skysight-inc/HackerNews huggingface dataset:
The main priority of these medical and genetic companies is to make money. Safety, ethics and privacy are secondary until they effect the profit. It seems increasingly apparent that public funding and open source efforts are required to advance the science, healing and education of our planet.

DNA SNPs are one thing, but genetic expression (phenotype) is immensely complex due to the number of variables. For example, mammalian immune systems are highly redundant across the body and continually signal with cytokines and chemokines to manipulate the immune response that is internally/externally environment dependent.
Our bodies continually work to remove/detox OR sequester pathogens, toxins, metals, etc. This usually results in isolated and/or systemic inflammation across the body. Many of the pathogens manifest with overlapping symptoms making it hard to isolate without better diagnostic tools. For example, my two strains of Bartonella cause inflammation in many similar areas that Lyme bacteria do and Babesia has another similar set. It is hard to isolate those symptoms from the mold toxins and metal (aluminum, arsenic, lead) buildup that I also have. Functional doctors believe the HLA SNPs play a role in accumulation rather than removal. Enter saunas/sweat tents/etc that many cultures used for centuries (lymphatic detox).

Enter public funding to invent better and cheaper measuring equipment where each of us owns the data. Privacy protection is also important. We live on a planet with immense biodiversity, albeit shrinking daily due to human activities, where we coexist with bacteria, pathogens, molecules, industrial toxins, etc -- It's time we start to learn more about everything ... gathering data in a coherent schema and applying ML can certainly help.

That is why there are a number of studies that list various pathogens in brain deposits for Alzheimers, MS, Giant Cell, etc -- Feel free to google and research many of the terms above and reach your own conclusions :-)
all i can go off of is my own experience. i can’t think of any other consumer electronics that have just outright failed like my apple products have. it is significant. and no one else is claiming those other products are built better than everything else, which is part of my point. apple markets and hypes themselves like no other company, and people just end up repeating what apple says, where apple gives no data to back up their claims. they just state it as fact, and yet, in many people’s experience, apple products fail just as if not more often than other brands.

and you are missing the point as well that many of these issues on the apple products are long standing issues across multiple iterations of them. just search bluetooth audio not working on macbook pro’s (iPads and iPhones have been fine in my experience). it is specific to them. and again, i have never had a single issue with other bluetooth devices and audio. (there’s an interesting issue too with bluetooth headphones. for certain bluetooth headphones, mac os x will automatically open itunes upon connect, and there’s nothing you can do other than having to go through a convoluted process to basically rename itunes so that it doesn’t get launched. this isn’t “just works”. and again, pointing other issues with other brands is irrelevant because it is apple that is being claimed as robust and always working.)

and the branding thing is still not addressed. my lg v35 is every bit as good as my girlfriend’s and brother’s iPhone xs max and even has major features the iPhone doesn’t have, and yet, it was almost half the price. you can’t explain that any other way than people pay apple for the brand.
My Candidate Description(why you should write one)
they have to mail it to you
Lupus has been shown to have a correlation with gut biome balance as well. [1]

It makes sense though, certain bacteria's feed off of the sugars in our gut and release harmful chemicals. Beneficial bacterium do the opposite.

[1] https://ard.bmj.com/content/early/2019/03/01/annrheumdis-201...
There has been a lot of research that points to the brain acting first, then justifying whatever actions it took.

I believe this to be the natural state of affairs. I think the brain is as maximally lazy as it can be. This translates to clanning with a large-ish group of people, then trusting that group to make a good collective decision. Act immediately on social observation and emotion and then if absolutely necessary come back and revisit the action to figure out "why" you did it.

If this is the way it works, then the default viewpoint regarding anything we do or say should be highly suspicious from a rational standpoint. It also means that we tech folks have spent a lot of time and effort trying to create artificial intelligence that reasons from logic to action, the complete opposite of the way real intelligence works.
Pocket for me too.
Wish I could use Notion for this (I use it for many other things), hope they release their Firefox extension soon.
Look at the Google/Oracle case about their replicating of the Java API. There was significant debate over whether they made a clean room implementation or whether they just copied Oracle's code.

If you could stand up in a court room and truthfully say "I've never seen the source code I am accused of copying" it would be to your benefit.
99 - < 20ms

99.9 - < 90ms

That is amazing.
How does it prevent someone whom knows the password from resetting the clock?
If you think Skype is bad, you should try Skype for Business.

Microsoft really don't care about its customers if you judge it on that application.
Health insurance discrimination using genetics illegal (GINA), but life insurance and long-term care insurance is not.
Says the news report from the west's surveillance state...
I love reading about Google's systems, but I wish I could work on those problems at scale, that is my dream really. I wonder what more systems Google has that we don't know about.

I know Borg has become what we know as k8s but surely there must be more things that Google has made internally that are not open source.

Curious about this and would like to know more about it from anyone in the trenches at Google.
Certainly, everyone is entitled to use whatever license terms they wish.

I don’t consider that a solution for the ethics problem, though. What’s good and what’s evil is a very grey area. Ambiguous terms don’t make a good license. Most people consider themselves good. Many Facebook engineers consider themselves good, I’d wager. Does that make Facebook good? Russian intelligence officers probably consider themselves good. Does that make their use of JSlint good? Even Nazis considered themselves good. The entire ideology was centered around that narrative. So how can a license using those terms solve the ethics problem?
AFAICT there's no universally agreed upon meteorological definition for "code red day." Rather, this is just something Sinclair made up for "risk of severe weather." A "code red" is also used to refer to air quality[1]. And fire risk[2]. There's also the CodeRED alert system[3].

So since this is just made up by Sinclair and doesn't have any technical definiton, what's this guy complaining about? This is Sinclair after all.

1. https://www.education.vic.gov.au/about/programs/health/Pages...

2. http://voices.washingtonpost.com/local-breaking-news/dc/3rd-...

3. https://www.onsolve.com/solutions/products/codered/
Copycat Art Scratcher – Mona Lisa
>In retrospect this shouldn’t surprise anyone

It doesn't, because it's not news. The article mentions

>Previous studies have found high levels of mosaicism in the skin[2], oesophagus[3] and blood[4].

Then novelty is the scale of the experiment, not the insight.
I do wonder how long it's going to be before we see WhatsApp and the surveillance state articles.
why image assets are necessary with modern application? We should be using vector images by now. And vector images are tiny.
1. Genetic nondiscrimination laws are under constant attack (GINA, the most comprehensive, faced significant weakening this Congressional session - fortunately, it appears to be on the back burner for now). That's in the US. Canada has significantly less genetic privacy legislation, and the Trudeau government is negatively disposed to that which currently exists.

2. There is no such thing as anonymous genetic data once you move past extremely small SNP panels. Even if the data is pooled.
The pointy shoes are a shibboleth. They identify a group not despite their impracticality but because of it. Another example is the belief in miracles, the more unlikely the better, because it is the absurdity of the belief that distinguishes you from unbelievers.

There are oodles of such shibboleths in modern times, particularly in politics. Just think of any political proposition that is absurd on its face and more absurd on reflection. If it's still widely supported by a particular group that may well be because of its group-identifying absurdity rather than despite it.

But it is often not a scam of any kind, but sincerely accepted by adherents. This kind of cognitive flexibility goes a long way toward explaining modern politics and not so modern religions. I suspect pointy shoes may have been the same, with their wearer's convinced of their inherent value.
Created 6 months ago; first comment.
Accessible Icon Buttons
Why so harsh?

This isn't production code published by Microsoft, it's an "enthusiast's take" written by a student learning to code. Most of my college colleagues couldn't make it through FizzBuzz.

Hopefully a bright new programmer doesn't get discouraged by getting smacked down in the top comment on hacker news.
should we ban wechat? probably yes. it's a quintessential threat to privacy, freedom, and democracy practice.
but are we able to? not at all. All big corporates and even some in government are on their side. China is where money is to make and ruling is to learn.
i use glue traps all year round, catches tons of bugs and mice. once it's full, just toss it.
They are definitely not random. Sequence context matters a lot - e.g. in humans CG mutates about 10x more often than other dinucleotides. Other contexts also contribute - genes that are expressed more are more mutable, and so on.
The USPTO doesn't agree with you. [1] More likely the examiner considered it "suggestive" which can be trademarked if it's well-known. At this point it is even incontestable. [2]

[1] http://tsdr.uspto.gov/#caseNumber=78893436&caseType=SERIAL_N...
[2] http://tsdr.uspto.gov/documentviewer?caseId=sn78893436&docId...
Random Machine
I didn't know there was a connection! I wonder if the US highway shields also somehow kept an "older" design language while in Europe things "progressed" more easily to more modernist forms.
According to

https://qz.com/268852/neal-stephensons-failed-500000-video-g...

that's backwards: the problem with CLANG was not its implementation, it was that the result was a boring game.

As for implementation, consensus among those who've bothered to look at the original Bitcoin code is that it wasn't very good, most likely not the work of a professional programmer.
On the other hand Google engineers are vendor-locked-in using Google specific tech one way or another.
> it's safer (for the occupant, less safe for others)

The data usually cited for this is studies showing that it is safer in given collision conditions. On the other hand, collisions are more likely, rollovers are more likely, and rollovers are disproportionately fatal for vehicle occupants compared to collisions.
In the UK credit scores have been tied to social behaviors like voting. Similarly London has been famed for their CCTV system that allegedly keeps crime low. And let’s not forget the CompStat database system that is credited with turning NYC from one of the most dangerous western cities to one of the safest. My point is, that at least within the time range of cheap genetic tests, these “totalitarian” systems have already been in place.
Unfortunately those APIs seems to be kind of obsolete nowadays. All the nice things are with UWP. I think that WinAPI is not even hardware accelerated. That's a pity, but what can we expect, when Microsoft themselves botched WinAPI in their own products long ago.

Windows could be so better with their old Windows 2000 style, without all those design jumps around.
Those shoes were also useful for lifting the ladies long dresses, making them very practical at parties.
Well worker rights is a fantasy in the west too.

Google and facebook track our every moves and the NSA can watch over our every move. The scary thing is few journalist are left to talk about it over here.
Analyzing actors with face recognition in Tarantino films
There's absolutely a movement for people to keep house cats inside because they maul grounded bats and other small animals they don't intend to eat. They're also at risk of getting hit by cars, eaten by coyotes, etc.
I was born in one of ex-Soviet republics and lived in Russia for a bit in the 90s and on one hand I'm surprised that people tolerate this level of bullshit, but on the other hand I can see why they do. Russian government basically needs to ensure that the quality of life is a tad better than what it was in the 90s to keep most people docile. Russians have been through so much shit that they can endure anything and the government is basically taking advantage of this and does whatever it wants in plain sight. This absurd submissiveness even has its own term in Russian - Vata (literal translation is cotton), which basically implies you're so soft, submissive and brainwashed that you ultimately don't care what happens to you as long as your basic, fundamental needs are met. However, the new generation of Russians is completely different and have no interest living in stagnation, deprived of future for themselves and their children, but man, the wall is so tall at this point it's hard to see what they can achieve. I really believe that not much is going to change in Russia until the Soviet generations die out, as sad as it may sound.
My dad's method for getting rid of mice was one solid blow from a 2 quart sauce pan. I think I was 4 when I first saw that. It's an ugly thing to take a life, but at least it was quick.
The lack of keyboard shortcuts and tabbing means any setting I have to change repeatedly is a bunch of hard-to-automate clicks. (Namely, plugging into a new monitor and rotating it, since the Ctrl+Alt+UpArrow doesn't work any more.)
Inky's Daring Escape Shows How Smart Octopuses Are
Also worth noting: this is further evidence that cancer, like many other diseases, is in part an immune disease.

When central tolerance is too lax, tumor cells can more easily survive a trip through the bloodstream to seed metastasis (the eventual cause of nearly all cancer deaths, aside from treatment sequelae and thrombosis).

By contrast, if central tolerance is overly tight, then you see autoimmune diseases (severe aplastic anemia is a classic example) where the immune system wipes out the competition from healthy progenitors, and mutant clones better able to survive the onslaught seed cancers. This is one reason why both immunosuppressive therapies and immunostimulatory agents can both increase cancer risk.

It’s also worth noting just how different the mutational profiles of pediatric tumors are versus adults. To grossly oversimplify, peds tumors tend to carry mutations (typically gene fusions, amplifications, or deletions) that confer a developmental-stage-specific advantage in proliferation, such that no normal progenitor could ever hope to keep up. By contrast, the most frequently observed point mutations in adult cancer (to TP53, in particular, although DNMT3A in leukemia is another example) confer stress resistance to the mutant clones. They are nearly absent from tumors seen in children. Even Li-Fraumeni syndrome, where people carry deleterious TP53 variants inherited from their parents, does not begin to show a huge risk differential until adolescence. So there are evolutionary, developmental, and immune differences that shape the genesis, selection, and growth of different tumors in different age groups, and tend to indicate different treatment.

The standard chemo regimens for pediatric ALL (acute lymphoblastic leukemia, the most common cancer in kids) would kill many adults, and despite over 90% cure rates in kids, far less than half of adults with the “same” disease will survive it. (In quotes, because as with every other tumor that spans the full range of age groups, the drivers in adults are different from those in kids for almost all instances).

Similarly, immune checkpoint inhibitors can generate miraculous responses in adults tumors, though these are seldom seen in pediatric patients. With the benefit of hindsight, it’s more obvious why this is so (the random accumulation of mutations over decades in adult tumors is more likely to generate immune-recognized non-self proteins), but it took a long, long time to get here. (Look up “Cooley’s Toxins” if you think immunotherapy is new :-/)

I still find the fields fascinating, despite having enough ghosts on my conscience to stock a mausoleum. Cancer is part of our evolutionary heritage; the best we can do in adults is usually try to control its spread and cut out enough of it for the immune system to mop up the rest. Kids are different, but that’s another story for another time. It’s a great period in history to be working on understanding these things and they interact.
> I imagine you have some role in building the internet since you're on HN.

I do. I sit in a tiny corner where we just build websites without all that JS and tracking bullshit. (That's not to say that I never use JS, I just use it very sparingly.)

It's just a different philosophy. I don't need to know how many people exactly listen to my podcast. It's much more rewarding to me when I meet random people and they say "Oh you're that guy? I loved your last episode." That's 100 times more awesome than seeing a download counter increment.
It’s not manipulation. They mention the price difference on their website:

https://help.barnesandnoble.com/app/answers/detail/a_id/3265...

Beyond that, the in-store price is considered to be the “normal” pricing. You are getting a discount on the website.
Yes.

In a wider sense, you also want to explain why something is NOT done. Ie why certain other ideas don't work, or why we don't offer certain features.
There is practically no difference in these requirements versus what Facebook is requiring. Try to create a Facebook account and they will soon flag your account to require a photo for facial recognition. You can't signup for Facebook without a valid mobile number. And if Facebook does not like the photo you provide for facial recognition, they want a government ID.
Books Reclaimed from Nazi Fires
Consider that the washington post was purchased for $250M. That was about four months current revenue. Admittedly Make Magazine is great but probably not pulling in $700M annually.

If they could have convinced a "famous tech billionaire" to purchase Make as a vanity project / property ...
There's a YouTube channel that features old and new mousetraps. Some of them are 3D printed and work just like the one you mentioned: https://www.youtube.com/playlist?list=PLQv9MGcwQg4uVfQl2ZvPu...
99%? Do you actually believe that?
So you're arguing that non-eastern vegans lead a "sick and foggy half life"?
Seconded. From the author's linked blogpost about the model, it seems like they've trained a similar analogous model, but I see no reference to metrics that might suggest it's really of the same quality.
Companies retain ownership of their code regardless of where a copy ends up because of a legal framework that defines it such, not by default. DNA, fingerprints, et al. need such framework too.
Interesting point of view. That'd explain flat earth and other oddities.
All the Hype with Stable Coin and Facebook’s GlobalCoin Explained
Cracks in nuclear reactor could lead to the evacuation of Edinburgh and Glasgow
That gives you all the history (or all the history of a file).

Git blame quickly gives you the commits you are likely interested in, then you can use them as a starting point for your git log digging.
Breakthrough solves the famous Schrödinger’s Cat paradox
Nice to see some sane, compassionate comments here to balance out the psychopaths who can't even empathize with a mouse.

Weird how people always seem to brag about how little empathy they have for animals whether it's a submission about glue traps or Beyond Meat. Though you usually need showdead=true to see them.
Two counter examples:

1. A cpu you rely on is a well understood system yet unexpected failures do happen (eg pentium bug, spectre exploits, etc).

2. A human you rely on might fail unexpectedly (tired, drunk, heart attack, going crazy, embracing terrorism, etc).

After testing reasonable number of things, if NNs perform more reliably than those other systems we rely on currently, it will be increasingly harder to justify using the other systems, especially when that means more people accidentally dying every year.
NPCollapse, do you have any metrics on the quality of your replication? Without any mention of metrics in either post, I'm skeptical that you've really replicated their results, which would render everything else rather moot. As you said, trust is hard.
Agreed. It gives you a rough idea though. They're statistics from the UN btw.
"Los pollos (...) están programados para ser sacrificados (...)"

BTW, that's some awful Spanish.
It reads like the chicken were robots programmed to be sacrificed because
the subject of the scheduling/programming was inadvertently changed from
the slaughter to the chickens :P
If the signer puts their key on a build server and that build server is hacked, then the signing is worthless. (Although, having written this, I suppose people would just put their TOTP secret on the build server also)

With a centralized registry model I already trust the registry anyway. It’s not like I’m typically going out and verifying people’s keys by emailing them to check what their real key should be or whatever.
If emissions cease completely then there's much less need for the prize fund. The point of the prize system is that it avoids the government picking winners. The money is distributed by objective measurement. But admittedly "net removed carbon" (meaning carbon removed from the air - carbon released into the air by the removal process) has some subjectivity in the "by the removal process" part. What qualifies as part of the process? This problem could be avoided by limiting applicants to countries with the fossil fuel tax + import tariffs, and judging purely on carbon recovered.

Just reducing consumption is not pulling carbon out of the air so it would score zero, and it's a highly ineffective solution (we've been trying it for decades, but CO2 levels keep increasing).
There was an article on here a few months back that said something like, "The majority of today's applications of AI could be just as well - if not better - served by a simple heuristic"
We all have tiny little cancers right now. Our bodies are constantly producing mutations that disable growth regulation, promote proliferation, change cell adhesion, etc.

It's just that our body is programmed to defeat these irregularities and disease states. The immune system is a major component, as it can recognize cell surface epitopes of a variety of types - mutated ones, or even suicide signals. Cells that detect that they have entered a disease state will often enter apoptosis or tell their neighbors about it.

We get cancer when cells accumulate so many mutations that they not only grow unchecked, but they also evade the body's natural forms of detection and clearance. And then they eventually hill climb into a state where they leave their original tissue and move about the body uncontrolled.

You evolved to defeat cancer. It's just a numbers game until one of your precancerous cells accumulates enough mutation to escape capture.
That is a valid observation and completely orthogonal to the point being made.