skysight-inc/HackerNews huggingface dataset:
Yes, less payout on rare disease drugs is less of an incentive to research them. But:

* Drug companies have profit margins of 15% on average indicating there is room.
* many recent 'orphan drugs' were not newly developed, but off-label uses registered with the FDA for a whole new patent.
* these drugs rely heavily on research done by universities through public funding. It stands to reason the public should get to benefit.
* there is something morally wrong about setting the price of drugs purely based on demand. It is essentially blackmail: pay me or die / suffer.
Does a recording of this talk exist?

Ran `go run .` and it ended with:

[...]
go: downloading github.com/mewmew/float v0.0.0-20181121163145-c0f786d7da73
go: downloading github.com/pkg/errors v0.8.0
go: downloading github.com/rickypai/natsort v0.0.0-20180124032556-f194e6bd5b0c
@$const_str = global [16 x i8] c"Hello world %d\0A\00"

declare void @printf(...)

define void @main() {
0:
%0 = add i64 30, 12
call void (...) @printf([16 x i8]* @$const_str, i64 %0)
ret void
}
0>
Not a fan of the QC-35. I find their ANC headache-inducing, and while the overall sound signature is very good, it's only because of built in DSP doing EQ. The distortion is unbearable.

Thus I use the audio-technica MSR7 at work. At home, I don't need isolation, so I enjoy sennheiser's HD600.
> But it's on the way out.

In hip and trendy companies; every company I work with (banks, insurers) are using JQuery like it is the best thing ever and never heard about React or ES5. It will live for a lot longer than Silicon Valley thinks.
Good! And now the EU should invest €50M into Jolla...
I’m not sure how to get linked into the cob building scene. But once you do you will realize there is a whole community of people who live by going from one build to another. A lot of them learned how to do it from this guy https://m.facebook.com/CobCottageCompany/

I helped a friend who wanted to build one and finally realized that dream before leaving for college in Europe by using a friends land to make it happen. Actually she was going to back out since 2-3 months isn’t really enough time to do it with a small crew and little finances but the DIY network wanted to film her for thier show and reconvinced her to do it (she submitted her idea to them at some point). Here is the link to the IMDB/Amazon video page: https://m.imdb.com/title/tt7974258/

(Note, the film crew never grabbed my signature for permission to show my face, so I didn’t end up making it past the editing room floor.)
Yes and no, the EU is more concerned with intrusion into citizen privacy from the private sector than any other large player.

As far as the public sector goes, however, the GDPR is mainly meant to increase security surrounding citizen privacy. You can’t demand to have your criminal record deleted for instance, and there is a range of privacy data like that which serves a purpose within the public sector. The EU is fine with that, and possibly more so than the US, but the EU does want to keep it safer than has previously been the case. Mostly because the European public sector didn’t meet really take these security requirements seriously enough on its own. The GDPR didn’t really change the rules for the public sector, it rather increased the penalty for not following them.

There is an old saying that in the US people trust their corporations and not their governments. It’s the opposite in Europe.
Am i wrong in thinking that 900GB barely counts as "big data"?
Important Security Implications for GitHub Actions
I completely agree with you that solving a DP problem for a job interview shows next to nothing about the candidate, that asking a DP problem as an interview problem is cargo culting/rain dancing/etc. On the other hand, I believe DP is fundamental algorithm that comes up again and again and is the equivalent in importance to the simplex method but for millennials and gen-[xyz]'ers.

Among the problems it solves are:

* Shortest path in a graph (aka Bellman-Ford's method) [1], A* path finding [2]

* Approximate string matching [3]

* Viterbi algorithm for hidden Markov models [4]

* Earley parser [5] for context free grammar parsing

* Dynamic time warping [6]

* Finding the base of a strong generating set for permutation groups [7]

I'm consistently surprised that DP crops up in so many places. While most people won't be required to implement the above list in their day-to-day programming life, it's quietly in the background as a fundamental algorithm.

Dynamic programming is one of the few algorithms that, in a "natural" way, reduces a problem that is naively exponential to one that is polynomial. For example, try counting where 2^T random walkers lands in an array starting from the middle after T time steps. Naively, this would require 'simulation' of 2^T but with DP you can do this in O(T^2) (assuming addition of atomic integer types is "free" and there's no overflow on count) using DP (by summing a 'count' of random walkers at each time step, at each bucket in the array).

[1] https://en.wikipedia.org/wiki/Bellman%E2%80%93Ford_algorithm

[2] https://en.wikipedia.org/wiki/A*_search_algorithm

[3] https://en.wikipedia.org/wiki/Approximate_string_matching

[4] https://en.wikipedia.org/wiki/Viterbi_algorithm

[5] https://en.wikipedia.org/wiki/Earley_parser

[6] https://en.wikipedia.org/wiki/Dynamic_time_warping

[7] https://en.wikipedia.org/wiki/Schreier%E2%80%93Sims_algorith...
> relatively short patents, no gaming of patents via arbitrarily small changes

This, so much. I'd add no gaming of orphan drug patents. It's through the patent system that pharmaceuticals get their pricing power.

http://sourceonhealthcare.org/orphan-drug-act-fostering-inno...
a real life big data set would be a couple of hundred terabytes of multidimensional values not 900gb of text
Unfortunately that leaves one vulnerable to the arsenal of concern trolling. The problem is that these strategies only work if your conversation partner is doing the same in good faith. (This is precisely what Arthur Brooks would have us do, someone who deserves all of our contempt, ironically.)

After all, it’s human nature to (often) entrench when faced with facts that challenge ones beliefs! And that dynamic is particularly acute when someone has chosen to believe the less-plausible-thing, the mark of conspiracy.
SpaceX is an antidote to the idea that home food delivery is great innovation. It’s a beacon to nerds everywhere. You may not be able to build a space company, but spend at least some of your time and skills doing things that are truly new.
Program and section headers are different things only because ELF makes it so, and this is a bad design.

The same mostly goes for having both physical and virtual addresses. Has there ever even existed a loader that would generate page tables according to that? There should have been one kind of address, and possibly header flags to indicate allowable MMU states.

If there is no such bug, then you can stop wasting that byte at the beginning of the string tables.
The kernel debugger, ntsd and windbg share a debugging engine, and visual studio is a different one.

At higher levels, VS is a much nicer experience. If you ever need to get down to lower levels, especially windows libraries and services, the power of the ntsd/windbg engine and its extensions make it much more useful. Knowing it also helps when you eventually need to use KD.
Find a bootcamp that has a good record for placing people into jobs, or advertises it, or has a reputation, or has aligning incentives to do so, or whatever. Your first job doesn't have to be anything glamorous, but should then allow you to get to eventually wherever you want to be in your software career. Some of these bootcamps have skill/interview requirements, so that will help direct where your home study and practice should be.

Or, you could go to college and get a master degree in CS. Colleges then have on-campus-recruiting and some set of companies that will basically hire anyone who graduates from the university with a CS masters degree. It's the same idea as the bootcamp; go somewhere with the connections/infrastructure in place to help you get your foot into the industry.

Now, once you have your choice of companies to choose from, I tend to recommend startups. That's the one place where you have the opportunity to do things that you definitely shouldn't be doing given your experience level. But, since they have so few employees and so much to do, you're it. Then with those rapidly acquired skills, and with a year or two of relevant experience now on your resume, you can more easily get a cushier, more stable job at a larger company, if you wish.
I also think that Orcas or their ancestors had a role to play in the extinction of Megladons
Story time: I was a young programmer in the 80's, working in an environment where the computers were all housed in their own special isolated computer room, and we devs had to use terminals to gain access - a typical computer ops setup, you've seen it all before.

One day, in order to comply with some law or other, the company upgraded the security system, renovating the space such that it was enclosed in bullet-proof glass panels, required a key-card to enter, had an operator at all times (24/7), etc. They installed a Halon fire suppression system, and a gigantic alarm horn to function as a company-wide alert.

Well, the day it was all set up, it was time to test it all - Halon test dump, done (very expensive test). Operator still alive (had to use an oxygen mask), done. Alarm siren test: done. Okay, back to work .. hang on .. all of the systems are down .. what's going on ..

Yes, the siren was so loud, and had been positioned close enough to the bullet-proof walls, that the focused energy it created had crashed the disks. ;)

That was a very expensive renovation. Fortunately, we got the 'restore from last backup' test done pretty quickly ..
فروش ویلای 280 متری در خزرشهر شمالی پلاک اول دریا: املاک مشاورین خزرشهر
Personal seals lose ground as big Japanese banks stop using 1800s technology
> Hillary's "deplorables" comment was the embodiment of this problem.

I'm always fascinated by the fact that some people believe this.

I remember a decade ago, in a heated time during an actual war, Sarah Palin would go on and on about "real Americans," a group which she made clear does not include me. Just one memorable example of the rhetoric she used toward those outside her tribe. She was a huge hit and hugely influential in her party.

Clinton let fly once with a comment exhibiting the same level of contempt that prominent Republicans use all the time and she suddenly became exactly half the problem.
It was designed by the IETF as an extension of the Secure Shell protocol (SSH) version 2.0 to provide secure file transfer capabilities... potentially you should check your facts.

Did you know, it is also sometimes referred to as the SSH File Transfer Protocol?

Also if you need further clarification, it might pay to check the default port for both SSH and SFTP.
The article implies that the test stand was running at a fixed frequency. This makes me suspect that this has to be designed to interfere with transmission of sound at a specific frequency, and perhaps isn't capable of eliminating more complex sounds like voices or music.
It's not, because the comparison was about brand value and brand perception. YC and Harvard have a very similar elite only-the-best-get-in-and-then-you're-set perception in their respective markets (plus a scarily similar "if you know guys who knows guys, it'll be easier to get in" aspect).
It is interesting though, because even at least in theory, you vote for your government but not the corporations.
Vue-cobra – Reading position indicator for Vuejs
Fuel them with Hydrogen/Oxygen produced from electrolysis with solar power.
Polarization is a tactic used to gain power, on both sides. It’s obvious who benefits from polarization: the moral defectives who end up in positions of power and influence by stoking it.
Being in Sweden, I'm apparently not allowed to read the full text as it require an "Extra Crunch membership", which isn't available outside a couple of countries. But as a consolation they inform me that they are "actively looking to launch" their membership in other areas. Not impressed.
https://news.ycombinator.com/item?id=19338830
I think it is more than just Privacy. Privacy concerns are just a byproduct of policies that puts individuals over corporations, people over cars, and so forth.
> This funding will without a doubt accelerate our ProtonDrive efforts...

Looks like there’s a somewhat working site to learn more: http://protondrive.com
Strange that the article doesn't mention Oncode institute [1], which has specific goals of repurposing generic and patent-expired drugs in combinations to lower costs and there were some discussions about making the drugs themselves

[1]
https://www.oncode.nl/research/programs
No he isn’t. I agree with him that there is something interesting about the fact that he refers to democrats specifically and conservatives generally. It gives us some insight into his/her bias. It exemplifies some of the broad strokes that are being painted. All conservatives think X because all conservatives, whether fiscally or socially, have the same beliefs. Their anecdata is also highly questionable and presented as a legitimate source of information.
Western Digital to Demo Dual-Actuator HDDs Next Week
My personal opinion is that MathML should die. MathJax is here today and works.
You vote with your money
have jolla approached the EU for funding?
Wow, as an EU citizen I can't figure out whether I think it's good or bad that we're now funding foreign companies.

Sure, Switzerland is very much European, but they're not in the EU. Romanian taxpayers are now contributing more to ProtonMail than Swiss taxpayers are.

This would be very much like the US government subsidizing a Canadian software company, on the grounds that 40% of their users are American plus some of their developers live in Vermont and Kentucky.

But, well, at least it goes to the good guys! So yay ProtonMail, I guess!

EDIT: I stand corrected, please do read some of the very insightful replies people posted. Thanks everyone!
The Guide to DeepLearning with Tensorflow and Keras – The Beginning
Don't work for a recruiter who doesn't know what this is?
Did you know that Oracle owns the trademark to JavaScript?
I wouldn't go as far as to say we "trust" our governments. But having privacy tools to ensure both corporations and governments stay off the path to mass data collection on their users/citizens can only be a good thing.

It's a double-sided argument however, on one hand the EU shows some interest in privacy, but member states still allow anti-privacy laws to be introduced in the name of "security" [1].

[1] https://www.laquadrature.net/censureterro/ (French)
That's also not a silver bullet see CF where foundation funded research and sold the IP to pharma company for 3.3B$ and the patients were then charged 300k a year for it.

https://philanthropynewsdigest.org/news/cystic-fibrosis-foun...
I hate essentially all of San Francisco (so I am biased), but Adam’s Point, Rockridge, Jack London, and a few other neighborhoods are ok in Oakland.

Berkeley is the really underrated place, IMO. Somehow they went from being the city with the whacko leftist government as a negative outlier, to actually being relatively sane as a city in the area. Emeryville is the only really good government in the are, though.
A very naive question, but could we rotate an asteroid apart? Suppose we continuously hit it with a laser at an angle, so the resulting heat would cause a bunch of small explosions and impart angular momentum, until it rotated so quickly that it simply tore itself apart.
Show HN: Give a new look to your App using Bubble Navigation
No, it's not easier but it's vastly more convenient and flexible. You can encrypt each dataset with different keys, and ZFS allows you to unlock them on import or whenever you want to. You can send and receive them while encrypted. Also ZFS encryption means that I can finally encrypt external HDDs that I share between Linux and FreeBSD without having to resort to ugly hacks.
Freakonomics! https://youtu.be/aFYlgqv3T-w
Or KaTex, which I believe is superior to MathJax.
Comical. No-https
Yes, in capitalism theory, where individuals are rational entities that can comprehend, afford, and consider the consequences of their choices without being swayed by advertisement or their economic situation.

In practice, people buy the best value thing for now without giving much thought or as a general rule being able to comprehend the long term impact of it on their own, let alone the society as whole.

This is why we you need and have anti-trust, consumer protection, and various other laws and systems to protect consumers.
You buy stuff from corporations everyday, at least in theory.
Citrix informed by FBI of security breach of their internal corporate network
On a New List of Categories[1] is a good entry point. I like How to Make Our Ideas Clear[2] as well, and it may be more germane to this topic. He was a prolific writer, and I've found everything of his I've read thought provoking.

Edit: Some Consequences of Four Incapacities[3] is another that deals with how we understand things.

[1]http://www.peirce.org/writings/p32.html

[2]http://www.peirce.org/writings/p119.html

[3]http://www.peirce.org/writings/p27.html
I think the distinction is artificial. I'm glad the EU is starting to fund more privacy related initiatives. For too long the only people putting funding behind tools like Signal, Tor and (our own) Umbrella App were organisations like the Open Tech Fund and other (largely US based) non-profit funders. It's important that this pool of resources has become diversified.
Extensive discussion of original source: https://news.ycombinator.com/item?id=19329330
Is there a way to use it without connecting to Twitter? I don’t have a twitter account.
From Wikipedia: The Rocketdyne division of North American Aviation was awarded the engine contract, AC Spark Plug the primary inertial guidance system, Bell Labs the backup radio guidance system, and General Electric the nose cone/reentry vehicle.

Douglas only won the contract to do the airframe and integration. It looks like a typical arrangement of the era. It’s not as if competitive bids have never been part of this process, they very often have. That’s not the point at all.
> The first innovation outside of Emacs that springs to mind is find-and-replace that lets you easily switch between literal, case-insensitive, regex, current line/selection/whole file, and current file/across multiple files.

Not sure what you mean, but from my experience, you can do all that in Emacs. They're not one feature, but a couple distinct one. Incremental find/replace with or without regex, literal, case-insensitive within a buffer is one facility, easily accessible through C-s / C-r / C-M-s / C-M-r keys (they're all for the same feature, just "s" for forwards, "r" for backwards, also press Meta for regexes), you can switch "modes" on the fly, switch to replacement mode, or even show the whole list of matches, each with a single keychord.

Incremental searches across multiple files or open buffers can be done too, though it's not something I've tried personally (I usually pawn off multi-file searches to grep / find+grep combo, which have a built-in support in Emacs, and AFAIR also a polyfill for Windows). Consult [0] for discussion.

Editing-wise, I can't think of an outside-Emacs innovation that couldn't - and wouldn't - get ported over, ending up better than in its source place because of how Emacs deep interoperability makes all features together better than the sum of them. The main convenience you're abandoning when switching from an IDE to Emacs is the lack of deep semantic features - like really smart autocomplete, or high-quality automatic refactors - but with the development and popularization of Language Server Protocol and Debug Adapter Protocol, one can hope this won't be a problem much longer.

--

[0] - https://www.reddit.com/r/emacs/comments/7tf1ln/incremental_s...
They could be more concerned, doesn't mean what they'll do will be beneficial to our privacy. In this example the money they gave to Proton was taken from others that can't invest it themselves.

Nation

Oh boy
Why is the EU investing in closed-source software? The server, mobile apps and ProtonMail Bridge are all proprietary. It's not as bad as investing in Microsoft Office but this decision doesn't make sense when they could just as easily fund fully open-source email solutions like Mail-in-a-box, iRedMail, Mailcow etc. I don't think they researched ProtonMail as thoroughly as they did the other open-source software they've invested in like 7-Zip, Apache Tomcat, Drupal, Filezilla, VLC, KeePass, Notepad++.
The EU is not a nation.
OneCoin Leaders Charged in Multibillion-Dollar Pyramid Scam
> Romanian taxpayers are now contributing more to ProtonMail than Swiss taxpayers are.

Yeah, but Romanian taxpayers can profit from it by (for example) using ProtonMail. This is only possible IF the project survives.

I find the nation state important, but to "put it back" into the Internet is a huge mistake!
I think it would be better to have bounties for cures rather than patents for drugs you have to take forever. Pay a fixed price that is easy for innovators to understand and maybe the energy will focus on what we really want.
without being swayed by advertisement or their economic situation

Are you implying that the political world is not advertising and lying all the time, and that our political choices not influenced by our economic situation ?

In practice, people buy the best value thing for now without giving much thought or as a general rule being able to comprehend the long term impact of it on their own, let alone the society as whole

The same for politics
Completely agree. The refusal of us nerds to accept that our tools can be improved and replaced is a broken record that has been playing since the dawn of programming. It reminds me of how assembly programmers rejected high level languages; even with the glaring historical repetition, we are unable to recognise our loyalty to all languages is irrational.

It’s patently obvious C/C++ is just a bad choice for many tasks, particularly where security is so important. I’ve never heard someone who works with those languages agree.

However - if you’re reading this and feeling vindicated in your particular language choice - be prepared to accept that the language you favour right now is already or will soon be in the same position. That’s progress. Even if you love Haskell or Rust or Scala or Ocaml, if you think it’s anything but a stepping stone in language development then you’re just as wrong as those defending C/C++. As far as programming languages are concerned, we still don’t know what we’re doing.

If you have managed to be open minded about languages, then test yourself further by telling yourself that emacs/vim is a local optima and will be superseded by better programming tools, and you should be exploring IDEs and imagining what a world than doesn’t code in plain text could look like. Because typing coding in text form is almost certainly not the best way to write programs, any more than assembler was.

Hard to accept, ain’t it?
Thanks for sharing https://cv.me it looks super neat.

Totally agreed about HR being used to the PDF version. That's why I had to find a way to convert my markdown file in PDF. There are many ways to do it, but I would like to share two, which worked best for me.

- https://gitprint.com/
- https://github.com/alanshaw/markdown-pdf

At the end of the day, I chose `markdown-pdf` and that's how it looks https://iamskok.github.io/react-resume/vladimir-skok.pdf
You might be being downvoted because you've confused frequency with amplitude. Bass means low frequency / long wavelength. It doesn't say anything about amplitude / pressure.
There are non polluting ways of farming vegetables, and mono crop planting could be substituted with multi crop planting.