skysight-inc/HackerNews huggingface dataset:
Interesting work. The clonal frequency of the TCRs was included in the model. Tumours often have more clonal TCRs, whereas normal tissues generally do not, so I would imagine this would be an important feature (in fact including the TCRB prevalence gave better predictions than the 4-mer prevalence for breast cancer). Can't see in the paper that they ran the model without the frequency feature, or even ran it with just the frequency feature. Building a very simple model probably would have been a more salient comparator than shuffling the labels.
Getting 'fit' is very far away for a lot of people, MDD or not. That's not a reasonable aim for positive effects on depression. If we can get positive effects from regular exercise, it's great. If it requires patients to get 'fit', it's really not.

> Also, once you get in a good shape, it's really not difficult to stay in it. Contrary to what anyone says.

How old are you? This: "change your approach to exercising, eating, sleeping, etc. There will be things that you have to sacrifice" is one of the hardest things to do in life.
I suppose the gov could ip block 1.1.1.1 and 8.8.8.8 just as easily.
Hah exactly :)

Same goes for functions, classes, React components, DB tables and everything else.

Just model it as close as possible to the real world. The world doesn't really change that often. What does is how we interpret and behave within it (logic/behaviour/appearance on top).

If you have a Label and Subheader in your app, create separate components for them. It doesn't matter that they look exactly the same now. Those are two separate things and I guarantee you more likely than not at some point they will differ.

My rule of thumb is: If it's something I can somehow name as an entity (especially in product and not tech talk) it deserves to be its own entity.
What ISP are you on? BT blocks libgen but NordVPN seems to work just fine.

Of course if they block the whole VPN list you can just rent a tiny instance in a cloud somewhere, though that seems like enough work to bother most non techies.
Beware, the sfgate.com site messes with your browser history and back button. I still regard such design as wrong-headed and bad.
Nasa: India's satellite destruction could endanger ISS
Indeed, and we should all keep what you say in mind. But in order to be effective you first need to be productive. A lot of people struggle with focus, motivation and energy to do things.
20 hours for Rimworld? I've spent nearly a hundred in there and never even got close to endgame. That is a sandbox game without an end - however, one with constant entertainment though.

But I feel you about longer games starting to feel like work. I really want to like the Witcher 3 for example, but there's just so much content in there. I've started my playthrough two years ago and still haven't gotten to the end of the game. Or, I thought I did, but turns out it wasn't yet. And then there's some DLC which also got great reviews and promises of a huge amount of content.

Currently I'm playing Mass Effect: Andromeda, which bombed because of reasons but it's a pretty good game with a ton of content, can't go wrong for €7. Its missions are episodic enough that you can play for an hour at a time if you're limited in time.
My dad has (probably?) paranoid schizophrenia, and life stress was definitely a trigger for that.

I am skeptical of tcj_phx's advocacy of resistance to lithium. It's a very effective drug with horrific side effects, and it seems to have worked pre-ECT. It sounds like the psych involved is aware of the safe limits for lithium, as hitting the maximum safe dosage for one drug is usually what (in my experience) causes psychiatrists to start mixing different meds. (Which comes with its own problems, since as side effects multiply they get harder to understand.)
A simple guide to create CocoaPods
Google bans swear words from internal files and URLs (2018)
In the UK an entire generation of professional developers started with BASIC on toy machines like the Spectrum, before moving on to professional languages, often after a degree.

Calling it bullshit is actually being far too polite about it.
Anecdota about depression and exercise:

*

It's not getting in shape what lifts depression, it is physical activity in itself. You generally feel better after exercise.

It becomes much easier to hit the gym after realizing the reason to go is simply to feel better. Instead of thinking _I don't feel like going to the gym_ the correct cognition is _my medicine is there_.

*

There's a variety of options to exercise. Don't stick to running if you don't enjoy it (but you keep doing it because you feel better). There's a large menu of activities, at first try what is convenient, deliberately try many things and find what is more fulfilling to you.

*

With exercise nutrition follows quite naturally. It's difficult to navigate all the BS in nutrition, but in general eating fresh things closer to nature (leafs, fruit, veggies, nuts, lean meats) also has an impact on your wellbeing.

*

Often there are more issues other than lack of exercise. If you are socially isolated, if you are under constant stress, if your home situation is dire, exercise will help you cope with it but it's not getting at the root cause. Identify and work on the cause too.
Thanks. Yes, you're right. Not just Jigsaw (who are excellent, and I've been recommending their DNS app, intra, on news.yc for as long as I can remember), there are multiple other companies in this space (SecureMix, TheGuardianApp, KeepSafe, CopperheadOS, Proton mail/VPN, AdGuard), but not everyone is quite doing what I have in mind related to fighting trackers and censorship with a focus on 'one click and you're done' kind of simplicity (?)

I hope to get something ready to show you guys here on news.yc in may be 3 to 6 months from now.
I guess this is the point where you leave the general public behind. Lucky you.

Which fits fantastically in the discussion over at the San Diego Streetlight surveillance and the "Software engineers social responsibility"[1] vs. the fact that it will get worse if you make it mainstream.

Interesting times.

[1] https://news.ycombinator.com/item?id=19545668
Location: Romania, Europe
Remote: Yes.
Willing to relocate: No. I am open to travel and meet, but I work mainly remote
Technologies:
- ReactJS, React Native, Redux
- NodeJS, GraphQL, Docker, Linux (Ubuntu, Alpine Linux), Resin.io
- MySQL, MongoDB, Elasticsearch, Logstash, Filebeat, Metricbeat
Résumé/CV: On request
Email: catalin[at]charlietango[dot]co

I'm not interested in full-time contracts, I will consider only part-time or project work. Don't ask me to build your landing page; I usually build more complex systems.
Make a new account - the only thing that works.

Amazon has no qualms delisting businesses making tenth of megabucks on Amazon, and it is very unlikely that they will make an exception for a small business.
I think that only tells us about you, not about most people. Most people do not find the path to that outcome.

Also, do you think your productivity was equivalent to 32 engineers? Regardless of what your manager said.
Presumably the video is either faked or (more charitably) the customers were asked if they would like to try this new recipe. No lying going on in that last case.
This is a rather popular lie that ignores the facts on the ground at the time. No, the US car companies did not lobby against or destroy the streetcar industry, the growth of the suburb and government policies that promoted such growth managed to do that all on their own. The auto manufacturers just set themselves up to take advantage of this decline and the shifting of subsidies to road construction.

In this case culture (the shifting demographics that led to the initial growth of the suburb and the self-perpetuating cultural enshrinement of same) is what led and government/corporations followed.
Maybe this?

https://blog.applovin.com/hyper-casual-mobile-gamings-newest...
I spent years with 5 people on 12mbit ADSL2. I'd rather have that than virgin and blocking any day. I suffered Virgin for a couple of years and it was hell.

Now I'm on ~64mbit VDSL with no blocking at all on Zen. We pull 500G+ a month through it. Costs £37.49 a month.

They just rolled out 300mbit fibre as well so that's going in next month.

Speed isn't everything for me. I can QoS those problems away pretty well.
Not if you are an enterprise developer that work on a long lived stack like SAP.

It is slowly changing in our world but very very slowly ... Javascript is actually being mentioned at conferences now.
I have rather unpopular opinion about biking in most cities (it doesn't cover bike friendly places like Netherlands/Belgium/Denmark, but your usual place where bikers share roads and sidewalks with rest of us) - bikers often behave like assholes, especially but not only to pedestrians. Aggressive, arrogant, utterly ignoring red lights, zooming fast through crowds walking on pedestrian crossings. I had few near-hits myself when biker went maybe 10cm from me, doing 30+kmh, not even slowing down although he saw me.

Also have seen couple of incidents of biker hitting pedestrian hard only because biker was a total idiot and tried to get somewhere 5 seconds sooner. Fast bike hitting some old granny doesn't end well for her in any possible case. Fiancee who is a doctor had recently a case where biker hit pedestrian in same way, ignoring red light. Guy in his 40s was cca OK when brought to emergency room, but went into coma quickly due to internal bleeding in the brain. Dead within a week.

Maybe its this idiotic childish 'french' culture that I am exposed to here in Geneva (when you see them drive in France you know what I mean), but it really seems biking in the city brings out the worst out of people.

Biking elsewhere, in the nature, forests, unpaved roads, fields etc is something completely different, that I enjoy very much.
Hm, I don't want to know how much time I spent with 2048. Definitely fun for much more than a few minutes ...
Oops my Bad apologies to Steve Ciarcia
I'm working with really good people, as a remote worker and I have probably and objectively one of the best work conditions one can get without playing politics or being someone's "yes man" or something similar.

I am already paid extremely well and I am not a greedy person anyway.

So, 20% more means nothing to me unless I have the same conditions, which are so rare.. that I've never seen before.

If it means to wake up and deal with awful people, that's a definite no.

If somehow I can end up working with as good people as my current colleagues and bosses, I would only take the job if my current company doesn't suffer because of me. Yes, I am loyal person and it's probably looked down upon in this day and age, but it is what it is.

So, probably no.
I am saying that there are some studies showing gender segregation at certain ages may improve educational outcomes, largely depending on how it affects teacher behavior. Whether that means we should do it rather depends on whether we can get those teacher behavior effects in other ways and whether gender segregation would cause other issues (e.g. unequal resource allocation).

For some specifics that are pretty easy to find, see http://econweb.umd.edu/~turner/Lee_Turner_Gender.pdf for recent evidence that boys do may do better in all-boy schools, at least in some cultural contexts. There were a bunch of studies in the '90s that claimed girls do better with no boys in the class, due to teachers actually noticing them, but that effect seems to have more or less disappeared over the last 20-25 years.

In general, as in all things to do with kids and education the answer is almost certainly "it depends". Some children do better in a gender-segregated environment. Some do better in a gender-integrated one. Some don't particularly care. Hence all the caveats above about "some" and "may" and so forth. The hard part is figuring out when gender-segregated education is appropriate and when it's harmful, on a student-by-student basis. Unfortunately, public education is too cookie-cutter for such details.
The t2.micro is only free for a year, no? After that it's expensive vs normal providers, like aws stuff generally.
That is a tangential debate, but it is a false premise. Sport should quantify what unfair advantage is.

Two studies: https://ghr.nlm.nih.gov/primer/traits/athleticperformance and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993978/

The heritability of a trait is generally considered an estimation of the importance of genetic factors to that trait. For example, the heritability of athletic status (regardless of sport) is estimated to be 66% (4). Height, which is critical for success in some sports, is highly heritable, with about 80% of the variation due to genetic factors (5). Body type (having mesomorphic or ectomorphic somatotype) is also highly heritable (6). These somatotypes are classically associated with power or endurance athlete status, respectively (7).

Costa et al. (8) recently reviewed the existing family and twin studies related to specific endurance and muscular strength phenotypes. Aerobic endurance, as reflected by VO2max has a heritability of about 50% (9). Heritability estimates for muscular strength, and power range from 30 to 83%, depending on the specific muscle and type of contraction (8).

As a personal opinion, the reason why sport is split on gender is because of the spectators. You get more women to watch sport if you have a women sport team. You do not get more short people to watch sport by splitting the teams based on height. Thus we split on gender. It has nothing to do with fairness and everything to do with money.
s/downloading/uploading
proxy to afghanistan for free books <3 yalla yalla
It was more a criticism of the OP's Sysad's -

Though for the system I mentioned one of the reasons they employed me as a developer was that I was also a sysad on PR1MES - an early example of devops maybe.
As an outsider, and nothing close to an expert, the title sounds profoundly tantalizing, in terms of a means to hypothesizing a cure... Specifically, to my ears, "computationally identifiable" sounds like a new level of targeting accuracy?

So, hypothetically, what would it mean, if one could sequence a tumor, identify the receptors, then culture and replicate the immune signal to amplify it, train the host with a vaccinating agent, and then let the host's immune response mount a highly targeted attack to eradicate instances of the diseased genome?

Sounds like that's a pretty tall order for now? Or is it just presumptive, and fantastically absurd to believe things even work like that?
Those 2 libraries are the closest thing to the modern internet equivalent of the "Library of Alexandria".
I hope they don't manage to burn in down.

Yes, for now governments only caught up to DNS level blocking, but more effective measures will follow if we don't change the political willingness to withhold knowledge from the masses.
I added "what_the_fuck_are_okrs_craig" to the end of the URL in the hopes he gets the message when he looks in his 404 logs...
You have issues with WireGuard split tunneling in general or only on iOS ?

To make split tunneling work in WireGuard I changed AllowedIPs = 0.0.0.0/0 in the config file into:
AllowedIPs = 92.13.14.15/32 10.192.122.0/24

where 10.192.122.0/24 is the subnet of my tunnel, and 92.13.14.15/32 is the ip address of my home computer

this works on iOS and macos for me
You are right, as from a design perspective, Windows was based on Mac OS. What I meant was that the first versions of Windows were built on DOS:

https://www.quora.com/Is-Windows-still-based-on-DOS
Heavy weights also make an exceptional therapist.

You can tell anything you want to a 200 pound loaded barbell, over and over again...
Exercise is good for you. We've always known that. Also we know that eating properly is benificial, as your social situation and that you have a meaning in your life. Modern society rediscover this bit by bit.

My guess is that the last part, meaning, will be discovered and accepted lastly. To bad, cause that's in my opinion the most important thing.

If you believe in the evolution theory you can logically arrive at what is good for you.
one can logically arrive at what is good for one. What is right is what evolution has adapted us to. So the task then is to try to make as qualified a guess as possible and then try to match our lifestyle against it. Some things are obvious, others are more difficult.

Through evolutional history, what happend to individuals that didn't had any meaning, that did nothing that helped anyone, that was useless? Well, they died of.
I'll reply on the assumption you posted the above in good faith. The article is talking about patents, not copyright and it's important to distinguish between the two. I didn't read the article in detail, but basically it's saying that if you allow Alice to use a patent in a piece of software and you allow Alice to distribute that software to Bob, that you can't now come after Bob for using the patent in the piece of software -- because the patent has "exhausted". I'm not entirely sure this will hold up of Bob makes a derived work of the software, but I suppose it might. It's an interesting thought.

Anyway, on to your questions, which seem to have little to do with the article: "Does this mean that MongoDB and others who have changed their licenses to be 'everyone but cloud providers can do this for free' is not able to do that because the work has been presumably licensed?"

No. They can make any kind of copyright license they want. There is no exhaustion for copyright. Just because I grant Alice a license to the software doesn't mean that I have to allow Alice to give it to Bob. In fact, I can make a license that forbids Bob explicitly, but allows Cathy to get a copy. I can even write a license that disallows people who look like Bob (unless that is discrimitation in a protected category) from getting a licence from Alice.

Incidentally, I could do that with a patent as well, but the situation they are talking about is Open Source licenses. Open Source licenses are, by definition, licences that do not allow you to restrict who Alice can distribute the software to. MongoDB people would like to redefine what Open Source means, but until they do, their license is not Open Source.

Question 2: [I am building a hardware/software project that relies on Open Source software]. "Is patenting my work okay? What parts?"

You can patent any parts of your project that you want. However, some of the software included in Arduino contains a patent licence. Your software may or may not use that software. Pay attention to the license that you use for your software. If you are using a license like the GPLV3, then you are granting a patent license with the software. So this means that if the software contains patented parts, you are granting a license to the downstream user for that patent. If you don't want to do that, then don't choose that license. If you are choosing that license because you it allows you to cheaply use software that other people have written, then too bad for you. You'll have to write that software yourself. That's the price of the software: take it or leave it. It's your choice.

Now, with respect to the suggestion in the article: if you choose to write your software using an Open Source license that does not have a patent grant, will you end up essentially giving a patent grant due to patent exhaustion. Maybe. I'm not a lawyer, but it's an interesting possibility. Again, same advice: if you don't want to, then don't. But don't complain that your non-Open Source options are too expensive.
I guess that's true! I switched from writing in BASIC to writing in Z80 assembly after a year or two - though it has to be said that I "compiled" my program by hand, referring to the opcode table(s) at the back of the manual.

My resulting programs tended to look like this:

10 FOR N=60000 TO 60000 + 20
20 READ A
30 POKE N,A
40 NEXT N
50 RANDOMIZE USR 60000
100 DATA 1,2,3,4,5,....

As you can imagine it was a tedious process. Most of my time was really spent trying to hack games for extra-lives, which I guess wasn't so unusual back in the day. Later I used the same skills to patch binaries to accept serial numbers - before I started writing real code in C, Java, Perl, etc, etc.
Unfortunately we are living in the world where the common sense is wrecked. People do complain if abusive notifications are blocked and websites are rendered unusable as a result, though it is completely the fault of websites! Keep in mind that browser vendors are trying to solve multivariate equations that involve users, web developers, companies, abusers and crackers...
Apple planning to launch a new platform in this market is definitely worthy of discussion in an article about the growth of this market. The reason it’s not mentioned is the article was published before Apple’s announcement.
Vietnam is a stunningly beautiful country but unfortunately a love of nature doesn't seem to have really taken hold there. At least not yet. Missing from all the gorgeous photos of Mekong Delta waterways and pristine beaches is all the trash you'll find strewn in heaps everywhere.

My guess is it will take another generation for people there to appreciate how blessed they are to live in such surroundings but by then it will unfortunately be too late. To some extent this is just the inevitable consequence of a small but populous country hurtling into modernity but there are also some important cultural attitudes that need to change.
Interesting that the stigma is so recent, and it appears it is largely self-inflicted: I got the impression that it is mainly the women themselves who choose to hold their "failure" quiet, and not some outside moral authority (though of course societal expectations silently drive the reclusiveness response).

Fore more thinking on a very related subject, I warmly recommend this talk about the metaphysics of pregancy: https://www.youtube.com/watch?v=COZEansw_Ts
Who cares about what that guy wanted or didn't want. The question is whether we should let people distribute his manifesto for the sake of freedom of expression or if we consider it to be dangerous and worthy of a ban. The opinion of the guy who committed this heinous crime is frankly irrelevant IMO.

If I was to commit some atrocities tomorrow and write a pamphlet outlining my motive and calling for others to do the same thing while adding a note saying "look, they'll try to censor this!" will you, out of principle, argue that my manifesto shouldn't be censured because that's what I would've wanted? If so, why?
Location: Bangkok, Thailand

Remote: No

Willing to relocate: Yes (Interested in positions in London)

Technologies: React, Redux, TypeScript, Webpack, C#, Flutter

Résumé/CV: https://www.linkedin.com/in/lars-jarlvik-04756887/

Email: lars.jarlvik@gmail.com

Swedish software developer with 11+ years of experience, mainly within front end web development. Looking for senior position within a small/midsize company in the London area.
I rember my first Job (based at Cranfield Uni) and we where a long way away from the Exchange - Some times you had to whistle into the acoustic coupler to get the carrier to pickup then quickly put the hand set in.
“trash talk” is fine but I think what the former poster was referring to is the trolls. Online gaming is no different to any other online activity in that regard (or even real life playground “banter”). Ie some people are little shits and others aren’t. The trick is to give the shits a wide birth; which is often easier said than done.
Far as I can tell he's also off by a factor of 4.

Tesla 85hw battery pack 1200 lbs.

3000 kw X 4 hours = 1200 kwh.

1200kwh/85kw*1200 = 170,000 lbs.

A GE/NS Dash 8 weighs in at about 390,000lbs
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