skysight-inc/HackerNews huggingface dataset:
This paper is a PR gold mine but a methodological disaster, which is par for the course in "EWAS" (epigenome-wide association studies). At one point I had to remind a coauthor that pointing out structural problems in fashionable studies such as these is a quick way to lose (more) faith in modern peer review; for some reason she thought that EWAS enthusiasts gave a flying crap whether the "genes" they were studying were subject to structural variation (e.g. amplification and deletion). Ha! Ha! Ha!

Anyways. Their functional enrichment analysis is uncorrected for the known bias of the platform (something that has been repeatedly addressed by multiple authors since 2012), and no attempt appears to have been made to correct for cryptic stratification (i.e. structural polymorphisms, which are rampant in human populations, and particularly among so-called metabolic genes), though in the study population that may not be a major issue.

Quantile normalization is only appropriate if one can reasonably assert that the overall distribution of measurements is roughly the same between individuals and groups; this assumption has been shown to be invalid in the absence of positive and negative controls for gene expression, whence its original propagation, and more so for DNA methylation under various conditions. The batch correction approach used here is notorious for squashing real signal, although paradoxically that may have moderated some of the other methods choices.

Moreover, the paper demonstrates that a particular sample of high-SES vs. low-SES individuals in Cebu in the Philippines demonstrates some (fairly tiny) differences in DNA methylation at a relatively small number of CpGs (about 2000 out of 485000 or so measured and 110000 or so tested), without particular note as to whether the sites are clustered, functional, or otherwise of interest. The functional impact of these changes are difficult to interpret, partly because of the bias in the functional analysis (something that has been established for nearly a decade; the authors clearly went shopping for methods in a "confirmatory" style).

We shan't even bother to discuss the effect of [mal]nutrition on metabolism and thereby upon DNA methylation and cell composition (both intertwined, although an attempt was made to correct for the interaction), which further muddies the waters w/r/t SES as opposed to individual-level effects. The analysis is done with a fixed-effects model assuming unstructured shrinkage, which of course is a bit odd considering that the measurements have a relatively easily determined correlation structure (their sample size is sufficient to estimate this) and thus variance decomposition could have been highly informative. This is doubly odd for a population "epigenetics" study, given that variance components were literally invented in population genetics.

In conclusion, while it's a lovely piece for a PR department, the actual relevance of either the measurements or the phenomena to actual humans and public policy is quite difficult to interpret. Perhaps that was the point...
Created by AMD and supported in only a subset of AMD's cards. Appeared in 2013 (so, a year before Metal, and by that time Apple had probably already invested millions in Metal), and abandoned in 2015.

So. What about Mantle?
We need strikes in america. I don’t see any other way. This is a fairly useless action yourself. I also don’t have great answers, obviously.
Maybe this will turn out false, but I predict the legal system will blame whoever has the deepest pockets, just like when there's an accident with human driven trucks. And the suits will be settled in a way that does raise the cost of doing business, to your point. But I predict it won't be severe enough to kill the business outright.
SMS two-factor authentication API tutorial to verify phone numbers
I feel like my whole environment is self modifying, given the constant auto updating it wants to do :)
Or maybe the fact that there has been a population explosion on the west coast due to tech combined with a retarded attitude towards urban development has resulted in more people than available bedrooms.

Ima go with that explanation since it is a lot simpler.
One aspect of a polygraph test is to hammer the same questions over and over at staggered intervals and see if the signal response differs.
It’s not a binary choice between owning a cat and letting it wipe out as much of the native animal population as it can. Again, encouraging people to let their animals wipe out populations of wild animals is wrong, and doing it because it allows your domesticated animal the freedom of feeling ‘natural’ is a supremely selfish behavior.
I perfectly understand anti namespace conflict clauses. Luckily this is usually already done in practice when open-source projects are forked. mplayer -> mplayer2 -> mpv, ffmpeg -> libav, openoffice -> libreoffice, etc.
I was a lot more compassionate 5 years ago when I thought Seattle could solve its homelessness problem. Now that it’s clear we can’t I just feel bad for everyone involved.

There are entire parts of my city (parks, downtown) I can’t even visit because of the homeless. Maybe someone who falls on hard times doesn’t deserve jail time but if you steal or break any other laws you need to face the music, just like everyone else.

The homeless deserve dignity and respect but so do the rest of us, I feel like that has been forgotten.
> Makes you wonder what the purpose of high school was in the first place.

Oh, I have an opinion about that:

Well. First and above all the first purpose of school and high school is to learn to follow authority (edit: authority in every other meanings. Tthe first authority to submit oneself to is the school). This is the first brick and if it's not assimilated in a way that suits the school the student will get thrown out of the system.

A century ago there's the industrial revolution mantra: produce workers who can read and understand semi-complex or complex instructions in written and oral forms and manipulate tools (typewriters, screwdrivers, hydraulics, mechanics, machines, etc.).

And now there's the "learn to learn" mantra because few things taught in the 'regular', 'normal' or 'general' school and high school cursus land jobs in the post-industrial and the information societies. Does not seem to apply to trade schools.
I am really impressed with the quality of the content of Real Engineering, the video's YouTube channel. And they pump out content like this every week. That sounds like a lot of work.
I still don't buy the "There is no nature vs. nurture" statement. Maybe there's more than nature vs. nurture, or more complicated than nature vs. nurture. But totally no nature vs. nurture? Overstatement.
I am very happy about that. I Interviewed twice at jet.com for a senior developer role and they were a bunch of arrogant bastards.
Very possibly reversing causality. That Brookings paper itself states that the economic downturn predates the 'opioid epidemic'. It's based on data that adds up to little more than, well, what you quoted - with little effort to prove which direction the causal link runs, although the paper seems to take for granted it's the drugs causing the labor participation reduction.

The author, describing his assumptions in building his model (pg 36), states "This is a big leap," - language I've never actually seen in an academic paper before. It's usually the sort of thing that peer reviewers say behind their hands before throwing barbs at you.
Right, I'm not asserting that my alternative title is the correct one, I'm lampooning the assertion that IMDB is "suffering from recency bias" as opposed to a more neutral claim like "ratings for more recent movies are higher."

Answering the question of _why_ they went up is a lot harder to prove.
Well, simply correct your mistake and tell him to switch. Or even better, configure it for him. I've done so for all of my "like your dad" people.

Perhaps sites aren't as broken in Chrome now as they were with IE, but you can bet the web itself will change in ways you and I would consider broken if Google is left to become the sole, unchecked steward and helmsman of the web.
You know it doesn't actually matter right? Transgender people / Trans-the-concept doesn't appear in the Bible at all. Not a single word. And yet, Christians still vigorously claim they're "against God" and "immoral".

And why? Because at the end of the day, many Christians (and lots of other people tbh) construct a byzantine mansion of circular reasoning, to justify their shitty bigoted feelings towards LGBT+ people.
>pointless, for example unlimited coffee refills at a restaurant

Low marginal cost of drip coffee certainly enables restaurants to offer "unlimited" drip coffee refills. (Quotes because you might get a nudge to buy something else or leave if you hang around all day.) But deciding to do so is driven to a considerable degree by the prevailing customs/practices. You at least partly get free coffee and soda refills because customers generally expect them in the US.
I assume the vast majority of these species are insignificant insect species almost no one has ever heard of?
I stand corrected, your grammar is certainly not the result of an European education system.
How a “this” became a “that” on HN
https://wiki.gnome.org/Projects/Tracker

Most gnome based distros have that available, if not enabled by default. Not sure what kind of support it has for different file types.
Good timeline with pics here:

https://www.scmp.com/news/hong-kong/politics/article/3014695...
Are you referring to the first or the second part of that sentence?
I don’t disagree with you but I want to point out that it’s interesting how better software, running on an OS, running on a chip architecture, has enabled us to write better OSs and better chip which in turn allows us to write better software that allows us to repeat the cycle.

Aren’t we somehow simulating how life works? Higher abstractions/constructs improve the way the lower constructs work :). Of course, just an oversimplification.
>Sure. I don't dispute that the author of the text in the NT was probably inspired by Leviticus. And both Leviticus and NT use "men" there.

Cool, just to clarify, the word means 'male', not 'man', and is applied to animals as well as humans.
> Electricity still has limits based on wire gage. If the cost of maintaining the distribution network vastly exceeds the cost of generation, it may not be worth the billing hassle vs simply paying for the size of the pipe.

Distributing the generation makes this less of an issue, you still need connection between the regions for balancing and load-shedding, but one can imagine that had civilian nuclear been more of a focus local and hyperlocal SMR would be old-hat rather than experiments.
I think the South East Asia region will be more stable if Taiwan, a democratic nation, rises in power and gets less influenced by CCP, whose legitimacy depends largely on fast GDP growth, which is increasingly impossible in this age of excess production and currently is done only with unsustainable credit expansion. Recently Xi is switching the legitimacy from fast GDP growth to revival nationalism--the so called Chinese dream [1]--but such aggression is also destablizing to the region.

Some coordinated efforts in the free world to raise Taiwan would help, but at least Taiwan is gaining a little bit from the recent trade tariffs [2].

[1]: https://www.eurasiareview.com/08122018-the-contours-of-xis-c...

[2]: https://www.bloomberg.com/news/articles/2019-06-03/vietnam-t...
From my experience, Docker helps quite a bit with CL stuff in many cases. When you use some shared libs via CFFI, things can get fragile quick, start depending on a particular shared library version on the host system etc. So your app, for instance, works fine on Debian jessie, then you have to upgrade your host system to stretch and oops, it broke here and there. You update your quicklisp dist to fix shared lib incompatibility problem and oops again, you need a week to fix stuff that broke (this reflects some problems with CL library management, too), but you need to have your app up and running on the new system yesterday. If you wrap your CL app in a Docker image, you can continue running it on the prev distro version till you fix it to be compatible with the newer one. And that's just one example.
What's going on with those first two images? The first one is clearly mirrored, though also placed a little off-center. Are these renders? A mashup of rendering and actual photos? Just photos with one mirror effect? I'm genuinely curious.
> of 4 of the 6 clobber passages, all these nations and translations were referring to pederasty, and not what we would call homosexuality today

I would have liked to hear more about this. What are the other 2 passages, what do they say, and how might it have been changed over time?
Most sites can switch from ntpd to something else. See for instance systemd timescynd which really doesn't have a reason to exist. And changing to chronyd was a very quick switch.

I think it is really inertia. Time synchronization goes unloved at a lot of places.
I once read that King Arthur is one of the crowning (pun probably intended) counterexamples of "history is written by the victors": if the Anglo-Saxons really did write the history of the Sub-Roman Britain period, we would have heard more about the Völkerwanderung and less about Arthur and Badon. But maybe what you said is more correct, that history was adapted by the victors (who then became the losers).
We are absolutely feeling the pain of a lack of social safety nets for all kinds of problems.

Unpopular opinion: I’m ok putting non-violent people in jail when they break the law. We need reform in the jails and prisons, not more lenient sentencing.

And because I’m sure it needs to be clarified, not every law breaker needs to go to jail immediately.
This argument presupposes that users are informed about what is being tracked, what that data can be used for and the user consents. None of these are true. Hell I bet most web devs embedding the tracking script la even understand the full implications of them. To make it worse, The big players are constantly adopting darker and darker patterns to inject more and more tracking.
There's Recoll: https://www.lesbonscomptes.com/recoll/

I haven't used it, so I'm not sure how fast it is, but I've seen it recommended several times.
And yet something guides the human zygote in developing as a human. At what point do we stop focusing on refuting simplistic ideas and turn our attention to what is now known?
Is it necessarily a bad thing to be a net debtor? Generally when a business or country borrows money it's because they can put it to some productive use that generates a greater return than the cost of borrowing. If the US is borrowing money, it means that it's making productive use of other countries' assets and getting return from those assets that the other countries are not. This should be a good thing (for the US).

People tend to react to news about national debt like it's their credit card bill that they ran up on takeout food and flatscreen TVs. It's not really the same thing.
Global market share stats are applicable for global target websites. Consider any medical equipment company for example - their clients will browse the catalog from archaic, unmaintained PCs they have laying around.

Always get data about browser market share from your client if they have it, otherwise you're simply in for an uncomfortable surprise one stats start coming in.
I left the US to Finland for one third the salary and twice the taxes, but I gained a priceless work-life balance.

My work colleagues are relentlessly competent, and part of that competence is valuing family and leisure.
Ask HN: Why Edgar F. Codd is not recognized as a CS legend?
He is the inventor of the relational model for database management. I've never seen him mentioned here. He did as much for the progress of our field as other more famous names (Knuth, Torvalds, Ritchie)
Designers or developers.
The simplicity of the LLVM source. Edited for clarity.
> Then we'd
like to get back instances
of Python objects exactly as they were created.

I would accept the challenge as long as the objects in question are dictionaries.
Yes, on re-reading the thread again it might be entirely (or almost) about language. As in, it's really something along the lines of 'The power of the JIT approach comes from runtime information and dynamism. But you can also be a 'just' a JIT without making use of any of that'. And I'm getting stuck on 'secret weapon [...] soundness' and imagining some unfathomable-to-mortals ninja something.
Tsai has destroyed Taiwan demarcracy. Her lead in the poll is simply the result of her political manipulations. The poll is not trustworthy. She has split the people in Taiwan. She invites wars among people so that she can maintain her power. She violates so many rules to win elections. The approach is extremely disgusting.

So sad to see so many irrational and under-informed young Taiwanese people become mentally disabled due to the political brainwash, hatred speech, and self-righteousness.

They are going to be the generation of conflicting and fighting. But they will simply be fighting the lies they believed in.

The only hope left in Taiwan is HanGuoYu. Unfortunately, not everyone can see the truth.
When a government deploys violence anyway people do have a right of self-defense. There's a broad spectrum of criminality from refusal to disperse following an order to do so, through interferences with public property like removal or deployment of barricades, through interference, confiscation or damage to vehicles, through direct physical confrontation which has its own escalatory tree.

Non-violence is a position but must have limits, otherwise you are demanding that people become punchbags of the state and preemptively invalidating all resistance against oppression, thereby amplifying the oppressor's narrative. A government in sufficient trouble will kill nonviolent people anyway and while it will lose moral legitimacy it is often willing to accept that as the price of strategic advantage, because the reality is that state actors can get away with killing people under many circumstances.

What we sometimes see (as here) is a triangle between government, capital, and people. Capital threatens to depart if government is overly aggressive and likes to pat itself on the back for its regulatory capability, but at the same time capital uses government to keep people subservient to those who control the wealth; one might say it's similar to fleecing sheep and aiming to slaughter as few and as humanely as possible. Large capital interests farm people within the legal and executive infrastructure of states for all practical purposes.
Well, given how people who come up with ideas like that think, yeah, they probably would like all the poors to be removed and shot or something. It's just how those people think.
Yes, but I wasn't talking about the seatback devices ;)
Same here, I always wondered why it was the case that I felt hungry in the morning after drink a few beers the previous night, as in general I don’t feel any hunger till noon.
That point is already defined, it is called Emacs.
I very much like that the site is a good example of the manifesto: very lean, still good looking.
Everyone who wrote and authorized this press release ought to be fired. The paper offers no evidence of relevance to epigenetic inheritance, and has nothing to do with nature vs. nurture.

All that's going on here is that people in the Philipenes have differences in environmental exposures that affect gene expression in their immune system, and this, unsurprisingly, differs by SES. No evidence that any of these marks are more than temporary marks of current gene expression patterns let alone anything as shocking as passing through the germ line to the next generation.
Please don't use HN for political or ideological battle, or post flamebait. This is in the site guidelines: https://news.ycombinator.com/newsguidelines.html. Would you mind reviewing those rules and taking the spirit of this site more to heart when commenting here? The idea is to read what gratifies your curiosity and post from that place.

We detached this comment from https://news.ycombinator.com/item?id=20196747 and marked it off-topic.
It makes no sense to leave things out of a description of a complex system to help someone to understand it better.

Have you considered educators might not want 17 year olds to understand things that are "too dangerous"? Because that happens at a pretty basic level in chemistry.
Show HN: Building a CI/CD on GCP with Kubernetes
Hey once you're past the fundamentals check these two cool games out. They teach how to quickly grasp the most difficult parts of CSS - the layout.

https://flexboxfroggy.com/
https://codepip.com/games/grid-garden/

I wish all learning was this fun.
> Python has been updated to 3.7.3, and we have successfully removed dependencies on Python 2.x from the main install image (for now, Python 2 continues to be available in the repositories for people who need legacy applications);

This is cool. I wish ubuntu/debian would move towards this.
To be pedantic, Apple is a company, not an OS :)
Not very lean to me. It lags while scrolling on my phone.
Yup, there's a lot of information that can seem to point in contradictory directions, but you get some very, very clear signal out of it in a couple of important directions.

People still seem pretty resistant to simple interventions like this though. I think a big part of it is that most people have an incredibly powerful status quo bias, and get extremely uneasy with diverging from the norm of behavior they see around them (even if those norms are of generally far worse health than they're targeting).

I've spent the last decade incrementally understanding more about nutrition and optimizing my diet, and I've reached the point where the divergence between mine and my friends' diets has become pretty insane. Not coincidentally, now that we're starting to enter the period where age catches up with our bodies, I'm by far the healthiest, by both appearance and symptoms. I've had friends ask me what I do, but it's far enough outside the norm that they assume it's impossible or that I have iron willpower (spoiler: I really don't. If you eat healthy, your tastes shift towards healthy food).

This is a general problem with people; in the narrow case, it could be solved by changing their environment (ie blanketing the country with PSAs with simple messages, like we did for smoking). It would do infinitely more good to somehow grant people the intellectual confidence (or indeed, capability) to avoid blunt heuristics like the so-called "wisdom" of crowds, but I have no earthly idea how one would do that.
> But two of the main maintainers, Oracle and Red Hat, absolutely do.

BTW, Oracle contributes ~90% and Red Hat ~5%.

> It's technically accurate but substantially disingenuous to suggest that 11 is not Java's current LTS.

Either way that has little significance here. It is not the most popular version of Java in use today (that would be 8u2XX) nor is it any more production-ready or stable than 12. You can say that we're interested in results for the current version of Java or in the most popular one. I don't understand why it would be particularly interesting to discuss JDK 11, which is neither.
Please don't post flamebait or start flamewars on Hacker News. We're trying for better than that here, and this one was pretty bad.

https://news.ycombinator.com/newsguidelines.html

Edit: it looks like we've had to ask you this many times before and also that you've made a habit of posting unsubstantive comments to HN. Could you please not do those things any more? We'd greatly appreciate it.
I am a mechanical engineer, and yes it is. The composites are simply too new to have all their properties adequately modelled yet. And they are a moving target.
Try synapse
https://www.omgubuntu.co.uk/2016/10/your-favourite-alfred-ap...