skysight-inc/HackerNews huggingface dataset:
For every new drug that starts in academia, a pharma has optimized that molecule / biological to maximize efficacy and reduce toxicity, always incurring major expense to do so, 90% of the time ending in failure.

Like most 'successes', new drugs arise due much more to grunt perspiration (and regulation) at a pharma, than due to inspiration by a genius inventor — despite what industry outsiders may want to believe.
My wife follows him on 4square, now Swarm. I wish he would eat at better restaurants so we might enjoy his company in the world longer.
If you don't mind me asking, what did you get the tethers for?
Hardly.

There are still DC-3's in commercial operation, and production of those ended in 1942.

http://www.buffaloairways.com/ is one operator.
Serious question. What is the reason for holding Tethers?

They a supposedly pinned to the dollar, so there isn't much point in holding them hoping they will gain in value. If anything their peg is questionable so they are only likely to decrease in value.

As far as I can see their only purpose is a a way of transferring between other crypto currencies and exchanges, but you would only ever need the tethers very short term while you completed the movement or transaction.
> I come from an environment where, if you see a snake, you kill it. At GM, if you see a snake, the first thing you do is go hire a consultant on snakes. Then you get a committee on snakes, and then you discuss it for a couple of years. The most likely course of action is — nothing. You figure, the snake hasn't bitten anybody yet, so you just let it crawl around on the factory floor. We need to build an environment where the first guy who sees the snake kills it.

I can't help but read this quote in Ross Perot's voice. Hilarious and illuminating at the same time.
There is, of course, a wide range of commercially available wireless ISP hardware, most of it made right there in China. It would be easy to set up many gigabit links.

But it’s very easy to detect and home in on radios and the government wouldn’t take kindly to it. Lasers have the advantage that they are hard to detect if you’re not in the beam.
I haven't used Pinboard but you're damn right about this. Is like the supermarket, one day you find chocolates in one isle next week chocolates are in a completely different isle only that messing around with the UI infuriates users.
You can be accurate and still be uncharitable. Educate, don’t chastise or mock. And never make it personal.
SSL certificates are typically issued for domains and aren't tied to a specific IP address. So you need a domain name, and clients need to be able to resolve that domain to your IP, which means the network needs a DNS server – but the DNS server itself doesn't have to be online at all times, it just has to know what IP to return for your domain. I am not sure how that works with your mesh setup.

Note that some domain validation methods involve the certificate authority resolving the domain to an IP address and trying to connect to it on the public Internet – but not all. Let's Encrypt, for example, supports the dns-01 method, which just requires a custom TXT record to be set on the domain. (But of course the TXT record itself needs to be on the public Internet.) That said, since your goal is to work offline, you may want to use a different CA that issues longer-lived SSL certificates, since Let's Encrypt only gives you 3 months at a time.
> I'd argue that HN doesn't require encrypted data transfer at all

It's still a good default, because it sets up a social expectation of privacy, which is very important in this era of data mining.
> Is it really more power-efficient?

I would expect huge difference for similar operations. Current-gen $300 GPU consumes 120W doing 4.6 TFlops. Current-gen $300 CPU consumes 65 W doing 16 flop/cycle * 3.6 GHz * 8 cores = 0.4 GFlops. GPU cores don't spend electricity minimizing latency e.g. predicting branches, and they work at much lower frequencies.

Also some parts of the pipeline are implemented in hardware (rasterizer, texture units, alpha blending, Z buffer), they don't cost flops and hardware implementation is likely even more efficient than shader cores. E.g. if you want a gradient, load/compute per-vertex colors and the rasterizer will interpolate in hardware.
I am still very skeptical of PoS. To my knowledge, no PoS system provided an adequate proof of correctness as of today.

Stellar is not trustless.

> ETH enabled a vast amount of scammers and BS artists.

I believe this is not relevant to a technical discussion.

You are probably right about Monero's limits in comparison to ZCash. But, TBH, I am not following their development, because I prefer lack of anonymity.
I recommend the google assistant skill [1] for your Alexa device.

I use it for asking questions I know Google will answer but Alexa probably won't. "Alexa, ask Google 'difference between chow mein and lo mein'"

[1] https://github.com/tartanguru/alexa-assistant
>> and for overall metallicity to become significant enough to allow for the formation of terrestrial planets.

You don't need much metallicity before terrestrial planets start forming. They would certainly be rarer in the early universe, but stars filter material very quickly (pushing light stuff further away, stripping new planets to their dense cores). So even with 10% of today's metallicity, there would still be plenty of terrestrial planets.

(lol. My spellcheck corrects "metallicity" to "Metallica".)
One of those seems a lot more powerful than the other...
Security is an essential social norm, because it reinforces the notion that, no, eavesdropping is not good, it is not acceptable, and we will not stand for it, regardless of the medium.
Show HN: Single Platform to Convert MySQL, PostgreSQL and MongoDB to RESTful API
I don't disagree with any of these points, just had a tangentially-related thought: wouldn't making college "free" be a forcing function to tighten admission criteria, further stratifying social classes? Schools can be a bit loose today since basically anyone with a pulse can get student loans.

Just thinking out loud; I suspect looking at other countries who do this would be informative...
Thanks. Usually thanks comments are in bad taste on HN but this reply, especially the last quote is very enlightening. There is overlap but "data" here is not merely state of an "object" (which itself is an entity of abstraction).
Oddly, that wasn't your claim.
Clinton campaigned on signing NAFTA. It wasn't just dumped on him.
French government, unlike German one, is a lot smarter, and didn't kill its nuclear industry, adding more coal burning emissions. Surely this will pay in the long term. And a lot.
Infections were not created by greedy farmers. They occur naturally among all animal populations.

Some quick googling indicates that this practice both increases meat production by 10-30%, and protects animals from a lot of suffering, as they spend their lives mostly healthy.

That said, yeah, we can't keep doing this, and we have to pay the cost. Let's just not pretend there is no cost.
>What I don't understand is why people don't band together and simply refuse, collectively, to pay bills that are well known in the culture to be unreasonable. In particular, student loans.

Or taxes, when they are being used to recklessly loan so much money.
The article says after being banned from doing business in New York, they opened up offshore shell companies to open accounts with NY banks, engaged accounting firms in NY, and dealt directly with NY based investors.

That is pretty solidly doing business in New York.
I wrote a hooking library that implements the methods talked about, plus a bunch more it doesn't. As well as handle a bunch of edge cases not mentioned: https://github.com/stevemk14ebr/PolyHook_2_0
Normally, charity in an interpretation means that there's a way that it could be taken where it makes sense. I don't think that's the case for this comment.

The most charitable interpretation I have is that the original poster is a paid shill -- in other words, they're bright enough to realize what they're saying is idiotic, but they're just doing a job to put food on the table. It'd take some evidence to sway me to that view.
I wish it allowed to install community extensions which are not part of core software.
Show HN: redis-protobuf: A Redis module reading and writing Protobuf messages
> The notion that some random app can just spin up a server on localhost without my permission is completely insane.

As far as I know any desktop app (userland code) can listen on a non-privileged port without permissions, on any desktop OS.

I’ve seen a few programs (like R) run web servers to provide documentation (although, the server only ran temporarily).
It is possible that the neutron emission number I found and used includes self shielding or is simply wrong. if the activity is 2.78e16 decays per second and not just 1.1e15/s then the decay heat would be about 30kW.

But to be honest I am not sure if it is worthwhile to keep fixing bugs in this estimate. We know several good reason why there is no 1.4kg of Californium anywhere.
USDT has a strong following in APAC countries. Also for some crypto users part of its allure is that it’s vaguely sketchy - it means they are less likely to have their funds blacklisted, a feature which Tether maintains the ability to do but has never enforced as far as I’m aware.

If you are getting into the space now USDC is an audited stablecoin backed by Coinbase and Circle which has the second highest issuance after Tether. Most likely you would prefer USDC over tether.

https://www.circle.com/en/usdc
LISPs have this idea so deeply etched into them that code itself is data - homoiconicity.

In the Clojure community, for example, you will find that the primacy of data is well understood and used. Data-Oriented design and all that. You'll see the aphorism "Data is the ultimate in late binding" mentioned.

You will also find that it is immutable data that reigns supreme.

Notice also how, in a reactive system, it is the data (or the arrival of it) that coordinates the functions/processing, not the other way around.

I was exposed to the "data first" (and non-OO) way of thinking about 5 years ago, after being in the OO world since the mid-80s. I haven't looked back. When the penny drops for you on this it is a profound and liberating moment (or at least it was for me).
Database and filesystem share a lot similarity, but still have their own characteristics. To use database as a back-end for filesystem has some benefits, such as reliable persistence, ACID transaction and etc. It reduces complexity to achieve durable storage which filesystem should deal with.

Many filesystems are able to use DB as back-end, I also made a filesystem ZboxFS (https://github.com/zboxfs/zbox) which can also use sqlite as underlying storage.
Something is off here.

Here is how you transport Californium-252

https://en.wikipedia.org/wiki/Californium#/media/File:CfShie...

A giant flask filled with polyethylene or water (lead won't work). That's for 1 gram only!

18 grams is just a ridiculous amount. I suspect it is not Californium-252 but another isotope (251?) or maybe not Californium at all.

But yeah it is the most expensive commercially produced substance currently. And smuggling it would make sense from that point of view. However being bombarded by deadly neutrons while handling it, probably ensures you won't be doing it for long.
THERE IS NOTHING LIKE NACHO ANALYTICS. THIS IS NOT GOOD. IF YOU KNOW OF AN ALTERNATIVE, I'D CERTAINLY LIKE TO HEAR IT!

NOTHING LIKE IT.
The storage is definitely not free, even while inactive.
I live in Corona California and an avid follower of Dutchsinse and his earthquake webcasts. I have the utmost respect for Dutch and for the support he provides on a daily basis 24/7 if he needs to. I as well as hundreds to thousands of people participate daily to be more attentive to events seismically and be prepared not scared. He has been attacked personally and ridiculed being labeled a fear monger! The information is utilized by data researching provided by the professional agencies. Dutch has our backs and provides me the knowledge to feel my safety and my family atleast have a chance of survival and what to look for. I am ashamed to say that my 57 years in california none of the agencies do anything for my safety concerns and I and many like myself feel the same way I trust Dutch and his crucial updates 1000% before considering what my officials status news conferences, broken earthquake alert app malfunctions(available Los Angeles residents only). 7.1 earthquake and Usgs site crashed and unavailable. I reside in Riverside county where shake app is not available. As far as fear-monger tactics Dutch is dedicated to what he does and is extremely gifted with having high school diploma. If you don't like what is being told to you and events surrounding you then go about your way and don't judge someone until you check it out and see his wonderful webcasts and how much he helps anybody who wants to see the truth of earth events. So Blessed to have found Michael Janitch aka DUTCHSINSE.
Base64 needs 64 unique characters, but domains names don't have 64 unique characters. Also base64 could result in pure numbers as its output, leading to the exact same problem.
When we ban established users, we tell them we're banning them and why. Shadowbanning is for new accounts that show signs of either spamming or trolling—especially serial trolling, i.e. someone we've banned before and whose new account indicates more of the same.
I was specifically thinking about Pindroid actually! It hasn't been updated in over two years. I had some weird issues where the back button of the share intent wouldn't correctly return me to the app I was sharing from, instead bringing me to my bookmarks. There were a few other little small things, but the fact that it's not being maintained anymore doesn't give me hope it'll ever be fixed.
Seems like Big Pharma would make more money selling the superior startup drug they now owned.
The reason is when you have some other crypto holding and you want to close out your position but not have any reportable tax or legal liability.

Of course you’re trading one set of liabilities and legal ramifications for a whole new set. Plus a hell of a lot of counter party risk.
I did assembly on 6502, 6809 family, and 68000 for quite a few years. While I did enjoy Tis-100 and other zachtronics titles, those are actually quite a bit more challenging than real assembly programming. In real assembly you’re pretty much never limited to like 1 or 2 bytes of ram to work with. Zachtronics games are more like puzzle games than a real taste of assembly. For a real taste of assembly, write a little game in real assembly, or maybe calculate Fibonacci numbers in 6809 assembly, or maybe play with Chip-8.
>>> "Children grow up aspiring to be Youtubers. Teenagers rake in thousands of dollars selling slime,"

No. They are not selling slime. They are selling themselves. Just like any hollywood starlet, they are marketing their youth and sex appeal. Customers buy a fantasy, a perceived connection with the attractive or famous person. If that makes the customer happy then that's great, but don't pretend that just anyone can start a youtube channel and start getting paid. Being young and attractive is 99% of the game.
It is certainly pretty. But I'm still not clear what it means.

OK, so the radar is measuring distance between the satellite and reflecting surface. They're compairing data from July 8, 2019 and April 8, 2018. I'm guessing that the two images look pretty much the same. Especially given limited spatial resolution.

But ELI5, what does the interference pattern show? I mean, are there 12 cm amplitude waves of vertical surface displacement? Something like frozen S waves?
At least in that case, its a matter of looking at the Amps to make sure there is enough juice.
Blown out of proportion. A real vulnerability I wish was handled more seriously. But at the same time, even after I “fixed” the vulnerability, my preference in Chrome to always open links for zoom, with zoom, made it nonsense. The problem is with lax browser security and CORS as a product “feature”.

It is worth underscoring that the only reason this vulnerability exists is because Safari forced appropriate prompts? Zoom hacked around it, and got away with it. That’s on browsers to fix.
Probably because it's fake news. This format pops up every once in a while, "The police seized x amount of y nuclear material worth z million dollars". It's usually Californium or phosphorus...

This is from the last year and even has photos: http://www.hurriyet.com.tr/gundem/ankarada-nukleer-madde-ope...

Does this look like a Californium to you?
I don't think that's all that relevant as a customer unless those SP&P 500 companies ending regularly involves their services being turned off suddenly without warning.

I imagine a lot of those companies ending is the result of acquisitions/mergers where the services continue uninterrupted and in the vast majority of cases where that isn't true, there's a warning that it will end.
Aside from being a saint, I think Woz singlehandedly jumpstarted the computer industry by 1-2 years with his genius early designs.

It would be 2017 now if it wasn't for him!
I have spent a lot of time with a lot of families from wildly varied economic backgrounds. I'm not talking about people with brand new cars and 3,500 square foot houses (that would be a McMansion, I believe). I'm talking about Hondas and weather-worn Dodge pickups parked at a condo or a very modest house in a working class neighborhood.

Sure, the keeping up with the Jones thing is happening with a lot of people. But that does not appear to be the bulk of the problem. Heck, just drive through the country and tell me if you spot more McMansions or more McShacks.
You left out the portion of the article that says only apps you built yourself don't need to be signed/notarized.

Apps distributed over the Internet, like, you know, the ones we're talking about, must be notarized according to your own source.
Ok. Take if from the maintainer of GPG:

https://lwn.net/Articles/464137/

Hint: TOFC is a lot like what I described above, with the added usability that you don't have to type "yes" every time like a chump.
Short term value and thinking.
> How much battery am I losing to this stuff?

Unless they coded something very stupidly, a listening socket that nobody connects to is not going to be on the CPU. It will be asleep waiting to be woken up by actual activity.

Not sure if any operating system would use that socket as a reason not to enter a low power state but I kind of doubt that.
There is no other way to buy yourself past traffic.
Qualitative Analysis of Cannabis Use Among Older Adults in Colorado
I would be interested to see how it compares with AWS EFS under a variety of load.

AWS EFS implements NFS 4.1 which support has support for massive parallel IO.

http://www.pnfs.com/
How does the regex work?
That's not a solution, it's just a contrapostive.

The solution is to change/improve the system that is creating the regulations. There will almost definitely be new regulations involved in doing this.

I don't see how a system that creates excessive regulation can be expected to constructively par down that regulation without significant changes to that system.
Fair enough. I'm in love, which perhaps blinds me.

Their Premium site gives a better gallery: https://ec-club.panasonic.jp/pc/premium/

And their colour/aesthetic customizations exceed anything I can find in the west: https://ec-club.panasonic.jp/pc/sp/customize_letsnote/

Panasonic has even had partnerships with e.g. Star Wars to have unique laptop-backing options, which is a bit wild for a business-series laptop.

But sadly they seem to have discontinued their best-looking and most interesting option: the MX. It was a 12.5" laptop with a rectangular touchpad (that had real buttons). It was a Yoga-style touchscreen (with stylus), and had all the ports you could want (e.g. vga, ethernet, SDcard). Just ~3lbs but also certified as semi-tough, and with good keyboard travel.

But then the killer feature: two batteries. One internal, but another one removable (yet still fits flush on the bottom when connected). When you remove that battery, you can charge it from the wall / by USB. That means you can hotswap your batteries and keep charging them -- infinite battery life!!

It's just so interesting to me. Such a creative engineering marvel, not even mentioning the circular touchpads they have on their other models. We don't see anything close to this in the west -- instead we are constantly complaining that our laptops keep losing features that we want. Why!?
It's fake news.

Here is the same "news" from the last year with pictures of the siezed Californium: http://www.hurriyet.com.tr/gundem/ankarada-nukleer-madde-ope...

This "news" pops up every once in awhile, it can be Californium but it can be some exotic phosphorus too. I guess it depends on the creative mood of the journalist.

I flagged this.
Me too! Especially when we know most services will eventually die, no matter it's Google+ or any trendy startup that will be acquired at some point.
It was. Read the OP's claims about Mars.

Mars alone does not provide the answer about whether or not life evolved independently in our solar system.
What part of Catalina still runs apps which haven’t been notarized or even signed, including those built after 1 June 2019. But you may find them more complex to run

Is difficult to understand? In Catalina just like in the current OS, there is a built in method for the end user to bypass code signing for any app. The user can choose to run unsigned third party code.

The article states that code you create doesn’t have to be signed and you don’t have to go through the “complex” process to run it.

Third party code forces you to go through the “complex” task of ctrl clucking.
Just for fun, here's my IEEE 754 implementation of double precision floating point for the 8088:

https://github.com/DigitalMars/dmc/blob/master/src/CORE16/DO...
You could check if they have a security.txt[1]. I don’t think it’s terribly common, but I know there are some out there.

[1] https://securitytxt.org/
The average hypothetical alternate history investor seems to have that kinda money.
I mainly blame the doctor for not testing for strep and the multiple times he was "convinced" it was something else without testing for it. Under no circumstances should a doctor say "I'm convinced you have HIV. The tests will confirm this".

Furthermore, penicillin is only suggested for group A strep, which has already been declining in effectiveness since the 80s. It also shouldn't be given simply as a precaution until you know what bacteria you're dealing with. It was probably already a resistant strain of strep, but the way the following doctor explained it to me was that by introducing the penicillin, it made it more resistant to other antibiotics that I should've taken instead. The only course of action I had was to wait it out. She said she could have tried other antiobiotics, but there was no way to tell if it would work. Luckily, I was already recovering by the time we got the results back for strep throat.

P.S. The person I contracted the strep throat from was fine after about a week of clindamycin.

EDIT: I’m no doctor myself. I’m just going based on what I was told. If the second doctor gave me bad information, then I’ll be happy to assume that both were shitty doctors. That wasn’t the only time I had horrible experiences with that clinic (completely forgot to document multiple doctor’s visits and weeks of PT I had in relation to a sports injury and I lost my redshirt eligibility as a result as there was no proof of the injury). That clinic was the only option I had with student-athlete health insurance. But, I’m not changing my mind on the first doctor after everything else, regardless of the penicillin.