Your comments really spoke to me. While I can't say that all the topics you noted impact me to the same degree, there are certainly similarities in how I also feel about some of them. Perhaps my following plan of what I'm doing might help you, or give you some mild inspiration/ideas...

1. Lessen overall life expenses.

Why? Not so much to be financially independent/retire early (I think they call this "FiRE")...though that would be great...It is more about giving myself even more leverage in job searches and salary negotiations. If my expenses are lower, then getting a job with a non-profit/NGO whose mission i might believe allows me to think less about likely getting a lower-than-industry-standard salary.

2. Focus on a side hustle.

Now, this could be a side business, which - if successful - further detaches you from being beholden to a corporate entity...Or, it could simply be volunteering for a local cause that you believe in, or even civic engagement more with your local community (e.g. getting involved in local town/citizen meetings), etc. The trick here is that you have to keep levels manageable. You want this side hustle specifically for the purposes to only slightly distract you from any depressive feelings you gain from your dayjob. If this side hustle grows too cumbersome, the fear is that this could of course lead you to burnout, which could lead to more triggers for feelings of depression. Use this as a distraction BUT more so for seeking areas of inspiration. (Caveat: I am NOT a mental health professional/doctor.)

3. Make a plan for where you want to see yourself in 10 years.

Normally, people put the plan first...but here I'm putting as step #3. Honestly, this step does not have to await conclusion of the above steps...you merely have to at least be well underway on both steps. This is purposeful. Sometimes people really don't know what they want to do for their rest of their lives, or at least in the next few years. By preparing you - making you financially flexible (due to having such low expenses vs. your current salary), and pumping your energy levels up (via either side hustle or volunteering/civic activity - first, it sort puts you through mental basic training. Then after you are deep into the first 2 steps, begin to formalize a plan for your life, or better yet, a plan for the next 10 years of your life.

4. Execute on the plan.

At some point - most likely - you will stumble upon something that gives you fulfillment. It might be wanting to create a non-profit startup, or maybe you will decide to be a community organizer (not as a volunteer, but as your full-time profession), or maybe you will create your own for-profit company, but you will run it in a way that you feel good about/fulfills you. Whatever it is, execute on your plan; 'nuff said.

I have no idea if the above proposal will work for you; YMMV. (I myself am not even all the way through it yet!) I also will clearly state that i am NOT a life coach nor a mental health professional, nor a doctor...I'm basically just a human being posting a comment on hacker news...So, from one stranger to another, I surely hope my comments help, and I really hope that you find what fulfills you.