skysight-inc/HackerNews huggingface dataset:
That's true because it's not trivial to launch a new drug/delivery system. Even generics have to prove that their drug matches the kinetics of the patent drug and has other similar properties. There is still an FDA process to approving a new drug, and if I'm not mistaken, the new delivery device also has to have it's own approval through the FDA medical devices division.

All of that is before you even take into account how much it costs to re-tool your production line to make something different. Sure, you could lower the barriers to entry until they're barely existent and offer almost no consumer protection, but I'm not really sure we want to make it so easy that a company will spin up a production line to make a drug for 6 months while they think they can undercut the competition.

Then again, I'm a big pharma biologist, so I probably am a bit biased toward safety and large, slow movements.
Why do you think so many developers use things like Bootstrap, Foundation, Bourbon, Bulma, etc as starting points and languages like LESS and SASS to keep it modular/readable/maintainable? We've had CSS libraries and frameworks for years now.
> It's probably the only country in the world where "used homes" are considered something to be ashamed of.

That's generally true though it depends on the specifics e.g. they would renovate and maintain things like temples, ryokan or major multi-generational homes.

It's the "personal" homes which are considered disposable (pretty much anything you'd have in a suburbs in the US for instance).
If the network is reachable from the outside and there are other block producing & validating nodes elsewhere, then this could be an interesting setup for enterprises after all it's a P2P network.
Users are not discerning enough to look for the padlock; they'll get taken either way. They are not the problem here.

The bigger problem with this is that the paths being requested can't be monitored by intermediary devices unless you're MITMing all outbound traffic.

It becomes impossible to tell whether a domain is simply cybersquatting or if they're up to something more sinister. '/' may return a parking page, '/login' may return a phishing page, and '/?id=c4010087800cf4e5753c80c9afbe0fe5' may be a malware callback, but as far as you can tell from your network logs all traffic to httpx://www.xn--bbox-vw5a.com is simply requesting '/'.
Indeed, they wouldn't - but the product offering sounds like they are telling customers that they can audit their data and that it is cryptographically verifiable - but why does the customer care about this, unless they don't trust amazon to preserve data integrity?
Ah yeah, looks like they rolled out some new plans with the change up, or I didn't look at all the options when I last looked.
Kevin Federline
I love things like this. It's beautifully recursive in a way: AWS sees a lot of machine learning, AWS adopts tools to help people do it, people see training data problems, AWS has some machine learning expertise and realizes that they can help you auto-label your dataset.
Sorry if this sounds rude, but please be sure to add a disclaimer that you work at Amazon if you're going to be posting recommendations for AWS products on HN.

It already seems like Amazon is astroturfing HN this week with the 12 AWS articles currently on the front page (with 8 of them being posted by a different Amazon employee), and it doesn't help if Amazon employees are posting recommendations while pretending they don't work there (your use of the phrase "they" when referring to Amazon is a little weird)

edit: You keep replying to this comment mentioning how you don't work there and don't have any ulterior motived, and then deleting it. Why? You do clearly work at Amazon based on your previous comments [1], which link to a GH profile that clearly says you work at Amazon.

Whether you work specifically for AWS or not, it's still a conflict of interest for an Amazon employee to be posting recommendations for Amazon products and pretending not to be. It would be appropriate if you added a disclaimer to your original comment.

edit: removing links to other user's profiles, etc
The former.

It is known that we can reconstruct MR images at full fidelity- with no loss of information- by randomly sampling "k-space" at something like 10% of the usual sampling rate. This leads to much faster acquisitions. I believe Siemens has a product based on this technology that is currently going to market- https://usa.healthcare.siemens.com/magnetic-resonance-imagin...

One issue, though, is that truly random sampling isn't great from a practical point of view. Sampling patterns are constrained by other equipment considerations. There is also the issue of noise.

Machine learning for MR (and CT, and PET/SPECT, and...) is an active area of research, eg https://arxiv.org/pdf/1705.06869.pdf
People don't tear down their own homes (though the home may get torn down for them by e.g. an earthquake), they tear down the house on the land they buy when they move, and get their own house built on it.
It's unfortunate that people waste so much energy being plugged in when they don't need to be
Perhaps, but I belong to groups based on my interests which are completely orthogonal to race: my Church, various interest groups on Facebook, etc.

I work at a small company (c. 600 people), so it isn't big enough to have these kinds of groups, but I'd be more interested in joining a group based on interests, like software development (I do work for a software company), or maybe tabletop gaming. I don't care what race people are, but what their interests are like. Of course, I'm a white guy, so there wouldn't be a white guy group (nor would I want to see one).

And for what it's worth, there are a lot of immigrants at this company, so whites are a minority among mostly Indians and Chinese, etc.
Yes? Name any domain and there's somebody who wants high-throughput auditable transactions in it.
I try to make it profitable if I'm staying longer. If I stay for a long time, I will 'renew' my lease by buying more drinks or snacks :D Places that are friendly and welcoming today…I've gotta make it PROFITABLE for them to stay in business if I want them to be around tomorrow…
> The ETH example you mention was a PoC. It did not generate revenue and is not a business. Don't get me wrong. I think it's great, and it might be technically very impressive, but it's not generating money. It's not a business.

It's not even technically impressive. They're literally using Ethereum as the backend database so the guy running it can say "Blockchain!!" a lot, 'cos he's a hodler. I tracked down the details: https://davidgerard.co.uk/blockchain/2017/11/26/the-world-fo...

The programme does great work! But nothing whatsoever about it is Good News for "blockchain", except for PR purposes.
Posting the same comment on every single one of these doesn't help anything.

Basically, you're just spamming.
Picking some minority view and ascribing it to all of your political opponents seems to be a very popular tactic nowadays, on all sides of the political spectrum. All it does is raise the level of hateful rhetoric, and does nothing to actually help people discuss the actual issues. Because of flaws in the way our minds work, it continues to work, and people continue to use it.
There's a multi-writer feature for Dat under work.
I believe a lot has to do with advances in Earthquake safety making it preferable to have a new house.
Tell HN: Sendgrid increases price by almost 50%, weeks after acquisition
Just received this email.

"As a valued SendGrid customer, we would like to inform you of an upcoming price change to SendGrid’s Essentials plans, effective January 1st, 2019. This change reflects ongoing investment in our infrastructure, products, and services, ensuring that we continue to provide you with a best-in-class experience.

Your Essentials 40K plan price will change from $9.95 per month to $14.95 per month. Please note, this pricing will be in effect for new customers on December 1st, 2018, but as an existing customer, we’re providing you with additional notice in case you have any questions. Your January bill will reflect these changes."
Re:invent week. Expect a lot more.
Having been to schools and companies where I was the only member of my race and religion, a race or faith based group has not been an option more often than it has for me. I've also worked in organizations where I was sexually in the minority.

This has made me learn how to build connections based on interest and experience. Doing so is easier than it seems. We share a lot with each other: most went to a school with hundreds, even thousands of students. Most have had family members that we dislike. Many of us deal with sickness, depression, and difficult experiences. Many of us are passionate about an activity of some sort.

I encourage anyone - black, white, brown, woman, man, mixed, other - to seek connections based on common interests and experiences.
Well that was a pile of hot garbage.

"Blockchain groups now exist at every major university in the world and the number of people who own some kind of crypto digital asset continues to rise."

The same could be said about alt-right cliques or communist groups, both of which are growing too. Not such a great metric for progress.

“The idea of cryptoeconomics becoming embedded in the 5G video and voice-AI internet is sort of inevitable.”

Really? I've got friends doing research and development related to those fields and they seem to have a very different view.

“Cryptoeconomics must be tethered...”

lol.

"...to and converge with the key exponential technologies of the future: quantum computing, machine learning, the Voice-AI interface, 3D printing, Biotechnology and whatever other important changes to human life occur from the intersection of technologies."

The rest of your article seems to be spewing incessant buzzwords without actually outlining any coherent argument or model for how this would actually work.

Finally, as much as I don't want to use ad hominem, it seems fairly unlikely that a content writer has any kind of professional knowledge of economics or technology to actually make any accurate predictions about the future of either field. Predicting the future of either field is extremely difficult, even for experts. Hand waving and claiming things as "inevitable" does not put you on the same level as a thought leader, it puts you on the same level as a cult preacher.
Summary:

- Next version will be 3.0.0 which is major.minor.patch (v2 was used for OpenSSL FIPS). The letter will not be used anymore.

- Next version will be under the Apache 2.0 license instead of "Apache License 1.0 and 4-clause BSD License"[1].

The main difference between Apache License version 1 and 2 is that v2 is compatible with GPLv3. There are some other changes like clarifications and requiring a patent if you contribute code that would infringe a patent that you own. For an overview of Apache2, see [2].

Overall, doesn't sound like a large change.

[1] https://en.wikipedia.org/wiki/OpenSSL

[2] https://choosealicense.com/licenses/apache-2.0/
Machine Learning algorithms and model packages now available in AWS Marketplace
I'll pay for it. Sounds like a win/win unless you hate money.

But who wants to spend any time or money at all in a café that's designed to be hostile to customers?
That's exactly my point. Apparently Amazon is being spammend all over HN. What the heck?!
I hope he can make some better life choices.
I doubt it's "we share a skin color, let's hang out" for anyone.

It's more of a "we share the same challenges and hardships, let's compare notes" mentality.
AWS Marketplace: Machine Learning and Artificial Intelligence
And yet my mother is 100% convinced that the generic of a drug gives her chronic headaches while the "brand name" version doesn't.

If I'm not mistaken, the formulation could be wildly different as long as they match kinetics, yield, and safety profiles set by the FDA, and an individual may have some issue with one formulation over another.
Amazon is the best partner until you prove worth cannibalizing.
https://dilbert.com/strip/2018-11-26
AWS Reinvent is happening. Kind of like how's there's a lot of Google links during IO or a lot of Apple links during WWDC.
The AWS conference is going on:

https://reinvent.awsevents.com/
Something very wrong in the stack there. There should be a delay in the video in order to compensate for the latency sending the audio to your ears (Bluetooth does not add much here but it all adds up) and you should experience no latency.
This always happens when Amazon has one of their conferences with lots of product announcements. Whether Amazon employees are actually making submissions here, or whether it's all purely organic, I can't say. But it's pretty much par for the course, at least over the last couple of years.
I predict many confused/rushed tech journalists will write articles that mention "Amazon already has a Quantum Computing Product" after this.
I'm pretty sure this is what most people actually want when they say they want a blockchain, they just don't know it yet. It's got all the useful database features with none of the "well uh let's distribute it over people's computers and let people mine coins to support it" complexity, which adds nothing to 99% of usecases besides silly ICO potential.
Curious what's the strategy you use to invalidate browser cache for non-SPA? When deploying new changes.
To be clear, I don't believe any part of Google's ad side has ever influenced their life sciences division, as it has been led by the same man, Andrew Conrad, since 2013. That being said, Andrew Conrad still works for Google as a subsidiary CEO, and I hope he continues to do great things with Verily.
This is false - the demand comes from the project lead being an ETH hodler who wanted to shove a "blockchain" in there somehow, even though it makes literally no technical sense: https://davidgerard.co.uk/blockchain/2017/11/26/the-world-fo...
Welcome to AWS Re:invent week, friend.
There are likely feminists who would be OK with the alimony pendulum swinging the other way as a result of gender parity in salaries and careers.
acting once the kangaroo court has been invoked, and after pitchforks primed to push the company ever so slightly towards the flaming stake of public shame are drawn, is not impressive.

getting support right the first time should be news. consumerist style resolution is at best neutral, and at worst still disappointing.
I read that as "$400 used" and I was about to freak out thinking of what a used EpiPen would be...
I am a white male and in my department we have a lower percentage than a lot of the groups who have an ERG. Sometimes I toy with the idea of opening up an ERG for white males. I wonder how this would come across.

I don't really understand why all these groups are around race, sexuality or gender. This seems to me the opposite of diversity. In my view there should be groups around interests instead.
My daughter has used the Auvi-Q as an alternative. In addition to the active injectors they provided a test one that helped her when the time came: https://www.auvi-q.com

I have not heard of any issues with Auvi-Q since it was reintroduced
The point is that past a certain point, things will get wild.
From a centralized source?

So sure. Voting. Wouldn't it be great to have an auditable trail?

But why would you then go and put all of that in one spot?

Wouldn't a better approach be reconfiguring the tech to work in a faster fashion?
How does an empty café with bored looking staff invite new customers in?

When I go into frequently-empty places I find that the staff, who should have all the time in the world to help, are actually more distant, because they're so used to filling up their time chatting together or doing other stuff that when a customer actually does show up it's like some unforeseen situation they didn't plan for.
A Structured Approach to Unsupervised Depth Learning from Monocular Videos
Have you looked at Clickhouse for timeseries data? It's the one database I've found that can scale and can query in near-realtime.

I've loaded a 100 Billion Rows in into a 5 shard database and can do full queries across the whole dataset in under 10 seconds. It also natively consumes multiple kafka topics.
The former pharma exec working for HHS to negotiate lower drug prices committed suicide about a month ago.

https://www.cleveland.com/metro/index.ssf/2018/11/death_of_h...
He sold his blog network to AOL for $25M. And that was just the beginning
Seconded. It helped me clear up some FP concepts.
AWS-Exclusive from my understanding. Not in AWS but from reading other comments, it sounds like this has been widely used internally for some time.
I got a lot of traction in my early days simply ignoring the requirements and asking myself if I could do the job.

Some skills can be picked up easily. Others are difficult to teach. You have a detail oriented position, you need a detail oriented person. If they’re sharp they can learn pretty much everything else.

Hell I’ve taken over internationalization coding because I understand how grammar works in two languages and an inkling of Japanese grammar. I couldn’t translate a UI to save my life but the hard part is stitching sane sentences together from data.
Yes nearly everywhere plays music nowadays. I think it's to drown out the feeling of existential dread of actually having to hear yourself. Don't think about it too hard people, just buy more.
Have you never had to work while traveling? The prevalence of internet cafes has been priceless to me over the years. I travel a lot, and having cafes to stop and work at while on the road has allowed me to be a lot more flexible with travel/work arrangements. I find them very valuable.
No, apartment buildings don't get town down as much, although the japanese tendency of buildings having limited value means as urban centers "grow out" first suburbian plots get torn down and merged to build a low-rise (2~3 floors), then that might get squared away for a mid-rise (half dozen floors or so), and if the city center grows enough that would ultimately get replaced by a high-rise.
IIRC, the original PR for this gave the idea that automobiles would enter the tunnel through single-car elevators that looked like parking spaces. How many such elevators are needed to keep a high-cost roadway running reasonably full? How much infrastructure (safety barriers, driveways, waiting areas, not to mention people) around each elevator to move the cars on and off safely?
Not just martial arts, really. Dance would work too. That's just one romanticized aspect of the martial arts for me.
Completely agree - what I'm wondering is why they are telling their customers that they can verify the data for themselves, when that is entirely pointless: "and using cryptography, you can easily verify that there have been no unintended modifications to your application’s data"
We currently have a Dropbox Business account with 16 users.

We use their API to do some data pre-processing in the cloud on some of the data when it is being pushed in the Dropbox.

A few days ago we reach the monthly 25.000 API calls limit, and contacted support to upgrade our plan, as they tell us to do on their pricing page [1]. That is the response we got earlier today.

---

[1] https://www.dropbox.com/business/plans-comparison
Doesn't divorce court also consider domestic violence history when deciding how to divide things?
Most big tech companies bundle their announcements on their annual conference day. It happens several times a year and these same complaints show up every time, but spamming the threads with them is excessive.

https://hn.algolia.com/?sort=byDate&dateRange=all&type=comme...
I think the article should state clearly if the price is with or without health insurance.

I bought a generic epipen this year for my daughter and the co-pay was $4.
I have YouTube Red so I can listen to YouTube videos in the background on my phone, but I don’t think I’ve ever watched a complete YouTube original.

If anything, I have a general sense when I see the “Original” tag that it’s probably overproduced and flimsy content relative to normal YouTube videos. The marker is probably anti-selling the content to me at this point. Even though I’ve ostensibly “paid” for that content.

Contrast to Netflix Originals which I generally assume are at least mildly relevant, interesting, and/or produced by reputable creators.

I think Google messed up by going after the most popular creators, who are mostly playing a game of clickbait and lowest common denominator attractors.

Netflix did the total opposite, forgoing the big name filakers and finding artists who have niche audiences that were previously considered too small to fund.

Google needs to realize the “Top Youtubers” and “People who need funding for a small but traditionally produced film” are very different categories.
> But yet when the very idea of alimony is "I'm a lesser woman because I married",

That's not the idea of alimony.

The idea of alimony is closer to “I sacrificed my future income for my husband's by the division of domestic vs. external work in marriage”.

> Say.. How many men get alimony?

A small but growing number, largely because of slow erosion of persistent patriarchal gender roles which manifest in a number of ways.

(1) Men are still more likely to support their wives and have their career advancement and future income potential dominate in marriage than vice versa, making them less likely to be eligible for alimony,

(2) Men are less likely to seek alimony when they are eligible,

(3) Men are less likely to resist alimony demands in divorce,

(4) There's bias in judging where judges are more likely to view men as capable of independent self-support and less deserving of alimony in objectively similar conditions.
AWS launches a managed blockchain service
How can you make something like MakerDAO on a centralized ledger?
Keira, nice article. It will be a long time before we are allowed to use this new service in C1
I really don't think it's 20x the cost of Aurora in general, considering that Aurora costs are not that simple, but I don't have time to run the numbers, so let's go with that for a moment. Do you really think Amazon would introduce a product that's 20x as expensive if they didn't know there was a market for it?
> IBM sells blockchain solutions. I bet they've made some money doing so (at worst because they could probably sell digital toilet paper and make a profit off enterprise contracts before they phase it out).

Conference gossip is that this is not the case, and they're experiencing internal pressure to show a production system - any production system - and then to show one that makes back some of the money they've ploughed into this.

e.g. IBM's systems for Walmart and Maersk are completely centralised, but the back-end database is Hyperledger, so they're being trumpeted as "GOOD NEWS FOR BLOCKCHAIN" - the correct perspective is "with sufficient thrust, pigs fly just fine", and boy are IBM strapping Porky to a rocket.
Maybe they just want to quell the blockchainia.
Hardoll Super Bright Solar Lamp for Home
This is the same experience. They bombard you at renewal time, but ignore you and apparently don't even allow upgrades during the rest of the year.
There was already had DynamoDB Auto Scaling to achieve that. Main benefit of DynamoDB On-Demand from my point of view is:

- easier setup (a single setting instead of configuring auto scaling rules and policies for the table and all its indicies)

- possibly cheaper (depends on the not yet published details of the per-request pricing)
Hey, I only said 99%.
Yeah in particular I think one of the things people are really going to appreciate about QLDB is that you can query it with SQL like expressions. Instantly familiar and almost drop-in replacement for many apps vs trying to build your own Blockchain ledger