skysight-inc/HackerNews huggingface dataset:
That's a good point. A couple things to add:

- startups that license potential molecules from academia often do a lot of discovery work. Academics generally do some of the target validation / biology, but dont usually produce optimized drug-like molecules. Most of the expense of drug discovery is actually screening compounds against a validated target (and validating the target), filtering those for potential leads, and then extensive chemistry work to get a development candidate). In the OP, drug discovery is target-to-hit + hit-to-lead + lead optimization. Most of this is done by startups, not academia

- the cost of capital is higher for startups than big pharma. big pharma companies generally have cost of capital around 10-12%, whereas for VC backed startups, cost of capital is like 20%+. this has a huge effect on valuation, and on the price companies must eventually charge for drugs to generate a return that attracts investors
If you had any idea of what the "data" behind most of these warming claims generally consists of, and which is used to generate the relevant peer-reviewed research papers, then you would probably hang your head in shame.
Dating is all about risk. If you can't hit on your client, then what about the person at the grocery store? What about at the DMV? What about on the street?

If we eliminate flirting from all the places it's unacceptable, then there wouldn't be any more flirting at all. Considering it's generally the man's responsibility to initiate (cultural standards, not my own, I would love if women took this responsibility), this really just negatively affects men and not women, furthering the inequality in dating.
Americans as Concerned as Ever About Global Warming
There's a 3rd option not being given attention here: adoption. Why play into the idea that the fate of the future depends on some contest to reproduce more "good guys" than "bad guys"? There's plenty of kids that need families who, otherwise, may become the very "bad guys" you speak of. At the same time, you're not further burdening the world's ecosystem with another human simply because of a selfish desire to have another "you" out there. Sounds like a win-win to me.
I agree and it really does blow my mind how powerful their service could be if fully utilized as an internal intelligence gathering tool.
Why GOG Suddenly Fixed a 13-Year-Old 'Far Cry' Glitch
Never underestimate the power of a properly configured server with 1TB of RAM running MySQL off of SSD.

In my experience, people used to cloud services misjudge the power of correctly tuned modern hardware by two-three orders of magnitude.

Giving a general answer to your question is hard in the absence of further information.
One example of #4 that is making headway in production systems is the Calvin protocol (a RAFT based write-ahead-log with lock-free deterministic transaction application). It's implemented by my employer FaunaDB. You can learn more here https://fauna.com/blog/consistency-without-clocks-faunadb-tr...
Building software wasn't what I was talking about. They've obviously done that.

I'm talking about the sheer amount of software and people that support those efforts now, in addition to how much profit comes from it. Surely it has grown by more than say...5x.
> It's such a good idea that the US government decided you were right decades ago.

Perhaps, but it is hardly a universal belief that they have the balance right.

It is hard to pick a starting point to get in to this discussion, because it has been going on for a long time and is really complicated, not to mention largely classified. Perhaps one that dovetails into the encryption debate will be as good as any:

https://www.lawfareblog.com/good-defense-good-offense-nsa-my...
For the cases you mention a combination of package name, class name and method / function name could serve as a comment with the benefit of making sure any place referencing the code also "documents" why something is happening (tests for example, or callers of your methods).

This is not always possible, and in those cases I also strongly prefer well written, concise comments explaining what is going on and why, ideally with a link to a reference/source which explains the background.

Some examples of method names:

- generateTreeToAllowPartitioningOfItems(...)

- getMatchingRegularizationPenaltyForSpecialCaseX(...)

- getShortTermRedisProxyCache(...)

- createNewPrefilledTemplateObjectForXYZ(...)

I hope this doesn't sound snarky. But more often than not comments do date in my experience (and they don't handle refactoring well), while (compiler-known) names are handled as 1st class citizens by the current IDEs and thus are corrected and updated anywhere.

In code reviews we usually aim for "low comment" density, the implementer shouldn't explain what or why he was doing, the reviewer has to understand just from the code (as it would happen if she/he has to maintain it later on). The review is "not good" or even fails if the reviewer doesn't understand why and what is happening. The outcome will in most cases be an improved design, not more comments.
You aren't a senior developer until you are a senior citizen. The arrogance of a 20 something thinking they are senior programmmers! No, you are babies still.
Absolutely nothing: the problem cryptocurrencies solve is allowing mutually distrusting parties to engage in transactions.

The only potential advantage of such a system over an RDBMS is the inability to reverse transactions without people taking serious notice, simple git-style hash chains generally solve this too, often with reduced overhead.
Note that donations are used exclusively for Foundation efforts; donation money is not put toward product development.

(The Foundation is a great cause, obviously, but I want to ensure that you are aware of how your donation will be used.)
Amazon Pressed by Key N.Y. Democrat over Plans for Small Vendors
Unputdownable: The bookshops Amazon couldn't kill
I wouldn't be positive about that either. It could be that both are true, and create a virtuous cycle.

Or it could be that neither is true, and it's really that both characteristics are engendered by having a curious temperament.
Which is why I am trying to get better at what I used to to: writing down and sharing problems I saw.
This supports what I've always wanted in a markdown note taking app...

being able to directly copy and paste an image from the clipboard.
My dad's small business construction company was called "AA1 Construction" because he wanted it to be the first in the phone book.
Not at all!

It is normal to be connected to multiple servers at once, and the UI makes it easy to keep track of them.

As the other commenter said, it is much better to think of each server as a channel. A Discord server is typically dedicated to a single topic or organization. My old World of Warcraft guild has a Discord server. On that server, you'll have separate channels for general chat, announcements, and several voice channels for groups.
Before smartphones monopolised the market, there was a good variety of handsets to choose from (still is if you look at things from a hardware perspective).

Same was true for micro computers all throughout the 80s and up to mid 90s.

Games consoles, cars, TVs, laptop OEMs, enterprise cloud hosting providers, etc.

So plenty of counter examples.
" There is no point to buy or use it because it solves no problems for regular people."

I disagree with that statement. It does solve the problem of getting paid through facebook (which a lot of people do and use). It surely promotes and carves Facebook deeper into their lives, but it solves a problem.

Im not for this offering, but its not hard for me to see why it has a chance of mass aadoption. Hopefully it fails.
So it's a cryptocurrency that's basically the equivalent of a gift card or Chuck-E-Cheese token? How is this different from in-game currency that isn't backed by Crypto?

Seems that FB is just riding the buzzword wave.
For me on Windows that quick command-line calculator has been PowerShell for a while.
Clearly I'm no expert in the field, but I've no understood the objections to group selection.

From what I've read, the objector claim that genes get selected and this slection necessarily passes by reproduction which is done on an individual basis.

Yet, especially inthe example of ants, two neighbour colonies of ants of the same specie might have a queen with different genes and if the difference grant and advantages the one with the better gene pool with spawn other similar colonies which woudl supplant the inferior one. In each colonies, non-reproductive ants with the better gene don't reproduce themselves but yet it's their better genes that supplant the neighbouring colonies. The queen does no work other than lay eggs, so it does not not contribute the the higher success rate ofthe colonies. Clearly, the behaviour of non-reproducing ants has a direct influence on the gene pool.

For example, the better gene might make better warrior ants. They don't reproduce themselves, yet the gene helps the colonies.

The same argument could be made of two wolf packs, or any two competing group. Of course, in those case, you can look at it at an individual level, but the better gene will sprad at the group level. (Ignoring if a wolf could switch pack to spread the gene to the other pack. I'm here assuming this doesn't happen for the sake of the argument.) The more social the species, the more the group-level genes can influence the chances of reproductions of those not harboring the gene but part of the group, which make the group more successful, which eventually will make the gene spread in the group through gene exchange and selection during reproduction. For example, if the gene leads to better caring between individuals, it benefits the entire group harboring individual with that traits and eventually the group with the highest percentage of that gene will win out.
Load the remaining customer funds into RAM, and decrement them on each API. Periodically flush the remaining balance to DB at set intervals (say every hour). If the server goes down, well, your customers got free API calls for an hour to compensate them for their trouble. With any reasonable uptime you'll save more on DB traffic than you lose in lost revenues.

(BTW, the "can't reply" issue happens on HN when there's a long comment thread between just two people that's being rapidly updated. If you wait 10 minutes or so you'll be able to reply.)
Because funding costs for hedging cross currency trades have gone up ever since the Fed has started raising rates and largely reduced returns or in some cases even caused negative returns. Funding costs have exceeded rate hikes 1:1 and this has caused the foreign buyer base to drop sharply for UST.
I was about to say the same thing. Some light novel titles are literally a long description. These are two of the longer titles:

* (I've Already Saved This World and Taken Its Wealth and Power and I Live Happily in a Castle with a Female Knight and Demon Queen, So To All Other Heroes) Stay Out of This Fantasy World.

* Sew It Up! Take It Off? Change!! My Girlfriend Failed Her High School Debut and Became a Hikikomori, So I Decided to Coordinate Her Youth (Fashion)

You also see the same trend with some manga titles:

* I'm a Middle-Aged Man Who Got My Adventurer License Revoked, But I'm Enjoying a Carefree Lifestyle Because I Have an Adorable Daughter Now

* A Story About Treating a Female Knight, Who Has Never Been Treated as a Woman, as a Woman

Indie publishing has also made high quality cover art much more important. I don't know about other people, but I regularly judge books based on their cover. There was a book in my recommendations list which I skipped for years just because I thought one of the guys on the cover looked like an asshole. Ended up enjoying it and regretting that I waited so long to pick it up. This isn't always the case, but more often than not, low quality cover art means poor writing as well.
In other words, it's not pumping blood.
New AMP Issue Detected
I suspect the answer is micro transactions.

No one has figured out how to do it at scale using USD. Cryptocurrency theoretically offers a solution, but is still mostly unproven.

Whoever figures it out could potentially save the news business.
FWIW, I'm not sure that a curious temperament is materially different from intellectual humility.
So here's a rant on the topic picked at random, discussing loss rates to employee theft in this business on the order of 20% (and that's with tokens!): https://frank-thecrank.com/are-you-losing-arcade-business-ga.... The same rant puts the base level of 'walk-away tokens' (the condition you describe) at 0.5-1% of the total.
It must not suck if more and more are using it and talking about it.

I use to bang google fairly frequently when I first started using it but my use of that command has become a lot less; now 10 to 20 percent of the time.

I don’t hear ppl talking about Bing. Also I hear people talking about privacy including Apple. It’s now seems to be apart of their branding and those who are on the same bandwagon I’m sure will find continued success.
Owf.

Alright side stepping that barrel of worms, it still is the law until overturned.
i made my first 10€ at the local fair.
they offered food on a plate and wanted a 1€ deposit for the plate. people are lazy and dont want to wait in line to get their deposit back. thats where we got in. we just took their plates, offered them their deposits and most of them just said "keep the money". the view of a bunch of 8 year olds with 10 plates each at the deposit station must have been glorious :D
You Can Now Search the Full Text of 3M Nonprofit Tax Records for Free
While I cannot 100% agree with 0815test's statements (mainly because I don't see discussion as a win/lose battle, counting points, cutting losses...), there is in fact a certain motivation to take the stubborn position. When you look at the real world examples of people who successfully spread their ideas, unfortunately quite often there will be a certain degree of stubborness. It might be called different names - determination, believing in one's goals, but the effect is the same - at a certain point they will refuse to accept an alternative idea, even without any hard data. And by doing that, they might earn a social position that allows them to spread the ideas among many. Sometimes they even turn out to be right, sometimes not, but it was the aura of close-minded belief in themselves that brought them followers. Honestly, I'm a little disappointed that it works like this, because I would really prefer if deliberate polite factual discussion was always the norm.
The commenter I replied to left out this important detail that is also somewhat buried 3/4 of the way into the letter. Definitely read her original statement and form your own opinion based on the source material.
I have been in this situation and tried to remember what was going on while I wrote the questionable code. It frequently came down to a day full of interruptions and context switching. Also motivation plays a tremendous role, I know that whenever I have to work on a code base I don’t understand and don’t want to have anything to do with it long term, it ruins my ability to focus.
https://xkcd.com/610/

It can be a bit uncomfortable to realize that what we think of as "us" these thoughts and feelings we internalize and think of as unique... aren't so I can understand some resistance to recognize the depths and thoughts of others... or being like everyone else.
Worth noting that Maker is different than those other because there's no central authority holding fiat money to maintain the peg. Their stablecoin Dai is minted "out of thin air" and the price peg is maintained via an interest rate mechanism built into the smart contract.
Agree with this. I obviously comment on bugs and also convoluted code that I know will be hard to understand later. If it is just small details it is easier to just change them myself when I inevitably have to revisit the code later on rather than nitpicking and arguing during the review. If I don't have to revisit the code for any change then just let it be. Out of sight, out of mind
A striking, joyful portrait of America's greatest divide
Or bash, just $((1+1)).
I think it would be more like prior art, to distinguish originals from copies rather than to authenticate the content itself. Given two pieces of similar-but-different video the one with the earliest timestamp is presumably the original.
The behavior is predetermined. What is intriguing is that so much complex behavior emerges from simple rules.
You think we'll stop doing that in 2-3 years?
BlackBerry had a duress password feature to secure erase the device in the event of said password being used, and it would brick the device in the event of being aborted (battery pull). Wouldn't that be considered destruction of evidence though?
Supreme Court ruling define what the constitution means and applies to.
US really need to deregulate (btw I find this word an oxymoron, but english is not my first language) their ISP's and most countries really need to deregulate their wireless providers.

Imagine single shared spectrum easy to setup eSIM, easy to terminate contracts. Unfortunately most countries want your ID nowadays when you sign up for internet...
I think v1 of these phones will be disappointing, but promising. If the projects survive to launch their v3s, I’ll get excited.

If anyone on their teams is reading, the deal breaker for me is this: I need Authy, or an equiv, and Anki. Also need a step counter and my password manager to sync across devices easily. Probably slack too. Phone and texting also, but honestly the web browser would be secondary. Maps could be optional.

If a new phone could provide that, I think I could safely buy it and be able to use it as a daily driver.
If the iPhone did not have Netflix and Google Maps then less people would buy iPhones -- so its not really that straightforward. While the argument works for small businesses, larger businesses might be in fact bringing hardware revenue to Apple.
Oh hell, I was excited until I read this "Team: Facebook’s blockchain project is overseen by former PayPal President and VP of Facebook Messenger David Marcus." I just can't see leadership being good for Crypto if his tenure at Paypal is any indicator.
That's a good point. There will be prioritization, and the costs could be so high as to rule out brand plays even if they could get the rules interpreted as loosely as possible. My idea might need to bake a bit longer. :)
Agreed. HIPPA is not exactly a promising precedent.

Regulation would almost certainly lag at least a couple years behind and end up making software and IT maintenance much more expensive without making it that much more secure. I don’t think I like this idea, but imagine if marketers for more robust, secure IT solutions were legally allowed to show you how they can spy on you as a part of an ad. That opens up a huge can of worms that is probably best left closed, but I think it’d act like steroids for getting people to upgrade their insecure stuff.
Every person whose face appears on COPS has signed a release allowing this.
I actually found an OS bug in AIX on my first real I-designed-this code project. Worse, the bug was discovered only when the code went into production - it behaved differently on the test servers than on the production servers! The bug caused mmap() system calls to randomly overwrite certain pages in memory with NULLs. Yeah, that was fun. And it was caused by the order in which patches had been applied, which was why it behaved differently in production than in dev/test.

If some second year programmer told me that nonsense, I'd make them go back and either find their bug, or write a test program that exercised the bug in isolation (which was what I did).
Except GFW always check the traffic and likely 1) DNS poisoned, 2) TCP RST'ed some of the misrouted traffic?
When was driving considered a right?
STEMlab – Swiss Army Knife for Engineers
They have one in Sydney. Only European and North American countries were listed in the launch announcement. I'd expect Australia and Asian countries, where Google have data centers, to follow some time later.
Who's to say it won't go to the University of Texas, or some such institution?
I try to avoid the word "design" because most people immediately think of graphic design and get the wrong idea of what I do. Even though it's not as technically accurate, I think "building" or "engineering" are better words to use for people not familiar with software development.
Wouldn't it be rational to wait for my competitor to take you up on that deal? Then I could spend the extra money on research that only benefits myself.
Just to add to the "ignored the internet" bit:

This is the company that had "the dot in .com" as its marketing slogan.

https://www.youtube.com/watch?v=njnNVV5QNaA

https://slashdot.org/story/00/04/20/1542217/sun-no-longer-th...
On the plus side, this means that a website operator of a low-profit topic can still earn a living.

When I was blogging a decade ago I would write almost exclusively about finance because it paid the best. With this system, I could write about other topics and still capture some of that finance-context revenue.
Have we really reached the point where HR departments decide which email provider to use?
See also: http://runeberg.org/folkeven/
What part of Alabama do you live in?
Outstanding observation, thank you!
Please define your understanding of free speech and hate speech. The vox double standard to insult and humiliate others who don't agree with them is at this point a meme itself .
How is this not a violation of (one of) the four freedoms?
Just thinking out loud here but the particular case of inventory of an item should be possible to decrement/increment using a PN-Counter CRDT as long as you are fine with eventual consistency. Of course there's a risk of overcommitment which has to be considered but such risks usually exists in commerce any way due to or factors.
I work on provisioning tools, I use all of them. I've definitely seen GKE take just as long as the others...
I love that they are doing this, but I am worried it may not be enough to keep the ISS up past 2024, but it is a good first step.

Some context for those that haven’t been following closely:
It costs NASA over 4 billion a year to maintain the ISS. [0]

While the vast majority of that cost is transportation to/from the ISS (around 2.4 billion), there is a sizeable chuck that if they could “offload” to the private sector, may allow NASA to keep the ISS in orbit longer than currently planned.

The problem is, at least until they grow a true market, that market isn’t big enough to support that maintenance.

So, I believe the strategy (which makes sense) is try and get a true market/interest in the ISS going. If they can do that successfully, it should lower the cost for everyone, potentially allowing for even more things to happen in LEO.

So we will see, but I will note one of the biggest risks for SpaceX/Blue Origin/others doing commercial resupply is that once ISS disappears, there is no ready customer/market for their commercial offerings for crew. No way faster to kill the infant commercial crew space industry than to starve it of revenue.

[0] https://www.nasa.gov/sites/default/files/atoms/files/fy_2018...
It is a numbers game. It is basically free and if you get 1 in a million than hey that's money. Same with Nigerian email spam I suppose.
One of the first rules from the book The Pragmatic Programmer is "SELECT isn't broken". (It might even be the first rule.)
Sarah Constantin's essay on plow cultures and hoe cultures seems apposite here: https://srconstantin.wordpress.com/2017/09/13/hoe-cultures-a...

(Note the very first photo in the wikipedia article)
Can't a database be potentially breached and suddenly my account has all the "currency" copied I to it from yours?

Until Quantum Computing comes of age, this is theoretically much harder with DLT / blockchains.
MTN has launched AI-based chatbot for mobile money