skysight-inc/HackerNews huggingface dataset:
I'm sure the book is better, but the soundbite on what's called evergreening is very misleading:

> RF: Yes, 78 percent of the drugs associated with new patents are not new drugs. They are existing ones. Instead of innovation, we are seeing secondary protections piled onto old drugs over and over again. They make minor medical modifications by adjusting the dosage or the delivery system.

The patent system does not allow you to "extend" the protection of an existing invention by making minor changes. Once a product is released into the marketplace, the product itself becomes prior art. You can make improvements to the product, and patent those changes, but the original product is now in the public domain.

So evergreening can't work as a unilateral action from the drug company. It also has to be the case that doctors must be unwilling to prescribe a generic that doesn't have those improvements. And here is where the article buries a lot of complexity in a hand-waving dismissal:

> Here’s the most important point: When a drug company makes a secondary change to a drug, the R&D investment is minimal compared with what’s required for the drug’s initial development. Also, the change may mean little from a therapeutic standpoint.

As a threshold matter, no scientist or engineer (note the author is neither, she is a lawyer) would say that incremental improvements don't count as "innovation." And incremental improvement, though cheaper than building a brand-new drug, is not cheap, just like developing each new iteration of iPhone is not cheap. So what's really doing all the work here is the assertion that a "change may mean little from a therapeutic standpoint."

If the change doesn't actually result in a therapeutic benefit, then doctors shouldn't prescribe the new drug over the generic. For various reasons, doctors have little incentive to do that. The main thing is that neither the doctor nor the patient are paying for the drug. When you're not paying, you have no incentive to prescribe the "older model."

Insulin is a good example of this. The first biosynthetic insulin was released in 1982. It is long out of patent. If you wanted to release that exact same product today, you could. But the newer iterations are at least a little bit better, and who wants to give their kid with Type-1 diabetes anything but the latest and greatest version?
"Government intervention in market produces opposite of intended effect. Experts baffled."

Economists not surprised.
You assume that the ROI of oil will be more in the future. If Australia weren't a top materials producer the entire country would be poorer -now-. That oil money doesn't just evaporate, it reverberates through the entire economy and goes into other goods and services, which also grow. That economic growth will be better for the country, tenfold (and that's playing down the impact,) than just sitting on the oil and waiting for the price to go up...which it may never, due to dwindling demand and alternatives becoming cheaper.
> Under theoretical models of market economics, economic profit is the opposite of providing benefit to society.

It would be more accurate to say that the opportunity for profit indicates that society is not obtaining the maximum benefit from the available resources.

Under theoretical models of market economics you refer to there is no such thing as long-term economic profit. That's because profit is only realized by moving the economy closer to the ideal state, and in those theoretical perfect-information perfect-competition models you're already in the ideal state. In the non-theoretical world, however, things are never that ideal, and opportunities exist to earn a profit by addressing those deficiencies.

> It means you are benefitting from things that are bad for society, like imperfect information and barriers to entry.

I agree with you 100%. If society didn't have problems then there would be no opportunity to profit by offering solutions. That doesn't mean that you're responsible for those problems, however. Imperfect information is a fact of life, and providing better information is one perfectly legitimate way to earn a profit. Where barriers to entry exist, finding ways to break down those barriers is another way to profit.

Now, if you're creating new problems for society, such as spreading misinformation and erecting barriers to entry where none would naturally exist, that's obviously a problem. Negative externalities such as these require restitution to the victims. At this point we've left the economic realm, however, and crossed into the domain of politics.
In the US, there was a strike last year by teachers in West Virginia where one of the demand was to shelve a program that would force them to war Fitbit or pay $500 in premiums more every year: https://www.thenation.com/article/the-west-virginia-teachers...
> -- oh, no, you don't need a back up

:wink, wink:

If you care about your team, you'll let them know what's really going on, no matter what your exec said.
"The existing providers unfortunately have decades of vendor lock-in due to them owning the database."

But if they support FHIR APIs to get the data out, that becomes pretty irrelevant very quickly.

They can still be the "official" store of record for the data. But if third party tools can hook in through FHIR APIs to read and write the data, you just need to get buy in from the doctors and clinicians to use your better UI, or better workflow, or better data analysis tools, and the EMR is suddenly relegated to a dumb pipe.

The EMRs will resist this, of course. But I don't know if they have much leverage. From what I can tell, doctors despise EMRs and just see them as an inefficient tool that just adds more time spent documenting and less time spent with patients. For doctors, paper was probably a more efficient tool with a better UI for documenting their patient interactions. The EMRs are there to serve regulators and administrators.

So I think the pressure for EMRs to support open standards will be huge, and will be very hard for EMRs to resist.
My Grandfather did a similar thing. Small town doctor all his adult like and lived a very heathy life. Smoked up until the day he realized it was very bad and never looked back. Too bad my grandmother couldn’t kick the habit.
A Closer Look at Medieval Lent’s Toughness
[Citation Needed]

And if you are just an armchair cardiologist and you cherry pick one or two publications that suit this conclusion, well...
It's weird that this much quality went into the guts, but they couldn't make the cable on it a little more sturdy. I use mine sparingly, but it feels like it's going to break if I look at it the wrong way, and I've read that some people have to replace it every couple months.
Technology is wonderful, we have managed to become more centralized and less free with it.
Hands on with the 56-Core Xeon Platinum 9200 CPU Intels Biggest CPU Package Ever
Wow they really did. I didn't see that coming.
Show HN: Clerk – Log Agency for Android
I disagree. The data format is well defined, but how those documents interact with each other is still a jumbled mess.

There's also so much extensibility that someone implementing it could just throw away all of the default fields in a patient's record and create their own, and we're right back to a mess of records that are useless across systems without having custom handlers.
> but it's like we're breaking aspects of society.

If anything, we're returning to the historical norms. Using genetic analysis of the Y chromosome, ASU researchers were able to conclude that the male:female ratio was about 17:1. Meaning that in human history, one man made 17 women pregnant, on average [0].

[0] https://psmag.com/environment/17-to-1-reproductive-success
Whatever they will be doing will end like Obamacare. There may be some changes around the edges but the fundamental problems of US healthcare won’t even be touched. The incumbents are way too entrenched and their propaganda is very successful with a lot of citizens.
> Personally, I’m amazed whenever I use it but I always wonder for a moment, “what if Apple just made what people wanted?”

"What people want" is pretty slippery. For every person I've heard complain about needing the dongle, I've known at least one or two others who exclusively use the wireless ear buds and wouldn't go back. YMMV.
Multics, while not a 'massive' sales success in retrospect, was certainly not the failure commonly believed and wasn't treated as one in the press of the time - at least not until after the decision was made by Honeywell-Bull to phase out the Multics (and CP-6) products to focus on GCOS.

"Honeywell is having considerable — and surprising — success with the ultra-secure Multics operating system … Besides 3-5 systems within Honeywell, Multics has been installed or committed within Nippon Electric, Rome Air Development Center, USAF Data Services Center, and Ford" was widely reported in the mid-1970's industry press.
Introduction to Test Driven Development (TDD
> If there was an existing AI solution in place anywhere in world capable to detect a suicide, I'd agree - but there's nothing even close to that at the moment.

Should we let the technical infeasibility of them profitably solving a problem that they themselves have created be our moral compass?

> You can't blame a company for not using something that's technologically probably not even possible to make reliably today.

The point IMO is not to assign blame. It's to create legislation for the betterment of society. You can agree or disagree that it would be better, but don't reduce it to a blame game.

> And what if it's not "morally scalable", you shut it down? You break it by force like it was done with Bell system? Would having "Face corp." and "Book corp." really solve any of these issues, which are fundamentally a problem of human nature?

As I said, as far as I'm concerned, that's their problem. You implement the legal framework necessary to uphold a desirable moral standard and let that have its effect on the market. In those terms it's irrelevant how Facebook fares.

And no, this is not fundamentally a problem of human nature. Millions-to-billion user social networks have only been a problem for a brief moment of human history. Much like other problems throughout history it might go away some day. Not by itself, but by systematically working on improving the human condition.
By the sounds of it the first thing you might be missing is how good your current role might be...

You're clearly not being considered as an equal partner, which depending on what you're considering walking away from, whether the others have already put funds and sweat equity into the project and how relatively unique your respective talents actually are (and when/if you can reasonably expect to start earning a decent salary) might be acceptable or might not. You might be able to negotiate the equity percentage but probably not that starting assumption. The job title split also sounds suspiciously like the "chairman" might not be doing as much day to day work as you and the CEO, though again in some circumstances he might be backing it heavily enough for that not to matter. (It's probably difficult for you to provide much more detail without it being identifying though)

Seems perfectly reasonable to ask prospective cofounders about their experiences with all the startups they've previously founded or invested in, and possible his answers on that (or even just the tone of how he talks about people he's worked with and backed in the past) could be revealing, particularly if, unbeknownst to him, what you're really trying to find out is why someone he invested in thinks you should steer clear.
site seems down. google cache: https://webcache.googleusercontent.com/search?q=cache:ckxU-A...
HN hug of death?
"503 Service Unavailable"

Here's the Google Cache link:
http://webcache.googleusercontent.com/search?q=cache%3Ahttps...
In a monogamous society that has roughly equal men and women, everyone has the opportunity to reproduce. We're talking about a specific demographic that is struggling. In other words, those 18-29 men not having sex now (probably) will when they become 30-35. By that age most people are settling down into monogamy. And those men will be (probably) be in a better economic situation and therefore more desirable as mates.
I am pretty convinced that this greatly degrades audio quality on my aux headphones. Bluetooth quality is normal, but with this cable, I can hear the difference. When plugged into an amp/speaker the grain is so abundantly obvious (compared to a BT or AUX connection)
Because Node.js already provides low level network access, while in browsers fetch() is the (second) lowest abstraction you can get to.
Didn't know about that. To be fair though, it wasn't deprecated, but migrated to another service. And the migration guide looks extremely simple (effectively just change some config vars).
The irony of you calling me a jerk is delightful. As they say, when debate is lost, slander becomes the tool of the loser. Since the debate is over, so is this conversation, as it certainly cannot be productive (but then again, you never did intend for it to be).
> But guess what? No one wants it

With 794 reviews, clearly some people want it. The bad reviews tell us more accurately that; "no one likes it".
Elastic is a distributed index which can't be said of Bleve afaik. Therefore, it's more like Lucene.
The problems I see with limiting the scope to single function IO are

1. JS is dynamic and a single function can do a lot, even if you try to stub out the world.

2. from a product perspective it would be hard to communicate what is going on.

3. Perhaps console logs could cover a lot of these cases.

Does that make sense? What are you thinking of?

---

We definitely want to make it easy to visualize function calls (inputs/outputs). For instance,

- see outlier function arguments (the time the first param was null) or the function returned early...

- see outlier call sites (the time when the function was called from a different call site)

- see outlier timings (the time when the function called when some other state was null or a promise was pending) i.e. race detection

On the other side, we would love to help users see the impact of a function call. For instance,

- program slicing: the other code that was run because this function was invoked

- data tainting: the data that was either read or written to because this function was invoked
Wow. These are absolutely wonderful resources. Thanks for posting them
I have never seen them increase prices. Do you have a specific example of a service that has gotten more expensive?
Cloud Messaging was technically an Android API, not a part of GCP. (The admittedly confusing name predates the launch of the GCP brand.)
In the years that have passed since switching to an iPhone without a headphone jack, I have never once needed to use that dongle. Bluetooth more than covers my use cases. So the article is correct, I don't want it, but I also don't need it.
We've reverted the title from “Node's oldest NPM package is being deprecated”.
BioWare Working Staff to Tears and Calling Its Mental Abuse “Magic”
Reasons to not use GitHub's profile contribution activity
> who wants to give their kid with Type-1 diabetes anything but the latest and greatest version?

Lots of people. FYI, this is the strategy of several generics shops. The challenge is doctors' reluctance to prescribe them.
It is a stupid way to achieve the goal because if you're legitimately trying to mitigate other specific things you could tax for those things. E.g. for one example you mentioned allow new development, but set trash disposal fees at some absurd amount.

It also assumes a zero-sum economy. Once you have more population density you have more of a tax base to pay for all those things, and some fixed costs go down as density goes up.

The claim that public transit of all things is going to get worse with higher density is, frankly, ridiculous. If it really persists as a problem you can use the extra money from the new tax base to bring in urban planners from Tokyo.

> I have no solutions[...]

I have one to address NIMBY-ism everywhere: We say sure, you can have "protected views" or whatever, but then you need to pay market value for those things.

We'll see how long that lasts when people need to pay out of pocket for the opportunity cost of not constructing a skyscraper just to occasionally enjoy the view, as opposed to incumbents getting to vote for "free" and getting the direct benefit of their property values rising.
It does. It's small and hacky, but powerful enough to do things like http://p3rl.org/Moops
Gum bacteria implicated in Alzheimer's and other diseases
The attitude of those in the oil industry does not help this at all. I work in oil and talking politics to those I work with just makes me sad. There is a lot of anti-government hate. People are still resentful about the National Energy Program and that ended 30+ years ago. Its kind of a mess.

I think its the notion that all the provinces are competing against each other, and that under any oil program some provinces will win and other lose that really holds us back. No one can see that we can all win by collectively working together. It doesn't help at all that there are now moneyed corporate interested involved that are not interested in seeing any changes take place.
A Taste of Dynamic Typing in Java Using the Var Keyword
As long as you're selling the emperor's new clothes, I suppose you're right.
Note any more! The t-note recently inverted.
Might be worth adding a [2017] tag.
Cross-Lingual Transfer Learning Halves Data Requirements to Bootstrap AI Systems
Here’s a blog post I wrote recently on a similar topic:

https://www.tablix.org/~avian/blog/archives/2019/02/google_i...

On my website, the Google index coverage is clearly falling with age of the content. According to the Search Console only about 60% of my posts from 2006 are indexed.
I work in healthcare, and even after reading the entirety of Google's blog post about this, I still feel uneasy.

I'm not sure what the root of my misgivings are. Maybe I just don't trust Google anymore.

One thing I can put my finger on is the fear that Google will one day pull the plug on this project like so many others. And now we're not talking about social media posts being in jeopardy, but people's lives.
Like pretty much everything, there's a U shaped curve. Low cholesterol can be bad, just as high cholesterol can be bad.

Plus, it could just be a side effect of something else and we don't actually know what the underlying cause is.
That's certainly what the government wants you to believe :)
I would've preferred a headphone jack as I've already lost mine.
Except China as a state isn't our ally or friend. Their interests lie primarily in furthering their own political and military power, and secondarily benefiting their own population. They're more than eager to steal technology, then use that new-found knowledge and ability combined with massive government subsidies to drown out foreign competitors locally and abroad.
THE POWER BROKER is one of the most fulfilling and detailed and well-researched books I have ever read in my life. Caro is the best biographer I have ever encountered on the page. The richness he puts into the history he tells is truly unbelievable. After reading that book I felt like I deeply knew — and hated - Tammany Hall, hahaha
That's a great point. Tracing quickly becomes slow and memory intensive.

I think you would enjoy this write-up. WebReplay is explicitly not tracing for that reason.

https://developer.mozilla.org/en-US/docs/Mozilla/Projects/We...
> SEO seems to have become a huge obstacle course that smaller websites can't play.

Absolutely right. I recently started a blog, and was disheartened to learn that I have sign up for accounts with several search engines, conform to their standards and rules, give them a bunch of data... and still sometimes have mysterious issues with indexing with no real recourse. How much time and effort do I really want to spend to play the seo game? I have a job, projects, and hobbies, I don't have the time or patience to play their game of "let's fuck with things randomly until you get indexed and ranked higher". That was fun for a few hours, but I'm done with it.
I'm sure it's not easy, but...
1) a support line offers support to the end user, which is different; I'm talking about filtering out the emotion from the content
2) most people who could do this, do not know that they could, that there is a need, or how one would volunteer to do it
3) the same person would not have to process all feedback, just as much as they have time for; at least some of the pile of feedback would be processed by someone other than a dev
4) the non-technical nature of the person is actually helpful, because that is usually where the originator of the feedback is coming from, and the job of this person would not be to determine the fix, but only to separate content from emotionally motivated criticism
It wasn’t “free” in terms of money. Neither were the tires that came with my car.

It’s also not free in terms of time spent thinking about them. Like all dongles, I have to remember to bring them wherever I go in case I need them.

They’re an engineering marvel, no doubt about it. I just wish I didn’t maybe need it.
Processor Design: An Introduction
If we talking OPSEC, PIA of out, as any other with your payment info. You'll need to have few different anonymous VPNs and self hosted VPNs/proxies to make random chains. Pay by coins only, throwaway emails.
Data: Social Lenses Lead AR Usage
The flaxseed oil method has worked great for me so far. But it is indeed a great internet debate. :)
I walked the length of Manhattan. Here is what I found
>100,000+ people marched in the street against it[0]

>[0] https://en.wikipedia.org/wiki/Protests_against_the_Iraq_War

These just seem to be anti-war protests. I'm not seeing anything that suggests they knew it was false, or that that was the reason for the protests
It would be much easier if the next person were the creator of the code, but instead we have this machine cog mindset of "we can just throw any of our developers at any given problem whenever".
Interesting. What updates to enterprise key management exist that are improving this? Like Thales/Vormetric and Ionic Security.

> https://www.thalesesecurity.com/products/key-management/inte...
It was a joke, I forgot the
This was launched last year:

https://www.blog.google/products/google-cloud/google-cloud-h...
An engineering marvel necessary because of product design stupidity.

One can neither use the same headphones for a Mac and iPhone, nor charge an iPhone from a Mac using the cables that come with the devices.

I barely use that crap adapter because it's inconvenient. Thank goodness Macs still support headphone jacks.
Give it a few years I think most people will look at this like removing the CD. The wireless audio experience is mostly better. Airpods for example connect and disconnect effortlessly. Being able to walk all over the office while on the phone has done wonders for my pacing.
I understand where you are coming from. I have a couple of these of my own.

Apple probably doesn’t want to make these stronger than the things the connect to: eg headphones or the phone. Within certain load profiles the weakest component will suffer most of the wear. Would you rather the connector broke on the $9 adapter or the $1500 phone?
Cameras have been found in hotels too.
Youtube is like an election with a trillion billion candidates all competing for your attention, not 2
You can still read about this: https://evil32.com/
I'm having trouble with the google cache version too, so here is the archive.org version: https://web.archive.org/web/20190408150115/https://misfra.me...
This is doable with hnrss if RSS is good enough:

https://hnrss.org/replies?id=devwastaken (replies to any of your comments)

https://hnrss.org/replies?id=19599229 (replies to a particular comment ID)
Serious question, if laws won't fix it, how does India do it? From my very limited understanding India doesn't have these high costs?
Does Herpes Cause Alzheimer’s?
Why don't the dogs kill the penguins?