skysight-inc/HackerNews huggingface dataset:
Analyses like that are misleading because most of the industry's revenues and profits are concentrated with a few firms. The vast majority of biotech and pharma companies are not profitable and never aim to become profitable -- rather they just do r&d and then sell drugs to big pharma once some of the clinical risk is taken out

In 2018 only like 12% of new FDA approved drugs were developed by big pharma. 63% were developed by small companies. A negligible amount were discovered by universities alone

Pharma acquired these drugs from startups through M&A which doesn't show up in profit and loss statements. It shows up on the balance sheet

That $84B r&d figure seems very low. The top 15 pharma companies spend something like $75B a year in r&d. VC backed startups spend like $10-15B. Then all the firms in between account for the majority of spending. Don't remember the source but I think total global pharma r&d is like $200B
Not at the point when what makes a nation has effectively been destroyed. I'd say, with mixed feelings, Russia still had a chance until ~2005, after that simply too many of the few worthy people Russia had left gave up and immigrated away.

> At some point Russian people have to stand up for themselves.

Very few will ever stand for themselves, and much less for others. It's hard to shed blood and stand for ingrate whining pissants, when you know that the next day they will vote in a new Putin.

I have no solution to ~85% of Russian electorate simply voting for a man promising more free sausages.

Russia is irreformable. Only the most dramatic events will change that.
The comment I replied supportively to was from a person whose disability involved their hearing.

Given the context of the article, that the ensuing discussion was about autism should come as little surprise, but my initial comment was completely neutral as to the nature of the disability, beyond its visibility.

As such, it might, if one were inclined to read it with its author's intent, constitute a notable data point, given your perception of "an inability to feel a similar level empathy toward people who have different problems".
RSAConference 2019 is missing Adi Shamir, who was unable to secure a US visa
https://news.ycombinator.com/item?id=19316737
https://news.ycombinator.com/item?id=19313698
I've lived in Paris for two years and before that I was in the suburbs and I've never heard (or seen) that street. Funny how bubbles work.
In the ends its about how you feel, your well being. Right?
> rule of law in western society is well respected. This is an illusion...

Extraordinary claims need extraordinary evidence.

Most disputes in western society is handled very adequately by law. Some cases where monied interests somehow slips thru, or cases of bribery. But a majority of the time, it's treated as a vile crime.

Unlike in countries where in order to do business, you have to establish "quanxi" (social connections), or outright pay protection money (ala places like Venezuela).

The fact that a big deal is made by the media when a bribery scandal happens in western society attests to this fact.
No I guess not. My mistake:

If the input is completely separate, then it makes sense to call it 1000 different NNs.

If the input is not completely separate, then the architure I described with a high percentage of dropout in the first layer seems like a reasonable description?

This doesn't address my quarrel with the theory though; Why would that be either superior performance wise or more biologically realistic?
And the "never in the history of online discourse" bit was hyperbole. But I'm not surprised if that was missed, all things considered.
A european, gym-free version of the naked cowboy in NY.
Python continues to introduce more non-intuitive semantics that may be a small boon to the the expert class of programmers, but comes at the expense of ease of adoption for beginners. It started by making everything a generator, which are not very easy to master, and for which there were plenty of perfectly good substitutes (e.g., xrange, iteritems). And now you "add" sets of items (which you can't do in math) and when the update function worked well.

Python 3 is such a sad mess.
Rue Cremieux doesn't have an Instagram problem: rue Cremieux chose to be unique, and preserve that uniqueness. The popularity is deserved, and I think this "Instagram problem" story is part of the marketing around it.

Everything that stands out, that is remarquable, attracts attention and curiosity, that's what to expect. If you don't want that, don't make yourself stand out.
Well, as the linked post says in the first paragraph, almost 90% of the 554 new characters aren’t emoji, and include four new scripts (used by several different languages) and additions for several other scripts. Emoji are only mentioned once in the first half of the article, and unless you consider accessibility-related emoji to be only for a “fringe diversity group”, I’m not sure how the newly added emoji [0] could be particularly controversial?

[0] http://www.unicode.org/emoji/charts/emoji-released.html
I would build a big wall around it and get the Instagrammers to pay for it.
True. Process patent. But those are harder to defend in litigation, as I recall.
Facebook’s anti-vax problem intensified in Congressional testimony
Yeah, my mouse was hovering over the download button eager to test it out when my brain suddenly went "wait, don't do that!"

If you wanna run this thing, you should probably build it from source yourself (don't trust the binaries) and even then run it in a pretty well sandboxed virtual machine. I would not be surprised at all if the NSA left some surprises in that thing.
Opinion here in the Netherlands is divided between a preference for permanent winter time, permanent summer time, or keep changing the clocks twice a year¹.

Sunrise at 10:00 in the winter? Fine! That at least gives us some light in the afternoon.

1: https://www.nrc.nl/nieuws/2018/12/19/meeste-nederlanders-wil...
Later, in response to a question whether he has actually seen any photos of other people he says:

No, just their accounts are listed. I am not able to see any photos - not even my own.
Well, I would apply if they allowed non-US citizens to do so.

I have no ties to this shitty post-Soviet country, just let me apply for god's sake.
> despite no one affected by it wanting it

Falsified. I'm affected by it, and I want it, and I certainly know students who do too (Assuming I have correctly identified a Danish compatriot here).
Weight is important for a handheld device. 1mm thicker would add a significant chunk of weight.

The issue wasn't as much capacity, as it was peak power draw. While somewhat related to capacity, 10-20% larger battery would not have made much of a difference. They could have crippled the performance and lowering the peak power draw, but that was what they did when it was necessary.
I actually went into this post fully expecting to make the same snarky comment, but upon actually reading the article, they added 554 characters and 4 new scripts, along with stuff like Egyptian hieroglyph formatting support, vs. 61 emojis. Which made the idea of snarking about how they only cared about emojis look rather silly.

Anyway, since you asked, the fringe diversity group getting the new custom emojis is disabled people (mainly hearing-impaired, vision-impaired, and wheelchair users). So, y'know, on the order of 10% of the population. Very fringe.
The difference is because + in Python is intended to be a reflexive, declarative operator while += is a directional, imperative operator.

If the + has heterogeneous operands, there should be a promotion process to the most specific type that generalizes the operand types so that the addition works the same regardless of order, as exists for numeric types. But for general types (and collections particularly) the concept of most specific generalized type including two other collection types is not always sensible, so requiring homogenous operands makes more sense.

With += there is no intended symmetry between operands, the left side is the receiver into which the right side is added.
TIL - to what extent does Mozilla still sponsor rust? Looking at the governance docs[0], there's no mention of Mozilla anywhere at all. This taken with the fact there are less than 10 people in a hundred from mozilla makes it pretty clear that rust has come a long way from being a mozilla research project (which I guess should have been obvious to me as well).

What is the extent of support from mozilla? I can't find a list of other corporate sponsors?

[0]: https://www.rust-lang.org/governance
> We have a lot of data that explicitly shows that automated unit-testing doesn’t work.

At best you have data that shows that a poor unit testing implementation failed to deliver. A bad experience doesn't prove a whole tech strategy doesn't work when the whole world shows otherwise.
Misinformation about drugs causes death. Yes that is serious.
I know a guy who suicided after getting an engineering degree.

Stay away from calculus, kids.
Seeing his face carved is one of the highlights of visiting Neues Museum in Berlin (as well as his wife, obviously). He is indeed an intriguing person, who is also the subject for a rather wonderful eponymous opera by Philip Glass.
The costs may be inflated but the actual costs are probably not that different than tufts. Several other studies suggest pharma is getting a return on its r&d investment of under 5% (a Deloitte and McKinsey study as well as a Novartis one). Pharma is also cutting internal r&d because they can't get a return. They buy drugs from startups instead which does not show up in the profit and loss statements

In 2018 only like 12% of new FDA approved drugs were developed by big pharma. 63% were developed by small companies. A negligible amount / zero were developed by universities

The $161M figure cited in that nytimes study is not at all representative because most early stage r&d is done outside of big pharma, and then big pharma buys the drugs and markets them

If drug research was profitable pharma would be doing more of it, not less
Nah, GP talked about thieves who have a possesion of $100M and more, Cyprus is out of competition for them. It is one of target countries for upper-mid class to move out and start business in more civilized environment but cheaper than in western Europe.
Born and raised in Paris, lived there all my life, and never been in that street nor did i know about it either.

But that’s not so surprising. Local people usually don’t explore as much as tourists. They have their daily routines and eventually go to places for a reason. I actually often ask a non french friend of mine to bring me to new places because she still kept that explorer mentality. She knows Paris better than i do in some ways.
That is interesting to hear, I grew up in the alps, where water plays an important role in my province (90% of the enery comes from water). You can drink the water from the lakes etc.

The idea not to perfectly clean the sewage water you created, would sound irresponsible to anybody living here, as the water cycle becomes very apparent even to the craziest right wing nut when you live in the mountains.
I FEEL BAD FOR YOU TIME LIB MAINTAINERS
You can name loop labels like this, but you cannot use them to introduce actual lifetimes, that’s right.
It is a shame that the majority of these won't been seen by common devices. Google has stopped work on their Noto fonts initiative, and modern versions of Android are stuck with pre Unicode 10.

Apple has been pretty good at adding Emoji on iOS, but macOS seems to be left behind.

As for Linux... Installing the Unifont gives coverage, but most distros don't seem to have a way to update base level fonts.

I'd love to be proved wrong about any of this. But is seems that the majority of systems don't care because their native scripts are already supported.
> Although planes don't have wings

I take your point that planes don't fly by flapping like birds, but obviously they do actually have wings.
>The NYT is right; 'exponentially' is widely misused.

Not really, since both the intended and conceived meaning is "increasingly more", "a hella lot" -- and has nothing to do with exponents.

So it's a successful use of language, Wittgenstein-style. Of the dictionary definition, one is the standard mathematical one, but another pertains to the casual use: "rising or expanding at a steady and usually rapid rate". And there's an even more casual element of actual use of the word, that the dictionary is a few years behind in reflecting.
> With += there is no intended symmetry between operands, the left side is the receiver into which the right side is added.

I'm not sure I buy that, consider

a += b
versus
b += a

For integers, the result will be the same, it will just be placed in a different place. For lists, there are differences, but lists are more clearly directional in themselves. For dictionaries, the results can be entirely different.
Clean energy cost is still going down rapidly and is already cheaper than coal and other fossil fuels. Existing desalination approaches will get progressively cheaper as well simply because of energy price reductions. IMHO, solving cheap, plentiful, clean energy solves a lot of problems as most other problems boil down to being energy problems as well. E.g. food production is bottlenecked on water. Solve cheap energy, you get clean water as well. Solve that, and food production becomes cheaper as well. The water crisis is an energy crisis.

I do agree we need to be smarter how we use the land and water. E.g. California draining its natural resources to provide cheap water in LA is not sustainable. There's no excuse for that city to not have extensive desalination as its primary means of supplying water; other places in the world are managing just fine. That 25$ cost is basically about not factoring in the true cost of destroying natural resources. Also, farming practices in California are kind of wasteful and result in lots of water being wasted.
Could be! Permanent summer time has my preference but I honestly don't mind at all if I have light when I get up, but a lot of people seem to want that.

Also: permanent darkness rush hours. Nice.
Are these accusations of hypocrisy and lack of empathy directed at rosser specifically? Or are you complaining about the general sentiment on HN? Or are you complaining about something in your imagination (since you mentioned it)?

The reason people use terms like “emotional labor” is because it’s a label for an important concept that doesn’t have other terms. It allows us to get a qualitative grasp of why, for example, different policies can affect metrics like productivity and turnover for different groups of workers.

The term “SJW” is not much more than a pejorative. It’s not very useful otherwise.
The Document Foundation (LibreOffice) | Administrative Assistant | Remote only | Part to full-time | German and English required

The Document Foundation is the home of the LibreOffice community and one of the most popular open source projects, with an estimated user base of 200 million people worldwide.

The foundation has existed for seven years and today several activities are coordinated by a multi-national team of open source advocates who look after release management, infrastructure, marketing, quality assurance, mentoring, documentation, user experience and design.

We are now looking for an Administrative Assistant. The position requires speaking both German and English (which is and remains the project’s main language) and this is the reason why the tender is in German. Find it here:

https://blog.documentfoundation.org/blog/2019/03/01/tdf-tend...
It's pretty much up to individual states.
Live Chat Benefits You Need to Know
Mozilla pays for those people to work on Rust full time; they hire individuals for short-term contracts for specific work; they pay the CI and hosting bills. They also provide legal support.

Some other companies do sponsor work at times as well. A recent hot topic of discussion is “does a Rust foundation make sense”, there are good arguments for and against. We’ll see.

Oh, and note that that number is people who are decision makers in the project; about 120~150 distinct people contribute to each six-week release. We’ve had 2786 distinct people contribute. And that’s only to rust-lang/rust; not Cargo, not any of the libraries the team maintains, not any of the other kinds of work that doesn’t produce a commit.
Home Remedies for Dry Itchy and Skin on Face
"Extraordinary claims need extraordinary evidence."

And where is your evidence to your controversial and extraordinary statements?
FWIW, Atollic was bought by ST [0], that IDE is now free, including professional features [1].

[0] https://www.electronicsweekly.com/news/business/st-buys-2017...

[1] https://atollic.com/truestudio/
Why is I simpler???

You need to go to the post office, when does it open, 9, or 10? Did the lunch break change as well?

Was it the bank that changes hours on the first Monday of October or the school?

BrandX have announced they're changing their switch over date to the 3rd Wednesday of September, better add that to the diary.

Oh no I'm supposed to be starting work an hour earlier, but schools don't change till next week, what do I do with the kids.

Or

I get the first bus of the morning into work, but the bus timetable changes after the work timetable so I can't get into work on time for a week.

I can deal with different opening times, I can't easily deal with the inconsistency of all the opening times changing at different points for a month, twice a year.
Literally has been metaphorical too since before the Civil war. From the dictionary.com:

"in effect; in substance; very nearly; virtually:
I literally died when she walked out on stage in that costume."
"Imagine that some major player did begin to act badly. This would enable a competitor to offer a distinct value. "

You need to go ahead and look up 'Monopoly' on Wikipedia. [1]

[1] https://en.wikipedia.org/wiki/Monopoly
I've lived 8 years 200m away, never heard of it before.
It's a decent analogy, but not a great one. Most people grow up in a fairly similar way. Every civilisation develops differently. Also, it's clear where one person ends and the next person begins. With civilisations, that's not so clear.
Reminds me of Scala Maps[0].

Edit: after reading more carefully,...

> Analogously with list addition, the operator version is more restrictive, and requires that both arguments are dicts, while the augmented assignment version allows anything the update method allows, such as iterables of key/value pairs.

But why? Consistency in API behavior is important, and as a user I don't want to have to read that I can add lists of pairs only with assignments. I hope the draft gets fixed.

[0]: https://docs.scala-lang.org/overviews/collections/maps.html
At least UTC would be better than Swatch .beat time: https://en.wikipedia.org/wiki/Swatch_Internet_Time
The ear itself produces some harmonic distortion, at moderate levels. I don't know if that's important enough to play a role in our pitch perception though.
All these pundits don't understand that language is its use (as any linguist could tell, and dictionaries try to reflect, e.g. covering "literally" as meaning "virtually", "nearly" too).

Language it's not the etymology of the words, or some canonical meaning set in stone.

You can still make an error: it's when your use of a word is not a widely understood use (and thus you fail to communicate what you meant) -- not when your use doesn't match the etymology.

http://existentialcomics.com/comic/268
If you go where everyone else is going, and the "top 10 places to visit in <X area>", then sure. But I'd wager most places still have interesting things if you head away from where most tourists go, or simply visit a close by city instead if it's a -really- famous tourist destination like Rome.

No remote trip to Asia is necessary, unless you want to go there!
Styled-media-helper: easy media queries with styled components
Goldman Sachs relaxes dress code for all employees
I don't like the idea, because a + b should produce new list c without modification of both. Which is not memory optimal and cost of it is not obvious. Also dict is used a lot for sub classes and that could break a lot of existing functionality with potentially no benefit for most of the developers. I don't think that merging is very common operation for dicts and even so it could be done with 1 or 2 update function calls, but that will be obvious in that case, while '+' in deeps of duck typing code is not. Also absence of '+' operation for dicts is kind of guard for type validation in case if someone passed dict instead of integer. Which is pretty common when you parse some JSON from client.
It's also a problem for software engineers in the UK, for whom 6 months of the year utc and local time are the same, resulting in people not knowing the difference. In the rest of the world it's bleedin obvious.

A downside to inventing time I guess ;)
I don't think I've encountered this smooth bulbous figure art in any other dynasty, or even under any other pharaoh. And while to some this may feel like still fairly similar to all other Ancient Egyptian art, it must be noted that concepts of trends in art or fashion were basically absent until the Ancient Greeks, a seafaring & trading nation. It reminds me more of ancient predynastic figurines so, combined with sun-monotheism, it all looks a bit like a "back to the roots" kinda thing.

This was a really huge departure from tradition in almost all the ways.

(It's so fun to speculate about all this.)
85% of market (by assets) is controlled by government owned banks. There is only one large private bank in Russia after collapse of so-called Moscow Bank Ring (4 pretty big banks were basically frauding the regulator with holding other's stocks as reported assets, one went bakrupt - all others did).
> The number of seats in the EP is proportional to the population

Not quite, larger countries have fewer MEPs per capita[0][1]

[0] https://en.wikipedia.org/wiki/Apportionment_in_the_European_...
[1] https://en.wikipedia.org/wiki/Degressive_proportionality
I'll Let Myself In: Tactics of Physical Pen Testers [video]
What? No.

It's regulatory capture for the carriers, definitely not for content providers.

Whatever profit Netflix makes, it will be eaten up by the carrier oligarchy.

Moreover, with value chain consolidation like AT&T owning Hulu and things like that, we'll see carriers preferring some sites over others. Creating serious market inefficiencies.

Will you be happy when Netflix in your county is slow because they don't pay the extra tax, but crappy Hulu is cheap because it's being subsidized by their parent company?

Almost all roads are public roads.

Most electricity transmission lines are now owned by a highly regulated entity, separate from production.

For the same reason we have NN.

Edit: FYI Netflix and Reed Hastings are ardent supporters of Net Neutrality, which is evidence of 'what's good for their business'
Bob's mods and Angel's mods, of course !

That's your google keywords, there are modpacks but I don't remember the names. They are useful because the configuration is important though.

I don't recommend going the Seablock way right away.
Well, there's zero to none tension in the society if we're being realistic.
Tesla wasn’t wrong about automating Model 3 assembly line-just ahead of its time