skysight-inc/HackerNews huggingface dataset:
LabGenius | London, UK | ONSITE | https://www.labgeni.us

LabGenius is developing an AI-driven evolution engine to discover novel, high-value proteins. We're a passionate team of synthetic biologists, data scientists and engineers based in Central London, and looking to revolutionise the way protein-based pharmaceuticals are developed. We primarily work in Python, running in GCP, with Vue.js powering our internal frontends.

To learn more about who we are, our engineering culture, and whether this is the right place for you, read our Key Values profile: https://www.keyvalues.com/labgenius

We're looking primarily for a Data Scientist right now, to help build out our AI-based protein design engine, but we're growing fast and we will soon be hiring for an Engineering Manager and Software Engineers (see the tech stack for more details on what we use).

- Data Scientist: https://labgenius.workable.com/j/1FD789C445

- All our open roles: https://labgenius.workable.com

Other roles/any questions, email me at oli 'at' labgeni 'dot' us
So, how long should we fast? I was thinking about doing 24h fasts every Friday instead of 3-day fasts every two months. Which one would be better from the article's point of view (as a preventive measure)?
> GIN is a recursive acronym for "GNU Identification Number," and...
This article is not about what could happen in the future.

This article is about what does happen now, and is stigmatized against being disclosed due of fear of personal reprecussions.

That was never the point of academia. These institutions exist with all their rules and regulations precisely because to discover and uncover, one must not be afraid of how it will affect oneself from keeping a roof over one's head.

Presently, this article is being severely misinterpreted.
Targets all deviding cells, with the faster-deviding cancer cells more affected.
Blockchain does actually turn me off from job postings, and a lot of the engineers i know feel the same way. Seems on the topic of their job posting & maybe will help them attract talent more eficiently in the future.

Feel like i'm getting the facebook treatment right now to be honest
It can't be the only reason. Saudy Arabia and Dubai are not exactly third-world countries.

Here's a world map showing population cancer rate: https://ourworldindata.org/grapher/share-of-population-with-...
Definitely cancer is positively correlated with wealth, but there is clearly another factor as well.
Cool idea but I can easily come up with areas reachable within X minutes but not within X+d minutes... Which would never happen unless you can't slow down! And not in a fancy way; just starting by car from Madrid, Berlin or Paris and looking into main roads.
Fidelity Introduces Zero Expense Ratio Index Funds
I've held this theory on my own after experiencing geometric shapes while hallucinating after smoking a lot of marijuana years back. I sat down closed my eyes and experienced an intense feeling of flying through what I can only explain as the starfield screen saver from Windows but with colored 2D shapes heavily dominated by hexagons of various sizes. During that experience I realized that I might be experiencing the inner workings of my brain in real time. I didn't give it much more thought but that ideas stuck in my mind for years. Recently I began fitness training with a trainer who believes in the stoned ape theory which reminded me of my own experience and I again read into it a bit. I'm not sold on the idea but the overall theory is solid in my book. Still to this day if I get really high I experience geometric hallucinations.
Sure, but no one wants illustrations of houses. They want photos.
> But I think your attitude is really about letting engineers shirk their responsibility as moral agents.

I absolutely disagree. That is why I specifically mentioned culpability for first order effects. If you build a gun for someone you know to be violent you have culpability for its use. What I disagree with is the broadening of this "liability" to include second order effects. That we are now supposed to predict chaotic systems and know in advance all perverse outcomes - and that we should have moral liability should we fail in this task.
200,000 routers in Brazil were secretly hijacked to mine cryptocurrency
Guide to Restricted Boltzmann Machines Using PyTorch
All kinds of film can fail (or be good) both at their genre, whatever it is, and at basic style and storytelling. For example, A Quiet Place maintains tension well, but it squanders its coherence and ruins a potentially great novel premise with pointless music and improbably contrived opportunities to let the characters speak.
Depends on your experience/expertise. I typically see vast ranges with more junior people charging $50/hr, intermediates at $80/hr, and seniors (people with decades of business experience) between $100-180/hr.

I sub out work now and then, I'll add an email address to my profile. I'd like to know your skill sets.
Yup. Lots of things are weird in Britain because it's old, this doesn't make those things a good idea to be copied. Though it also isn't a reason to dismiss them. Old isn't necessarily bad.

Britain's railway signalling is crazy because Britain's railways pre-date railway signalling. If you build a brand new railway you definitely shouldn't repeat mistakes from the 19th century.

Britain drives on the Left. Should you drive on the left too? Only if your neighbors do.

But on the other hand Britain decided to buy up all the doctors and hospitals and stuff to give everybody healthcare and that's worked out pretty well.
Can Cryptocurrency Revolutionize the Rituals of Money?
Amazon makes it so easy to buy stuff that I might buy some things that I would never have bought otherwise, but for the most part, money spent on Amazon is money that would have otherwise been spent in another retailer, who probably pays wages, rent and corporate tax as well.

If Amazon left the UK, people would still buy nearly as much as they do now.
Skipping lunches is also a good method of spending less time at work and more time outside enjoying life. I only take 15 minutes noon breaks now.
I've no idea about the fasting stuff. Just thought its important to make clear this particular study is all about doing stuff to cells or lumps of cells in dishes (again sorry if I missed more involved model system in the paper). Whether thats a good model for cancer in people and how fasting interacts with that I honestly have no idea.
Exactly! I'm looking at you, Delhi Airport! The f'n morons advertise "free wifi! free wifi!!" everywhere, but when you actually want to use it, they demand a phone number to send an SMS message. Are the people in charge there really that clueless??
> high carb, high fat, high protein

Is this an indirect way of saying people are eating high calories? Because most people use these terms in a relative manner. i.e. high carbs compared to fat and protein, or high fat and protein with fewer carbs.
Nerf guns are a rather narrow definition of fun.
That's too many decimal points if you were actually thinking critically.

Is your best argument really "well they could be dying of cholera and starve all the time so it's not that bad"?
I don't think ping is the problem... the problem is "line-of-sight"... Obviously, Earth rotates too fast, so you'd need to use a network of Earth-satellites getting the signal from the moon and transmitting it to the ground station. The other problem, maybe, is how to communicate... Can you have an antenna/laser on the rover itself, or would it need to transmit to a Moon-satellite first (e.g. to save weight on the lander)? How much energy do you need to communicate, can you do it continuously or do you need to "save" energy for a quick burst of radio signals every so often? Is there any other kind of interference (Moon regolith allegedly flies up to 100km above the surface)...

These are just simple issues that came to my mind. No idea how relevant they are, and if there are more relevant issues.
Fair enough - but then we could also discuss the restored kiva at Edge of the Cedars. It isn't a replica, it is a restoration from the original structure. Would that count?

I guess the point being simply that it seems more thought could have been put into the states where Native American structures have survived.
Why is it the worst thing you can do? It's funny - it's so easy to believe in conspiracy theories but then Shaolin monks and Steve Jobs die of cancer, and suddenly all of that goes out of the window. (Unless you make up another theory, but that's getting too convoluted)
Oh my, they removed 'cons' :(

hy 0.11.1 using CPython(default) 3.5.3 on Linux
=> (cons 1 '(2 3))
(1 2 3)

hy 0.15.0 using CPython(default) 2.7.13 on Linux
=> (cons 1 '(2 3))
Traceback (most recent call last):
File "/usr/local/lib/python2.7/dist-packages/hy/importer.py", line 199, in hy_eval
return eval(ast_compile(expr, "<eval>", "eval"), namespace)
File "<eval>", line 1, in <module>
NameError: name 'cons' is not defined
There is a high correlation between snacking and obesity.

The obesity crisis started in approx 1977. If you look at the the eating patterns from 1950, people ate less meals per day back then, an average of 3.

There's also a scientific explanation for it: when you snack, insulin goes up. By having 6 meals per day, like the average American now does, the insulin never goes down during the day. The body then develops insulin resistance, leptin resistance (satiety hormone) and it's all downhill from there.
I find engineers and entrepreneurs who shirk their responsibilities as moral agents tiresome.

If a thief comes and steals money under the mattress meant to pay for your kid's college tuition, and your kid is dropped because she can no longer pay, your kid's loss is a second order effect of the thief's theft, but I still hold the thief responsible*

* this is a hypothetical story; please don't save that kind of money under your mattress.
ICE Announces Bakkt, a Global Platform and Ecosystem for Digital Assets
I think that's an essential point, and though it's basic economics, it's often overlooked (and rarely made here). I'd take it a step further and say the grand project of building a better society (more freedom and economic opportunity) also is overlooked.

However, while automation helps in the aggregate, the world isn't lived or experienced in the aggregate but on the individual level. Put Jeff Bezos and 9 people living without shelter or money in a room, and in aggregate their average wealth is $15 billion per person; but that number tells you nothing about the individuals. When the factory closes due to technological advancement, sometimes those individuals can't get another job or one that pays nearly as much.

So we need to both encourage technological advances that increase productivity, but make sure it benefits individuals. I think the basic principle is that capital can move much more quickly than people - e.g., you can pull the money out of a factory in Kokkata or Indianapolis and invest bit in one in Hanoi much more quickly than the workers can move to Hanoi (probably impossible) or find another job anywhere. The answer may be much better unemployment insurance, retraining, and laws slowing economic changes enough that individuals can keep up, to a degree based on the economic impact: e.g., closing a big factory in a small town is higher impact than closing a startup in London.
You would have spent just as much on amazon if it paid it’s fair share of tax. I fail to see how their shareholders taking less profit would decrease your desire to consume.

Out of curiosity, what motivates you to defend a multinational company enriching itself at the direct expense of you? Of it being able to funnel billions of pounds away from your social services, your schools, your hospitals, your roads, your education system?
Our team of developers is 100% remote and we do a daily standup each morning that lasts anywhere from 15-30 minutes. Each person runs through anything of note from yesterday, our priorities for the coming day, any roadblocks, and anything we feel like discussing with the team.

Coming from a team that did nothing remotely close to a standup, I highly value our current system. It's not perfect, and I have no idea if it fits the Valley's definition of "standup", but it serves its purpose very well and keeps everyone on the same page. I can't tell you how many times a person from my team has reached out in the afternoon about a roadblock I mentioned during standup. Or how many times a team member wanted to help me out on a tough user story simply because I was open about discussing its difficulty.

This is just my opinion.
I went from Python to Go; Go is an amazingly simple and quick to learn language and ecosystem. Give it a try -- you'll probably start to feel proficient a lot faster than you'd think.
Interesting project.

I think "Lua inspired" instead of "based" would be more accurate.

I have been quite happy with luaj for "end-user" scripting on a clojure app we develop. While it requires to know a bit about lua internals it's quite easy to use. Also just using Lua (plus some bundled fns) buys us a lot of stuff for free (libs, docs, tutorials etc).

I guess an advantage of eden could be portability (cljs), but it's not something that matters to me.
I feel like the first sentence of the top response answered the question in a way that is quite relevant to this discussion:

"Many people use the terms somewhat interchangeably."

That is true. If we want to discuss the differences, it's important to know that sometimes people are using two terms to discuss the same thing.
It's items as I encounter them. This is a rough and overly-inclusive search, the first two items (at present) are relevant.

There are a few other examples I've submited to the mods via email.

https://plus.google.com/s/From%3A104092656004159577193%20"ha...
https://en.wikipedia.org/wiki/Sci-Hub https://news.ycombinator.com/item?id=17651419 and many more in recent HN posts...
I have the Bose QC35 and they are excellent.
> people going into 200k debt to become doctor's are mostly over paying

That's probably average combining undergrad and medical school. I go to one of the cheapest medical schools in the country, and it's > $240k in loans alone, let alone interest (plus the $130k from undergrad for me)
You could also say that this attitude holds us back. What if Smalltalk had only been accessible from vi back in the day, would Smalltalk have been as appreciated? I think not.
You might also want to look at Mark Mattson's work.

https://en.wikipedia.org/wiki/Mark_Mattson#Intermittent_Fast...
NYSE Owner Announces Bitcoin Venture with Starbucks, Microsoft
Wow I'd love to see this done and enforced in India!!
Likewise — and people often miss this angle — Comcast is a bit of an upstart itself in comparison to the two major incumbents, AT&T and Verizon. The two basically hold a duopoly on nationwide last-mile access, and they are using all their political power to prevent Comcast from becoming large enough to challenge them as a National last-mile telecom (they currently only offer service in something like 40% of the households in the US).

The prime case-in-point is the TimeWarner Cable merger that was scuttled — such a merger would have made Comcast effectively national, and a serious competitor to the old Bells. Meanwhile AT&T purchased DirecTV less than a year later (a deal worth more than the TWC acquisition in both dollars and customers) and the whole thing got rushed through quickly.

Do you think we would still have wired home Internet connections without Comcast? I know they’re a terrible company to be a customer of (what telecom isn’t though?) but when you look at the larger picture, they’re constantly stymied by the FCC from getting “too big” — meanwhile, their two biggest competitors are 2-4x larger on a revenue basis. Verizon and AT&T would drop their residential landline business in a heartbeat if Comcast weren’t around driving demand for it — the way Comcast’s tech architecture works makes it cheaper for them to serve the residential market than AT&T or Verizon will ever be able to do with wired connections.
Amazon now pays the lowest taxes ever
You have to be careful though; it's easy to get gallstones if you regularly fast and don't flush you're gallbladder with fatty foods afterwards.
works for most:

javascript:(function()%7Bvoid([].forEach.call(document.querySelectorAll('body *'),e=>/fixed|sticky/.test(getComputedStyle(e).position)&&e.parentNode.removeChild(e)))%3Bdocument.body.style.overflow%3D'auto'%3Bdocument.body.style.height%3D'auto'%7D)()
Doctorate of philosophy.

The Ph in PhD actually means something. It's not some kitschy decoration.
> The sparseness of connections between inhibitory neurons prevents inhibitory signals from traveling long distances, disrupting the stochastic Turing mechanism and the perception of funnels, cobwebs, spirals and so forth. The dominant patterns that spread through the network will be based on external stimuli — a very good thing for survival, since you want to be able to spot a snake and not be distracted by a pretty spiral shape.

I see spirals every time I meditate. I find it interesting the suggestion that meditation allows more random noise into my neurons.

It feels very similar to the dream state where the content usually has clear connections to my real life but is randomized just enough to produce some odd effects.

In the end, understanding dreams or hallucinations feels like interpreting art to me.
Nobody would be discussing the moral implications of scientific discoveries if it didn't ultimately lead to machines that cause effect in the real world. Science and Engineering are inextricably linked in this discussion.
It's more common than you'd think - I remember sitting in a talk in college by someone from Scaled Composites (they did SpaceShipOne etc) and they had said that they use inches everywhere.
The spittle-flecking above is not great, but calling people delusional because they disagree with your choices about ultimately meaningless technical crap is a profoundly shitty thing that you should feel some measure of shame for doing.

And I don't agree with you, either. While I like the idea of PowerShell (one of my GSoC submissions like a decade ago was to implement consistent coretools interfaces in C# so that another GSoCer's Mono-based shell could consume them) I personally find trying to actually write PowerShell--either in a script or on the command line--to be pretty disappointing. bash/zsh's syntax on the command line isn't great, but it's short and it's something with few enough permutations that writing it by hand is achievable; the hit-or-miss set, or lack thereof, of shorthand for commandlets and flags in PowerShell makes writing it difficult. Remembering the very long names, the strange syntax of stuff like a one-liner loop--it's pretty gnarly. Discoverable? Relatively speaking, yes. But it's not writable, to me. The experience is frontloaded for novices at the expense For a novice going `rm -rf` is surely complex; for an experienced programmer, writing `rm -Recurse -Force` is just gonna always be bad. (Ditto the odd co-opting of `rm` anyway; `grep` sure doesn't act like `grep` in PowerShell, the short aliases exist just to confuse.)

In a script, and as a programming language rather than a shell language...much like any other shell language, I write it literally only when forced to and if it weren't for Microsoft privileging operations inside of it I can't see a situation where I'd write it over Ruby. Its variable scoping is odd and requires more cognitive power than variable scoping should (we fixed that in JavaScript!) and the oddly bash-ish comparison operators have no real place, for me, in writing code. (They're not good in bash, either, but PowerShell doesn't get that excuse--it's supposed to be better and isn't.)

On top of that, there's a pretty good argument, and one I tend to agree with, that consistency is better than marginal improvements (and PowerShell is a marginal improvement over the combination of bash and Ruby or bash and Python). There is an alternate future where WSL has the ability to do everything, without blinking, that PowerShell can without having to get neck-deep in the .NET commandlet universe, and it's a universe where my tooling is drastically and radically simplified because I don't have to have completely separate execution paths just for that one client who actually cares about Windows.

I don't find any of that "delusional", and I think you should fix your tone and apologize to the person you said that to.
Prolonged water fasting of 14 to 40 days or dry fasting (no water, no food) for 4 to 10 days will rid your body of many "diseases" the modern medical world wants you to believe are either incurable or only treatable by whatever patented treatment they can sell you. Fasting is the enemy of Big Pharma and anyone else profiting monetarily in the modern medicine money machine, including doctors who will do all they can before they admit a simple fast fixes stuff they spent 10 years in school studying. Preventing fasting from entering the mainstream is criminal, but more and more people are slowly becoming aware and seeing the results.
I agree. It's a Euro-centric list, no queston.
Another wrong map. https://oalley.net/map/b4u

In 8h you can get to Salamanca(East of Barcelona) according to Google Maps, so like half of Spain should be marked.

It's also interesting that according to this, you can get to Monaco(6h 34m on Gmaps) , but no to Marseille (4h 54m on GMaps).
Python is regularly ranked to top 4 programming language for a reason, Go has a long way to catch up I think, if it ever happens.

I recently started using python as the primary language, the more I use, the more I like it.

Go's put everything in a static binary has its pros and cons.
Salt-infused graphene creates an infrared cloaking device
>> There are basically no small form factor 2400G systems and this have better graphics.

I've got a 2400G and have designed a very small form factor case specifically to house a Gigabyte AB350N Gaming WiFi ITX motherboard. It's so small the CPU fan and shroud will protrude through the top and will double as a case fan. I am just getting my new 3D printer setup and hope to print this thing this weekend. It's 195mm by 190mm by 60mm high, plus rubber feet to provide clearance for the vents which are on the bottom. It will be reasonably easy to relocate the CPU fan hole for different boards - it's position is 2 parameters in CAD. I'll try to post pics and CAD files someplace when the design is fully printed and finalized. Or perhaps make it available on Shapeways? There is opportunity to shrink it more in the future, but I went for 30mm radius curves on the front and haven't shaved every mm off the height.

Running Fedora Rawhide, there are some issues still but it's amazing when it boots properly. Plays Video on my 4K TV while barely making a sound or heating up.
Jobs was a fruitarian in the 80s or earlier, back when he named his company "Apple". AFAIK he was neither fasting or being a fruitarian to fight his cancer, but overall he was a finicky eater all his life, a (sometimes lax) vegetarian with bouts that resembled a true eating disorder.
They're referring to this lawsuit: https://www.nytimes.com/2018/07/29/us/harvard-admissions-asi...
Be your own bank! (tm)
I love Go and use it for allllmost everything, but I think bash is still better for something like this. The ease with which it can run programs and capture output is the killer feature.

I'd love to see some future bash like language that's strongly typed, has a consistent and simple syntax, but retains these advantages.
then there's reddit and its giant full page ad for the app before finally redirecting me to the content once i find the tiny link to continue instead of opening the app store...

yes reddit and fb and gmail and the like are intentionally crippled when viewed on mobile. why? maybe because the data an app can suck up off your phone is much more valuable. no pesky same-origin policies!

i digress :(