skysight-inc/HackerNews huggingface dataset:
My guess is that it would be difficult because you have to kill off/weaken the existing problematic cells to allow the new ones to take over with these therapies.

This is manageable when you’re treating a white blood cell disease as you can live temporarily without these cells and they regenerate frequently.

But if all you need are some cells to produce more of an enzyme and can produce it in sufficient amounts to manage the existing cells producing the bad enzyme, you might be in luck.
can't see anywhere mentioned geofencing.
So delegate this all to a few large blacklists (spamhaus)? And block all residential users by default?
In fact, a measles infection can ruin one's existing immunity to certain other diseases,ceven if previously immunized.
I suppose there's something strange with sport at all. Her story isn't unique, just look here: https://en.wikipedia.org/wiki/Verona_van_de_Leur

Amount of people in sports are much lower than in army, that's why we may not hear their stories, but it remembers me a problem with veterans. The same issue - it's hard for people people to adapt for a new life without extreme load. I really don't know the right answer. Teach them since start life is not only fighting, cycling, trainings ? there're something else external life ? But it's hard when your couch pushes you to your limits& I don't know.
OP is not saying they cannot monetise their product as they see fit (it's their product). No one is saying that.

But when you have been offering something for free for years, people get used to that being the way of things, users are not going to respond well to the increase in advertisement.

Had Google done this from the beginning, people would have been more accepting of it. Generally speaking, if you change a service for the worse, people are generally going to view it less favourably than had it started out how it will now become.
If you only have a few "type" options, that may be a poorly performing index unless it's used as a secondary to a query that narrows results more.
Here we have some of the brightest and most privacy-aware people in the world trying to come up with ways to convince family and friends that privacy is important. And still, I can't see a single compelling argument that would actually work or even make my friends and family think twice about it.
You can get a Pilot Varsity or a Platinum Preppy for just a couple bucks, and they write pretty dang good. It's a great entry point in to fountain pens.

Having nice pens makes me want to use them more, and writing more has helped me organize my thoughts better, especially when writing code. I'd highly recommend it to everyone.
Passport. Credit Card. All you really need.
Laziness perhaps, but consider incompetence as another possibility. Many journalists seem to have only the sketchiest command of English.
Apple maps is inferior to Google in almost every respect in Asia. I open it now and again just to see if it’s improved and always switch back immediately to Gmaps. With hardware sales slowing Apple has a lot more incentive to improve it than they did when the iPhone gravy train seemed unstoppable though.
Many classical full information board game at PlayOK[1] and free, but not so many players.

I believe there are more board game sites where you can find people to play with, like board game garena[2].

[1] https://www.playok.com/
[2] https://boardgamearena.com/
Although it may be a first for this specific SCID (X-linked), there are other SCID forms that have successfully been using this gene therapy approach for a little while.
I really don't know why inefficiency is ok, sorry. If a system is less efficient at scale then engineering approach teaches us to modularize/split it into smaller chunks.

Btw, you used "professional" word as if it's something good in itself. That's far from truth. Professional bureaucrats, and state officials quite often are directly interested in growing inefficiency because it can be exploited to expand budgets, and staff.
Ubuntu 19.04 has been just released
Give the F-Droid store a look: https://f-droid.org/
> That and the fact Japanese population is shrinking so there will be less demand for it, I'm wondering the real estate value will continue to raise like it currently is.

Japan's population is shrinking as a whole but still growing in cities (especially Tokyo). You can already get a house in the countryside for free : https://inakanoseikatsu.com/category/不動産物件/無償譲渡（0円）の空き家物件/
> X-linked severe combined immunodeficiency, or SCID

This is poor phrasing. There are non X-linked SCIDs.
https://www.reddit.com/r/miband/comments/8eqtve/comment/dxxj...
Actually it's 100 yen at Daiso in Japan, with very few exceptions.
>> stop words

It's a good thing neither Bing nor Google remove so called stop words, because if they did I wouldn't be able to google them for the lyrics from that great song by "The the".

If you use a system that require you to remove stop words from your lexicon I suggest you find better tech because removing them destroys linguistic context. If you're using a search engine that doesn't care about linguistic context, again, you should find better tech.

Even the most naive search engine should at least be using tf-idf or some other statistical tool to determine both a token's document frequency as well as its lexical frequency. That's very important context to have.

If you insist on using stop words most tokenizers would assume you did the filtering or they'd want you to submit a word list for it to use as filter. Be aware, you are not making tokenization much simpler, because a proper search engine stores each distinct token once and only once in its index, so you hardly saved any space. What you did was to slow down the indexing process and use lots more CPU cycles for each token which translates to energy waste in my mind.

Leave your stop words right where they are, and save the planet.
Maybe just don't be a pervert?

If my search history were leaked I'd still go about my life happily.
Defying Expectations: Final Fantasy VII's Victory Fanfare
There are quite a few professors I've run into at Seattle Central and North Seattle College that have formerly taught at UW Seattle, but left due to situations like what you describe (dept is fully supportive of X happening, but due to an age old rule it will never happen).

UW has a ton of baggage and is quite inflexible compared to other institutions in the region and state, their lack of flexibility is enabled by having the highest tuition in the area ($11k vs $4k per year) and significantly higher state subsidies (UW, WSU, etc taking 60% of the state's college budget, yet only educating 40% of the students) than 2 year institutions.

This underfunding of 2 year institutions in favor of UW and ilk was what triggered the walkout yesterday and the ongoing protests: http://www.thestand.org/2019/04/join-aft-members-april-16-wa...
The problem is not lost context. The problem is that adding an item to a checklist protects you from a category of outcomes. If you have a checklist item to make sure a release is signed, you will never push an unsigned release.

Removing an item from a checklist is done in response to a change in inputs. Sure, you may have automated release signing - but unless you are 100% confident that you are aware, and have mitigated 100% of the ways in which this can fail, you cannot, and should not remove the 'check that the release is signed' step.

Lost context has nothing to do with this. Unless you are an omniscient god, you probably cannot reason, with 100% certainty, that you have mitigated every possible input that produced a bad output.

So, check your outputs.
Check tinfoil for Facebook and Twitter then!
It’s a pretty flexible game system. A good GM would allow it I think, but with a high difficulty rating for hacking it.
Went to school in 90s, we used the Chinese version of Parker 51 exclusively, it was too big and tiresome for me. Nowaday, I use and like the Lamy safari pen much more, because it fits and is so convenient to holding and writing.
> Before the changes, Owczarek’s startup got 750,000 free map views a month and then was charged 50 cents for every 1,000 views on top of that. Then Google started charging after 30,000 views and the cost was $7 per 1,000 views. His costs jumped from nothing to $5,000 a month.

Ouch. How could that possibly be worth it? Are they just trying to squeeze money out of businesses that are already locked into the Maps API? It seems hard to believe that your average startup that needs a map widget (like, for food or pharmacy delivery) would go with Maps instead of OpenStreetMap at that price level.
That also applies to the comment I replied to.
Are there any implications regarding treatment of prion diseases like CJD, CWD, etc.?
What changed over the last 10 years, and why wasn’t it monetized earlier? Maybe because then they wanted to make a useful service and get some data for their search ads, and now they just want more money.
> I don't think the politicians are going to do much of consequence until their constituents think it is important.

My fear is that most politicians don't often seem to do much about any given issue even what their constituents do think it is important. I would guess that when there isn't much campaign financing/donor money behind any particular issue, even if it has popular support, then most politicians feel relatively safe ignoring it.

Certainly some politicians care about average voters' issues. A long time ago, I worked for one who did. But most seem like they don't. Most seem like they care mainly about their own pet issues, or merely getting re-elected as many times as they can.

Or I am just getting more cynical as I get older. I guess that could be as well.
> Bitcoin has a $12 billion volume in just the last 24 hours.

According to whose numbers?

https://www.wsj.com/articles/most-bitcoin-trading-faked-by-u...
I'm not from Greece and I can type any character I need to. It's just a matter of thinking very hard about it, and then the character "pops".
Ah, the old “I have nothing to hide” argument.
Reversing a binary tree is supposed to be an easy warmup question, not the meat of an interview. With a b-tree, you add some fluff to the problem.
I had a 51 many years ago. Much as I liked mine, it never occurred to me that people would write articles about them.

I've always preferred writing with a fountain pen, but can't see myself having one again (or at least a good one). I have the same problem with them as I do with sunglasses: they always get lost or broken.
Some people have problem falling asleep. Drinking until they pass out is a solution of sorts.
What was a standout result of her research in VR? What was the important question that she posed? Did she come to an answer?

I read through some of the posts on elevr, and I wasn't able to find something that jumped out at me, like Bret Victor's talks and posts did for me. Did anyone else?
That’s a good idea
Oh, I agree. But most Americans actively vote against that system.

As for those uninsured that just broke their ____ and are not in a position to start calling around, having pre-negotiated rates for the best pricing against all hospitals within a reasonable time’s transport would save a pile of cash. There’s no shortage of hospitals or excess capacity in the US.
Great. I stopped using Google Maps the moment I bought my IPhone. Unfortunately, it seems I'm in the minority when I say I get a better experience with Apple Maps. Apple Maps with carplay for the past year have been miles ahead of Google maps with Android Auto on all accounts for my trips. I was skeptical at first but I was never rerouted on weird residential neighborhoods / state highways or switch 3 freeways to shave off a minute of my trip, very accurate estimating traffic and transit time, etc... Keep in mind, I was also a huge fan of the Zune.
FabGL Has Everything You Need to Write Games for the ESP32
Uh, congrats, I guess...
The experiment is great hands on math but I would have enjoyed a discussion of variance versus expected value and the difference between short and long term averages... it’s too easy to infer that everything is great because he was lucky enough to get within the target range but the likelihood of that occurring is not actually that high and was only implied by the shape of the Monte Carlo distribution in his previous post. When such experimental results are this conveniently “accurate”, amateurs in the audience may take away the kinds of wrong inferences which create “it’s a hot day so must be global warming” type of logical inaccuracies.
I think that period was part of their investment and also helped them to improve the product. And like any other investment, they need to make money as well. I can imagine Maps is an expensive product to operate. I also hate ads and I hope they find a different way to make it reasonably profitable.
I don't think that's why the CDC suppressing the names of hospitals with infections.
If you don't have internal IT folks and an incident response team already in place you're going to need to bring in some outside assistance.

- Take all compromised or infected systems offline immediately and have them carefully examined to determine what data those systems contained (customer, internal, and employee) and what was exposed to attackers.

- look for additional signs of compromise in other systems as well paying close attention to those connected with the ones that were compromised

- log and record everything extensively throughout the process

- consult with your lawyers to see what legal obligations you have to disclose the breach publicly

- notify everyone directly impacted by the breach as soon as you've identified them so they can start taking steps to protect themselves. Don't wait until you have all the details, you can update them as more information is discovered.

- Make sure you have professionals to perform the investigation and re-secure your impacted systems before they are put back online. This isn't the time to count on that one guy in the office who "knows computers real good" to fix it.

- continue to keep extensive logs and keep a close eye on everything for a time after the attack to make sure you're not compromised again.

If you can manage even that much you're doing better than most of the companies I've seen who were hacked. I've seen banks leave compromised systems connected to the network for months after being notified. I've seen some pretty large companies refuse to bring in outside help because they don't want the expense even after they get hacked over and over. Many small to midsize companies try to handle everything as quietly as possible and never tell anyone what happened.
Nice HUD, I really like it! With the sign detection, does it save signs or feed them back to be added to the OSM base layer perchance?

Also, for parking pricing & zoning are you scraping cities maps for this? Eg: http://web6.seattle.gov/SDOT/SeattleParkingMap/seattleparkin...

My only annoyance was is your website seems to depend on ajax from Google and Google Analytics btw.
That article is not at all well-reasoned. There's a core of truth, which is that even with 100% vaccination a population may not always have effective herd immunity from measles, because the vaccine is not 100% effective over all timespans, and the threshold of immunity required for effective herd immunity against something as insanely infectious as measles is quite high.

But the author goes far beyond that conclusion and rails against the very idea of herd immunity, and claims that since herd immunity may not be possible in practice when dealing with measles, there should be no stigma against opting out of vaccination. These conclusions are very weakly argued, and the obvious counter-arguments are not addressed.
To consider the versions of Chinese apps uploaded to Play is already much cleaner and toned-down than their China versions.

DU Group is an affiliate of Baidu, which has been using ads like "Click a button to boost your signal 5X stronger" to harvest users. It's common and unfettered in China, since they are all watchdogs of the party.
For C:

Any OS

package manager => compilers, autotools, joe, dev libs, git, ...

emacs (with my .emacs since 1985)

lsp-mode with clangd, magit
It's not free and installed by default on every android devices ?

You mean, I can buy a subscription and not rent the service with my search history ?

Where's the sign-up button ?
Forget the contacts. People willingly gave Facebook their email passwords. Did Facebook also accidentally upload users' emails? Why would Yandex (from the screenshot) even permit this?
None of those diseases come at all close to being as easy to transmit as measles. The diseases you list pose little to no risk of transmission in an ordinary office setting.
Facebook Groups for Acquisition
Hi all,
Delete if not appropriate in this forum.
If you are looking to use FB groups as a new customer acquisition channel for your startup this might be for you.
Over the last 4 years we have built 4 fb groups with hundreds of thousands of active users.
Right now we have 1-2 too many that we can no longer manage effectively and are looking for someone who might want to take over ownership and continue to grow them, manage them and allow people to connect through the groups.

One of the groups has 167,000+ members with 112,000+ active
This group is centered around job posts and advertising job postings.
Another has ~68,000 members with ~32,000 active.
This group is centered around online jobs, virtual job postings and online opportunities.

We are looking to sell these groups to someone whose startup or company might benefit from running these groups as well as someone who will moderate and continue to grow the group.
If you are interested, shoot me a message mike@calltend.com
A Message from the Future with Alexandria Ocasio-Cortez [video]
THREE hours? What the heck do you do for that nearly 20% of your waking life?

I guess you buy a lot of books, or visit the library a lot. I personally like reading but not so much that I want to do it for three hours every flipping night.
> Ad fraud is simply the norm in China

Why is that? I can't even imagine what's going on at the meetings leading up to implementing ad fraud in what I presume is a normal company otherwise and not a bunch of gangsters. Is it morally OK to do this in China for some reason?
> compared to PC

How is Steam or Windows Store any different? How do you install apps/games on PC?
It requires massive amount of computing power, otherwise theoretically you should be able to explore different optimizations automatically. Even then, validation is still hard and time consuming though.
>> * Used pekoe tea bags, many.

Sure I drink tea, if someone asks me I'm not going to lie about that.
Could you please explain what kind of manipulation your library supports on finite state machines?

Does it contain a regex engine to easily create the state machines in the first place?

Does it have a JIT?

Do the state machines operate on char? wchar_t?

These are the kinds of details that I would love to see on the github entry page. It's obvious to you what your library does, but I have no idea :-)
Do users love it, or even notice it? I haven’t seen any data either way.

I’m not implying such data don’t exist; as I’m not deep in SEO or anything like that I would t be exposed to it. Any pointers?
Algorithmic trading in less than 100 lines of Python code
I'd be delighted to! We're using Electron, React and TypeScript. You can check out our development team's blog here for more information:
- Cross-Platform Application Design with Electron, React, and gRPC (https://medium.com/p/c13a429b5346/)
- Why Did We Choose React and TypeScript for QueryPie? (https://medium.com/p/56c9b2ab352)
It isn't free. They're already monetizing your location data.
What is a quantum computer? https://outline.com/9SVe9h
What a strange comment.

I was only making a prediction about what I think they will do. I'm not particularly cross about it, I think this kind of behaviour is inevitable.

I hope I have assuaged your concerns.
the ICT sector in particular pulls in people worldwide and has a high flight ratio compared to the normal population, domestic and international. so inside the tech bubble in California, I expect more people interact with people outside their core community, than other places. Compared to Omaha or Austin. Compared to Chicago? maybe not.

but I did mean in-the-wide too; i think since we started down the vaccines as herd immunity game in the 50s and 60s we now have more routine travel and the rate of change here has accellerated. When I was a kid in the 60s few flew, my first flight was at 16 and then no more until 24. Now, I fly 10+ times a year worldwide. Thats only 40 years gap.
Has anyone ever gone to jail for this? Oh, you committed massive fraud and stole millions of dollars? We’re just going to tell you not to do that anymore... in what world would they NOT incessantly scam the system with these completely asymmetric incentives?
What is lean C++?
Trust is an emotion, I won't rationalize it for you. You can distract yourself and others with math and rules and sturdy construction, but there's always sidechannels.
Based on my analysis the published image is too processed to be able to invert the colormap to get to the brightness temperature data. I had better luck with Paper IV Fig. 15. See: https://physics.stackexchange.com/questions/472641/what-woul...
You have nothing better to do do you?
And the app has become absolutely atrocious performance-wise. It used to load nearly immediately, but starting ~1.5 years ago I began noticing extreme slowdowns. Now it's barely functional for me. Every part of the UI is appallingly unresponsive -- taps that take 5 seconds to register, hitches in animation, etc. From tapping on the icon to being able to get underway (including typing in an address) used to be about five seconds or less. Now it's upwards of thirty.

This coming change to their monetization (really? mining our location data isn't enough?) is just going to be the final impetus I need to find some other solution.
How do you solve a shop being crowded (= successful basically) ?

The uncomfortable and usually unsafe part is something that could be worked on, but otherwise it has tremendous value for single purpose products or appliance where required quality level is extremely low (e.g. takoyaki sets).

It straightly goes against the romantic “buy it for life” idea, but I think asking people to care about every single stuff they buy is a tall order anyway.
Of course. The problem with Samsung is that they don't seem to care about proper execution, they care about being able to print fantastic features on the abck of the box, regardless of how well they actually work.
First they ask for email passwords. Then the new users assume Facebook won't comprehensively mine their emails. Then Facebook awkwardly gets caught uploading 1.5 million users' email contacts.

It doesn't make sense for people to trust the service at all unless you assume one of two things:

1 - Despite all the outrage on hackernews, and the NWT stories, our neighbours down the street and family members still don't know how Facebook works or what is done with their data

2 - They don't care about their data privacy. I've heard this claim many times, but the people saying it often change their minds when they read more news stories. I really do think people have trouble assuming the worst about the intentions of others and are inclined to be trusting.

edit: clarification
In the county, a few miles from the little rock city border (but still with a little rock address), my brother didn't have any internet access except satellite until last year.
“You hold it wrong”. Affected less than 1% of the users. Called “Antennagate”. Still remembered 10 years later.

Samsung: phone breaks two days after use. Kudos to them, bravo.

See?

IIRC Samsung also had its own antennagate, nobody batted an eye.
I would love to know what other choices HN recommends as well.

I'm at the stage of choosing such a service as well.

I would add woocommerce to that list.