skysight-inc/HackerNews huggingface dataset:
The thing is - everybody already knows this. Jeff Bezos has been open about this being the plan since the IPO in 1997, and that's why investors continued to give him money despite Amazon barely turning a profit for 15 years. Most customers knew this too - folks I know are like "Yeah, I know that once he gets a monopoly he's just going to raise prices and we'll be the ones hurting, but in the meantime I'm going to enjoy my low prices, free delivery, and convenient one-click ordering."

Tragedy of the commons is a remarkably powerful business model. Everyone knows that collectively they're going to be fucked over by Bezos in a generation or so, but since everybody knows it, they're powerless to avoid it, because individually each person is just screwing themselves over by not buying from Amazon.
Spying Doesn’t Pay – Unless You’re Really Good at It
This is an excellent response and you clearly understand the issue well. I'm curious though, what do you think about the long term effects of continuing to practice gene therapy? Sure, the cost for treating the first few patients will be exorbitant but wouldn't we expect researchers to find ways to bring costs down over time? How will we know if this is even possible if we abandon gene therapy at such an early stage? It might not make market sense to produce these therapies right now but I think there is a strong argument for governments to fund this type of research.
Thank you for raising this.

I think the reason this particular drug didn't make economic sense was touched on in the article but not highlighted: the drug approval process is designed for drugs, not new technology.

The price of a new gene therapy technology applied to a small pool of people can't justify it's cost of bring to market.

There are plenty of cases where drug company's inflating their margins using phantasmal threats of "R&D" costs on a condition that effects millions, but in this case it seems like the economics were unfortunately not feasible.
Ask HN: What board games will make good office holiday gifts for my team?
I'd like to buy members of my team each a different board or card game for the holidays and am looking for suggestions. Ideally, it would be something we could play together at the office every once in a while.

Some parameters:

- Less than $30

- 3-6 players

- Playing time: less than 30 minutes

- Mildly strategic or cognitively stimulating

- Nothing too intense or competitive (or offensive)

A couple examples:

- Love Letter: https://boardgamegeek.com/boardgame/129622/love-letter

- Burn Rate: https://boardgamegeek.com/boardgame/3341/burn-rate

Burn Rate is a great example. Years ago, three or four of us in the office would play it every once in a while during lunch and have a lot of fun. Unfortunately, it's no longer published.
Tech Entrepreneur Neha Narkhede Credits Sound Counsel for Her Success
Understood, his mistake was this “base 12, would not act like 12 does in base 10". That statement is mistaken. A dozen would look like ‘10’ but it would still behave like a dozen.
Since all JS is TS, it's very easy to transition to. Similar to how Kotlin runs on the JVM, and is sort of, if you squint, just a nicer syntax for Java.

Anyway, who knows, it's not really that important.

Glad you have some use-cases in mind for Rust :). If you ever need anything, feel free to reach out!
I guess it's a simple distraction to give your brain a break from monotony.

A friend of mine used to search (and share!) some really strange things on Wikipedia like stuff about Rome and Julius Caesar in middle of programming session. I think it just a way to avoid boredom when you've been doing something for some time.

As for the cure I think there is nothing wrong with small breaks. It's the big distractions which cause problems. For that a lot of things can help you keep track like an accountability partner, list of tasks broken down into small tasks, a simple spreadsheet where you mark your work times and break times, etc.
I do genuinely like Notepad++ but it’s hardly unique. If anything, I’d argue that it exists in a heavily saturated market.
Thorstein Veblen's "The Theory of the Leisure Class" (1899). The book was difficult to read for me since the language is very archaic, but it pretty much explained a lot about how class and community is structured.

As an introvert and a social recluse, this book is a goldmine; it eased a lot of confusions in my head about how society and class structures work, and taught me to better avoid the pitfalls of consumerism and peer pressure.
But of that 100 million dollars the bulk was safety testing due to regulation.

So you're right it doesn't make economics sense but for a specific reason. As a society we have to strike a balance between safety and efficiency. And I don't think we've struck the right balance. Many times erroring too much on the side of safety, especially with rarer and more fatal diseases without good current treatments.
Vladimir Vapnik on Human Intelligence and Alan Turing
Does anybody prefer to consume it that way?
And IT has time to check alarms, very unrealistic.
Regulation hurdles were met, and the cost of a plant is overblown. Most specialty pharmacy are made in small labs with a few pharmacy techs, and they can make other things in between this drug.
I think the issue is that of pharma alows the price to drop on this drug, they lose negotiations on other drugs. They don't want a precedence to be set where they drop thier price if insurance companies refuse to pay.
I generally dislike this response to stories. It’s about something significant happening in our world, that’s worth considering and paying attention to. It doesn’t have to have started 4 hours ago.
Most people find it easier to keep commitments to other people than to themselves, because they know other people are going to hold them to account for commitments they care about.
A great README file, explaining things in detail, from the ground up.

Kudos.
Hi all, author here. I'm a long time hackernews lurker but I registered today when I saw traffic to a recent blog post I wrote coming from here.

I wrote this blog post to document my process of building a simple shell using Rust. I learned a lot about how shells, terminal emulators, and the OS interact by going through this exercise, so I hope this is useful to others as well.

Feel free to reach out if you have any questions.
I don't read the gray lady on account of the paywall, but this is something I have noticed somewhat in recent days.
For the usual reasons of distrust of excessive economic power, I have not bought from Amazon for a few years. However, as part of that, I have bought from Abebooks until the last month, when I learned that it was owned by Amazon. I had previously run some quick searches trying to learn who owned Abebooks, and did not find anything. It is also not evident on the Abebooks website. Looking for another source for books, I found an on-line vendor that looks similar to Abebooks, listing used and new books for sale from various booksellers in diverse places. I checked it out and could not link it to any overly large enterprises. That was good, and the other site prices are not obviously higher than Abebooks, but the new site adds $4 shipping on each book, so my cost for used books is now up about 25%. Not good, but I'll pay it to not feed the monster.

So, as both Abebooks and the new site list used books for sale by various bookstores, many of the same books are listed on both sites, and my new vendor might even present a better selection of what I look for. That's good. But some of the vendors that offer the lowest prices deal only through abebooks.com, ie Amazon/Bezos, and they list very many books on the Amazon/Bezos site. Coincidentally, one of them, the Book Depository, shown as being located in England, is owned by Amazon, ships free to the US, but when the packages arrive, they appear to have been shipped from the US.

All of that is business as usual for a megacorp, but another bookshop that sells beaucoups of books through Amazon's abebooks is Seattle Goodwill, a non-profit. This raises my eyebrows because I live in a state near Seattle in which Goodwill's non-profit status has been in question because of high compensation given to its executives. I suspect that the relationship between Amazon and Goodwill may be somewhat complex. Amazon gives its customers free shipping to donate items to tax-exempt Goodwill, Goodwill then sells the items through an Amazon subsidiary, Amazon gets a commission on the sale, what's going on? Goodwill is a non-profit that does 'job-training'. Are 'trainees' not earning Seattle's high minimum wage part of this business? What does this operation look like? Anyone know?
I don't have a problem with the new design, it looks pretty much the same as the old one

BUT IT'S SO SLOW
That is wrong on so many levels.

For one, the idea of "delegate security to a central authority because they know what they are doing" is one that has failed so catastrophically in history it's surprising anyone still considers it a convincing argument. If there is one thing humanity should have learned, it's that centralizion of power is itself a major security problem. Electing dictators to solve security problems does not work.

Then, "we have to give all power to cloudflare or we are on our own" is obviously a false dichotomy. No, people can work together on fixing security problems without the need to delegate power to a central authority.

Also, it isn't hard to keep "a modern system" secure. It's just that noone cares, in part because they think they can just buy security as a product that they somehow plug into their system to make it secure. But that is just a completely mistaken approach. You can buy "IT security" as much as you can buy "car safety". If the engineering of your car is shoddy, no add-on will make if safe, and it's exactly the same for IT systems--and if the engineering is solid, there is no need for "safety add-ons".

BTW, one particular kind of "security" that large organizations are good at is controlling PR. It's just that that is not in your interest as their customer. It's just one of many conflicts of interest.
>>Do you think that supermarkets selling house brands hurts consumers?

Don't dismiss it.
If a $10 store brand shirt lasts you 5 washes, then you were hurt by not buying a $20 brand one that lasts you years. (granted that you may not have $20 at the same time you need a T-shirt)

Same for food items: store brands might be xx cents cheaper but lesser taste, quality and nutrition might put you in red.
How to Almost Learn Italian
The article doesn't go into the most important advantage Amazon has: it has data on what sells well and what markets it should enter using existing brands on its marketplace. With this data, it enters markets and undercuts its competition at the perfect price point.
Operating systems are a bit like the computers used to run them. Years ago when Ubuntu was new your computer would be out of date in two years and an upgrade of the hardware was needed. Nowadays it is not like that and machines older than five years are perfectly fine to use on a daily basis. So it is good that your operating system doesn't expire with no further updates given half way through the machine's life.

This is even more so in server-land than desktop, a functional web server that has worked for years shouldn't need upgrading to a new virtual machine so often. Two to three years can fly by in ways that didn't happen when hardware had to be constantly upgraded.
Us tool wielding humans are gonna get wiped out just like those insects. Whenever the forces of nature hit us our tool wielding seems to matter very little.

My point re: the fishery collapse is that all the tool yielding people didn't forsee the collapse and when it happened were unable to deal with it effectively. You're not gonna have 20 years to figure stuff out if climate changes dramatically, ecosystems collapse or some feedback loop kicks in. The scale/force/power of these changes is well above our current ability to engineer and our illusion of power is going to disappear very quickly once our society and infrastructure disappear. The romantic notion of 50 people in a bunker surviving and continuing the human race while the oceans turn into acid .. not gonna happen.
Your correction is accurate.
I used it for a long time but eventually I realized that it's only killer feature was the file tree on the left which most editors have anyway.
Didn’t we cover this in another thread?
Most (all?) California residential including apartments are wood framed for earthquake survivability of the residents. https://www.nytimes.com/1999/01/31/weekinreview/the-world-on...
I see skeuomorphism as an excellent idea.

The human mind is built to build models... We are constantly building models of the world and predicting how that world will work. When you have a digital world that has no rules where every time you do something it behaves in a new and different way it's surprising... and it is also really stressful. Your mind can't build any models. That makes it hard. Everything is an adventure. But when you are trying to get something done you don't want an adventure, right? We want things to behave in a predictable way. It'd be like, sometimes I put something on the table it doesn't sit there, it flies up to the ceiling.

Skeuomorphic design helps users make mental models. The above paragraph is actually a from Google talk on Material Design! They understood the theory well, but their implementation is lacking.
I think I meant less for forecasts and more for weather apps and thermostats. I really think it could help with adoption. But if it’s not warranted by the error then maybe I’ll reconsider.
15 seconds to load interface, 5 seconds to mail and reply.
Mac, Google Chrome, Firefox, or Safari, 22MB/s download/upload, 2.9Ghz cpu running nothing else.
If I search for Coca Cola and Amazon shows me "Amazon-Cola" and I ultimately scroll down and see Coca Cola -- no big deal. If Amazon decides to not sell Coca Cola at all, I'm still not buying "Amazon Cola." If you're shopping for name brands already, there really isn't much discovery necessary. If you aren't, then the competing brands should do something to differentiate themselves -- lower prices, higher quality, better advertising perhaps. If I'm buying a generic product to begin with, I don't particularly care what "store brand" it happens to be. And, if we want to talk manufacturing -- the "brands" are all that could be "hurt" -- the actual manufacturing of the product still happens, regardless of who sticks their label on it. A wheat farmer doesn't particularly care what brand the distributor sticks on the final package. He's still getting paid the prevailing price of wheat.
It all depends on the US city and what the public transportation options are. If it's mostly bus, then people will prefer to drive if they can.
I wouldn't call Paxos on the decline. It has several nice properties that Raft lacks[1]. However, implementing it correctly is more brutal than Raft, which is cut into easier-to-understand components.

Also, the paper introducing Paxos[2] is famously obfuscated, while the Raft website[3] trivializes the problem, and has ready-to-use libraries.

As a result, there are more recently-developed systems in Raft than Paxos, but I expect there is more volume hitting Paxos systems than Raft ones in the world.

[1]: http://rystsov.info/2017/02/15/simple-consensus.html

[2]: https://lamport.azurewebsites.net/pubs/lamport-paxos.pdf

[3]: https://raft.github.io/
> You can run it on Minikub

Thanks for the tip. I just started down the k8s path from bare metal cluster and will try this.
The most extremist state in the region is the house of Saud. To come here and try to legitimize a genocide? Wooooow just woow.
You also see it in compulsive gambling. Sooner or later the odds will pay out.

Just gotta keep chasing that magic.
Then consumers win. The competitors can lower their prices/increase their quality/improve efficiency and consumers get to buy better products for less.
*existing
I don't know enough about gene therapy really say what could be improved. If there are common aspects of the process that could be "factored out" I think it would make sense for governments to research that and help streamline approval that way. But that's looking at it from a programming point of view--I don't know enough about the biology to know whether that makes sense.
> I don't think he understands pricing at all. Market price isn't arrived at via a rational process. It's an inherently social process arrived at by negotiation between producers and consumers.

Are you suggesting that prices don't have anything to do with scarcity and are just set arbitrarily by social forces? That doesn't seem quite right.
How the Internet Turned Bad
Vertex, a JSX Server Side View Engine
Works on ios chrome too, but for both it breaks down when a call/gps banner is up there
NSA always wanted to be a so-called global observer. CloudFlare is in the perfect position to be the global observer and it sell it as a feature, not a bug.

NSA budget is big enough that it could buy CloudFlare 10 times a year, or have thousands of undercover agents.

Every "target" website that is not using CF can be cheaply DDoSsed until it switches to CF or disappear.
I'd recommend reading The War of Art: https://www.amazon.com/War-Art-Through-Creative-Battles/dp/1...
It still wouldn't get the drug to the people who need it. Most of the cost involved is in getting it approved by the authorities for human use.

There's nothing stopping people from manufacturing the drug for personal use, other than that it's likely extremely hard to make.
> Namely that a retailer will make it explicitly clear, with obvious branding, what is a "store brand" and what is not.

how are brandings such as Kirkland Signature(Costco), Simple Truth(Kroger) or 365(Wholefoods) any more obvious than what Amazon is doing with "our brands"?
No, not here.
The amount of information in a message is defined as the unpredictability of the message.
"The absolute difference between us and San Francisco is we believe in economic diversity, we believe in ensuring there's a vast supply of affordable housing,"

I think the bigger difference is the commitment to effective mass transportation in the whole tri-state area, which is a huge help in mitigating the affordable housing problem.
The irony of this being on hackernoon, which hates mobile users.
If the processor supports unaligned reads, sure, you could say that, though it still technically violates the C standard. Otherwise, no.

A typical issue would have code like this:

foo = * (bar * )baz; // baz is a char pointer into a binary blob, and bar is a type that needs alignment

If the data were all properly aligned, then most likely there would be no desire to write such code. The correct types would be used.

Aside from gcc abusively optimizing, the above works fine on x86, PowerPC, and modern ARM. It does not work on older ARM.

That sort of code is everywhere.
RAMQ [Quebec Health] does negotiate separately from the rest of Canada... but they don't have the money. They don't have the money for top-line cancer treatments, and they so severely underpaid optometrists that the optometrist union opted out entirely. There is very little chance that even at $250K a dose (which is an imaginary figure! the sellers have said they will not reduce the price at all!) a negotiation could be reached.
Well the point is it's been over a decade. They've done a lot of trying with little return.
Other tools are not always an option. For example, I used CrossOver(Wine) to run WinMerge which had a plugin to support our company's workflow. Wine allowed me to stick with Linux without any time wasted.

Over the years, I've tried several native Linux alternatives. All of them would require a huge time investment to replaced the missing features.
No. I was joking. :-P
Agreed. Law enforcement cooperating across borders is fine, but extradition is a whole new level.

Of course, it isn't completely black and white. If it's alleged you killed someone in one country, and then flee across the border, should you be extradited? Given enough evidence, yes, that sounds just.

So how about if somebody mails a bomb to an address in another country, is it just to extradite them? It's hopefully illegal in most countries, so why not try them in the country in which they were when they committed the crime, in this case building the bomb?

Cyber-crime also seems clear cut, but there's equally grey scenarios, like hacking utilities to cause harm. But for copyright infringement it's hard to see how it's just, even it it was on a commercial level.
> is of questionable effectiveness --- it improves quality-of-life metrics but not necessarily clinical ones like blood fat levels

"Although based on a small number of patients and episodes, overall pancreatitis incidence up to 2 years post-alipogene tivarvovec injection decreased by 5-fold"

"However, several signs of clinical efficacy independent of plasma TG were noticed up to 2 years after LPL gene transfection and raised the possibility that TG-rich lipoprotein characteristics, particularly the size, lipid content and kinetics of CMs, rather than plasma TG concentration per se, are the best surrogate markers of pancreatitis risk in LPLD."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956470/#!po=37...

From what I read, 2-year follow-ups seem to find continued (post-26 week) activity of the inserted gene.

So it's inaccurate to say there were no clinical improvements.
> ...I feel I have way less handle on a gallon than on a liter.

What's so difficult? A handle is 1.75L or about half a gallon...
LetsEncrypt, no. they don't ask you for your private key when you get a certificate, so they can't decrypt anything.
I know a few people that live in affordable condos. You can only buy and sell to people in a certain income bracket. The people I know that have them got them as grad students but had very wealthy families.
Pocket is a great product. It's not perfect, but I enjoy using it.
This is cool, but please improve your text to speech. check out things like http://mary.dfki.de
TBH, it sounds like the govt regulation for the drug to even get approved are what drove the cost up. The product was essentially made before pharma even had to lift a finger, but they made them jump through a lot of hoops to get it to market. That's the $100mm they are trying to recoup. Also, I think a lot of folks are missing that the disease is not necessarily lethal when diet is controlled. Just saying, that's all.
Given that Resume Driven Development is (likely) heavily influenced by surveys like these as developer look at them and think "maybe I really should make the switch to everything JavaScript?". If what you say is true then js could actually become more popular than it really is in reality in some sort of bizarre, comical, global software development "fake it till you make it" kind of way.
> No recourse to public funds applies to only specific work immigration permits

No it doesn't.

It can apply to students, spouses, people who are granted leave on the basis of family or private life, to people who have exhausted their appeals to leave, to asylum seekers; etc.

http://www.nrpfnetwork.org.uk/information/Pages/asylum-seeke...

https://www.childrenslegalcentre.com/resources/no-recourse-p...

This hits children because free school meals are sometimes gatewayed by access to child tax credit or working tax credit, and those are public funds.