skysight-inc/HackerNews huggingface dataset:
It's actually the opposite: If you are building an infrastructure company, you are far better off chasing startups than large enterprise companies. Microsoft just has an overwhelming advantage for them in the cloud: The fact that they are already using their services outside the cloud.

I don't know if you've ever tried to sell something, but selling to startups is relatively easy: They are starting from almost zero, so making changes and trying new things is cheap. When selling to enterprise can be a one or two year process, you can get a startup to sign up in an hour.. and that's if they don't just discover your product and sign up without sales!

But the real kicker here is that if your product bills more to larger companies for good reasons (like, say, you bill by the server, or by the transactions they process), then their growth is your growth, without needing more sales. Fortune 500 companies that aren't cloud providers themselves aren't going to grow fast at all. And while some startups fail, the ones that don't make up for that loss: You get a lot of baseline growth without having to grow your sales team. And if you do catch a future unicorn or two, you will then get to understand large company needs from an existing company, instead of having to waddle through complicated sales processes.

Amazon didn't start selling their cloud offering to Fortune 500 companies either: Those came around many years later, and in practice rely on hiring people that are familiar with the technology. Unless you have some sales gimmick that works really well with large companies (and nowadays, neither Google or IBM have one), getting startups, and a wide array of individuals that get practice on their offerings for free on their spare time, is the best way to go, and it's not even close.
In the US, maybe contractor/body shops are rarer around dev work? Mostly around the Department of Defense.

My point was that employers' ability to pull in lots of short term employees weakens their negotiating power. At least in Germany.
I took this one ages ago, before I started programming (in prep for a bootcamp) and really enjoyed it.
Even Endowments Not Beating Vanguard….So What Good Are Those High Fee Providers?
Good Enough: The Enemy of Innovation
I'll say this - a less than 100 year timeline is probably not long enough to evaluate this.

That said, I think it's possible, but I'm very skeptical that eliminating a species will be free of indirect effects.
"The four structures of AmpC determined with the new docking hits are available from the PDB with accession numbers 6DPZ, 6DPY, 6DPX and 6DPT."

Are we in a situation now where, if I have a bad anti-botic resistant infection I can just order these molecules on the off chance that they will help me?

Can I order a toxin?

Or are these molecules just impractical to use outside of a lab setting
Thanks for the article! Unfortunately I don’t think Medium is an “open” platform, there are paywalls there too.

The other thing I think we need to be careful about is having a “federated” source for the paywalls. To me, this is a scary idea. Unless the solution is open source and completely encrypted, it will just give whichever companies that do it more access to your data, on what you read, when you read it, and what you pay for.
I see that coinbase seems to be pushing the 0x/ETH as the solution, and maybe I just don't understand how the 2 are supposed to work, but it seems clunky to me. By that I mean I can't abstract the concept easily based on things I have read...
Is cyber libel really the official charge? Why would you have to specify cyber? I makes as much sence as being charged with acoustic or offset libel to me.
Don’t you think the inherent design — “microblogging” — encourages a toxic environment? Most people aren’t poets or great writers, so I just frequently see people talking past each other or misreading what has been said because there is zero nuance.
Maybe he did think of the ECHR. While it is not strictly part of the EU, being in the EU means you are under ECHR jurisprudence.

Anyway it was the ECJ which shut down similar UK surveillance laws in the past, and I remember getting rid of its "interference" being one of the arguments in favour of the Brexit.
Visualizing the Air Quality with Lambda Functions
Good points, just a small correction: Password Hashing Competition was arranged not by NIST, but by Jean-Philippe Aumasson (but we had a cryptographer from NIST on the panel).
Maybe they are using an iphone or something. Adblockers don't resolve the root of the problem!
I prefer 4chan's system with automatic reply linking. The issue with Reddit and HN is they model conversation as a tree, but real written conversation between several people is usually a DAG with one person replying to several posts at once. The UI can definitely be improved, but trees ain't it.
2018 does seem to be the year when hatred for men (or perhaps especially white men) was completely normalized.

In any case, the only winning move is to not play.
We had a MV/8000 at college, and it was a really nice machine. We had compilers for Pascal, C, COBOL, and oddly enough, Ada. You could cross-link these languages, so you'd have a front end written in COBOL that would make use of a Pascal back end. And the bindings just worked.

You knew when an Ada compilation job had been started because the other terminals would start getting sluggish...
Interesting thought - I'm not sure. My guess is it's a combination of

- increasing publicity of the propaganda (which I guess is a bit like your comment that it legitimises the claims) - if the propaganda is not already in the open, how does the government target the "debunking" without increasing exposure

- whether debunking the propaganda would have the desired effect anyway - "confirmation bias" causes people who evidence against a position to reinforce that position in their minds?
No one is training the junior devs, which is why GDC, Gamasutra, etc have been discussing the same topics on repeat for a decade or more.

The games industry's hive amnesia makes it a great place for sadistic and plain bad managers to make a nice career.

After ten years in that industry the only thing I would teach junior devs is to massively distrust any words from management. Learn how to say no to your employer and once they catch on that they can't manipulate you, get a job in another industry.
I think this could be a good example of the theory. I'm afraid that your partner believing you have done something is a bit unlucky! But you should ask her what she is doing in the dream when you are doing something bad to them. If she is repressing her response to you in the dream, I am suggesting it is likely that she is repressing this emotion in waking life too.
http://shop.oreilly.com/product/9780128007617.do
That was my first impression, but the guy has a history of saying the right things but no real action follows.

It begins to become a bit hollow, like Zuckerberg saying they’ve made mistakes and need to do better.
Redux-Persist: How to Change the Structure of Your Persisted Store
You are right. The first thing I thought about when see the headline was Rukmini Callimachi (@rcallimachi). It will literally be impossible for people like her to work in the UK. I can see this dramatically affecting the kind of reporting the BBC/Guardian etc is able to do, unless they are able to get exemptions or just ignore the law and risk the consequences.
I Quit My Software Project to Get Healthy
Why we've created TSL: a new way to query your Time Series data
Hiring Full-Stack Engineer – Python, MySQL – Remote
Investing is not a charity. I put my money where I think it will get the best rate or return. Business is business.
The Fight for Justice Takes Its Toll on Ferguson Activists
I too have experienced this. These days my self confidence is much higher. But I think the mechanism is different. I would say I encounter similar situations, but it is my conscious mind which determines how I respond. The unconscious creates the scenario, and you react to it naturally.
Qt isn't good enough for you? These days it's even scriptable with JavaScript.
Usenet did that long before reddit came around.
While I find SQL useful too, there are other things I value even more than my SQL skills.

Being able to use a POSIX Shell with tools like curl is certainly one of them as it enables me to connect different technologies on a very practical level.

Furthermore, understanding the basic functional programming principles is invaluable if you want to build clean algorithms (doesn't matter if you use Excel, C or Lisp).
Romance-related online scams cost Americans $143M last year
The ECJ can overrule an existing law, it cannot stop it from being approved. They have shut down similar laws in the past. This time I guess the UK government estimates they'll be out of the EU before the ECJ can do anything about it.
Is the domain name a play on GoMembers?
Not at all. It is there because AWS's S3 became the defacto solution for storage and because they were first AND also because of popularity and how well it works.

Your Oracle example is flawed for many reasons. SQL standard pre-dates Oracle and I am not even sure what you mean by every RDBMS client got written in Oracle's wire protocol. Ingres also predates Oracle. Are you implying that S3 API is there because they were the first? Nothing else?

https://en.wikipedia.org/wiki/Ingres_(database)#Early_histor...

SQL standard:

Developer ISO/IEC
First appeared 1974; 45 years ago

Oracle first release:
Oracle v2 2.3 1979

And also, it is allowed and trivial to implement S3 APIs because it is well documented and available for anybody. You are also implying that S3 API is not a "properly abstracted storage layer"?
GraphQL costs a lot more to do, but also gives you a lot more.

Just some benefits we've seen:

- Automatic codegen in the client removes a lot of boilerplate.

- Verification of schemas in CI makes sure we don't "go backwards" on the API inadvertently.

- Documentation tooling that makes it easy to show API structure.

- Easy to generate schemas automatically from underlying data models in the backend service (database tables, ORM models, enums, etc).

- Great type safety compared to JSON over HTTP.
> You don't even know what I'm referring to because Google's results don't mention it.

I'm well aware of both stories you highlighted.

Both are far less important than the current policy proposals of a presidential contender, so I argue Google is correct not to highlight them as the top couple of stories about Harris if you search for her.
They only determined whether those specific molecules bind to the target. They didn't test if they are toxic, if they are able to actually get to the target, how stable they are under real conditions, into which metabolites they are processed in humans, ...

This is the very first step towards developing potential drugs, it's very, very far from an actual drug. And drug development wasn't the goal of this paper anyway.

And the idea behind this paper was to find molecules that aren't in any catalogue, so you would still have to synthesize them yourself or pay someone to do a custom synthesis for you.
I think that email service was always a 1.5 person operation so something like this was probably bound to happen. Running a complicated service like email is hard and with the growing complexities of attacks, it's only going to get harder.
Of course not, but it seems to be an inherent attribute of all politicians of all mainstream persuasions these days. So other than spoiling one's ballot, what to do?
That’s what people would’ve felt about floppys. I can say I don’t really care about the removal of headphone jack. But I’m not assuming most people feel that way.
I FOUND IT!
It was called Techno Trade
street view was only good back to 2008 and it was already something else but a search on the address came up with: https://www.yelp.co.uk/biz/techno-trade-fareham
There are performance features that are impractical to deploy unencrypted, so browsers only enable them on HTTPS. (Notably: HTTP/2 and Brotli.)

There are plenty of middlebox devices on the Internet that will drop your traffic if you send anything HTTP over them that they don't understand. So you're kinda "locked in" in not deploying new protocol features. Encryption provides a way out of this.
Not one of the better design decisions, but then again, who anticipated it would become civil-oriented and thoroughly ubiquitous? My ancient Garmin handheld survived the last rollover but not without consequences: After the rollover it couldn't fast power up anymore and needed to grab the entire almanac to find itself again. Not an issue suction cupped to the yoke of a Warrior but inconvenient everywhere else.
Yeah no, I don't buy that sorry. If a company tries to automate a good SWE's job to save $100k they are just digging their graves. What easily definable parts are there in SWE? From my point of view, the only reason USA tech industry is so much better than EU tech industry is because US companies realized the success of a company is strongly linked to its product's quality which can only be made by hiring better, more educated and more experienced engineers. Going back and trying to reduce engineering cost is backwards and no one will be able to survive like that in this competitive industry.
I really don't think you can avoid spam. At the end of the day, there are only so many phone numbers, and it's trivial to enumerate them to find those that are live. Spammers can simply cycle through lists.

Now if you're worried about more "targeted" spam, I would probably say do not pick the "business phone" option.
Note that the ECHR is not part of the EU, and so a "hard Brexit" doesn't have any direct effect on our membership of the Council of Europe and responsibility to live up to our treaty obligations.

Leaving the EU does clear an obstacle to leaving the Council of Europe, but it would likewise clear an obstacle to leaving any number of other international organisations, membership of which is mandatory or implicit for EU nations.

Theresa May would indeed like to leave the European Council because she doesn't support Human Rights. Right now she isn't even able to get her own party to stop voting against her, so I suspect that it's premature to say "we'll soon no longer have the ECHR".
> The industry would be happy to pay us all 70k a year with 3% raises based on seniority

Why do you assume that's what is going to happen alongside unionization?
Read without paywall: https://outline.com/Wj3fTS
>Twitter is rapid fire updates about some developing situation.

This is the only thing i've ever used Twitter for. It's the best place to find out about problems on my local transit system. Long before the company ever gives an alert, there'll dozens of people tweeting angrily about the problems.
Can you cite some examples of people being prosecuted for saying things on twitter that aren't, you know, bomb threats or holocaust denial etc.
I was never under the impression that conversation was a thing Twitter was supposed to do. It is more like a blog than a chat client.

I don't think anyone would complain that making blog updates in Slack via pinned messages is difficult.
are they talking about private conversations in public?
The EHCR is not part of the EU, it's part of the Council of Europe which is unaffected by Brexit.

Trivium: the EU stole the CofE's forty-year-old flag when they needed an emblem.
Twitter can and could be a lot of things, and it certainly is no longer the thing it was when it started. It’s mostly why I rarely use it anymore. As a microblogging tool, I think it was great. At a conference? “Heading down to $BAR_AND_GRILL with John.” “Finally! Sunshine in Seattle today.”

But at some point it turned into what I consider the cesspool it is today. Yelling at the wind. Building my “personal brand”. A lot of sound and fury signifying nothing. But mainly a low signal-noise ratio, just not worth my attention. Maybe it’s what some signed up for, but it’s not what I signed up for ten or so years ago. And perhaps because Twitter itself can’t seem to figure out what it wants to be, it turns into something a lot of others didn’t signed up for, either.

What do I know, I don’t use it much anymore. But perhaps if they had a better defined mission, and a more narrow view, they’d keep the smaller number of users they end up with. But I guess when you’re building with other people’s money, the mission is “MOAR USERS!”
Amazon opens up Alexa store for anyone to create and publish custom skills
Significantly, though, the UK is not leaving the Council of Europe, so the ECHR will continue to apply. The usual suspect object to the ECHR for the usual suspect reasons, but the fact is that membership of it is a requirement for most forms of security co-operation in Europe. So there's no good case for leaving it.

Doesn't mean we won't one of these days.
[random comment from the internet]

"You'll want our enterprise plan, an 18 month contract at $32,000/month."

Asking for money is how you turn leads into customers. You can't compete with free. If the answer to "what would you pay for X?" is $0, the person will never be a customer. Getting paid is what makes a business relationship a business relationship. It's not about never hearing "I thought you were a cool dude."

Is $32k/month too much? Who the hell knows? Not if it's what you need to have a stable business with two full time engineers able to build features for "enterprise plan" customers. Not if it adds 3x $32k for the customer.

Look, you're not "happy to build" the requested feature. It's hard work. That's why you're asking for money. When you ask for money, it has to be enough to make the work worth while. $32/month isn't sustainable. One engineer can't build a custom feature for each of 100 clients every month unless it just involves changing some CSS. Let alone 500 clients to get to the $16k a month level. Again, anyone who is put off by your asking for money, won't be a customer. There are a lot of people who think $1.99 for an app is highway robbery.

Good luck.
I find it mostly resentment. And maybe it was always there, just now being expressed openly.
I still don’t think it’s O(1) in the limit. Why not just store pointers to the data, or one indirection if the data can be moved?
"Thrown to jail", that's a big difference with Argentina. But more important, budget deficit was most of the time less than 2%.
It was a massive experiment. Now they have qualitative feedback to sift through and act on.

I think he knew it was going to fail, just not the many ways how it would.
Yeah, I haven't seen a lot that has been particularly useful from Apollo so far.

They supposedly have a slightly different recommended way of doing the things Relay tries to do, but it's poorly documented and only compatible with Apollo, whereas the Relay spec is relatively clear (just the spec, I haven't used the Relay library).

Also they seem entirely JS focused. Our backend is Python and our frontend so far is Swift. They have no Python tooling, and their Swift codegen has a lot of issues, our iOS devs use it pretty reluctantly and replace a lot of parts of it, and even that tooling is all in JS, not Swift, which means our iOS builds suddenly need Node, Yarn, NPM, etc, a whole load more complexity, caching, and so on.
Maybe we hang out in different circles, but I've never heard the level of insults IRL that I have read on Twitter. I have a feeling the large majority of those doing the insulting would be terrified to say those things to someones face because they know a physical altercation would end up being the common response.
Neither secret nor history. For a more objective, less ideological history of the ENIAC era at least, check out the book "ENIAC in Action".
Was expecting some dithering algorithms from the post title.
The OP was def saying IE itself is being dropped. Unless we are talking about a different comment.
That is not true. Unions totally dominated major industries in the US. Most of those that didn't outsource saw themselves become uncompetitive and lose market share to foreign competitors.

Public services that unionized saw costs go up and quality stagnate or decrease.

>There are plenty of examples of countries with strong unions, solid industry/services sectors and workers that aren't being exploited

Like what? Norway, Sweden, Denmark, Finland and Germany? Any countries without strong work ethics and a tradition of engineering excellence? As for the Northern European zone, how has wage growth been in there these past 40 years?
Ginni Rometty was on Bloomberg the other day saying that Hybrid Clouds are a trillion dollar business and that IBM intends to be #1 in the market.

https://finance.yahoo.com/video/ibm-ceo-ginni-rometty-hybrid...

I'm more than a little skeptical on their ability to execute on this, given that they've let a lot of their top-talent go.
Not on my OS (iOS) at least.

Reference: https://support.mozilla.org/en-US/kb/add-ons-firefox-ios
As a Twitter user in the UK I've probably broken this law at least once in the last week - many people interested in politics will retweet anti-western, anti-gay, bizarre ('women on top makes you gay') etc views from Islamists, mainly to laugh at them.
I think UK was the one which inspired 1984, not the opposite.
The UK has a serious problem with the term "terrorism". It's effectively defined as "stuff the government doesn't like". So the Stansted 15 get convictions https://www.theguardian.com/world/2019/feb/07/un-tells-uk-st... but far-right bovver boys harassing government rebels outside of parliament gets a blind eye.
Telegram Desktop is a Qt-based app and it doesn't run everything on top of QtWebEngine.
When I see a paper like this one of my first thoughts is "What will Derek Lowe say about this?" He is a chemist in the drug industry and excellent writer. On his blog he regularly tears apart overhyped claims for how software searches for targets and automated synthesis of chemicals are going to find perfect cures for everything at the press of a button. His take on this paper is actually positive, though with some important caveats:

http://blogs.sciencemag.org/pipeline/archives/2019/02/11/vir...
The difference between Microsoft and Google is when Microsoft autokilled my account, it was only three days of chasing support people to fix it. Neither is good, but there’s degrees to the awfulness.

That’s a big difference when it comes to actually doing business.
Thank you, this added a lot more clarity.
That's really interesting! I'm probably just using my lack of visual imagination as a cop out. Do you have any examples of resources for constructing such a "memory palace"?
as a computational chemist I must say end-use might differ significantly from these screening studies, it is more of a statement on current computing capabilities and a little bit of science icing
Why Exercise Is So Underrated (Brain Power and Movement Link)
Tangentally related. Joe Rogan had Rafinha Bastos on his podcast this week. He is a comedian from Brazil. Apparently, he has come to the US because he was getting sued for making fun of people in Brazil. Similar things seem to happen in Canada for off color remarks "offending" people. I would hope that people of every political stripe in the US think about that. Being able to speak freely is something that isn't to be taken for granted.
RGB values would be handy, eg. "rgb(200, 120, 20)"
Oracle's cloud efforts are just a footnote even when compared to the "IBM Cloud". If Google thinks hiring somebody from Oracle is going to solve their problems, they are delusional.

They'd be better off picking somebody at random from one of the flyover states then sticking to the monoculture.
As far as I've read, ketamine trials have mostly focused on patients for whom traditional treatments haven't worked or haven't had a sustained effect ("treatment-resistant depression" or "treatment-refractory depression"). So I doubt that this is being positioned as something that would attempt to replace traditional treatments.
Pro-Israel Lobby Caught on Tape Boasting That Its Money Influences Washington