skysight-inc/HackerNews huggingface dataset:
An old XKCD is, as usual, highly relevant: https://xkcd.com/1217/

Granted, this is actually a trial in humans, so that's good! But if you look at the study, the focus is on detecting circulating cancer cells; attempting to use the technology to destroy them is relegated to one paragraph near the end. There they note that this seemed to happen by accident, to a limited degree, in 6 out of the 18 patients; so they tried again in a single patient, whose melanoma cell melanin content was particularly favorable for this process, and it again seemed to work ("up to a 48-fold reduction" in circulating melanoma cells.)

They went on to do in vitro tests to try and show it would work in general, aiming the laser at a test tube full of blood; this worked, which is encouraging, but it shouldn't be taken as a strong indicator of anything practical. (And even there, they note that the melanin content of the tumor cells is important to the treatment's effectiveness.)

And yes, it's only targeting circulating melanoma cells. This tech can't just aim a laser at a tumor and kill it; it probably isn't useful for non-solid cancers like leukemia, either. So while this is cool and interesting, it's not a huge breakthrough in cancer treatment.
Please don't spam the same comment multiple times.

https://news.ycombinator.com/item?id=20168111
> The rule limits Google's proposing are more generous than the limits Apple puts on content blockers

And Firefox and most Chromium forks have no limit. Does that mean they have infinite generosity?

Seriously, how is Apple being bad at something an argument for lowering other options to the same level? Right now I have ~200K filters enabled on this machine. EasyList alone is sitting at 90K according to uBlock Origin.
Yep. Literally nothing is wrong with this. You're barking up the wrong tree.
Canada prescribes Heroin to some addicts... costly, $24K/year, but potentially ROI positive given the break-ins, petty crime, and cost of responding to it (police, insurance costs, etc.)
It will be really hard to argue for a complete redesign of a medical device app, complete retesting and waiting for FDA approval only because some guy at IT doesn’t like the devs to have admin.
If Apple has a bad quarter with iPhone sales, every shareholder takes notice and a lot of verbiage is written to shareholders to explain why that may have been the case and what if anything is being done to correct sales projections for the next quarter.

Google doesn't have any products that are similar. Google mostly only answers similarly to shareholders if ad revenue is down. It would potentially take a lot to change in the world for any product to rival Google's ad revenue in prominence on shareholder reports.
This is a perfect description of my issue with their symlink handling, and their arrogant response to the complaint about it.
I'm curious, is this in the context of asking them to perform an actual written review of your product or were you just inquiring about sponsored links/ads/mentions/etc?
My grandmother in the US has severe dementia and an active drivers license.

My grandfather doesn't let her drive, but legally there is nothing stopping her. It terrifies me when I go to visit their retirement village because any car I pass could be a similar story.

Unfortunately there is no solution because no politician in Florida is ever going to propose legislation that limits the elderly in any way.
I agree with what you're saying but that chart isn't accurate at all. GHB isnt toxic except at massive doses, it metabolizes into water and carbon dioxide and is a first-line prescription treatment for narcolepsy.
Why do you think it is very effective in Rhode Island? Oklahoma, which I think pioneered the concept of a special drug court for forced rehab, has maybe a 10% success rate.
Prepare for a complete reversal of the role the Supreme Court plays in our lives
Holy cow, I could not agree with you more. As someone who has lost loved ones to drugs (they got something other than what they thought they were buying) and also to suicides over having their legal opioids taken away from them due to the "opioid epidemic," I think you are spot on.

For the skeptic out there: ask yourself if your loved one wanted to overdose or if it was an accident. I bet the majority of cases were unintentional. Had the drugs been clearly labeled with doses and checked for purity, your brother/sister/father/mother/friend might still be here. Mine would for sure.
Going from 2 to 3 isn't that hard because Python 3 was released ages ago with the expectation that the changeover would be gradual.

The only ways I can see to make it that easy on the day Python 3 was released are (1) no backward-incompatible changes (but enabling such changes was the whole point of Python 3) or (2) doing all the preparatory work before "releasing" Python 3, which in practice would have taken just as long and required there to be a pre-release Python 3 to work with.

#1 misses the main point of having a Python 3 at all. #2 basically looks just like the way things actually are, except that Python 3 is labelled "alpha" or "pre-release" or something for years longer.

People like to complain about how slow the Python 3 changeover has been, but it seems to me that it's worked. The obvious point of comparison would be Perl 6, which hasn't exactly been a triumphant success. (Though there are many other differences between Python 3 and Perl 6, and it's not at all clear that Perl 6 would be widely used if they'd adopted a model more like Python 3's.)
The Race to Become the Beyond Meat of Fish
The post isn't "Why did people want IPv6" but "Why is IPv6 such a complicated mess compared to IPv4? Wouldn't it be better if it had just been IPv4 with more address bits?"
"Fighting" lol.
Please don't use indent for lists. It breaks formatting severely on mobile, and in this case even on my 4k desktop monitor.

Unintended copy of the comment below...

I do a lot of UI/UX design as a part of what I focus on, both at work and for fun. This page is a juxtaposition of well thought out elements and things that make me go `???`.

Like:

- Good product marketing messaging

- Well done images and GIFs that get to the point

- News-site like past first article scrolling, I bet it drives more engagement. I even like how the UI elements change color when you go to another article.

What?:

- Huge spinning circular thing at the top

- Content not taking the whole size of the page but strangely taking the right 2/3rds~

- Non-retina images

Would love to see metrics on:

- Tweet highlight integration. Does it drive valuable KPIs?

- Font: They are using https://sharptype.co/case-studies/dropbox/ . The case study from the foundry that made that font has a section with color `rgb(181, 208, 230);` font on a `linear-gradient( #d20b28 , #d20b28 );` background. That's light blue on somewhere between scarlet, crimson, vermillion or venetian red color space. My brain slightly breaks reading it. Does having your own font drive engagement? What do the KPIs on that look like?
Life expectancy in India down by 2.6 yrs due to air pollution: Study
10% of Chinese exports are to HK.

HK is tiny. The importance of HK for China is in international trade and finance.
Well, at first gamers said dual-core chips are useless. Then that quad-core chips are useless. Now they're testing waters with octa-core chips.

Game developers have always made a good use of the available resources. They'll use the extra power available. The newest techniques they have, like work stealing queues, can scale to a large number of cores.

So games and gamers will use the extra cores. It's much less of a jump from 4 cores to 16 than from 1 to 2.

Give it a year or two.
There is no confusion. It has x16 lanes for graphics/slots, x4 dedicated lanes for NVMe storage, and x4 lanes for the chipset.

The chipset multiplexes up to x16 lanes of "stuff" onto the x4 chipset lanes from the CPU.

All of this is physically determined by the pinout of the socket and none of this can change unless AMD moves to a new socket. What did change is the speed of the lanes - x4 lanes on 4.0 is twice as fast as x4 lanes on 3.0.

AMD, like Intel, likes to pretend that chipset lanes "count" as full CPU lanes, arriving at a total of 36 effective lanes. But that's nothing new either.

https://www.techpowerup.com/img/PXQ4X5jG1JfBexk6.jpg

https://www.techpowerup.com/img/HMRSMmd3jbU2CVX0.jpg
Yes, no doubt this community has the largest percentage in both categories of "self-hosting". I have VPS's in multiple countries as well as hosting from my home.
Not common among extreme-low-carb diet people.
Sadly, the dozenal system was basically done for after the release of "The Art of Tenths" by Simon Stevin in 1585, and the resulting adoption by traders and tradespeople.

But well, the decimal system is probably the second best...
My main gripe these days is the lack of consistency : while hours/minutes/seconds are not too bad, having computer screens in inches annoys me a lot ! (While TV screens are in centimeters, as expected.)
>This looks like a good way to spark real-life violence in what is otherwise a remarkably safe way to exchange drugs.

If you believe what they are doing is bad and must be stopped, then it makes such a choice seem like the relevant thing to do. When the violence does come, it provides more support for the laws in the first place. From the view point of someone who disagrees with those laws in general, I find it evil. But seemingly well thought out evil. Given their existing ideology, it makes sense.
The desire and use case for a universal application package/runtime and an API to run that packaged app are not ever going away.
https://github.com/dlang/druntime/blob/v2.086.0/src/core/thr...

D's implementation ^ (Linked partly because the inline assembly is very clear)
Revealed: Mobil sought to fight environmental regulation, documents show
Opensecrets is a good source: https://www.opensecrets.org/industries/indus.php?Ind=A

I don't have the details of the contribution amounts of the Ferrero team on Kinder Suprise Eggs.
> Not to mention the long-term medical side effects of heroin usage...

The constipation?
You guys could also build some shelters.
True. And? While I understand the need for a level of competitive relationships, would it be so terrible to put the burden of selling arms to gross human rights violators on other countries?

Of course, it COULD be bad. Real bad. Hand-waving away such concerns is irresponsible. Having a major oil source friendly to an often hostile nation could have real, even deadly drawbacks.

But so too does always turning a blind eye. If we had gotten into this relationship and worked to reduce the threat (such as investing in other energy sources) we'd be in a better position, we could be at a point to change the relationship at reduced risk. We didn't, and we need to face the concrete realities we're supporting out of fear of hypotheticals.

Because now we may be safer, but we're supporting what we proclaim to be against. When we wield moral superiority, it's undercut. When we tell our children to be patriotic, we know the legacy we're leaving them.
> Unlike plastics pesticides like Glyphosate get 'locked' into the body --- meaning your body cannot wash them out through its usual means --- resulting in cancer and what not.

This is utter nonsense. Glyphosate doesn't get "locked" into the body.
Define "work"? Dropbox has never sync'd a symlink as a symlink - it follows then on the client machine and a copy is created on the server.

(Source: worked there)
I actually agree with most of this. However, one must recognize that Google is not solely responsible for Kubernetes at this point. Under the banner of the CNCF, K8s is worked on by literally hundreds of companies and thousands of developers whose interests are not necessarily all aligned with the "Rent-Your-Server-From-Me" lock-in doctrine espoused by the large cloud providers. Many companies have an interest in making K8s easier to use from an operational perspective, which gives me hope for the platform's future.
This sounds too simplistic. There are other factors, like large debts (domestic, foreign, or otherwise), extra-marital affairs, etc. that could make someone easy to turn in the future.
These conditions are exactly what prompted the drug war's start in the first place. Neighborhoods were tired of the addicts and petty (and sometimes not so petty) crime which plagued their day-to-day lives.

I wouldn't be shocked if 10 years from now, these coastal cities are leading the charge on a tough on drugs reversal.
>Does that mean that privacy is dead by an inexorable process?

Yes.

>Doesn't that imply that individual liberty is also, eventually, dead?

Yes.

>How can we, the people, administer the thousand cuts?

Stop carrying a cell phone.

There was a brief period of time, from 1990 to 8:40 AM, September 11th, 2001, when you could do all sorts of stuff online, and the powers that be either didn't, or couldn't, monitor it. That's changed, and that freedom will never come back.

However, no matter how bad the modern surveillance state gets, contrast it to the ancestral environment: a village of 50 to 200 people, most of whom are related to you, watch your every move, and can determine if you live or die. Hunter gatherers don't even have a word for "privacy". It would take real creativity for things to get that bad today.
yes but it won't give them your location, it will give them the courier's. the location history would put your device in totally random locations during the time you want to be anonymous, but it wouldn't look like you just left your device at home either in a way that didn't fit your pattern.
I don't think we're disagreeing in what either of us said, but only in whether it's the best idea to invoke historical sexist ideas (by saying simply "women", as if all else is implied) unnecessarily. Especially when we're talking about tragedies that could be direct effects of those kinds of historical ideas, so it should be on our minds.
Clock in by 9:30 Am, No Working from Home
Shazam-like technology used to identify bars illegally streaming soccer games
This looks like a good way to spark real-life violence in what is otherwise a remarkably safe way to exchange drugs.

How? The whole point of the dark web is that you don't know who you're dealing with so who are you going to seek revenge against if you think you've been wronged? If you mean the second-order effect of people giving up on the dark net and buying drugs of questionable quality from a dealer on a street corner (with all the implicit violence of illegal street crime) that's likely true; but policing is an instrumentality and wishing they weren't is to say that the police should shape policy, which creates a whole new set of problems.

Without endorsing the drug war, this is going to happen any time you have asymmetric conflict with incomplete information. So while I think all drugs should be legal and we should concentrate on education and harm reduction, the same techniques will be deployed against other things that everyone does agree are crimes, from the manufacture and distribution of child porn to disrupting violent organized crime networks. Wherever there is a demarcation of liability actors on both the supply and demand sides will operate independently to penetrate it and establish a bidirectional channel.

So while I'd like to see the drug war ended right now and a full pardon for everyone who hasn't committed murder or extreme violence, the philosophical aspect of this is never going to go away because it's a fundamental strategy, arguably rooted in biology if not deeper.
I could purchase a semi truck today and drive it despite the fact i'm not licensed. I don't see how it's any different - the thing stopping people from driving vehicles that they don't have the license for is that it is illegal and you can be punished.

Repossession doesn't come into the equation - the same way I can buy a truck, they can buy/own a car that they aren't allowed to drive. It makes sense that they would sell it and buy one they are licensed to drive, but nobody's making them if they want to sit in it and make car noises while not moving.
Why most and not all?

Also, given how many existing drugs are already legal, couldn't one say that most already are legal and that hasn't been enough to fix the problem?
One thing to keep in mind is that GraphQL really supports a different use case than something like gRPC or REST.

One of the places where it really shines is providing a queryable API entry point to a graph of interconnected data. This makes it ideal for generally reusable APIs for consumption by a variety of clients (e.g. GitHub's GraphQL API).

gRPC interfaces are typically use-case specific, and performance oriented (though GraphQL doesn't specify any sort of transport protocol, so you could always serialize GraphQL request/responses with protobufs to gain some performance over the wire), making them well suited for server-to-server communication, but not generally reusable.

REST is resource (i.e. nodes in a graph) based, but doesn't necessarily do a good job of making the relationships explicit and easy to traverse (I'm sure there are good HATOAES implementations out there that address this, but I haven't seen one).

Both REST and gRPC have their place, but I think GraphQL is a clear winner when you want to build a single API to service a large number of distinct clients. It really does offer a clear, easy-to-use API abstraction over where ever you might get your data from.

Also, since you call out code generation specifically; GraphQL provides a strongly-typed schema that can be introspected against, and the tooling to parse queries/schemas into abstract syntax trees. A large number of tools have been built with these capabilities including a number of different code generators. I've even used a GraphQL schema to generate a matching XSD (ugh) for import into an internal business rules engine. Made integration a breeze.
A citation would be nice. They seem to help repair traumatic brain injuries and other types of brain damage.
I think it is worth noting that historically, land-locked countries tend to be less well-off than its counter parts. Examples such as Switzerland & Austria are an abnormality due to a variety of unique factors that have only occurred in Europe so far.

Overall, the rule of law, regulatory environment and open market of Uganda and its neighbors are not at the level needed to to maximize its potential. This, coupled with the cost of borrowing (think interest rate), asset risk (E.g, forfeiture, robbery, piracy) and a few key negative economic indicators (Major balance of trade, current account & gov budget deficit) can put a dent in a country's mid-long term success.
Using Cypress to Write Tests for a React Application
US tech companies can’t decide whether Huawei poses a security threat
But will we spare the guards when the walls fall?
I don't think it should be assumed that the homelessness is caused by the addiction, rather than both being comorbid to some third condition. Certainly some homelessness is caused by addiction, but for some a mental illness could be the cause of the homelessness and the drug-use may be an attempt to self-medicate that mental illness. In that scenario, providing clean and safe heroin would improve their quality of life, but wouldn't address the underlying condition or the subsequent homelessness. The family living next to the tent city will probably still feel pretty upset about the state of things.
Debian 10 will be released on July 6, 2019
This is extremely human- and Earth- centric. It's as if the only life we're interested in finding in the universe -the entire universe- is life identical to life on Earth. Life that needs an environment just like Earth, and can't survive in any environment that is not like Earth. Life that even has hemoglobin! How likely is it that all life in the universe must be like life on Earth? Actually, by the study reported in the above article- very unlikely.

Anyway, I'm reminded by this quote by Douglas Adams (veers off to something else entirely but it starts very relevant):

Imagine a puddle waking up one morning and thinking, "This is an interesting world I find myself in — an interesting hole I find myself in — fits me rather neatly, doesn't it? In fact it fits me staggeringly well, may have been made to have me in it!" This is such a powerful idea that as the sun rises in the sky and the air heats up and as, gradually, the puddle gets smaller and smaller, it's still frantically hanging on to the notion that everything's going to be alright, because this world was meant to have him in it, was built to have him in it; so the moment he disappears catches him rather by surprise. I think this may be something we need to be on the watch out for. We all know that at some point in the future the Universe will come to an end and at some other point, considerably in advance from that but still not immediately pressing, the sun will explode. We feel there's plenty of time to worry about that, but on the other hand that's a very dangerous thing to say.

https://en.wikiquote.org/wiki/Douglas_Adams
The original point was that the American drug policy causes a lot of violence. This public beating was used as an example. Would he have been beaten by a cartel if drugs had been legal(ish) in America? It is reasonable to say: no.

Authoritarian states beating their subjects has nothing to do with him being beaten in the streets that night.
I just bought a new Pixel 3a only to find out that my cell provider locks the bootloader until I've paid for 3-4 months service with the phone, despite previously having an account with them.

This was not mentioned at any time during the purchase and they would not take my phone back.
Thinkspot – The Free Speech Platform
I'm the guy that if you're in the line at walmart with me, I'm going to start talking to you. I've met some down right interesting folks this way. I also travel for work a lot. Talking to people in the hotel lobby is one of my favorite hobbies. I've met CEOs, truck drivers and people on vacation, all of them really interesting folks.

Everyone has a story or a piece of advice to give you. Just ask.
Chrome Tracing for Fun and Profit
I don't know if they are even-handed or not, but is there a reason they need to be?
Hi from the Apollo team! We hired a mobile engineer who is starting within a few weeks. Keep your eyes out for lots of exciting improvements to Apollo iOS soon!
Well I mean they gotta tell the brass they are doing something, right? So you create an atmosphere by where it looks like you are doing stuff, but really you know the things you are doing are ineffective and even counter productive to your goals. But you need a job, doesn't everyone? So the cycle of a bumbling war on drugs goes on.
Yep. My first thought was "Genius". It's like selling shovels to gold prospectors.
The latest podcast from podcast.__init__ is an interview of Meredydd about anvil

https://www.pythonpodcast.com/anvil-web-application-developm...
All the Women in This Photo of “Tech Titans” Were Photoshopped In
Hopefully that will improve with the newly announced version for Windows...

https://arstechnica.com/gadgets/2019/06/apples-new-and-impro...

https://blogs.windows.com/windowsexperience/2019/06/11/apple...
This is right-wing rhetoric from people who seem to think the solution to homelessness is to throw them all in jail. Wait sorry, they don't have the "perfect solution," but they're certain it involves police and jail. And they're sure all the homeless people moved here from elsewhere, despite the data to the contrary.
Calm your tits, Jew.
haven't seen an engineering shop in a while that didn't offer macbooks to engineers. At least 8 years. Internally at Google for instance almost everyone is on a macbook.
Memo, Unix-style note-taking software
What kind of workflow requires so much power? I haven’t touched audio in a while, but back in 2012 I could already comfortably run layers upon layers of processing per track, I would have imagined any current processor is more than up to the task.