skysight-inc/HackerNews huggingface dataset:
With respect to cancer drugs, while generally no one can be prescribed medication that has not passed clinical trials, in the case of terminal patients who could potentially be saved by a drug currently in trials, there is a system for allowing them access to the medication.

It's called "Expanded Access" (also known as "Compassionate Use") https://www.fda.gov/news-events/public-health-focus/expanded...

The other reason why data sharing is hard is because it costs on average over $1,000,000,000 (1 billion USD) and 10 years of time to whittle over 10,000 drug candidates into a single new FDA approved NME (new molecular entity).

If you spent a billion dollars and a decade on a project, you will consider the data you collected to be a trade secret and would protect it with everything you can, because you have to now take this drug to market and make up the billion you spent making this drug. If you simply shared all your results, foreign competitors will simply copy your work without paying you, and will then offer your product without the cost of R&D and regulation built in: AKA they will charge 1/10 or less than you and you will struggle to profit anywhere they are in the market.
I was a hands on stay at home parent. Kid still had a few tantrums. Every kid is different, you’ll probably observe that when your next arrives.
"And I am being downvoted for that. Interesting."

I downvoted you because you talked about your downvotes.

Please don't interrupt the discussion to meta-discuss the scoring system.
But that's the point. People in the comments here seem to think that the unlimited vacation policies are about guilting people into not using any vacation. While that may be a secondary effect, the primary reason is actually to remove unpaid vacation days as a liability from the books, since that's quite expensive especially with the increase in software engineering company salaries in the past decade.

Anecdotally I worked at VMware and Dropbox when they rolled out these policies. I took about the same vacation time as I had used previously and the difference was mainly that I wasn't owed any vacation money when I resigned.
It generally is standards based. Their customers demand it to be so. IPSec tunnel overlays, usually if not always full mesh. The non-standard part is tiny insignificant tweaks to IPSec that render it unacceptable to standards speaking endpoints, thus you can't coordinate with your open source IPSec device. Stupid myopia, because these systems depend on proprietary orchestration anyway.
No, I didn't misread. You and I are in (apparently violent) agreement. Constant time does not mean that running time cannot vary, in either complexity theory or cryptography. There are misconceptions on both sides here, with regard to what the terminology means in both complexity theory and cryptography.

For precision, I'll start with a good definition[1] for what "constant time" means in cryptography:

> Constant-time implementations are pieces of code that do not leak secret information through timing analysis. This is one of the two main ways to defeat timing attacks: since such attacks exploit differences in execution time that depend on secret elements, make it so that execution time does not depend on secret elements. Or, more precisely, that variations in execution time are not correlated with secret elements: execution time may still vary, but not in a way that can be traced back to any kind of value that you wish to keep secret, in particular (but not only) cryptographic keys.

Secure, constant time cryptographic algorithms need not have unvarying execution time. Now going back to complexity theory, it is also an extraordinarily common misconception that "constant time" means "the algorithm has the same execution time regardless of the size of the input." This is not the case. Big O notation doesn't even care about what always happens, it cares about what happens in the worst case. When we use "constant time" in the O(1) sense of the word, we are not precluding the possibility of an algorithm having variable execution time. Again, for precision, we are simply saying that the execution time (number of operations, etc) has an asymptotic upper bound which is independent of the input. The execution time may vary with the input, and generally speaking it will.

_________________________

1. Thomas Pornin, Why constant time crypto? https://bearssl.org/constanttime.html
Transparency, in all levels of government.

And quit equating money to speech. Lobbying is legalized bribery and everyone knows it.
A friend had these problems frequently and said that if it was a legal/contractual requirement, he would adhere to it to the letter. But if it was some out-of-touch boss's boss's boss that made an unrealistic demand, his inclination was to go with "how it was done".
Who's been sleeping in my bed? An unexpected guest
If you've got a site with decent levels of traffic host libraries yourself rather than use a JS CDN.

Retrieving critical content from a 3rd-party CDN has a number of issues:

- New TCP connection has to be created with added cost of TLS negotiation and it's own slow-start phase

- If you're using HTTP/2 then prioritisation only occurs over a single connection so it can't be prioritised against other content
how about “a phenotypically and statistically relevant portion of one’s DNA can be traced back to X region over the range of Y years ago”?

nobody is saying anything about “racial theory” in society at large. more so that certain particular phenotypes are strongly correlated together - like your example about Alzheimer’s.
Is the Windows Store a thing that people actually use? I'm broken by decades of Windows use, going back to 3.1 at this point, so I am completely conditioned to installing software off of disks (it's still a thing, I swear!) or downloading from a website. I also run Windows 10 LTSB on all my machines, so there is no Store available there.

The vast majority of the paid software I have consists of games that come from Steam or Gog. Steam really doesn't work well with UWP games, and the Gog stuff I have is mostly nicely packaged DosBox games from an earlier age.
Will a licensing model that mandates companies who have a certain amount of revenue to pay up for using the OSS, work?

Are there any licenses like this?
An open letter to Stewart Butterfield: Why Slack will never replace email
Reading the article and the comments prompted me to wonder what would happen if//when I say something to the order of "may I read it first?". As I age, I feel myself becoming more cautious than I was [perhaps as cautious as I should have been in the first place a la "everyone agrees to the EULA"].
Here is one example

https://ivn.us/2013/02/11/the-revolving-door-fda-and-the-mon...
> the parts in the middle usually have no idea what to do with “exceptional” reports that cross their desks

Or they explicitly don't want to report them because it makes it look like they don't know what they are doing, or they are afraid that it would create more work for them and they are already overworked.
magnet:?xt=urn:btih:F046266BE1BFB1528A6C766526A8B17254059429&tr=http%3A%2F%2Fbt2.t-ru.org%2Fann%3Fmagnet&dn=ISO%20standards%20%2F%D0%A1%D1%82%D0%B0%D0%BD%D0%B4%D0%B0%D1%80%D1%82%D1%8B%20%D0%98%D0%A1%D0%9E%20(%D0%BF%D0%BE%D0%B4%D0%B1%D0%BE%D1%80%D0%BA%D0%B0)%20%5B1973-2017.%20PDF%2C%20ENG%5D

edit: nice emo downvotes. Torrents today. Torrents Tomorrow. Torrents Forever! They're the only cloud that matters.
> "Blood types are differentiated by the kinds of sugar found on the surface of red blood cells. Type O has no sugars. Scientists had realized that some (gut) enzymes can remove the sugars from A, B and AB blood cells, turning them into Type O"

A superbly concise overview taken from another news article.
they came with helmets
>Data sharing is very very hard given the sensitivity of the information (patient data) - making it effectively impossible to have an open data exchange. (This is also due to the billions of dollars at stake on the pharma side).

There is promising work going on in this area to allow the sharing of models while maintaining privacy. (Differential privacy, homomorphic encryption, multi-party computation, etc.)
You should not consider Dropbox a file storage and sync provider, anymore. Dropbox (and almost all other big established storage/sync providers) moved to a new territory (market) called Content Collaboration Platform. This contains applications which provide comprehensive capabilities that support use cases from productivity and collaboration to content protection and infrastructure modernization. As some of you already mentioned, there are several reasons for it:

1. File storage and syncing is commodity. It is quite easy (compared to what was 5-10-15 years ago) to create a sharing & syncing capability software. Also, there are AWS/Azure as infrastructure so no one needs to handle this part of the business.

2. These big providers move to small-medium business and enterprise sector from personal users. It easy to understand, an enterprise contract with 5000+ users a year is much more profitable than acquiring loads of personal users who do not want to pay at all most of the times.

3. Lastly, big companies want to buy an integrated solution, which handles not just one thing well™, but contains extended functionality and support external providers. In Dropbox's case its file commenting, Zoom & Slack integration, etc.

Source: I work at an end-to-end Encrypted cloud storage and sync company as an analyst, reading market research and analyzing companies like Dropbox 9to5.
Anti-vax comes from anti-intellectualism, just like your opinion does. Two sides of the same coin.

It has nothing to do with "trust in agencies" and everything to do with intellectualism. We live in a society where academics, data, evidence, etc are all maligned.

How can you trust in an agency if you aren't willing to trust anyone at all?

The cancer is not trust in agencies, it's your culture of anti-intellectualism itself.

Trust experts or die.
Not everyone has Fugazi-esque morals.
Historically Satellite Internet has been much too expensive and slow for cases like this, but with new constellations like StarLink coming online it might be feasible in the future. The problem is of course that if the military is trying to prevent communication it's pretty easy for them to triangulate on transmitters in the country and send guys with guns to confiscate them or worse.
This article should be considerably hugely outdated as leaps and bounds of new information regarding early hominid cohabitation have been discovered since then.

It's safe to say at this point that humans are far more genetically diverse than previously thought and we may not share a single common ancestor considering that some groups contain large amounts of denisovan AND/OR neanderthal DNA that is non-existent in other groups.
Last Week Tonight with John Oliver did a segment on this recently: https://youtu.be/-tIdzNlExrw
Does it matter what I envision? It's possible. It might be useful. So it will be done.
I'm not very strong on biology, but does this mean, potentially, all blood can be converted to universal donor blood? That would be truly revolutionary.
And then I get a jar. Or maybe a war. Or maybe a zip? And maybe it's a fat jar with all dependencies bundled. Or maybe not and I need to fetch a bunch of deps and configure a classpath. And then I need the right JRE wherever I'm going to run it. And then I can run it like 'java -jar'. Or maybe I need a server like Tomcat. Or maybe something else.

And every time you jump into an existing codebase, you need to scrutinize the docs that are hopefully there to figure out particulars of the build/deploy process.
Awesome thanks for sharing!!
GDPR does not affect US companies that do not collect EU citizens information.
Your wit is subtle and dry - or lacking. I can't tell, LOL
What if you do not have a drivers license? You just get a fine?
Good way to convince people...

Call them stupid ;)
That's the thing about stories and literature, they can be different things to different people.

A story about loss can be a love song to one person, a dead loved one or a missed opportunity to another...
This is actually against comment guidelines:

"Please don't make insinuations about astroturfing. It degrades discussion and is usually mistaken. If you're worried, email us and we'll look at the data."

https://news.ycombinator.com/newsguidelines.html
> UK has its own political turmoil it's dealing with

To be clear, I don’t think anyone will intervene. But to say nobody has any leverage is wrong. There is leverage, it simply isn’t being deployed because Hong Kong isn’t a priority.
Yep, nobody buy F-35 planes because it's a superior airplane (it's not) countries buy it in order to have better diplomatic relationships with the USA.

It's pretty telling to see Germany refusing to buy F-35 or Hungary buying ones in order to piss off Sweden.
This is not useable for electronic prescription of drugs in the US. That is the problem I want solved.
You pay hardly anything to the agency -- their fees are a rounding error compared to all your other costs. And while it's valuable for some jobs to have on your resume that you used to work there, so many people have done so over the years that it doesn't raise any salaries; it's merely that for certain regulatory roles it's good to have someone who knows what it's like to receive the filings so you can make them clear.

It's utterly unlike the legislator->lobbyist revenue model or, say, the Department of the Interior where the regulators were doing drugs and having sex with employees of the companies they were regulating. It's more like "oh, you worked on DevOps at $LARGE_COMPANY_X, our needs are similar to theirs." Not the magic path to riches.
In other words, "The rich get richer and the poor get poorer."

Although, technically that Bible verse has significantly richer and more useful meaning than your interpretation, I don't think it doesn't mean what you said either. St. Augustine affirms the common opinion of the Church Fathers that each Bible verse may have multiple true meanings as long as they aren't incompatible with one another.

But I've seen this principle very truly at work: you have to spend money to make money. Those who have very little money to start with, usually can make very little money in return. Especially in software, if you don't spend a decent amount of money on advertising, you will almost never get anywhere.

Fortunately for those of us who don't have that money to make more money with, there are other things in life than money, and Jesus also says "blessed are the poor, for theirs is the Kingdom of Heaven."
He probably means in the way that Apple means it with SwiftUI and Catalyst. Cross-platform = Apple devices (i.e. macOS, iOS, iPadOS, watchOS, tvOS)
The authors are not using "constant time" in the complexity-theoretic sense. That would mean an algorithm whose running time doesn't depend on n,c.

The GCD algorithm here has the property that (I'm quoting section 1.4 here) "the number of operations is ... asymptotically n (log n)^(2+o(1))". That is not constant as n varies.

The nice properties they claim for their algorithm are:

1. The asymptotic running time is good. This is a complexity-theoretic claim. The asymptotic performance is of the same order as e.g. Schoenhage's earlier algorithm, so this isn't in itself any sort of breakthrough.

2. For fixed input size, the running time is constant. This is a cryptographic claim: it gives immunity to timing attacks. There have been earlier constant-time GCD and modular inverse algorithms, so again this on its own isn't any sort of breakthrough.

It isn't clear to me whether 1+2 is claimed to be new. I think it isn't: that is, there are other constant-time GCD algorithms with the same asymptotic growth of runtime.

3. The constant factors are good. This is a matter of the practicality of the algorithm. Here the authors are claiming to have done better than anyone before them.
Ransomware halts production for days at major airplane parts manufacturer
Slide 9 times, then head over to the jungle gym. Never leave the park!
What you're suggesting already exists. Nobody gets the smallbox vaccine anymore. People only get the rabies vaccine after exposure. There are a handful of vaccines you only need if you're traveling to certain international destinations [1]. The set of vaccines that everyone gets is already subset that everyone needs. And because of people expressing unfounded "skepticism" like this, we're getting outbreaks of diseases that were being kept at bay by the vaccines.

[1] https://www.cdc.gov/features/vaccines-travel/index.html
There is no evidence of this that you are aware of.

>There's no evidence of this. Since the leaks were about embarrassing unprosecuted US military murders of civilians arguably it saved lives by driving them to be more careful.

this is absolute nonsense
They have algorithms to pick which scooters should be moved and charged and compute a price to pay the people who charge them. You ideally want all your scooters to be fully charged before rush hour in the morning.
Also it’s important to understand the context that medicine wasn’t originally “scientific “ for all the reasons you are touching on.

Historically treatments were based on some theory of how the body works, and a plausible intervention either based job that model, or based on tradition and anecdotal experience.

As people tried to implement more empiricism it hits all the difficulties you mention and others ... it’s an extremely difficult ugly challenge.

We should have lots of medical reversals. It means we are slowly getting better. Probably things could move faster if there was some giant anonymized database of every patient treatment, with documentation of symptoms, intervention, and outcome.

There are so many reasons why that is impractical, I’m astonished we are making the progress we are.
I was thinking about it in terms of stalling for the 15 seconds it takes to make a response, instead of a reaction. But yeah, I totally agree that for those longer considerations, demonstrating the integrity to follow through is really important. My oldest is just 2, so this doesn't come up much yet. She has very little concept of tomorrow.

But I know from my experience with high school kids and with managing adults that people sort the peers and authority figures in their life into the buckets of "dependable", "needs follow-up", and "chaotic". It's like a credit rating. Maintaining that trust keeps a whole lot of other relationship dynamics healthier.
‘Pokémon Sleep’ Promises to Commodify Our Dreams
This is true, but there may be moderate reforms that would work. Could drugs approved by European regulators be allowed without FDA approval? Which regulators do a better job?
How I would address the mess is like this:

You have a choice. You can clean up the mess now or in five minutes. If you clean it up now, I’ll start a timer and I will help for one full minute. If you wait five minutes, you have to clean it yourself.

It’s their mess and their responsibility but there is no reason I can’t help. And these types of choices very often work for us.
Could trees be the new gravestones?
Frameworks I have used for UI work on Windows include MFC, ATL, WTL, WinForms, WPF, UWP and pure win32. After a while you kind of get burnt out on the never ending changes.

Apple might force you along but they seem to have fewer transitions overall and a much clearer strategy.
Have you tried bugsnag as well? sentry.io looks very cool!
Introducing Scene.js JavaScript Library to Create Timeline-Based Animation
Yes, Americans are #1 in the world for police violence. And congratulations to us!

edit: I earlier said that this was the first time HK used teargas/rubber bullets, which is inaccurate. the important thing is that this is still violence, just because the US beats everyone in terms of sheer scale/frequency/intensity of police violence doesn't mean that this isn't police violence.
Sure. Just like humans tend to do. Or not if the right person cares enough to program it not to.
> Assange participated in the leaking of classified documents, which is different than simply publishing.

This is an accusation made by the US government, it's not a fact. WikiLeaks accepted leaked documents and published them after verifying they were true. This is basically what journalists do (though they usually write articles that summarise the leaks).

Also, WikiLeaks did redact documents on many ocassions (in some cases even asking the US State Department what information should not be published). Everyone remembers the mostly-unredacted leaks of the war logs, but most people haven't followed up and seen that they did start redacting more things after the backlash. Though they never redacted sources or methods because those things have proven to help people in the past.
At AWS there is rarely a distinction between dev and ops. Developers manage their service and join the oncall rotation for their own team. We also write all our own tests and manage deployments ourselves (albeit with the help of other AWS teams who maintain test frameworks and deployment tools.)

This seems a lot cleaner than the alternative. Sure the devs have greater responsibility, but there's no dev/ops disconnect here.
I really don't know - I was never in that section of the business. Speculating...maybe they have their framework or some other VB6 piece certified for HIPPA compliance and don't want to change?

That industry is very old fashioned though - another good example is that every blue cross franchise uses the same software to process medicare/medicaid claims, and that software is powered by COBOL. At first it's shocking and you wonder how on earth things stay on the rails...but after a while you get used to it, a strange status quo.
> For me, prayer would have no effect. For others it could be a life saving intervention.

In the same vein, I often get to read about an emerging approach called precision medicine.

Precision Medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. It does not literally mean the creation of drugs or medical devices that are unique to a patient, but rather the ability to classify individuals into subpopulations that differ in their susceptibility to a particular disease, in the biology or prognosis of those diseases they may develop, or in their response to a specific treatment [1]

[1] https://en.wikipedia.org/wiki/Precision_medicine
>Do they get it wrong? Yes, occasionally. Not frequently. Occasionally. But that also, is science. The FDA follows rigorous statistical procedures, but even p<0.05 (or <0.001) still means false positives can happen.

The issue is that there is a huge lack of transparency. When a third of the studies involved in approval of anti-depressants were withheld from the public [0] and even some withheld at the insistence of the FDA [1], what good do low P-values do?

Hard to trust the science when you're not even allowed to review the papers for yourself.

[0]: https://www.nytimes.com/2008/01/17/health/17depress.html

[1]: http://www.washingtonpost.com/wp-dyn/articles/A9802-2004Sep9...
Right, that’s what I meant by “a clean interface to their boss”—because they’re unaware that rethrowing these exceptions is a (perhaps implicit) part of their job description, and they certainly don’t think it’s part of their boss’s job description, they think that 1. they’ll be doing something they’re not supposed to be doing by rethrowing the exception, and 2. it’ll be their own boss’s job to handle the exception, probably by throwing out the report and then trusting them less to get stuff done on their own.
It's a little depressing how long it takes to complete projects like this, but encouraging that they're even trying. So... I guess I feel neutral about this on the balance. Anyone wanna take bets on how delayed and how much over budget they'll be?
Interesting they say "suck it up, lie, or resist". The other way is to push the requirement further down: I don't understand this thing you're buying but you have represented to me that it is necessary.

That's the actual responsible way to do it.