 10-year-old me found that poem, but I memorized it for a fifth-grade poetry recital. Dulce et decorum est pro patria mori, indeed.
zkPoD: A decentralized system for perfect fair data exchange
Here is a clickable link: https://www.startupschool.org/
I wonder about the low level labor in data centers. Swapping disks and servers. I imagine they have a lot of the same tracked-time-pressure that retail pickers do? But I've never read about it one way or the other either.
You're absolutely right to focus on making sure we know how to deal with these things. The difference is that there aren't two sides to a tornado. We should also additionally focus on the people and systems that make this happen.
I've been listening to "13 minutes to the Moon" from the BBC recently. https://www.bbc.com/news/science-environment-48232627

One part jumped out at me as brilliant especially for the time: when the computer was overloaded with tasks during the decent, it switched off all non-essential extras like screen displays in order to free up processing power. After that it shed even more to focus on only plotting the landing!
> he had hateful, controversial political opinions.

Could you point me towards some more info please, I was entirely unaware of this.
Learning Key-Value Store Design
Churchill did more good than bad.
"Competitive bid doesn't have to mean lowest bidder"

No you have to wine and dine the right people, and line a job up for them when they retire.
I very much agree with that in terms of the old 777-200(ER) and 777-300(ER).
The upcoming 777-8 and -9 don't fill me with confidence though.
Speed of SSDs depend largely on number of NAND die and NAND technology. As they shrink the transistor size, they leak and interact more so it becomes a little less reliable (unless improve the error correction to compensate.) Smaller size means capacity per die increases so fewer NAND die to get target capacity. The main way to get performance on SSDs is to run the NAND die in parallel. With fewer dies, the performance drops. So you can increase the number of die and thus keep performance the same while increasing the capacity. But the likely went to first route to save money.
It's a really good podcast, but I found it a bit bloated in places, I could have done without the Hans Zimmer theme, of which they are so inordinately proud.
This was really interesting. I've always viewed the Wrights as "hobbyists" or "tinkerers" - but now I'm going to have to do some research on their lives. If the impression I got from that article is remotely accurate, they were engineers. It seems almost insulting to call them "bicycle makers".
Why the 10x Engineer Myth Needs to Die
You're comparing the mortality rate of automobile travel to that of aircraft travel. Would you also compare the rates at which the two forms of travel are subject to, say, bird collisions?

Comparing the two is drawing a false equivalence. Yes, flying and driving are both modes of transportation, but they're radically different in terms of methodology.
There are plenty of videos without that format. Those titles are just sequential file names of many cameras.
I'd likely choose the BMW, but sounds like great driving indeed!
I'd be of the opinion that anyone who uses expense as a justification here is less morally balanced than most of the people on death row.
For #1 I'd prefer if Google didnt share my search history with anyone. That would also go against GDPR in Europe right?
Improving heat recycling with the thermodiffusion effect
Microservices...because scalability...that you'll never need.
It allows data exchange between untrusted parties realizing "Payment on Delivery" without any trusted third party, which is a further step after Bitcoin realizing "money transfers without intermediaries".

I hope to see more stuff come about that connecting blockchain with the real world.
I get such a kick out of watching you guys beat up on JavaScript. I mean really, what could be further from this topic, and yet here we are!
I've worked for and know many people that work for very large (F500ish) companies, as well as the large consulting companies (Deloitte, Pwc, Accenture, etc), and booking your own flights/hotel is standard practice at all of the consulting companies and most of the others.
I’ll second that. I particularly liked the part on home the memory worked
That's not the point. The people that celebrate him now hated him so much in the past that they have driven him to suicide.
I'm skeptical of the $1.90 a day number. Those people would be dead. You literally cannot buy enough food to eat with that much money. Since we generally don't see millions of people dying of starvation in the U.S., some part of the equation must be missing.
That's interesting to me, because this is the first product they've offered in awhile that could have drawn me back. The return of actual function keys being the biggest draw.

Unfortunately for Apple, my Mid-2012 MBP didn't last long enough for them to get their proverbial scat together and I'm running Linux on non-Apple hardware now.
I respect your opinion and would respect your decision. Although would not stop looking for funding elsewhere. Even a failure in such endeavors gives a great return on investment. Many modern tech wonders are a direct result of space research. Humanity has to be a space faring civilization, else our future generations will go extinct. Imagine if our ancestors had stopped exploring the oceans until all of humanity's problems were solved.
Oh yeah, like I said any changes in operational characteristics are incidental to the most important bit: reduction in cost.
But the Airbuses were not grounded right? It is a different thing when they end up grounding all planes of a given model...
The latter is rarely effective for a small company imo and is way more of a dangerous cargo cult in my experience. It's like trying to swim while wearing shackles.

One principle I think about when refactoring, is reversibility. If something turns out to be wrong, can you change your mind with minimal cost? To generalize, when trying something, can it be tried and backed out for minimal cost, while providing good information?

I also always find it weird how nobody picks other giant companies to emulate, nobody's like "Well JP Morgan has great employee mortgage rates!" or whatever.

For the answer, I think one can analyze their marketing and how the culture once perceived SV and the startup scene.
Switzerland. They’re talking about 1000 CHF (Swiss Franc) notes.
Let's not forget the exploding batteries which were fixed by putting a metal container around them and a hole in the hull, so when they inevitably explode again, they'll at least vent outside.

It'd be okay with that shit on a bus. Not on a plane in the middle over the Pacific. How the 787 got it's ETOPS rating is beyond me.

(actually it isn't. We have all witnessed how corrupt the FAA is by outsourcing it's own job to Boeing itself - the equivalent of a professor outsourcing paper grading to students themselves).
I can only say Amazon India now sucks, the products aren't growing.

Neither you can buy screws, threaded rod, 2 part epoxy, MDF boards, there.

Not sure what Amazon India is selling exactly
Demo of a tiny game I made using Phaser and TypeScript (open source)