skysight-inc/HackerNews huggingface dataset:
From the journals:

1. Defining the Independence of the Liver Circadian Clock

Mammals rely on a network of circadian clocks to control daily systemic metabolism and physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered hierarchically dominant over peripheral clocks, whose degree of independence, or tissue-level autonomy, has never been ascertained in vivo. Using arrhythmic Bmal1-null mice, we generated animals with reconstituted circadian expression of BMAL1 exclusively in the liver (Liver-RE). High-throughput transcriptomics and metabolomics show that the liver has independent circadian functions specific for metabolic processes such as the NAD + salvage pathway and glycogen turnover. However, although BMAL1 occupies chromatin at most genomic targets in Liver-RE mice, circadian expression is restricted to ∼10% of normally rhythmic transcripts. Finally, rhythmic clock gene expression is lost in Liver-RE mice under constant darkness. Hence, full circadian function in the liver depends on signals emanating from other clocks, and light contributes to tissue-autonomous clock function.

https://www.cell.com/cell/fulltext/S0092-8674(19)30444-1?_re...

2. BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues.

https://www.cell.com/cell/fulltext/S0092-8674(19)30507-0?_re...
This keeps getting re-posted. It's likely thousands of packages are sent to the wrong place every day, Hauwei is complaining to the chinese government about (2) misrouted boxes. This is a non story.
Rechecked some of the more ridiculous mouthwash (sweet ice tea, lemon flavored) and you are right about sugar, its "only" artificial sweetener - saccharin.
Have you ever created anything that you charge money for?
I would argue that proving somebody lied on an application would be easier than proving something like “this person is a danger to the US”. The 2nd is much subjective.
The trouble is, a tape drive can support seek(). But can it support it performantly for all arguments? seek(0, SEEK_SET) is easy. seek(1024, SEEK_CUR) is easy - just read forward a little. But seeking to some arbitrary fixed offset? As far as I'm aware, tape drives are designed to use filemarks for 'searching', not precise offsets.

Of course seek(n, SEEK_SET) could be implemented anyway, in a very un-performant (and tape-wearing manner): by rewinding, and then reading forward n bytes. There's a question of whether the utility of this is desirable when weighed against how surprising it may be to people who don't realise just how bad the performance will be, especially when a tape drive which only supports seek(0, SEEK_SET) can easily have this behaviour emulated on top in userspace by seek(0, SEEK_SET) followed by dummy reads, if you really want it.

read() and write() and seek() prove remarkably versatile, but the niggles come with the fact that different types of file/device on POSIX can have subtly different gotchas with these verbs which, on the face of it, appear to be the same verb. Essentially, I might argue they're not the same verb at all - they just seem similar.

For example, read() from a UDP socket and read() from a normal file have extremely different semantics. If you read() with a 64 byte buffer from a UDP socket, the message is truncated and the remainder of it is lost. This is a very different semantic to reading from a file, where you can read in whatever chunks you like.

I wrote the article upon reflection of precisely this attempt to force everything into the straightjacket of everything-is-a-file that we've had for decades with UNIX. How much code correctly deals with short write()s? "Everything can be expressed as an object on which you can perform read()/write()" can only be true if you ignore the details of a verb's precise semantics, but the precise semantics are important. I think it's fair to argue that write() isn't one verb at this point, but an overloaded verb referring to a set of verbs. Which verb in that set you're invoking is dependent on the type of "file".
I don't think that's true. There was 100,000 years of human behavior before we started to do that (i.e. before civilization and expansion). It seems more like a cultural thing.
I actually see someone calling it a bubble as a good sign. Media outlets are typically looking for stories like this, and even if most of this is close enough to true, it is a new industry and has tons of room to grow.
Not losing any data yet doesn't give justification for such absurd numbers
It is definitely not friendly because social network is a place to communicate with friends or family and you don't want a customs officer putting their nose there.
in that case I too have run out of air at the "bottom of the ocean"
While I get the moral argument here, I'm going to go with the market signaling. Hollywood can get its shit together and make something that's convenient, or it can die. Either choice is fine by me, and I'll figure out how to integrate piracy in my moral framework later.

The future I want looks like what GoG is for games, or Bandcamp is for music.
Good luck with your pension fund then.
I tried the switch a couple times. A few times with spacemacs, a few times with trying to write my own config from scratch with evil. Not sure what it is, maybe the way emacs configs are setup but I found vim just so much easier for me to manage with less magic and more predictability.
I'm surprised the US was still the most competitive economy. The amount of trade barriers especially to skilled people migrating seem higher than most places.
As I understand, those questions are for tourists too, not only for people wanting to live in US.
What Is Fire? (2018)
Thanks to surgery in the womb, newborn avoids devastating birth defect
Bitcoin has an inflation rate of 4% at the moment, dropping to 2% at the next halving in 2020.

Similarly, gold has a vault storage cost of up to 1%, and a mining inflation rate of about 2% (3 kt/yr on a total stock of ~150 kt), more if you just count tradable coins and bullion, without including jewelry.

I would also expect a cash warehouse to cost ~1% for storage, security and insurance.

Bank charges, such as ATM fees, can take the spread and transaction cost for cash up to 1%.

So NIRP can easily go to -1%, and maybe even -2% before the alternatives make sense.

However, I would expect a speculative rise in price for BTC and gold in the initial stages of a globally coordinated policy of NIRP and a War on Cash.
So many?

As someone who went through the H1-B process and had my status threaten a number of times (downsizing), it was just a reality - if I lose my visa I go back home and maybe try again.

It never stopped me from major live decisions like buying a house.

Immigrating to a new country is taking the risk that you can’t stay. I accepted that when I immigrated.
Because monetary policy is more effective than fiscal policy?
I think some Google engineers published a free Meap book on service relatability and uptime guarantees. Seemingly counterintuitive, scheduling downtime, without other teams’ prior knowledge, encourages teams to handle outages properly and reduce single points of failure, among other things.
> taxation and public spending

the rich would bear the burden if taxation and public spending is used. They don't want that. And guess who has enough resources to lobby and PR it?
It's not about losing a few kb here and there.

It's about losing entire data centers to massive natural disasters once in a century.
The beginning certification level is 60 feet. You unlock the deeper limit after additional training, and it includes performing a three-minute "safety stop" at 5 meters. 60 feet is about as deep as you want to shoot to the surface from (and if memory serves the limit they give in training is 30 feet, or 2 atmospheres).
So is PornHub considered a social media?
I had an avocado tree in the backyard growing up and the avocados would fall and grow new plants.

The next avocado you eat, leave it in an inch of water and it will sprout in a couple weeks, splitting in half to extend roots and a small canopy.

Had I not had to weed the backyard as a kid during avocado season, the plants would've kept growing from fallen avocados. They have these massive yolks that let them grow pretty much anywhere, as long as they find their way to some soil after a while.

I'm sure megafauna gave them a nice travel system.
More than 300 Boeing 737s to be inspected for faulty parts
A rose inspires smart way to collect and purify water
You either let people in or not?

Most countries have a graduated immigration system - you start with a work visa, you try and get permanent residence, then try for citizenship.

The US isn’t alone in this except for maybe the fact that the demand to immigrate to the US far outstrips the limits.
If he was pranking a friend or something that's one thing, doing it to a homeless person is just sickening and disgusting. Punching up vs punching down - punching at your level or up might be funny or at least just stupid, but punching down is abusive and revolting. He deserves every second of those 15 months, shame he apparently likely wont serve it if I read the article right.
We still cannot repair a spinal cord injury. A complete decapitation is a total spinal cord transection and more.
Except kicking the door down is not particularly scalable or clandestine
memory complexity in JS translates into time complexity needed for GC cycles.
It's definitely interesting in that this is a great example of the "when elephant's fight it's the grass that gets trampled".

Amazon trying to battle Google results in chx's purchased hardware not being supported by Amazon's service despite the fact it's a very standard streaming device.

It by no means gives any rights to breaching intellectual property laws, but Amazon are making a commercial decision to leave out Chromecast support because they believe it'll make them more money overall, with the express knowledge that it could drive some potential customers to alternative methods, which includes breach of intellectual property laws ("piracy"). It's not like "piracy" isn't known to be a potential option when the likes of Amazon and Google and all the others make business decisions.

No, it's not a justification of illegality, but it's an understandable position to take as an offset.

Definitely interesting on both sides.
You've demonstrated a lot of good faith engagement with me. Thank you.
You could buy a $300 PS4 or a $250 Nintendo Switch... Honestly Doom isn't a taxing game and might run on a MBP with boot camp or in a VM.
The only thing a customs official is going to see is your public online persona. If you don’t want them to look at it maybe it shouldn’t be public?

Of course then could go the next step and ask for a password (which I would argue goes too far).
Just do step 1 in reverse.
Whoever would have gotten the royalties from watching that something else on Hula would not get that if instead he pirated the movie he originally wanted to watch.

This aspect is often overlooked when people analyze the impact of piracy. People just look at the sales of the seller of the pirated item, and so if it costs $X and $X is more than I am willing to spend, my pirating won't cost them a sale because there was no scenario in which I was going to buy, and so no harm was done to that seller.

But in the case of entertainment products, if piracy is not available I'm probably not going to simply forego entertainment. I'll instead look for something that is within my budget and entertain myself with that instead.
But even if all of your 10000 identities are innocuous, perhaps disclosing as many as 10000 identities itself get get your visa rejected.
someone tried to kill me for exposing them raping my girlfriend and the doctors used experimental oxygenated blood to save my life. I got really drunk the night i was assaulted because of a related incident. During the incident with my gf, her ex and i were trying to locate her after a party (we were in another dorm and she called us on a cell, not hers) and she recollected she didn't know where she was, she was naked, and that some males were holding her close not letting her go. They would only give her clothes after a sexual act was performed. We tried locating her but we were too late. Afterword, I and the girlfriends ex tried pulling the call 'metadata' but it was deleted or i was not allowed to access it.

I have a higher likelihood of suffering a stroke in my 30s due to the fake blood injections.

My roommate was paid to keep watch while the offender tried to suffocate me. While transported to the hospital i lost consciousness for a long time. The hospital pretended like they had consent to inject me with the fake blood. The hospital covered up the rohypnol in my system. The nurse there assumed i tried to slip a gril a roofied drink and failed. The college buried the report, blaming it all on me. My parents were shamed. My girlfriend ended up dating the offender for 2 years due to violent threats on family. The offender got away with sexual assault against me (buck breaking). The offender stuck his dick up my ass so I wouldn't tell anyone of the event (i am male and it almost worked). The only reason I survived is that I pretended to die (thanks burn notice) only for the offender to realize he didn't want to kill anyone. I had a brown-out of the events for about 1.5 weeks after. This will be my greatest shame for the rest of my life not trying harder to prosecute the incident.
3% should be outlawed. If you sell your house for exactly the price you paid for it, you would have just lost at least 6% to realtor costs. Even more when you consider expenses like title insurance, taxes, and other fees.

Anything less than 10% is insane, and less than 20% means you can’t afford it.
It seems to me like there's a mismatch between the traditional sports business model and esports. E-sports may not end up looking like the NFL. It could just be individuals with huge followings. Instead of teams that pay for housing and training and salaries like the NFL, esports teams will just have administrative staff and not much else.
I appreciate where you are coming from. Many people understand that, physically, 'pirating' is more akin to copying than taking though. ..And then there is an argument that increasing the availability of content increases the revenue of the producer in the long run. Some game developers and many musicians are even releasing official torrents of their content, assuring quality control. I'm curious how this would work out if bigger studios dabbled with it.
> I decided to switch to a reddish tint after my first failed attempt.

What happened with the first attempt?
Texas Bans Red Light Cameras
Most CPUs have used 42 bits for quite a while and only recently has Intel been making 48 bit addressing CPUs.
When you're placing words in my mouth, like you did before, I'd appreciate if you kept the distinction intact regardless of how you feel.

As for supporting them, in the abstract sense of "their ours" and in which I support the leafs (terrible hockey team that people from Toronto feel obliged to support), probably so. That doesn't mean that the people (especially in China) are responsible for the governments actions, that they would do the same thing given a choice, that I feel the same towards the two entities, etc.

If you're not in favor of anthropomorhpizing nation states translate "China's actions" to "The current Chinese government's actions" and not "The general population of China's actions"
>and the consequences and side effects of calling write are so diverse (from flipping bits on a harddrive to triggering arbitrary code execution) that it is all but guaranteed that something will go horribly wrong.

This is why I suggest we really need the ability to dynamically add new verbs. POSIX has one write() but in terms of semantics it's really a whole family of verbs as one overloaded method.

>The file system itself needs to know about the new type of object that it is going to represent, rather than simply acting as an index of paths to all objects.

What I had in mind was that a given filesystem driver (e.g. a userspace FUSE process) would provide object types it supports. So for example, a "printer FS" process, printerfsd, would provide printer objects under e.g. /printer/. But the vfs - the layer that does prefix matching on mount()ed filesystems wouldn't need to know about new object types, as it's just a dispatcher.

One shortcoming of this is that you can't mv /printer/foo to another filesystem. That's also a shortcoming of e.g. today's /proc or /sys, but there still seems to be enough that's worthwhile about this approach.
Is that convention documented anywhere? It’d be quite helpful to me.
I'm not sure what the underlying legal theory is in defining terrorist groups, but maybe ex post facto applies here. If the defining of the group as terrorist is done by passing of a law then this is pretty open and shut. If it's done by executive order then I'm not sure. It might go to the supreme court.
Yeah, I think that’s part of it. I understand that a lot more people want a place to live than want the newest phones, that no one wants to live next to bad neighbors, that people like having guests and competing for status, that land close to major cities is finite, etc... but it still seems weird that people are charging more money than what people actually have. If you took loans out of the equation, part of me thinks houses would start reflecting people’s actual needs and means better and would drop significantly in price. Eventually I think they would provide people with a sense of security rather than obligation since you’d have to buy them outright, and eventually that security would result in more creative/entrepreneurial activity. But maybe I’m just severely undervaluing all the work required to build a basic house/overestimating how much the process of building them could be streamlined so as to avoid loans.
Let's suppose that I have an HTTP endpoint for a doorbell (for some reason). The doorbell resource is represented as http://example.com/doorbell.

There's no RING HTTP method, and I could invent one, but heaven knows if various HTTP middleware would be happy with that. In practice, people do something like

POST http://example.com/doorbell/ring

The problem with this is that you now have a hierarchy of verbs; you have first class verbs (GET, PUT, POST, PATCH, DELETE), and second class verbs which have to be represented as distinct resources. This feels like a hack to me.
Besides your personal opinion, I see no reasons cited to bash keto. There is good data on supporting its health effects. Any possible effects on "the planet" are orthogonal to its healthiness.
Flash freezing (using liquid nitrogen to freeze something really quickly) is used successfully for smaller objects, such as frozen berries and frozen vegetables that you can buy at the grocery store. The Wikipedia page on flash freezing links to this [0] site with some more discussion. The Wiki page also says that flash freezing still can take a few hours, so there are still ice crystals created, but a lot less/smaller than if you just put it in the freezer.

Overall it seems it's just a matter of waiting for technology to advance to the point where we can very move a 150 pound 2-meter-tall 1-foot-deep object from 98 degrees to 30 degrees, and at that point the science fiction will become reality.

[0]: https://web.archive.org/web/20120111233417/http://www.biotec...
I don't understand the need for negative interest rate. Having the rate set at zero is already bad (it means that your savings erode at the maximum rate). People who are in a position to borrow would do so, and make gains when there is a recovery, while people who can't will be left behind (but i guess this is where the crux of the inequality comes from in the world).
Bubble solution is glycerin and not a great cleaner. It is also very safe. You could at most say it is hand soap and a toy.
Such an app might first get accepted into an app store (by accident), but it would surely break the rules and get taken down pretty quickly.
From the perspective of American society, yes.

From the perspective of Native born Americans, no. Because these skilled workers would be competing for similar jobs.

However, it’s possible that the Skilled Immigrants + Native Born Americans create a synergy that works even better, so IDK. It seems hard to do thought experiments with this stuff.
I think esports will take off once a modern popular game allows local communities and neighborhoods to host what we used to do with lanparties.

Part of what helped propel traditional sports into ubiquity was the ability to have a ball and play anywhere with anyone you choose which allowed schools to build teams with practice fields and community leagues etc...

Modern games, at least as far as I can tell require you to connect to the IP holders company’s servers and often don’t allow you to pick and choose specifically who you play against which in turn makes it nearly impossible to build leagues and do team scrimmages, team practices, local community leagues, etc...

And the other major issue I see is the lack of quality spectator features in games.

My friends had a LAN party a few months ago and we played some older game, quake3osp(?) Its definitely old, but it seemed to have the kind of setup I imagine it would take for a modern game to really become as prolific as traditional sports. It had amazing spectator functions where you could jump from player to player at will, it had the ability to host the server yourself, you could trade players from the sideline onto your team at anytime, you could pause the match, you could practice on any map you wanted, you could pick a map and run around for an unlimited amount of time practicing, etc.. etc...

Modern games require too much interaction directly with the companies who control the IP for them to ever really take off.

Could you imagine if neighborhood kids playing football didn’t have the freedom to just run around the same field for hours and play against the same other team for hours? And were required to only play when everything is controlled by the Professional league who controls the nfl or mls branding? It never would have flourished.
Since you have actual first-hand knowledge of border officials doing social media questioning, could you tell us more about this? What did they ask her? What prompted them to print out the social media pages? Which social media sites? What country was she coming from? How long did they question her?