skysight-inc/HackerNews huggingface dataset:
It's effectively up to sheriff of the county wherein the applicant resides. The sheriff in San Francisco County wouldn't grant a permit if your life depended on it, not unless you're rich or famous. IIRC the sheriff in at least one rural county granted them as a matter of course out of principle, as if to spite the SF sheriff. As you say, in general rural sheriffs grant them much more liberally than urban sheriffs.

It helps if you know the sheriff or can be vouched for by someone the sheriff is familiar with. I imagine that in rural counties many middle-aged adults are only 1 or 2 degrees separated from the sheriff, anyhow, which suggests that rural and urban sheriffs are more alike then you'd think, especially if you exclude the two extremes; but the vast majority of people in urban areas will be too far removed from the sheriff's social circle. California's county-devolved permitting policies probably aren't quite as unequal and arbitrary as they superficially seem.
"Vastly increased health and intelligence"... again, you keep making assertions without any reference.
To preserve their main domain from the filthiest blacklists? So they can move on to another shady domain for dirty tricks if this one goes under in reputation. Executive thinking..
Humans are actually better at remembering names than faces
Apparently removing it may have other consequences:

> Even if editing worked perfectly, people without normal CCR5 genes face higher risks of getting certain other viruses, such as West Nile, and of dying from the flu. Since there are many ways to prevent HIV infection and it's very treatable if it occurs, those other medical risks are a concern, Musunuru said.
Though thousands of alleles contribute to intelligence, we would only need to edit a few hundred to get extremely large increases in IQ, especially if you perform a round of embryo selection (or even iterated embryo selection) before editing.

Editing hundreds of alleles may sound incredible to you now, but I don’t think it will sound so incredible for long.

Even ignoring GM, embryo selection can get us pretty far with current technology:
https://www.gwern.net/Embryo-selection
I'm seriously confused by what went down.

First off, why are the police even reporting this?

Secondly, what can the system even do? I'd believe a system could detect a person jaywalking.

Identifying them is a huge problem though. running facial recognition against a billion person corpus seems impossible (in fact what even is your match data coming from?). (?). Wouldn't you need to narrow it down somehow, perhaps using phone GPS records?
As one of the authors of the original paper the data is based on I have fond memories as a graduate student of standardizing the performance data to SpecInt which did not exist till the 2000s. So for the older processors that were no longer available I looked hard for processors that had both SpecInt and older benchmarks like Dhrystone and MIPS per seconds to normalize them to SpecInt performance.

The same data was used by other students of my advisor to create the Cpu database which has some more data like cache sizes and FO4.

http://cpudb.stanford.edu/
A few years back at a startup event I learned about SwineTech (https://swinetechnologies.com) as they're Iowa-based (as am I). Tech is everywhere, even in super-niche industries.
The semantic argument about how I phrased my agreement is more worthy of discussion than the ethical argument about the alleged human experimentation?
>diversify your industries and don't rely on one big player.

Isn't this what the subsidies are all about? If you want diverse industries to move to your region, you need some incentive to attract them.
Lol so they travel undercover and never stop any crimes? Seems like an unlikely scenario.
I would have switched phone companies that day.
This is interesting! What was valuable about these papers specifically, as opposed to the many written in the past 11 years?
For the surely upcoming discussion about pros and cons of genetic editing in humans, Kurzgesagt has a basic overview of the space, if you can spare some 15 minutes with your morning coffee.

https://www.youtube.com/watch?v=jAhjPd4uNFY

(not affiliated, just love their videos)
Setting aside the question of the impact of prices completely, the fact that Apple controls the sites that apps can link to should be abhorrent to anyone. At one point, they even tried to control what programming languages were used to write apps for iOS.
Even if it is an increase in price (debatable), that doesn't mean that Apple's distribution monopoly is responsible. I expect that prices on Android have done the same thing, and Google doesn't even monopolize the distribution there.
Dart was dropped by Chrome and Angular teams, rescued from certain death by the AdWords team.

Without something like Flutter, the language has nowhere else to go.

The judge is how there regarding how Flutter adoption is actually going to take off on the mass market, outside a few agreements to show off at keynotes.
I don't understand this. They don't advertise the pills as human flesh pills, so why use that material in the first place? Why not dead chickens, or runoff from an abattoir?
Well, he can tell his employees beforehand to only accept such order if he is in the US. Otherwise the documents should not leave the country. Then he would have to reply that he is unable to provide access to the documents.

Another reply suggested that he should have contacted the US embassy and ask that he is forced to commit a crime in the US by UK. This would have lifted it to a diplomatic level.

From the circumstances it sounds possible that he wanted the documents published and was happy to be forced.
It’s quite ancient and almost related to cult groups. Well, in some country it’s also part of its religion See https://en.m.wikipedia.org/wiki/Kuman_Thong. Should I tell you it’s very popular among celebrities?
The problem with micropayments is microfraud, which can be scaled up to large amounts. It's bad enough with ad click fraud already, and that's a semi-closed system.
And yet the countries that make obtaining guns more difficult are still much safer. It’s almost like if you rigorously regulate guns and have strict background checks, you can dramatically reduce gun violence... see Japan or Switzerland as proof where you can still own a gun but they don’t have mass shootings like we do here. And no, mental illness isn’t the issue. We have roughly the same amount of mentally ill as other countries, it’s the easy access to funds that explains the 10x increase in gun violence.
How to run a program without an operating system?
Most likely because it seems to be a phenotype that does not reproduce itself. None of Von Neumann’s children had kids if I recall correctly. This environment does not select for IQ past a certain point; this does not imply we cannot engineer people to be more intelligent any more than it implies we cannot engineer people to be dwarfs.
To be fair, that's part of the moral argument.
If it works and HIV resistance installed in a population, then it opens the possibility HIV could be then could become an effective bioweapon for that population.
oh wow. CCR5 has been found to have a role in memory recently. Knockout mice have better learning[1] and pronounced increase in spine formation/turnover[2]. These babies are going to have super-memory:

1. https://elifesciences.org/articles/20985

2. https://www.ncbi.nlm.nih.gov/pubmed/29379017
Not sure if you're asking about the role that academic journals play in general, or about what specific actions publishers do.

Journals in general serve to curate an ever-increasing body of research and provide a crude method of gauging scientific quality, relevance to your field, and importance. They provide a crude method of judging the impact of scholars without having to read every single paper ever published.

Publishers specifically put in grunt work to make the curation process function. That means hiring people to coordinate the peer review process, identifying new fields that are in need of new journals to help disciplines form and mature, ensuring standards of the scientific method are being followed, and of course there's the commodity service of hosting digital content.

I think a more interesting question is how much the role of a publisher is worth (as opposed to whether it should not exist), and whether there are ways to fill the same role with a cheaper alternative.
You're really in favor of Apple controlling what software can and cannot be run on your computers for convenience sake? Android allows multiple app stores and multiple browser engines and it hasn't caused the problem you fear at all. I can't think of a major app that is not available in the Google Play store.
The real incentive for cities is to encourage turnover, or at least not long term holding -- sales reset property tax to current market value. Even in 2010, in the depths of the housing bubble burst, most California counties were seeing growing tax rolls as turnover would reset to higher values more often than not.

I'm not an expert, but I would think that holding period for smaller, less expensive, 'starter' homes is shorter than larger homes. If that's the case, you want to zone for that. But, zoning is more about not upsetting voters than grand fiscal planning, in my understanding.
Looking at how addictive our interactions with technology have become this seems concerning. A future where we can all exist and never look up or leave our thought bubbles could have a dramatic impact on humanity and motivations.
"Superior IQs are associated with mental and physical disorders, research suggests"

https://www.scientificamerican.com/article/bad-news-for-the-...
remember also its an unborn child -- its not an experiment on the living, consenting adult.

child grows up, experiences whatever unknown consequences of the genetic experiment. thanks dad!
Seems like the lede was buried... the "acceptable" levels of RoundUp in U.S. food has been increasing from 100 percent to 2,000 percent.

"According to the EPA, between 1993 and 2015, glyphosate MRLs increased by 100 percent to 1,000 percent in the U.S., depending on the crop."

"Current MRLs for glyphosate range from 0.2 ppm to more than 300 ppm, depending on the crop. Between 1993 and 2015, the U.S. EPA glyphosate tolerance levels have increased by a factor of 50 for corn, and 2,000 for alfalfa."

So even without desiccation, we're still "allowed" to ingest several orders of magnitude more probably-carcinogen-related herbicides which screw with our cells and gut microbiome.
This will be a great tool to help game the social score.

More intelligence + less risk-taking + more respect for authority = a high-score child sure to get into the top University and have the freedom to travel there.

/s
This sounds super sketchy:

> He said the parents involved declined to be identified or interviewed, and he would not say where they live or where the work was done.

> There is no independent confirmation of He's claim, and it has not been published in a journal, where it would be vetted by other experts. He revealed it Monday in Hong Kong to one of the organizers of an international conference on gene editing that is set to begin Tuesday, and earlier in exclusive interviews with The Associated Press.

To be honest, _if this is true_ it sounds like he modified them without the parents knowledge or consent. Usually, I'm super skeptical of any "research" coming out of China. However, I've suspected that China has been doing this for a while anyway (without sharing it). So I'm left with three possibilities in my mind:

1. Government is releasing this to see how the world will react

2. The doctor excited to share their work, shared it - but did the work without the parents consent

3. Parents did this knowingly and in a controlled way

Of those options I'm betting #2 followed by #1. Highly doubt even if the parents consented this was entered into with the knowledge of the risks. Seriously if they are using Cas9 who knows what else could go wrong.
> I don’t want to have to keep 5 different app stores installed to have access to everything.

The nice thing about F-Droid is that the repository format is open. So you only need one "app-store" app installed (F-Droid), then add multiple app sources that are each controlled by some app curator. For example, the "F-Droid repo", the "Guardian Project repo", the "copperhead OS repo", the "micro G repo", etc etc. This allows for a unified user experience without centralising app execution power in the hands of one organisation.

If you've used GNU/Linux this is exactly how package repos work (and what F-Droid was inspired by), since several decades before the term "App Store" was invented.
"What is the relevance of "Asian nations?" to this conversation?"

I would assume it's because the article describes genetically-engineered babies in China, so obviously it's not outlawed there (or if it is, the law is not enforced). Grandparent poster is pointing out that if genetic engineering gives survival or competitive benefits to those who do it, it doesn't matter what your personal ethical, moral, and legal standards are, because your whole society will be outcompeted by societies without those strictures.
Tests of General Relativity
I sometimes agree to review out of a sense of obligation, where I know damned well that the authors recommended me, but you’re right, that’s not networking per se. There’s no reasonable expectation of benefit and it would be unethical as hell to request any.

The authors most likely won’t (can’t) ever know that I agreed to review their paper; it’s more of a good citizen affair. Sometimes, afterwards, it will become apparent that a particular referee was someone familiar. I would like to think that the original poster was imagining something along those lines, but your take is probably closer to the truth. Oh well.
Just going by my memory of what they advertised. Here's a TSV with some public salary data from 2012:https://gist.github.com/shabbychef/5915640
Not my area of expertise, but I think the intuition for why evolution didn't make us all Einstein's comes in two parts:

(1) IQ is very polygenetic - a big IQ gene might be 0.1 IQ, and there aren't a lot even that large, if I recall the large genome wide association studies done on this. As GWAS studies get larger we find more, but they're all super small effects.

(2) Having an extra 0.1 IQ point is easy to lose in the noise of other effects on having offspring.

So even if we assumed IQ was perfectly correlated with more surviving offspring in modern societies, it might take an extremely long time (even longer than a whole planet and a thousand years) to make a detectable difference.
I can't find my own calculations but it was about 50% of an ICE car, even accounting for coal.
Also this - I review for journals because in turn my submissions to those journals are reviewed.
كيفية الحفاظ على بطارية هاتفك
Play around hr. Network.
Arbitrary Image Stylization in the Browser
which part is unethical though? it was voluntary
> I mean, your PhD advisor will make sure you never challenge the research status quo with your thesis topic

This will come as a surprise to both my PhD advisor and my current advisee
Your quotes also highlight the possibility that this is all fabricated.
For an algorithm with "standard" in its name.

This gets more confusing my the minute.
Because it requires medical experimentation on human beings who can’t consent to it. Is it really so difficult to understand why that’s wrong?
Thanks for that super weird article. The author's motivations for supporting China's eugenics efforts are puzzling for sure.

Thankfully we might be safe for the time being. IIRC the BGI IQ sequencing initiative did not lead to any meaningful discoveries since it's not yet obvious or fully proven yet that IQ is that heritable.

My 50c is that we as a population have currently stopped evolving regions of our genome that can keep resulting in progressively higher intelligence, for two possible reasons: 1. there's some evidence at least from my view that any further increase in intelligence will cause other side effects like depression and autism (or perhaps a more intelligent version of us cannot unsee the futility of our lives?); 2. It's not in the interests of the population as a whole to continue having a fight between individuals having heritably different IQs, i.e. we have evolved into a local minima so that all IQ differences are stochastic and it's really hard to leave this minima through mutations.

I think the second possibility makes sense because intelligence is such a huge evolutionary advantage that a population with high instability in this trait might be doomed (more intelligent people can cheat more easily for short term personal benefit at the expense of long term population benefit). I really think that one of the first things modern humans evolved was the genetic ability to make sure that intelligence was completely randomized among the population, and I now hope that's true also because of all these efforts because if it's true none of these efforts would succeed for a long time.
and that should not be enough.. We should demand responsible behavior and institutions should reward those capable to think in the long run.
Just checking: you do know that there is a difference between change of "5 standard deviations" and change of "5 IQ points". 5 standard deviations is equal to "1 in 3.5 million", which makes your claim fairly farfetched with the tech of today or of the future decade or two, especially given how IQ is much more function of nurture than of nature.
Historrically inteligence has been a trait that had to be balanced with other factors in natural selection, traits such as having lower energy consumption, lower reaction time were important in the past in a way they simply aren't today. Sacrificing in other less relevent areas could easily lead to intelligence gains.

(Note I am not advocating for gene editing)

Also I don't think we have reached a local maximum, human society kind of fucks with natural selection so I imagine there is room for improvement.
> Folks here on HN are (understandably) leaping on the notion that this will force Apple to allow other app stores

I'm leaning in quite opposite way. Apple enforces security and privacy policies of its store apps, which is main reason why it is much safer to use than Android.

As for app prices, Apple Store is an open competitive market, no apps are restricted to compete. I see the point being moot. Adtech industry would love to see Apple lose though, don't let them.
Thank you. This is such a great resource and very readable on mobile too since it's just txt like a man page.
Okay, I used to be an iOS user, I'm not rich, and blowing $99 per year to sign apps is a lot of money for something that should be free. What if I'm just a normal techie who wants to use software that Apple doesn't like? Sure, bury sideloading in the settings or make it only able to be activated from a computer, but charging that much money for the privilege of loading software is ridiculous.
We got a point system in The Netherlands. If you get too many points, you lose your license. However it only counts for new drivers. Which doesn't make sense at all, as its elitist towards the older adults.
How can I contribute to OpenStreetMap? (currently spending a few 5-15 minutes chunks of time on Google Maps)
It was intended to replace zlib/DEFLATE as the de facto standard of casual compression algorithms, so it makes some sense.
A Week in New York City on a Joint $400,000 Income
Kubernetes the hard way: https://github.com/kelseyhightower/kubernetes-the-hard-way

Gave me the necessary understanding of the core layers of a cluster.

The Digital Ocean docs were already mentioned but they're also an exellent reference source.
Show HN: Unit Circle Visualization in Elm
PKD's electric sheep was one of the first things i read "online" -- via BBS baby
Exactly. What happens when these babies become toddlers or young children and they start contracting all sorts of weird cancers.

See article: Potential DNA damage from CRISPR has been ‘seriously underestimated,’ study finds

https://www.statnews.com/2018/07/16/crispr-potential-dna-dam...

The results come hard on the heels of two studies that identified a related issue: Some CRISPR’d cells might be missing a key anti-cancer mechanism and therefore be able to initiate tumors.
I can't speak for the above commenter, but in a way street people in SF really are more free than employed people. If I were to break into a car and steal stuff I'd get jailed and released a couple days later, or even the same day. But I'd probably get fired. Whereas someone with no job would get jaled and released with no real consequences. Because the city refuses to enforce many crimes (basically, anything short of significant violence) beyond catching and releasing, the only thing keeping people in line are their employers and peers. And if someone doesn't have a job and their peers don't care about committing crimes, then a whole bunch of stuff becomes de-facto legal.
> Subsidies have never worked.

I'm skeptical of this, but I don't know that it's wrong. I'm only making this comment in hopes of somebody else more knowledgeable responding to it (either for or against - really I am just curious if subsidies work).
>our current moral and ethical frameworks.

Clearly those moral and ethical frameworks are not shared by at least one Chinese scientist.
Unsigned are not broken by default, and I've been bitten much more by ints that overflow and go negative. Funny how that's not "broken by default" (it isn't) to the same people.
I used to think like that when I was young. Then I learned I was short-sighted, and that every time there are traffic rules (including speeding) they (almost) always make sense. Sometimes they don't, true. If you then have contacts within the (local) government they love to get proper feedback from citizens.

To give an example: there's a school nearby where the sign says 30 km/hour. It is an important road people who live in my neighbourhood, connecting them to their home (commute, shopping, etc). I drive on my bicycle crossing that road. Do I assume people drive 30 km/hour or 50 km/hour? Cause many people drive 50 km/hour there. When kids go to/from school people might drive 30 km/hour, I don't know exactly how that works. Many might not even know there's a school there. Even though the sign says there is, perhaps that gives the mental note: "..but it is Saturday." If we're going to arbitrarily ignore traffic rules whenever we see fit, it is going to lead to chaos.
The test confirmed GR. In particular the test results contradict theories with massive graviton and theories with "gravitational leakage" into the large extra dimensions of higher-dimensional theories of gravity.
That typically works when your works are mostly visual and the position takes that into account. Most hiring managers won’t bother reading a single line of code.
HTML apps are never even close to working as well as a native app, they're generally a shitty compromise. If $COMPANY makes an app that would be crippled by Apple's policies, they should be free to distribute it through another channel to iOS users.
What you are saying is just not supported by evidence. For example, polygenic analysis of the latest meta-analysis from >250K individuals seems to say that the top several hundred variants explain in aggregrate only 5.2% of the variation in intelligence. Source: https://www.nature.com/articles/s41588-018-0152-6 (Supplement section 2.3.3 if you don't have access).
Hear it from He Jiankui himself: https://www.youtube.com/watch?v=th0vnOmFltc
>What those high fees really come from is the need to cover the cost of all those rewards programs

You've swapped cause and effect here. It's the other way around.

High fees lead to rewards programs.
I am aware of this. Genetic engineering implies far more power than Gwern mentions for one round of embryo selection. 5 standard deviations may sound a lot for you, but in animal breeding we have changed the distribution of various traits by far more than 5 standard deviations. Into the dozens.