skysight-inc/HackerNews huggingface dataset:
"Blood samples had 5-6% unmapped reads compared to 7-18% in saliva. Evaluation of source of unmapped reads found that 0.54% mapped to viral species in both sample types. In contrast, 10.3% of unmapped reads from saliva samples mapped to bacterial species, compared with only 1% of unmapped reads from blood samples as expected1. This analysis represents, to our knowledge, the first comprehensive examination of WGS and WES data generated from blood compared to saliva. Our analysis shows a high level of concordance between the two sample sources, and as expected few somatic variants. This indicates that high quality sequencing data can be derived from saliva samples for germline genetic analyses." [1]

and

"SNP genotyping results for saliva derived DNA (n = 39) illustrated a 98.7% concordance when compared with blood DNA. In conclusion, when compared with blood DNA and tested on the DMET array, saliva-derived DNA provided adequate genotyping quality with a significant lower number of SNP calls. Saliva-derived DNA does perform very well if it contains greater than 31.3% human amplifiable DNA." [2]

[1] https://www.researchgate.net/publication/309849150_Saliva_is...

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309006/
It wouldn't since most of Clojure functions would be poor match for the GPU hardware.
Ask HN: What is the science behind CrossFit?Is it safe to practice?
Is there a TL;DR? I see the whole spec is there but I don't have time to read it just this second.

Does it use anything fancy like fountain codes or does it just renegotiate chunks each time or something else?
Love the work that Janko is doing in our ecosystem! There are implementations for most major languages. So a tus server could even just be some php code that you install with composer and add to your existing Apache setup.
Not an American :) But it pushed me to un-google myself and switch all my data to Apple. They do security properly. I have not a single byte of Google code on all my desk/laptops and phones. No Chrome, no Android, no Gmail, no Google Maps.

I do feel less stressed now, because i was aware of what he made public. As for general public, I believe it added stress, and it is right thing, it might lead to some changes, and slow down surveillance apparatus.
I've been telling people for years that FB is the next AOL or Yahoo. The writing has been on the wall for most of this decade to be honest. In fact, some of my first posts on HN were about this. I should apply to YC...got nothing to lose, everything to gain.
http://videodownloadlink.com
According to the web site, it is global. The price quoted for Europe is 169 euros.
The Spaniards did far worse to the natives.
Modulo sharing BazQux Reader (https://bazqux.com) has the same Google Reader simplicity plus some additional features. Try it.
Cathay Pacific, Cathay Dragon display show of strength in cargo volumes in Oct
I've had the same experience.

Recently, we were visited by my sister-in-law. We ended up talking about a topic, say Topic X. Topic X _never_ comes up when I and my wife are alone; it is simply not a part of our life. We have been married for 15 years, without talking about it even once.

However, it did come up while talking with my s-i-l, and my Android phone was lying nearby. Minutes later, after my sister in law had left, I was presented a Topic X - related ad on YouTube.

It was displayed only once, I ignored it, and no Topic X - related ad was shown after that.
Thanks! All native apps I use require internet connection anyway (reddit, Facebook, online games etc) but I guess I'm not a good representation.
Regex support is amazing to have in a search engine too... For example, paste in an email address validating regex:

https://cs.chromium.org/search/?q=%5Cb%5BA-Z0-9._%25%2B-%5D%...

Considering that one can't 'index by regex', I wonder how the backend works - does it actually run the regex against every source code line in the repository in a few hundred milliseconds? Sounds expensive! They must have thousands of machines! Maybe thats why they don't have a public codesearch tool for the whole internet...
Well done!

Everybody who's interested in multiple platform emulation with a nice UI should check OpenEmu: https://openemu.org/
I passed the 10-week mark and still nothing. If I don't get my data in 2 more weeks, I'm contacting Amazon and FTC.
In the genetics world, when you say the words "Gold standard", that usually translates to "Sanger sequencing", which is a high accuracy method of sequencing a small section of DNA, like a single gene. I don't think your statement is very helpful in that context.

Most of the world's whole genome sequencing is done using the Illumina platform. This service is using the BGI platform, which is arguably higher quality than Illumina. Our lab has data showing the error rate with BGI is about 1/6 the error rate of Illumina.

Yes, there are some even better sequencing technologies out there, such as PacBio, which provides longer reads capable of sequencing slightly more of the genome, and the error rates are constantly improving. However, these technologies are much more expensive.
If you can find a public URL showing this issue, don't bother with debugging it. Just post the URL on GitHub.
"visible from space", still waiting from the picture from Space. I can smell the bullshit or the google map picture highly zoomed... but if they can zoom on your house they can zoom on those too, no need add this in the title.
The scenario you describe was what happened with the Air Canada flight: 28L was closed and lights off, so the Air Canada flight that was cleared to land on 28R nearly landed on taxiway C, where 4 airplanes were sitting waiting to take off (and apparently came within less than 5 meters (15 feet) of hitting one of them).

This btw also points to problems with the NOTAM system.
Am I an active user?

Yes

Am I an active user?

Yes

Am I an active user?

Yes

Am I an active user?

Yes
What I'm finding thrilling is having (since Game 9) Anish Giri, Alexander Grischuk and Peter Svidler commentating together on chess24, and streaming live on youtube. I don't think there's ever been a commentary team nearly so strong - current world #5, #9 and #19. And it's free. Thank you internet!

https://www.youtube.com/user/chess24media/videos#top
Learn about Google Launchpad Studio Program
Next.js Page Transitions with Element Morphing
> There is simply no viable competition for Facebook in market right now like what Yahoo had in terms of Google.

I don’t know if it’s your argument for the decline of facebook being false, but it doesn’t have to come from competition or viable alternatives.

People stopping doing something happens all the time, companies going down because of decreasing interest in their service is a normal thing.
Just a quick post to show a new library I put together built on top of the work here: https://github.com/illinois/next-page-transitions

This modifies the existing library and adds element morphing between pages. The elements only require the same id across pages, they do not need to be children of the same component.

It's not perfect yet but thought I'd release what I've done so far.

The link is in a serverless container that ramps up and down based on usage so if the page takes ages to load its because the container hasn't been hit in a while.
> I would go on a limb and say that Amazon doesn’t invest in better UX because that’s not what most of their customers care about. Someone at that company has already done the math and decided investing in Amazon Go or 1 hour delivery or Whole Foods is a far better return than investing in UI improvement.

I imagine a company like Amazon has the resources to do both.

> I do think people in this discussion are looking at this from a developer or designer point of view. I read some article a while ago about how Amazon saw a increase in sales from millisecond level improvement in page loads. I bet that’s what they optimize for, and less so on how pretty the UX is.

Same point. These features, performance and an attractive user interface, aren't mutually exclusive. I'd argue that in fact both are tightly coupled and are part of what makes the design and user experience.
Nice to see someone noticed this one. The ideas are indeed great, so spread the word. Really want to see this features in every code editor in the future.
Any ideas how a website can protect itself in this situation?
This story is software not journalism, but React had a similar reaction. Best practices at the time were to slice things vertically (MVC) rather than horizontally (components).

The mere fact it was Facebook pushing it basically saved it from being drowned out by people in the audiences at the first two conferences (jsconf / jsconfeu) it was presented at who simply didn't like that it wasn't MVC.
Robbing banks, bankers, insurance companies and other 'powerful people or companies' is wrong, basically universally.

There is no ned to see any film about this.
Useful collection.
Where do you make money on your career site?
Sorry to be so direct, but who cares about your DNA? People are so full of themselves thinking they are something unique and of great value. In fact, everything valuable in us is our brains - experiences and knowledge. Plus, don't worry so much about your mom and her 23andMe - that's not sequencing, it's just a test for a list of snips (SNPs).
Plane-spotting helps my autistic son
Yahoo's acquisition track record goes beyond unlucky picking, it shows that they can't maintain or grow the services they bought either.

Compare with Google: Maps (Where2), Earth (Keyhole), Waze, YouTube, DoubleClick were all acquisitions they grew to be far larger under Google than they were before.

Disclaimer: I work for Google, although I have nothing to do with acquisitions.
The realities of a blockchain-less digital currency with 18 quintillion shards
Joseph Nacchio, former CEO of Qwest (now owned by CenturyLink), refused to surveil his customers at the NSA's request. Shortly thereafter, the NSA dropped a major contract with Qwest that they had been relying on to meet earnings targets. A few years later, he was chargrd with insider trading on the grounds that he made statements about earnings that were unachievable while selling his own shares. He attempted to claim in court that the charges were retaliation, but his evidence was removed for national security reasons.

His case was covered in the news, and he still went to federal prison for four years. And every other US telecom CEO knows it.
A key problem with some of Yahoo's acquisitions is that they missed the right point of the curve: buying things once they were already Quite A Thing. While this may look like a safer gamble than buying something small that might be a thing and the next big thing eventually, but might be nothing at all next month, getting in late can have two key problems: already being a thing means it commands a high price, and you already have an invested user-base who may fight tooth-and-nail (or simply leave) when you inevitably make changes.
Well, technically you can also dismember a journalist that way...
Actualy if the life of that middle manager is mildly miserable they won’t have the time to look back or regret, or really think about what they are doing for a living.

And by definition they’re sandwitched in a hierarchy, that can be a hell of its own.

I’d argue the health of our society could come from healthier life for these corporate workers.
git was easier to use :) - thanks will check it out
6-Figure User Onboarding Mistakes to Avoid
Buy Trustpilot Reviews
2010 17 inches Macbook Pro. This machine is a tank. Still using it. Still productive.
Apple reportedly resumes iPhone X production to recover from dismal sales
Left-field option; embed zerotier SDK. They do a better job selling it than I could: https://www.zerotier.com/blog/zerotier-sdk.shtml

Probably some head-banging required to get it to link/load/run (I see there's an open ticket for Python). Would likely need to do a little bit of c/c++ to get that working properly. Benefit is, you would then never need to touch the p2p layer again and you could just be doing web development if that's your thing.
I like that the language is a part of the name.
> living in the world of mostly ascii-limited code this looks exotic

this is is not the world where everybody lives. I live mostly in the world of math books, where all variables are single letters (which is the main difference here, and not the use of unicode). I tend to find code written by non-mathematicians ridiculous and unreadable.

Instead of

E = m * c^2

they seem to prefer bullshit like

thing->Energy = thing->Mass() * np.math.pow(lib.constants.speedOfLightInVacuum,2)
Oh forgot to add the URL to the github repo: https://github.com/Irrelon/nextjs-morph-page
That's great. I was personally on the fence about it because 1) the MK is much cheaper than SK and 2) the tactile of the MK is so much better than the SK.

I think I will go with the MK :)
That’s a bit of a rose tainted view I think. Just as any “wisdom” system there is superb and horrible things.

Traditional religions were aimed at preserving a specific culture, things in line with that were nice, anything falling out of that would be shafted.
Check out humanism:
https://en.wikipedia.org/wiki/Secular_humanism

>Secular humanism posits that human beings are capable of being ethical and moral without religion or a god. It does not, however, assume that humans are either inherently evil or innately good, nor does it present humans as being superior to nature.
None of the people my age that I spent this past evening with (barring my own brother) were still using facebook. An account exists for all of us, but when its gone months or years without use, and there is no Facebook app on your phone, I'd say that user is lost.
You basically just send the offset when you resume the upload.
Cisco complained! That does so much... a customer getting a backdoored router doesn't really care if Huawei consented to adding the backdoor or Cisco didn't, they still get a backdoor.

Huawei says, in public, that it's important to their reputation to be known to ship un-backdoored devices. Cisco says the exact same thing.
Twelve steps to enable IPv6 in government and enterprise networks
Why don't you just use Windows with the included Ubuntu subsystem?

https://docs.microsoft.com/en-us/windows/wsl/install-win10
While true, I am not really believing Facebook had anything to do directly with that happening. It seems like the entire industry was moving that direction and WhatsApp would've always had to implement it.
Nice!

As someone who also wrote a GB emulator as a learning exercise, I found the sound code to be the worst part by far to write - getting sound timing right etc is very difficult (as the GB sound output changes instantly - it has no buffers etc)
When will people learn - 'secure the connections, not the network'. You don't trust the internet, and you shouldn't trust your internal network either.

Every connection between devices should be encrypted as if it's going over the internet. That's the basis of BeyondCorp, and many companies are going that way.

It's far more sensible to secure just two endpoints than it is to also secure all the wireless links, routers, and cables between them.

Now, when the adversary gets control of your routers, it doesn't matter - they can't steal anything of value. The worst they can do is cause a brief outage, for which they'll be immediately detected.
I know of a few people turning off IG and FB due to the volume of ads, when WhatsApp is monetized lots will do the same. Competitors can offer a similar experience to IG, WA and FB with less ads, because the margins are so massive for FB now, and their products are relatively easily replicated. It's VERY easy for user to switch to a competitor compared with other industries. The scale of the network is hard to achieve but we've seen this done a few times before so I don't see why it won't happen again.

I predict that FB will continue to push ads for short term profitability, slowly leak active users and find that a bunch of competitors will beat them by accepting a lower margin than FB are willing to accept.

The main hope for FB is that they can identify and acquire these competitors before they get a large enough network to take them out.
That is a very nicely formatted response.

It--- at least to me--- proves my point that active user is not a useful metric, as all of those people have very different values and drive growth (or don't) in very different ways, and so have no use being clumped together.

We didn't even get to talk about differing user demographics or time, data by country, trends inside countries etc.
Pretty sure OP is a passive user, and is extremely susceptible to better tools for OP's needs coming along, eg: the current crop of buy/sell/trade apps/PWAs out there.
In this case logistics cost will be more important, so factories closer to customers will win business
I don't think they are regionally oriented. If recent attacks on European aerospace intellectual property have shown anything it's that the Chinese government is determined to undermine any foreign technology sector that surpasses its own.
Actually isn't buying competitors a bad thing from the Anti-Trust point of view? If you own all the social networks and then refuse to let Influencers to share their post stats with their clients because "Facebook is not in the value chain" it really seems like it really becomes a real Anti-Trust issue. If you only own one, you can always claim there is competition.
The latter.

1. The client POSTs, this allocates a unique Location which the server returns and

2. the client saves this (e.g. in localStorage) along with local file identifiers so it can be looked up later and can

3. query that URL to check how many bytes were already received, and then

4. PATCH the remaining bytes

Repeat step 3 & 4 on failures/resumes.
At this point it seems most likely to me that the Bloomberg story was planted by the US government to sow FUD in a rival superpower. If this one Chinese motherboard had a tiny, quasi-magical chip (certainly technically possible but quite overkill as an engineering solution to achieve the alleged goal), can you trust any hardware purchase from China?
Religious values are values which already existed but proponents of religion decided to take credit for.
I'm fairly sure NCIS is doing stuff like this on purpose. Like the caf-pows that are always empty to the point of making slurping sounds fresh from the store or that time gibbs didn't know how to use an usb drive so he tried putting it in his mouth.
And Monads for All: The State Monad
It's their job to do these things
At the moment I have a 2013 MBP and I like it. I also read this was a good MBP year, but there were bad MBP years since then.

So, in the opinion of HN, what are good macbooks?
Gaussian Mixture Model Clustering
On the flip side, I have a solid GitHub and as far as I can tell, nobody on the hiring side has looked at it except for one guy who just saw that there was a lot of green. He didn't look beyond that though.

I've been given tests galore though. Last week I was given one and told while I was halfway through it that somebody had accepted an outstanding offer.

Hiring is so broken.
I did not know that, could you share a proof to back this statement ?
Audio: Download Elijah Oyelade Songs and Full Album – Dailygospelvibe
> 2018 pros: Trackpad is not mechanical

My 2015 MBP has a force-touch trackpad. Is the 2018 one substantially different from that?
You can't reliably fix this as a website. You can try to resolve this on the client by using the websites origin as part of the 2FA challenge (which is what U2F does) but ultimately there's no good, universal solution for this.

It's also important to note that 2FA was never meant to solve phishing, it was meant to solve password reuse. Phishing is still pretty much unsolved.
Flow maps: take for example an autonomous ODE

x'(t) = f(x(t))

f(.) describes a vector field, right? A flow map is a function w_t(u) = x(t) that solves the ODE with x(0) = u, for fixed t. If f(.) is invertible, then each flow map is a group in the very same way rotations of a Rubik cube are a group. If not, it's a semigroup, which is a group without an invertibility. The former describes systems that you can track back in time and calculate initial conditions only from looking at the present state.

My dissertation was actually about numerically integrating symplectic vector fields; I spent a lot of time hunching over Arnold's "Mathematical methods of classical mechanics".
I read EPAP should be a viable and cheap alternative, why aren't many people using it?
The serverless framework does not offer the best developer experience out of the box, that's why serverless boilerplate exists.
Yeah butwhatabout... (is the response here). You nailed it, either pick a 100% compromised device or a possible one.
Myth or not, the technology's been around for some years[1] [2], and there's a profit to be made from matching consumers and advertisers. One doesn't really need to run voice analysis, just pick a keyword[3] every now and then. You add two and two.

>would be a PR disaster for either company and cause legal action too.

Didn't stop Sony [4], and didn't cost them all that much in money - on the order of $1MM - or reputation either.

--

[1a] https://hackaday.com/2017/05/04/ultrasonic-tracking-beacons/

[1b] https://www.wired.com/2016/11/block-ultrasonic-signals-didnt...

[2] https://www.shazam.com/

[3] https://www.youtube.com/watch?v=9QTzVoaua4s

[4] https://en.wikipedia.org/wiki/Sony_BMG_copy_protection_rootk...
> All I know is that LaTEX is much, much easier to manage than this jumbled mess...

LaTeX is beautiful and powerful, but mixed with unicode (in the right doses) it becomes astonishingly more powerful. For example, you can keep the block constructors {} _ and ^, but use unicode symbols such as α, ∂, ∫, instead of \alpha, \partial, \int
Can’t find the direct coordinates for google earth, but you can see a couple images in the linked paper: https://www.cell.com/current-biology/fulltext/S0960-9822(18)...

Since they cover an “area the size of Great Britain” they would be extremely easy to seem from space if there wasn’t vegetation in the way.
Require use of U2F security keys for the second factor. The whole point of them is that they're unphishable.
Top 5 Intuitive Website Designing Trends We Saw in 2018
Finally a Request-For-Comments that actually contains a comments section!
Does that mean that the valuation of new companies in this space would be reduced once it becomes clear that the whole market is cyclical and by monetizing you start to kill your product?
8 Creative Ways to Make Extra Money as an Entrepreneur
I Implemented Single Step KDF from NIST SP 800-56C Rev1 in Java
Most of the big US companies embed US laws into their practices abroad too.

For example, making and distributing pornography with children is legal in about 20% of the world, yet no US-based international social media sites allow it, even the ones with an 'adult' focus.

We can't expect companies in other countries not to embed their host countries laws and customs into their products either.
PirlGuard – Innovative Solution against 51% Attacks
Facial recognition in China shames person on bus advertisement for jaywalking
here you go: https://www.google.be/maps/place/12%C2%B036'17.1%22S+40%C2%B...

edit: you can find the coordinates in the xlsx file they attached to the paper: https://www.cell.com/cms/10.1016/j.cub.2018.09.061/attachmen...
There's a fair amount of tools capable of manipulating a Git repo, not all of which are `/usr/bin/git`. "Everybody must use this complex CLI power tool, therefore people struggle" is simply untrue here, in the premise.