skysight-inc/HackerNews huggingface dataset:
Or program the T-cells to attack mesenchymal cells that are producing the defective ones. I'd wager that the process would still be much more difficult than targeting cancerous cells, and certainly be very complicated.

But, there's hope for other diseases, though the article is focused on cancer:

> Not only can this technology help revolutionize TCR-T cell therapies for cancer, but it will also be a powerful tool for discovering other immunological agents, including antibodies and CAR-T cells, and for elucidating new immunology and cancer biology at a depth not possible before.
QA testing is a pretty low barrier to entry gig. It's not exactly exciting work but it'll pay 50k+ per year and is a full time job usually (so benefits). The job will vary depending on where you go though. Some places will just need people to click around an app, other places will require some scripting/basic programming skills. It's just about finding the right company
This sounds similar to https://www.conviva.com/precision/

Unfortunately you need to know a lot more and the devil is in the details. Supporting the various streaming devices/browsers is a huge pain in the ass.

Full Disclosure: I worked for both Conviva, and Akamai.
"There needs to be a paper trail. Newer technology is not the answer for voting."

I agree. Voting systems need to be extremely simple and understandable - and auditing the system, or the votes, needs to be a task that any person pulled randomly off the street could accomplish.
AT&T to cut off some customers' service in piracy crackdown
It makes some sense because wages come with a lot of benefits guaranteed by labor law while self employed people take a lot of risks but in general I see progressive taxes as a bad idea inviting scams. It's better to tax consumption of luxury goods at higher rate and/or use more tax revenue to fund social services mainly poorer people use.
Internal browser support for local caching based on a hash versus "where it came from" would be helpful as well.
Show HN: Affinity.js – A simple view component library with store
with affinity you can make multiple apps (components eventually) and store (ala redux) - while a store can be shared through apps.

This started as a case study and as a small reusable code for creating self contained dom elements with functionality - during the time of development, ideas and inspiration came from angular, react and vuejs.

suggestions and feedback is mostly welcomed.

The interesting challenges were finding ways for these topics:

1. create a component lib using dom and js only, without any 3rd party .

2. producing semantic html in dom .

3. allow template micro syntax (using @click to bind an event listener) .

4. allow reusing custom elements within a component's template .

5. creating a simple store interface and auto connect it with
a component to allow re render whenever the store changes .

any feedback and suggestions are welcomed

https://github.com/orizens/affinity
How is it supposed to work as a placebo if you're told "hey, this is a glass of fresh water: drink it. And by the way, it's free'.

In other words the lie is integral to the working of the placebo. This is the whole source of the issue.
Probably not even religion, but anything that unites a tribe. Religion is useful if you're looking to invade a Muslim realm, but race, class/status, and political ideology are all popular rationalizations for motivating attrocities.
Many are prepared to take action and actively do so. They are subsequently vilified by politicians and media for not falling in line and voting or taking other acceptable (and ineffective) actions.

Strikes and large protests are not encouraged in mainstream discourse and the principles they represent are not available as an option to vote for.
I see, that looks like a good forum. Thanks.
I found a slightly better one that also blocks google UTM trackers as well, here:

https://addons.mozilla.org/en-US/firefox/addon/utm-tracking-...

and source here:

https://github.com/jparise/chrome-utm-stripper
Why the Gender Gap Gets Worse–Not Better–Among Senior Engineers
The idea is that Swift will still use a reference counting GC as the main way, however there is the additional possibility to use ownership annotations for low level control, but not as strong as it is done on Rust’s case.

There are a couple of WWDC 2018 sessions about it.
Are you thinking of something like BitTorrent? Why ask for the whole file from a list of hosts when you could ask for any bit of the file they might have?
I am not opposed to having mixed groups. They have a lot of benefits in many settings. I just don't want to force it. There are people with various views about how various activities should be and how children should be raised. Let them do w/e they think is best.
Ask HN: What are some hacks of real founders who did things that don't scale?
Inspired by Paul Graham's phrase, I’m curating an open list of hacks/stories of real founders who did “things that don’t scale” to power through their initial startup days.

What are some of the hacks you have heard or have personally experimented? Thank you in advance!
One thing to note here is that it's not as if it's just coincidentally difficult for young people to vote, it's not just an unavoidable fact- it's part of an intentional strategy. For certain portions of the American ruling establishment, democracy itself is an enemy to be vanquished by any means necessary. Review the history of racial segregation and you will see obvious parallels to many forms of voter suppression today. This is the next big issue facing the USA, from my point of view.
*Bacteria and graphene nanoribbons 3D printed on a mushroom generates 65 nanoAmps.

I'm going to go out on a limb here and say that the energy it produces over the lifespan of the mushroom is several orders of magnitude less than goes into manufacturing the 'bionic' bits.

I can't find how long A. bisporus lives after it caps but I'm guessing weeks at best. I'm not paying for the paper so I have no idea if they mention voltage and I have no idea what voltage might be capable of being produced by I'm guessing it's going to be considerably less than a boiled potato (5ish volts)... sooo...

Almost certainly less than 3.25e-7 watts, so you're talking tens of thousands of weeks to even get a watt hour.

Just the two of us visiting the link likely used more electricity than one of those would produce in a century, if not a millennium or more.
The weird thing about homeopathy is that it's advertised as selling poison, but actually isn't. One of the ridiculous premises is that "like cures like", so it should be poison, but then there's the other ridiculous premise of diluting it to make it more powerful.
A hundred and thirty comments and zero uses of the words "gene" or "genetic." Nobody else thinks evidence connecting the presence of a gene with susceptibility to the placebo effect is interesting?
Top Black Friday and Cyber Monday Web Hosting Offers
Every company I've worked for in NY/NJ has had the day off... except my current gig for an Italian company. Go figure.
> Getting ignorant people to cast poorly-informed votes does not help our society.

What makes you think this is not already happening? Why would phone voting make it worse?
Can't you do that with DNS records where there are multiple IPs on a A record?

Basically, we're already doing this for fault tolerance and load balancing within a single CDN. Except that currently we randomize the IPs. To enforce priorities, you'd want the IPs in the A record at least partially ordered by provider.
Elevate side channel attack to another level.
It was 40% effective for _both_ groups. Meaning the "actual treatment" might actually be doing nothing.
It's good to note that non-placebo treatments don't work on everyone for every problem as well.
Here's one popular example:

Recruit new users by manually installing your s/w on their computers by @patrickc” link: http://paulgraham.com/ds.html
How much does it really help to have a noncorrupt leader of government when a large part of the bureaucracy below them is corrupt? Rooting out corruption is a terribly difficult problem that takes decades.
Profiling: the case of the missing milliseconds
That's it, I'm moving my startup under my stairs.
I have a fond memory of the original redhat distros involving a closet. Sometime in the mid 90's, I was installing RedHat on an old (even for the time) 486/33 server that we had managed to acquire with the understanding that it be relocated the next day to a closet in another building across campus. Since the machine was actually on a desk, we thought we should do the install before having to move it to a cramped space. The installation ended up taking like 18 hours on that box, and it came time to move before it was finished. So we unplugged the UPS and had a bunch of people walk the thing across campus along with its tiny monochrome monitor still showing the RedHat installer filling up progress bars over and over. It prompted a lot of questions and strange looks. We were worried that the batteries were going to give out, but we made it. The machine carried on dutifully for many years longer than it should have. The Redhat distro along with rpm really made Linux a workable and supportable platform, and they deserve a lot of credit for their efforts.
WooCommerce Product Filter Plugins
Monitoring the blank landscape for signals of malevolence is one thing. But targeting a specific landscape for an attack is another thing entirely. In other words, it is easier to cause an action of attack than it is to monitor, forewarn or prevent somebody else's attack.

The possibilities are now open to detect presence behind doors or to shoot people deeply embedded in buildings.
This is the reason why chatbots did not live up to the hype. It is hard to have an agent that offers solution in a domain as well as being generally conversant.
That’s a bad way of phrasing it. Democracy requires a well-informed electorate to function. If the electorate is badly informed or misinformed then it doesn’t function as a democracy, but as a (Propaganda-ocracy?). The complexity of the world that leads to economic specialisation also precludes informed decision making by a conventional electorate. I don’t have a solution to this yet. I don’t even know if there is a solution — I’ve heard that humanity has swung from democracy to aristocracy and back over the ages for this exact reason, but the very specialisation that has me concerned is also making me unsure about that.

One of the modifications of democracy we discussed in A-level philosophy was getting one vote for existing, another for having a degree, another for being a parent, etc.
1993-1994 was before the first flush of "dotcom 1.0" era VC money, which showed up in the 1996-2000 era before the big crash.
Ask HN: Any books related to machine learning or AI
similar to "Data Science from Scratch" or "Programming Collective Intelligence" where no external libraries are used to implement the algorithms?
Didn't someone in SV say "Software is eating the world"?

https://en.wikipedia.org/wiki/List_of_largest_pharmaceutical...

I suppose 34B is a good run. I mean its not $110B, but its not Biotech so.
But we can localize it that precisely, and cheaply. In that particular experiment, they found that the areas of the brain that are commonly associated with raw visual input activates precisely whenever an image appears, subliminal or not. Then a large, delayed negative wave reliably appears in the frontal lobe only when the patient affirms that they saw the image. It's using objective methods to confirm the subjective.

These sorts of experiments are helping with making prognoses of whether a patient recovering from a coma will remain in a vegetative state, or if they'll regain consciousness in time.
Right, more correctly I should have said:

Yes, but in trial where patients may receive placebo, the patients always consent to be randomized to the possibility of being treated with placebo.
meh. I had a 2007 mini that crapped out one month after the guarantee expired. Took it in for support and they told me to buy a new one, not interested in taking it on. To be fair this was a specialist apple dealer. At the time there was no local Apple store.

My general experience with Apple products has been 50:50 some good, some bad, Apple is nothing special when it comes to quality. Better than some is about all I can say.
So IPFS?
I would imagine adding one or more friendly WiFi transmitters as illuminating sources even on the outside would greatly help the accuracy.
Presumably, they also work on Tuesdays, right?
And Rails could have been written in C. The reason why it wasn't should be clear. Different languages enable different ways of thinking, and what is hard to express in one can come out easily in another.

This is valid for both programming and human languages.
trial only.

you would have to consent.
It's a complicated issue to be sure, but developers also benefit from a platform that has high trust among users. I think users are probably much more likely to try out new apps and even pay for them if they know ahead of time that the apps been vetted, the payment processor is secure (and already has your details), etc.

Not that there isn't crap on the iOS App Store, but I don't think it's controversial to suggest that the Good to Bad App ratio is better there than on the web as a whole.
... no? At least, that's not what I inferred from the Wikipedia article.

If you want to dig into the details, the report is at https://spacesyntax.com/wp-content/uploads/2011/11/Hillier-S... . A quick search finds the following in the conclusion section:

> Cul de sacs or grids?

> The principle that larger the numbers of dwellings on the street segment reduces the risk of burglary, applies both to cul de sacs and grid like layouts. Small number of dwellings in a cul de sac are vulnerable, especially if the dwelling are affluent.
Maybe when people talk about "free will", what they are really talking about is the ability to deviate from the simplest conception of an evolutionary strategy.

For example you wouldn't say a plant has free will. It just sits where it is planted, collecting sunlight, water, CO2, and minerals, and grows as specified in its genome. It doesn't deviate from the evolutionary strategy of its species.

You probably wouldn't say an ant has free will. It can move around, sure, but it seemingly does so according to a complex set of rules that are consistently embodied by all members of its species.

Does a dog have free will? I think we're getting closer to the line. A dog can clearly make choices against the simplest evolutionary strategy. A dog needs food to eat, it's driven to prefer certain foods... but some dogs can choose to let a tasty treat sit on the table (or even on its nose!) without consuming it. Some dogs seem to act in a way that we would call altruistic, endangering itself to save a human child, for example.

And of course, humans are capable of making all sorts of decisions that seem counter to a simple conception of an evolutionary strategy. On the positive side, choosing to forego reproducing in favor of pursuing some social goal, like a career. On the negative side, choosing to kill someone despite knowing they could be caught and punished (and therefore not reproduce).

And I think the opposite holds too--when we imagine a being without free will, the defining characteristic seems to be that it always follows a rigid set of rules, with no possibility of deviation.

I keep referring to the "concept" of a simple evolutionary strategy; does that mean this is not a rigorous definition of free will? Well I would say that free will is itself a human concept, so I think it's valid to explore its meaning in the context of other human concepts.

I think it's entirely possible that humans are actually deterministic and predictable, but the rules of our behavior are so complex that we could never know or apply them in a practical way, the way we know and use the rules that govern plants, for instance.
This is a fascinating idea - it's definitely possible, though easier for some groups of people than others (I don't think I'll be able to hire doctors for $25/article). I think the human and AI analyses would contrast each other nicely -- the model would estimate how well people will react on average and the human analysis, although idiosyncratic, will pick up on more abstract qualities of writing, like the flow. I'll put this down as a feature to implement in the long-term -- thanks for the idea!
Java x Web crawler
I'd be curious to hear HN's thoughts about this in relation to the chronically ill, such as those featured on Netflix's Afflicted series (https://www.netflix.com/title/80188953).

> Wi-Fi and electricity trigger Carmen's strange symptoms. Jamison hasn't left his room in two years. Bekah lives in a van in the desert to avoid mold. Star has been diagnosed with a dozen different conditions.

How much of it is real, how much of it is the mind making it real?
NEGAPEDIA – THE NEGATIVE SIDE OF WIKIPEDIA
Yer a wizard Harry!
The site you linked uses tweets with certain hashtags related to publishing in the app store as "data". This is highly inaccurate, not statistically profound, biased, easily manipulated and not conformable.

(That's why you're downvoted, probably)
Democracy only works with a well informed voting base, and while you may disagree with the current state of politics, it has always been my belief that people that do not know the candidates or issues should abstain from voting. I will often vote in some races but abstain from others, simply because I don't know the issue or candidate well enough. I wish more people would do that.

Making voting easier for the highly ignorant is not a good path. If someone isn't willing to mail in a ballot, drive to the poll, etc I don't think they care enough to know the issues.

I know there are some circumstances where people can't get off of work, but those people generally just don't know their own rights. Most states legally obligate employers to give people 2-3 hours off to vote.
Moscow to some extent, and traffic is disaster. Rings are especially jam-prone.
Although hash tables are used internally by libraries, they are not directly used by the application developer. When was the last time you had to hand code a hash table?

Unless you are a library developer, its an example of a task and knowledge that will never be needed. If its something that is never used in that particular job, why ask it in the interview in the first place?
As a fan of Gould, I was very disappointed to see that it's likely he committed scientific fraud in service of his political convictions.
Not necessary apparently, https://www.health.harvard.edu/blog/placebo-can-work-even-kn...
Most people are not going to abstain if they can vote from their couch, they will vote straight ticket.
Honestly, I don’t think voting by app is inherently a “horrifically bad idea” – just that Voatz’ implementation is horrifically bad.

Biometrics are going to be almost impossible to do in a non-invasive and secure way for now, so cut that part of the pitch. Blockchain may not be an entirely round peg in this square hole, but there are other cryptographic architectures that probably make more sense (I am not a cryptographer, but maybe go talk to a competent one before just deciding on blockchain).

Obviously, without the two big buzzwords of blockchain and biometrics, you’re suddenly at a big disadvantage for VC money, but if mobile voting is ever going to be feasible, it’s going to need a considered, end-to-end approach that isn’t some MVP built from off-the-shelf components and off-the-shelf ideas.
Can anyone help me figure out if I'm of the variant of the rs4680 allele that is most placebo respondent if I have my 23andme results (I am variant G)?
Death toll from Chernobyl is presently at 31 with an estimated number of 4000 premature deaths.

So, yeah.
I think placebo can be self-administered. I can make many pains decrease in intensity (or sometimes go away) just by thinking about it.

Last year I fell while mountain skiing and was in great pain at first (could barely move, standing up from lying down was excruciating, etc.)

The first day I didn't take any pain killer; the second day I did but it didn't really help. The third day I stopped taking the pills and just kind of "decided" I wouldn't suffer that much.

The pain didn't disappear completely, and it still hurt too much to get back on skis, but it stopped being so intense. When I got back home I did an x-ray exam and MRI and found I had broken a vertebra in two, that had lost 25% of its height. The doctor was super surprised I could walk normally and said: "do you not feel pain". I said I did but it was very manageable. She didn't investigate and just said "ok then, good for you!"

Also, I used to get hiccups that lasted a long time (30 minutes); and then I discovered you can make them stop very fast by being super calm and concentrating. Not only that, but since I found this out, I barely get hiccups at all anymore.

I think we can consciously control much more of our own body than we think, and we're only scratching the surface.
If this was a subtle starship trooper reference, bravo:

https://www.youtube.com/watch?v=kdrjzE1SE58 (depictions of violence, satire)

For those that don't know, Starship troopers is a scathing satire about how "war makes fascist of us all".
Interesting - would you mind talking a bit about why you chose Algo for professional use and Streisand for personal use? I've been meaning to research them both more closely, but just getting by on manually configured SSH tunneling for the time being.
Argument distinguishes whether you're being identified by an "us," or a "them," and in the medieval small town case, it is an "us," where at scale, it is necessarily a "them."

When you add urbanization and modern identity groups, you are going to be a "them," to someone, and providing them with a technological weapon begs to have the balance corrected.
From a throwaway account, lol.

Page 54 in the report from the ICO: https://ico.org.uk/media/action-weve-taken/reports/2260277/i...
I guess SELinux/SVirt would mitigate this
Dave Patterson on Computer Architecture
Headline should reflect the original article ("Ads just work").

Some thoughts...

Humans, in general, seek to improve their environment. One might paint their home, put out plant pots, tidy up, whatever else. In private spaces this all works out.

Advertising goes against all of that. It effectively states 'I can put this ugly thing here, and it'll increase my local happiness (because I don't have to see it), so screw the global happiness'.

I stated a similar form of this argument in another thread. There's a huge banner ad (larger than a person) close to my home, on a bus stop. The last I saw it was some sort of advert for supplements of dubious medical value.

My nice walk to the post office or whatever gets interrupted by this nonsense every time I go outside, big colourful unnatural full-face things reminding me that people are being duped into buying crap they don't need by other people that don't care about them.

I think, and hope, that one day we'll realise that many forms of advertising are effectively mental abuse.
This is going to sound super pedantic, but "Maritime" provinces in Canada means Nova Scotia, New Brunswick, and Prince Edward Island, and specifically excludes Newfoundland. You want "Atlantic" provinces. This is kinda a bugbear for Newfoundlanders. Don't worry, I'd still invite you to my kitchen party.
It's not random though - it is probabilistic. And even if it was an internal 'RNG' it is is still _their's_ not someone else's.
About 60% of toilets in Russia are how we call them "free fall toilets". Because everything that goes out has to fly more than 3 meters down the hole. My grand-grandma used "human wastes" to manure her garden each spring and it flourished. I guess it won't work nowadays because you've got to eat healthy food to produce healthy waste. But still... $200M?.. Hmm...