skysight-inc/HackerNews huggingface dataset:
People are fixated on the price for this drug, but the article itself is pretty clear on the rationale for the price tag: current alternative therapies have a price tag of up to $300k/yr, indefinitely. This drug is a one-time therapy. Presumably, any health system would jump at the chance to replace a $300k/yr recurring charge with a 1-time $1MM fee.

But they don't. Health systems in Europe apparently refuse to pay for this therapy. The reason for that, from reading other articles, appears to be that it is of questionable efficacy. Patients report fewer pancreatitis attacks, but clinical indicators like blood fat levels are apparently unchanged. The tiny market and efficacy concerns might explain why the therapy is no longer available at any price.
Now I see your point.

Not buried yet, it was still front page. Only after I replied, did I notice you posted 2 days ago... peeps getting ready to break loose for the Thanksgiving Break Slowdown? IDK.
Dramatization has nothing to do with credibility. It is a memory facilitation technique. Because you the reader can remove the drama and distill the critical story elements for further inspection of credibility.

Credibility is found in the citations, which here is only the story teller. As that is only one data point, I totally understand doubting its credibility because one needs more citations and voices for proof.

Further, I never stated I found the story creditable. I was operating from a believability standpoint. Inferring one's experience to weight if the story could possibly be believed. You shared you found it hard to believe based on it's dramatization. Where I shared that I found it completely plausible based on my experience.

And that is my main argument, that in this equation drama shouldn't be used as a weight. Positive or negative.

Edit: For the folks down voting this. Please don't conflate dramatization with persuaion, propaganda, or fake news. Dramatization is a tool used in those techniques.
Oh that's a good point. It doesn't always. I'd say 2/3 times, 1/3 times something else happens. Usually I manually hibernate first.

Also connecting two HDMI monitors is wonky, monitor 2 flickers once every other minute or so (it's worth it) and sometimes isn't detected.
KAT VON D FALL LOOK
I mean... shortened obscure names for things in the tech world isn't exactly unique. Here's one for basic UNIX commands:

ls list_files Lists files in a directory
cd change_dir Changes the current working directory
cat cat_barf Takes stuff in and immediately hacks it up onto stdout

Etc.
no one will use it if it [...] is unnecessarily
difficult to work with

In some aspects of security, you can trade off inconvenience for cost, instead of trading off against security.

For example, imagine an office with a security gate, but it takes a few days for new employees to be issued with a working gate pass.

One way to reduce that inconvenience would be to trade off security, by having staff members buzz strangers in if they know the magic words "I just started, my pass hasn't arrived yet".

An alternative way would be to trade off cost, by having while-you-wait gate pass printing, and every gate having a guard who can check an online employee directory before buzzing someone in without a pass.

I feel a lot of people say "Security is a trade-off with convenience" when they actually mean "Security is a trade-off with convenience and spending, but we've already taken spending off the table"
No, counting on the hands is not base anything, because positional number systems did not exist. Just like Roman numerals or tally marks aren't base anything.

People counted on fingers like with tally marks - they could express the numbers one through ten. Thus ten became an important and familiar number to humans. Thus it would have seemed natural to use a base 10 number system many millennia later.
pretty sure Rust should have been Typescript in that sentence, otherwise it makes no sense.
We're seeing a lot of interest for two reasons:

* WebAssembly

* "I've always wanted to try something lower-level"

That said, this reads like a typo to me, I think it should be TypeScript.
https://www.psychologytoday.com/us/blog/animal-emotions/2016...

People (and ravens) cannot help but act differently when they're being watched. Being watched (by anonymous viewers) is a stressful vigilance state.
I could've run "net accounts" on my workstation to query Active Directory directly & see their password policy, but decided to look elsewhere first. I didn't want to set off any alerts or logging.

I know nothing about Windows, but I'd have thought checking password policies far less likely to alert than plugging in your own device on the network.

Anyway, my favourite bit was that they didn't stop the people in Accounts running Powershell, they just raised an alert. I much prefer that approach to blocking people most likely just doing their job.
It looks like the UBlock-LLC still has a GPLv3 license file. Are they violating the license in some way?
Makes it more likely for him to agree :)
Maybe it’s more of a security feature? What if phishing emails had a bogus email for the Reply-To name, E.g., “service@paypal.com <hacker@evil.com>”
More than just the feedback loop between code and response. The feedback loop between what you have to do, and what you want to happen.

Rather, I'd reword it. Just getting faster feedback from coding to some response is not enough. It has to be to the desired responses. (So, for example, it doesn't help to get faster feedback to syntax highlighting.)
"Spain does not have a competitive economy and that's that."

Competitive how? Salaries are lower than in Canada.

Competitive with who? Do you mean the productivity is low? That's a function of industry development, that is impossible without investment.
Thanks! Both for the clarification and noting the mistake. Here's the original article:
(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431903/
How will you guarantee that the data manually entered in your system is true or false? I had the same idea though, so many bad recruiters out there it's hard to find the good ones.
Thank you so much! This is great advice and I'm excited to look into the links you posted. Appreciate you taking the time :-).
But objectively, U.S. internet access is faster than German internet access (or U.K., France, Spain, or Italy, which comprises like 70% of the EU population). According to Akamai, 50% of U.S. connections are over 15 mbps, versus 33% of German, and 18% in France. In states that are as dense as Germany, like Maryland or New Jersey, it's 60-65%. According to the OECD, fiber deployment in the U.S. is 12.6% in 2017 versus just 2.3% in Germany. The U.S. is also better positioned than those countries going forward. More of our infrastructure is hybrid fiber-coax, which can be incrementally upgraded by pushing fiber deeper into the network, and is on the path to symmetric gigabit in the next few years. Countries like France are much more reliant on DSL, which is really hitting its limits. (But the DSL can be "good enough" and cheap.)

Which is really remarkable when you think about it. There is no other infrastructure that the U.S. does better than Germany or France. Our trains, subways, and roads are shameful compared to theirs. But our internet access is better. That's a real testament to the success of the 1996 deregulation.
I guess my problem is they’re not ultimately some new product. Based on previous outages for this same product they’re basically reselling Ceph. There’s no new technology here.
The Chance of a Lifetime
Thanks for a more thoughtful reply. It's personal experience, not random and certainly not pseudoscience. I purposely made it short to see if anyone would be curious. A yoga practice from a qualified teacher is a powerful thing.

Try going to this page and doing a search for sleep:
https://www.yogajournal.com/yoga-101/krishnamacharya-s-legac...
I just don't care about them. They don't harm anything, I just never really need a link to go back to the top of the page, so I barely notice their existence.
The solution to someone stealing your brand is to just let them have it? Do you work for UBlock-LLC?
Programmer is the factory job of our time.
Jeff Hawkins dismisses the metaphysical in his theories. Is this true of the neuroscience world in general?
No, but one can get code to perform as fast or faster than C with any other systems programming language, especially if they have templates/generics.
tbh I'm surprised it took this long, PHP has been unfashionable for a very long time now. I suspect some of it might be because Django has become "the new wordpress" in many ways, and some because a lot of PHP users are one-man-bands who could already do JS and so find it natural to move onto Node.
Google to Sunset Analytic Services SDK, Transitions Mobile Analytics to Firebase
I suspect that the person who made this site worked at Amazon. The way they describe SWF makes me think that the author used it when it was in it's prerelease, "Decider" form. The "Flow" version that went onto become the one that was publicly released has a slightly different set of terminology and doesn't expose the use of queues in the same way the Decider version did. I love publicly released version of SWF and think it's a severely underrated product.
Which agreement?
If they can keep it free, I’m all for it. But currently I think too many providers are gouging, hoping to be the next Netflix (I’m looking at you, CBS).
I do something similar where I keep reading until I literally can't keep my eyes open and my e-reader falls over. Usually I find the next day that I don't even remember the last couple of pages I read.
You can downgrade to the free card or just cancel it.
What precisely is shitty and broken about gmail's IMAP implementation?

Gmail's IMAP implementation implements three RFCs I wrote; I haven't noticed anything wrong in those areas. Are my RFCs unusual or am I overlooking something?
Consider gorhill may not have the resources or interest in doing all this work. uBlock Origin is a fantastic free product but it's a little chaotic. I wish it could be different.
I've thought about this as well, but in a different sense. Think if cloudfare were actually the NSA. Seeing as how ssl terminates at their edge server before they pass it off to your actual server (whether they re-encrypt it or not), they have access to all of the decrypted traffic in transit before it reaches your server, don't they?

> When you use Cloudflare, we must decrypt the data at our edge in order to cache and filter any bad traffic. Depending on the SSL setting from the options above, we may re-encrypt or send it as plain text. (full vs. flex) Since each certificate needs a dedicated IP address, we add your domain name and wildcard (*.domain.com) domain in the SAN (Subject Alternative Name) to the certificate.[1]

[1] https://support.cloudflare.com/hc/en-us/articles/204144518-S...
Interesting post. Hopefully some innovators can come through and figure out a way to make it more cheaply. Even if it's expensive now, if humans exists for 100's of years, then eventually the price will come down when this inventor is toast, right? Either that or people will figure out cheaper, DIY ways to do some of this biological manipulation.
Not a wasteland, just sparsely populated like Isaac Asimov's Solaria. Don't worry, the countryside will be just fine without people. Just read The World Without Us.

I guess I'll become an agricultural robot repairman like the guy in Interstellar when I grow older.
CMake is “common make” not “C make”, it can make anything, and package it with CPack, test with CTest and so on. It’s still being developed too.
I don’t use emails much on my MBP (2016), but I had to send one today. I loaded up gmail, waited a bit for it to load, then clicked ‘compose’ only for the interface to show ‘something is wrong’ in various places.

In the end I just setup email in the Mac email client.

This was in the latest Firefox, and I know chrome is supposed to perform better for gmail, but writing an email on a 3 year old laptop shouldn’t be a big issue, but here we are.
NICE, which makes value for money decisions for the NHS, uses a threshold of £25k per Quality Adjusted Life Year for assessing cost effectiveness of treatments.

At that threshold, to pay for an £800k drug treatment you'd need to give someone 32 extra years of life (or 64 years at double the quality of life and so on). This is enough to pay that kind of amount for life saving gene therapies, especially if given to young children but not enough to treat something that can be largely managed through diet control.

Since the majority of the world's patients are in Quebec, I don't understand why the provincial government doesn't cut a deal for this drug. I'm sure they'd rather sell it $250k a dose to a nice big patient population than at $1m to nobody. Quebec has a lot of pricing power here as the only large potential buyer.
True. Information security criticality migrated to applications a decade ago and never looked back. Internal networks are almost always easy to compromise. We have never failed on a 1000+ entity network. This implies, rather strongly, that you need to silo critical data and protect it at the application later, because the network is very hard for most organizations to secure.
An alternative is that Google has a main revenue source, but they would like to diversify that.
Tuples have fixed size and are typically short and are not really collection types. They are a compound scalar that is meant to associate meaning with each position. Tuples can contain different types because of this, while collections are typically homogenous. Tuples do not also really have the concept of “empty” indices, in the way that fixed-size arrays do.
We have loans for education even though lenders can't repossess knowledge.
The future is an abstraction. I'd say your definition is a superset of OPs.
These terrorists are upset about the same thing you are, the ties that essentially make Saudi Arabia a vassal state. Cracking down on them only strengthens those ties, fostering more anger.
This story is also available as a series of tweets in case anyone prefers to consume it that way.

https://twitter.com/TinkerSec/status/1063423110513418240
Not the GP poster, but the most frustrating thing for me is that GMail labels are implemented as IMAP mailboxes instead of IMAP flags.
cat concatenate Concatenate all files given as arguments as well as stdin.

Similar to: Your twitter feed
The first choice strategy obviously would be to automate this stuff.

Because it's hard to mandate a flag day where everything must be automated, a transitional strategy might be: document each dev setup so well stepwise that you can outsource it to the IT dept or other internal support org. Maybe the dev team can provide a screencast of it, for example. The support org would then have an incentive to automate it to replace manual work, along with a measurable payoff for it.
I usually use the home and end keys on my keyboard.
I am not defending Intel, but firmware encryption is a very common thing in embedded software. The new ARM Cortex M33 architecture adds a ton of security & encryption features. This is becoming increasingly important in IOT devices.
Managing risk in machine learning
I suspect the appeal of an ad model is that it's perpetual recurring revenue.

It's the same direction they go when they desperately push subscription licenses (see: Office 365) They want a business model less dependent on people replacing their PCs every three years.

I don't doubt they see a rapidly approaching future of management saying "these computers are more than adequate for office work and web browsing, so we won't replace them until they physically fail in 5+ years." It's an easier and easier argument to make, especially when we're running out of easy, cheap across-the-board performance boosts. (Office and Chrome don't run that much better on a new 32-core Threadripper than on a second-generation i5)
Is there truth to that last one? I always assumed cat was short for concatenate and my brief googling appears to confirm that. Would love to read more on this if someone has a reference to cat_barf
Or we could tie them to the size of our leader's hands, which is very very small, even though he tends to brag publicly about how big they are and what that means, and repeatedly sends photos of them to magazine editors.
Yes, good point - I was thinking about casual, everyday uses, but if you're going to be precise then the question of divisibility becames even less relevant. Just tack on as many decimal places as you need.

It's true that this applies just as much to non-metric units, of course! But then if divisibility isn't a big deal, this goes both ways - meaning that the disadvantages of the metric system's base 10 orientation may well be minor in practice, and not enough to outweigh the advantages.

(Actually though I think the metric system has you more cleanly covered for this sort of case, with its consistent set of prefixes for scaling up and down by 1,000. Non-metric units tend to be a random jumble of 8s, 12s, 16s, or worse.)
I don't think he understands pricing at all. Market price isn't arrived at via a rational process. It's an inherently social process arrived at by negotiation between producers and consumers.

And it's especially weird that he thinks pricing shouldn't be political when his product has a government-granted monopoly and the bulk of its customers will be government-run health-care systems and government-licensed insurers.

Sure, there's a real question of how to pay for treatments for rare diseases. But the millions in development are a sunk cost. To take his ball and bat and stomp off would be disappointing in any circumstances. But when people will die because of it?
Any good MOOC for this? I have a "poor man's DGX" at home (2x2080Ti with NVLink & 2xTesla K80 in peer mode, 24c CPU, 128GB ECC) and would love to have a unified access to all of this.
Calculus made easy
If investors don’t like the dual stock structure, they don’t have to invest. What am I missing? Why should congress step in to ban something that by virtue of these existing investors, some people are fine with?
Interesting... so it looks like RTX can cause cell death. Perhaps this shouldn't be surprising. Glad you updated that link.
Microsoft's behavior here and Canonical's behavior shipping search tied into Amazon tracking show that this is not a pretty rational stance.
Where are you people trying out KDE?

I'm on KDE Neon now, after having used Mint for a while. KDE is simply a joy to use. Everything works, and the visuals are consistent and well-proportioned.
Check https://sia.tech/ for actual product.
Netflix and other streaming services seem to do a good job of resurfacing TV shows and movies from the past. Much more effectively than syndication or cable channels did since they're all available all the time.
7 Dangers of Going Keto
https://amturing.acm.org/alphabetical.cfm links to a page for each awardee, with a link to their lecture.
I don't know if I agree. While obscurity can be a deterrent, I imagine most groups are unlikely to come up with sufficient, convoluted complexity to prevent identification of exploits. Primarily because you're effectively pitting yourself against a collective of $hat hackers, instead of doing things "right" and attempting to use encryption.

This doesn't mean it isn't a deterrent, but doing things in an obfuscated and unusual way also means you're potentially treading on unexplored ground, and so there will potentially be other exploits, bugs, innefficiencies which can come with the territory.
Note: UBlock-LLC is owned by Betafish, the company behind AdBlock.
Cat is for catenate. Later the word became concatenate.
https://arstechnica.com/information-technology/2018/11/major...

a lot of users had issues.
Maybe add TS into the mix, but I doubt it's a typo. TS is just a subset of JS.

I'm a JS developer and learning Rust is one of my side projects. I've built a few hobby projects that combine both. They work well together and Rust is a much friendlier language to work with than C/C++ (IMHO).
It's not even clear that this therapy is locked up because of IPR. If you read uniQure's filings, their patents appear to be for treatments for other conditions (notably Huntingtons), and their protection for the LPLD therapy is under "orphan drug" protection.
Threader – Compile Your Twitter Threads
You can load gmail is basic html mode, it might help.

According to https://support.google.com/mail/answer/15049?hl=en, the following link should set it to basic html mode (I haven't tested it)
https://mail.google.com/mail/u/0/h/1pq68r75kzvdr/?v%3Dlui

I've used the basic html mode before when the normal (js heavy) one was a bit slow, and it ended up being much faster even if every action requires a whole new page request/render.
Https://unix50.org: celebrating 50 years of Unix
To me, Gmail Classic is this original look:
https://techcrunch.com/wp-content/uploads/2010/08/priority1....

I loved the "Original Classic". Every update since has worsened the look & feel.

When Steve Jobs passed away, the whole software industry took a gigantic step backwards in design. There are lots of great designers in the world (have a look at https://dribbble.com/ ) but the people who hire designers often can't tell a great designer from a mediocre one, and that's how we end up with the not-so-great design of the current generation of software, including those from Google and even Apple.
You should really try out KDE Neon, it is by far the best and most consistent DE available for Linux, and is so far ahead of Win10 it's sort of embarrassing for MS.

The default settings are very sensible, I only change one or two things myself, most noticably focus follows mouse, which requires a silly gconf tweak and is considered "broken" by the devs.
Universal human language
What's with forks of adblockers just lightly modifying the name?

uBlock -> uBlock Origin https://en.wikipedia.org/wiki/UBlock_Origin#History

Adblock -> Adblock Plus https://en.wikipedia.org/wiki/Adblock_Plus#History_and_stati...

Is the temptation of skimming off existing branding worth the mass confusion?
Flagged as low content blog spam
This ad was specifically targeted towards rural communities which have poor public transit networks and where driving is a given. This doesn't represent the attitude of many Americans. Americans are pro transit in the cities. Not as much as Europe, but certainly not as bad as you make it out to be.
Makes me proud to be American... shit it even made me forget I am actually from poor Poland
Dupe: https://news.ycombinator.com/item?id=18459359
Best book I know to understand how the world really works. Here is a link to an abridged version: http://sqapo.com/machiavelli.htm
The author confirmed on Twitter that "aside from the beating up and tying down" this is a true story[0].

[0]https://twitter.com/TinkerSec/status/1063781216128835584
I think you are quibbling about things that 99.9% of people quite frankly don't care about. A substantial group will leave everything default and for most of the rest the fact that you can change the colorscheme/style/background is sufficient.

It's somewhat like a wine aficionado discussing the 7 delicate flavors that or an audiophile considering the virtue of using a slightly more expensive cable.

So when I ask how it makes a difference I wasn't looking for a trivial redefinition of the word I was asking rather what difference it makes. Do you believe more people will use it if its pretty? Do you believe more people will enjoy using it if its pretty? To what degree and why?
This sounds huge. I'm hoping it is a trend that is either already common and I didn't realize it, or that catches on in the industry.

The rapid iteration of many parts of our industry is fun, at times. There is something for stability of foundation, though.

Edit: Copied this into the original posting...
> TS is just a subset of JS.

Semantic typo: you meant superset of subset of JS.

(pedantically that predicate would apply to all other languages in the universe)