skysight-inc/HackerNews huggingface dataset:
> The mechanism of action of analgesic drugs is very simple and well-understood.

https://academic.oup.com/bjaed/article/14/4/153/293533 (2013)

the exact mechanism of action of paracetamol [ie acetamophen] remains to be determined. There is evidence for a number of central mechanisms, including effects on prostaglandin production, and on serotonergic, opioid, nitric oxide (NO), and cannabinoid pathways, and it is likely that a combination of interrelated pathways are in fact involved.

That's the most widely-used analgesic in the world, and its mechanism is evidently neither simple nor well-understood.
Conducting a Better Technical Interview: Problems and Solutions
Hi there. No, dofo.com is a search engine for domain names. We do not do front-running, and I think nobody does this in 2019. :)
The day this comes out I hope there will be a browser extension that automatically strips the retarded DRM by copying the html from the "viewer" website and replies to the original sender with the contents, so that a "cracked" copy of the email is saved in both the sender's and recipient's history as it should have been in the first place.
It's not clear what the use case is for something like this. Why wouldn't you use an alternative communications channel like Slack in this situation? I mean, if you don't want to use email, don't use email. Why go through all the complications this introduces.
As evidenced by sweeping generalizations about "the West" and "the Rest."
Student-led CatSat mission selected by Nasa
The spinning wheels are directly connected to the stab trim via cables. If the trim motors fail, the pilots can turn those wheels by hand (there's a folding crank on them) to manually adjust the trim.
Is it never too late to pursuit a dream
The evidence is in crumbling infrastructure, poor provision of essential social investment, and increasing political and social extremism.

Short-term greed turns out to be a ridiculously naive, stupid, and short-sighted way to run an economy.
Yeah, I mean all Java ecosystem and I, personally, prefer Kotlin too.
You would argue that but you'd be wrong/out of alignment of the vast majority of the world's population.
The Super Positive Community of Competitive YouTube Water Drinkers
Because of a history of psychosis in my family I decided to never take drugs in my life, not even cannabis while I life in a country where it's legal. I still got a heavy psychotic episode last year. Turns out the (heavy) drinking I participated in my student life was to blame. Research has shown that alcohol abuse causes an 8-fold increased risk of psychotic disorders in men and a 3 fold increased risk of psychotic disorders in women. [0] Not telling this to undermine the danger of cannabis for psychosis, but I wish I knew alcohol is unresponsible too I you have a high risk for psychosis. Sleeping enough, excercise, healthy diet and not numbing my stress with any substance has greatly helped as well.

[0] https://en.m.wikipedia.org/wiki/Substance-induced_psychosis
Nvidia's Spade: Semantic Image Synthesis with Spatially-Adaptive Normalization
I don't care, I don't use either but I'm capable of ethical analysis
Operating an Android phone for the first time involves going through a wizard for setting up things like language, timezones, wifi, etc.. one more screen in that wizard does not add any frustration
Where human populations are lower, there are fewer ticks that bite humans.

Bits of woodland near cities and also with wild animals are where you should be most worried.
a 2D point is not enough to define complex numbers
About 5M bytes in size, considering that the drogon application is statically linked, I am afraid it has no advantage in binary size.
It depends on what you mean by "process."

https://variety.com/2017/digital/news/google-gmail-ads-email...
That's fine, but doing so while forbidding hiring anyone to replace you is wrong. The whole point of unions is to obtain and abuse a monopoly on the supply of labor.

That's obviously bad for employers, but it's also bad for other employees who aren't in the union, and for anyone who wants success to be based on talent and hard work instead of politics.
Error handling via exceptions and generics are things that I can't live without. Go moves in that direction, as far as I understand, generics are expected in the next versions of Go and error handling somewhat improved, so may be it'll be good enough after few years, but I just can't write current Go after Java, it's like running with chained legs.
I think it's "'delayed evaluation' + 'transparent internal structure'". So delayed evaluation isn't enough, because the only thing you can do with N closures is to call them in any order, you can't create a complex new expression dependent on the substructure of the closures.

The closest thing to a macro in (eg. python) imo looks like this.

Instead of

d = c * (a + b)
class Adder:
def __init__(self, left, right):
self.left=left
self.right = right

class Multiplier:
def __init__(self, left, right):
self.left = left
self.right = right

d = Multiplier(Adder(a, b), c)

Fill out the __call__ function and/or create an evaluator that recursively calls each class instance with it's parameters and you've made a system that works a lot like a lisp with a macros. Now you can do broadly /anything/, eg. replace every instance of an adder in the call tree with an adder+1. That's using the second required element of my description of macros- the complex substructure, to perform arbitrary transforms. You can't do that with just closures, unless they make their bound parameters accessible (and normally they don't directly, in python they do because it's absurdly dynamic). Of course this is not at compile-time, it's at "delayed execution time", but the difference is kind of slight imo. The benefit of a real lisp over doing this in python is that you don't need to rewrite every fn, operator, control flow statement into your own abstracted level by hand, and it's much faster. Also you can complete the loop and trivially write it back down into eval-able source code text.
Installing GraalVM EE 1.0.0-RC14 with Sdkman
I was providing data for your

> I doubt theres a forest in Europe that hasn't been touched by man.
They're mechanically linked on Boeing aircraft. On the 757, and I believe the rest, the mechanical link has a detent. With enough force, the pilot can move it out of the detent and move the controls independently of the copilot. The reason for this is if one side or the other is jammed, the pilot can still fly it.
>Turns out the (heavy) drinking I participated in my student life was to blame.

Did it happen during a night of heavy drinking? Because if not (and even then) I'm really not sure how you can pin it specifically on the alcohol.
DRM for email.
You'll note in that video, the left-hand pilot has a headset on, presumably the right-hand pilot does too. Headsets are seen in other videos [1] of the cockpit.

So even if the spinning trim wheels make noise, they may not have heard it.

(My google image search shows some pilots wearing two-ear headsets, some wearing one-ear headsets, some wearing two-ear headsets with side not on their ear, and some not wearing headsets. But some of those are pilots posing for photos, and presumably pilots don't let people visit the cockpit during critical stages of the flight)

[1] https://youtu.be/wz2Q3COfveg?t=409
Bounties exist, but because of the reality of development in the OSS space they're not really something you want to lean on for financial security. Pull requests frequently can take a really long time (months) to be accepted, if they're even accepted at all. The bigger projects are the worst offenders in this in my experience (sadly those are also the most likely projects to have bounties). Very large bounties (for work spanning months) paradoxically become the least attractive because of this, because if your pull request doesn't get accepted in that case you've just thrown months of work into the toilet.
I'm not from the US (born in Eastern Europe), but I'd like to share some of my own experience.

I'm 26 now and I barely finished high-school because I thought it was a waste of time and I was working on my own projects and learning everything I could on my own about CS. My last year at school (turned 18 just before the start of the school year) I found a job as a QA in a small outsourcing company and didn't even attend classes. I didn't even care it wasn't a dev job. I wanted to be around devs and see how it is to actually work in a real company.

Now the important question here is... Why would they hire me, a person that can legally work, but not having a high school diploma? There were a couple of factors that played in my favor. First - it was basically a contract for 1 year, with 3 months of trial period. I was supposed to take the place of a woman that went in maternity. Second - I wanted a laughably low salary, really low. To me it was a lot of money at that time, but I didn't know my worth. Third - I did really well on the interview and I managed to prove to the owners of the company that I can do this job.

They hired me.

I did my job well and after the trial period my boss pulled me to the side and offered me a permanent contract. I said yes without even thinking. He said that it's usually normal to ask for a raise after your trial ends and I asked for something stupid like 5%. He smiled at me and gave me a 100% raise and the position of a dev.

I got lucky. I've thought a lot about it, but I really think that luck was on my side there. I obviously did the job good, and to this day it's the company I've worked the longest for - over 3 years.

By the way I got A's on all of my final exams (had to book holiday to go and take them haha) and got my diploma. After that I decided to enroll in university, but it was just the same as in high school. After 1 semester I couldn't escape the feeling that I was wasting my time. I continued, but in the end I dropped out. I think I made a mistake enrolling in a CS course. I should've went for something that's interesting to me, but not necessarily to do as a living like Economics, Physics, Philosophy, History etc.

I like the idea of higher education and I'm still thinking about enrolling and pursuing a degree in a different field, but I wouldn't go for a CS degree again. My 8 years in the industry now have taught me everything I need to deal with it.

EDIT: Grammar, spelling
pl is a variable. So this array size is variable. What would happen if the allocation cannot be made on the stack?
I don’t understand why you are raising this here, but also arguing my same point in your other comment?

Edit: in your other comment it could be argued that all those things (robber barrons, snake oil, Nazi Germany) were good for some of the people some of the time.
Ew, the entry for The Dark Side of the Moon [0] is totally ruined by that "original master recording" label.

[0]: https://lpcover.wordpress.com/2014/04/19/the-dark-side-of-th...
In the US.

In eg the UK it's somewhat difficult to get xanax, but similar meds should only be used short term.

https://bnf.nice.org.uk/drug/alprazolam.html

> Avoid prolonged use (and abrupt withdrawal thereafter); debilitated patients (reduce dose) (in adults); elderly (reduce dose) (in adults); history of alcohol dependence or abuse; history of drug dependence or abuse; myasthenia gravis; personality disorder (within the fearful group—dependent, avoidant, obsessive-compulsive) may increase risk of dependence; respiratory disease

https://www.nice.org.uk/guidance/qs53/chapter/Quality-statem...

> NICE guidance provides recommendations on pharmacological therapies for anxiety disorders. Benzodiazepines are associated with tolerance and dependence, and antipsychotics are associated with a number of adverse effects. Therefore they should not be used routinely to treat anxiety disorders.

> Healthcare professionals should be aware of circumstances in which benzodiazepines and antipsychotics may be appropriate, such as short-term care and anxiety disorder crises.

Here's a website showing that alprazolam is not prescribed in the community:

https://openprescribing.net/analyse/#org=CCG&numIds=0401020A...
Yeah, I mistakenly thought Warsaw Pact and Soviet Union were synonyms. Oops.
Echoes of virtue our contemporary signaling social media culture. Very informative book review.
Bad decisions can be made using any technology. Java has a lot of crufty legacy APIs because, well it has a legacy. I gave up using JSPs years ago for Freemarker. I now use Vert.x rather than servlet contains which gives me a node.js environment but with access to the Java ecosystems and basic things like mature logging frameworks, as well as more advanced features (oh and multithreading in a single process).

Despite Spring being Enterprise it still scales down to simpler apps pretty well due to its modularity.

These can be build into a single jar app that is easy to build and deploy, and combined with a database migration library, maintain their own database schemas. Very, very usable.

Yes, I probably would not use Java on the frontend unless it was for a technical audience.
For blog-posts which contains technical how-to information, the comments often contain corrections or other additional information which may be relevant for later releases or other distros.

I’ve certainly found that useful more than once.
It's a kind of extortion on a national or even global scale. "Nice economy you have there. Shame if anything would happen to it."

Nassim Taleb's suggestion is to simply deny institutions the option of growing large enough that their demise would threaten the system. Once an entity gets too large to fail it should be split so that the remaining pieces can fail individually without dragging entire system with it. This would get rid of the moral hazard "heads I win, tails someone else loses".
Europe’s Second-Largest Fintech Hub, Sweden, Could Stop Using Cash by 2023
The cynic in me is worried that Google taking its ball and going home: if Chrome can't be the default, then nobody can.

I'm excited for increased choice, but Google is starting this race from a position backed by a decade of anti-competitive licensing agreements around Android. From the press release, this move seems designed to preserve that lead by preventing other vendors from offering meaningful defaults.

I'd be especially curious to hear from the Samsung Internet team, as the press release states that Google will be "asking users of existing and new Android devices" which browser they would like to use.
People –like migratory birds– might have a built in compass
Hmm, I tend to think that what one can do with some objects is an essential part of what they are.

Two-dimensional vectors can just as well be thought of as points in the plane. What sets complex numbers apart is eg that we define complex multiplication of them.

A more general example: a group is not just some set G, but that set with a binary operation satisfying certain axioms.
Watch Ajay's Interview with Kathy
That's a wild misrepresentaton of what I wrote. I was talking about what people think and say, not what they do. Actions are actionable. You can and should fight racist actions using the legal system. And if the laws aren't good enough, then let's fix them.
What's with the name? Sounds very iffy to me.
Posts like this on the subreddit don't help: https://www.reddit.com/r/VolkFi/comments/b0xpmn/volkfi_viral...
I think you're right. I misread it. My point about cost still stands.

"Cockpit displays and a warning light intended to flag problems with angle-of-attack sensors in flight were optional on the Lion Air jet that crashed, according to people familiar with the matter. The carrier, like some others, chose not to purchase the feature, people familiar with the matter said, so pilots didn’t receive any such alerts."

https://www.wsj.com/articles/maintenance-lapse-identified-as...
Gmail Introduces DRM for Email
While this may work, and would work on me if I really did love the project enough, I think the fact that a lot of companies use big, scary language like this (the most notable example is Wikipedia) means that this isn't a well-received option anymore.
Very doubtful. Where are the crises in legal states/countries?
Sure, but they've essentially decided to not make money and solve their hunger. "Some people decide not to make money with their art" is a very different statement than "you cannot make money with your art"
How do I get my browser on the list?

(And it totally is a browser and not some keylogger and bitcoin miner with a copy of lynx on top.)
He has subreddit for himself, that's weird.
From all the comments under your post I can totally be confident teraforming is an option if we ever need to get off the planet. /s (as in /sarcasm and /scared)
Yes perhaps.

From what I understand the recent vinyl resurgence is a very physical thing, possibly not a rejection of digital, but certainly trying to make up for digital's short comings. So I can't quite make sense of it in the regard. Another way of looking at it is as 'Art', but these don't seem to be artistic pieces.

Maybe I'm reading too much into it.

Its a niche about sound track albums, I'd just prefer something to pull me in, explain why I should appreciate it, not in a confrontational sense, just that I like to hear people communicating their passion for something, even if I don't see I personally.
Exactly. It just basically says, from the people who requested mental health care, more of them used cannabis than from the control group. Great. They also present higher rates of smoking, alcohol use, self harm, obesity, and various disabilities. Some may be cause, some consequence, some none of them. The title is correct, there is a link, but that link has not established causality of any kind. This is basically repeating uncountable studies saying the same thing.

CBD, present in cannabis, is known to be antipsychotic, so the self-medication hypothesis is pretty strong. It's the same case as nicotine, schizophrenics have way higher rates of smoking, only because nicotine has a mild antipsychotic effect, not because smoking turns people crazy.
Norsk Hydro Ransomware Attack Is ‘Severe’ but All Too Common
If it’s from your org, vault keeps the records, if it’s from personal or outside gmail accounts those vaults should retain records. A court order could compel the other party to provide records.

Of course this adds a complication but it’s not completely deleting the records everywhere.
In practical political terms (western and otherwise), "because freedom" is rarely a winning political tact. The legalization of cannabis was driven by cannabis being normalized. The news presenter and your daughter smoke grass.

It was similar with gay right. Marriage rights, parental rights and such were driven first by "born this way," argueing that sexuality is unchangeable. Then, it came via normalisation as people came out and your friend end turned out to be gay. Eventually people concluded that homosexuality is fine, not a vice. "I think it's wrong, but freedom" only plays a role after the gay rights side wins. The dissenters can console themselves with it and put the issue to bed.

That doesn't mean no one actually idealises freedom, but it rarely adds up to political change.
gRPC Asynchronous and Java
Glad if somebody can throw ideas/experiences on scaling grpc async using Java. Basically I need to scale grpc communication to 1000+ remote machines/grpc processes from one clien grpc process. I send parallel grpc requests to 1000+ remote grpc processes. Would like to understand different approaches which can be taken. Like should I use one thread pool for grpc requests and another to process the async responses. How do I scale it? Will I need multiple java processes for requests and response processing. Please share your thoughts and experiences with this kind of problem. Thanks.
> Think of this every time you fly Airbus.

Why? They're not falling out of the sky so the system obviously works. Stop being a fanboy.
CDS is often pitched as insurance, but the contracts aren't written that way. Instead its closer to a simple:

if company defaults: auction debt
payout = (face value - auction value)
* contract amount
Do you know why digital pulse radios never happened?
I do use Firefox as my private browser, but at work I switch between multiple browsers and various test environments. So I have lots of almost identical urls where Chrome completes something I don't want to be completed, or pretends it doesn't understand what I'm looking for.
I have literally heard this rhetoric for the 20 years I've been paying attention to this and I still haven't seen anything even approximating these grand promises. Software Development is a difficult field and expecting a big crowd to suddenly adopt it and start producing valuable content is not reasonable.
Do databases like MySQL/PostgreSQL support searching the reverse index?
I was looking for a solution but haven't really found one to show autocomplete results.
Death by Vmmap
Best book I've ever read on the root cause ("tight coupling") of accidents: https://en.wikipedia.org/wiki/Normal_Accidents
From its Wikipedia entry:
>"Normal Accidents: Living with High-Risk Technologies" is a 1984 book by Yale sociologist Charles Perrow, which provides a detailed analysis of complex systems from a sociological perspective. It was the first to "propose a framework for characterizing complex technological systems such as air traffic, marine traffic, chemical plants, dams, and especially nuclear power plants according to their riskiness." Perrow argues that multiple and unexpected failures are built into society's complex and tightly coupled systems. Such accidents are unavoidable and cannot be designed around.

His analysis also applies to anesthesia disasters, I learned the hard way during my 38 years in the O.R. Highly recommended.
Even if they didn't know about the MCAS, they still knew the plane had had an uncontrolled-dive problem from an unknown cause. How is it responsible to fly it without understanding the issue?

Boeing is still fully culpable, but the airline should have debugged the issue before using the plane again.
Specs for those having issues with the website:

Display: 6.2 inches, 1080 x 2280 pixels, 402ppi, Aspect Ratio: 19:9

Sensors: Fingerprint, Hall, Accelerometer, Gyroscope, Proximity, RGB Ambient Light Sensor, Electronic Compass, Sensor Hub

Ports: USB C, Support USB Audio, nano-SIM slot

Battery: 3700 mAh (non-removable)

Audio: Bottom-facing speaker, 3-microphone with noise cancellation, Support AANC, Dirac HD Sound®, Dirac Power Sound®

Vibration: OHaptic vibration motor

Connectivity: Volk Fi, LTE, WiFi, Bluetooth

Dimensions: 155.2 x 76.1 x 7.7 mm

Weight: 179g

Color: Midnight Black / Snow White, Anodized Aluminum & Glass

Operating System: Android

CPU: Snapdragon 845 (Octa-core, up to 2.5GHz)

GPU: Adreno 630

RAM: 4GB LPDDR4X

Storage: 64GB or 256GB UFS 2.1 2-LANE

Camera: Dual 16 x 16 MP, Auto-HDR, 4K resolution video at 30fps, 1080P resolution video at 60fps, LED Flash, Aperture: f/1.7
LENR Energy: Science or Pseudoscience?
So slowly, it seems we are going back to the primitive healer's approach where they did not had a specific drug for a specific disease, but rather they made a individual combination of drugs (and other methods) for every individuals problems.

Because, of course men and women are different so it should not be surprising that they react differently to drugs, but also men or women in itself are very different, depending on their genes obviously, but also their age, their routines, their diet etc.

So good to hear, that we are going one more step away, from the generalistic approach.
Which was a cheap way, thats why it did produced results as well, but maybe not the best results.
Except who wants to let that particular parasite poison another good thing? Certainly not the people most likely to actually work on OSS. I know I would stay away from any project that did this, even if I considered donating my time and energy to them.
ouch, you "serious" and "professional" people are so boring! It's a cute idea and respectfully presented. As long as the costume is clearly innocent you cannot fathom anybody being offended.