skysight-inc/HackerNews huggingface dataset:
It looks like the work they were given supports the cas9 issue you were mentioning:

> Several scientists reviewed materials that He provided to the AP and said tests so far are insufficient to say the editing worked or to rule out harm.

> They also noted evidence that the editing was incomplete and that at least one twin appears to be a patchwork of cells with various changes.
This must be a candidate for an igNobel.
I believe that privacy is key to digital currency. It should be opt out such that government spending can be tracked, but by default it should be private. Without privacy, I don't consider any digital currency to be fully baked.
Your system is safe from the arbitrary code. The article points out that WASM makes it really hard to catch memory bugs inside the app itself even though these bugs can't escape the sandbox.
On average, Dutch farmers tend to use the least water per mass of product sold.
Five Years as a software engineer
The dictionary is only useful in independently compressing lots of small data chunks. Tiny files, rows in a database, VCS commits kind of things where each is independently compressed and extricable. If you tarball them so you're compressing ~100kb+, there's really no benefit to the dictionary step.
Check out https://killedbygoogle.com/ if someone says its not dead, that means it is already dead.
These are nice. Thanks!
Very few tenure committees, funding agencies, etc. give equal weight to an arXiv pre-print and a published paper.
Is it really though? I feel like Americans regularly say things like this (guns is another similar topic) which only reflects an inability to think many steps down the line from the outcome. There is something deeper at play and I would suspect that it has to do with economic insecurity and lack of opportunity which is further compounded by a lack of education and social cohesion in general. American values are all wrong. You only need to look at the Black Friday mayhem for an example.
Very much off topic: 3.6l is >2 times more cylinder volume than useful in >95% of scenarios.

Pick your favorite reason to minimise your crude oil consumption. Global warming and not subsidising oil despots are two good ones to me.
Re the “without consent” part of #2, is it hard to get some parent sign the agreements, even outside China?
Currently on front page: https://news.ycombinator.com/item?id=18530906
It's so projects that are licensed under either of GPL2 or BSD can use it - so there's no worry about license incompatibility.
In addition, even with that much or more explanatory power, we generally do not think we have necessarily identified causal variants in most cases. We identify groups of associated variants that signify an interesting locus. There isn’t currently a generic framework that lets us decide which ones are causal.
Apple do offer iTunes Credit and often does discount of up to 15% from Retailers. ( I am betting those iTunes Credit are wholesale at anywhere between 13% to 10% discount, and Retailers takes in ~10 - 8% after deducting processing fees )

Still, not many buy iTunes Credit. Most just use Credit Card direct from Apple Pay. But even if we have included all these, the 30% is still excessive.

The problem Apple is having is similar to their phone, it is not about the price tag or the 30% charges, it is people paying for it fail to see or justify its value. Apple will need to offer more "values". From Developers to its Users.
[Release v1.2.2]A high performance, distributed RPC framework
There is no human with all the positive variants; it is the the distribution of these variants that explains 5.2%. GM would allow you to create such a human.

That paper does not imply what you think it implies: that editing all these variants in an individual embryo would have a small effect.

An individual with the top 200 IQ-enhancing variants edited in (and an otherwise normal genome) would be far, far smarter than than than you seem to think, even though the variants edited only explain 5.2% of the differences within the population.
How to Model Viral Growth: The Hybrid Model (2012)
Since the use of a quantum-theoretic framework is for modeling purposes, the identification of quantum structures in cognitive phenomena does not presuppose the existence of microscopic quantum processes in the human brain. [2]
Not dead doesn't mean useful. Best case, it is providing partially correct information.
What is your evidence that the post-WWII flavor of bioethics inhibits real progress? If that were true, why do we not see other systems leading?
> The solution to fines is to simply get rid of fines and instead use a more aggressive "point" system.

You're assuming the problem that fines address is modifying driver behaviour. It isn't. The primary problem fines address is revenue.
Of course it's corruption (in this case, Jerry Brown and Willie Brown and their minions being the primary drivers).
The problem is a way to send censorship resistant financial transactions.

If you don't find this to be useful, then you should consider yourself fortunate and privileged.

In the same way that if you do not need TOR for your life, then you are also fortunate.

But there are literally billions of people in the world, right now, who are living under what I'd describe as authoritarian regimes.
Neat!

Since the "Star" button isn't clickable, here's a link for anyone else interested in the source: https://github.com/aesakamar/unit-circle/
Discussion on front page: https://news.ycombinator.com/item?id=18530906
Interesting. You don't encounter people who hold triple citizenship all that often here in the US.
Ahh I see, you are just making stuff up.
So what? People don't do this deliberately very often because there's always the risk that the driver doesn't stop. If you try edging into the road you'll get honked at.

The concept of jaywalking has never made any sense to me as a Brit; it's like that joke sign meme of "Danger of death and £20 fine".
It seems to me those domains lack a well-defined paradigm that can be taught in a easily digestible way in a classroom environment.

I imagine some of the known valuable skills can be taught to a certain degree. Problem-solving, learning how to learn, assessing opportunities, looking for inefficiencies, communication, telling a compelling narrative, and so on. But I don't think it is easy to teach those things in a highly effective manner, at least not in a short amount of time.
And we can find people who disagree with the broad consensus on climate change, too. Is there a broader point you are getting at?
This could explain why the scammers were able to claim the bank listings.
The two banks mentioned in the article are nationalised(govt) banks, notorious for unprofessional work-culture. (I have an account at SBI)
I wouldn't be surprised if the emails from Google went to black hole email addresses, giving scammers ownership of the listings.
BEAT: asynchronous BFT made practical
"Good but error prone" seems to aptly describe our current method of producing offspring.

Gene editing is mandatory, if only because we've managed to turn many previously lethal mutations into livable, and reproducible, ones.
Not saying the conclusion is wrong, but that experimental methodology seems sketchy as hell. Why? Their sample consisted entirely of Mensa members. Mensa != the general population of high-IQ individuals.

You join Mensa if your IQ is a large part of your identity. Individuals who have a high IQ but also have a lot of other things going on in their lives (like career success or fulfilling personal relationships) tend to concentrate on those things rather than join Mensa. Therefore, membership in Mensa tends to overselect for individuals whose self-conception is both narrow and focused on their intelligence. There's a lot of other evidence in psychology that a narrow self-conception correlates highly with mood & anxiety disorders. You can also get correlations with physical ailments like environmental allergies and asthma as well, because someone who doesn't have these physical ailments is more able to get outside or pick up sports rather than go to meetings of a high-IQ society.

So the way they designed their experiment, they introduced tons of conflating factors that may or may not actually have anything to do with IQ. It's certainly possible that high IQs are associated with mental and physical disorders - but what the experiment shows is that membership in Mensa is associated with mental and physical disorders.
That logic makes some sense in rural areas where it's a safe assumption that many, if not most, homeowners are armed. Where I grew up, anybody thinking of breaking into a house or even of trespassing had to contend with the very real possibility of being shot at; not only were guns common, but many people kept them loaded and readily accessible.

But in areas where few law-abiding citizens are armed and most people have no inclination to arm themselves, all lax gun laws do is put more guns in the hands of high-risk individuals. In most of the incidents discussed in this thread pepper spray would have been more than sufficient to thwart an attacker, but nobody is carrying that, either.

It's also worth pointing out that in rural areas you're rarely in a situation where you're in physically close proximity to potentially dangerous people. I suspect both urban and rural folks are similarly averse to escalating violence, but there's much more ambiguity in urban environments, which explains why people don't even bother carrying, let alone using, pepper spray in cities, whereas in extremely rural areas people keep loaded shotguns in the corner. That and violence is much less common than we believe, and we actually behave accordingly even though we say that we feel unsafe. The calculus is the same in both urban and rural areas, but the input parameters produce wildly different results.
well, its just unethical based on USA rules against human experimentation. obviously moral and ethical codes can evolve to accommodate advances in science eventually.

this is not a medical procedure, which is what makes it unethical to perform. its an experiment with unknown outcome which is why current ethics dictates it is not okay to do this.
Eviation’s Alice is an all-electric, nine-person aircraft
> ...for something that should be free

What reason should it be for?
The Reddit thread

https://www.reddit.com/r/MachineLearning/comments/9jhhet/dis...
There are literally millions of healthy people without CCR5 receptors. (Millions is approximately 0.01% of world population and this mutation's frequency is certainly greater than that.)
Please consider watching (or reading) this talk. If you are interested in how a modern Game ECS works and why indeed OOP often isn’t the way to go: https://kyren.github.io/2018/09/14/rustconf-talk.html
Of course you shouldn't be forced to use certain payment methods. ut that is irrelevant to the choices of other people.

If other people want other payment methods, that is their choice.
content appears to be plagiarized from

https://www.worldatlas.com/articles/the-2008-stock-market-cr...
The cap and trade system was done away with by our current government in a populist bid to "reduce the price of gas" (and unsurprisingly, gas prices didn't change with the removal of the program).

Our Hydro prices are about middle-of-the-road in North America. We have a tiered-use system that sees prices as high as 13.2¢/kWh On-Peak (during the day) and 6.5¢/kWh Off-peak (at night), with an average around 8-9¢/kWh IIRC. Far from expensive, but when everyone compares our prices to Quebec (one of the cheapest in NA and is something around 4¢/kWh average IIRC) it seems astronomical.

Labour rates generally aren't too crazy either, we do have a relatively high minimum wage of $14/hr, but when unions start to run the show and wages become "competitive" it starts getting out of hand. Cami is in my hometown and IIRC the average employee takes home something around $35/hr. Toyota in Woodstock and Cambridge are over $35/hr at their highest rate, even though they aren't unionized, but they still have to pay competitive wages or they'd never have enough employees. A lot of the feeder plants (i.e. the places that make components; engines, doors, etc) are in the $20-25/hr range and they have an astronomically high turnover rate, nobody wants to do the work unless there's huge money involved. I'm wondering if this is the reason; why pay thousands of ungrateful employees >$30/hr for work that can be done for <$10/hr virtually anywhere else on the planet? Even by the time you factor in the costs of shipping vehicles it's gotta be thousands of dollars cheaper per-vehicle. It can't be easy to justify the cost to shareholders unless the (monetary) benefits massively outweigh the cons
There is a lot to unpack here. But this is basically science fiction, given how far out we are from understanding how to cosmetically modify complex traits in this way.
I have to disagree where 30% is a low margin. This is different to real estate where there are actually foot traffic in front of your store. The App Store is more like a nation charging 30% tax regardless where you live, and that is on Revenue not Profits.
content appears to be plagiarized from

https://www.worldatlas.com/articles/what-is-the-non-aligned-...
Fair enough, makes sense.
Saw a talk on Include OS that is a C++ library that allows one to do this
http://www.includeos.org
A good point. Most people would spend many thousands on a smartphone given how useful they are, but yet we don’t have to.
Agreed, the architecture diagrams I usually look for are high level, mostly about how different systems are connected. These don't change that much.

When looking at architecture diagrams, usually you don't want them lower level details anyway, they would just obscure the big picture.
> it has zero business being used to run arbitrary code that's automatically downloaded from the Internet

That has always been the very nature of the web.

Web Assembly, like other web applications, will be executed in a sandbox separate from other things. Isolation alone does not make it safe, but it does prevent corruption of other things.

This is why many websites execute advertisements in an iframe, because the code that comes across is not trusted and often not safe. The unsafe code will still attempt to stalk and/or attack the end user, but the iframe prevents that malicious code from corrupting the serving page. There is no reason expect anything different from WASM.
1. no one uses this outside of china,they failed in their push to even india

2. global leader right now

3. as compromised as whatsapp,has data compliance with multiple countries

4. no name fork of a no name
See that conciseness I don’t see as a benefit. I do acknowledge the downside of having a query in a method and maybe having to tweak the same type of query in a handful of methods any time the schema changes. It’s a good way to introduce bugs I guess. At that point I would just use stored procedures.
We do. In China. Not just in biology but also AI/ML. They are willing (and able) to do the things others find reprehensible.
It's already apparent just how far ahead they are in the AI/ML field, I suspect biology/medicine will follow.

It's a very real threat and believing that The West has a head start and is more intelligent/better funded/other excuse is not going to end well for us.

China achieves goals though brute force with very little regard for ethics or norms.
Youve missed the most important usecase. Censorship resistant financial transactions.

If you don't find that useful, then you should consider yourself fortunate and privileged. There are literally billions of people in the world living under authoritarian regimes right now.
How would it do consumers good?
While agreeing to the general principle, incentive structures are wired quiet differently in academia vs end consumer oriented gig/service industries.

Publications ( number, when, where, citations) is the primary currency/value in which one is judged within the peers in academia, and reputation outside the immediate academic community has a much lower weight. Whereas for online market places solid revune is the first priority and then comes reputation ( which is a means for the higher reveune). In academia it is the reverse, with reputation ( in a small clique) being the primary motivator, and funding being the means to gather it.
The AP article does state that Michael Deem (Rice) was there for the consent.
Content appears to be plagiarized from

https://www.worldatlas.com/articles/what-is-bitcoin.html
> Seek collateral on the company via shares or some other valuable goods that are not easy to shed.

As part of the bailout, Canada/Ontario took a 12% ownership stake in GM. They have since sold their shares (at least Ontario has). At the time, the union president argued they should be keeping the shares for that exact reason, so that they have a reasonable influence on company decision making.

https://www.theglobeandmail.com/report-on-business/ontario-s...
Isn't socioeconomic oppression kind of the point of all this, though?

It's not just the implementation of the justice system that needs correction; it's working exactly as designed. We have to change the entire design, not the little implementation details.
How to turn $1 into $44 just only sending emails?
Yeah, sorry; I was mostly going off my own past knowledge when less was known; There's a nice summary here as well: https://en.wikipedia.org/wiki/CCR5#Potential_costs
> Why don't people just publish through Arxiv?

ArXiv is not peer reviewed.
Phytoplankton is already declining:

> We observe declines in eight out of ten ocean regions, and estimate a global rate of decline of ∼1% of the global median per year. Our analyses further reveal interannual to decadal phytoplankton fluctuations superimposed on long-term trends. These fluctuations are strongly correlated with basin-scale climate indices, whereas long-term declining trends are related to increasing sea surface temperatures.

https://www.nature.com/articles/nature09268
I agree with you tbh. Considering the tremendous false positive rate with sniffer dogs too, I find the use of them especially hard to justify as anything other than intimidation.

Got to remember though that when police do big operations like that, they may also often be looking for one specific target/individual, but have to use a blanket approach to apprehend them. So while you may be caught up in the "random" checks, they may just be using it as a facade to catch a truly dangerous person.
If you ever programmed a ROM for a Gameboy or something this should look familiar. The BIOS of those old systems just jumps right into a certain address and all you have to do is make sure your linker is setup properly to put crt0.s there.

The Gameboy Advance in particular is pretty fun and simple, I recommend it.
I'm not sure people are trying to fix academic publishing so much as burn Elsevier to the ground. Whether or how they are replaced is a separate question.

https://www.talyarkoni.org/blog/2016/12/12/why-i-still-wont-...
Storage/hosting, support and distribution (bandwidth) are missing frim the list. Arguably, it may not cover 30%, but it does provide for more than 2.9%
Linked earlier at https://news.ycombinator.com/item?id=18518302
If a few dozen or even thousand suffer to prevent the suffering of many millions or even billions in the long run, is that not a trade off one would have to make?
It all comes down to the old debate of deontology vs utilitarianism
hmm, does it work vice-versa, i.e. `if someone says dead, that means alive and kicking`.
More likely that the most popular regional telconf software has a bug that dumps an uncleared buffer into the wrong call on some edge case.
Since littering means degrading the appearance of a public space for some amount of time, it's hard yo put a price on it: the maximum fine should be the cost of a person assigned exclusively to you, who immediately picks up whatever you throw to the ground and nicely dispose of it in the appropriate way.
What you say would make sense in case of unpaid fares. In the case of speeding, there is no amount of money that can offset the increased risk to pedestrians and other cars.
SF is a city for the rich. I used to think such an idea was ridiculous - a city that only accommodated a single class of people. But having a single city without affordable housing doesn’t sound so crazy to me anymore. Whether or not a city wants affordable housing is a choice.

Honestly I’m not sure what changed in my opinion. I’m generally very pro-building, but I realize different people want different things.
In order to show that the engines are wastefully large, you first have to show how a smaller engine provides better fuel efficiency over the 95% range, and then show how the remaining 5% is unimportant. For example, if the big engine is 5% less efficient over the power range of the little engine, but the increased max power it provides allows you to accelerate out of getting stuck in the snow, or travel at safe speeds up mountain roads, reasonable people might decide that the trade offs are acceptable.
> no apps are restricted to compete

Apps are restricted from competing on price. I can't release a 79 cent app to compete with a similar 99 cent app.
The bailout of GM, accomplished three things, the first of which - it saved the myriad of suppliers (ecosystem) the automakers need to make cars, the second was saving and unknown amount of money from unemployment claims by workers of GM, and downstream suppliers - in addition to money the pension benefit guaranty corporation would have paid out to cover GM pensions, it also preserved around 35 billion in tax revenue. While I'm opposed to bailouts like this on principle, letting an intire industry die, because one dominant player fails - the collateral damage trumps pricpleded thought here.
Facts are not opinion. Morals and ethics however definitely are.

You can show with empirical evidence that climate change is true.

However no matter how hard you try you can't show with evidence that your moral framework or ethics are somehow the "one true moral/ethical truth".
I’m going to save eigen-face as a pocket insult the next time I need to call someone generic-looking.
No. I think the claim "one can raise IQ several standard deviations by editing <200 alleles" is likely true:https://arxiv.org/pdf/1408.3421.pdf
Some fun tidbits in there.

Amazon's original business plan: "No warehouses, no stock, no shipping"
Author of the Airbnb blog post here. Airbnb is fully invested in 100% native right now.
An outcome of cryptocurrency would not be elimination of artificial recession as evidenced by the repeated losses of 75% of value practically overnight. Seriously, do you even understand the words you are saying or are you just blindly parrotting something you read on the Internet?
Notes on how founders can hire big, hint: think big
I only abide with one rule - the documentation that you would create, whether diagrams, contextual model, or any artifact related to the software should be something worthwhile to read. Otherwise, it all becomes a meaningful assumption with zero audience.
You need causal variants to do editing, but tagging variants are sufficient for selecting.
Sometimes there is just no right way when it comes to using OOP. Sure OOP is often a hammer that will make everything look like nails, but for some problems it really just isn’t the right approach at all.

For a very good example when this is indeed the case, watch (or read!) this amazing talk by kyren on Game ECS: https://kyren.github.io/2018/09/14/rustconf-talk.html
>frankly fraud only matters for large transactions.

Maybe in the world of the wealthy.
How does OsmAnd handle traffic? For my commute I religiously use Google Maps to learn about accidents or other blockages to make my trip shorter. Can I do the same thing with OsmAnd? (I'm thinking no, but I'm unfamiliar with how traffic data really works, so I'm open to learning that I'm wrong.)
no one really uses RSS anymore imo, i just "subscribe" to the author on twitter - that way i get more interaction than just notification of articles