skysight-inc/HackerNews huggingface dataset:
This is an interesting definition of marginal significance, with P=0.12 (more than double the standard 0.05) and 10%+ OR overlap.

You seem to be focusing on OR means too much.
Absolute risk adjustments are surprisingly low considering certain predictions.

I agree with the conclusion that 106 mg/dL mean could've reduced the power of the experiment.

I also agree that a good followup is relevant and important. It could change results a lot, including the initial positive results. However, in the meantime, we have no way to actually evaluate the risks and are essentially making educated guesses.
Note that the patients treated were on average 60 years old. This reduces followup time considerably but also reduces potential effect size.

The results are mostly based on ODYSSEY LONG TERM and FOURIER trials. The former verified PCSK9i alongside high dose statin therapy. The latter used a monotherapy in some cases but not defined the subgroup.

FOURIER alone is quite damning. ODYSSEY LONG TERM does not consider mortality endpoints.
Such interesting tidbits like "In terms of individual outcomes, evolocumab had no observed effect on cardiovascular mortality, and hence P values for other outcomes should be considered exploratory."

The inhibitors in question were allegedly not mainly tested here as an adjunct to statin therapy or replacement for resistant cases, but it so happened anyway.

You're supposed to be comparing it to current best known treatment which is statins, which is a very valid comparison. Any other comparison would only be of educational value but should be done regardless. It is even more suspect that it was not done but instead it was used as an adjunct. Not even canadian cross design was used...
It seems a lot of posters aren't willing to consider self-driving cars feasible until the cars are as foolhardy as the bottom-decile driver while still maintaining a perfect safety record. But most of accident prevention is in the planning more than the execution. It seems only reasonable to expect SDCs to avoid situations that some human drivers would brave if the risk is too high.
I've been biking in Oakland for over 10 years and have never gotten a death threat.
This is an awesome way to quantify the happiness you feel as a order of time. I wish I did this on a daily basis so that I could see the things that contribute and take away from my personal happiness. I tend to be a pretty introspective guy so I think about this kind of stuff on a regular basis, but I'd be curious to see if analyzing when I'm working out, vs playing videogames has an affect on my real happiness VS the blah feeling that you get when you are able to turn your brain off for a bit.

Kudos on this, and I assume there's a link to how you track your happiness in there somewhere. I've got to dive deeper.
I love reading about anything related to Hawaii.

Any HN'ers who live there? What's it like for [remote] tech work?
I agree with this sentiment 100%. I can use traditional search engines for "how to ping a rest thing in python", but I can't grep Github for even basic snippets of code. I don't think their global code search has ever been useful. Glad they have their priorities straight /s
Where was that? Numbers from one usual suspect:

> Our program requires no contribution from Harvard families with annual incomes below $65,000. About 20% of our families have no parent contribution.
> However, non-competes make prefect sense when a company is bought/sold. If I own a Marketing firm, and sell it to you, it would be perfectly reasonable, as part of that sale, for you to require me to sign a non-compete. Otherwise I could rent an office across town, call up all my old customers (the ones you just payed a lot of money to get) and convince them to switch to my new company and leave you high and dry.

Ironically, this happens fairly regularly. Companies will hire someone because of their "Rolodex", and the hope / belief / nudge wink that they will do exactly that, bring "their" customers to you.
> I've been using Lisp for more than 20 years and I don't agree. A repl is nice, and I use one often, but it does have tradeoffs.

Me neither, and I also carry decent Lisp cred.

I know what I'm doing to the extent that I can write a bunch of code in a file, and have it work, more or less.

If I experiment with changes to code, I want to see the diff (as in git diff).

Actually developing in a REPL seems very scatter-brained; you don't know what you're running since you've been mutating things left and right.

Those that develop in a REPL actually develop in some kind of text editor which sends expressions to the REPL; that's what allows them to save the code properly to a file. Problem is, you now have three versions of the code to keep straight: editor, file and image.

Okay, so you have massaged things into working. Well, which is the code that is working? Obviously, the code that is in the image. But of the textual codes does it correspond to? If you just save the content of every edit buffer to disk, is the code on disk exactly that code that is working in the image?

Even if I have to work with a running image (say there is a lot of state that is difficult to reproduce from a clean start), I'm still going to work with some files, which I will edit and completely save to disk, and load all together as a unit into the running image, instead of evaluating individual expressions out of an edit buffer.
Cloudbees Kubernetes Continuous Delivery
The people complaining about the GDPR have been complaining about the DMCA since before it was passed.
Stealing traffic also means stealing information about how many hits a page has if such is recorded via the webserver logs.

Honestly third party websites serving a proxy/cdn/transparent cache of a website is something that should require affirmative consent from either side of the party. Something Google is not getting, and as such stealing traffic is an acceptable critique.

It also reduces the security of the website by allowing users to get used to it being hosted from a google search page. SEO an imposter website that shows the same fake ui border and phish logins, the user wouldn't notice as it looks absolutely normal. (Something I might make a grey hat attempt at just because it's likely the only way to get google to stop doing it.)
The winner of the last Lisp Game Jam (https://technomancy.itch.io/exo-encounter-667) was written with it and love2d, seems pretty cool.
https://www.google.com/search?q=broken+iphone+cable&rlz=1C5C...

Stopping manual handling of the cable is urgent.
It’s irrelevant where it is said so long as it is said publicly.

Edit: This is the same reason Elon is now being sued for "Twibel". You cannot say state lies publicly without legal repercussions. "Funding secured" is classified as material non-public information.

I used to work in finance and regulatory compliance.
Those who do not understand Dijkstra are doomed to revinvent him.

There are plausible, though inferior, arguments for 1-based arrays. This person doesn't even manage to make them, though.
That's likely because the SEC does not have the power to undertake criminal prosecutions.
Never heard of this one, and didn't know anything about it. I tried reading the Wikipedia page. Now I've heard of it, but still don't know anything about it.
I provided my employment agreement to the new company when they asked for it.
1) some of these complaints are invalid: yes Linux kill a "random" process when there is no more memory available, but except in 'static' configuration where everything has a known size, what's the alternative?

You can have a misbehaving application use lots of memory but it's a normal application whose memory allocation fail, what do you do?

2) this bloat isn't new: I remember being amazed by BeOS responsiveness compared to Windows or Linux but now I spend 80% of my time in a webbrowser and I doubt WebKit is going to be faster on Haiku than it is on other OSs..
I think you're describing out situation pretty well, and as much as I hate it, I see the logic. That said: if we don't keep innovating, some newcomer is going to beat us up and steal our lunch money.
Syria Shoots Down Russian Military ELINT Plane During Israeli Airstrike
Endowments.

Like most top universities Rice has a large endowment. It's upwards of $5 billion in their case. If we take a sub market interest rate of 5% that's $250 million a year. Their entire undergrad body is 4k. That's $62,500 per student per year on a conservative return rate. No top universities actually need tuition anymore, but even top universities are increasingly being run as businesses with growth in 'revenue' seen as a positive in and of itself, necessity aside.

And in this case, they'll likely see major returns on it anyhow. Come donation time, I expect those graduates who were able to find a better place in life thanks to a voluntarily free education are going to be quite quick to open their wallets especially knowing that those donations will in turn go to productively helping the next generation of graduates going through the same cycle.
I'm right. From their own website:

https://financialaid.rice.edu/thericeinvestment
Is it some search algorithm that is so new, unusual and groundbreaking you can't talk about until it patented, or what?
I'm zoomed in at 200% on an 11" at 1366x768 and still all the text wraps cleanly within the viewport.

If I want to zoom in further I can click the little book icon for reader view in Firefox, and the content will wrap without scrollbars to my heart's content.

So again, evil in the same way a BDFL maintainer is a tyrant.
In these times of dynamic frequency scaling even the temperature of the room the computer is sitting in ia going to affect the performance.

In practice I think hard real-time systems use extremely conservative estimates of cpu performance.
You can definitely put ads without deep profiling. They can even be relevant. Just advertise for fishing accessories in fishing articles. Or hardware load balancers on Slashdot. Why not? Better than serving me whatever someone in my family has looked before (that is if I didn't have an adblocker for the past 10 tears)
I'm no expert on these matters, but it's the internet so I have an opinion. These territories face a catch-22: to the extent they raise taxes they become less attractive to the Super Rich (well outside investment in general). You might also end up with a race to the bottom scenario, where taxes go to zero, labor laws go to heck. You actually see all of these issues and more in practice so it is not just theoretical. It is a difficult quandary to escape from. You basically need an engine for real organic growth that doesn't rely on tax gimmicks. Finally, I think Puerto Rico itself also suffers from an artificial handicap with respect to the Jones Act.
Fortunately for him, he's an engineer with thumbs and a screen, not a lawyer. I don't think it's particularly likely that this goes nuclear on Musk or Tesla but it's definitely absurd, as you said.
But that's not a condition of employment, that's a deal you make as a business owner. As a condition of employment, it has no reason to exist other than as a tool for businesses to abuse workers.
You've confused me as well. An ISO is sort of definitionally not the merchant underwriter ("Independent Sales Organization"). Maybe you're saying some underwriters/processors who sell direct? What is an example of an ISO that is a PayFac? There aren't many players in the business so naming names might help the general understanding.
I’m not backing off my argument; I’m arguing from a stance of reasonableness rather than perfection. And while we can argue on exactly what defines “reasonableness”, I think it’s unambiguously clear that a large number of people do in fact need 50% of their traffic to come from a single peer and I think it shouldn’t be unreasonable to expect an ISPs to address that rather than throttling customers. I know plenty of people whose internet usage consists of email, Facebook and hours upon hours of streaming Netflix.
> A blockchain being the place where the act of bureaucracy ends up being stored changes nothing about that.

This is where a lot of blockchain concepts seem to break down. In most systems at some point you need to trust the data entered in by humans. But how can the members of the system be sure they can trust other members? Maybe certification or auditing by a trusted third-party? Oh, we're right back to where we started.
What an ironic comment in itself. Those phrases mean exactly the same thing, yet we are all familiar with the habit of the powerful of spinning atrocities with words.

I for one suggest "production assurance security forces" instead of "paramilitary death squads".
PipeGears is open for beta
>Under the current system, if the most meritorious student's family makes over $130K, he/she is saddled with debt...

I live in the Rice U neighborhood. (Museum District). I'm very familiar with Rice. Believe me, if your hypothetical student really were the "most meritorious" student at Rice University, she would already have a full ride scholarship.

And if your "most meritorious" student at Rice University does NOT have a full ride scholarship, then she is not the "most meritorious" student at Rice.

The types of financial programs in question are for students who are qualified enough to get into Rice, but whose families are not well resourced enough to pay for Rice. These sorts of programs are laudable, and they are exactly what we need to be doing. There are "country bumpkins" from Angleton and Nacogdoches who are as ready to enter Rice as the sheltered kids behind the gates down Sunset in Houston. It's a GOOD thing that Rice is affording those less privileged children that opportunity.
This is the kind of thing that people mean by "disaster capitalism". PR is wrecked and desperate for money, so it resorts to tax competition - but only for wealthy foreigners, not its own residents. This drives up local inequality while also taking away from the mainland's tax base. And in the end it doesn't quite manage to solve the problems for the rest of PR.
The compiler can only help so much as many of the timing parameters are variables and runtime dependent.
That or "Absenteeism in democracies is (among others) increased by the fact that those with money have objectively more power, in turn leading to more absenteeism"

IOW: there is no clear cause and effect
I'm guessing there is a HUGE difference between, say, Twitter, and a regulatory filing.
Yes they did.

PIF, the sovereign fund, stated that they had no intention to go beyond their initial 5% investment.

Last week they invested $1b in a Tesla rival, Lucid.
The Calf Path
In my experience, hobbyists always use "hand soldering" to mean using a soldering iron, which is how I was using the term.
https://www.nytimes.com/2018/07/20/business/wework-vegetaria...

Wow. I am speechless. I am without speech.
Thank you for the thorough advice! Thing is, I'm interested in so many areas of computer science from low level compiler stuff all the way to machine learning. Hopefully from taking classes, I'll be able to narrow these downs.
There are ads on the front page designed to look like content.
Grew up in Hawaii, had no idea the word was trendy and don't think I've heard it since grade school. Really weird to me.
Seems similar to Setka Editor (https://setka.io/) .
XpressWest has secured most of the state and federal approvals needed to develop a 185-mile route for electric trains to travel at speeds up to 150 miles an hour between Las Vegas and Victorville, Calif., a high-desert city on the outskirts of the Los Angeles metro area.

Getting to Victorville is one thing. But until someone figures out how to traverse Cajon Pass† in a high speed train, it's just not going to work.

Even at 150MPH, the journey will take longer than a plane. And why would I want to change trains between Los Angeles and Las Vegas, when I can fly direct in an hour? Las Vegas is compact enough that the traditional train advantage of terminating at the city center doesn't help, since that's where the airport is, too.

Until the train is one hop from Vegas to downtown LA, it's DOA.

†https://en.wikipedia.org/wiki/Cajon_Pass
Besides access to education, is there much that can lift the quality of life for generations than meaningfully transferable education to a career path.

Having access to meaningful, transferable and applicable education (one that can be equally applied without a huge saddle of student debt) is a life changer, less so for those who already enjoy privilege and access to opportunity.
No, that's asinine and not better at all since it doesn't address the problem.
...could not bear the whole-room-illuminating glare of the bright green/blue LED and do not recommend it.

I had the same problem, although the charger was black so I used a small strip of electrical tape. Didn't cost me a thing.
The Guardian article quoted here is a bit more substantive (https://www.theguardian.com/books/2018/sep/15/french-booksho...).

Basic story is: Author (https://fr.wikipedia.org/wiki/Marco_Koskas, no English wikipedia page) who had other books published, could not find a publisher for his latest book, so self publishes it on Amazon's Createspace. So, this is not a book published by Amazon, which I first thought was the case.

Is this any different from, say, giving an Oscar to a movie that Netflix produced and only available (at least initially) through it? See here for a discussion on precisely this question: https://www.vanityfair.com/hollywood/2017/11/netflix-the-osc...

Amazon is stamping out bookstores, so fighting against that, I think, is perfectly OK; however, pushing back against original content just because it came from Amazon sounds absurd or protectionist.
for the same number of employees and the same cost - building bigger office with bare-minimum satisfactory tolerances vs. smaller office with unnecessary high tolerances. Saving at one place to spend at another.
The 3 kinds of non fiction books
I agree; the specifics never matter as much as the core principles of how something actually works. Thanks so much!
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It's easy -- just use variable position wireless power transmitted through multiple cooperative flux generators!

I'd submitted https://news.ycombinator.com/item?id=17980168 a few days ago, links to a landing page for a white paper and presentation.

Direct link: https://www.wirelesspowerconsortium.com/technology/multiple-...
There’s no requirement that he lie that way in a regulatory filing, previous posters are trying to explain to you that it’s enough to make the claim publically. Lying in a filing would be a different crime.
If you mean "blockchain technology" to mean cryptographic ledgers than yes.

If you mean blockchain technology as defined by the original bitcoin paper, then why? What use does the system gain by allowing anyone to participate anonymously (e.g. money).

Blockchains solve specific problems. Cryptographic ledgers, like we already use for things like CAs, are the better choice almost always. Certainly they could be made more like blockchains in their openness, transparency, and participation. But going full blockchain isn't required.

However some people have been using "blockchain technology" to include the ideas of cryptographic ledgers, so I want to be clear.
The IPO process is very tricky too; they want large holders to keep their stock as long as possible either to avoid tanking it or to keep the float small so it will bid up quickly. Naturally all these people can get out before the employee lockup ends though.
Kind of true of all [new] technology though. Will it be a Betamax or a Blu Ray? I think the point of the article is trying to make the case that maybe you don't need the extra complexity of ActivityPub for your project.

Also, that user was completely right re: Dropbox, but they missed the market value of packaging all that for you in a few clicks install, on any platform with 99% uptime (also, I believe that user has noted in other threads they recognize their mistake in making the argument that Dropbox wasn't a value-add). On the other hand, it seems to my uneducated opinion on ActivityPub, that it is trading extra complexity for...push?
>But privately owned gasoline-guzzlers are an archaic solution to the transportation problem

Private vehicle ownership isn’t about solving society’s transportation issue. As far as consumers are concerned, a car is one of the most significant and life changing purchases they’ll ever make. It gives them far more than just a solution to a ‘transport problem’, it provides the freedom to pretty much go anywhere and do anything at any time. If your idea is ‘convince people they don’t actually want cars’, then your idea is going to fail.
Started with message boards (the physical kind!), went from small/private jobs to b2b jobs by using the small/private people's references to get in to their employers and business networks (the people network kind).

In the space of about 6 months went from 100% private jobs to 50% private, 25% small business and 25% medium business.

As much as people seem to be busy with their CV and references, it's often more the presentation of your skills in-situ and the impression you make on potential sources of jobs that will get you a constant flow. In the space of about 18 months I was booked about half a year in advance. This is in a western european country with about 17 million people to give you some context.

About said context: it really depends on your location, rules, lawyerisms and style of capitalism.
Ask HN: Is mobile network (radio) regulation technologically necessary?
Hello,

I'd like to ask experts on the topic of mobile networks. Why is it necessary to regulate the frequencies? Why can WiFi function sufficiently well without regulation? What are the differences? If we had a clean slate (we could replace everything - consumer devices as well as infrastructure), would it be possible to design mobile network that shares the characteristics of WiFi (everyone can setup one) and LTE (speed - let's say that 16 Mb/s is enough, seamless roaming between nodes)?

Thank you!
Tesla regulatory filings mention to his twitter account as an official source of news.
#NSO mobile #Pegasus #Spyware used in operations in 45 countries
They have scaled their manufacturing quite well be now. They are not top of the line but the have a real mass production car.

Have you actually looked at the production numbers of those other EVs? Because there is nobody outside of Tesla that has mass produced EV and even more imprtantly, to do it with profit mergin per car.

Teslas are the Top 3 most sold EVs in the US market. The model 3 is by now equaling the sum of all other EVs and is almost 100% of the growth in EVs.

Futhermore, the iPace, i3, Tycan and many others saw production delays as well. So the idea that you can let some established company do it and they will do way better then Tesla has jet to be shown.to be true.

The original Tesla Killer, the Bolt, is outsold by Tesla 15 to 1.

Competitors have announced many EVs but most will hit the market around 2020 and most of them will not produce near as many as the Model 3.
Thank you so much for this! I'm a mid-level Japanese language student and have been looking for something exactly like this for a long time.
You were uncivil and you insinuated that other users were astroturfing. That's two guidelines right there. Also, we've had to warn you before.

(Mods can't downvote replies to themselves, same as other users.)
Yes, you're right – thanks!
The article mentions that parts of the island haven't been reassessed for property taxes in 60 years.
The user I replied to has cookies disabled anyway, so that should not be an issue in this case.
Same things for most cities in France