skysight-inc/HackerNews huggingface dataset:
While relaxing while playing, I found after a while I was also playing the game in my dreams.

While that would probably help improve at the game, I was thinking I needed to back off and take a break.
Well hopefully we're space faring by then!
(2016) tag.
IMO this is exactly what we ought to do. A big problem for the homeless is that they become poor in a place with no jobs for them, and then they get stuck. There are lots of places with shortages of the kind of labor they can offer, and making travel easier for them is a great thing to help fix that market failure.
> #1 rule of sales is that people don't buy products, they buy transformation.

It is so, and yet here I believe is the point where ads/sales become dishonest. I'd gladly seen all of them banned past this point. Ethical ads should communicate existence of a product/service, the products it solves, and the special features it utilizes. They shouldn't abuse people's emotions.
I feel the opposite, except when it comes to medicine.
I wonder what we can do about misfolded proteins?

I kind of skimmed the article and went to the Wikipedia link they included for the protein in question. I don't really understand Parkinson's pathology and I've never heard of this aspect of it previously.

But I have a genetic disorder that involves a defective protein and I can speak generally to pathology of that sort, though I can't say for certain how well this applies in this specific case. What I skimmed sounds vaguely similar to the pathology I have read up on for my own condition.

In my condition, what happens is you have two of, say, 1600 or so different alleles (or two copies of the same one) that impact the coding of the CFTR. The CFTR is a protein that forms a cell channel that manages traffic of specific molecules into and out of the cell. The manner in which it is defective varies, depending upon the alleles.

CF is a progressive condition. In other words, it gets steadily worse over time.

I have never gotten any kind of logical explanation from the medical literature for this well established fact. I did my own digging. (I actually was trying to understand something else when I tripped across the following info, but I'm sure no one cares.)

It turns out that derangement of cell chemistry in terms of pH balance and/or salt causes protein misfolds. CF promotes both of those chemical derangements. My inference is that as the body gets more chemically deranged, you see more misfolds. As you see more misfolds, you have fewer functional CFTR channels. This creates a positive feedback loop, aka vicious cycle. Thus, "The normal progression of CF" -- ie you get steadily worse over time.

The misfold matters because basically the way it is folded is what turns a protein string into a useful tool for the cell. Think of Legos or something like that. I mean, that's not a good example. There are toys out there that can be strung together and then bent or whatever. I just can't think of the right name of a good brand.

But you have protein bits that get strung together and if they bend the way they are supposed to, you have a useful tool to accomplish important work in the cell. If they don't, you have a pile of junk that the body needs to expend additional resources on to melt down and either recycle or dispose of as trash.

So the odds are good that Parkinson's involves some specific vulnerability different from my condition and it is made worse by chemical derangement within the cells. Drugs (or dietary changes) that corrected the chemical derangement or prevented the chemical derangement would likely be a good thing to look at.

Correct the cell chemistry, you should see fewer misfolds. Fewer misfolds enhances performance, if only by not wasting resources on churning out a pile of junk proteins that can't be used and now need to be disposed of somehow.
The camera already functions this way. The light is connected to the actual power of the camera and cannot be disabled unless the camera is also disabled. The microphone, to my knowledge, doesn't function like this but I don't think it makes sense for it to function like this as the microphone doesn't really need power outside of what's provided to the amps and DACs inside the machine. It would be too easy to work around. Any membrane capable of vibration would be able to be used as a microphone, including the laptop's speakers, so it'd be more work for little gain.
I can get an appointment with my doctor, quicker than I can get a programmer assigned to a task at my workplace. I go through fewer gatekeepers at the doctor's.
Do you have a lawyer yet to sue the ashram? You were fine before and after spending six months there you have a debilitating disease. Clearly there is a causal relationship.
I have sunk an absurd number of hours into games in my life, Diablo in particular. I still remember some of the goddamn uniques on my sorcerer from the first one (Dreamflange, Thinking Cap and Najs Plate or Cape). And while I'm totally flabbergasted by the emotional response, I'm not very judgemental about it. I don't get deep emotional attachment to sport teams or TV shows either. But the sheer fury and vitriol and the paranoia fuelled fantasies about evil journalists are a little bit unsettling to be honest, especially because we both know that the stuff we get to see is just the tip of the iceberg.

I simply can't help noticing the striking difference to the reaction to SyFy's cancellation of The Expanse.
Mark Russinovich is a treasure.
The really terrible pop-sci write-up says because the antibodies are smaller. The actual publication doesn't given a reason for using llamas. The rationale discussed doesn't hold together, either, since nothing in the study is about "small ab penetrating deeper."

To quote the actual study:

"Moreover, most vaccine-induced antibodies are directed against the highly variable head region of hemagglutinin (HA) and are strain specific. However, broadly neutralizing antibodies (bnAbs) targeting influenza HA have been isolated and characterized (8). Several bnAbs have entered clinical trials as therapeutic agents, but their use in influenza prophylaxis remains elusive because of the incomplete coverage against circulating human influenza A and B viruses, which necessitates administration of a bnAb cocktail, and the need for multiple, high-dose injections for protection throughout the entire influenza season. High serum bnAb levels are required because of poor distribution to the upper airways. We present an alternative strategy for long-lasting protection in which single-domain antibodies (sdAbs) (9) with influenza A or B reactivity are linked together into a multidomain antibody (MDAb) and expressed at the nasopharyngeal mucosa through the intranasal administration of a recombinant adeno-associated virus (AAV) vector (10, 11) encoding the MDAb transgene."

Their whole point was to take Ab that target highly-conserved regions and link them together into a, let's call it, multi-tool ab that has a variety of ways of hitting highly conserved regions.

Nothing at all about that approach suggests using "smaller ab" to "penetrate deeper." It's true camelids produce single-domain antibodies which are much smaller than the multi-domain antibodies humans use, but that wasn't the goal of the study: on the contrary, using peptide linkers to string together ab sounds like it accomplishes quite the contrary.

I think the actual rationale is: "we wanted to string together a bunch of different antibodies to maximize the likelihood of our construction finding a target, and human ab are so big that if we string them together it'll be useless - so we strung together a bunch of small, highly targeted ab, whose final size will still be small enough to allow the multi-headed hydra to interact with viruses."
I recently learned that LEDs can be used as light sensors if connected to an ADC. I wonder what other mechanisms there might be to capture sound that a determined adversary (i.e. government organisation) might use. While speakers can certainly be used as microphones, I doubt they'd be connected to an ADC so probably won't be useful, but what about the multitude of other sensors?
> I don't think this bill is going anywhere

You can actually also tell that by the fact that the article states that privacy regulations are backed by FAANG or similar et al. They think that an eventual bill would be so watered down or not matter that they don't even mind stating up front that they support such a bill.

This is similar to a technique that I have used with my wife. She wants to know say if we can do this or that at some future date. I know that we won't end up doing it so I don't put up a fight (even though I don't agree) and I actually support it fully. Later if it looks like it might happen I use my initial agreement to change the exact terms and she is less likely to think I am gaming her. Or figure out some other way out.

Curious if others think this is wrong and sneaky or smart.
> Believing that these things can easily be broken apart is an illusion.

It works really well were I work. It's led to an extremely bottom up culture were engineers want to stay forever, because they feel like management isn't getting in their way or compromising technical decisions.

> Teams need leadership, not three leaders.

I'm not advocating for shared responsibility. What I'm advocating for is separating responsibility such that each person knows exactly what they are expected to deliver. The manager is expected to help his team perform and be happy. The TPM is responsible for delivering the product the users want. The tech team is responsibility for delivering a product as quickly as possible that is maintainable and bug free and meets the requirements set by the TPM.

In your model, managers argue with the tech team, which causes people on the tech team to quit or become frustrated because the managers can't understand all of the details and still fulfill all their managerial duties.

> It’s how product believes one thing and engineers believe another

The role of the TPM is to make sure the tech team is building what the user wants. the TPM should be synchronizing with the user and the tech team, making sure this doesn't happen. It's their responsibility.

> Teams need leaders and leaders need to be accountable for results.

Agreed, teams need leaders who are focused on doing one thing, and one thing well. They should not be backseat architecting or leading the technical direction, unless they are the tech lead.
My company (major telecom) literally gives away camera covers. Surely they'd do same for mics if there was a convenient cheap way. There's plenty of rumors about mics & cameras being commandeered by hackers & secret agencies.

Apple gets ahead by actually securing mic access. Lots of people want it.
I didn't realize the CFTC has effectively banned prediction markets. Does anyone know the background to this?
I think it's a fine analogy. But the author doesn't go far enough. My thoughts here: https://blog.alexrohde.com/archives/432
The Epidemic of Islamic Sex-Grooming – Christian Concern
This is the bullshit ads try to sell you. Few of the products have actual ecosystem of shared values, much less have those values shared by the company making the product.
Depends – the missing linker for the JVM
If you can really sense EM fields of that kind without knowing that they are there, (a double blind experiment) then I believe there is a lot of money to be made.

Edit: apparently the most famous, Randi’s million dollar prize has ended, but I’m sure there are others.

https://en.m.wikipedia.org/wiki/One_Million_Dollar_Paranorma...
On macOS, Go just straight up prevents the use of DYLD_INSERT_LIBRARIES (the equivalent of LD_PRELOAD), because macOS runs dyld and this mucks with some sort of threading setup.
Nice! Kudos for also making it open source. Direct link: https://github.com/giekaton/hacker-dig
There was something here on HN earlier this year linking WiFi to problems (health related but I don't recall what exactly). To call it a conspiracy theory is a bit much.

On related note, I've wondered if the circulatory system would function as antennas of various lengths.
And sounds more scalable too, if they wanted to start applying the same principle to other components like accelerometers, light sensors etc.

The point (it seems) of the T2 chip is that it's isolated from the main system and has far fewer opportunities for exploitation, while leveraging efforts already expended for the iPhone. In my mind the eventual goal of the T1 / T2 etc chip line will be to do everything for a Mac that an iPhone does—storage, webcam control and encoding, audio in/out, fingerprint reader, sensors, battery monitoring, power management etc—and then expose it all to the main system en masse.
It's very obvious why it works like an antenna. It is unlikely that it should not
> I think Uber drivers/couriers are freelancers

yep so they should be compensated more, not less, in sight of the precarity of their job

> When you factor in that many (probably most) Uber drivers are only working part-time, that's significant income from a super flexible job

super flexible for whom? the drivers? or for Uber?

There are two sides to the gig style work, one side is a corp that's got teams of PhDs and a cloud calculating its optimal risk-reward strategy, and the other side some poor people trying to make money. How this can possibly turn out well for the latter is a pipe dream.
With unemployment this low there are plenty of entry level jobs people can get into in every city in the country. I live in Seattle and I see people out begging to give people entry level/beginner jobs by the light rail stations and all around the city, but homelessness is still on the rise. Bussing them elsewhere doesn't help when they still don't have a home, a bathroom/shower, clean clothes, food, etc.

Bussing them out is just an idea done by the rich so they don't have to see the homeless any longer.
In fairness, we produce monoclonal abs for new indications - and get them into production - constantly. It's one of the richest fields in pharma right now. And people have been having slow-moving but noticeable success with this sort of approach for flu for a few years now. We may get there.

And when we do, it won't be recognizably related to this article, because the pop-sci writer and his headline editor mangled the description so terribly that it bears only a passing resemblance to what the study actually did.
It's not widely perceived as a Chess metaphor anymore; like David S. Pumpkins, it's its own thing.
Of course, this is the obvious answer. Just curious to see if anyone had any interesting, novel thoughts on the idea.
I imagine that that simply reinforces how one is old and not new in contrast with the additional person.
What about a hardware switch? You know, a mechanical switch, like the one already used to detect whether the lid is closed? Besides, I also want the mic disabled when my laptop is open...
Yes you're probably right. I haven't dug much into it myself
> we also know that exposure to strong(er) magnetic fields like from MRI machines can disrupt pregnancy

No. The American College of Radiology contradicts this: "Present data have not conclusively documented any
deleterious effects of MR imaging exposure on the
developing fetus. Therefore no special consideration is
recommended for the first, versus any other, trimester
in pregnancy."

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmri.24011
Doesn’t that get incredibly complicated when dealing with non-binary data? How many bytes would you have to read to determine an html file, a markdown file, an Apache config file, etc. etc.
Coca-Cola plays in different league than 99% of companies. Coca-Cola and McDonalds are ages-old established brands, a huge parts of western culture. They can't possibly get any more exposure than they already have. I do not know what is their exact strategy, but to me it seems more about maintaining constant level of presence in people's minds, so that everyone just remembers they're still there and still good.
I'm waiting for a paper to come out discussing the use of the accelerometer or gyroscope to record audio.
Report Developers, on the other hand, are folks who have made a career around designing reports in a specific tool (e.g. Microstrategy, et al). They are specialists.

Is this the common perception, because it really doesn't line up with my experience?
It is often the case under US law that failing to file paperwork is treated as a much less serious act than filing fraudulent paperwork. If you fail to file a tax return, you're nearly always assessed a penalty (it's a misdemeanor). If you file a fraudulent tax return, you can easily go to prison for a long time (it's a felony).
In the parlance of Domain-Driven Design, every aggregate (think object instance as a loose equivalence) is its own stream of events. Loading aggregates involves replaying events until you are caught up.

The key design requirement here is to deeply understand the reads your application will need to perform.

The downsides are you have to push the data somewhere else to digest and report on it. Relations are tough to model, too, as events that happen to more than one aggregate essentially have to repeat the data in each stream in the form appropriate to that domain entity. (You can often model this as one event causing another. Projections work less well for this circumstance.)

This can make it hard to draw data from the underlying store. Instead you must "hydrate" it into objects in memory to ask questions of it, though projections can help. EventStore is definitely not the right choice if you need ad hoc query capability. (I used EventStore in production for 2 years with F#.)

I'd classify this as an exotic data store. Use it if you have a really strong need for event-sourcing. Me... I'd likely choose Datomic instead.
When this first came on, I thought: oh, did someone make a new documentary? It was full of nostalgic nice things that Mr. Rogers was known for. It brought back memories.

And then, it ended in the cheapest, most offensive, most un-Mister-Rogers way possible: just a Google ad. I refuse to even let myself recall what crappy product apparently demanded the outright abuse of a man’s lifetime of genuine contributions to society out of some sense of clever advertising.

This feels like a bunch of Google executives just took a can of spray paint to deface everything that Mr. Rogers ever did. And Google, you don’t understand anything about why Mr. Rogers was so great.
Yes, there are jobs in every city, but in major cities there is difficulty in finding housing and transportation. The cost of living is also high, so it's easy to get into debt. Whereas in smaller cities, it's typically easier to get on your feet because housing is more accessible, transportation is better, and the general CoL is a lot lower.
> you don't become the fastest growing company of all time by avoiding any toe-stepping

this is purified hubris, how can you not vomit on your keyboard while writing that?

> roughly 200 to 400 total bikes. It's really a pathetic number of bikes and doesn't come close to meeting demand

maybe the mandate of SF is not to satisfy demand or Uber's profit incentive but to keep public interest in mind, e.g. ensure that Uber doesn't develop a monopoly on whatever a jump bike is.
> Think asbestos and mesothelioma. The onset of that can be forty years after exposure to asbestos. That's roughly two generations. And a one off event can be enough.

Except that mesothelioma can onset at 15 years and is less rare at 25. And it is one of the longest because of the particular mechanism of encapsulation and migration. DNA disruption has no such reason to be slow.

There are almost always some people with a fast response to a biologically active agent. DNA damage would almost certainly show up quite quickly in some subgroup.

While you can't prove a negative, absence of evidence certainly moves the Bayesian priors.
Then the next question is whether it will work effectively in humans, with no cure-worse-than-the-disease side-effects.
Which is one of the reason I call most ads abuse (and got into a lengthy subthread because of that recently). If a product is not compelling enough on its own to occupy brain space, what entitles the seller to perform emotional trickery to gain the place in people's minds they're not supposed to?
Oops, indeed. Didn’t realize that Clojure flatten is recursive.
I actually posted the protocol spec somewhere a few months ago, but it might have gotten taken down when I flipped the beta site into the production site.

Mim (comes from 'mime' from 'to replicate') is a HTTP based stateless protocol where the nodes communicate with each other via bog-standard HTTP GET and POST requests. The nodes can create caches for oft-requested data. c0 is a subprotocol of Mim that defines six graph objects, boards, threads, posts, userkeys, votes and truststates. the first four are obvious, the vote is a userkey > b|t|p relation, a trustste is a userkey > userkey relation. It creates a directed graph that is mostly acyclic.

It allows for efficient flood-network propagation of this graph based on time intervals, and it comes with certain patch semantics, so given a delta communicated from one node to another, there is always a way to apply that delta into the local node's graph in a way that does not create merge conflicts.
I am assuming that if the T2 chip is unlocked (the laptop is in use) then the microphone is still available.

If not, then you’re right it would be exactly the same.
This seems craaaazy complicated. In C++, I'm only familiar with the abseil libraries for thread safety, but the way to make sure multiple threads don't access shared state is:

absl::MutexLock l(&mutex_);
// Critical section.

The idea that you have to write a "waiting queue" every time you need to guard shared state in Swift is mind boggling. Surely not!
My prediction for 2019: Microsoft announces Microsoft Linux, with many Microsoft store apps working via a compatibility layer. Office for Linux coming early 2021.
This sounds relatively simple to test.

Get a laptop, write a script to randomly enable/disable wi-fi every $timeinterval (and log whether or not it was enabled). (Also need to block the taskbar icon, somehow... can probably just hide it.)

If 10 minutes of Wi-Fi being on is enough to cause noticeable symptoms, it should be quite easy to prove that - if you can successfully determine whether or not Wi-Fi is on, better than chance, you have one heck of a significant result! You could save lots of people, most likely, from nasty symptoms

And if not... well, you have options there too.

(Of course, you have to make sure you get enough trials- and fix it ahead of time, can't just stop when you see a significant result!)
Honestly, Evernote does the vast majority of what you just listed. I’d highly recommended it giving it a try if you haven’t already.
9 software project management tips for agencies
> It is only once you succeed that people are quick to call you [smart, creative, etc] before going back to enforcing the same rules you barely survived.

This very eloquently sums up most of my experience with society. If you succeed, it's 100% because of talent or privilige or dumb luck or not having to work a part-time job to feed yourself/your younger siblings/your ravenous creditors, and 0% because of any actual effort on your part. If you fail, it's clearly because you're a lazy good-for-nothing welfare-sucking leech, and any attempt to point out other reasons is just excuse-making.

"If we succeed, no one will remember. If we fail, no one will forget."

(Incidentally, while trying to find the source for the above, I discovered that Google considers it a "inspirational quot[e] about overcoming failure".)
Jeri likely would find a way to defeat the robots by building a machine gun that shoots pinballs and is controlled by a brainwave interface to a SID chip.
My main issue with seattle is that, although the rent problem is not nearly as bad as SF, they have been ramping up their own spending exponentially. So what the landlord is not getting, the public officials are spending.