skysight-inc/HackerNews huggingface dataset:
Methadone seems like a very dangerous drug to use outside of a controlled clinical setting. Terrifying that variance of dosage between users (~18x) is greater than theraputic index (12x) - meaning a dose that is ineffectively low for one person can be an overdose for a another.

"Methadone, an opioid analgesic, is used clinically in pain therapy as well as for substitution therapy in opioid addiction. It has a large interindividual variability in response and a narrow therapeutic index. Genetic polymorphisms in genes coding for methadone-metabolizing enzymes, transporter proteins (p-glycoprotein; P-gp), and mu-opioid receptors may explain part of the observed interindividual variation in the pharmacokinetics and pharmacodynamics of methadone. Cytochrome P450 (CYP) 3A4 and 2B6 have been identified as the main CYP isoforms involved in methadone metabolism. Methadone is a P-gp substrate, and, although there are inconsistent reports, ABCB1 genetic polymorphisms also contribute slightly to the interindividual variability of methadone kinetics and influence dose requirements. Genetic polymorphism is the cause of high interindividual variability of methadone blood concentrations for a given dose; for example, in order to obtain methadone plasma concentrations of 250 ng/mL, doses of racemic methadone as low as 55 mg/day or as high as 921 mg/day can be required in a 70-kg patient without any co-medication."

Li Y et al; Mol Diagn Ther 12 (2): 109-24 (2008)
Distributing Data Across Multiple Postgres Databases with Rails
IIRC they were owned by Match from the start.
"That’s why the world’s largest organization of computer scientists and engineers, the Association for Computing Machinery, of which I am president, has issued a new code of ethics for computing professionals. And it’s why ACM is taking other steps to help technologists engage with ethical questions."

I.e. "I wanted to be the president of some association, so I decided to bring political correctness to programming."

Hopefully this never catches on.
I suppose we are both confused then.

Politics is rooted solely in policy: if we do or don't form this or that policy, are the subjects of our policies better or worse off? Anything that distracts from a process of objective assessment and consensus-finding in the process of forming said policy means we fail to form the correct policies and so reflects an inefficiency.
I would love to see projects like MAME and MESS targeting FPGA hardware for near-perfect hardware emulation of classic hardware.
That's just the Eternal September.

Whilst I appreciate the OPs diligence, I would actually tend to disagree. The user may have seen it mentioned on indie hacker, which would be a plausible place to encounter 'a simple script that looked for available domains'
Already using the term 'Leftist' in such a broad and vague context makes it totally obvious that we see a tribal bad 'Leftist' vs. good conservative mindset here.
https://en.wikipedia.org/wiki/Hyperreality
Die off after aliens show up?

I guess it's possible, but that seems like an odd statement as they where doing alright until Europeans showed up.
It is more about the shift points in the transmission. Your engine is most efficient at around 90% throttle and "low" rpm. Your car is more fuel efficient are highway speeds then city street speeds (aerodynamic factors are insignificant at low speeds). The result is that engineers can trade acceleration for efficiency by changing the shift points, and you don't realize that the throttle is nearly wide open since the car isn't accelerating very hard at the low rpms.

Of course the engineers who design eco mode probably know more about how to do this than I do. I know they mess with shift points, it wouldn't surprise me if they did other things too.
The electric moped companies like Scoot are somehow getting around this. They must cap top speed at 20mph so that a license is not required.

They do recommend an in-person training course, but you can also simply watch a series of videos on their app, no special license required.
Yeah, it's kind of unreasonable to expect to get away with biking on a two lane highway with no shoulder, someone will get hurt doing that.
I don't know this specific API.

Either it works with web-hooks that you could lead to a Lambda via API-Gateway.

Or it needs to pull the data, then you could trigger Lambda via CloudWatch intervals.
I've never been more excited about a cloud platform than I am about Zeit/Now. I wish you offered stateful volumes or key value stores or something where I can persist my data so I can keep all of my stack on Zeit.
That page indicates that you do need an M1 for motor driven cycles(less than 150cc), and an M1 or M2 for Mopeds(which is news to me).
Fair criticism regarding anonymity. You can disregard my comments if that is an issue, but I would prefer to engage on this topic on equal footing and put aside any claimed background, if that works for you. Can you explain what it is that you think is invalid regarding money laundering with fraud as the underlying crime? Or, if another point I made was invalid, what that was?
> Wait for the snowplows, let the cars dry things out

This could take 2+ days, how will I get to work on those days?

> electrically heat everything on the scooter

So I basically need a car that isn't a car at this point, ok!

I'm not saying scooters aren't a viable business, they definitely are, and there are companies who make money selling scooters here in Canada. But they will never be more than a fun summer toy for the upper-middle class.
how is it a stretch? he's traded an ideological view for another?

I live in Austin, and I'm tired of hearing how traffic bad is from people who decided to buy a 3,500 sq foot home 40 miles outside of town and complain about "traffic" driving in.

we have a pretty messed up view of "owning" something without realizing that "owning" doesn't mean much other than "being owned by..." that big commute owns YOU
is it even possible to get a perceptible amount of nicotine through second hand smoke? isn't it mostly water vapor and annoying smells?
In UK a moped is 50 times more dangerous per unit of distance than a car. In EU 10 times:

https://ethicalhaydonism.wordpress.com/2018/02/04/micromorts...
If you want to share tools with your neighbor you have to know them and be on and maintain a good relationship with them. There are numerous downsides to borrowing and sharing, so much so that people would rather not do it. Nobody wants to pester their neighbor over and over to use some tool X. It's annoying for them and annoying for you. Ideally the tools would exist off both of your properties in some neutral place that either of you could just go and get the tools out of without pestering one another but for most people this just isn't practical. It's so much easier to just buy your own tools, or pay a contractor.
Ross doesn't deny sending the messages where he ordered the hit.

He has a marvelous, fantastic story for why he sent them, where he claims that he knew for a certainty that he was not actually ordering a 'real' hit, yet still wired hundreds of thousands of dollars worth of bitcoin to the assassin. It's about as plausible as 'This pound of cocaine, along with a stolen 9mm handgun fell from the sky, right into my person, your honor, I swear they aren't mine.'

There's possibility, with all the police misconduct, for him to claim something similar to the 'fruit of the poisoned tree', which might hypothetically. get the conviction thrown out. But its pretty much a certainty that he ran a drug marketplace, and tried to assassinate someone.
Doubt you would have this data but in case you do...

I wonder what the numbers are for people who read books to completion on ebook or paper formats. Or how far into the different formats people choose to read.

I know that most of the time when I read any ebooks, I end up never finishing the book. When it's paper, I usually finish the book.

I think it's mainly because with a paper book it's harder to get distracted than when I'm looking at ebooks. If it's a topic I'm studying, or need / really want to know then I'll get the paper version.
I don't think this is correct. According to that link:

A motor-driven cycle has 149cc or less engine size. CVC §405
A motor-driven cycle has to be registered and the driver must have a motorcycle license (M1).
> In GENERAL, it seems like it takes a lot more money and resources nowadays to do this, relative to other benefits you can have.

If you're talking about small ticket items, this seems true, but it certainly doesn't hold for more consequential expenditures like real estate or even cars.
The narrative is as what I have read from a book, wikipedia, and published articles from the 1960-1970s, where much of this theory also goes under first-wave, second-wave, third-wave, fourth-wave and post-feminism definitions. The history is not exactly defined in stone by any measure so it could be wrong.

When it comes to actually numbers I would like to think that most people would agree to view women and men as androgynous humans for all practical purposes unless it involves the sliver of domains where sex difference actually can be proven to have a large impact, and then being skeptical since most such finding that I have read get later reversed and attributed to culture and bias. I will assume you are one of those and thus give you an up vote.
Always interesting: Historical populations of Phoenix[0] and Tucson[0] – note the huge 1960s AC booms.

[0] https://en.wikipedia.org/wiki/Phoenix,_Arizona#Demographics
[1] https://en.wikipedia.org/wiki/Tucson,_Arizona#Demographics
The term "privilege" actually makes a lot of sense in the academic context, where it's been rigorously defined (both inclusively and exclusively), but as soon as it made its way into popular discourse, someone interpreted it as a thing that could be someone's "fault", and that narrative has never shaken loose.
> Silicon Valley has morphed and commercialized the term "sharing". You aren't "sharing" when you use Uber or AirBnB; you aren't pooling resources when you use Netflix or Amazon Books. You're renting. You're renting from a centralized company which outsources the generation of actual value to others, and pays them as little as possible. You aren't shifting your dependence from yourself to a community, but from yourself to a company that wants nothing more than to make money.

Amen. What grind my gears even more is when governments adopt that novspeak and promote the uberization of entire sectors under the guise of "sharing resources".
"cut that fridge up with a demolition saw to get it out of my house. This was satisfying."

So, Mr Customer, how do you really feel about our product?

Yeah, definitely satisfying. Well played.
You know, I think the thing that is interesting is Buffett never really was as resolute in Dodd's philosophy as many of the famous long/short investors who have struggled recently seem to be. Buffet evolved as an investor:

1. He recognized the multiplicative power of combining the insurance float alongside his stellar investment ability.

2. He recognized the power of moat and brand value vs. Graham and Doddsville.

3. He saw the value in return on capital over purely P/E for a growing business from Sees Candy.

As an aside, one reason long/shorts have had a tough time is that low rates make it harder to generate an automatic 6% return on your short book.

But, I believe many value investors have failed to understand how technology and network-based platforms work. P/S works better for AMZN than P/E when the CEO is trying to minimize E. NFLX could have lower its P/E to 20 if it charged $15/month last December. FB just had to monetize its platform by something like a couple dollars per user right after it IPO'd. I think many traditional value investors did not understand or adapt their thinking regarding stickiness, revenue per user expansion, fixed costs for platform-based businesses, and redefining what tangible and intangible asset value is.

There's an almost stubbornness to many of these investors versus a curiosity to listen to an alternative viewpoint.
It’s kind-of surprising to see “computer technical support” on the list of high-risk businesses.
Used ISDN and had the fax machine plugged into the encryption box and that into the ISDN wall socket.

Though no reason why such an approach could be utilised for pots based FAX machines.

As for the encryption - was pre-shared key type affair and unable to elaborate further.
It's at #110 for me now. There's a similarly-aged post with only a third of the votes that's on the front page at #16, though.
Never mind that AMD sockets used to last longer (less frequent incompatible socket changes), which meant you could do longer with your motherboard. Not sure if that still is the case though.
FlOpEDT: open source planning solution
Omnistereoscopic Video Pipeline for Capture and Display of Real-World VR [video]
Depends on what time-period you take as "modern". NYC circa 1920 had lots of tall buildings but no AC at all (I think, from memory). But absolutely was not possible without elevators. (And steel frames for buildings, too.)

But the article seems to take modern to mean present-day Houston, and Dubai, Singapore... these were not devoid of human settlement before, of course, but could not look as they do now without AC.
src: https://linuxfr.org/news/flopedt-un-nouveau-logiciel-libre-d...
Not enough people are paying attention to this economic trend
I agree, Rand's behavior was kind of accepted but its still not acceptable by society at large
While possible, my 3rd to 7th bullet points, a lack of any other activity from OP, and the instant downvote brigading still make me nearly certain that this was all a scheme to promote this one site.
Will this only work for Chileans? +1 for localization. I got confused with the amounts and currencies. Great work though!

Also, I'm getting a 422 error when trying to sign up. The error page doesn't say much, just:

¡Ouch!
El cambio que intentaste hacer fue rechazado.
A lo mejor trataste de cambiar algo para lo que no tienes acceso.
I hate to be "that guy," but what happened to the Guile-Emacs project? Guile performs way better than Elisp too, but (perhaps more importantly) raises the possibility of writing configuration and extensions in Lua and Scheme.
Tangentially related:

applying some commonly-recommended optimizations, you can shave Emacs init time to about 2 seconds, from whatever your previous init time was (7 in my case, but I also read about 60s -> 2s improvements).

Init time alone greatly affects how a given system is perceived.
The only reason they do it with a single sign instead of many is because the town is a speed trap funded city.

If there was not revenue generation, if the fines were required to go only in to the state or federal general budget, I believe the situation would shift towards one of the safe engineering solutions I outlined above instead of the revenue generating status quo you see today.
One idea I've read is to use those overhead wires for BEV busses, but only on certain segments. Most bus lines loop through a central area, so could charge along a section of a few blocks that feature the overhead wires.
I mean, the V bit, and the other contexts are just PTE permissions. It's literally the same root cause as meltdown, that page table faults occur particularly asynchronously on Intel hardware and speculation occurs past those faults.
I would never blame an Italian civil engineer. They are amongst the best of the world.

It's most likely a corrupt contractor paired with a corrupt politician to blame. They usually use bad or sloppy concrete, or not the planned amount of steel the engineer demanded.
How to Ask Questions the Smart Way – Eric Steven Raymond
I much prefer the definition of "racism" that has been in use since its inception, why change it?
It doesn't matter if your commute is as short as 2 miles - when one of those miles is a freeway. In a few urban areas, you can take side streets to avoid the freeway, but in much of the country, this is not an option.

For me, for example, avoiding the freeway adds 17 miles to my commute - turning it from a 10 mile one, into a 27 mile one, adding over 100 intersections to it (Compared to the 12 intersections that my regular commute has).

I'm going to have to pass on that.
Yeah, I bookmarked this to see if it would help with my code!
Random semi-tangential question: It seems that when companies/PR people/lawyers respond to lawsuits, they always use some version of this EXACT phrase:

"The allegations in the complaint are meritless, and ____ intends to vigorously defend against them."

Responses almost always use the word "meritless" (or "baseless") and almost always describe their forthcoming response to be "vigorous".

Is there a legal reason why these responses always use the same language? Or is this like an inside joke in legal circles?
Well, for one thing, that's not what the "you can't be racist against white people" folks say. Instead they say, "you can't be racist against white people".
"The main culprits for the change are software and the internet"

Stopped reading after that. This guy has a very loose understanding of what real people's lives are like. Throw Occam's razor out the window - the reason people own less stuff is not because they might have less money - no its because "society" has changed its "values" or some other air-headed notion ppl who live in airconditioned offices dream up.

The reason Americans own less stuff is because for 80%+ of the population wages haven't seen an increase in 3 decades and are up to their eyeballs in debt. "But GDP is so high!" - but nothing. What matters is the money that average people take home and for that they havent seen their income rise but they have seen the cost of education and healthcare go through the roof.
If you're the kind of person who thinks like this guy you're probably in the camp who thinks Trump got elected because "Far-Right Racists/Russian Hacking /The Patriarchy"

Sorry for the rant. I get an Inspector Dreyfus twitch when I read this sort of stuff by supposed 'smart' people
I went to school in 2000 - 2004 and students would say that if you got in a relationship with a professor or TA, they were required to transfer you to another class.

My math professor said, "Show me in the handbook where it says that." He then corrected me that, at least at our university, there were no explicit policies on teacher/student relationships. That professor said that every year, they got a big e-mail from the president reminding them of the sexual harassment policy.

If it's a company, yes they can have a policy that says "don't date across pay grades or you get fired." And some people fall in love and they take that risk and when the company finds out, they move them to different departments. .. Or they get fired; so they have to find new jobs. Hopefully it was worth it.

Private schools could probably do the same thing. In the public service space, it gets considerably harder to write these types of policies.
You would need every local, state, and federal entity to move to GAAP or IFRS instead of cash basis accounting at the same time. Otherwise some localities would purposefully not do so to claim that they're a tax haven good for attracting jobs. And such a move would probably require a massive correction in taxes or service levels or pensions to get back into shape, which would be a hard lift even for the most authoritarian of governments.

This is, in fact, how greenfield suburbs operate; they claim much lower tax rates because they don't really care about the infrastructure lifecycle, whereas cities are constantly maintaining and fixing things. Some of the first suburbs in America in Nassau County have such poor financial positions that county finances have been controlled by the state since 2000, and property taxes have hiked every year, with increases of up to 20% in a single year. https://en.wikipedia.org/wiki/Nassau_Interim_Finance_Authori...
What if this "Uber AI" can determined if you have cancer and what stage it is depending on the addresses you are dropped off and picked up at? What if Uber can peruse your browsing data and determined if you are a debt risk and/or not insured?

Perfect scenario for a dystopian "corporatocracy."
This is truly amazing and has so much baked in I find myself wanting to use it. However most apps my team and I work on require some form of persistence - uploads, log ins, API rate limits, etc. These scenarios don't fit well with the serverless world. It is technically possible to offset most of this to S3, a hosted NoSQL and perhaps even a service for dealing with a images/thumbnails. By that time your monthly bill is in the three digits, though. For a big web shop this is fine but your average freelancer with multiple smaller and finite-resource projects it's something to consider carefully.
At my last gig, we were using Firebase, Google's acquired-and-increasingly-integrated serverless solution. It was straightforward to have custom GCP instances that integrated with and extended our regular serverless workflows. In that scenario, it meant the compute instances tended to be extremely simple, as they were essentially just glorified event handlers.

Interestingly, as Firebase evolved during our use, nearly all of our external-instance use cases were obsoleted by more powerful native serverless support, esp. around functions.

All of which is the best of both worlds for serverless: an easy escape hatch to custom instances, and an ever-decreasing need for that escape hatch.
> (One last question: Could you clarify "I do my own taxes?" What is it that doing taxes yourself, presumably by pen and calculator, gains over downloading a product like TaxAct and saving the PDF of the result?)

The general principle I failed to articulate is that all other things being equal, I value Self Reliance over Interdependence.

There are varying levels of interdependence though, maybe I can take a stab at ranking them from least objectionable/risky to most.

1. Dependence on friends and family: largely acceptable in my view

2. Dependence on local community, groups, churches, etc.

3. Dependence on local government, public transport, libraries, etc.

4. Dependence on state/national government

5. Dependence on local businesses

6. Dependence on remote/global businesses

You might notice that the ranking is also ordered by how accountable (at least in theory) they are to you in terms of their actions, where businesses tend to be the least accountable. You can’t vote them out or alter their bad behavior, and their interests least align with yours.

EDIT

Also, I don’t see how paying a corporation for a Spotify subscription gives me any kind of “stake in society”.
More context:

In some simple benchmarks, it is about 3x faster than the bytecode interpreter.

I'm always skeptical of statements of these, because workloads vary so much.

JITs seem to do well for numerical benchmarks, e.g. summing a list of numbers or the mandelbrot fractal.

They seem to do worse with string-based workloads, because the bottleneck is in memory allocations, and I have yet to see a JIT that does anything about that (i.e. analyzing code to reduce allocations).

I imagine that ELisp is used mostly for string workloads and not numeric workloads. So I won't be surprised if the 3x number doesn't hold up. I'm interested in hearing more details and happy be to be corrected.