skysight-inc/HackerNews huggingface dataset:
Not an expert, so experts please correct me if I'm wrong:

* CRISPR doesn't do all of the time what you want it to do. It is quite error prone. What's done usually is that you apply it to multiple cells, check each of them, and take the ones where it worked out. Usually only a fraction has the changes that you wanted.

* Many multicellular organisms like humans grow from a single cell called zygote. Furthermore, very early embryos consist of a ball of blastomeres that each, if you isolate them and put them into the right conditions, can form a full organism.

* So the most practical way right now of editing genome of mice or humans is to hijack that stage, to use either multiple zygotes or blastomeres (not an expert, not sure which of the two is actually used) and apply CRISPR to them, then take the successful results and gestate them.

* In mice as well as other animals like zebrafish, this kind of editing is pretty routine already. But in humans, it's never been done except for one Chinese scientist. We don't know at all whether there are any adverse effects of the therapy, something we overlooked, etc.

* Also, the gene can be identified prenatally in a sense that you sequence the genes of an embryo still in the womb but that is only possible at a much later developmental stage than the blastomere stage so your options of editing aren't better than the options you have in a living human.

* There is another option that doesn't involve CRISPR: If your parent has a healthy copy of the gene and a non-healthy one, one can perform IVF multiple times, take one blastomere each from the ball of blastomeres, test them for the bad gene, and gestate the embryos that have only healthy copies of the gene. If every at-risk patient gets such a therapy, this approach is enough to deal with Huntington's disease and many other genetic diseases but it limits you in animal or plant breeding to mendelian genetics, basically making your life harder than it could be if you want to combine multiple beneficial traits. Here, CRISPR based approaches give you a big benefit, as long as you can deal with the anti-GMO crowd.
Yes and yes :)
Yes (and it's probably also good for snack sales.)
Native apps often (not always) get you not just performance, but also efficiency, no annoying browser chrome, adherence to platform UI conventions, and utilization of platform-specific features (no lowest common denominator syndrome).

Electron apps can get rid of the browser chrome at least, but it comes with the cost of a redundant copy of Chromium for each app, which is worse than running in-browser in terms of resource consumption.

Web apps would be great if they could deliver the things mentioned in the first paragraph on top of their security/privacy benefits, but I don’t see that happening any time soon.
I just wanted to second this. It's astounding that there continues to be a large dispute over the influence of Stirner on Nietzsche.

I personally like Nietzsche's ideas but really don't enjoy his style of writing. Stirner on the other hand touches on many of the same ideas that Nietzsche would later, but is both an easier and genuinely hilarious read. The Ego and its Own is an absolutely brilliant book, that should have at least the level of popularity that some of Nietzsche's works have.
It's the managers job to run the company in a way that they never have to lay off employees.
Spotify doesn’t allow in app subscriptions - so it’s not paying the 30% cut.

Should we also stop Google from surfacing reviews, hotel reservations, etc before competitors since it doesn’t have to pay itself for top placement?

Should we stop console makers from also being publishers since they don’t have to pay themselves a licensing fee - yes physicsl media from third parties have to pay a licensing fee.

Should we stop physicsl distributors from having store brands?
Lawrence of Arabia comes on two discs! If you mux together the entire film (just the main feature), it's over 57 GiB!
> the main deceptive thing is calling this acquisition a “successful exit” — it was far from that!

Corporate speak. Put a positive spin on everything!!!
There is a greater mathematical correlation between Latino surnames and illegal aliens who are staying in Motel 6's than there is between say, Japanese surnames and illegal aliens staying in Motel 6's. Do you deny this?
What does "SJWs" mean in this context?
Android ViewModels: State Persistence – SavedState
No, a 4k is a 4k. The aqua man I just got has Dolby Atmos and HDR
Also, IxJS and RxJS provide some really nice sugar for working with higher-level abstractions around "pull" and "push" flows. The protocols associated with `Symbol.Observable` and `Symbol.asyncIterator` have small surface areas, so it's not difficult to hand-write implementations (using generators and async generators) to adapt code that wouldn't otherwise fit in the flow.
Actually I'm fairly sure that Charter, due to an agreement with the FCC that expires in the early 2020s, is the only major provider in the US without at least a soft cap. Comcast in particular is infamous for their low caps.
[..]Twenty-seven years ago, when California became just the second state to enact a law establishing charter schools, state leaders framed the experiment as a modest one that would allow only 100 schools at first. Free-market advocates saw charters as a way to empower all students to choose from a variety of schools. Other supporters envisioned them as laboratories for testing new teaching methods and then bringing successes back to traditional public schools.

The new, privately operated schools would be government-funded and tuition-free. They would unleash creativity by liberating schools from many of the state education code’s rules. But to ensure that they lived up to their promises and spent public money properly, they would have to be vetted and overseen by governmental bodies, beginning with the school districts in which they were located.

That was sufficient check and balance for the civic-minded individuals who ran many charter schools. But as the number of charters in the state grew, the same law that allowed many founders to try new ideas with great success created opportunities for others.

The law allowed for a multitude of different bodies to serve as “authorizers,” watching over the new schools. It gave oversight power not just to the state board, but also to each of the state’s many school districts and county boards of education — regardless of whether they had the ability or inclination to properly police the independently run schools.[..]

[..]About 330 government entities have the authority to authorize and supervise charters in California. By contrast, Texas, the state with the second-largest number of charter schools, has 18, according to its state education agency. New York has two active authorizers.

Los Angeles Unified, the nation’s second-largest school district, has an entire division devoted to overseeing the charters it authorizes and is considered one of the state’s most robust monitors. But the roster of charter authorizers also includes school districts with colorful histories of corruption and financial mismanagement. Some are so small that they have fewer than a dozen employees in all, with insufficient resources to be effective watchdogs.[..]

<<<<<- Gone bad.
A tiny bit of spent fuel, and billions of toxic and unrecyclable cells are far different problems.
If you notice bugs, you should do more maths and get tweaking. Wait... something's not quite right there.

On a more serious note: the biggest barrier to correctness I've encountered is doing things I don't understand. I also care less and less for being paid to understand particular things, it's so much worse than just being paid to do work.
If you believe that illegal aliens are coming to the US for the express purpose of civil disobedience (I think that is a fair summary of what Rosa Parks was doing), please show evidence of this.
Reading the source doesn't tell you why they chose that route or what the tradeoffs are.
The problem with this article, is that as a supply sider, the author has no compassion for the lower classes, who are hurting the most through these policies. It should be no surprise that the divergence between labor productivity and real compensation began diverging immediately after the collapse of bretton woods (and the concomitant widening of the gap between the rich and poor); after all, inflation is basically the means by which the government steals from the poor to give to the rich, in a compounding fashion (slow though the time constant may be)
That's the reason no one wants to say, but I'm sure the percentage is pretty high among yc users that also subscribe to netflix DVD.
Maybe that's a failure of the market? If the market is pushing people to do things that aren't what we want then "its the free market" isn't a defense.
The sale of apps basically died years ago. Most of the revenue from apps is either coming from in app purchases of consumables or subscription service that are cross platform.

Music that you bought from iTunes has been DRM free for ages.

Most movies purchased from iTunes are transferable to Google Play, Amazon Video and Vudu vis the Movies Anywhere app.
I can find 1MM jobs that aren't needed in profitable companies.
Spotify hasn’t allowed in app purchases of subscriptions for years.
> 3 quid coffee represents approximately 5% of your daily income.

So 60 pounds a day is minimum wage in UK? It seems to be very decent middle class income rather than minimum wage. Or maybe you meant 50%?
The "Not Now" example looks disabled to my eye just as much as the disabled example.

I think the rule here makes sense as far as design works now, except that "Not Now" example.
We called them flippies.
Yes! I've told people about this before and people either hate it or love it:
"Holy Shit - An Incredibly Epic Playlist" | https://open.spotify.com/user/ruhin94/playlist/0bG1EMQkukEeO...
The problem with the whole "screen time" premise (and maybe this is her whole point) is that there's no differentiation made between good and bad screen time. Just looking at someone who's looking at a screen, it's impossible to tell what they're doing. Or before that, before phones became smart (but after they became mobile), I can recall just seeing someone in the store, talking loudly on their phone, and being like "what a douche." But it could be their nearly-deaf mother calling them from her deathbed or something.
It was social pressure, and I was pretty much the last person to do it in my immediate circle of friends at that time.

Down the line what helped me the most was advice from grown ups that I had a lot of respect for. It just felt different when someone was saying you have to stop and those people didn't necessarily have a way to know other than to look at you.
What percentage of attempted crossings result in an apprehension? My impression of ICE/border patrol is that they're an ineffectual agency[s] who're wasting my tax dollars. Basically a glorified jobs program for mouth breathers who can't hack it as real cops, not unlike the TSA. Is that not the case? Are they actually good at their job?

https://www.forbes.com/sites/michaelgoldstein/2017/11/09/tsa...
Sometimes I wonder if people are actually really good at thinking in groups but the thought process is just too terrifying and different from what we could understand as individuals
The implication being that all those companies were cooperating and not being inadvertently tapped. This is not a given and from what I've seen the later seemed more likely, without discounting the existence of companies that do cooperate on an ongoing basis.
LogMeIn is where products I genuinely loved go to die.

Years ago it was Hamachi (the LAN-over-internet software). Then it was LastPass and via it XMarks (itself acquired by LastPass shortly before). XMarks suffered much more grievously than LastPass — I suffered data losses on multiple occasions before finally throwing in the towel.
That processor is really old 6th gen and underpowered. I got a faster and newer quad core 8550U in a Lenovo T480 with 9 hours of battery life in dual batteries. Plus, I have a 1 TiB Samsung 970 Pro. Sure, they do better on firmware tracing and privacy, but if it's not a competitive and good value, it's risking not being a survivable business model. The PC business is competitive and runs on slim margins, so if they shirk or shrug at keeping up, their business is going to die.
> You sound like a typical religious fanatic who tends to deny the fa...

FWIIW, I'm an atheist: overtly and publicly so, under my real name even. Not that this should matter; if I were a foaming religious looney handing out bibles on a street corner; everything I said is still a historical fact. Since we're psychoanalyzing each other; I used to be a smug Dawkins tier ignoramous myself; I grew up, noticed most of the physicists at LBNL who were worth two shits were religious and read a book or two. Your apparent bigotry against religious people is offensive and stupid, and your understanding of the history of science, or even what science actually is, is sorely lacking.

>You're bringing many names and points, writing paragraphs here, but you are yet to quote a single source...

> ... on the definite lack of attention to punctuation...

Projection is a hell of a drug.
What’s weird about this article is that it fails to mention one of the primary USA cultural reasons — perhaps the primary reason — for the increased cultural popularity of this drug: the increased popularity of chemsex.

I was a pretty low-functioning meth addict for years, both overseas and in America. Disgusting cuts on my hands and feet that would never heal, lost a tooth, the whole nine yards.

What fascinated me about doing meth in the Bay Area was the police force’s reluctance to harass, question, or even stop me when I was clearly a fucking tweaked-out tweaker. Eventually I realized that I was protected by the phenomenon of chemsex: cops didn’t stop me because they thought I was gay and thus were scared I would call them out for homophobia. (And they were right, lol)

Doing meth in the Bay is so much easier than other places it’s kinda disgusting TBH. there’s a line between tolerating a drug and enabling drug use and the SFPD definitely crosses over that line into the enabling department.
>I flag everything that isn't tech and startup related But is that appropriate?

No. Hacker News is not, nor was it ever, exclusively for tech and startup content. Flagging should be reserved for particularly egregious, low quality, trolling or spam threads, not for threads you find personally uninteresting.

Accept that Hacker News users find things engaging or relevant that you do not, and either ignore those threads, or hide them. You can also post more of the kind of content you want to see here.
كلمات اغنية صدفة راغب علامة
It's an atmosphere. An air of dismissiveness that is hard to pin down. It comes out in various ways. Dismissal of estimates. Removal of autonomy, micromanaging. Transparent attempts to buy productivity with token gestures like, pizza or beer, when management is at risk of looking bad. Not having retrospectives, if they are held, nothing is ever taken on board and there may be slight eye rolling going on. Fictitious deadlines, that arise roughly every 2 weeks, plucked out of thin air to try and stress everyone out to get them to work harder. Just a very faint whiff of contempt hanging in the air, the developers never really belonging in the company. Like we are interlopers, a necessary evil, like... like an air conditioning unit in a boutique hotel. You cant build it into the wall because it's not a purpose built building and theres no space, but you also cant not have it in the room. So it just kind of sits there clashing with the otherwise well thought through and lovingly created decor. Something to be tolerated but also to be avoided.

I mean developers dont help themselves, they tend to let their desire for purity and craftsmanship get in the way of getting the job done. They over state the case for various development practices and management can sense it. Somehow the two kinds of personality just tend to lose faith in each other and it all unravels, until there is no trust left and all but the thickest skinned developers roll off.
> "People assume that our customers must either be super seniors or folks that live in the boonies with no internet access," she says. "Actually, our biggest hot spots are the coasts, like the Bay Area and New York."

"Geographic profile maps which are basically just population maps"

https://xkcd.com/1138/
> So, libertarians, but without the money?

Nope, he described leftists and left-leaning anarchists.

Libertarians are supportive of the concept of private property and know one can homestead (homeless-stead?) on property that belongs to another person.
> No, those who consume more have benefited more.

Usually you can consume more if you have earned more i.e. have more buying power. But I know that's not what you mean.

> Earning more is just the opposite: it shows that you've provided more benefit to society than someone who earns less.

They're not very strongly correlated. It's possible to provide value without seeing much in reward (janitors, nurses, schoolteachers), earn plenty without providing much or even negative value (telemarketers, those opioid manufacturers we're hearing about), or both provide value and earn $$$ (Google, StackOverflow).

In any case the taxman doesn't care about "value" provided to society because it's such a nebulous concept. The IRS doesn't let you take deductions for adding value or add extra taxes because you're a telemarketer. Even if you provided a ton of value to society while getting rich, you still got rich. And your society's enforcement of laws and property rights, educated citizenry, and infrastructure were likely crucial to this.

> The ones who benefit most from society are the ones who manage to consume more than they earn.

This is true in the case of those who inherit large fortunes/trust funds and don't work. Tax laws favor them greatly at present (lower estate and capital gains taxes).

It's not true at the other end of the scale though. If not having a job and being on food stamps/medicaid/unemployment was really all that great, you'd have far more people looking to get in on it. It's actually a miserable situation that most people work their hardest to never fall into.
I'm excited to read this - I similarly found Nietzsche somewhat excessively cryptic. Thanks for the recommendation.
There hasn't been one.
> my strong overall impression was that he essentially despised all that went before him,

He didn't think well of the state of European philosophy, but "despised all that went before him"? Not at all. He didn't think very highly of his contemporaries working in European philosophy (and politics), but was deeply embedded in classical philology.

> rejected Western values of good and evil (obviously, and as some here do)

That's a broad brush. To use a slightly narrower brush, he starts from the (by no means unique!) position that no God is the source of morality in the world.

> and left the reader with nothing beyond the essence of an Aleister Crowley "do what thou wilt" disregard for the idea of objective good and evil.

Sigh. At the heart of Nietzsche's philosophical project are attempts to re-ground morality on something other than the crumbling foundations of 'Western values.' He gave you a dozen books with which you can think along with him and try to solve that problem.

If you can't get more than 'do what you want' from reading Nietzsche, that's not his failing.
I said divine miracle in my initial reply for a reason. I experienced what is known as OBE or Out of Body Experience while laying down on the floor, high off of my senses. I never did any drugs after this apart from a smoking habit I had to break. So, to summarise, that was 3 years worth of addiction resolved in one evening. Over the years I have understood the experience more, but not something I want to share at this time as I would like to include that in my book.
Is there any documentation? The aeplay.org site looks still to be mostly developer oriented.
> Don't hard drives use MB (to inflated advertised capacity? You decide) as standard.

They do, but that's not what diskettes did. Hard drives use KB = 1000 B, MB = 1000 KB, etc. as units. This makes the number on the side of the packaging larger, so it's good for marketing. They used to use 512 B sectors internally. (Today, HDDs have moved to 4 * 1024 B sectors, or 4 KiB, I believe.[4])

([1]) 3½" diskettes were 1474560 B (1440 KiB). If we use the programmer's "KiB", where 1 KiB = 1024 B, 1 MiB = 1024 KiB, we get 1.40 MiB. If we use the marketer's 1 KB = 1000 B, 1 MB = 1000 KB, we get 1.47 MB. The only way to get that 1.44 number is to mix the two: 1474560 B / (1024 B / KiB) / (1000 KB / MB). This is of course utter nonsense. But I guess it got to a point where it would be weird, I guess, to not label your packaging as "1.44 MB", and so it was, until the USB drive killed diskettes[2]. (This mix happened because the size was "1440 KB", and from there, someone moved a decimal point without understanding why that didn't make sense.)

[1]: I'm going to use the binary SI unit prefixes (https://en.wikipedia.org/wiki/Binary_prefix) for clarity, but back when diskettes where popular, 1024 B was notated as 1 "KB", and it was up to context to determine if the author meant 1024 B or 1000 B. The binary prefixes didn't exist until '98, let alone were they adopted, and diskettes would die a quick death soon after that.

[2]: Or CDs, if you had a burner. Or Zip drivers or Jazz drives if you did that.

[3]: The "1.44 MB" storage device was rigid. It wasn't floppy in the least. It was a diskette. The 5¼", that was floppy.

[4]: https://en.wikipedia.org/wiki/Advanced_Format
Perhaps it's cognitive bias rather than hate. Being so quick to label and bucket people negatively only pushes them away rather than convince them. This person seems reasonable and amenable to changing their mind.
In what way does it remind you of pushes to bring back nuclear power? Can you elaborate? Genuinely curious.
Boeing's 737 NG was manufactured using unsafe structural components (2010)