skysight-inc/HackerNews huggingface dataset:
Can you provide sources that suggest I'm wrong? Obviously there are difference of opinion on this (the supreme court decided these were not composition of matter patents), but I think it would be helpful for people reading to at least understand both sides.

These two articles discuss some of the thoughts about why the BRCA patents were considered valid by a number of legal experts:

https://www.nytimes.com/roomfordebate/2013/06/06/can-the-hum...

> But Myriad’s patents don’t cover genes in their naturally occurring, unisolated form, just as the aspirin patent did not cover chewable bark. Rather, the BRCA1 and BRCA2 patents claim the genes as isolated, purified and used in a scientific or medical context.

> Thus, Myriad’s patents cover the same “composition of matter” that these patents have always covered, and which built the modern pharmaceutical industry in the early 20th century.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979127/

It's at least not as simple as saying that these patents are just patenting the genetic sequence and anyone who even looks at them is violating patent law and that somehow others own the genes in our body.

You said:

> They enforced it against anyone else who wanted to test for mutations in the gene.

Anyone could be tested for mutations in the gene (in fact, 23andMe tested for those specific SNPs and you could see it in your raw data). What Myriad patented and enforced was using this in a specific medical context, as I understand it specifically a medical diagnostic test. Here is the BRCA1 patent: https://www.google.com/patents/US5747282

This is the abstract:

> The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.

Here is the insulin patent: https://patents.google.com/patent/US1469994

And here is the adrenaline patent: https://patents.google.com/patent/US730176

These are both things naturally occurring in the body.
This website is downright unreadable on mobile it goes completely white every five seconds or so probably trying to load some JS.
The conclusion makes it clear that this work has no aggressive intent:

Unfortunately, our work has identified numerous problems in the FSE study that invalidated its key result. Our intent is not to blame, performing statistical analysis of programming languages
based on large-scale code repositories is hard.

[...]

Acknowledgments. We thank Baishakhi Ray and Vladimir Filkov for sharing the data and code of their FSE paper. Had they not preserved the original files and part of their code, reproduction
would have been more challenging
HaveIBeenPwned provides the same notification service.

So why is Mozilla running an email harvesting campaign?
Pixels Camp CTF Challenge Qualifiers Write-Up
The article sort of reads as a list of individual incidents but I'm not sure it's able to present itself as a particularly alarming trend.

Yes, the Mona Lisa is the most popular painting in the world. Maybe the Louvre needs to expand or build a new space for it that can accommodate more people. Maybe ticket sales should be more limited and sell out after a certain point, with a set number of visitors allowed per day/hour/etc. It sounds like mismanagement (hence the workers walkout) than the tourists being at fault.

Yes, people are dying taking stupid selfies, but not really all that many of them, either.

Yes, some landmarks are being damaged, but also, governments completely have the power to enforce their laws and limit admission, and hand out tickets for littering and vandalism.
> Compared to that, I am pretty sure most i9-9900k setups are just for kids. ;)

Your machine is slower than a macbook air for most of my workloads about half the speed of my desktop so I wouldn't be so confident.
Yep - were going for forceps instead of ventouse.
Everyone and their dog has written a static site generator - and that is good thing.

Blogs are a personal creation and there is something very satisfying about publishing your own text using your own tools.

Things I particularly like about this project:

* No dependencies

* the generated pages are clean

* good documentation and usability

Since it is tradition at this point, here is my static site generator: https://github.com/andrewstephens75/gensite

And an example page: https://sheep.horse/2017/10/how_you_are_reading_this_page.ht...
The fact this is going to spread worldwide is inevitable. I honestly think we need to prevent people from this area of the world from coming to the US until they get this under control, this is simply unacceptable from a global standpoint.
Thanks for writing this.

I'd love to hear your input on a possible application for this. I'm not sure if you're aware, but Counting Bloom Filters are useful as space efficient counters in LFU cache admission/eviction [1].

I'm wondering if bloom clocks would be a good data structure for a space efficient LRU admission/eviction. Full LRU uses a linked list and sampled LRU just uses random sampling, but my intuition is that bloom clocks might perform similarly or better than sampled LRU...

The difficult part will be dealing with concurrency. I suppose it'd be easy to treat threads as "nodes", but not all languages have the luxury of thread-local storage (Go), so I'll cross that bridge when I get there.

Anyways, I'm going to test it out later - thought you might be interested in my thoughts on a possible use.

[1]: https://arxiv.org/abs/1512.00727
Their mechanical pencils are fantastic too. They also make amazing kitchen knives.
Getting started with a SaaS business as an indie maker
Taskwarrior, where have you been all my life?
https://blog.djy.io/taskwarrior-where-have-you-been-all-my-l...
https://news.ycombinator.com/item?id=17029560
Elastic is like this, except 1500 folks instead of 80.

We are in over 50 countries, we are 1,500 folks, and we are all distributed, people don't really use offices (esp. not those of us in R&D roles) and almost everyone works from their homes.

You get a generous stipend if you want to rent an office like WeWork, etc.

We generally gather twice a year in person, but we're not bound by offices so we can gather anywhere there's a large enough hotel or two.

I've been with Elastic for 3+ years and after doing remote consulting for ~7 years I can say this company is one of the best, if not the best, at getting distributed work right
Starting with state management in the first post is a different approach I wouldn't normally expect.

That being said I don't know what it is but I prefer writing games in C. I experiment with higher level languages and use them for rapid prototyping. However, and maybe its simply nostalgia, I always come back to C.

And it's not even my favorite language by a long shot. For practically everything else, save for systems programming, I prefer languages like Common Lisp and (more recently) Haskell. Imperative programs are notoriously difficult to comprehend and maintain but there is something about game programming specifically that C leverages which makes it a good fit for game engine development; the mix of pointers and machine-sized types perhaps? I'm not sure. But it works really well.
Autonomous Reinforcement Learning of Multiple Interrelated Tasks
Good question. My feeling is that distance creates emotional separation and vice versa. Maybe because remote communication is abstract and misunderstood quickly.

BTW: The best I’ve read about this so far is: “The Culture Code”
That depends on where you put it and how much uptime the machine sees. My cold storage NAS draws 70W idle, but its up time is at most a few hours per week - and I essentially got it for free. Since the 12 disk file server case sits in the basement it doesn't bother anyone with the turbines running.

I thought about going dual Xeon for my desktop, but found that I don't often need that much power (at home) to warrant excessive power draw you mention.
The most recent round of lectures for this course are excellent. You can find them here: https://www.youtube.com/playlist?list=PLDcUM9US4XdNM4Edgs7we...

I'm happy something talking about Statistical Rethinking has finally made it to the front page. I've tried and bounced a few times to raise awareness of this awesome course.
Minor detail: the entire i7-4770xx line of products are 4-core, 8-threads CPUs[0]

[0] https://ark.intel.com/content/www/us/en/ark/search.html?_cha...
As the article states: "while many sites are inarguably overcrowded, very few cities and towns are"

People aren't really going off the path, there is plenty of opportunity to get them to do that and disperse the crowds

I travel a lot and am mostly exempt from these crowds because I'm not rushing on a 5-day trip around a 3-day weekend to jam pack tourist destinations. I'm also not going to tourist destinations probably because I've already been there - in off-season no less - or have other things bringing me to an area.

Just disperse.
Something that I worry about is that it seems like almost every enjoyable/empowering thing is being considered harmful to the environment/society or is becoming difficult to afford:

Driving a car, eating meat, travel, owning a home, living in a popular location (e.g New York), owning a gun, etc.

Combine that with an increasing number of people who feel socially isolated and it seems like a recipe for unrest.
Here a documentary about the case of Mallorca (subtitles in various languages, 65 minutes long):

http://totinclos.cat/documental/
One of the simplest but more important conclusions that affects me all the time... it’s easy to search for things, but hard to know whether you’ve got all the answers you want and hard to know if all the answers you got are answers you want.

6.3 Grep considered harmful

Simple analysis techniques may be too blunt to provide useful answers. This problem was compounded by the fact that the search for keywords did not look for words and instead captured substrings wholly unrelated to software defects. When the accuracy of classification is as low as 36%, it becomes difficult to argue that results with small effect sizes are meaningful as they may be indistinguishable from noise. If such classification techniques are to be employed, then a careful post hoc validation by hand should be conducted by domain experts.
I’m not sure if they teach the times tables anymore but the way they teach math has certainly changed a lot since I was in middle school. I volunteer as an after-school tutor and I have a really hard time when kids bring me the “common core” multiplication and long division. The kids do actually seem to learn math better with their criss crossy drawings that they do to “solve” the problems but I can’t wrap my brain around it.
> One of the problems that smart, educated, intern-level immigrants have is they are getting caught in the crossfire of millions of uneducated day-laborers streaming over the border.

Unless you take the position that immigration policies should be based on primacy of residence, in which case, bringing in specialists over non-specialists while at the same time not promoting specialization for natives is detrimental to the current residents. If we spent as much money on visas training the amorphous 'backwards middle america', we probably wouldn't need so many specialists.. and this 'need' is itself debatable..

i prefer working class immigrants. perhaps it is because as middle class i don't see them as a threat, but they seem much more humble than Dr. So And So who demands XYZPQ because he is a Global Elite YakketySchmakety.
I'm in that list as well, don't remember ever signing up for it.
This will work if you are located in big western city. He bought his Z420 for 50$, and when I check ebay right now they are going for 150-300$ + 100-200$ shipping. And that with E5-1603 CPU, not the E5-2667 or similar. Lets say I have 5 year old AMD FX-8350 due to upgrade this year. That Xeon is actually slower, looking at some basic benchmarks (of course it may be faster in some, but I don't have time for detailed investigation). So ~300$ total for a sidegrade? And that not including hassle with shipping, maybe dealing with scammer seller from ebay, then import tax 30% (and who knows how base price will be calculated at customs). Etc. etc. Not worth it.

I'm not saying that upgrading for cheap is bad of course, but getting stuff like described in the article is borderline lottery win in most of the countries. You can't depend on it or plan in advance.
But analytics in an OS is spyware, doesn't matter who does it.
Bialgebraic Semantics for String Diagrams
It seems like the added cost/time of communications for a remote group is less than the cumulative commute times for everyone, but it has to be a priority and part of the deal.
The Xeon workstations I have and can easily access, are all 32bit

What good will one let alone several 32bit machines will do for me now a days.

I can use Ubuntu, or chain them, but how would you do anything with virtualization and advanced computing.?
I work for a company that has a global presence. Teams are often distributed across a couple locations. We also have some remote workers. We have people in one office who's entire team is in another office. We have people who are the sole person on their team in a given location. There really is no practical difference between working remote or working in a different office at that point.

Yes, face to face interaction has a lot of benefits that are noted throughout these comments but once you've incurred the overhead that comes from having more than a couple locations letting people work remote doesn't have any negative impact.

I can see why some 20-person trendy startup that hasn't had time to figure out how to effectively coordinate across multiple locations doesn't want to hire remote. They don't want to incur that overhead yet. For bigger established companies there's no good reason not to hire remote or at least allow the flexibility to work remote as needed.
New release of Microsoft Recommenders: new algorithms, notebooks and utilities
Well with the API it’s pretty easy to test your password. You just have to hash it, send the 5 first characters and it returns the list of the hashes starting with those 5 characters.

You then just check.
>Women are enculturated to be uncomfortable most of the time. And to ignore their discomfort.

>The real problem isn't that we — as a culture — don't sufficiently consider men's biological reality. The problem is rather that theirs is literally the only biological reality we ever bother to consider.

>It boggles the mind that Sullivan thinks we don't sufficiently consider men's biological reality when our entire society has agreed to organize itself around the pursuit of the straight male orgasm

The article addresses a couple real concerns. But the quoted bits make me think that the author has constructed a viewpoint about society that is intentionally unrealistic and hystrionic. When you do that, you get to beat your war drums, but you lose credit to folks that aren't on the same rhythm.
> Governments are also rolling out regulations, such as bans on tour buses in Rome and gating-and-ticketing in Barcelona.

The ban on tour buses might actually end up being counter-productive, if that one bus is replaced with many more smaller vehicles that in aggregate take up a lot more space on the roads.

A better solution would be a universal congestion fee that all vehicles entering the most congested zone pay (and yes, the fee for large vehicles like buses would be higher).
The way people move about the world unchecked is irresponsible. We are more careful about cattle than humans.

That said, any mechanism for checking travel will undoubtedly turn corrupt. So it comes with that cost.
Working in a bigger place you may not have the same physical access. The smaller the place the more opportunity for cross department chatter remote or in person.
It makes sense if you need much Ram.
DDR3 RDIMMs used from ebay are really Cheap.

And the price difference for the whole system is huge if you buy used.
I payed for my System with a Xeon 2680 V2 (10C20T) 128GB Ram just a little bit more then the asking price for the 9900k alone.
But I bought it almost 2 years ago so the comparable Mainstream CPU at that time was the 4C8T 7700k.

As a student with a limited budget performance per € matters more then performance per watt.
Missing discussion of globbing which is also extra work on Windows.
Okay, by the standard you laid out: the paper that is the subject of this paper failed.

But similarly, if you say, "Here are our statistical models, they're in a notation for a private, custom MCMC system you can't use" that's probably failing the standard even if the work is good.
How is owning a gun bad for the environment? It's somewhat expensive but not that much compared to other stuff.
A large chunk of their marketing nowadays is around privacy and it looks like it's more and more in their priorities, and Apple is a company that has historically loved by suckling at their customers sweet wallety nectar.

So yeah even if they're driven by money, their best interest is aligned with their customers'- living up to the promise that your data is yours with them.

The other thing is that there seems to be a better chance at being private with a company that does not start its promise by telling they want to know everything about you and "index the world"
Indeed, and in addition to selection bias towards better programmers, there is another selection bias implicit in this.

A shop that makes the decision to write their stack in Haskell do it with an intention to focus on correctness. I reckon that such companies would consequently invest in other practices like more tests, higher code coverage and more intensive code reviews resulting in code with fewer errors.

This is in stark contrast to a startup that may have hacked together a POC in Python, and once it worked, with a little bit more spit and polish put it into production.
Apparently MyFitnessPal had their data breached, and my email address/password was in it.

Checking my emails, I can't see anything from them about this. Loads of the usual marketing crap, but nothing about a breach.

Not cool!
> 2. Fully remote companies are generally of 3 kinds: a. companies you've heard of and they're serious but since they're looking to hire from a global pool they are extremely picky

There are many serious remote companies that will only hire in their country (or worse).

> 4. You essentially are a contractor. Few if any or remote companies hire you as an employee (but you are paid as an employee).

This doesn't make sense. I am paid as an employee, I am an employee.

I agree with most of the rest though.
What Content Dominates on YouTube?
Yes, and that's why the logic is wrong: the problem is not too many people want to do x. Wanting is legitimate.

The problem is thay there are too many people, period. And the more fair we make the system, the more they will get to do what they should expect from life, so it's going to get worse.

I often read on HN that this is not a zero sum game. Whatever, we are not leaving this earth anytime soon, and we are not producing innovation fast enough to care for everbody.

Soon, the state of mumbai will be mirrored in other places. Beggers like in LA as well. Venise and phucket are already terrible to live in.

Population is the main problem. It is a problem for food, education, hell, democraty. Eternal growth is not sustainable.
Sony isn't really Japanese any more, it's a multinational corporation with operations in many places, including the US. This is like trying to claim that Ford cars are all-American (they aren't, they're largely made in Mexico, and they have a large European subsidiary too).
I fear this is just a "reaction bait" piece.
Disincentivizing air travel could have a big impact on climate change as well. I don't understand why those who want to do something about climate change still fly around the country/world like its nothing. A single plane ride from NYC to LA emits about 20% of the greenhouse gases your vehicle does each YEAR. 5 trips in one year and you've essentially been running a second car for that year. [0]

If you care about climate change and you still fly I can't take you seriously.

[0]: https://www.nytimes.com/2017/07/27/climate/airplane-pollutio...
I was about to counter that self hosted is an option, but that doesn't technically qualify as an "email service".

I'll note that the privacy centric services are only good as long as they're still maintained by a founder... you trust. If things go sideways, they can always be "acquired".
> I honestly think we need to prevent people from this area of the world from coming to the US...
...this is simply unacceptable from a global standpoint.

I’m guessing you’re in the US? What about the rest of us?
The parent wasn't saying China would introduce the motivation, they said fear of China would erode the taboos that presently stop us from giving in to the motivation.
Add the fact that this breakout faces different challenges than previous ones (increased frequency of aid worker casualties due to civil unrest).
Old xeons are hot, and power hungry.

My monthly electric bill decreased by nearly $10 after replacing my 2010 MacPro with a 2018 MacMini.
I suspect that people are rushing to do a 5 day vacation or 3 day weekend because that is there only option.
Ebola is much less contagious than people think

https://www.businessinsider.com/ebola-discoverer-would-sit-n...
Sadly, we have killed humbleness some decades ago.

There are often cognitive advantages associated with shy people. But of course this article advertises treatment.

edit: With BCT, the acupuncture of psychology.
I'm not American mate.

Don't be so presumptuous, it's arrogant.

And you are cherry-picking stats by stating only sales on Steam. Steam is not the only digital delivery platform on PC. There are many.

From 2014 worldwide:

https://www.kitguru.net/gaming/matthew-wilson/92-percent-of-...

92% of game sales worldwide were digital.

From 2019 in the UK:

https://www.eurogamer.net/articles/2019-01-03-uk-video-game-...

80% digital sales for games in the UK alone.

And it's not just the UK and US.

https://business.financialpost.com/technology/gaming/digital...

The number of physical sales is declining everywhere, some quicker than others.