skysight-inc/HackerNews huggingface dataset:
23andme is casual genetics, and misses a lot of the variants that are important clinically. These ancestry sites are the entry point, but not the definitive answer.

SNP chips are on the way out and whole genome/whole exome are becoming much cheaper. For many people (myself included) who are trying to diagnose a disease or understand our personal genetics at a base-pair resolution then VCF is the standard format.

Ancestry and 23andme use proprietary formats but all independent labs/clinics/commercial operations use VCF and it is the format that patients will have. If a patient is dropping a grand or three to get their personal genome, they are going to be receiving the raw data in VCF or BAM.

As a side note, your site asks if people "had their genome sequenced" but 23andMe results aren't a genome. It is a peek at a fraction of the genome. Your site doesn't accept whole genome data.

Also, if by "offices" you mean doctors offices or any kind of medical professional, then you are putting them at risk. Variant calls delivered to patients from a medical professional need oversight. Calls need to be made in a CLIA laboratory and pass through a genetic counselor. It is fine to skirt regulations if an individual is analyzing their own genome, but once you insert a third party, then you are bring in legal issues, reporting issues, and HIPAA issues.
I have helped many developers get the best remote job and startups find the best remote talent.

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This is absolutely insane.
Strictly taking everything people say at face value is great way to become somebody who "can't take a hint." The problem is that there are many things people want to communicate but would rather not say because they're likely to lead to uncomfortable situations.

Suppose a coworker offers you mints or gum every time you speak to them. If you only take their words literally, you'll think, "Gee, what a generous person," and miss entirely their true meaning: "Your breath stinks and it's bothering me but I don't want to hurt your feelings, so I'm giving you out where we can both pretend you fixed the problem before anyone noticed."
Ok, that is a little bit of a stretch for honesty... by that definition, every single shortcoming is actually about not being honest....
> I manage dozens of apps for thousands of users. The apps are all on one server, its load average around 0.1.

If you're at this scale you can do whatever you want. Most of the stuff I've made has been with simple building blocks like you've described, maybe thrown in with some caches and a load balancer.

Although I've worked with other teams who really did have the high scale request flows that require you think about using a different architecture. Even so, K8s is not the end game and you can make something work even just extending the LAMP stack.
One thing to consider - taking six loans like this is called stacking, and is expressly forbidden in merchant contracts and on the phone when dealing with any SMB lender. In most cases the person taking the loan lies to each lender that they don't have any other loans out. It's a huge cause of defaults, and it doesn't come from borrower innocence.
I think the article gives good reasons to believe they are not typos, why do you think otherwise?
Additionally, your money-starved business will probably have folded in the meantime.
Agreed. This feels a lot like the home lending crisis leading up to 2009. People taking out loans for far more than they could afford with interest only loans, ARMs, etc., or taking out large home equity loans for consumer purchases. What it speaks to is a huge lack of financial literacy.

I do feel for people in this situation, particularly those who are driven to the home equity loans due to unfortunate events, like cancer, in their personal lives. But I feel that it needs to be said that there's a not insignificant number of people who are caught in these situations precisely because they failed to plan and have contingency money set aside, instead spending to keep up with the Joneses.
An interesting control would have been to flip a single bit
but also flip a single char so that it flips several bits and compare the results.

edit: Reading the linked article, they describe one of their validation method:
> The Host header contains the domain the HTTP client resolved to connect to the bitsquat server. If the Host header matches the original domain, the corruption occurred on the red path (DNS path). If the Host header matches a bitsquat domain, the corruption occurred on the blue path
(content path).
This is absolutely not legal advice, but this author misunderatands what a confession of judgment is. A confession would be void if signed prior to debt being due, because you can only confess to debt that is defaulted on. See: https://oregoncivpro.com/orcp-73-judgments-by-confession/

“B(4) it must have been executed after the date or dates when the sums described in the statement were due.”

I am assuming most states share this rule, but I could be wrong.
Also, Cycling '74's Max is a commercial visual programming language that shares a lot of concepts and designs with PD (which you could think of as a free implementation of Max, but ideas have flowed both ways).

https://cycling74.com/

On the topic of procedural sound, you might enjoy this talk about Generative Systems with Will Wright and Brian Eno:

https://www.youtube.com/watch?v=UqzVSvqXJYg

At Maxis, we also developed a bespoke visual programming language for The Sims (first used in SimCopter), called "SimAntics".

We never officially released "Edith", the version of The Sims with the object editing and visual programming tools built in, but users have reversed engineered the byte code, and developed text based tools for programming custom objects with SimAntics.

http://simantics.wikidot.com/wiki:introduction-to-simantics

http://modthesims.info/wiki.php?title=SimAntics

Here's a transcript and video demonstrating it:

The Sims, Pie Menus, Edith Editing, and SimAntics Visual Programming Demo

This is a demonstration of the pie menus, architectural editing tools, and Edith visual programming tools that Don Hopkins developed for The Sims with Will Wright at Maxis and Electronic Arts.

Link to "Edith Sims Programming Tool" section:

https://medium.com/@donhopkins/the-sims-pie-menus-49ca02a74d...
Human productivity is at its highest point in human history, so one can't help but wonder why we must all work harder than our ancestors to exist.
I've read a bit of Christopher Alexander, and at least by his view the profession of architecture was in a fallen state conducive to soulless work. I don't know myself, except I've been to Barcelona which must've been doing something different.
https://news.ycombinator.com/item?id=18437066
>Can we just say "Darwins law" and let it be?

Only if we are willing to say the same once someone decides to fight back with actual force. If someone outright kills a scammer doing this, are you willing to write it off as "Darwin's law" and let it be?
Differences in Temporal Synchrony Between Brain Regions in Autism and Controls
That is cute.
Is there a "human readable" bar code variation? I want something that's both scannable and typeable.

One use case is those placards for artworks at museums and galleries. I want to print something that's both easy to scan and easy to jot down.
Welp, I clicked on the link. Did not log into instagram. And saw following:

==========

1,976 posts
22k followers
1,117 following

juan_ZILLAA

Something like a " Wall Street wolf "

2014 Alpha 12x GTR

2015 Range Rover sport

2016 Lamborghini Huracan

2018 Ferrari 488 spider

==========

Looks like he's made a few millions and fancying himself as a Wall Street player.
I agree - I think there's a very important to differentiate between cryptocurrencies and digital assets
I always get excited when I read these things that I might be lucky enough to see a supernova in the sky in my lifetime (provided the gamma ray burst misses us!).
Some use cases for digital p2p cash :

* Porn

* Donations to wikileaks

* Pot

* Sending money to Venezuela

* Leaving Venezuela with your wealth intact

* Payments without giving all transaction info third parties (PayPal, VISA, etc). Look into Monero for untraceable transactions.

* Digital payments for the unbanked

These are all served better by cryptocurrencies than other alternatives.
Spectrum: client-side image transcoding library
yes. good catch. They've only ADDED a few dozen cars in that time.
It was kind of chilling to see the author’s depiction of “throw-away workers” twenty years ago in a modern context. The aside of “maybe he’s about due for his pension” might have seemed so heartless then, and yet today, someone in the same position as that 50-year-old has, at best, a fickle 401(k), and at worst, simply nothing, as a participant in the gig economy.

Maybe that 50-year-old is trying to make ends meet delivering for Caviar, and a short series of slip-ups and consequent low ratings causes his “position” to be automatically terminated by an algorithm. Throw-away workers indeed.
How to Choose a Niche for Affiliate Marketing and What to Promote
Are the rules for what it does allow written down somewhere? I know country flags work: 🇩🇪
I think that kub and, generally, cloud providers have allowed for more ambitious projects to be generally accessible.

My side project is intended to handle > 1 billion events per day, with fairly low latency. That's well over 10k events per second.

I doubt I could do this easily on a single box, and I wouldn't really want to try. Why constrain myself that way? Is it worth just doing this the standard LAMP way?

More and more problems are available to be solved using commodity systems, so we have more and more people solving those problems with these new systems.
> we know now QM is non-local, and that the underlying justification for the Copenhagen model is an extraneous philosophical proposition.

What underlying justification are you talking about and what do you understand by "the Copenhagen model" precisely? At least in the Einstein vs Bohr debates the one denying that QM could be a complete theory because of its non-locality was Einstein, I think.
How Parents Teach Smart Spending with Apps, Not Cash
> Hippie? That novel has often been characterized as semi-fascist,

Well, the “Hippie” characterization was made by GP of the rest of Heinlein’s work (which GP does not like), not ST (of which GP approves).

It's not an uncommon reaction to some of RAH’s work, Stranger in a Strange Land particularly, but it's just as wrong as calling ST semi-fascist.
They were up to date on their payments. There was no hint they were ever going to default. It's pure supposition - of the blame the victim kind - to imply they were running some kind of inverse scam, even subconsciously, or that they would have stiffed the lender.
The suggestion to invalidate cache is also in ACPI 6.2A 16.1.1.2 Example 2: S1 Sleeping State Implementation (page 783)

http://www.uefi.org/sites/default/files/resources/ACPI%206_2...
Django core no more
At least with conventional scams it’s up to the victim to voluntarily hand over the money to the scammer. In this case it’s different because the government is complicit in the scam and forcefully takes the money from the victim to give to the scammer.
Somewhat off topic, but does anyone know the name of the crazy circular moving barcode thing that Apple uses to pair an Apple Watch with an iPhone?
From what I understand, inability get laid is not the issue. The problem is that these guys believe/know they are top quality in everything except appearance. Therefore they deserve top quality women, which to them means physically attractive. As these women are not falling over themselves to get with the incel, there must be something wrong with society. So, they rage at society for brainwashing their women to fuck the Chads (their word for men that successfully date the attractive women - which they call Stacy).

To me, the whole thing just looks like narcissism.
I've only heard of them scrapping carbon cap + trade and fighting against carbon tax. If they've also dismantled regulations regarding more acute, pressing types of pollution I'd like to know.
A Perfect Target for Cybercriminals
I did a little digging and found that's it's the (((usual suspects)))
UK: Info Commissioner Appoints Expert to Research Impact of AI on Data Privacy
We could go back farther with Sutherland's SketchPad (early 60s) and Smith's Pygmalion (mid 70s).

There are also a lot of disparate visual programming paradigms that are all classed under "visual", I guess in the same way that both Haskell and Java are "textual". It makes for a weird debate when one party in a conversation is thinking about patch/wire dataflow languages as the primary VPLs (e.g. QuartzComposer) and the other one is thinking about procedural block languages (e.g. Scratch) as the primary VPLs.
I remember the first programming languages I used (when I was very young) were visual. I think Flowol at primary (elementary) school was the first. They gave me a pretty much instant understanding of how imperative programming worked. Admittedly, I never created anything practically useful in it, but what's important is that I could imagine, from early in my life, what programming could do / was for, and put it on my cognitive radar.

As a child I was more inspired by seeing the inner workings of something than being told X was possible if you learn to code. Visual languages can better expose the guts of the working automaton.

That said, I agree that [current] visual programming languages have shortcomings that limit them to simple / educational scenarios.
Sure, 1970s
Hm, interesting. I noticed HN started responding to HEAD requests with 405s recently; perhaps that is the cause.
Geometric constraint solvers are essentially graphical, declarative domain-specific languages for mechanical/physical design. As an example: http://solvespace.com/index.pl
Store, share, search encrypted files in Google Drive and Dropbox from one place
The human costs of Black Friday, explained by a former Amazon warehouse manager
Disclaimer: This is my own personal advice. It is different from what has been commented so far, but hope it might offer a different perspective or angle.

Don't believe your labels, even one's you give yourself. Why do you think you are introverted? Is it because you took some Carl Jungean-esque test like the Myers Briggs and it said you were? Is it because your parents and teachers always said you were "shy"? Is it because you have anxiety disorder or depression? You mentioned this last one might be it but aren't sure -- if you have a hunch, go talk to minimally a therapist to find out.

Toss all that shit out the window. You aren't your labels. You are exactly who you want to be.

If you don't want to be introverted anymore, don't be. As some one who was the "shy" kid and introverted from basically age 4 to 19, mainly staying inside and playing video games, it would probably shock most people to tell them that I consistently score "INTP" -- who cares. Take a pragmatic approach to it. If even the thought of being conversive, over communicating, and going to events exhausts you, that's not introversion that's probably some disorder -- you mentioned social anxiety, for me it was depression -- we are human and we were meant to communicate, be social, and relate to others. I am not saying that to say "so you are wrong" I am saying that so you understand. If there's something deep down there that is the root of that, address it. For me, going to therapy helped. For others -- the root of the social anxiety is a troubled pass: an abusive relationship, a missing father or mother, or a relationship that desperately needs mending. We put up our walls and think these things aren't affecting us, but they do. A lot of people think therapy is for people who have things "wrong" with them. I think therapy could help every single person on this earth, no shame in it at all.

The last advice -- treat it like a challenge. Have fun with it. Hack at it. Try different things. Read. A lot. Listen to your body. Best of luck on your quest!
I think there's more depth to the film than you might be giving it credit for. There's a lot of goofy heavy-handedness on the surface, but there are some layers underneath, in the writing and the arcs of the characters

The guys at Red Letter Media did a pretty good breakdown of it[0] all in all. But even just consider the scene in the beginning when Rasczak is teaching the class about citizenship[1]. It's goofy and funny on the meta-level, because, well, it's Michael Ironside, and he's saying things that at first pass sound insane. But there's a whole lot in that dialog, and it's all played deadly straight. And then compare Rico's genuine, "I don't know" there, to where his character is at the end of the film. I think it recommends itself to a lot of different levels of examination, without sounding like you're trying too hard.

---

[0] https://www.youtube.com/watch?v=OkEdyq3UE5M

[1] https://www.youtube.com/watch?v=EBxgrr0wL8M
I feel like being interested in space is an exercise in being simultaneously enthralled and disappointed. This sounds awesome! But, like with basically everything space-related, the scale is too immense for a human lifetime:

> Of course, it's important to bear in mind that "just about to explode" means something different in cosmic terms versus human terms. It could happen at any time in the... next few hundred thousand years.
For the people reading this who might be on the fence about k8s and its "solidness", keep in mind that hostility like what's being shown here is exactly the kind of thing that holds good tech back. Don't fall for this evidence-less claim, look at what people are accomplishing and the issues they're running into.

Find the positivity about the tech, and see what those people have trouble with. Tons of case studies to demonstrate, resoundingly, that k8s is "solid": https://kubernetes.io/case-studies/ . See what these people struggled with, and that'll give you a better idea of who's right here.
who is Gerardus Blokdyk ?
meanwhile in the UK we have actual chickenpox parties to try and spread the infection to as many children as possible while they are still young enough that it doesn’t cause the complications it does when you reach adulthood...

https://www.nhs.uk/common-health-questions/childrens-health/...
Disabled for specific languages. That means either: the page was misclassified as a different language, or there's a bug affecting those preferences, or it was a user mistake and the translation was turned on.
Right, but that's thanks to innovation in the digital media space and subscription models, not necessarily regulatory pressure.
>And if you submit a proposal that says "I'm going to go off and work on this crazy idea, and maybe there's a one in a thousand chance that I'll discover some of the secrets of the universe, and a 99.9% chance that I'll come up with bubkes," you get turned down.

>But if a thousand really smart people did this, maybe we'd actually have a chance of making some progress.

The problem is, as I understand it: suppose some people locked themselves in their attic and worked on physics problems; how does society know that they're actually working on physics and not merely twiddling their thumbs?

The whole publication-review-credit-tenure-grant circuit was invented to address exactly that situation. In order to replace it, you need some other way of convincing the funding bodies that their money is actually paying for something.
Not really, because there are thousand others that can out offer you.
I maintain a tool that reports errors on Linux systems with ECC memory, and also a website describing the tool (http://mcelog.org). I wrote about patterns in the access logs correlated to time some time ago in my blog:

http://halobates.de/blog/p/181
As other people stated: they build standing from the shoulder of the giants.

And even if they had started from zero, these guys are the exception, not the norm.

We can find 20 year-old geniuses in every camp.
While i like the sibling comment's network errors answer better then mine I didn't see any reasoning other then a unfounded statement[1] in the article or on a quick skim for "typo" in the referenced whitepaper:

[1] "These requests were not typos or other manually entered URLs"
People are quick to point out "nobody uses QR" but it's not exactly fair

I think everyone uses them, but they just don't know it.

Pretty much every label on every consumer good (in America, at least) from cough syrup to Coca-Cola to computer chips has a tiny QR code on it. But since people don't actively engage with the code, they don't realize that it's there, and is a big part of the process of getting things from raw material to store shelves.
Sure, but there are some interesting and affordable tabletop experiments being done to probe certain features of QM (like Weak Measurement: https://www.hep.ucl.ac.uk/qupot/) and test fundamental assumptions. The work on that front is progressing, but when people think of "Laws of Nature" i.e. GR and the Standard Model, short of expensive facilities like new particle colliders or telescope arrays like LSST and Cosmological surveys, it's unlikely "new physics" is going to be jumping out of the woodwork any time soon.

Which is not to say people aren't trying. Conferences are held probing this exact question (e.g. can we come up with DM detectors that aren't just enormous tanks of cooled liquids?) and trying new strategies. It's not like the community isn't engaging in good faith with some of these proposals, it's also that we haven't had a new hint of where to look from a collider experiment since the discovery of the Higgs. Despite everyone's best efforts. Yes, we need some experimental ingenuity to push through this frontier, but I also agree with OP that Physics is just being very stubborn against yielding any further secrets at present.
I still don't get why you call it a toy, or just for prototypes. Maybe think somewhat broader and not just about the bad experience(s) you had with it. For the things it's good at, it just works and it's pretty hard to find alternatives (well, Measurement Studio is ok, but for simple things it's usually still a bit more work than Labview). The hard part is figuring out what Labview is good at and not make the mistake of trying to use it for everything. Sound like that's where most of your bad experiences come from.

Here's an example of a place where Labview just shines: I needed something to plot 'rolling' analog and digital signals, i.e. basically provide a visualization of the inputs of a combined analog/digital input card. With ability to pause the thing, each line in a different color, data cursors, ...
The data is acquired by C++ code, but since Labview has this stuff built in getting the whole thing up and running is just a matter of setting up a communication protocol between the C++ part and Labview. I just went for TCP/IP and got the thing up and running in a couple of hours. Has been used like that for years now. Not exactly a prototype, nor a toy. It just does this one thing, it's all we needed, and it does it extremely good.
Decentralizing Social Interactions with ActivityPub
It was interesting to note about workers and using web assembly together within V8 as this scenario could bypass the need for complexity and memory overhead, while combining different programming languages on the server-side. Not that it could replace Kubernetes as that is an amazing technology but if you are in a scenario where your tech could fit within workers, could be interesting. https://blog.cloudflare.com/introducing-cloudflare-workers/. I was amazed to think web assembly would be used for that purpose but i guess it does make sense in reading about how it is put together.
How to become drastically faster at using the terminal
Cryptocurrencies can be centrally controlled.
Or Ultima!
Statement from President Donald J. Trump on Standing with Saudi Arabia
PyCoder’s Weekly Issue #343