skysight-inc/HackerNews huggingface dataset:
Those people all have guardians, whether assigned by default by virtue of family relationships, or assigned one by a court. Their rights are defended by their guardians. An abusive guardian can deprive their wards of rights if they so choose, and this is why we have procedures established and criminal codes specific to faithless guardians--child abuse, elder abuse, even cruelty to animals.

The ward can't be expected to prevail over their own guardian, so other people with moral agency have to be prepared to remove and replace a bad guardian.

Without guardianship and advocacy by others, those people could be abused at will. A bad guardian could prevent abuse from everyone except themselves, assuming a monopoly over the abuse of their wards.

But you can't exactly replace a mother in the middle of a pregnancy, can you? Certainly not without doing harm to her. Thus, I am unwilling to advocate for a fetus to the detriment of its mother. It's pointless. You can't help that fetus until after it's a baby, and it won't ever become a baby if that's not something the mother is willing to do.

When the state forces a woman to carry an unwanted pregnancy to term by prohibitions and threats of force, that is itself an abusive relationship with a large imbalance in power.

A fetus has no inherent value. It is worth what its mother says it is worth, anywhere from zero to one whole person. That's why a battery that causes a miscarriage can be considered a murder, but an abortion is not. Once that baby is born, it will likely be considered a whole person from then onward, because there's probably always going to be a potential guardian around that's willing to bid that high. But when you find a class of person like homeless folk unable to manage their own affairs due to mental illness, that's when you see that they have fewer rights in fact, because there's a dearth of people willing to act as their guardians. They have no inherent value, and no value borrowed from others, so predators can beat them up and steal their stuff, and nothing happens to fix it.

Giving value to those who have no inherent value--so they may live in our society as equals before the law--is virtuous, but in order for that to happen, someone with inherent value has to lend some of theirs. Not everyone is willing to give themselves for the sake of someone who will likely never be able to return that favor. Some people don't have enough excess to spare anything. Some people always need to turn a profit.

If you oppose abortion, and don't already have some adopted children or an unrelated adult dependent, you might just be fooling yourself about how virtuous you really are. When you bid someone else's value up to a whole person, you must be prepared to pay that bid if you win, by becoming their guardian and defending them against anyone who would treat them as less than a whole person.
But then how do you wash the area under the watch without taking it off?
Systems of quantum computers can verify NEEXP problems
Recursion Pharmaceuticals | Salt Lake City, Utah | Onsite, Full-Time | http://www.recursionpharma.com/careers

We have raised over $80M to apply machine learning to one of the most unique datasets in existence - over 12 billion images of cells under a huge number of biological and chemical perturbations, generated in our own labs - in order to find treatments for hundreds of diseases. Our long term mission is to decode biology to radically improve lives - we want to understand biology so well that we can fix most things that go wrong in our bodies. Among other awesome folks, Yoshua Bengio is one of our advisors, and helps our ML team come up with novel ways of tackling these problems.

We’re looking for:

* Data Scientists: Looking for experienced Data Scientists both for our Innovation and Assay Development as well as Image Analysis and Quality teams. You’ll work with our data, biology, high throughput screening (HTS), and engineering teams to identify and answer questions in high-dimensional data.

* Sr Full-Stack Engineer: Looking for a strong Full-Stack Engineer. Great opportunity for experienced engineers interested in coding for a meaningful purpose (and a massive human impact) and building distributed systems, web apps and tools for biologists.

* ML Researcher: Looking for a highly experienced senior/principal-level Machine Learning Researcher who wants a challenging problem, lots of rich data, and knowledge that their breakthroughs will seriously help people. No bio background needed.

* ML Engineer: Looking for experienced Machine Learning Engineer who values experimentation and the rigorous use of the scientific method, high collaboration across multiple functions, and intense curiosity driving them to keep our systems cutting edge.

* Biologist, Computational Chemists, Automation Scientists, and Drug Discovery experts.
http://www.recursionpharma.com/careers for more details and to apply.

Logistics: Salt Lake City, Utah. Hiking/running/biking is literally out our back door, and it's half an hour to 6 ski resorts. Great pay, health insurance, 401k, relocation assistance (onsite is required), equity, fully-paid gym membership, complementary chef-prepared meals everyday, two one-week paid company closures in addition to flexible, generous vacation, 70ft onsite rock climbing wall, commuter benefits, a top-caliber team, and help make a massively positive impact. Happy to sponsor/extend visas, but you need to already be authorized to work in the US--we can’t handle the lottery at this stage.

Tech:

Data Science: pydata stack (pandas, numpy, scikit-learn, matplotlib, bokeh, tensorflow w/keras, etc), a cluster of GPUs for all your research ideas

Software Engineering: python, clojure[script], javascript, go, react.js, kafka, kubernetes (GKE), GCE, AWS

Our team of 148 so far: http://www.recursionpharma.com/team
Streak | YC S11 | Senior Frontend Engineers | Vancouver, BC | Full Time | Onsite

* Problem: Make Gmail powerful for all businesses
* Product: We build a sales/hiring/fundraising/dealflow tool all inside Gmail. We believe these workflows belong entirely in your inbox because thats where people spend their entire day.
* Traction: Product market fit, hundreds of thousands of users, tens of thousands of paying users
* Stack: Java, Kotlin, Golang, React, all the modern JS tooling - built on GCP, largest user of Google Cloud Spanner
* You: Deep & foundational knowledge of frontend web engineering. From how browsers work to modern frameworks and everything in between.

We're growing our Vancouver eng team significantly and offer competitive compensation with amazing benefits.
Interested? Visit and apply at https://www.streak.com/careers/product-engineer-vancouver
I won't presume to answer for the OP, but my (remote conference attendance) pet peeves include: I have printed out important information (but forgotten to email it); let me use the whiteboard that is mounted on the same wall as the camera to illustrate a concept; I will speak exactly loud enough so that only people in the room can here me; I will use the free tier of some conferencing service, and start the call fifteen minutes early so that the connection drops halfway through the meeting.
Root Insurance Co| Columbus, OH / Chicago, IL | Full-time | Onsite / remote (US only)| $80k-$170k

https://root.engineering/

Root is an auto insurance carrier, like GEICO and Progressive. We use data science to identify and insure good drivers, reducing insurance premiums for good drivers significantly as a result.

We're a startup — we're 600+ people who have been working on this since March 2015. We've built an iOS and Android app that gathers data on how well people drive. We use that to set insurance prices. To build the best possible product and user experience, we went through the arduous process of starting an insurance carrier from scratch.

We're focused on becoming a national insurance carrier and are now live in 24 states.

We've raised $180M in Venture Capital since 2015 and we're scaling rapidly. To do that, we're looking to bring on more exceptionally talented engineers. Whether you're just getting started out in software development or someone who is looking to lend your experience in leadership to a rapidly scaling engineering organization, we plan on doubling our engineering team in the next year alone.

Our tech stack involves Ruby / Rails and Javascript / React Native. However, we're not only looking for people with experience in our stack but rather we're looking for experienced technologists with sound engineering fundamentals using any technology.

We're actively hiring in Columbus, OH and are also building an Engineering Team in Chicago, IL that will be working very closely with our telematics data. This team will play a major part in where we're headed, and we're searching for experienced Engineers who are looking to have a significant impact by building and leading a team from scratch specifically in Chicago.

Email us at enghiring@joinroot.com to apply and either Tim or Chris will respond to you promptly.
A good illustration of why it might not be such a great idea to fly no flag and claim no nation: anybody who floats up with a gun bigger than yours can go right ahead and subject you to whatever "law" they feel like.
SEEKING WORK | Europe/UK/US/Australia | REMOTE YES

-

We are a team of two who do heavy full stack lifting with Clojure/ClojureScript as a primary weapon of choice.

Experience so far in financial, maritime, media, social, gamedev, CRM, online marketplaces, cryptocurrency/blockchain exchanges.

Classic vertical apps, distributed messaging and streaming systems, microservices.
A lot of Datomic under the belt.
iOS/Android upon request.

-

Website: https://immute.co

Email: stan@immute.co

Phone: +442080896901

Keywords: Functional, Clojure, ClojureScript, Datomic, Java, Python, RabbitMQ, AWS, NixOS, Wolfram, Mathematica, backend, frontend.
I've built https://findwork.dev/?source=hackernews to index the postings here so that they're searchable. I also enrich the jobs with data from Glassdoor (reviews) and Crunchbase (funding). I use it for my own job hunt, but it might be useful for other too...
I don't have too much preference on where I want to go, I do know where I don't want to go - I don't want to go to countries where my visa is tied to an employer, I also don't want to go to overly religious places (like UAE etc). I prefer English speaking countries, but that is not a deal breaker.
What? Of course there is low cost train travel. It is garbage, but it exists.

https://www.flixtrain.com/

However, if you want to go Hamburg-Munich on an ICE (better than flying imo IF (!) everything works) and you do not have purchased a "BahnCard" and you do not book far in advance then it is very expensive.

2nd class ICE ride on that track in 2 weeks is 153€, flex, one way. For that money you get a return flight.

If you can be 100% sure to make it to one exact train you can go for ca. 50€. [1] Risk of failing to catch that train is pretty high though.

[1] https://reiseauskunft.bahn.de/bin/query.exe/dn?revia=yes&exi...
Hi Aaron! I got to the assemblyscript slack signin page here -- https://assemblyscript.slack.com/ -- but there's no obvious way to get an invitation. Where should I click or send a request to? Or if you could please send one to don@donhopkins.com, I'd appreciate that. Thank you!
Location: Europe/UK/US/Australia

Remote: Yes

Willing to relocate: Yes

Technologies: Functional, Clojure, ClojureScript, Datomic, Java, Python, AWS, NixOS, Wolfram, Mathematica, backend, frontend, fullstack.

Résumé/CV: https://immute.co

Email: stan@immute.co

-

Experience 18 years so far in financial, maritime, media, social, gamedev, CRM, online marketplaces, cryptocurrency/blockchain exchanges.

Classic vertical apps, distributed messaging and streaming systems, microservices.

Originally from Ukraine, I am now roaming mostly in Europe and doing heavy full stack lifting mostly as a contractor via
own UK company. Currently open to part, full time projects and serious gigs.
Taiwan's digital minister on combatting disinformation without censorship
That said, life might be way less stressful for you. It's just a different world, quite impossible to determine how you would like it before you try it. Weather is a bitch though, think Seattle or something like that. Work life balance is amazing here and throughout most Europe.
ProcedureFlow | Full Stack Developer | Saint John, NB, Canada | ONSITE | REMOTE in Eastern Canada | Full-Time | https://procedureflow.com

ProcedureFlow allows you to turn your company's procedures and expert information into small, hyperlinked flowcharts that are easy to follow and maintain.

ProcedureFlow has a lot of great paying customers that consider us vital to their business. We're growing our development team as we start to scale. We've more than doubled our revenue and staff in the last year and are close to Series A funding.

Our technology stack includes: ASP.NET MVC, C#, Postgres, Redis, Node, Terraform, and AWS.

We're looking for someone who has:

• A demonstrated mastery of building cloud-based web apps in ASP.NET MVC/C#.
• Experience as a generalist working on both the frontend, backend, and anything it
takes to solve problems and delight users.
• Pride in working on projects to successful completion involving a wide variety of
technologies and systems.
• The ability to stitch together many different services and processes together even
if they have not worked with them before.
• Empathy with their users and are stewards of crafting great experiences.
• Skills for upholding best practices in engineering, security, and design.

Interested? Send us your resume, GitHub profile, or anything you'd like to showcase: https://jobs.procedureflow.com/o/full-stack-developer

I'm a co-founder and the VP of Product Development. Happy to answer any questions!
Location: Tel Aviv, Israel

Remote: Preferred

Willing to relocate: I am moving to the east coast in one year

Technologies: Python3, NodeJs, Docker/k8s/OpenShift, linux-user

Résumé/CV: https://drive.google.com/file/d/0B270A8MYgd0TOW1kbWU1bnVHMnJ...

Email: bzupnick+whoshiringjune@gmail.com
Tapad | Full-Time, Onsite: NYC or Oslo | Open Compensation

Tapad is known for inventing and introducing the Tapad Device Graph™ to the industry. At the heart of it, we dig data.

Tapad's Open Source tech stack (below) handle:

___________________________________________

Distributed Applications... Scala, Python

Distributed Computing... Google Cloud, BigQuery, DataProc, DataFlow,

Open Source Technologies… Kafka, Zookeeper, Spark

___________________________________________

Here are our open roles in Engineering:

Senior Data Scientist (NYC): https://grnh.se/3856493a1

Solutions Engineer (NYC): https://grnh.se/635dfbca1

Senior Software Engineer (NYC): https://grnh.se/fd28fb141

Senior Software Engineer (Oslo): https://grnh.se/619bbb561

-----
It's true, but Microsoft has also done a pretty good job of failing to lock people into their development platform, and seems to have largely given up on it. Does anybody use COM or WCF anymore, except maybe to maintain or talk to legacy systems?

It leaves us in a situation where it's hard to get any more locked into Microsoft than it is to get locked into Haskell: Sure, you can build up a whole lot of dependencies on libraries that don't have great equivalents on other platforms, and any wholesale migration is going to involve rewriting a mountain of code. But interoperability relies on the same open and de facto standards that everyone else is using these days, so your migration paths are exactly the same as they'd be anywhere else.
It is beyond critical that you keep your routine! Remote or not. Wake up, gym, shower, etc.
I think the distribution channels are exactly what changed - 25 years ago they were only available to large organizations, while now they're free and commoditized.
Show HN: Eplee – Sweet, Simple and Beautiful ePub Reader
okay, I'll explore, thank you. I am not too particular about my salary, as long as I can sustain myself, I am happy. I live a very simple life
Everyone else might still ignore you. Nobody recognizes Abkhazia, even though it's kinda self-governing.
I know everyone is different, and noisy offices can be disruptive to some, but I can't help think that an ulterior motive with working from home is working less.

Maybe work from home will be how we reduce the workweek to account for the diminishing need for work.
The article is about animal research, not human trials. Human trials are not mentioned anywhere in the article. Metabolisms is also not mentioned.

"Both testosterone and estrogen are powerful neuromodulators (12), and so if the potential for intracohort variation in ovarian hormones is concerning, then the same concerns should apply to hormone-associated variability in male subjects. But when male animals made up the majority of experimental subjects, basic scientists mostly considered hormonal variability a nonissue. No one lamented that data would be uninterpretable without careful tracking of dominant versus subordinate cage mates or testosterone assays—any variability in data was largely dismissed as natural randomness. However, when the NIH began to explore requiring its grantees to include both sexes in animal experiments, concerns regarding data variability resulting from ovarian hormones were central to the discussion"

This is the core of the discussion. Something which the article miss to bring up is that part of the basic research into stress hormones came about because a famous case where a medical research into ulcers were mishandling test subjects and got uninterpretable data as a result, which promoted further studies. It also lead to stricter standard in handling of test animals in order to minimize variation of stress hormones (which is also more humane so win-win).

I personally agree with the article that a variation in testosterone should be seen in the same light as a variation in estrogen. If researchers currently dismiss variation of male hormones as natural randomness then it follows that variation of female hormones of the same amplitude carries similar value. The exception is if it is possible to create studies where the variation of hormones can be decreased, in which case single-sex animal studies might be preferred.

In the end however it comes down to the question of natural randomness. A mouse is a very different animal from a human and thus unless there is evidence that hormones will impact the study it might be best practice to treat hormones as natural noise and use animals from both sexes.

< We respond differently to antidepressants

In 1993 National Institutes of Health (NIH) Revitalization Act set a new standard which required that both women and men must be included in human trials in regard to treatment for depression. That fight is 30 years old and has already been won. No one is arguing in favor of single-sex human trials.
Cavulus · Senior Developer (Ruby/JavaScript)
REMOTE· Seattle, Washington, United States · Engineering
( Apply at https://cavulus.workable.com/jobs/1038986 )

Do you enjoy spending time with your family, friends, and hobbies instead of working after hours or commuting? Or perhaps a work environment that plans its deadlines around your vacations, and not the other way around, with management that shields you from the vicissitudes of the outside world and leaves you the time you need for focused, deep, uninterrupted work?

Consider Cavulus. We've put together an all-remote development team and a suite of powerful tools to tackle problems in the healthcare space, an industry notorious for surviving on Cobol, flat-file systems, and old spreadsheets. Studies have shown that 30% of overall healthcare costs are directly attributable to these redundant and outdated processes. We've brought workflow automation, modern data science, advanced interface tools, real-time stream processing, and people together to bring healthcare costs down for everyone.
This is not a honest question, and i m not going to have a political discussion, especially not on HN. I ll just point out it is a subject with a very long history.

https://en.wikipedia.org/wiki/Anarchism

https://en.wikipedia.org/wiki/Anarcho-capitalism
A neural net tries to name cats
The quotes seem unnecessary. Programming isn't just an expert activity. Many applications offer macro recording and other facilities to create programs without scripting. Dataflow programming is often used in graphics and media applications. Spreadsheets are one very successful implementation of dataflow programming.

What Excel doesn't let you do (without heroic effort in support toolchains) is software engineering...
IOMED | Data Engineer | Barcelona (Spain) | Full Time | Onsite

Are you looking for a job with a direct impact on healthcare?
* Problem: Clinical data is messy and makes research slow.

* Mission: To structure clinical data and give unified, standardized access to it.

* Product: Natural language processing models and a data access interface for researchers and companies.

* Traction: Validated idea, Validated business model, growing and scaling stage.

* Funding: +2y runout and growing. Backed by national and international VCs.

* Stack: Python, Dask, PostgreSQL, Cassandra, Docker, and Kubernetes among others

* Values: Scientific, methodic, transparent, hard workers with a HUGE emphasis on work-life balance.

Join a multidisciplinary team of mathematicians, statisticians, bioinformaticians and physicians working hard to make clinical research fast, accessible and ubiquitous. Enjoy Barcelona's vibe and nice weather.

Want to know more? Ping me at rocio.paciarotti@iomed.health
Check our site for more info https://iomed.health/en
AMD | multiple Linux developers | Toronto, Canada | REMOTE | Full Time | https://jobs.amd.com/job/Markham-Linux-Developer-Open-Source...

(Remote possible for senior candidates at certain countries.)

The successful candidate will be responsible for:

* Open source graphics driver feature development based on Engineering and Marketing requirements

* Contributes to software projects of significant technical importance

* Solves complex non-recurring problems that leads to development and implementation

* Driver bring-up and qualification on new hardware platforms

* Debug, analyze and resolve quality and certification issues as reported by Customers and QA

* Write detailed design notes for new features

* Coordinate closely with peers and colleagues to ensure timely and effective communication of all assigned work activities

* Coordinate with developers in the open source graphics development community

Requirements:

* Proficient in C and C++ programming

* Excellent debugging and trouble-shooting skills

* Broad technical knowledge of Linux operating systems

* PC architecture knowledge

* Strong oral and written communication skills

* Experience dealing with customers or Linux community

Nice to have:

* Experience with 3D graphics APIs such as OpenGL and Vulkan

* Contributions to Mesa, LLVM (amdgpu backend), Xorg, or kernel GPU drivers highly valued

* Experience with Linux graphics driver programming a plus

* Experience with open source Radeon graphics driver programming is a strong plus

* Experience with Linux build and packaging tools (make, rpm, dpkg)

* Strong shell scripting and Linux systems administration skills
The comment was about caffeine content, which varies wildly depending on bean, roast, brewing method....