skysight-inc/HackerNews huggingface dataset:
This is our immortality we are discounting for a fistful of resources. Sequencing previously unknown sea life has allowed us to find 6 of the 13 genes we need to get rid of mitochondria, a necessary step in preventing cells aging.

(Longer, more detailed version) Early in our evolutionary history, when we were still unicellular organisms, we absorbed another life form that came to live in symbiosis with us. Mitochondrion are like cells inside our cells. They reproduce and are transmitted through the mother. They code for a few proteins we need to survive. Their malfunctions is believed to play a role in some degenerative diseases such as Parkinson or Alzheimer.

Unfortunately, they did not evolve the same complex self-repair mechanisms that our nucleus did. A lot of factors cause mitochondrial DNA to degrade. This gave an evolutionary incentive to find ways for the nucleus to encode genes for similar proteins so that less functions may be impaired by mitochondrial development.

It can't be the same gene though, for reasons that are a bit complicated. As a summary let's say that the membrane of mitochondrion is easier to cross that the one of the nucleus, so you need a kind of shape hack to get it through. Imagine that you are asked to copy a vehicle, but the copy also has to be able to unfold in a way that allows through to go through a manhole. Not trivial.

Luckily, the pressure to find these genetic recipes exists in all the eukaryote domain, which includes all the animals and the plans (and a few other things). That includes a huge number of organisms that we have never sequences or even named. Recipes that work for their nucleus has a good chance of being able to work with ours. So far we found recipes for 6 of the 13 genes we need, but every time a species disappear without us being able to check for these, we may be kissing our ticket to eternity goodbye.

These 13 genes are vital, but I must also add that every gene in living organisms is a recipe for a useful molecule. Remember that spider silk has a higher tensile strength than steel, and that we know next to nothing about organisms that survive in high pressure environments.

Killing species for short-term resources is as dumb as uncovering an encyclopedia written by advanced aliens and burning it for heat.

Could we somehow find these genes through simulation? Unlikely. The protein folding problem is a n-body problem and a billion years of evolution did not find a smarter way than brute force to solve it. And by the way, it ran a brute force algorithm on a billion year in a lab the size of a planet. Realize the incredible value of this rainbow table.

Really, even if we do not care at all about biodiversity on the philosophical level, we should care about it on a very egoistical level. It is likely to be the most precious thing our planet contains: solution to uncomputable problems.
How can you consent to learn about something you don't know about? This is a very different idea to me and I'm trying to understand where you're coming from.
https://interviewing.io

This is exactly what you are looking for. Good luck.

I'm in the same state, got many calls from Google interviewers. I am a little slow in coding hard problems on codeforces. Another couple of months n I shd be good
> The universe is rarely best described by boolean logic.

All models are wrong, some are useful, boolean logic built the modern world. It's a damn useful model most of the time.

> There are other options that are currently not feasible

Which means they are not actually options.

> For example robots could provide everybody's needs

Someone still owns those robots so you're still living off someone else's property/labor.

There are no options where you can avoid paying your own way AND avoid living off someone else's labor. Nothing is free, it came from somewhere and someone who made it happen.

> Or we could genetically engineer people so that everybody finds their particular job meaningful and fulfilling.

People would object to that for a multitude of other reasons, however, as long as your providing for yourself, I don't really care in terms of this argument.
“what do you mean “not true”? I’m saying my son had certainly visited the the cockpit in flight in the last decade. (He’s old enough now that he isn’t really a kid, and also less interested).

I suppose i can’t testify to “most”, not having sampled a majority of the world’s airlines, but certainly on major carriers like Aeroflot and smaller regionals they aren’t so uptight.
Does anyone beside compiler writer write in assembly? For what systems? Why wouldn't they use a compiled language?
I want to ask an annoying question.

Why F# and not haskell?
yeah I mean, it's impressive how they inked a $25m contract on the same day mostly after hours, and had time for their lawyers to write and negotiate the contract and their press people to put out the PR content for it. Like wow, Improbable's lawyers, and Epic's lawyers, and Improbable's PR, and Epic's PR are all so incredibly fast. Especially considering Improbable's own ToS forbids you from selling your game made on Epic's store (https://auth.improbable.io/auth/v1/eula section 4.4), so Epic and Improbable didn't have a standing relationship but started a new corporate partnership in like six hours. Wow, so fast!

or maybe the whole thing was orchestrated? I honestly can't fathom how people are buying the story that Improbable is putting out. It's ludicrous.
If you can get into YC therer is really no risk at all for you.

1. You have enough to cover your costs while in SF
2. If you are good enough to get in, you will never have a hard time to get back into employment
3. Having been accepted to YC will in fact boost your prospects afterwards.

Unless your situation at work is very unusual, there is no downside to getting accepted, only upside.
I highly doubt they would be flagged and instead upvoted. I have seen multiple instances here where a US website has blocked the EU due to GDPR and some user posts the entire content of the article as a comment.
> or is the high tax area drawing only high net worth individuals who have more time and money to invest in their children, leading to higher performing students in the same old schools?

I think the effect is large for schools in particular because schools are mostly funded by property taxes which are directly applied to the residents (either directly or via landlords).

I think the relationship between taxes and any given quality metric is going to depend greatly on the who collects the tax, who delivers the service and what the funding route looks-like. There's much less opportunities for waste if a town is using local tax revenue to pay for local services. It's state and federal taxes are at the biggest risk of being wasted on boondoggle projects and graft.

It's a complex problem. The higher a level something is done on the more overhead and the more opportunity for waste but it also has a homogenizing effect because resources are allocated centrally. Central allocation has big risks (if the central authority doesn't want the things you do you're screwed) and less opportunity for compromise (we will never have a federal gun control solution that results in SF, NYC and Alaska all being happy).

IMO the extra waste is not worth the homogenizing effect or the risk in the overwhelming majority of cases. Government decisions should be made and things should be done (including taxes to pay for those things) on the lowest level possible.
.NET percursor, Ext-VOS was supposed to be an improvement on COM, COM Runtime.

Then they pivoted it into a managed runtime.
I think you are overstating Judea Pearl's argument. He doesn't claim it is impossible to answer causal questions (on observational data) without resorting to do-calculus. What he does claim is that to answer causal (interventional or counterfactual) questions you need to define a model and reason on that model in a way that transforms the question into conditional probabilities. Do-calculus provides a framework to help you perform that reasoning, but certainly people have been using things like the backdoor criterion before the invention of do-calculus to answer interventional questions.

He might claim that any other method can be reduced to do-calculus. I'm not sure. I do believe at the core of his argument is need for an explicit model.
Confessions of a Feminist Heretic
CU Boulder Computer Tiff Sent Apple's Steve Wozniak Back to California
Here is a good article for you to read written by a long time embedded systems guy directed at those looking to get into the industry:

http://www.ganssle.com/startinges.htm
Do you have a source on that? I see contradictory posts here, some saying that grains are good for you and rice is bad, and vice-versa.
I mean, how else are you going to write self-modifying code? It's kind of implicit in the name of the thing that it's going to need to at a minimum have write and exec permission, and read is kind of important to make sure you're actually modifying the right stuff. Yes it's a terrible idea to have write and execute permissions on the same piece of memory, but that's part of why literally the very first line of the article says it's a terrible idea to write self-mutating code.
The problem with these game theory "let's just all work together" solutions is that they are not stable points. It is in everyone's best interest to undercut the cartel. Even if you did get all the peacocks to shorten their tail, if there is some advantage to having a larger tail, it is irrational to expect noone to try and grow it out again.
I'm an embedded software engineer. Here's my $0.02 on how to get started:

1. Get a platform you can tinker around with, and recover quickly in case of disaster. Raspberry pi is a good example.

2. Learn how to find and read detailed register-level manuals of the underlying chip you're working on.

3. Learn what a programmer's memory-model is.

4. Learn what peripherals are, and what they do. You may have to dig a bit into basic electronics.

5. Learn what user-space vs kernel-space is.

6. Learn what device trees are, and how to prevent kernel from taking over a peripheral.

7. Based on above information, write a user-space driver for a simple peripheral (e.g. GPIO or UART) in C (don't try to learn assembly, yet). You will not be able to use the peripheral interrupts in user-space.

8. Learn how to verify hardware functionality, and see your driver in action. (Warning: high dopamine levels are reported at this point).

9. Repeat steps 7 and 8 for all peripherals, and see how far you can go.
Good points overall, but this:

> people with fewer family/community/social/hobby/work obligations, because the more of those obligations one has the less time one has for online discussions

seems like a bit of a category error. There are any number of stable online groups that should be considered under the rubric of "community/social" activities. People participating in them know and expect things of each other, just as they do in a face-to-face group.
This was exactly my experience. It was massively boring and time consuming, except for the meta-gaming/data analysis.

Then when you finally did deal with people, they were tribal dicks and any battles were 100% lopsided to the benefit of the experienced player.

Eve Online is everything great and awful about online gaming all in one lag-filled package.
The premise sounds ethically frought from the beginning. Monetary compensation is always going to have a coercive influence towards people who need it. Sounds similar to eugenic where poor women were paid to be sterilized because it will only influence people poor enough to need $. I'm figuring you aren't taking that route but instead offering payments. Education and resources to avoid unwanted pregnancy such as condoms, access to birth control would seem to be more ethical. A lot of the ethical aspects would depend upon the society that people are living in and their cultural norms.
Or perhaps reclaim our education standard that created STEM in the first place? The Asian method seems to be mostly good for sucking up existing content and spitting it back out, but not producing anything new.

Additionally, the "Asian method" is not actually Asian, as is the case of most practices we attribute to China. These practices (rote mass education, communism, state birth control) are all originated by Westerners, who were unable to sell their ideas to the western countries, and so went east. In other words, we outsourced all our bad ideas to perform massive social experiments with other civilizations. Pretty reprehensible, if you ask me.
Nah, Swift still does not support Windows on their official builds.
I use Apple Reminders for an ideas list. The cool thing about it is that you can set a reminder for when you are in a particular place. That way, whenever I get to my local cafe I get a little popup that reminds me to take a quick look at my list.
Louisiana adopts ‘Netflix’ model to pay for hepatitis C drugs
I've not played Eve in years, since well before player owned structures existed, but I could see this sort of thing evolving to you owning a hanger space on one of the NPC corp's stations. It would seem to me that gets around the issue of people being able to directly declare war on you, but gives a smaller scale version of actual player owned structures.
Are you sure about your epoll statement concerning complexity? 1 thread per client connection that blocks is as simple as it gets to reason about in my experience, and if you don't care about the stack space the thread occupies (mostly virtual anyways) your contemporary Linux kernel handles lots of threads very well.
The YC program is cash flow positive for you as an individual, that’s the point...

Just fail fast and get back to your normal job, wiser and more experienced, and with a much improved CV.
Very easy to miss seeing the image thumbnail, it appears on the extreme right, and if you don't scroll horizontally, not visible.
Marking isn't the problem. It's fitting a minor + major heap into 2K. In my (small, but not very optimized) ML implementation a useful minor heap is probably min 64K.
I don't play Eve. Is it possible to patrol inside the wormhole? If possible, is it practical? (e.g., if there's a lot of volume to be covered it can be possible but not practical.)

If so, this is going to be a one-off event most likely.
This seems incredibly sketchy, almost like it was a coordinated campaign against Unity. I'd like to hear more from Unity's side because the speed at which Epic capitalized on this is suspect.
Really? Then why doesn’t it work?
I looked into the citations and they seemed reliable, so I trust it. Just put it there because it presented the point succinctly.
Most of the products are pretty terrible or lack innovation. Seems like things I would have found at a sharper image 20 years ago. That being said it doesnt preclude them from success considering electric scooters just became a billion dollar industry.
...So what?

Comment content is governable in the site ToS, where copyright assignment or other methods of defining the respective user/site rights can be dealt with.

Even if it wasn't, your performance in posting implies consent to provide at the very least a limited license to publish content you posted.

So where's the beef here?
I've gone from being an admin and owner of popular forums back in the early 2000's to just a lurker who 98% of the time will write a response but just delete it before it's posted because I don't need or want the hassle of an internet argument. I'm proud of even posting this. Maybe this is my one post for 2019. :)
No, your personal definition doesn't matter. If you buy/scrape a list of email addresses, and send to ANY of those addresses, that's spam. I work for an email marketing software company. That's the definition used in the industry. >0 unrequested emails is spam.

If you've never spoken to this person before, you have no business relationship with them, and they have not opted in to receive mail from you, you are an email spammer. You can mince words if you have to to sleep easy at night, but this behavior is wrong.

The author of the article did something shady and you are defending him.
It's not just the costs, it's attaching a 20M EUR risk to activity that may not even be worth 20M of revenue.
We've been getting warned about reaching peak oil / diminishing oil production, but so far that hasn't happened yet as far as I know (that moment has been postponed again because of the highly destructive fracking process)
Thank you! I forwarded your responses to a friend who was interested too.
The idea of writing A in binary and forming the 0/1 polynomial such that p(2) = A is nifty. Then if you factor p(x) it into two polynomials with integer coefficients u(x)v(x) you have u(2) and v(2) are divisors of A, so if none of them are equal to +-1 you have found something. Assuming it is easy to factor the polynomials.

Factoring polynomials is somewhat easy, but you have to specify factoring into what.

The terminology needs a little clean-up. By the fundamental theorem of algebra we know every polynomial over the reals factors into a product of polynomials of degree no more than 2. So they probably don't mean factoring/primality in general but a definition of factoring in to square-free polynomials. Factoring into square-free polynomials is easy as if q(x)*q(x) divides into p(x) then it also divides into p'(x) (the derivative of p(x) with respect to x) and therefore divides into gcd(p(x), p'(x)). And the gcd() will have integer coefficients and be degree less than p(x) (so not equal to p(x) and degree >= q(x), so if q(x) is non-trivial it forces something nice to happen; even if you don't know what q(x) is).
My current startup has taken VC funds. Never again. What a nightmare.
The claim of the study is that they can investigate prevalence of fake news sharing of different groups, so the concerns is more expansive than that and puts the scientific validity of their conclusions on dubious grounds.

There are four questions that need to be answered:

1) are the classifications complete over the data set in the study, not an arbitrary different data set

2) is the populations studied representative of the populuation in general

3) are the classifications unbiased

4) are the classification structure sufficiently granular to represent uncertainty

On #1 they did their study on a three-month segments beginning 9 months from election day, while the study by YouGov is over a different set of voluntary users in a different time period.

On #2 the population was chosen by voluntary particiation and I don't see any mention of them doing necessary statistical analysis to make sure it is representative of the general population.

On #3 and #4 buzzfeed said they collected the classifications by searching for fake news of interest to people of their ideological tilt. Some of which is admittedly not fake news, such as hillarys mishandling of government emails:

-- BuzzFeed News used the content analysis tool BuzzSumo, which enables users to search for content by keyword, URL, time range, and social share counts. BuzzFeed News searched in BuzzSumo using keywords such as "Hillary Clinton" and "Donald Trump," as well as combinations such as "Trump and election" or "Clinton and emails" to see the top stories about these topics according to Facebook engagement. We also searched for known viral lies such as "Soros and voting machine."

and

-- Two of the biggest false hits were a story claiming Clinton sold weapons to ISIS and a hoax claiming the pope endorsed Trump, which the site removed after publication of this article. The only viral false stories during the final three months that were arguably against Trump's interests were a false quote from Mike Pence about Michelle Obama, a false report that Ireland was accepting American "refugees" fleeing Trump, and a hoax claiming RuPaul said he was groped by Trump.

I am sure many other problems could be found if I looked more, but just one of these would put a nail in the coffin of their conclusion and together they just put it on dubious grounds.

[1] https://www.buzzfeednews.com/article/craigsilverman/viral-fa...
I was hoping for an example of a startup he has chosen to not fund because the people didn't meet that criteria but maybe the idea was seemingly bad in a good way
The main reason was that team had more experience with F#. I think it is also more approachable than Haskell for OOP devs (C# to F# comparisons are quite common on the internet). I'm sure Haskell would also have been an excellent choice though :)
how can you say you are "an ardent capitalist" but opposed to partisanship and propaganda lol? do you think supporting capitalism over socialism is outside the realm of partisanship?
Fun! Works well in chrome. Stuff are cool but a go back (history-1) or go to homepage link would improve this page I think.
How absolutely fascinating!

For me it is instantaneous. I pick up a book, and from the very first sentence I'm in the book's world. Sometimes I get jinxed by thinking about 'these are just letters'. That's almost like remembering that you're consciously breathing or being aware of the size of your tongue.

But I can get rid of that within a minute of determined reading.
On a related note, if I'm sick and I manage to get into a book despite the initial discomfort I can ignore my pain/sickness completely.
I have STEM degrees, but barely any strategy, and have done alright for myself and my family. My childhood was homeschool until high school, and pretty free range. Did zero extra curricular activities except ROTC in college, which got me my first job right out of college in the Air Force.

It seems like there are plenty of non STEM blue collar jobs that afford a nice life, but the problem is they are looked down on.

I think part of the problem is that everyone is optimizing for the same niche, which makes that niche very crowded and requires extreme amounts of optimization to succeed.
Postgres 12 highlight – pg_promote
All the information that we have on VR headset HTC Vive Cosmos
Childhood Trauma Exposure Is Common, Raising Health Risks in Adulthood
Precisely. Those actors are still outliers, just as almost all reddit commenters are outliers. Outliers aren't defined by being good at their activity, they're defined by doing it sufficiently more than the rest of the population. That's why I said there isn't much of a difference between Wikipedia editors and actors as concerns their relative skill over the total population.
Why is it set up like that on HN?
There are post-mortem crashes where the only thing I can look at in the disassembly. It's not if they write in it, but if they know how to read it. It's more useful, particularly in some cyber security subsets.
Chromecast Audio Officially Discontinued
Hi uvu,

It's not possible to know and remember everything, I would reccomend you take a read at Dan Abramov's blog post, 'Things i dont know as of 2018'.
I think it should help aleviate any fear of forgetting or not knowing something.
Keep notes on things you find interesting, break harder things into smaller problems and most importantly keep trying and have fun learning.

https://overreacted.io/things-i-dont-know-as-of-2018/
Think about units, tens, hundreds, ..., and stare at step 3 in the article.
San Fran? That's in NYC?
The CBO Expects the National Debt Expense to Overtake Military Spending
"It's almost impossible to find a "fair" fight, even as a person with several months of experience under your belt, to the point that it's kind of a joke."

This is why I prefer Starcraft and Dota. Both games start with a clean slate. No matter how many games played you have under your belt, you and your opponent are on an even footing at the beginning of the match.