skysight-inc/HackerNews huggingface dataset:
Thanks, I actually hadn't seen that. The data I was referring to is from my own analysis of 2017 new drug approvals on FDA's website

That paper covers 1998 to 2010, roughly coinciding with the end of the booming era of cardiovascular and psychiatric small molecules (prozac, lipitor etc) and ending right before the patent cliff in 2012, which saw the pharma industry's revenue shrink for the first time ever

Since then, R&D has shifted strongly to smaller companies from big ones, as the data reflects.
Making C less dangerous [pdf]
Neat! That's definitely better than some of the other shell clones I've seen, in that it makes an attempt to filter out files based on .gitignore. But it looks like it still gets some .gitignore stuff wrong. It's hard to handle .gitignore correctly in a simple way.

In some simple tests on my Linux checkout, it is about an order of magnitude slower than ripgrep though. It looks like a good chunk of time is spent in gitignore filtering?

I don't think it has multi-line search, which is something I've learned that ag users happen to love, which is why it's in the most recent release of ripgrep. :-)
I'm not following how authentication obviates the need for record-keeping.

Credit reporting agencies are basically a data warehouse for financial event history. If such a thing didn't exist in some form, how would a lender check whether you made previous payments on time? They can't contact every possible creditor that you could have interacted with.

Maybe a better architecture is possible than storing all the data centrally and creating a massive single point of failure, though.
The Death Guard by Chadwick -- fleshy robot armies

https://www.amazon.co.uk/Death-Guard-Roc-S/dp/014017060X

Stand on Zanzibar by Brunner -- notable for hip-crime vocab

https://en.wikipedia.org/wiki/Stand_on_Zanzibar
>They have faster-than-light space travel, but image manipulation is unthinkable.

See "The Road Not Taken" by Harry Turtledove, where the idea is that humans developed advanced technology only because they failed to figure out the trick for easy FTL travel.
As many people have pointed out, what you have said is untrue. I'd actually read about the regulation before commenting on its sanity.
Honestly, I wouldn't be asking Hacker News, I don't think anyone here knows what would be best for you.

As someone else mentioned, you can often take 3 months unpaid leave. Often you can do something like take your 3 weeks vacation + 9 weeks of unpaid leave. This is pretty much true with any company I know of in the U.S. and / or Europe (so long as you are not a contractor).
http://www.tylerlhobbs.com <— some really good generative pieces on here
The first image is really cool, would be great if you could share your code or just the idea behind it!
I'm assuming he means people who are caught with opioids who are not necessarily addicted to them.
I prefer this classic demo from 1965: https://www.youtube.com/watch?v=HdkixaxjZCM
Oh that's very interesting, thank you! Do you know if Nix works well with Ubuntu? I'd love to use it but I didn't think it would play well with apt.
What a great (and overwhelming) list!

In the code hosting section keybase seems to be missing. It has git support.
Index 1,600M Keys with Automata and Rust
Stack Exchange Site Performance Statistics
I tried this the other day because Google Stackdriver claims to need third-party cookies enabled, which is an absolute no-go, but it also refuses to work in incognito mode and even the container mode didn't help, IIRC.
Welcome to capitalism & competitive forces 101.

Of course the hot money moves to the place offering optimal conditions. Just like if you have a very portable app you'll host it on whatever cloud provider is cheapest & best.
You are missing out on the additional information about you that they got when you added your partner, i.e. that you are in a long-term relationship. Married men are well-known to be lower-risk drivers than single men, presumably the insurer also knows that men in a relationship significant enough to buy insurance together are also lower risk.

Also, someone who hardly ever drives is very safe from the insurer's perspective. They may not be very skilled, but they also don't have many opportunities to get in accidents.
There are some errors here:

> The dramatic shift to SUVs in the U.S. is driven by consumers caring less about traditional car value metrics such as performance.

The cause of this was exactly the opposite -- the CAFE rules classify SUVs as trucks and allow them to fall into a less stringent fuel economy standard. The result allows SUVs to be mass-market gasoline-powered large vehicles with powerful engines, which is no longer possible for things classified as cars. That factor is primarily what caused (big-engined) SUVs to replace station wagons and large performace sedans in the market, and the small car market is as strong as it ever was.

He also calls Ives a visionary more than once, but that was Jobs. Apple has done well under Ives because of his management ability, not his ability to develop new product markets as Jobs did.

Project Titan is a huge gamble. They're essentially trying to buy their way into a market where their competitors have a head start. Apple has the cash to potentially succeed doing that, but they could also spend billions and have it come to nothing, and it's not clear what they're adding that Waymo or Telsa or Uber doesn't already have. It seems to be some combination of "Google is doing it" and the fact that Steve Jobs saw that Telsa was onto something -- but there has been ten years of progress between then and now.

And the speculation that Apple will focus on personalization is odd. Their model is walled-garden, curation, single USB port on the MacBook, everything soldered and nothing modular, any color you want as long as it's black. If anything vehicle personalization is going to become less prevalant with autonomous vehicles as it makes it easier to share vehicles if they can show up at the location of whichever part-owner needs it at a given time, or be leased out for ride sharing when not in use.
All books from Basecamp founders. Especially the first one - Getting Real.

I preordered their latest book 'It Doesn't Have to Be Crazy at Work'.

A lot of their advice is aimed towards small teams. And often contrary to SV wisdom. We've built a few profitable businesses by following their advice without raising any funding.
XSV: A fast CSV command-line toolkit written in Rust
No one is forcing you to go full ray trace for real time. It's not even attainable yet. Hybrid solutions are where we'll be soon enough with RTX (and hopefully similar by others). Considering hybrid pipeline, of course you would need a fallback for most stuff. That's what you do now with modern features in APIs/cards now as well.

Thing with raytracing though is, if anything, complexity is highly reduced compared to rasterization. That's kind of the whole point of it. With it (rt) you trade less complexity and elegance with more computing power needed.
One of the keys here that a lot of people miss is that mm-wave alone will not fill the BB need. It is the combination of sub-6ghz and mm-wave. 5Gnr works in high band, mm-wave and low/mid-band. This is the key, using each in the appropriate situation. mm-wave in dense urban, fiber rich areas, sub-6 in more rural and xburbs.
I like the bookmarks, that I was able to customise it extensively, the sidebar is very useful and unobtrusive. I do like also that is based on chromium. All in all I feel like it has everything that other browsers have and just a bit more or a bit better.
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This is cool. After skimming a few profiles of folks I know and read mood detection is questionable but the "Topics of interest" is spot on.
> For example, consider a finite number of legos in a room.

This works with legos, but not subatomic particles. No matter how smart you are, you can't distinguish between two states which differ only by having two electrons swapped.
Definitely they hold value stronger in the open market. At auction they do pretty bad (or did, at least, as of perhaps six months ago). Other EVs do worse. The 500E tends to go through auction at three years for about $4500, though it goes for almost twice that on the open market.
I'll draw heat for this but I think most business books are boring and/or suffer from survivorship bias.

The most interesting business book I've ever read was Creativity Inc, by Ed Catmull. He talks in depth about managing a business where creativity is the most important aspect.

The Start-up manual is good too, if a little drawn out.
> When conflict arises, restorative approaches are more effective than punitive approaches. Restorative approaches look at what happened, why it happened, what harm was caused, and what can be done to address the actual harm that was caused. Restorative approaches are not weak if they are done well.

The best “restorative approaches” engage the students in solving the problem (often teachers don’t even need to make a decision, the students can work out something more effective and satisfactory for themselves), whereas “punitive approaches” just add conflict and amplify problems and students reject the imposition on their autonomy.
Creativity Inc., by Pixar co-founder Ed Catmull. A funny and insightful book that should be required reading for any technical leader who works with artists/designers.

http://www.creativityincbook.com
> is it known to be a community

indeed, also look up "new media art". Also, obligatory https://www.openprocessing.org/

... and obligatory self-promotion - I work in the field on a sequencer for creative coding : https://ossia.io
Note that Noether's second theorem still applies, so any timelike vector field will yield a conservation law due to diffeomorphism invariance. In that sense, energy conservation still holds even in the absence of Killing fields, though some people argue this doesn't count as a 'proper' law of energy conservation as it includes contributions by the gravitational field, for which an energy-momentum tensor cannot be defined...
I've only read one business book, and that was it.

Kidding aside, I think it's a good one because it's a mix of analysis and history. Thiel had a unique vantage point, and he shares it well.

It also challenges you to be ambitious, which is becoming a rare sentiment.
They lost me at " replacing pre-installed BSD programs..."
I second this. In my opinion, it's the best book ever written on relationships, business, leadership, friendship, politics and more.

That being said, a lot of people read it as a way to manipulate people. It shouldn't be read that way. Rather, if you follow the advice, it has to be genuine.
Machine gun kelly- rap devil but every insult = 1000% Faster
Yeah, this was just a 1 afternoon project, and the .gitignore syntax is more complicated than I first thought.
Stapledon's Sirius, the awakening of a pet dog retrofitted with emerging sentience completely freaked me out when I was tween - brilliant stuff - relevant to the AI debate, but a new angle: enhanced animal minds !

https://en.wikipedia.org/wiki/Sirius_(novel)
>I think I'd like a better definition of "small town". At least where I live there are a LOT of suburbs which are sort of their own towns, but they're not really self-sufficient

This is a problem plaguing almost all comparative writing about cities and why the OMB defines MSAs and CSAs for performing meaningful like-like comparisons. (It's also for this reason that most ranked city lists are useless garbage built on the false premise that political borders are a good way to delineate towns for anything beyond politics.)
Ha, that's neet. I particularly like the "Probable Mood" addition.
Jack Donaghy: Imagine that your favorite corn chip manufacturer also owned the number one diarrhea medication.

Liz Lemon: That'd be great, 'cause then they could put a little sample of the medicine in each bag.

Jack Donaghy: Keep thinking.

Liz Lemon: [beat] Except then they might be tempted to make the corn chips give you...

Jack Donaghy: Vertical integration.
I think the parent meant that the visitors think that a photograph can't be manipulated and is thus a perfect record. Today of course editing photos is commonplace.
> Even acquisitions that included consumer-facing products like Beats, Beddit, and Shazam (pending approval) were ultimately about the technology behind the products.

I doubt the Beats acquisition is about the technology behind their headphones, especially with their questionable acoustics engineering [1]. The music service sounds more plausible, but then it wouldn't be about technology either.

[1]: https://www.designnews.com/gadget-freak/beats-dre-teardown-w...
Look into some of Picasso’s earlier art, and his later art makes more sense. You can find drawing he did as a teenager which are fantastically perfect drawings. Seeing that made me understand him better—he didn’t want to be stuck in a tradition that he mastered as a child.
Thank you for this. I've been programming for a while and always appreciate another perspective on things. Starting with 3 now!
Yeah, you may also find interaction free measurements interesting (https://en.wikipedia.org/wiki/Interaction-free_measurement).
Really?

Maybe this is just me, but I read science fiction specifically because its one of the few genres (when written well, as opposed to the "sturgeons-law" filler based on "tech/fantasy gimmick of the week") that expands themes and ideas above and beyond the themes, ideas and perspectives available in "everyday" literature.

Even in your example, i'm not sure what it is that is laughable or anachronistic.

Perhaps this is just me coming at it from the anthropology/sociological perspective, but since i find so much about our current society and beliefs (including perspectives, beliefs and behaviours of those in the tech sector and those talking about tech) as so comically insane, reading about these alternative technological visions seems like passing the lowest barrier of "suspension of disbelief" necessary.

And since its science-fiction, that's a barrier I thought most people would have passed by the time they've decided they're going to pick up a science-fiction book...

"I read books about (maybe even believe in) strong-AI, but reading a book where a hologram tells humans they can smoke or drink (given that humans are illogical creatures often needing to be pointed out simple logical inductions and that they CURRENTLY smoke and take drugs and have done so for most of human history) is just so laughably anachronistic!"

But you know, I like things like "I, Pencil" so breathless descriptions of automatic train ticket kiosks might just be my thing.
I'm sorry that I raised your blood pressure, and I take your point that I could have worded it better. I (admittedly quite poorly) attempted to push OP to get more specific. That was my only intention.

I completely agree about the dark pattern and I think that's a really good point that I didn't consider at all in what I said.

However, my argument regarding Chrome is that Google carries out tracking so pervasive that it basically doesn't matter any more if they throw a dark pattern like this in the mix. I am still trying to come to terms with how banal this evil has become.
If you just need an adventure for a year a two I'd say go for it!
BUT, as an expat living in the Netherlands I mostly see people from south Europe immigrating north (to Germany, Netherlands and probably Scandinavia as well). I don't hear many stories of people immigrating south (other than retirees maybe).
Spain has the weather going for it, other than that I can't think of any measurement of quality of life where it performs better than Sweden (perhaps besides life expectancy).
Who knows maybe you will fall in love with the culture and the weather, but you are coming from one of the highest ranking countries in quality of life.
Also, I hope it's obvious to you that going on a trip and living in a place or 2 different things.
Why? It’s easy to understand, and easy to appreciate. I agree that there’s not much content, but that also means there’s not much commitment to seeing it and enjoying it.
Where does an instance of a come from in that case? A function of that type has no way to construct one.
It also drastically decreases the likelyhood of potential harm from the government's use of violence in it's drug war. This is not an insignificant part of the danger of opioid use.
Not that it matters too much but IIRC they said you had until the 2nd to pay and the eviction notice was on the door at something like 4pm on the 2nd when I came home. I thought it was absurdly early and went and paid but didn't realize they went to all the trouble of filing with the courts until I was looking for an apartment a year or so later.

They were also kind of sketchy when I had to break my lease because my reserve unit got called up to active duty, apparently they were trying to say I had to keep paying until my mom (who was handling my finances while I was gone) threatened to get the army lawyers after them which made them change their tune real quick.
You’re right! I hadn’t known that buprenorphine also caused it, but it seems all of the drugs used for that purpose. I did find a 2013 study stating that the effect was significantly less than that from methadone, but it’s good to know that both come with cardiac risks.
Thanks. I would credit "acquired after NDA was already filed" new drugs to small companies even if they were owned by big companies at time of approval. Either way, if 12 out of 21 small-company drugs were developed all the way to the way to approval without bigger companies, my earlier guess that the majority required big company help to finish was incorrect.
What gets me are the psychic powers -- Sci-Fi's weird obsession with mumbo-jumbo parapsychology such as ESP which ran I think roughly from 1955 to 1980. In the Foundation series it manifests as the mental powers of the Second Foundationers (their ability to directly seize control of other people's minds, above and beyond their mathematical skill and knowledge of 'psychohistory').
Even still, that was (looks like) assembly work -- they moved explicitly to be closer to the part suppliers.
Venture Capital Funnel Shows Odds of Becoming a Unicorn Are About 1%
I don't know that they ever flat-out phrased it as extremely as "impossible to get addicted to", but Purdue Pharma definitely made puffed-up claims that the extended-release nature of OxyContin drastically lowered addiction potential compared to immediate-release opioids. They were fined $600M for aggressively misleading marketing about its addiction potential and reduced side effects [1].

[1] https://www.nytimes.com/2007/05/10/business/11drug-web.html
Why? Many times I've encountered problems with BSD utilities in mac. Sometimes the options are under different switches, sometimes they simply don't exist.

I wouldn't use this script because I dislike installing so many packages that I don't need.
> Accordingly, some have concluded that Apple should acquire Tesla as a way of quickly jumping into the transportation industry.

I produce salty remarks. McDonald's produces salty food. Therefore McDonald's should buy me out as a way of quickly jumping into the HN snark industry.
It is not comparable oxycodone.

Oxycodone (present in oxycontin and percocet) is a full opioid agonist. Buprenorphine is a partial agonist and actually blocks most of subsequent opioid's effects.

The patent is still bullshit
> Dude, I don't know much, so I'm signposting the potentially incorrect assumptions I might be making, to help out whoever wants to answer my questions. You have a smug attitude, but I don't see you attempting an answer. What's up with that?

Okay, that's my fault. What you interpreted as smug should have come across as frustration. Most comments in this thread are evidently from people who didn't watch the video, threw in some assumptions, and declined to do a brief web search.

If you look elsewhere in the comments you'll see an earlier comment from me that likely fills in your gaps.

Can I suggest that rather than loading your questions like 'What happens when these fail- I assume they fail' you could ask 'How long will these last?'

Wikipedia's 'sand dam' article would answer that question. They're designed to go for 50+ years. (I expect they'd actually be serviceable a fair while longer.) In any case, you'd presumably be building others up or down stream.

Noting that the problem here is not what happens in 50 years (assuming what you're doing now doesn't jeopardise 2 gens forward) but rather what happens in the next few years -- specifically providing sustainable water, food, health, societal benefits to people who need those things now.

You suggested I was missing your point, but to be candid I wasn't sure what that was -- do you mean your criticism of the project because you didn't know if it was sustainable?

Sustainable farming is about a lot more than 'enough water in perpetuity' - it's about nutrient capture / cycles / management, resilience, minimising external inputs (f.e. pesticides, town water, fertilisers etc -- while insects, birds, dust, wind, rain, sun, nutrients from retrieved by grazing animals are usually considered freebies).

Note that most conventional / western / broad acre / industrial / monoculture farming by definition is not sustainable, regardless of water abundance.

It's fun to consider just how sustainable are the practices of generating the food you eat, especially in 'the west'.
Great list!
Dropbox Paper is missing in the notes section.
I second this. My favorite was Rework.
I'd agree. However, reading it is hard, really skim parts and come back to it over time. It's also where the Lean Startup started.
If it's a problem you should stop using both gmail and Chrome. Don't support companies that are anti-user.
> Perfect American English.

Maybe, that company has American expats living there otherwise it's natural to have some accent.
Reliable computer dictation is still science fiction.
You could use Missive to avoid this. It'd let you keep using your gmail account without having to ever log in to gmail in Chrome.
Not too bad and pretty clear description, actually:

linuxify_formulas=(
# GNU programs non-existing in macOS
"watch"
"wget"
"wdiff --with-gettext"
"gdb"

# GNU programs whose BSD counterpart is installed in macOS
"coreutils"
"binutils"
"diffutils"
"ed --with-default-names"
"findutils --with-default-names"
"gawk"
"gnu-indent --with-default-names"
"gnu-sed --with-default-names"
"gnu-tar --with-default-names"
"gnu-which --with-default-names"
"grep --with-default-names"
"gzip"
"screen"

# GNU programs existing in macOS which are outdated
"bash"
"emacs"
"gpatch"
"less"
"m4"
"make --with-default-names"
"nano"
"bison"

# BSD programs existing in macOS which are outdated
"flex"

# Other common/preferred programs in GNU/Linux distributions
"libressl"
"file-formula"
"git"
"openssh"
"perl"
"python"
"rsync"
"unzip"
"vim --override-system-vi"
)