skysight-inc/HackerNews huggingface dataset:
> We need to end off label use. Saying a drug is approved for one diagnosis and then allowing it for any other diagnosis is, in the modern age, simply crazy. One might as well not have fda approval.

This is patently ridiculous. The FDA just proved the drug was safe in therapeutic doses and that it treated what it said it treated. They didn't say that the drug wasn't safe to treat other things, and they didn't say the drug was generally unsafe. If doctors are prescribing non-therapeutic doses, yeah, that might be a problem, but there are entire clades of diseases that would otherwise be untreatable without off-label use. (And the frank alternative - labeling all of the drugs as being usable for all of the various conditions - can't keep up with reality. The FDA is slow and meticulous, and if we forced that on off-label used drugs, there'd be a lot more suffering for literally no good reason. And it probably wouldn't do anything for actually stopping off-label usage - doctors would just start lying and overclassifying their patients as having diseases to give them the meds. E.g. there'd be a whole lot of autoimmune patients with various "overlap syndromes" that suddenly have lupus and/or rheumatoid arthritis, despite not meeting the current diagnostic criteria, just so they could keep taking adalimumab, methotrexate and/or hydroxychloroquine. It's just red tape they don't need nor care about.)

We've done actual wonders in the world by simply scanning through approved drug combinations to find treatments for ailments. An example of this is in cancer treatment: it's fairly common one cancer drug will treat multiple classes of cancer, especially in combinations with other drugs (even ones not designed to fight cancer specifically). It's so commonly the case that this is now its own entire enterprise: high throughput scanning of drug combinations to fight tumors. https://www.biorxiv.org/content/10.1101/051698v1.full It's also been done to treat viruses and autoimmune diseases.

I'm not a super libertarian or anything, but I believe if a doctor has a reasonable belief that a drug will treat a condition, and therapeutic trial evidence bears it out, there's not a good reason not to prescribe it, whether or not it says on the bottle that that's okay. I've benefited from this in the past and I will continue to in the future.
author here. we wrote this article keeping small businesses/startups in mind. it starts from really basic stuff and gradually introduces complex concepts. this article aims to be a living document to backlinks. We'll keep it updated.
It's one of the things I have on the back burner, I personally believe that WASI doesn't go far enough. WASI limits filesystem calls to the actual filesystem for one. I think it's better to have a homogeneous view of things so that the only difference between local and remote resources is what the platform does.
We've already asked you several times not to post like this. It breaks the site guidelines. We're here for curiosity, not flamey rants.

https://news.ycombinator.com/newsguidelines.html
Bad news, that talk has been a constant source of inspiration for my entire endeavors :)
> You’re right that number of blocks until transaction is considered safe is arbitrary but you can’t just arbitrarily raise this number to compensate for lower difficulty because interval between blocks is 10 minutes and so in effect you’re reducing usefulness (and value) of the whole transaction system.

Yes, I admitted as much, but it's not a linear value relationship. There's a point where difficulty that is "too low" makes the system unacceptably vulnerable, but at that point the coin must be almost worthless and the incentive to be a malicious actor is equally low. There's another point where difficulty is high enough that for all practical purposes, a malicious actor has no chance of turning a profit. No further increase in difficulty beyond that point adds any value. Bitcoin is well past that point.

I wouldn't rule out that the belief that "more difficulty = more security" may cause certain people to go bullish and buy, therefore driving the price, but it's not such a direct relationship as price vs. cost of mining.
Okay, so if we store a three-bit 5 as 101 (in columns 0-2) and an additional "non-null" indicating 1 in column 3, we're saying that we have a row that has an association with columns 0, 2 and 3, but not with 1. Since, you know:

> The central component of Pilosa’s data model is a boolean matrix. Each cell in the matrix is a single bit; if the bit is set, it indicates that a relationship exists between that particular row and column.

But why do I want my integers sliced apart into these associations?
Primitive Technology: Polynesian Arrowroot Flour [video]
Right, and Twitter used to force them on everyone. Escaping to another reality doesn't solve problems.
This is a huge step backward for Indian science and it's really sad to see. India already is far behind China and not even comparable to the US or Europe. Now they'll fall far further behind.

You don't get your PhD in US/Canadian/European universities without publications. Not in physics, math, cs, psychology, neuroscience, etc. Publications don't just show you can do things, but they hold your advisers to account to make sure they're also pushing out new ideas, they hold entire departments to account. If a department can't produce enough new ideas and research to get 1 paper per PhD student out, then they are failing and should be dealt with by the university administration. Failing to graduate PhDs is a critical metric in finding such problems and dealing with them.

What this does is just entrench India's failure in the research world. Lazy senior researchers will get lazier. Young researchers will have far less incentive to keep moving. Departments won't be held to account anymore. And low-quality PhDs will keep being minted.

I'm not a fan of publish or perish, and it's damned stressful sometimes. But 1 paper per PhD student is not a burden. It's a bare minimum and advisers should be ashamed if this is all that they can publish with a student through their PhD.

India is pumping out huge amounts of junk research, mediocre PhDs, and is just stagnant overall in research. This is short sighted, lazy, and will hurt everyone there.
I would say it's not. There's many advantages to hiring remote workers, they've been discussed at length elsewhere. One advantage is not having to pay office space, which indeed lowers cost. However DO has a nice office in Manhattan so really... they're not saving much money. And then on the term of compensation, for some reason DO pays it's remote employees really well. I don't know how this changed in recent years but people in NA and EU are all paid handsomely despite being remote. I don't know about other locales.

The reality is that top talent, even if remote, is competitive whether they are in NYC/SFO/SEA or not. And DO has some pretty talented people on staff.

And then, having people in all timezones is definitely an advantage for 24/7 support. I'd say it's not negligible, and not an after thought.

Now about english fluency, it's only that important to english native locations. And really, most of tech does not necessarily have english as a first language - I certainly don't. So I'd say that encountering support engineers with imperfect english shouldn't be a problem to anyone, and definitely not a sign of cheap labor. In fact, I'd say bitching about someone's english proficiency in tech is kind of counterproductive and I find it discriminatory.

Anyways. DO doesn't hire international employees to get cheap labor, that's a preposterous proposition. And with datacenters around the world and a large presence and customer base, it makes sense to have staff on board from many of these areas. And that staff might answer your tickets at night when they're on shift. Shouldn't they?
Employers get to deduct health care premiums from pre-tax, whereas freelancers have to pay for premiums out of their after-tax income. It can make a fairly big difference if your marginal tax rate is high (which it probably is in CA).
In the UK we have IR35 legislation which the government, in its wisdom, is using to cast an ever widening net around the contracting sector. It's become so farcical that a lot of contractors won't touch anything in the public sector while public sector recruiters are bending over backwards to convince contractors that what they're offering is "outside IR35". So the government is effectively trying to find ways round its own stupid legislation. One of the factors which helps mitigate IR35 is a substitution clause, ie. you're replaceable.
Maybe you do, but the vast majority of people do not. In that respect you definitely are an outlier.

Most people don't understand the value that comes from user data, and the potentially damaging effects it might have on their life (Facebook can detect that you are homosexual through your Facebook usage, and if you live in a country where they kill homosexuals you are going to be in serious trouble). Almost no users understand the impact of the third-party doctrine.

There are all sorts of other issues. If you talk to someone suspected of being a terrorist, then you are labeled as a suspected terrorist. Since this bill is about browsing data, if you read articles If you read articles that are seen as being objectionable (imagine reading articles about communism during McCarthyism) then you might be labeled as such even if you were reading them for purposes other than indoctrination. There is a reason that a court order is required to get the borrowing records of a particular library user and libraries cannot sell that information.
Anecdotally, I find phenylephrine to be definitely effective as a topical decongestant (nasal spray); especially more so than its alternative (oxymetazoline), so it's not a placebo effect. But I agree that it doesn't do a thing as an oral drug.
The port status for the 6G does look pretty good, though.

https://www.rockbox.org/wiki/IpodClassicPort
I vouched for this comment because I didn't go into detail much in the talk. The main idea is to remove a lot of the kernel and related overhead from application code, kind of like an exokernel. I am working on using seL4 as a base for an OS that only runs tasks in WebAssembly. Having things implemented such that the OS is not a fundamental linking requirement means that I can easily port applications to the browser. I don't have a working sample at the moment though, I somehow broke my last ones and haven't had time to fix them yet.
Would that imply that unwelcome babies are more likely to become criminals?
It really is a trivial amount of resources to have it triggering such a reaction. It's almost like DigitalOcean doesn't like being in the cloud hosting business. One of the fundamental, desirable points to the shift to such cloud hosting services is that you can quickly spin up a bunch of resources when needed and then dump it.
No such thing as one standard Mini USB. I worked at PC parts&accessories supplier pre 2007 and we carried something like 5 proprietary variants of mini USB.

The only way to match "mini" USB was to ask for particular brand or make client bring the device with him. 5-pin, 4-pin, 8pin Nikon, 4pin Sony, etc. It was a mess.
maintaining a certain level of testosterone in the human body
> I'm pretty confident that I understand what i'm agreeing to.

Ok, let's explore that. Can you describe, completely, what it is that you are agreeing to? And just so we are speaking at the same level "I agree that you can do anything you want" isn't a meaningful consent.
> Rebuilding it in concrete would see the French in uproar.

The French are always in uproar.

Only half joking.
Can someone knowledgeable in this area lay out some of the potential anti-trust points that could be shown by the probe?
> The connectors become loose and come out with little resistance.

Seems to me on laptops that's a good thing, so if you trip over the cable the connector is more likely to come out, than the laptop crashing down?

I don't really ever move my laptop around while anything is plugged into it, so I think that's the right tradeoff.
Question is if you can trust a three letter word in a resume to _any_ degree at all, or do we always need to devolve to going back to reading the entire thesis to get an opinion of whether the person did good work.

Not to mention, at the low rungs of Indian phds you would not even know if the thesis was just plain plagarized work from somewhere else. That is actually super common, even in publications.
It's defined as 3 differential equations. So you use some multipliers and summers to calculate those 3 equations and feed those into 3 integrators. The integrator. Outputs are what you plot on a scope or listen to. Use pots for the variable gains in the equations.

Ahhhhhh analog.
>at minimum 3 different GHC extensions. So I may be biased.

are you kidding? most files i see have all of these

http://dev.stephendiehl.com/hask/#the-benign
Yes, because telling someone something in confidence is the same as sending a fucking email. You are reaaaaaaaally making an effort to look obtuse.
you can go fuck yourself.
Would also like to know if there's a resource like this out there.
Does AWS AppSync even play the same game as Hasura?
If those employer group rate things didn't exist, the whole system would be different. The insurance companies would still want peoples money, they'd just come up with some other arbitrary way for people to group up or do away with the grouping all together (which is how it should be).
Yeah that's my company. And we're all employees with healthcare, retirement accounts, workers comp, unemployment insurance, and FICA withholding.
They exist as distinct words for a reason. The difference is important. Search "complexity vs complicated", I even found a few articles about it right here on hacker news.
So true! Well written, to the point and kept up to date.
I don’t. I think the iPad doesn’t have to replace 100% of laptop uses.
One minor difference: The permanent record was an official document. Twitter mobbing is a failing of our private citizens.
I'm curious what folks who think that TNC drivers can't possibly be independent contractors think about this.
In the UK we have umbrella companies who take care of accounting, payroll etc. for a fee/percentage of income. Don't these exist in the U.S.?
Dude, it's not a conspiracy. https://www.eff.org/nsa-spying
Gonick's "The Cartoon Guide To Computer Science" would be my first stop for inspiration. Though somewhat dated, the fundamental concepts and history it describes are still sound.

https://archive.org/details/TheCartoonGuideToComputerScience
Again, I don’t have a clue what I’m talking about. But I seem to remember seeing a lot of those “dangerous” ones. If that’s just the state of Haskell, my bad.
It's always sad to see these stories because they always seem like a preventable tragedy. DigitalOcean, Azure, and AWS seem like the go-to for start-ups these days, instead of self-hosting your stuff at home or even in a colocation space. Even though it's a "dirty word" these days, on-prem does have its huge benefits.

Professional stuff is one thing, but that's not to mention anything personal - anything I care about I won't put exclusively on someone else's computer. I want to have absolute control over as much of my stack as I can. Seems really scary that some company has control of your entire infrastructure and can ban-hammer you without notice, permanently, at any time of day or night (or while you're on vacation).
Now in the US, building codes are allowing construction of buildings of 6 stories with only the first being concrete and iron, and the upper 5 wood frame with neither concrete nor iron structure, and such buildings are proliferating. Is this CLT a part of the rationale that such structures are acceptably durable?
So?

New York's MO is "screw over people now and settle out of court in 10yr if you think the precedent isn't gonna go your way."

A lawsuit or twenty won't stop them. It's not their money.
fuck you cunt.
>closely examine Google’s business practices related to its search and other businesses

Not a lot of detail.
What's the difference between "OUGHT TO" and "SHOULD"?
I have for a long time believe that the entertainment value provided by the internet and connected devices should not be overlooked when considering factors that contributed to this decline in crime during this period. Just having something to entertain people can help keep them out of trouble.
I like prgmr.com’s motto, “expect about $5/month in support”
That's a good (although bad for the consumer) point. Are you aware of any examples of this happening?
This is not the first time DO has done things like this. I would not trust DO with anything critical, and have advised people in the past to not use DO. Nothing here surprises me.
Much Changing at Coinbase. COO Leaves
One of the big problems with USB-C is that both sides of the connector can get filled with lint. The good news is that it is pretty easy to clean out, just take a needle or safety pin and scrape out the lint. It will be extremely compacted from you trying to push the cable in all the way over and over, but if you keep scraping I will bet you pull surprisingly large lint chunks.
Well, not locking you your account for false negatives and unlocking it when you ask for it should be in the free support plan of any company. No one pays to get locked out, support plan or not.
The world that billionaires live in is just so difficult to fathom. They literally need nothing since they already have multiple mansions, jets, yachts, etc paid for sitting there waiting to be used. Yet they still have access to hundreds of millions or billions of dollars, so spending a measly $13m on a car is literally nothing to them. No need to even blink at the cost. What a crazy world we live in...
I have news for you, most corporations are unethical because they are not people they do not care for ethics they are literally money making machines and Google is great at making money.

I'm not a Google fan and welcome this investigation but you need perspective.
With all the comments about broken on Chrome & Firefox, where does this work?
US government operates on a number of bases -- not all rules are based on legislation.

Generally, by order pf precedent; Constitution, case law, legislation (US Code), regulation (Code of Federal Regulations), and executive orders. Plus others, such as court procedure, prosecutorial discretion, and more.

LLI's resources at Cornell University are a good start (though not a complete list).

https://www.law.cornell.edu
I am generally a pretty left leaning person on social & financial issues. But I have to wonder on a kind of larger scale, do these democrats who want to raise taxes really make sense?

I get that it would be nice if we all lived in a more equal and egalitarian society. It would be nice if we had social safety nets and better health care and all the rest of it. It would be nice to live in a country where we take care of our sick, and old and homeless.

But in the cold light of day, does anyone really believe that this tax, or any tax or any amount of money whatsoever, is really going to change fundamentally anything about the United States? It would be nice to think so. But as a pragamatist, I sometimes wonder if it might be time to simply accept the fact that the United States is a cut throat, profit seeking, pro-business, anti-safety net kind of country. I mean, honestly, are there really going to be fewer homeless people on the street after this tax? Is healthcare going to work again? Probably not.

I’m happy to pay taxes when I believe that the money will make a difference and actually improve someone’s life. But in a country that insists on spending untold billions on “defense” honestly, wouldn’t it be better for us all to keep more of our hard earned money? I wish I didn’t see this so cyclically, but I just don’t see the US changing very much, no matter who’s president and how much taxes they raise.
Extra bandwidth for the same amount of money is effectively a discount.
Why would they, if they know someone will cost them a lot of money then what incentive do they have to ever insure them for non-exorbitant amounts if they can avoid it? Every other form of insurance would either not insure them or charge them massive fees (home owners, renters, life, car, etc.).

Group rates are a hack if anything and insurance companies have no incentive to make less money by having their own version of it.

edit: To explain further. Let's say insurance company A has a group plan and B insures people individually. A is then forced to charge half their clients more than B as the average rate is identical. Thus it's in those people's interests to move to company B and pay less. Now those left on A's plan have even more average risk (as all the low risk people have gone to B) and the rate needs to go up. Rinse and repeat until A has no clients or is bankrupt.
The Roaring bitmap paper is equally opaque in this regard. I easily understand everything about the bitmaps themselves: the compression and various operations. But then they say that they tested it on some Census1881 data, and I'm thinking, what, how? How do you grind census data into a bitmap? And is everything in the bitmap, including people's names and such, or does the bitmap refer to objects that are not in the bitmap?
I am from India and here writing skill for engineers is not valued at all. As someone into research, I found it important when I started sending papers. Academia here is not giving importance to the writing of its students.
You are absolutely right. I checked wikipedia ([1] and [2]), and it turns out that the mass of whole asteroid belt is only about 6 times as high as the mass of the Venusian atmosphere, and half of this mass is taken by the top 4-5 asteroids, which arguably we wouldn't want to start flinging around the solar system. Moreover, most of the asteroids are far from the Kirkwood gaps (almost by definition), so if you want to nudge them you would lose a lot of mass to ablation.
I guess he meant they don't lock your whole account but only stop a single server.
> but much true freelancing seems incompatible with this law.

If you're a true freelancer with multiple clients you have generally nothing to worry about.

In the past I've had clients where I ended up just working on their stuff and after a few years they ended up just hiring me full time. That is totally normal for non sleazy companies. Then you have companies that try to get out of paying the costs associated with normal employees. These companies are all skeazy and deserve to get slapped.
Where on earth did you read this? Testosterone levels are mainly the result of your hypothalamus’s response to circulating levels of testosterone in the blood. Lack of sleep, large alcohol consumption, stress all cause the brain to down regulate the production. Exercise causes it to be upregulated. Food probably has a very small effect on your day-to-day levels.
Broken Edge Dev Windows and Android
Not sure what you’re talking about? Why would the image be bug ridden?
Plenty of non-wealthy people build one-off/low production cars that would fall under the same umbrella: restoration and replicas of classic cars, kit cars such as Caterhams and Westfields, custom coachworks on frames, etc.

In the U.K there are regulations and processes for checking the road worthyness and safety for all of the above: https://www.gov.uk/vehicle-registration and http://www.legislation.gov.uk/uksi/1986/1078/contents/made
I agree with your medical analogy.

Like I said, there’s a range of work at JPL, and some of the autonomy work by the linked group most definitely has run on Mars and in Earth orbit.
For anxiety at least, benzos like xanax are extremely effective. If they weren't addictive, chronic anxiety would be pretty much cured.
most of them are well written. It’s the community though, not DO
It could be squared off, or some weird shape, the way mini and micro USB were.