skysight-inc/HackerNews huggingface dataset:
See, this is a major problem with fee-for-article access to journals. 10 journalists talk to the author (or does the author contact the journalists?), the journalists feel confident enough to write an article, there's a headline, some callouts, and then there's some metaheadline on another site with commentary virtually unrelated to the original details. For the sweet love of . . . did anyone not think that the synaptic structure of a human neuron might be a smidge more complex than that of a fruit fly?

What's really sad is that most people here could understand the article perfectly well if they could only access it. If you want to be understood, publish in an open-access journal, like PLoS.

Here's the [link to the paper](http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.213...), and the abstract, below

>Evolutionary expansion and anatomical specialization of synapse proteome complexity

>Richard D Emes1,6, Andrew J Pocklington2,6, Christopher N G Anderson3,6, Alex Bayes3, Mark O Collins3, Catherine A Vickers4,5, Mike D R Croning3, Bilal R Malik2, Jyoti S Choudhary3, J Douglas Armstrong2 & Seth G N Grant3

>Abstract

>Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs) that underlie learning and memory. PSD and MASC orthologs found in yeast carry out basic cellular functions to regulate protein synthesis and structural plasticity. We observed marked changes in signaling complexity at the yeast-metazoan and invertebrate-vertebrate boundaries, with an expansion of key synaptic components, notably receptors, adhesion/cytoskeletal proteins and scaffold proteins. A proteomic comparison of Drosophila and mouse MASCs revealed species-specific adaptation with greater signaling complexity in mouse. Although synaptic components were conserved amongst diverse vertebrate species, mapping mRNA and protein expression in the mouse brain showed that vertebrate-specific components preferentially contributed to differences between brain regions. We propose that the evolution of synapse complexity around a core proto-synapse has contributed to invertebrate-vertebrate differences and to brain specialization.
Agreed, this makes little sense. As time goes on, someone's ability to maintain a system (assuming it is something that only he could do well when he was there) quickly approaches zero the longer that person is not involved with it. What's the realistic limit on this anyway, or when will Blaine no longer be mentioned in relation to twitter? At some point, it's all the current employees' burden to bare.
As far as the power supply fan is concerned, their manufacturers don't care about improving its efficiency. This is because you are not the real customer. Dell, HP, et al are. When they place an order with the metal-bending shop in China, all they care about is price. If putting a more efficient fan in the power supply is going to raise the price by a few pennies, they won't be interested.

The only way anything that the high-efficiency power supply is going to fly is if it is going into a high-end product.
I only ran the initial architecture & buildout and then moved to sysop as they hired people. The rest of the business was not my business. :) After a good few years we hit financial trouble and were bought up by Yahoo for pennies.
"Dial 800-GOOG-411 : spectacular speed, convenience and reliable"
Mobile Social Apps is the future trend
High vs. Low Design
Although I am fortunate because I can say that nothing like this has ever happened to me, my sincerest, warmest condolences go out to you and your roommate's friends and family. I cannot imagine what it must be like. I hope you find strength and light in a time of darkness.

I wish you the very best of luck on both your last year of college and your startup; enjoy them as much as possible!

Let us know if you need anything - I am sure I speak on behalf of the YC community in offering you our heartfelt support and assistance.
Actually, the complexity of synaptic structure between species is not obvious (and hence, this is one reason the article made it into Nature Neuroscience, a highly regarded journal). Since the neuron is the fundamental unit of the nervous system in all species, it is a decent prediction that it is of the same "complexity" across all species.

I do agree that articles should be published in open-access journals. However, most people here probably could not understand the article well (no offense to HN readers!).

You really do need a very good biology background to even understand the experiments or to interpret the conclusions and their reliability. In addition, scientific articles are very dry, and if a journalist did not simplify it for you, you likely (1) would have missed the big ideas (which are often phrased in scientific jargon), and most importantly, (2) would have never read the article in the first place!
Sorry for your loss. I'd suggest taking a short break from the startup to focus on finals and getting through this tough time. You'll know when you're ready to get back at it.
God bless. Nothing more embarrassing than sending a drawing of a booger to all your contacts when you really didn't want to.
I'd hate to give you advice that I know won't work, because I've received the same in the past. I can only tell you what I've learned from my experience.

Last year, as finals were approaching, I would drive up north every weekend to see my grandpa in the hospital. He was suffering from a bad case of kidney failure. It was an immensely stressful time of my life, ultimately ending in him passing away the weekend before finals. We were extremely close. After hearing the news, attending the funeral, etc., I realized I hadn't cried much, and thought that was weird. I was bottling up my emotions thinking that is was the 'manly' way of coping. What happened was that I had bottled up so much emotion, that the bottle couldn't contain any more, and every so often the bottle started to leak emotions, and I found myself in periodic ruts of depression. So the lesson for me was to just mourn.

So, just mourn. Of course, realize that you have responsibilities and goals that need attention, but if taking time off will help you cope, then so be it. Face the situation and don't try to run around it, because it will catch up with you.

My condolences.
Take time to deal with the emotional side, the milestones can wait.
Mmmm... leaky abstractions. That's where frameworks will getcha.
That design is money - Designing ATM interface
(Playing Devil's advocate here)

So an appeal would be turned down. The more info that is floating around out there that makes him seem guilty the better.

Also, I think it's wise to ignore all this talk of "unnamed sources". We have no idea what their motives are, or even if they speak the truth.

Btw, I think Reiser is guilty, based on what I read about in Wired (which had very good coverage, IMO).
I've had a close friend of mine taken in a very bad way this past year, which also happened to be my senior year of college. Luckily for me, she was not only my friend but very well known throughout our community and we all came together to mourn our loss AND celebrate her great accomplishments. I still think about her often and hope to live by the goodness she represented. I've gotten to think of the entire event as a blessing in disguise, as our loss has now brought us together and caused us to reevaluate our goals, principles and lifestyles.

My sincerest, heartfelt condolences to you for your loss. Spend time with those who are close to you and remember him, what he stood for, his impact on you and what you can do to better yourself. I know it must be very hard now but just know that in time, it will pass. Life will move on and it is our responsibility to remember those lost and live our lives the best we can. Surround yourself with your loved ones in tough times, that is probably the best advice I can give. Good luck on finals.
dealing with death is usually very difficult when you do not know how it sits with you, and how it sits with your world view (religion, faith, family, geography, and your expectations). i think that mourning is just a part of the process to find out what you really believe in, its a hard test that life throws our way. just know that you can pass it and look forward to what is next. i find comfort in knowing that death is just a part of life, like birth is too. i find comfort in knowing that God has a plan for all of us, and that everything is a part of that plan.
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My condolences. That must be very, very tough.

Many colleges have counseling services and I'd advise you to seek them out ASAP. They can help you. Among the least important of the things they can do is help you try and get some extensions on your finals so that you don't have to concentrate on some stupid book less than a week after this terrible shock.

If your college can't help I'd still advise you to see a counselor. As someone who is married to a counselor, I assure you that they have skills that I will never match, especially over the freaking Internet. I do love the web, but sometimes it really is a lousy substitute for a face-to-face conversation with a human being.

I will confine myself to this advice: Your finals are unimportant, and your "milestones" an order of magnitude less important than that. Your well-being is important. Give yourself permission to mourn. You need to do it -- everyone needs to do it -- and it's unreasonable to expect it to be possible to shunt it off to the side and focus on work. And, in general, the people around you will understand this. The world will not come to an end if you take some time for yourself.

[Composed before I read kyro's post, which is precisely on point.]
So, a long time ago, my best friend died. It was really hard. I didn't eat or talk much. I still go to his grave from time to time. It was a fundamental change in my life.

Take the time you need. A week of renting old movies or playing video games is a tiny tiny risk to both your degree and your startup.

I'm not sure what's best for you, but for me, i had to take time to figure out what it meant that my friend was never coming back. It's hard. Once I came to grips with that i thought a lot about what really matters.

If it was me, I'd not work on the startup, and just doing enough school to keep up for a day or three... Spend time thinking through exactly why I was in school, and why i'm doing a startup. But again, do what's best for you. Maybe work is just the thing to keep your mind off how tough something like this is.

Call your parents. Talking to my dad was a lot better than my mom.

If you feel like i think you feel, these words won't really mean any thing, but you have my deepest sympathy. It gets easier... but there are always tough days.
No amount of grieving is going to bring anyone back from the dead, so try to move on with your life.
Try a change of scenery, avoid doing things and places that remind you of your roommate. Try to study at a different location, maybe the library or a starbucks. Find a different place to sleep too, crash at friends maybe. Don't mourn or even think about what happened until you've hit your milestones. Thinking even a little will open a flood of emotions. Play a game or something (flash game / mine sweeper / super mario) whenever you need to take a break or when you lose focus, but don't let your brain go idle. Get more sleep deprived than usual, so your brain will be a bit less reflective and you will fall asleep quicker too. Oh, and try to completely avoid news sites and all that stuff.

At least, this is how I handled it when I didn't have time to mourn. Your milage may vary. My condolences and I hope you'll make it through this period.
The Way We Read - Mossberg interviews Bezos
Poor. Statistical. Controls.
instead of completely banning TC, what if we ban all TC articles that mention Twitter?
Breakfast is by far my favorite meal of the day. I always wake up extra hungry and can't wait to eat something. I usually eat toast with peanut butter and honey or jam, a bit of fruit, and whatever else looks tasty. I always have a hard time understanding how people don't eat breakfast because I wake up sooooo hungry. I'm totally worthless if I don't eat breakfast.
I watched a friend of mine slowly die of AIDS over a number of years. I was in the room at the Hospice when he actually died.

I drank to deal with it.

My wife's 18 year old brother died of a stroke in his sleep. He was an adopted kid who's biological mother was a cocaine addict.

She wrote a book about him.

I ended up with alcohol problems and she is close to getting a book deal. I'd say her approach was the superior one.
Your next data center (rethinking data center design)
Theory and reality for storing personal information
This is definitely a time to put everything on hold and think about life for a bit.

School, jobs, and startup can wait - talk to a dean about your finals, you can take them at the end of the summer. As far as jobs, write "Expected graduation: Summer 2008", on your resume and get a letter from your school explaining there are extraordinary circumstances that prevented you from taking your finals.

Spend time in places without distractions (mountain, park, beach?) and let your mind wander for awhile - think about life, about what your roommate's passing means in respect to your life. When you feel ready to get back, you'll be more focused than before.

Death of a close one is always a sobering experience - take some time to take it in fully before getting on with things.

All the best, practically and emotionally,
Andrey
Are High Profile CEOs Effective?
Presenting Overloadr: The Great Rails Host Shootout
I wasn't saying they were bad at/didn't have math, just that they didn't apply it to understanding the physical world.
What's Good for Apple Is Better for Everyone Else
You need to distinguish between Islam and the society that grew up with it.

Averroes may have been an Islamic scholar, but his true god was Aristotle. He was quite explicit in his belief that Aristotle's was the hight of human knowledge and that religion (meaning Islam) was a sort dumbing down meant purely for the masses. Averroes was a pretty crappy Muslim by today's standards. Avicenna had a similar viewpoint, though he was more orthodox.

That said, we do owe a lot to these thinkers.
Is 3G Ready For The iPhone Stress Test?
FTA:

“When I started I thought that this would take 6 to 12 months,” Mr. Harman said. What he found instead were companies that had little interest in redesigning their products, even in the face of the promise of double-digit increases in efficiency.

I've found that you need for something to be at least 10 times better before people will consider making the effort to think about using it.
I'd like to think of this as a chance to rebuild some of that industry that we've so happily shipped overseas over the past three our four decades. Competition will force American businesses to either innovate or die, and I'd like to think that there's some hope that we'll choose the former option.
Ask YC: Very large database scanning
I have a database with 10 million+ rows that needs to be scanned on several columns. For example, we need to select from the database where column A>10 and column B<5.34 and column A<100 and column C=3, etc... on 40 or so columns. All of the columns are int or float. We want it to be possible to select on these columns in any order and any values.

It is important that it be very fast. I care more about speed than I do about how much disk space it takes. I've tried indexing, partitioning - but I haven't come up with a solution that works quickly and in the way we want.

Could anyone offer any advice on the best way to go about this? Or advice on what I should read? Anything is greatly appreciated!
While nice, it often isn't that simple. I've been floored for quite some time now due to a similar set of circumstances, and even for normally resilient people, it can take a long time to bounce back.
You don't deal with death. It deals with you.

In a short span when I was younger, a friend killed himself, my great grandmother died at 99 years 11 months of age, an acquaintance died in a car accident, and an old friend's brother died in a freak golf accident from a brain aneurysm.

It's not an exaggeration to say it all changed my life permanently. My advice is to let it. Don't go stoic and pretend it is something that happens every day. There is a quote by Camus that gives you a sense of the solemnity and the terror of the thing: "Don't wait for the Last Judgment; it happens every day."

This one may not be for everyone, but John Donne wrote some words about death that I have found useful at these times.

"No man is an island, entire of itself; every man is a piece of the continent, a part of the main. If a clod be washed away by the sea, Europe is the less, as well as if a promontory were, as well as if a manor of thy friend's or of thine own were: any man's death diminishes me, because I am involved in mankind, and therefore never send to know for whom the bells tolls; it tolls for thee."

http://www.online-literature.com/donne/409/

Those words are not just about your friend... they're about you. Death is deeper than cells and physics. Be involved in mankind. Don't be an island. Lean on your friends and family.

And take time to process things. Life can wait.
May your friend rest in peace, and may you find some source of comfort and solace.

I wish I had some properly good advice, but I'm woefully behind on my project for a very similar reason.
Wow that site is sure accurate in its domain name.

http://www.crazyontap.com/topic.php?TopicId=37043&Posts=...
I've been taking Biotavia's Bioforte 250mg capsules:

http://www.biotivia.com/english/index.php
That's not to mention that it's not "obvious" to me that a mouse is a better way to control a computer. If I had to construct a "find" query using a point-and-click interface, I would be highly annoyed. I use keyboard macros on GMail so that I can do everything without touching the mouse, and I get really annoyed when the page loses focus and I have to click inside it to restore it.

So not only does acceptance take time and require good timing, but it may also be that something that is "obviously" better may just seem obviously better to you.
http://www.httrack.com/ - it won't let you spell check. For that, you'd need another app. Something about writing your own Python spelling app here: http://www.norvig.com/spell-correct.html - good luck.
"They'll grow up," says 1983 graduate David Epstein. "They'll have a broader worldview and they'll understand that there are many, many ways to contribute. You know what they say — the freshman bring so much, and the seniors take away so little."
What does twitter do ?
1) Keep your friends and relatives close to you
2) Amuse yourself - TV, Movies, books, chat, etc.
3) Exercise - Jogging, Basketball, etc.
4) Move on and accept that sometimes things happen...
I published my GNU Make book on lulu.com and I think the quality is perfectly good.

http://www.lulu.com/content/2584447
No amount of grieving is going to bring anyone back from the dead

That's not the purpose of grieving. Surely that's obvious? It seems to me its purpose is precisely to move on with one's life. Disconnecting from your feelings is not a very effective strategy in the long run.
Enough with these 0 content posts already!! They are ok on TC not here!
This is only true if you think your application can do a better job of scheduling than the underlying OS kernel. In many (if not most) cases, this is false.

Why is it false? As the other reply notes, you have more domain knowledge than the kernel's scheduler does. You also didn't need to pay the overhead of entering the kernel to context switch (which is why context switches between userspace threads are cheaper than between kernel threads). In the case of fork()-based servers, you also need to flush the TLB (depending on the CPU architecture).

I'd be curious to see links that support your last claim: AFAIK, it is fairly well-known that event-based daemons using epoll/kqueue are the most performant technique for writing scalable network servers. See C10K, etc.
PGP rolls out Whole Disk Encryption for Mac
wait, i thought that the background radiation is not actually completely even, and that in some areas there is up to 10% difference from the average.
In the last year, two very good friends of mine lost fathers to suicide. One friend chose to seek emotional shelter in his family and friends, and he let the necessary depression and mourning take over his life for about a year, while he was in a safe place.

The other became an alcoholic and a drug dealer.

Honor your friend and his memory, by putting him first now, so that later in life, you will know that you have made your peace.
Lyime,

I am really sorry for your loss. I had a similar experience. I worked at a spot a few years ago. I had one particular guy stick his neck out for me and help me a lot. We worked side by side and he would drive me home almost every day after work.

I would never forget. I was sick on Tuesday and he was very caring and asked me several time if I needed anything. The next morning I came to work and found he died. He collapsed at home and when they got him to the hospital they found he was at the final state of diabetes and he never knew it.

I was shocked and did not cry right away. I was extremely hurt and I felt better when I stop trying to be tough and cried when I wanted to.

Acceptance will help you. Think of the good moments you had and cry about it as well. It will be good.

I wish you the best and always remember "what does not kill, makes one stronger".
"Expect silence on our end if they do [succeed], and a merciless blog post if they fail."

PG: How about this: all stories from Techcrunch should be allowed to be downmodded.
It's a great read, although it hasn't been updated since 2006, so it should be read with care.
People fake and stage photos when they find it helps their 'cause,' hence the need to spot it when it happens. I am not advocating staging them. A Palestinian kid was killed in a staged shootout with Israel. Truth all the way.
You haven't provided enough information.

What is quickly? 10ms? 100ms? 1 second?

What is your database?

Suffice it to say, this isn't a hard problem. Why not stick all 100mm rows in memory?
Portable Spas and Hot Tubs - Spas N Stuff.
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I swear by the Starbucks Ham and Cheese breakfast sandwitch. They are really good, lots of protien, some fiber, little fat for 300some calories.

After a lot of trying out, that is the food that gives me energy keeps me less hungry until lunch.
Angel, VC, or Bootstrap?
Or obviously better in retrospect.

I'm with you on the keyboard. It's substantially easier to process large amounts of data with a UNIX pipeline or an SQL query than it is with many GUI tools. Many people don't realize that.