skysight-inc/HackerNews huggingface dataset:
> Let's say your drug's price of $1m compares favourably to $100k/year for 40 years to manage the disease. How can a company who might only be covering the employees for 1-3 years be expected to cover that higher cost?

Yes, it's essentially a Prisoner's Dilemma. If every insurance company agreed to pay for this drug, the total cost of treatment overall would be lower (and the patients would be healthier and happier). If my company decides to pay it and no other insurance company does, then when the patient leaves our network (in less than 10 years) and joins another insurance network, my company will have paid the cost but can't reap the financial benefits.

There's two major differences between this scenario and classic PD, though.

First, companies are allowed to communicate. We could conceivably get everybody in a room together and come up with some agreement by which everybody agrees to pay for this drug, even if patients switch insurers. Everybody wins. Patients are healthier, and insurers save money.

Second, it's not a one-time decision. An insurer can change their mind from "no" to "yes" at any time. So it's more like "iterated PD", with an indefinite number of rounds. In that game, interestingly, there is no strictly dominant strategy, and altruism tends to do better in practice! So maybe you don't even need an agreement.

> To be clear, this is further evidence of how stupid the US model is. In a single payer model this particular concern goes away.

How do you figure? The article points out that they also had trouble convincing European governments to pay for it. You can't get Glybera anywhere in Europe or Canada today, either.

The US model is arguably a poor one, but this isn't a good example of that, because every other country in the world failed at Glybera, too.
Same here. I use Thunderbird via IMAP and gmail hasn't slowed down at all in the last 10 years since I've been using it. I don't use their webmail interface or gmail branded mobile app either. Email is email. Use an actual email client.
Worse than Subscribe popups?! Are you crazy?! Oh wait, I said that. :-)
I just always use the "CMD-Up" shortcut on Mac so the "Back to top" buttons feel like visual clutter once you've learned the keyboard shortcut.
NFS is widely used in HPC to mount user home directories on compute nodes.
I migrated to mu offlineimap, emacs and mu4e for my gmail. I'm quite satisfied.
AI in Drug Discovery – A Practical View from the Trenches
They're also usually limited by duration. So it'll be x euro a night for the first 7 nights, with a max of Y per stay
> Random side note: on MacOS, the kernel does know all the filenames of a hardlink, because hardlinks are secretly implemented as fancy symlink-like data structures. You normally don't see any symptoms of this except that hardlinks are suspiciously slow on MacOS. But in exchange for the slowness, the kernel actually can look up all filenames of a hardlink if it wants. I think this has something to do with Aliases and finding .app files even if they move around, or something.

I don’t think this is true anymore with APFS.
I went from a software engineer to starting my own CBD company. Most of what I do is sales now. Making the transition has been very difficult. It's a completely different world.
In an episode of the anime series "Food Wars", the main character basically does this at the restaurant he is assigned to internship at.

He and another chef student are assigned a local restaurant which is regularly and completely swamped by commuters; commuters flood the restaurant, everything is crowded, kitchen is over crazy, and then everyone evaporates to catch the next train home. Every day. Local eaters be damned. On the surface business is booming [daily rush of commuters!] but in reality there's a struggle.

Main character figures to go "reservation only". Walk-in commuters not allowed unless they have a reservation; no walk-by "I'll grab some sushi". Owners freak but are desperate... and things work out. A local comes in for his reservation and comments how he hasn't been able to come by for months because it's always so crowded, but he's oh so happy that the waitress remembers his regular order. Restaurant survives and within sanity.
I very clearly did not ask who avoids travel because of total costs.

The question is in what case does somebody avoid booking a trip that they otherwise would’ve taken because they just can’t stomach the tourist taxes once they’re already paying hundreds for flights and lodging?
What's the status of their efforts to recover and recycle the payload fairing? I remember reading that they expected to save $1M or more per launch by doing that.
can you share a link to your site?
Sorry, but that's my call, not yours. My computer is not a nuclear power plant.
Maybe I'm just naive thinking it could work, but have you tried /u/autotldr?
I've never seen a definition of a startup that I like. Here's my personal sniff test... To me, a business is an entity with paying customers. To me, a startup is an entity that wants paying customers before it has them, or has them now but once did not (and it remains a startup until people stop calling it that).
Could you say what is "Cloud PA" here? I'm not familiar with this term.
I doubt it's over. Facebook has their constellation of of apps and services. And the cost of switching is not so simple for, say, the average user who's used facebook as their photo and video archive over the years. But most of all they have the opportunity to pivot, reinvent themselves to keep relevant. Something I wouldn't count them out of. Personally, I hope they fail. The last two years have seen my feeds turn into majority hate filled posts full of vitriol for some issue or other. Only a minority seem to actually be relevant for keeping in touch with friends and loved ones.
How about a giant space seesaw?
Directors Claim Small Victory in Bid to Save Classic Movie Service FilmStruck
They couldn't decrypt, but as a CA, like any other trusted CA, they could man-in-the-middle the traffic, read it, then pass it along to your server, re-encrypted.
You must have a lot of mice? I've had great luck with these: https://www.homedepot.com/p/Tomcat-Mouse-Snap-Traps-2-Pack-B...
I have a similar take on the incentive misalignment with fakes + store brands.

Two counterfactuals to consider:

1. For this to be true, consumers will have to know Amazon is behind the brands. Works for AmazonBasics, but the ones in this story I'm not so sure since their providence is a bit buried.

2. Fakes appear more often in higher-end products. Store brands (like AmazonBasics, Kirkland, etc) are typically geared at low/med end of market.

Both of these hinge on brand perception. If Amazon can improve brand perception of their store brands, they're going to be more willing to say 'these are Amazon brands' on their listings. And the more they can do that, the more incentive misalignment exists on fakes. I don't think 'these aren't fake' is enough to improve brand perception alone as quality matters a lot, but it probably does contribute.

Of course, every retail category is different. I imagine there are some categories today where the intersection between fake problem + Amazon brand means the incentives are aligned to soft-pedal any real progress on fakes.
1. It only takes months if your satellite uses only ion engines. If it has regular hypergolic propellant engines it only takes hours.

2. ULA's (Lockheed Martin and Boeing) Atlas V and Delta IV can make direct-to-GEO insertion, and basically only the DoD wants that. SpaceX plans to use FH to get DoD contracts, but it's not a very large market. It used to be very lucrative for ULA, but SpaceX will lower prices so it won't be as lucrative for them.
Indeed, though the headline seems kind of odd to me given that it's specifically an Intel problem as far as I can tell, it'd be nice to have _some_ mention in there (even if people following this can guess anyway).
Great link, that video really does pack quite a lot of cultural context in a short time. If you're not from the US and understand each second of that video, you'll understand quite a lot about other things that happen in America.

I'm quite interested to see how Tesla's pickup truck does in this market. On one hand, it can be a total flop, because as you pointed out, huge swathes of this market exist because men need to acquire and exhibit their "masculinity" (as they understand the concept). Burning fuel and making noise seems to be one of the core components of this "masculinity". Coal Rollers simply take this to it's logical conclusion.

On the other hand, maybe its other attributes (0-60 times, towing capacity, size, technology, price) can be sufficiently better to overwhelm this "burning fuel and making noise" aspect and become a well-selling truck. Maybe buying a ridiculous 6-seater, $80k+ EV pickup will be how you update this "masculinity" while distancing yourself form the coal rolling assholes.
The person questioning morality did.

And that is OK. Let me be clear. It was thought provoking!
Seems to miss out John Mayall - https://en.wikipedia.org/wiki/Blues_from_Laurel_Canyon
Would it be possible to change the company's workflow to be less reliant on a single program's features?
Of course, fixing the application is always the best solution, but that’s not always possible. If you didn’t write the full application, then this isn’t something you can do. One of my standard use cases for this behavior is loading plugins into system apps and overriding certain behavior, which is generally not intended by the application author (although, in certain cases, this has been tacitly encouraged).
Generally speaking, "obvious" and very simple solutions of that sort to any kind of social problem tend to come with a raft load of unexpected and unintended consequences that can be difficult to prove and can be a net negative.

I'm keenly interested in better understanding the problem space. I am very leery of such "obvious" answers.
They don’t run native code.
At the Comic Con in San Jose earlier this year, the lines for Stan Lee's autograph were insane. Hours backed up at the dedicated empty table starting at 9am 'cause he'll be there at 2pm [or whatever].
What are the good-to-read academic blogs on any topic?
Most people don't even know how much they're paying in tourist taxes. I certainly don't. It's a hard-to-see line item on lodging, attractions, event space, etc.

What's the total cost? I don't know. Probably more than 1 percent and less than 5? How many more people would travel if costs were reduced by 5 percent? More than zero, less than a lot.

I was responding to a post arguing for MORE tourist taxes. I think we should we have less.

https://www.nytimes.com/2011/06/07/business/07taxes.html
Sent. Thanks we understand it’s extremely easy to blow off an idea that sounds like “legit ICO” especially when the SEC warns to look out for that language.

If you don’t find all the law to boring and get through it we would love feedback and/or questions.
No success yet. They are going to move the fairing catching boat "Mr Steven" from the west coast to the east coast to then try again. And the fairing is ~$6M so they can save ~$5M per launch if it works.
Nebula Genomics aims to speed research and lower cost of genome sequencing
Well the first order was at my old house. The next was last winter when we got the fall/winter influx. That repeated, even worse, this fall. The Victor Snap traps work great. But we need a bunch of them (and we'll probably need to find entry points and try to reduce that if we can.)
The issue stated in the parent is one of inconsistent quality.

The more apt comparison would be paying the costs for a seasoned CPA but with 50/50 probability of the numbers only being run by her assistant.
I suppose your 1000 free impressions ran out on thum.io
I'm not sure I agree at all.

99% of business in this situation, you would never call a startup.

New law firm.

New dental office.

Your uncle started doing roofing, asks your little brother to work his summer off from Uni with him on roofing.

A new golf course installed in a coastal area.

A 50 new homes going up in the suburbs.

The empty spot on the corner is now a little corner store - beer, wine, chips.

New taco restaurant down the street.

Nobody is calling these situations (i.e. the vast majority of new business) 'startups. So clearly there is a kind of de-facto popular lexicon - and it's not 'startup'.

And many new businesses are just called new businesses. Like the guy who started selling modified skis at the ski resort. That's usually referred to as 'small business'.

A group of people doing some kind of new thing who are maybe not seeking funding but could possibly seek VC funding ... this is more in the realm of what we call 'startup', wherein there is generally a larger market opportunity, and possibly higher growth ... this is startup.
The fragility of most companies and industries.
I'm continually amused that one of my favorite stories exists because of a volcano. If there ever was an episode of "Connections" that I could get in to, it'd be about this.
The web app is so fast I find it satisfying to experience it being rendered at seemingly light speed on any device.

It’s really a joy to use.
Synthesizing Structures in Rust with immense
The Linux team also needs to make a call on the kernel they maintain. You can always choose to stick with an older kernel or even patch out the fixes if you like.
Traffic laws being enforced?!? Now that’s just crazy talk :).

Ok, I admit shanghai is much better than Beijing in this regard, heck most tier twos in the south are (think HZ, GZ, and even almost 3rd tier Kunming). I’ve never been to Shenzhen before, but I can believe it is very different from Beijing :).
I just wanted to say thank you for your thoughts. They have certainly given me a chance to ponder.
Greenland ice sheet hides huge ‘impact crater’
AMD Looks to the 'Next Horizon' to Deliver Increased Datacenter Value
You are so wrong that it is hilarious.

Billy Joe buying heroin most likely has never owned any cryptocurrency. What part of your ass did you even pull this from?
To address the memristor existence questions: if you define a memristor as a device which "remembers" its resistance via a pinched hysteresis I-V curve, then we have had ReRAM/ memristor devices for some time now. On the other hand, if you define memristor as a device with coupling between charge and flux, then no.

Practically speaking, it's unlikely that memristors will replace transistors because they're about 500X too slow and have about a billion times less endurance. Same issue with memory replacement. They could in theory make excellent flash memory replacement, but currently sneak paths, thermal crosstalk and ion crosstalk remain challenges
> Who is avoiding travel because of costs? Almost everyone

This is patently untrue. NYC had just shy of 63million visitors in 2017, and is one of the most expensive places on Earth.

Edinburgh (where I live) has about 480,000 people, and we get about 2 million visitors in the month of August. Accommodation is full, and prices are 2 or 3 times what they normally are for the entire month, and yet the city is full. A tourist tax of 1.50 a night is not going to deter anyone from visiting Edinburgh when the bus from the airport is 5 times that, or a night in a hotel is 20 times that.
As you can see from the lack of biosimilars in the US, manufacturing a biological is a hell of a lot more complex and expensive than doing it for a small molecule.

And in fact, since this is version 1.0, I’ll bet a better version comes out before any generic company launches.
I have a few musician friends who lived in laurel canyon in that era and swear by that article. Sounds like it was truly a magical place and time
Are there any of those changes you can't disable for your computer? I thought all(?) of them were behind flags, since different hardware needs different sets.
If you watch Elon's interview on the Joe Rogan podcast, he actually discusses VTOL electric aircraft using regenerative descent braking. essentially the only added energy is air resistance plus charging inefficiency, his back-of-the-envelope math was somewhere in the 92% end-to-end range.
I would imagine that it was just one of these “next gen” products that identified the fact that Powershell was running on a machine that normally would not run Powershell.
Scan credit cards in your mobile app
It’s also worth pointing out that all ideal circuit devices are non physical.

But yes I think the name “memristor” is mostly PR.
A bigger difference is that Amazons brands are stealth brands. In every big shopping store, I know which brands are the store brands. Not so with amazon.
I've been burned by their dropping features and services too many times to ever gamble on them again.
Right, people hardly even consider tourist taxes and they’re often not visible when you’re rate shopping. So help me understand this claim from your original post:

>Tourist taxes are how you destroy diversity and trap people into the tiny bubble in which they were born
But you said it was serverless!
This sounds interesting.

What have you learned and what was difficult?

Capital?

Good sources for CBD or are you producing everything from scratch?
Interesting. I wonder if, in a “mind your own business,” curiosity-discouraged sort of environment, people might also be less likely to notice and report threats.

The first thing I do with credentials is find out what they open. Seems like if you have the resources to follow up on access attempts, you have the resources to set ACLs correctly so you’re not scared of them.
From Gene Editing to A.I., How Will Technology Transform Humanity?
This argument came up during discussions of Amazon HQ2. Whether its better to distribute. Or concentrate talent all in one location to foment a collision of ideas and egos.

I think about The Eagles and Hotel California a lot. It took them 2 years to record that album. Their previous rock-country records went platinum. But Hotel California sold like 10M+. That's what 10X improvement looks like. And it's obvious the effect of having Jackson Browne, Tom Petty, Lindsay Buckingham, et al right next door or down the street to bounce around riffs and lyrics.

PBS doc Soundbreaking also has some great Laurel Canyon apocrypha:

https://www.pbs.org/show/soundbreaking/
I remember the days when getting a new VPS instance meant placing an order and waiting for hours if not days for the server to be provisioned manually.

So when I hear the term VPS I don’t think cloud, I think ‘inflexibility’ and ‘manual setup’.
Hmm...so you are the other person who buys industrial quantities of mouse traps on Amazon..
FCPA seems naive to me. There no way to compete in certain industries in certain parts of the world without engaging in corruption and bribery. Maybe we dont want to compete, or maybe we are just supposed to outsource the grey stuff, but it definitely hurts US businesses.

What gives US prosecutors jurisdiction over a British company operating in Africa anyway? Simply that they have operations in the US?
When I want those kinds of perspectives, I usually check out the 'Isaac Arthur' channel [0].

[0] https://www.youtube.com/channel/UCZFipeZtQM5CKUjx6grh54g/vid...

Guessing as my uninformed self, I suspect we could recover energy by building a tower that acts as the opposite of a rail cannon. If the craft is emitting a magnetic field as it descends, it could create an electric current in the tower. Of course, it would need to nearly touch the tower or emit a very strong magnetic field, so the conditions probably contrive against this scenario.

<edit adds succeeding> Or, descend through a tower and let the escaping air drive a turbine.

I think the problem is that the energy has high intensity and low duration. It would be similar to asking if we can get some residential power with a military grenade.
It is pretty clear that it is not fiction, he even says that.
One of the fathers of Deep Learning is worried about its future
>If you want the traditional fanout, filtering, multiple queues that do different things on the same event/message, you use SNS and SQS together.

For this sort of use case, I've generally opted to go with a Kinesis stream, and I'm having a bit of a hard time understanding why a mix of SNS and SQS would be better here.
Oh, is that why every single paragraph links to a tweet? What a horrible way to write an awesome story.
How did you approach this problem and solve it?
Why do you assume that local businesses generating more revenue doesn't contribute to local incomes? It does, almost by definition.

In a housing supply restricted market, tourism can contribute to higher housing costs, but that can be fixed by removing constraints on housing supply, like zoning. And even when this effect is present, its effect on quality of life is counter-acted by the positive effect of tourism spending on local incomes.
Sounds as of 3.0 it became much simpler, as vuex doesn't sound as necessary.
"File Storage" is a bad idea for the same reasons comparing to FTP is. It might work for a near layman, but it can actually communicate misinformation to someone who knows slightly more about storage. Specifically, S3 is Object Storage, as opposed to File or Block Storage.

This is why "simple descriptions" are hard. Leaving nuance behind makes a lot of room for confusion.
Beginner CNC Programming – G-Code
Montreal looks to be only 3.5% extra, not exactly massive.

Their sales and goods/services taxes are high, which works out to close to 20% total tax on a room. Still not that crazy.

Source: https://www.tripadvisor.com/ShowTopic-g155032-i51-k6671607-H...
It's exactly the same thing in Lisbon.
Why not? Isn't that what they currently do for the falcon 9s? Sure, the rocket equation makes it more difficult since it's an exponential increase in fuel, but that's not impossible, right?
The hardest thing I ever worked on was a calendaring system for scheduling ads on/off. The UI was great, but I just told them "oh, send me a cron format string for scheduling". It was easy for them to do, but very hard to handle on the back end. Cron format strings aren't fun to reverse engineer. Why did I do that?

File under "things programmers assume about time". It kept doing "weird" things from the user perspective and I ended up writing more tests for that subsystem than anything else I've ever done.
What Happens to All the Asian-American Overachievers When Testing Ends?
When a Chrome (and soon to be also Safari, Firefox) connects to a web server over TLS it expects to see SCTs, Signed Certificate Timestamps from some qualified logs (in Chrome's case at least one of these logs must be operated by Google and at least one must not). In most people's setups they get these baked inside their certificates, but you can do it in other ways and that'll work too.

The SCTs can only be produced by these logs, and only when the log is shown the tbsCertificate data. The intent is that the log service promises to log all certificates for which it provides a timestamp. A Merkle Tree is used so that we can examine a log and obtain proof that it does indeed contain every certificate we've seen SCTs for.

So, your conspiracy needs to involve the Certificate Authority (Let's Encrypt in this case), the CT logging team at Google, and at least one third party log operator. Or it would be detected when it was tried.
two plus two equals four.

See that isn’t readable at all. I prefer syntax.

Edit: Ah u failed to actually press the button at the bottom!
I think the hardest problems I've encountered are the ones without a specific right answer but tend to be more something that finds a balance between many complex and often contradictory requirements.

These are typically problems that involve interaction with very complex meat-space concerns.
I'd assume a large part of drug consumers still buys from their dealer in person, and why would you use Bitcoin then?
Nanosecond granularity on all the ones I use, which includes ZFS, ext4, and tmpfs.
Code? I've been toying with a very specific type of proxy-based observable, and I'd like to compare notes.