skysight-inc/HackerNews huggingface dataset:
Taken out of context, the press release makes this finding look a lot more ground-breaking than it is after I quickly read through the actual study. Still a good piece of work though.

It was already known, as pointed out in the actual paper, that Amyloid-beta (AB) and Tau, the proteins that have long been implicated in Alzheimer's disease (AD), have prion-like properties which means they exist in an abnormal 3D configuration that causes other AB/tau proteins they interact with to adopt this abnormal configuration.

But they can also polymerize into large neurofibrillary tangles (NFTs). Patients who died late, e.g. at age 80 with AD had a lot of these NFTs, so it seemed reasonable by many to assume that these NFTs are the major cause of brain deterioration. But there were a number of alternative hypotheses of what exactly AB and tau were doing in the disease.

This study suggests that AB and tau cause disease primarily through their prion-like activity and not due to their ability to accumulate into large trash-balls (NFTs). They noted that patients who died young of AD had very few NFTs but have a lot of the AB/tau prion-like forms, whereas patients who survived longer had a lot of NFTs but not a lot of prion activity. This lends evidence to the idea that the primary pathogenicity of AB/tau is through their prion activity and not the fact that they accumulate into large protein blobs.
Obligatory: http://languagelog.ldc.upenn.edu/myl/ScienceNewsCycle.gif
I've often asked myself this question - are there any fundamental reasons why language needs to be the most expressive way to instruct computers? If not, what else?

.. and I've tried to resist answering it and letting the question ferment instead.
I don't have enough information to either confirm, or deny that statement. Why do you think it is absurd?
I think you answered your question yourself: Create a habit. Just set 1 hour a day where you decide to write, comment (you already did it here with this post) and this will become easier to do it constantly. You just need to get started.
The only way to get a surprising-if-true result that is not surprising is if the result is not true. Hence the joke is that most of these surprising findings are probably B.S.
Anything here will be Anecdata at best, but I've bought 3 refurb t420 and t420s; these are 8 years old now and still daily drivers for all my family members. The t420s in particular is my all-time favourite laptop of last 20 years, as it's thin and portable, but still modular (t420 is significantly thicker and more old-school portable), easy to upgrade and maintain, and with great keyboard with standard layout.

I have also used regularly a t450 and t470 for work, and last year bought an anniversary t25 as a Xmas gift for myself :).

Prior to that, I've used T530, T410, T60p, T41, T30, etc.

My boss has been put on notice that a Thinkpad is a "condition of employment" for me - I cannot imagine using anything else.

All of them have been absolutely positively rock solid. No issues as daily drivers for a travelling consultant - lots of plugging and unplugging, moving, backpacks, etc.

Mostly various Windows versions, but T450 and T470 are RHEL full time, and I have a T61 with Lubuntu as well.

That being said, for any brand, there'll be people with good and bad luck/experience. You have to look at your preferences, and stats...
Create habits.
Not at all. Colonization used violence to take over people's land and enforce the incoming people's laws on the existing population. Peacefully buying it with no duress is a perfectly acceptable kind of colonization, but that's not the word we normally use. We call that "immigration", or in this case, internal migration.
How many legs does a horse have
1MB doesn’t support directories at the time of writing.. did your Hugo site make use of directories? Or another thing I can think of is if you’re trying to make a single page site make a 200.html file (it’ll replace index.html and all requests to nonexistent files will go to 200.html)
I own a T450s. Definitely no bloatware that persists through a reinstall (that was for a particular case with Lenovo's consumer lineup... completely unexcusable, but never touched ThinkPads), which I would recommend for any laptop regardless of the OS, especially if you're buying used. Doesn't matter if it runs MacOS (unless, of course, you implicitly trust Apple's supply chain to be 100% robust), Linux (which I don't think anyone except System76 or Dell actually sell out of the box), BSD (which I don't think anyone sells out of the box), or Windows (which has competent driver detection and management now, making most "system update tools" useless). Wipe it and restart.
For aircraft, fuel characteristics relative to airframe and payload also matters.

Liquid hydrocarbons store readily in wing tanks at temperatures from (roughly) -50C to 50C. Pasengers and cargo can be allocated to fuselage, arranged in a contiguous space for the length of the craft.

Pressurised hydrogen favours cylyndrical or spherical tanks, located near the fore-aft midpoint of the craft, effectively segmenting the (pressurised) fuselage in two; before-pressure-vessel and aft pressure-vessel . Cryogenic hydrogen would require Dewer vessels and venting with considerations for mitigating hydrogen explosion risk -- present over a wide range of concentrations.

And in both cases, metal embrittlement and molecular leakage occur.

Adding a few carbon chains mitigates all these factors.
Clojure: HTML to Markdown
Is this related to Dell Computers (so it does include laptops with Linux OS) or Windows OS (which I mean spywares on Windows OS)?
It is worth noting that Teslas don't update "any day for any reason". The updates are very rarely more frequent than once every several weeks and have to be manually triggered and approved by the owner.
Related: https://www.google.com/search?q=how+many+legs+does+a+snake+h...
Thank you! I really hope you find 1MB useful :)
AI Dungeon
I have no idea what the mechanisms affecting protein folding are in this context, but if you are interested in learning more about how proteins fold and perhaps helping researchers fold interesting new ones, check out FoldIt (a protein folding citizen science project): https://fold.it/portal/

It was featured in Werner Herzog's Lo and Behold and I had the privilege of taking a class taught by a professor involved in its development. The community there can do a little bit to restore your faith in humanity and technology.
> Have you purchased a Lenovo lately? I've not had good luck with them.

Same. My Thinkpad 25 has already been back twice. And both their field service and their factory service have really gone downhill.

As much as I love the keyboard, this may be my last Thinkpad.
Academia.edu | Full Stack Engineers; Product Managers; Data Scientists | San Francisco, CA | Onsite

Academia.edu is a distribution and peer review platform for academic research. The Academia.edu platform addresses two problems:

- Open access. The goal here is to put every academic paper ever written on the internet, available for free.

- Robustness. The goal here is to produce a set of signals around any given academic paper that indicate how robust the paper’s claims and findings are.

It has emerged over the last few years that 65-90% of the academic literature is not reproducible. What this means is that if you try to reproduce the experiments described in a paper, 65-90% of the time you will not get the same findings. This is known as "the reproducibility crisis”. Peer review is not a robustness filter; we need a separate filter to indicate robustness.

With regard to open access, Academia allows academics to upload papers to Academia, and make them freely available. Academics have uploaded about 20 million pdfs to Academia.edu. About 60 million people come to Academia each month to access and share papers.

With regard to robustness, we think the way to build a robustness layer on top of papers is a) to mine the existing graph of citations for commentary and (b) crowd-source commentary/peer review from the academic community.

Academia has built a recommendation system which is the basis of our approach to (b), and a citation graph infrastructure that is the basis of our approach to (a). We believe that addressing robustness is a challenge and an opportunity. We need mission-driven engineers to come and help us.

We have raised $33 million from Tencent, Khosla Ventures, Spark Capital, and True Ventures. The company has a freemium business model. Bijan Sabet from Spark Capital writes "We believe open science is really important. We believe Academia.edu is going to have a profound impact on the world."

We are looking to hire full stack software engineers, product managers, and data scientists. Technologies we use include Ruby, Rails, Postgres, DynamoDB, React. Our office is in downtown San Francisco. For more information, visit http://academia.edu/hiring.
Just 50 states would be easy. You're forgetting county and municipal/locality taxes. Or the varying due dates for each of those jurisdictions. Or whether or not your widget business creates a nexus in those states and requires you to register as a foreign entity. Or whether or not your specific widgets trigger a higher or lower taxation rate. Or that whether or not shipping should be taxed also varies state to state. Or...

It's a whole lot of work to be legally compliant.
If renting and owning cost similar amounts over time, then how does anyone afford to own rental properties?
Yeah, PKI would work in that case too.
Bring your friend into the thread!
"the strength of the return packet is generally directly proportional to depth (algorithmically"

Err, no it isn't. You send a tx pulse and correlate it with a rx pulse and use the time of flight and the wave speed to get a range. You need precise information about where the tx pulse was sent to turn the range into 3d point relative to the sensor. The correlation and orientation steps are algorithmic and fundamenally statistical. For ultrasound and radar you can put a code in the pulse to make matching them up easier (the pulse lengths are typically bigger than the resolution you require). All algorithms. All can and do go wrong.

Old school stereo matching looks at cross correlation (or cross entropy) of image patches. If the cameras are orthorectified (translated with no rotation) then you just scan across the row of pixels to find the patch with the best match and how far across it is is proportional to the depth. Feature correspondence (with sift like features, very low level) might be used for getting relative rotation and translation info between the cameras for calibration and as a depth prior. People are doing the same sort of thing with NNs to get the depth map.
Thank you! Hope you find 1MB useful :)
I'm convinced renting is the best thing for old age.

The reason I say that is because 9 times out of 10, from what I observed, old people who own end up living in squalor because they lose the ability (financial or otherwise) to care for their house. Maintenance ends up being deferred indefinitely. At the same time senior apartments are incredibly affordable, at least in my area.

Sure, that's not every old person, but I see it enough that it's concerning.

P+I is just a part of the cost of owning a home.
In the timeframe the events this article take place on, the EU was insisting on a "browser choice" screen to be included in Windows 7. MS also got criticism for the random shuffle they used to determine the order of browser icons.
Given that we're talking about a store, a shopping cart is generally a good feature. Wish lists / favorites are a useful QoL feature as well. There's a bunch of things like that where it's hard to believe the Epic games store is being pushed so hard without them.
> If I donate to a nonprofit, itemize my deductions, and get a tax reduction based on my donation, am I not "evading" taxes?

No. You're mixing up terms. That's avoiding taxes. There's a critical distinction in the tax world between avoiding taxes and evading taxes. One is legal and common, one can send you to prison and get you a lifetime of close IRS scrutiny.

Simplified, evading means to not pay what you actually owe (what you should be paying). Avoiding means to use entirely legal means - such as deductions - to not owe the taxes in the first place. To evade taxes you always have to do something illegal. In avoiding taxes you should never break the law.
Addressing your second question.
Informally, dropping nodes fights overfitting by creating subsample architectures of which are essentially thinned out networks of the one you've designed. Having trained on these sub nets means you've effectively combined the learning of a few different models and in doing so have generalized beyond the capabilities of your original "single" architecture.
Hipaa: Privacy and Cloud Security
If it's not affordable, how is it a good investment then? Going into crazy debts is not a good thing.
North Americans are the biggest bullshitters
There are these mom and pop shops, they make a pasta a dish, or biscuits, or whatever. They are cheap yet tasty, and popular. Obviously the margins are thin, but the owners don't have huge ambitions, aren't trying to expand, get a new big house, etc, they just make food and by doing so make a living and provide for their family...and the people respond. These mom and pop stores become the fixtures of the community. They server the community. Those are the best places.
When corrected for inflation equals zero. And 1990 was 29 years ago.
Well if you donate money it should, in a perfect world, be only tax deductible if it is for an effort society seems of special value so that incentives are implemented to support this.

So tax deductible donations show what is important for a society at large. And society profits.

Leaving a country to evade taxes doesn't help society at large. People do this after they profit of the infrastructure and all other stuff society provided and paid for with taxes.
Tesla should get taken to the cleaners for this, I hate that these cars w/"autopilot" are operated on the same streets I use.

They should focus on making quality, well-performing electric cars. Stop using us all as beta testers for an autonomous future most of us never asked for.
How to Calm a Crying Baby Like a Mesopotamian
Stealing? That would imply that someone else's money belongs to you, which by definition it does not. I think it's unethical to tax anyone's income, and if people can escape it I'm happy for them.
It’s always been like that, hasn’t it? I seem to recall it being one of the reasons why liberalism has had such staying power.

It was how the Dutch became a powerhouse on the line of Spain, England and France in the colonial age. Because they let their people be, and didn’t take their wealth, it became an attractive haven for rich families who then did business.

I’m not sure the latter is as beneficial as it was then, as you can now turn money into more money without investing in local business, but the former is going to remain true forever. People who have the means to do so, will always chose the freer country.
Looks to be a list of _Web_ UI libraries. Some mobile platform stuff sprinkled in. If Web-only isn't the intent, then the list is sorely missing Qt (https://www.qt.io/).
“Gay is a part of who you are, whereas voicing particular political views is a choice.”

Can you prove either one of those statements?
They did unencrypt the assets and save files, so maybe some modders will add new levels?
Link to study:

http://ftp.iza.org/dp12282.pdf

Economist summary:

A new study of the phenomenon has found that North America is especially prone to speaking bull. John Jerrim, Phil Parker and Nikki Shure, three academics, have used an educational survey of 40,000 teenage students in nine English-speaking countries to find out who is most likely to spout nonsense. They inserted a section into the questionnaire which asked students how well they understood a collection of 16 mathematical concepts. Some were familiar, such as “polygon” and “probability”, but three were fake: “proper number”, “subjunctive scaling” and “declarative fraction”.

The results show substantial differences between countries. Canadian and American teenagers were especially likely to profess knowledge of these bogus topics, whereas the Scots and Irish were perfectly happy to admit their ignorance. In news that will shock nobody, in every country men claimed to be experts more often than women. The rich were more boastful than the poor. More surprising was the finding that immigrants were generally more likely to bluff about maths than native students were.

What explains these differences? The academics doubt that the bullshitters were simply trying to impress the questionnaire’s markers. The students who bluffed about maths were just as likely as the non-bluffers to admit that they had skipped school recently, for example. A more likely answer is that the blaggers over-estimated their own knowledge. They also tended to rate themselves highly when it came to gauging their own popularity, perseverance on academic tasks and problem-solving ability. The data suggest that they might not be consciously lying, but instead be weaving their own fantasies.
Thanks for the links. Their "Vehicle Safety Report" is literally 3 sentences! I expected such a report to have much more detailed information in it.
"donate to a nonprofit" is not 'tax evasion' (which is illegal)

You could argue it's tax avoidance, but it's not even that, it's just making a donation, and that's how they are taxed. It's part of your normal activity: taxes are higher on some things than others.

Creating a non-profit as a special purpose vehicle would be 'tax avoidance' but if it's legal, it's legal.

The OP's comments are perfectly just i.e. punishing tax havens because there's deep incentive for them to facilitate actual tax evasion, moreover, they enable the stockpiling of surpluses generated elsewhere. Especially for those part of a 'common market' - you can't have taxes at 1% in Malta and 50% and France, it's not going to work.

Dubai does not have any tax deals with the US, it's built on utterly shady tax dealings. Much of the money poured into Afghanistan by the US for reconstruction ends up there, for example. It's super duper dirty.

People are not fleeing China because of 'taxation' in the classical sense, they're fleeing for a pile of other, obvious reasons.

People are however fleeing France, partly due to 'taxation' and this is an issue ... they have some issues with competitively and their solution of 'just tax the rich' will not work out if that's it.

Worth considering: normalize the migration data against 'regular people' and what you'll find is that still a lot of Chinese are moving to Australia/Canada, and in general people are moving there, the US anyhow!

I'll bet the one that sticks out a little is France. I don't suggest a ton of people are leaving, net.
What's funny is we actually used YouTube as our "gauge" on what browsers to support. We also built the narrative that: "If YouTube doesn't work on this browser, then we will not support it"
“Protected class” is a distinction that is one “human rights committee” decision away from changing
For folks interested in future programming tools — be it languages, editors, IDEs, visual programming, new abstractions, what have you — I recommend looking at the https://futureofcoding.org community. The podcast has a number of great interviews with people exploring all corners of this problem space, and the Slack group is full of people actively working on these hypothetical-future tools and sharing their findings.
It means compiler caches results of module compilation and reloads them if module didn't change.
Hot code reloading is not supported.
I don't know how they didn't all get fired. Like, ALL of em, including everyone who set up the special "OldTuber" priv long before.

Because this is how everything on the web used to be done. Google won the internet partly because they moved away from this first and best, but product decision making by engineering and overriding approval processes in the name of a good outcome were pretty much standard back then.
I'm not comfortable with this. why should we need to avoid code reviews, sacrifice readibility and bypass tests to make up for poor business decision making?
We need a similar article for what the average class is doing when it comes to migration.
Numerous website highlights similar things in text :)

And considering blueprints spit out C++ once compiled, I'd take my chance with BP!
People holding on to more of their OWN money is some how stealing "from the rest of us"?
iOS doesn't support WebM. Why an OS should dictate what videos you can play is beyond me, but that's the wonderful world we live in.
"I think it's unethical to tax anyone's income"

Wow, more classically liberal than the man himself Adam Smith, who basically invented the concept of graduated taxation because he laid out how such systems would work and what would end up happening without it.
> I don't have any obsession with distros. I want one that works.

This is why I became a Mac user. After 15 years of Linux I was just done with all the bullshit, but I guess I could look into Pop!_OS.
Unfortunately, it's hard to find a way to allocate land without using the market. Yes it's unfair that rich people have to pay more to live where they want than poor people who are happy living near other poor people, but how else can you allocate land that gives the useful land to the people who'll get the most value from it? Central planning doesn't get it right, a lottery would mean people can't group themselves together so they would lose that important value (eg programmers in Silicon Valley).

Land value tax would take money from people who don't need those community services and give it to different people who happen to live nearby. That's not really fair. It's still a kind of rent seeking that also happens to give the rent to charity but not back to the original payers in proportion to what they paid. But it does sound more reasonable than the luck of the draw that property owners get.
99942 Apophis
In the 80s at FORTH, Inc. we had 'shadow blocks'. Forth code would go in one block and comments in the corresponding shadow block, and you'd flip back and forth with a keystroke. (We only had 80x25 text mode for coding, iirc. Your graphics would've been out of reach.)

I don't remember how or if people kept the shadow comments lined up with code (I was only there for one summer in high school), but you could extend the editor with ease, so...
His account was made in 2011, which makes me think maybe (hopefully?) he meant 'I would have guessed' and not 'been' 4 or 5 years.

Either that, or at 15 he is way more involved in software than I am now :P
Interview with Rahma Javed, Director of Engineering at Deliveroo [video]
>I remember when it was accepted scientific consensus that plate tectonics was a crock of shit. Didn't make it any less true.

No one is saying science is infallible. It's just the best explanation for what we're seeing so far, based on empirical evidence. Your argument that science was wrong about something in the past does absolutely nothing to support any of your claims - for that you need to post evidence.

>If the data shows that the Arctic is doing fine, then I don't care how many climate alarmists say it's melting if it isn't.

Your own link you posted contradicts this. I'm starting to think that you don't understand the contents of your own link, because it very clearly contradicts what you are trying to say.

>Tony Heller destroys the fundamental deception of global warming here: https://www.youtube.com/watch?v=8RwjYkYCXnU

This is a typical tactic used by climate change deniers. Ask for evidence - when they can't provide any, they distract and post something completely different and try to deflect.

I'll spend 10 minutes of my time watching that video after you spend a little effort and post a scientific paper that supports your original claim.