skysight-inc/HackerNews huggingface dataset:
> Plant-based foods use fewer resources per calorie and do not require cruel treatment of animals.

They kind of have to at some point, otherwise you're using artificial nitrogen to top up the soil and that's not just bad for the soil but is also depleting a limited resource (The nitrogen comes from what IIRC is, a single mine).

I remember reading about some farmers that managed to buck the usual statistics by getting around half a thousand chickens to an acre of farmland -- the chickens acted as a natural form of pest-control for the farmland, and their shit and corpses (when they died) provided a natural source for the NPK needed to feed the soil.

The thing is, vegans forget that plants, etc. have all evolved with death as part of the equation. Animal death is required in some form, to supply the micro-organisms in the soil with the proper nutrients. Anyone who has studied farming and agriculture knows that the ideal isn't to eliminate animal death (something that is pretty much impossible unless you want to destabilize the ecosystem and starve your plants), but try to minimize it and ensure that the death is not wasted.

I think this mistake in understanding goes back to school, where children are taught that if you give plants soil, water and sunlight, they will grow. They could take that opportunity to talk about the NPK cycle, the billions of micro-organisms in the soil that need to be fed to provide the plants with nutrients, the fact that dead animals help feed the plants and the micro-organisms, etc. Not teaching children about this when children are capable of understanding it is a disservice given that for many people that is the only schooling that they will ever have on farming and agriculture.
Isn't it fascinating that the English language doesn't have a distinction between the social meaning of free and the economic, in that these meanings are meshed into the same word?
I mean this is obvious, right? Salads on fast-food menus have more fat and other "bad stuff" than burgers thanks to cheese, dressing etc. Your FF faux burger is still fried, cheesed, sauced etc. Next please.
The rural area around Paradise isn't very earthquake-prone. It's just pretty large and sprawling, which is what makes burying all those cables so expensive.
Isn’t being bald culturally more of a negative among White men?
Successfully developing functional fusion power is considerably more plausible than practical quantum computers in the near term. The problem with fusion research is that it is and has been massively, chronically underfunded.
Sounds similar to the argument about WordPress, third-party plugins, and the GPL from a while back.
> DNA not only contains the most basic information, but all the information.

This is simply false. I don't understand why you would make this claim. You mention counterexamples below (e.g. PTMs). As you know, DNA dictates whether a protein can be expressed or not, but not whether it is expressed in any particular cell, how much is expressed, or whether and how much is activated or otherwise modified over time. And, of course, it can't contain environmental factors, such as the gut microbiome from the OP.

> Isolating a single protein, looking at its expression, and assaying activity is not only the bane of every biochemists existence, it takes a significant amount of time and would have to be done for every single enzyme that we want to look at.

I worked for a few years in a lab doing quantitative protein expression, including certain PTMs, that can compare multiple states (e.g with and without a drug, or in different tissues) across a large section of the proteome. This was not particularly new 10 years ago, but it is a lot of work, and sensitivity, specificity, and practicality is still improving rapidly.

> Why would I want a snapshot of something when I need to predict drug-gene interaction before I give someone a drug?

Because there are cases (probably the majority) where drug-gene interaction is insufficient.

I'm certainly not trying to argue that there aren't significant examples where the gene existence is sufficient. It sounds like that will continue to be an essential part of diagnosis and treatment. It is not surprising that current state of the art stops at these straightforward gene-based analyses, but it is surprising that you think it will be sufficient going forward and don't think the nuance of real protein expression will be useful. There is so much room between measuring "gene-existence" and measuring "intelligence". Adding pharmacoproteomics to your list of "ways 21st century medicine will be awesome" is a pretty gentle request!
The new tab page has a list of bookmarks you can customize. It starts off with some "recommeded" sites in there, but you can just remove them once and they never come back. The only thing you can't remove from the new tab page is the Google search bar, which never really bothered me. Either way, it seems like you're implying that Opera will populate the new tab page with sites it chooses, but that's just not the case.
> Nutrition is a major reason that people are giving plant-based burger a try

Not really sure about that. Current meat "production" involves destroying the planet at an accelerated pace while treating animals in the most horrible way imaginable (and even beyond imagination).
Predicting Sales with LSTM
I liked reading this! I'm glad you found happiness doing this sort of work!

One thing I'd say is that it's awfully tough to do this sort of work as a contractor when there's a (direct) hourly cost for your time. It's tough when you're on salary working on an internal project... but doubly tough (not impossible) when you're a contractor! Theoretically, it would be in clients' best interests to improve efficiencies, but it's really hard to get a client to sign off on hundreds or many thousands of dollars of work for a future gain that's hard for them to grasp.

(Getting them to grasp it is part of our job, of course)

Then after the fact I say, "Remember when this used to take a week? Now it takes an hour". Once you do that a couple of times, management gets the point (usually)

This is great advice. It's all about those metrics and demonstrating the value of your work!
Why use total cholesterol instead of LDL?
Sure it has its uses for simple obfuscation but in that case my central point is relevant. It's only good for obfuscating ASCII letters.

Btw what's commonly known as Caesar cipher (aka shift cipher) is a generalisation of Caesar's original cypher (described as shifting each character 3 places). ROT13 is different from the "original" as it shifts by 13 characters over a 26 character alphabet. This makes the encode and decode steps the same.

You can play with different alphabets and shifts here: https://crypto.interactive-maths.com/caesar-shift-cipher.htm...
I think you're a big outlier, or at least you would be in the US. I have no idea what work culture is like in Australia, but it stands to reason it would be better than here.

US working hours are nuts, IMO.
Battle testing data integrity verification with ZFS and Btrfs
Do you literally do this?
Maybe if they'd called it freedom software?
None that they want to show you. I'm sure they still have the data and use it silently.
I mean... at least it has mouse gestures. Hard to knock it for being not feature-rich enough when it has a feature no other browser has by default (except Vivaldi, which has Opera lineage).
Very good, related, article in the New York Times:
https://www.nytimes.com/interactive/2019/06/07/opinion/sunda...
The venture capital investment model is mostly built to interface with C-corporations. Most businesses take another form of organizations. For example, limited partnerships have been a common way of organizing capital for film production and real estate development. The economics of the tech industries are attractive to the venture capital model, just as real-estate is attractive to long term investment by life insurance companies and pension funds.
Age discrimination against young people is temporary and is not causing any major (or even minor) social problems. One literally just has to wait a bit longer while being gainfully employed.

On the other hand, older people can't get jobs and their livelihood + potentially the livelihood of their families is at risk.
I don't have my OED to hand to check, I'd be surprised if it wasn't in there though. I had come across the word prior to my introduction to free software, I'd come across gratis also.
- Create multiple bots.

- If necessary (it isn’t clear to me whether the API allows you to choose your bot’s name) have those bots inform themselves of each other’s identity by gossiping on themselves, specifying a secret number.

- Only play against your own robots.

- Either make them all cooperate all the time, or designate one winner that betrays all the time.

- Play a lot of games.
I wouldn't have any issue justifying spending reasonable time making webpages as accessible as possible (even with image replacement text, blind people are going to miss some of the info in the image), but I miss exact guides as to what that means. At present I can throw in some Aria tags, but I don't know when that is needed (can webreaders figure out that <article> means an article?) and I don't know when that is enough.

I am also not in the US, so I can't tell my boss to spend disproportionate amount of dev time on something that doesn't make money.
And of course, management often loves that sort of dude. The burden of proof is usually on you to prove why your slower-in-the-short-term approach is better than that guy's approach, which will get working code into production two hours from now.
Can't Git No Satisfaction: Why We Need a New-Gen Source Control
I suppose it has a certain aesthetic but it's pretty far from what I consider a "beautiful" bicycle. This one is a lot closer:
https://www.instagram.com/p/BsVu9Idn8AO/

Also I am not sure someone like the author with an "aggressive" riding style can be trusted with the extra power from an ebike. People like that are aggravating enough with a standard track bike.

Not sure I want that kind of smarts in a bike either. App enabled, GPS tracking? How long until a "my left shoe is bricked" firmware update, or the company goes out of business and no one can unlock their bikes?
Kevin Bacon Shares the Tremors TV Pilot
If anyone wants to see the nuts and bolts of how this gets done, I've been enjoying Millennial Farmer's channel:

https://www.youtube.com/watch?v=GbpsfshTfr8
Check out the Daily Dozen. It does require a vitamin B12 supplement. If you take a B complex it will include niacin as well which will help with cholesterol.

https://youtube.com/watch?v=MqmSMunAtss

Also, lose weight. The body induces some beneficial activity while fasting.
Gratis as in without any associated cost and fri (free) as in without restrictions is the usage in Swedish as well.
So many business people I know have their own Yelp horror story. How is this company even still in business?
In fact, it is also a Spanish word, roughly pronounced "leebray" (in Italian and Latin it's different, though).

In fact, just learned now that it's supposed to be loaned from French, I had always assumed it to be from Spanish (I'm biased because I'm Spanish).
I'm a soon-to-be third year CS student. If I started to use the term "libre software" I'd be ridiculed to hell and back. I think you overestimate the receptiveness of developers.
Loop Optimizations in LLVM – Issues and Solutions
I was born in and still live in Glen Avon. Seeing this little town on HN is a surprise, to be sure.

Feeling a few earthquakes a day has been an interesting experience. It has been going on for days now, and quite a few people are on edge. I tend to think a lot of smaller earthquakes are better then one large one, and all of these earthquakes release potential energy that could have been released in a larger event.

I'm sure we'll be fine, but I hope those aren't famous last words!
Thank you for providing the context.
You can get much more out of Uni but IMO a degree certificate is, and should only be, a measure of ability to complete the stated academic requirements.
Probably because most data disagree with this comment. There's a ~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL.

The CTT is probably the best summary of these data: https://www.cttcollaboration.org/
A recruiter gave me a great piece of advice, to ask the question towards the end of the interview, "is there anything that would cause you to think I'm not quite qualified for the position," this way you can get such concerns out in front and be able to address them while it's still convenient and before they reject you for it.
I know where you are coming from. Because of $bad_life_decisions until I was 35 and purposefully choices since then, I am behind financially by any objective measure.

You could say my career trajectory is behind being in my 40s and still being an individual contributor, but I don’t see any scenario where I would have wanted to be a person manager. (Been there done that. Went screaming back to an IC role).

But, I do see a narrow path where I can retire at the standard retirement age and be okay with a paid off house, enough savings to be okay, and hopefully social security between me and my wife collecting half of mine instead of her own.
But non-proxied Bing results are still far worse than Google, so I chose StartPage. :)
You realize most of the atmosphere is Nitrogen, right? I would not call it a limited resource. Clovers and other cover crops also fix hydrogen.
Nurse the Rolling Stones Shirt
The author criticizes Trump heavily, but then starts to support traditional media under the guise of journalism. The overwhelming majority of major news networks in this country are for profit and bloated by corporate greed. Don't get it twisted, traditional media should not be trusted, neither should Trump. The enemy of your enemy is not always your friend, and the media is picking this battle carefully so as to rake in more clicks and profit.

I am getting disgusted by how the left is becoming more and more friendly to corporations and traditional media in the wake of Trump. A corporation can never be woke or virtuous. A corporate entity supporting lgbtq rights or diversity is the same as when Hitler supported animal rights or labour standards; Hitler is still evil, and so are corporations.
r/algotrading is another resource
The convoluted code definitely didn't help (message passing between several processes, 4000-line functions...)

Oh man, yeah. This kind of thing's hard enough in a single threaded monolith, much less when you've got multiple processes!

One time I was actually able to kill/retire a whole bunch of external processes and bring stuff back into the monolith. Yeah it made the monolith 1% bigger or whatever, but I think it was 100x better than throwing more services into the absolute gangbang of dependencies in which we were already drowning.

I'm glad you were able to move on and had other stuff to work on. Looking back, I probably should have just found another job rather than push through those legacy maintenance slogs. Lost sleep and hair for years, and it was sort of a career black hole.
Well, the study in the posted article examined Total Cholesterol (TC), not LDL, and the conflicting results you say were found in different studies were all about LDL, which suggests there really is some involvement of LDL in CVD. I wonder whether you might have misinterpreted these studies as conflicting when they are merely complementary in nature.

Additionally, I think you will not find many studies that claim that high HDL is bad for you, whereas you will find many that claim it's good (because it protects from CVD). I can't say I see much of "a mess" here- just ordinary, progressing scientific understanding of a complex system.

Are there really any studies that attribute atherosclerosis to bacteria, or some of the other conditions you describe? If so- are there many of those and are they good quality studies? I am very skeptical of your comment's suggestion that the immune system may be involved in atherosclerosis.
I am split: web pages can be enhanced with JS, but webpage mostly shouldn't need them (exception: some data visualization does benefit from being able to dynamically change values).

Web apps on the other hand, probably do need them. I use newsblur and definitely enjoy the shortcuts.
I just can't get over the fact that the parent poster derailed a thread about people not being able to get jobs - which is jeopardizing their retirement - only to complain about themselves being rejected for a CxO job in their youth.

Some really are blind to their privilege and arrogance.
Some people are indeed doers. I don't think the majority are though. Look at people on welfare, that's not how they behave.

I think you're confusing what you would like to happen with what is likely to happen.
Wouldn't that require the camera to be located nearer to the middle of the screen, where the on-screen eyes of the other party would be? I wouldn't mind a slightly perceptible camera dot at the top of the screen, but if it was in the middle it might appear pretty conspicuous.
I think if it did mean that, Linux would be abandoned by most major companies overnight, as you could not develop non-GPL binaries for it; I do however believe Blender is in the wrong here.
See also https://news.ycombinator.com/item?id=20137955
It's law in the EU for sure:

https://ec.europa.eu/food/plant/plant_propagation_material/p...

I'm not sure if the USDA has similar rules.
There's more to "healthy" than calories and cholesterol. What a trash article.
I'm not sure when AWS became the standard, but the programming communities have lots of young kids learning their first backends on AWS.

Im not sure this is a good thing, having a generation of developers dependent on a single companies tools seems like the future will be painful.
I never understood the benefits of the cloud for 99% of the projects.

I just moved https://vlang.io from Google Cloud (my free credit expired) to an Amazon Lightsail VPS (any VPS will do), and my spending went from ~$70 to $3.5/month.

And the performance actually improved a bit.
You don't know what you're talking about if you think those are equivalent. And well their public cloud is pretty much dead so good innovation!
ABP is compatible with the new API and will not be affected.

See: https://developer.chrome.com/extensions/declarativeNetReques...

This is API that ABP can use. But with the new API the rules list will be limited to 30 000 rules vs. for example 42 000 EasyList is using, and an update to the rules will require a full update of the plugin.

See also comments from gorhill: https://github.com/uBlockOrigin/uBlock-issues/issues/338#iss...
When I was in HK a few years ago, there was a lot of annoyance amongst the general public that GovHK was starting to get dominated by pro-China individuals. So I get the impression this bill is their doing.
Then those investors are stupid. Hope is not a strategy. But more likely is this take is wrong. Also sounds to me like GP maybe missed another consideration: architecting your application in such a manner that scaling is straightforward (not easy, straightforward, there is a difference).

Using AWS as an example, at one of the businesses I worked at, we used Kinesis as an event bus. One shard handles 2MB/sec of output. This worked pretty well for thousands of messages a second, we even got up to the 100's of thousands by compressing the payload of the event message. After that, you can employ any number of strategies that work easily, such as shading and adding additional streams, and use a lambda to pipe the output of one stream to another. It scaled up to millions of messages by essentially pushing buttons in the AWS Console.

Take a look at your architecture. More than likely, outside of a FB/Google/Netflix traffic scenario there is probably an easier and more straightforward architecture you can use that scales to your realistic use cases. Worry about the billions when you get there, which you yourself probably wont at that point because you would have exited, or moved into a higher role most likely by now.
(Micro)services and separate codebases are orthogonal.
You can have multiple separate components (libraries) implemented in different codebases and linked as a single executable (which is actually really common).

You can have (micro)services deployed from as single huge codebase - just take a look at all so-called monorepos.
> Do you have any idea about agricultural breeding? [..] Which is why companies have any say in breeding at all.

Do you have any idea about industry lobbying to restrict the use of traditional seeds [1]? Companies use every trick they can to increase profits and control - a superior product is merely one of them. There is also lobbying, marketing, anti-competitive contracts... It beggars belief to be so naive as to think otherwise.

[1] http://www.arc2020.eu/european-seed-legislation-a-turning-po...
Offtopic, but I've been wondering where people are getting all this free beer from? Where I come from beer is quite expensive.
Glad it helps. :)
Electric bikes with a removable battery are standard-issue “MamaChari” in Japan. Every city mom has one that carries two kids and/or groceries. Every grandma/grandpa has one (without the kids seats), too, to tackle the long hills!

Ebikes in Japan cost about $1,200 in USD equivalent, more or less.

https://www.japantimes.co.jp/life/2017/11/18/lifestyle/going...

I also notice that Chinese-style ebikes have taken root in a big way in NYC’s delivery business. Those cheap Chinese ebikes (and strange little service garages for them) are everywhere now!
It doesn't look like they directly test for this kind of thing, but they do address it:

Reverse causality has been suggested as an explanation of higher mortality associated with low cholesterol levels. However, a long term follow-up study in a Japanese-American population showed that individuals with low cholesterol levels maintained over a 20-year period had the worst all-cause mortality, and concluded that reverse causality was unlikely to account for the higher mortality associated with low cholesterol entirely14.

My reading of "reverse causality" here is that people with high TC have more cardiovascular disease and take more statins that lower their cholesterol. I haven't read the referenced study.
I think most discussions about the GPL have this feature.
Doesn't matter. Point is: while we need airplanes, we need to power them. While we can't power them using "green" sources of power, we should use liquid fuels. And while we need them, this idea (topic-starter) sounds reasonable.
Yeah. I'll happily pay £15-£20 for access to all newspapers. I'm not going to pay any one newspaper for a subscription, because I don't read that many articles from any individual paper.
The is good evidence to suggest that human ancestors started to use fire to cook meat and/or starchy vegetables more than million of years ago. It is enough for evolutionary adaptation.

There are even suggestions that it was cooking by opening untapped sources of calories that allowed for a bigger brain to evolve.
The Business of Health Care Depends on Exploiting Doctors and Nurses
How often do you use the term "free software" in the FSF sense?
> it means they accept that chrome is largely used by power users who can install these

You're making a very big assumption here. Last I checked people who blocked ads counted in the hundreds of millions and the number was growing rapidly.

Some old stats I found with a quick search:

https://pagefair.com/blog/2017/adblockreport/

> 615 million devices now use adblock

11% of the global internet population is blocking ads on the web

Adblock usage grew 30% globally in 2016

Mobile adblock usage grew by 108 million to reach 380 million devices

Desktop adblock usage grew by 34 million to reach 236 million devices
To me free software means, it is free to get and free to modify.

Why so complicated?